Hub : Genes

H2AFY

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Ovary	0.3780	0.1310	4.6e-03	0.028	NA	0.036	NA	0.130	0.0700	NA	4.6e-02	NA	4.5e-04
2	NTR	Blood	0.0348	0.0114	7.0e-05	0.002	0.009	0.004	0.007	0.002	0.0500	3.5e-04	1.8e-02	0.0015	6.0e-02
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0933	0.0362	4.5e-05	0.019	0.051	0.053	NA	0.050	0.0027	1.8e-06	1.4e-06	NA	2.6e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.8	1.2	2.6	-0.5	1.6	-0.9
Bipolar Disorder or Schizophrenia	1.1	2.6	5.0	-1.2	2.2	-1.1
Depressed Affect (Nagel 2018)	0.1	0.1	0.4	0.0	-0.6	-0.2
Depression (Nagel 2018)	0.2	0.3	0.9	-0.4	0.1	-0.9
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.5	1.2	-1.0	0.9
Neuroticism (Nagel 2018)	0.1	0.2	0.6	-0.3	0.8	0.0
Schizophrenia (2018)	0.7	1.5	2.4	-1.2	1.6	-0.7
Schizophrenia vs Biploar Disorder	2.3	3.1	6.0	2.4	-1.7	0.6
Worry (Nagel 2018)	0.3	0.5	1.5	-0.2	0.2	1.2
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	-0.3	-0.4	-0.2
Alzheimer’s Disease (in father)	1.7	1.9	3.3	-1.8	-1.5	0.1
Alzheimer’s Disease (including proxy)	1.2	1.7	4.5	-0.7	-2.1	0.1
Crohns Disease (2017)	0.8	1.8	5.2	0.3	-2.3	0.1
Irritable Bowel Disease (IBD)	1.4	3.3	9.7	0.2	-3.1	-0.5
Ulcerative Colitis (UC)	1.3	2.4	7.1	0.1	-2.7	-0.5
Major Depression (MDD)	0.0	0.0	0.1	0.3	0.0	-0.2
Reaction Time	0.3	0.6	1.2	0.6	-1.1	0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.2	0.8	-1.1	-0.2
Breast Cancer	0.3	0.7	0.9	-1.0	0.8	-0.6
Ovarian Cancer	0.8	1.0	2.0	-1.4	-0.7	0.8
Prostate Cancer	0.8	1.1	1.5	-1.2	-1.0	1.0
Age at First Birth	0.4	0.6	0.9	-0.9	-0.8	0.6
Bipolar Disorder (2011)	4.4	4.3	9.9	-1.6	3.1	-0.7
Body Mass Index (BMI) (2010)	1.2	1.7	3.2	0.8	-1.8	1.1
Coronary Artery Disease (CAD)	0.3	0.3	0.4	0.5	0.5	-0.7
Crohns Disease (2012)	0.1	0.2	0.2	0.5	-0.4	0.3
Mean Putamen Volume	1.6	1.8	2.6	-1.4	-1.6	-0.9
Fasting Glucose	1.3	1.5	2.1	1.4	0.6	1.5
HbA1C	1.2	1.4	3.1	1.8	-0.1	1.0
HDL Cholesterol	0.2	0.3	0.6	-0.4	0.4	-0.8
LDL Cholesterol	0.4	0.6	1.0	1.0	-0.5	0.6
Lupus	0.2	0.2	0.5	-0.4	0.7	0.3
Neuroticism (2016)	0.1	0.2	0.5	-0.3	0.3	-0.7
Primary Biliary Cirrhosis	0.5	0.7	1.2	0.9	1.1	-0.4
Rheumatoid Arthritis	0.2	0.2	0.4	-0.1	0.5	0.7
Schizophrenia (2014)	0.8	1.8	2.2	-1.2	1.5	-1.3
Triglycerides	0.3	0.4	1.3	0.0	-0.2	1.1
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.2	0.5	1.2	-1.5
Ulcerative Colitis	1.2	1.8	4.9	-0.5	-2.2	-0.6
Blood Eosinophil Count	0.5	4.1	7.3	-2.7	-1.7	1.4
Blood Platelet Count	0.0	0.1	0.1	-0.2	0.3	0.2
Blood Red Count	0.1	0.7	1.1	-0.1	1.1	-1.0
Blood White Count	0.3	2.1	5.9	-0.5	2.4	0.2
Heel T-Score	1.6	12.4	32.7	-1.7	-1.2	5.7
BMI	0.1	0.9	1.4	1.0	-0.5	-1.2
Height	0.1	1.0	2.4	-0.1	1.5	-0.7
Waist Hip Ratio (WHR)	0.4	1.7	3.9	2.0	-0.7	-0.9
Systolic Blood Pressure	0.1	0.6	1.0	-1.0	-0.5	0.7
