Best TWAS P=1.92e-26 · Best GWAS P=2.86e-25 conditioned to 0.00184
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Putamen basal ganglia | TXNDC15 | 0.39 | -0.01 | enet | 22 | 0.06 | 1.6e-02 | 0.11 | 5.3 | 1.3e-07 | 0.02 | 0.03 | 0.39 | TRUE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | GDF9 | 0.27 | 0.10 | lasso | 5 | 0.15 | 1.1e-05 | 2.68 | -5.9 | 3.7e-09 | 0.04 | 0.19 | 0.55 | FALSE |
| 3 | GTEx | Muscle Skeletal | HSPA4 | 0.13 | 0.09 | enet | 22 | 0.09 | 1.5e-09 | 10.16 | 9.7 | 4.1e-22 | -0.03 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Nerve Tibial | HSPA4 | 0.15 | 0.07 | lasso | 3 | 0.05 | 1.0e-04 | 10.21 | 10.6 | 1.9e-26 | -0.05 | 0.01 | 0.99 | TRUE |
| 5 | GTEx | Testis | HSPA4 | 0.13 | 0.13 | lasso | 2 | 0.12 | 9.1e-06 | 10.19 | 10.2 | 2.1e-24 | -0.04 | 0.01 | 0.99 | FALSE |
| 6 | METSIM | Adipose | SMAD5 | 0.06 | 0.08 | bslmm | 466 | 0.08 | 1.4e-11 | -5.82 | -6.5 | 9.6e-11 | 0.54 | 1.00 | 0.00 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | TCF7 | 0.06 | 0.00 | bslmm | 492 | 0.01 | 6.5e-03 | -2.85 | -5.4 | 6.5e-08 | -0.05 | 0.13 | 0.49 | FALSE |
| 8 | YFS | Blood | HSPA4 | 0.17 | 0.02 | blup | 433 | 0.09 | 2.8e-27 | 9.80 | -6.4 | 1.9e-10 | 0.03 | 0.04 | 0.96 | FALSE |
| 9 | YFS | Blood | SKP1 | 0.19 | 0.18 | lasso | 5 | 0.20 | 1.8e-63 | 4.87 | -6.0 | 1.5e-09 | -0.08 | 0.99 | 0.01 | FALSE |
| 10 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SMAD5OS | 0.04 | 0.01 | enet | 5 | 0.02 | 8.3e-03 | -6.23 | -8.3 | 1.4e-16 | 0.82 | 0.01 | 0.73 | TRUE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HSPA4 | 0.03 | 0.02 | blup | 50 | 0.02 | 5.8e-05 | 9.80 | -9.2 | 5.9e-20 | 0.09 | 0.03 | 0.96 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SMAD5 | 0.01 | 0.00 | blup | 60 | 0.01 | 6.8e-03 | -5.91 | -6.0 | 2.4e-09 | 0.46 | 0.09 | 0.03 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZCCHC10 | 0.03 | 0.02 | blup | 30 | 0.02 | 1.3e-05 | 9.80 | -10.4 | 2.4e-25 | 0.07 | 0.02 | 0.97 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | H2AFY | 0.09 | 0.02 | enet | 7 | 0.05 | 1.4e-06 | -6.50 | 5.7 | 1.1e-08 | -0.06 | 0.01 | 0.98 | TRUE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LEAP2 | 0.08 | 0.08 | enet | 4 | 0.09 | 3.7e-10 | 6.97 | 8.7 | 5.3e-18 | -0.01 | 0.01 | 0.99 | TRUE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SHROOM1 | 0.08 | 0.09 | lasso | 2 | 0.08 | 1.0e-09 | 8.36 | 8.4 | 5.8e-17 | 0.00 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SHROOM1 | 0.05 | 0.01 | blup | 38 | 0.02 | 2.5e-02 | 2.90 | 5.4 | 7.0e-08 | -0.02 | 0.01 | 0.71 | FALSE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HSPA4 | 0.09 | 0.01 | blup | 50 | 0.05 | 4.1e-06 | 1.52 | 6.9 | 4.3e-12 | -0.01 | 0.03 | 0.64 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Adenocarcinoma | UQCRQ | 0.02 | 0.01 | blup | 33 | 0.01 | 3.2e-02 | 8.61 | -7.8 | 8.2e-15 | 0.03 | 0.00 | 0.88 | FALSE |
| 20 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | GDF9 | 0.08 | 0.03 | enet | 5 | 0.05 | 3.5e-03 | 2.90 | -5.7 | 1.2e-08 | 0.03 | 0.03 | 0.28 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SMAD5OS | 0.02 | 0.03 | enet | 3 | 0.02 | 1.4e-03 | -5.68 | -5.9 | 4.1e-09 | 0.58 | 0.08 | 0.08 | TRUE |
| 22 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | LEAP2 | 0.24 | 0.06 | enet | 9 | 0.07 | 2.1e-03 | 8.40 | 7.4 | 1.1e-13 | 0.00 | 0.01 | 0.72 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC389332 | 0.03 | 0.03 | blup | 38 | 0.02 | 6.5e-03 | -5.89 | 5.5 | 3.1e-08 | -0.45 | 0.03 | 0.96 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | PPP2CA | 0.03 | 0.01 | blup | 33 | 0.02 | 5.4e-03 | 6.39 | 6.4 | 1.4e-10 | 0.04 | 0.01 | 0.78 | TRUE |