Smoking Status	0.9	2.1	4.7	2.2	1.2	0.2
Allergy or Eczema	0.2	0.5	0.7	-0.8	0.3	-0.8
Cardiovascular Disease	0.2	0.8	1.8	-1.3	-0.8	0.1
Hypothyroidism (self reported)	0.3	0.6	1.0	-0.9	0.2	1.0
Respiratory disease	0.5	1.2	2.0	1.1	0.5	-1.4
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.8	0.5	-0.6	0.9
Lung FEV1/FVC ratio	0.4	2.0	3.5	1.9	-1.2	-0.9
Lung FVC	0.2	0.9	1.7	-1.0	-0.3	1.3
Neuroticism	0.0	0.0	0.0	-0.1	0.1	0.1
Chronotype (morning person)	0.6	1.3	2.3	-0.2	-1.2	1.5
Hair Pigment	0.0	0.8	1.4	0.7	-1.2	-0.6
Tanning	0.2	2.3	4.6	-2.1	0.2	1.5
Hand grip strength (left)	0.2	0.6	0.8	-0.8	-0.9	0.7
Number of treatments/medications taken	0.5	0.9	2.3	0.0	0.7	1.5
Average weekly spirits intake	0.5	0.7	1.0	0.6	0.8	-1.0
Sensitivity / hurt feelings	0.4	0.7	1.6	-0.7	1.2	-0.1
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.0	0.1	0.7	-1.4
Hearing difficulty/problems: Yes	0.2	0.4	0.9	-0.4	0.1	-1.0
Relative age of first facial hair	0.1	0.3	0.6	-0.3	-0.4	0.7
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	2.3	1.0	-0.3	-1.5
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.5	0.1	0.7	-0.7
Ever had hysterectomy (womb removed)	1.3	1.5	3.3	-1.0	0.5	-1.8
Systolic blood pressure, automated reading	0.1	0.2	0.4	0.3	-0.6	-0.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	-0.2	0.1	0.7
Angina	0.6	0.8	1.9	-1.4	0.5	0.3
Medication for hormone replacement therapy	2.0	2.3	3.1	1.8	0.8	-1.8
Vitamin and mineral supplements	0.4	0.6	1.2	1.1	0.7	-0.1
Supplements: Zinc	0.0	0.0	0.0	0.0	-0.2	-0.0
Medication: Co-codamol	0.4	0.5	0.9	0.5	-1.0	0.6
Medication: Metformin	0.1	0.1	0.2	0.4	0.1	0.1
Diabetes (father)	0.2	0.2	0.7	0.9	0.0	-0.0
Diabetes (mother)	0.7	0.9	1.5	-1.0	-1.2	0.0
Severe depression (siblings)	0.1	0.1	0.2	-0.4	0.1	0.1
Pack years adult smoking proportion	0.2	0.3	0.7	0.0	-0.9	0.3
Impedance of leg (right)	0.3	1.5	3.2	-1.8	-0.0	1.1
Leg fat-free mass (left)	0.2	1.2	1.4	1.1	1.2	-0.9
Trunk fat percentage	0.0	0.2	0.3	-0.5	0.3	-0.4
Hand grip strength (right)	0.1	0.2	0.3	-0.5	-0.5	-0.4
Townsend deprivation index at recruitment	1.8	2.5	5.8	-0.9	2.4	-0.9
Current tobacco smoking	0.2	0.4	1.1	1.1	-0.0	0.2
Average weekly fortified wine intake	0.1	0.2	0.3	0.6	-0.2	0.3
Maternal smoking around birth	0.5	0.7	2.0	-0.0	-1.4	0.1
Fed-up feelings	0.2	0.4	0.6	-0.7	-0.1	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	1.9	0.5	1.3	-1.4
Relative age voice broke	0.6	0.9	2.1	-0.6	-1.5	0.4
Taking other prescription medications	0.2	0.4	0.8	0.4	-0.4	0.9
Age when periods started (menarche)	0.1	0.3	0.6	-0.8	0.2	0.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.7	0.5	0.1	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.3	0.2	1.1	1.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.5	-0.0	0.7	1.2
Qualifications: CSEs or equivalent	2.5	3.3	6.2	-1.9	-0.3	2.5
Serious illness, injury or assault to yourself	0.6	0.7	1.5	-0.2	0.8	1.2
High blood pressure	0.0	0.1	0.1	-0.1	-0.4	0.3
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.9	-0.9	-0.4	-0.7
Multivitamins +/- minerals	0.4	0.5	1.4	-1.2	-0.3	-0.1
Stomach or abdominal pain in last month	0.3	0.4	0.6	-0.2	-0.7	-0.8
Supplements: Glucosamine	1.1	1.4	2.9	0.5	1.7	-1.0
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.3	-1.5	0.5	-1.2
Medication: Atenolol	0.9	1.1	2.1	1.5	0.4	1.0
Medication: Levothyroxine sodium	0.2	0.4	0.7	-0.7	0.9	0.2
Sitting height	0.2	1.2	2.8	-0.9	1.7	-0.3
Chronic bronchitis/emphysema (father)	1.2	1.4	3.5	-0.8	-1.9	0.2
High blood pressure (mother)	2.8	4.0	7.8	-0.1	-2.8	2.0
Body mass index (BMI)	0.0	0.1	0.2	0.1	0.5	-0.1
Impedance of leg (left)	0.2	1.0	2.0	-1.4	0.6	0.8
Leg predicted mass (left)	0.2	1.1	1.5	1.0	1.2	-0.9
Trunk fat mass	0.1	0.3	0.5	-0.3	0.7	-0.5
Waist circumference	0.3	0.9	1.9	0.6	1.4	-0.7
Number of incorrect matches in round	1.0	1.6	3.1	-1.2	0.6	-1.7
Past tobacco smoking	0.6	1.1	1.9	-1.4	-1.0	0.6
Alcohol usually taken with meals	0.2	0.3	0.8	0.3	0.0	-0.9
Nervous feelings	0.2	0.4	0.9	0.9	0.6	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.2	-0.1	1.8	0.4
Hearing difficulty/problems with background noise	0.1	0.1	0.3	-0.5	-0.1	-0.4
Hair/balding pattern: Pattern 2	3.0	3.8	9.1	-1.5	3.0	-0.3
Had menopause	0.2	0.3	0.6	0.4	-0.3	0.7
Had other major operations	1.5	1.9	3.5	-0.3	1.4	-1.9
Forced vital capacity (FVC)	0.4	1.6	4.8	-0.3	2.2	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.3	-0.6	0.3	1.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.3	-0.4	-0.6	-0.4
Qualifications: None of the above	1.1	2.3	3.9	-0.3	2.0	-1.7
Financial difficulties in last 2 years	0.2	0.3	0.6	0.6	-0.8	0.3
Mouth/teeth dental problems	1.0	1.5	3.6	-0.7	-1.9	0.6
Heart attack	0.4	0.5	0.9	-0.6	1.0	-0.4
Allergy	0.1	0.3	0.4	0.6	0.2	0.6
Pain all over the body in last month	0.6	0.6	0.8	0.9	0.9	0.6
Diabetes (self-reported)	0.6	0.9	2.0	0.8	-0.5	1.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.2	-0.0	-0.7	1.1
Medication: Ramipril	0.4	0.5	0.8	-0.9	0.9	-0.2
Medication: Simvastatin	1.7	2.5	6.0	-0.1	-1.2	2.5
Fluid intelligence score	0.3	0.6	0.9	0.9	-0.2	-1.0
Illnesses of siblings	0.9	1.3	3.1	0.9	1.8	0.3
Neuroticism score	0.0	0.1	0.1	-0.3	0.3	0.3
Weight	0.1	0.6	1.3	0.3	1.1	-0.6
Impedance of arm (right)	0.2	0.9	1.2	-0.9	0.8	-1.1
Arm fat percentage (right)	0.1	0.2	0.4	-0.4	0.7	-0.2
Trunk fat-free mass	0.2	0.9	1.7	0.7	1.3	-0.7
Hip circumference	0.4	1.8	4.7	-0.8	2.2	-0.0
Time employed in main current job	1.4	1.7	2.8	-0.9	-1.7	1.2
Alcohol intake versus 10 years previously	1.0	1.5	2.4	1.5	1.4	-0.2
Father’s age at death	0.6	0.8	2.3	0.1	-1.5	0.2
Worrier / anxious feelings	0.9	1.6	2.5	-1.6	-0.8	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.5	-0.6	1.6	-0.7
Falls in the last year	0.4	0.5	0.9	-0.9	0.5	-0.6
Hair/balding pattern: Pattern 3	0.4	0.7	0.9	0.9	-0.8	0.7
Number of live births	1.3	1.9	2.5	-1.3	1.2	1.6
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	4.3	-0.1	2.1	-0.2
Pulse rate	0.4	0.7	1.8	1.4	0.2	-0.5
Happiness	0.5	0.6	1.4	1.2	0.5	0.1
Noisy workplace	3.9	4.8	10.7	1.9	3.3	-0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.3	-0.3	-0.7	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.7	1.4	0.7	1.2	-0.6
Mouth/teeth dental problems: Dentures	1.0	1.7	4.0	0.4	2.0	-1.0
Asthma	0.2	0.5	1.0	1.0	-0.2	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.3	0.8	1.5	0.3
Medication: Cholesterol lowering	3.0	4.6	10.0	-1.8	-0.9	3.2
Depression (self-reported)	0.6	0.7	1.4	-0.3	-1.2	0.8
Medication: Lansoprazole	0.4	0.5	0.7	0.8	-0.2	-0.8
Prospective memory result	0.1	0.1	0.1	0.3	-0.0	0.4
Lung cancer (father)	0.7	0.8	1.2	-0.8	-0.6	-1.1
Illnesses of mother	2.3	2.9	8.4	0.2	2.9	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.7	-0.5	1.6	0.5
Pulse wave Arterial Stiffness index	0.6	0.7	1.2	-0.9	-0.3	1.1
Impedance of arm (left)	0.2	0.8	2.1	-0.5	-0.2	-1.4
Arm fat mass (right)	0.1	0.5	1.4	0.1	1.2	-0.4
Trunk predicted mass	0.2	0.9	1.6	0.8	1.2	-0.7
Standing height	0.2	2.0	4.2	0.3	2.1	-1.3
Length of working week for main job	0.2	0.2	0.6	0.3	-0.8	0.0
Exposure to tobacco smoke at home	0.4	0.5	1.1	-1.1	-0.2	0.4
Breastfed as a baby	0.7	0.9	2.2	-0.7	0.0	1.5
Tense / ‘highly strung’	0.3	0.4	0.9	0.2	1.0	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.2	0.8	-0.4
Hair/balding pattern: Pattern 4	0.6	1.5	4.2	2.1	0.5	0.3
Birth weight of first child	0.6	1.1	2.8	-1.7	0.2	0.7
Peak expiratory flow (PEF)	0.2	0.5	1.4	-1.2	-0.4	0.3
Pulse wave reflection index	1.8	2.3	5.5	-2.3	1.1	0.4
Ever highly irritable/argumentative for 2 days	1.1	1.4	3.0	1.7	0.9	0.5
Loud music exposure frequency	0.7	0.8	1.5	-1.2	-0.4	-0.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	3.1	0.6	-0.3	1.8
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	0.8	0.0	-0.4
Blood clot in the leg (DVT)	1.7	2.2	3.7	-1.9	-1.4	1.0
Medication: Paracetamol	0.4	0.6	1.6	0.1	1.3	0.4
Headache pain in last month	3.0	5.1	6.7	-2.4	2.6	-1.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	0.2	-0.2	-1.0
Glaucoma (self-reported)	2.6	3.1	7.7	-0.9	0.9	-2.8
Gout (self-reported)	2.4	3.2	8.5	0.4	2.9	-1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	-0.6	0.1	0.9
Medication: Amlodipine	0.8	1.1	2.3	-1.5	-0.3	1.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.2	0.2	1.1	-0.3
Birth weight	0.8	1.8	3.6	-1.9	-0.4	1.3
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.3	1.5	-1.0	-0.7
High blood pressure (siblings)	0.5	0.7	1.2	-0.9	-1.1	-0.2
Forced vital capacity (FVC), Best measure	0.4	1.3	2.1	-0.8	1.4	1.1
Body fat percentage	0.0	0.2	0.4	-0.6	0.3	0.0
Leg fat percentage (right)	0.2	0.8	1.6	-0.9	-0.2	1.3
Arm fat-free mass (right)	0.2	1.0	1.6	1.2	1.3	-0.1
Exposure to tobacco smoke outside home	0.2	0.3	0.8	-0.3	0.9	-0.3
Comparative body size at age 10	0.9	2.5	5.9	-2.4	1.0	-0.7
Number of full brothers	0.6	0.7	1.1	-0.9	-0.5	1.0
Worry too long after embarrassment	0.6	1.0	1.5	-1.2	0.0	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.2	0.7	0.7	-1.5
Wheeze or whistling in the chest in last year	0.6	1.0	3.0	0.1	0.4	-1.7
Number of children fathered	2.0	2.2	5.2	-1.1	-2.3	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	-0.2	-0.4	-0.7
Age at first live birth	0.9	1.6	2.2	1.0	-1.2	1.5
Pulse wave peak to peak time	0.6	0.6	1.0	1.0	0.2	-1.0
Health satisfaction	0.8	1.0	1.9	0.5	0.9	1.4
Shortness of breath walking on level ground	1.3	1.6	2.7	1.0	1.6	-1.0
Qualifications: College or University degree	0.6	2.0	3.1	1.8	-1.2	1.2
Eye problems/disorders: None of the above	1.3	1.5	4.0	0.5	-0.4	2.0
Mouth/teeth dental problems: Loose teeth	0.9	1.0	2.4	-1.5	0.8	0.0
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.7	0.3	0.4
Medication for pain relief, constipation, heartburn	0.5	0.8	2.5	0.0	-1.6	0.1
Neck or shoulder pain in last month	2.8	4.0	9.4	-0.7	3.1	-1.5
Medication: Blood pressure	0.1	0.1	0.2	-0.5	0.3	-0.3
Angina (self-reported)	0.6	0.8	2.0	-1.4	0.3	0.4
Migraine (self-reported)	2.3	2.8	4.4	-2.0	-0.1	2.1
Medication: Ibuprofen	0.9	1.1	2.6	0.7	1.6	0.4
Medication: Allopurinol	0.6	0.8	1.9	0.5	1.4	-0.6
Medication: Omeprazole	0.5	0.6	1.1	-0.5	1.1	-0.5
Medication: Seretide 50 evohaler	1.1	1.3	3.7	-0.1	-1.9	-0.1
Mean time to correctly identify matches	0.6	1.1	2.9	0.4	-1.7	0.6
Heart disease (mother)	1.1	1.4	2.6	-1.6	-0.7	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	-0.2	0.8	0.0
Whole body fat mass	0.0	0.2	0.4	-0.1	0.7	-0.3
Leg fat mass (right)	0.0	0.1	0.2	-0.3	0.3	0.4
Arm predicted mass (right)	0.2	0.8	1.5	1.2	1.0	-0.0
Pulse rate, automated reading	0.2	0.6	1.0	0.8	1.0	-0.4
Alcohol intake frequency.	0.2	0.6	1.1	-1.0	0.2	0.8
Comparative height size at age 10	0.6	3.1	4.0	1.8	2.0	-1.4
Number of full sisters	0.3	0.3	0.4	-0.6	0.5	0.6
Suffer from ‘nerves’	0.9	1.4	3.6	0.6	0.4	1.9
Overall health rating	1.5	3.1	7.4	1.4	2.7	-0.3
Chest pain or discomfort	1.2	1.7	2.6	-0.2	1.6	-1.6
Had major operations	0.2	0.2	0.5	0.7	0.3	-0.3
Age at last live birth	0.8	1.1	1.9	0.5	-1.1	1.4
Family relationship satisfaction	0.9	1.1	1.4	1.2	0.9	-1.1
Leg pain on walking	0.3	0.3	0.8	0.2	0.5	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.6	-1.6	-0.2	-0.1
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.5	-0.5	-1.2	1.9
Illness, injury, bereavement, stress in last 2 years	2.1	2.5	3.7	-1.9	0.5	-1.9
Medication: Aspirin	1.6	2.1	5.9	-2.4	0.6	0.0
Supplements: Vitamin C	1.1	1.3	2.0	-0.9	1.4	-0.9
Knee pain experienced in last month	1.2	1.9	3.5	0.8	1.9	-1.3
Hypertension (Self-reported)	0.0	0.1	0.2	-0.1	-0.4	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	4.3	-1.1	-0.1	-2.1
Illnesses of father: Heart disease	0.4	0.5	1.3	1.1	0.2	-0.5
Illnesses of siblings: Diabetes	2.0	2.4	6.7	0.1	-2.6	0.7
Smoking status: Previous	0.2	0.3	0.9	0.2	0.9	0.0
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	3.4	-0.1	1.8	-1.8
Whole body fat-free mass	0.2	1.1	1.8	1.0	1.3	-0.7
Leg fat-free mass (right)	0.3	1.8	2.1	1.3	1.4	-1.2
Arm fat percentage (left)	0.0	0.1	0.2	-0.3	0.4	-0.4
Average weekly red wine intake	0.8	1.1	1.6	1.3	1.2	-0.7
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	-0.2	0.5	0.9
Mood swings	0.4	0.7	1.3	-1.2	0.8	-0.4
Loneliness, isolation	1.4	1.9	5.4	0.5	0.1	-2.3
Long-standing illness, disability or infirmity	1.2	1.8	3.1	1.3	1.8	-0.8
Ever had bowel cancer screening	1.3	1.5	3.7	-0.3	-1.9	0.9
Diabetes diagnosed by doctor	1.0	1.6	3.5	0.9	-0.7	1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.8	0.7	0.1	1.7
Friendships satisfaction	1.3	1.7	3.3	1.8	-0.1	-1.3
Qualifications: nursing, teaching	0.6	1.0	2.7	-0.0	-1.6	-0.5
Commuting to job workplace: Walk	1.4	1.5	2.8	-0.0	1.7	-1.4
Eye problems/disorders: Cataract	0.7	0.8	1.5	-0.1	1.2	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.7	0.7	1.3	-0.6
Medication for cholesterol	0.0	0.0	0.1	-0.2	-0.0	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.0	1.0	-0.2	0.7
Back pain experienced in last month	3.0	4.4	6.3	1.6	2.5	-2.1
Mineral and other dietary supplements	0.8	1.0	1.5	-0.2	-1.2	1.2
Breast cancer (self-reported)	0.3	0.3	0.7	-0.5	0.2	-0.8
Asthma (self-reported)	0.4	0.8	1.7	1.3	-0.4	-0.8
Osteoporosis (self-reported)	1.5	1.9	2.6	1.6	-1.4	1.1
Osteoarthritis (self-reported)	1.0	1.3	2.0	1.4	1.3	0.3
Medication: Aspirin	1.6	2.1	5.9	-2.4	0.7	0.0
Medication: Gliclazide	1.9	2.2	6.5	-0.1	-0.3	2.5
Illnesses of father: None of the above (group 1)	3.2	3.9	6.3	-2.5	-1.4	1.8
Smoking status: Current	0.4	0.6	1.8	1.3	0.3	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	5.3	-1.8	2.3	0.6
Whole body water mass	0.2	1.2	2.0	1.0	1.4	-0.7
Leg predicted mass (right)	0.4	2.0	2.5	1.4	1.6	-1.2
Arm fat mass (left)	0.1	0.4	1.0	0.0	1.0	-0.6
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	-0.3	-0.2	0.4
Average weekly champagne plus white wine intake	0.7	0.9	2.0	-0.7	-1.4	0.5
Miserableness	0.0	0.0	0.1	0.1	0.3	0.0
Guilty feelings	0.4	0.6	1.0	0.1	-1.0	0.9
Wears glasses or contact lenses	0.5	0.6	1.5	-1.2	0.4	-0.4
Ever taken oral contraceptive pill	0.6	0.7	1.9	-0.4	-1.4	-0.0
Hearing aid user	1.0	1.1	3.0	0.6	0.3	-1.7
Mother’s age at death	1.0	1.3	1.7	1.2	-1.3	0.9
Financial situation satisfaction	0.5	0.7	1.2	0.8	1.1	-0.4
Tinnitus: Yes, now most or all of the time	1.6	1.9	3.6	-0.8	-1.9	1.2
Commuting to job workplace: Public transport	1.5	1.8	3.5	1.1	0.8	-1.9
Eye problems/disorders: Glaucoma	0.9	1.1	2.2	-0.9	0.3	-1.5
Medication: Blood pressure	0.1	0.2	0.2	-0.3	-0.5	0.4
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.4	0.9	1.2	-0.8
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.3	0.0	1.1	-0.9
High cholesterol (Self-reported)	0.6	1.1	2.2	-0.9	-1.5	0.5
Medication: Bendroflumethiazide	0.3	0.4	1.1	-1.1	-0.2	-0.3
Medication: Paracetamol	0.3	0.5	0.6	0.8	0.6	0.8
Medication: Lisinopril	1.1	1.4	2.7	-0.0	1.2	-1.7
Medication: Atorvastatin	2.7	3.3	6.2	-1.9	0.3	2.5
Illnesses of father: High blood pressure	3.5	4.4	7.9	2.8	1.8	-1.5
Alcohol drinker status: Never	0.5	0.6	1.1	-0.9	0.2	1.0
Ever smoked	1.5	2.6	6.2	2.5	0.4	-1.2
Basal metabolic rate	0.2	1.0	1.9	0.9	1.4	-0.6
Leg fat percentage (left)	0.2	0.6	1.3	-0.7	0.1	1.1
Arm fat-free mass (left)	0.2	0.9	1.8	1.0	1.3	-0.2
Number of operations (self-reported)	2.6	3.8	4.2	2.1	2.0	-1.9
Average weekly beer plus cider intake	0.2	0.3	0.8	-0.5	0.1	-0.9
Irritability	1.1	1.9	4.2	-0.8	2.1	-0.9
Risk taking	1.0	1.4	3.0	0.7	-1.7	-0.8
Ever had prostate specific antigen (PSA) test	1.4	1.6	2.2	1.0	-1.5	1.3
Fractured/broken bones in last 5 years	0.9	1.2	2.0	-1.1	-1.4	0.6
Age started oral contraceptive pill	0.9	1.2	1.7	-1.3	-0.9	1.0
Diastolic blood pressure, automated reading	0.1	0.2	0.5	0.3	0.2	-0.7
Ever depressed for a whole week	2.2	2.7	5.8	2.4	-0.8	-1.3
Unable to work because of sickness or disability	0.1	0.1	0.2	0.5	0.3	-0.2
Commuting to job workplace: Cycle	0.6	0.7	1.0	1.0	0.9	-0.6
Myopia	0.1	0.1	0.3	-0.3	0.2	0.5
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.8	0.5	0.5	-0.9
Cholesterol lowering medication	0.2	0.3	0.4	0.7	-0.3	0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.7	-0.3	0.4	-0.9
Pain experienced in last month	3.1	5.1	10.8	0.6	-3.3	2.1
Supplements: Calcium	0.9	1.0	1.7	1.3	1.1	-0.2
Basal cell carcinoma (self-reported)	0.7	0.8	1.8	1.3	0.5	0.7
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	-0.5	0.7	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.7	-1.9	-1.0	0.8
Heart disease (siblings)	1.3	1.7	3.0	-1.7	-1.2	-0.7
Alcohol drinker status: Previous	0.2	0.2	0.4	-0.7	-0.5	0.1
Pack years of smoking	0.3	0.4	1.1	-0.3	-1.0	0.2
Impedance of whole body	0.1	0.5	1.0	-1.0	0.4	-0.5
Leg fat mass (left)	0.0	0.2	0.2	-0.2	0.5	0.5
Arm predicted mass (left)	0.2	0.9	2.0	0.7	1.4	-0.2