Hub : Genes

SKP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.113	0.0370	3.7e-05	0.085	NA	0.075	NA	0.065	1.8e-07	NA	9.5e-07	NA	5.3e-06
2	GTEx	Nerve Tibial	0.157	0.0482	1.1e-05	0.165	NA	0.197	NA	0.200	9.5e-12	NA	6.2e-14	NA	3.8e-14
3	YFS	Blood	0.193	0.0287	0.0e+00	0.182	0.167	0.184	0.199	0.200	4.1e-57	2.2e-52	7.6e-58	4.6e-63	1.8e-63

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.2	0.4	-0.7	0.0	0.3
Bipolar Disorder or Schizophrenia	0.0	0.0	0.0	-0.0	0.1	-0.0
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.4	0.4	-0.6
Depression (Nagel 2018)	0.1	0.1	0.2	-0.5	0.3	-0.1
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.3	-0.1	-0.6	-0.1
Neuroticism (Nagel 2018)	0.1	0.2	0.3	-0.5	-0.6	-0.0
Schizophrenia (2018)	0.1	0.1	0.3	0.5	0.0	-0.2
Schizophrenia vs Biploar Disorder	0.2	0.2	0.6	-0.4	0.0	0.8
Worry (Nagel 2018)	1.3	2.7	3.8	-1.7	-2.0	1.2
Alzheimer’s Disease (in mother)	0.1	0.2	0.2	-0.5	-0.2	0.4
Alzheimer’s Disease (in father)	0.5	0.5	0.7	0.8	0.8	-0.5
Alzheimer’s Disease (including proxy)	0.1	0.1	0.1	-0.4	-0.2	0.3
Crohns Disease (2017)	2.5	5.4	9.2	-1.8	-1.9	3.0
Irritable Bowel Disease (IBD)	2.0	4.9	10.6	-1.6	-1.2	3.3
Ulcerative Colitis (UC)	1.0	1.9	4.6	-1.0	-0.0	2.1
Major Depression (MDD)	0.2	0.2	0.5	0.7	-0.0	0.2
Reaction Time	2.7	5.2	9.0	-2.1	-1.5	3.0
Verbal and Numeric Reasoning (VNR)	0.3	0.7	0.9	-0.9	-0.9	0.7
Breast Cancer	0.1	0.1	0.2	0.2	-0.4	-0.4
Ovarian Cancer	0.5	0.6	1.0	-1.0	-0.8	0.6
Prostate Cancer	3.1	4.4	4.6	-2.0	-2.1	2.1
Age at First Birth	1.2	1.7	3.3	-1.8	-1.2	0.7
Bipolar Disorder (2011)	1.7	1.7	2.6	1.6	0.0	-1.6
Body Mass Index (BMI) (2010)	0.5	0.6	1.0	0.2	0.9	-1.0
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.4	0.0	0.2
Crohns Disease (2012)	0.3	0.5	1.3	0.3	0.0	1.1
Mean Putamen Volume	0.3	0.4	0.5	-0.5	-0.7	0.6
Fasting Glucose	0.0	0.0	0.1	-0.2	0.0	0.1
HbA1C	0.7	0.8	1.1	1.0	0.5	-1.0
HDL Cholesterol	0.2	0.4	0.4	-0.5	-0.7	0.6
LDL Cholesterol	0.9	1.3	2.5	-1.2	-0.5	1.6
Lupus	6.9	10.4	13.0	3.6	3.2	-2.8
Neuroticism (2016)	0.1	0.2	0.4	0.6	0.2	-0.4
Primary Biliary Cirrhosis	0.0	0.0	0.1	-0.3	0.2	-0.0
Rheumatoid Arthritis	2.1	3.0	3.5	1.4	1.8	-1.9
Schizophrenia (2014)	0.3	0.7	1.2	1.1	0.0	-1.0
Triglycerides	0.4	0.6	1.3	0.7	1.1	-0.3
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	-0.2	0.0	0.5
Ulcerative Colitis	1.4	2.1	5.7	-0.8	0.0	2.4
Blood Eosinophil Count	2.3	17.5	28.7	5.4	4.1	-2.7
Blood Platelet Count	0.0	0.4	1.1	-1.0	-0.1	0.4
Blood Red Count	0.0	0.4	0.7	0.5	-0.5	0.8
Blood White Count	0.1	0.9	1.4	1.1	1.2	-0.3
Heel T-Score	3.0	23.7	36.5	4.2	4.1	-6.0
BMI	0.3	1.9	2.2	1.2	1.5	-1.4
Height	0.0	0.5	1.1	0.3	-0.5	-1.0
Waist Hip Ratio (WHR)	0.7	3.2	7.0	-0.7	-1.5	2.6
Systolic Blood Pressure	0.2	0.9	1.4	1.2	1.0	-0.6
Smoking Status	0.4	1.0	2.0	-1.0	-0.5	1.4
Allergy or Eczema	1.5	3.9	6.0	-1.7	-2.4	1.6
Cardiovascular Disease	0.7	2.2	2.8	1.5	1.7	-1.2
Hypothyroidism (self reported)	1.6	3.6	7.4	2.7	1.6	-0.8
Respiratory disease	0.8	1.8	3.8	-0.8	-1.0	2.0
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.3	1.2	0.4	-0.2
Lung FEV1/FVC ratio	0.1	0.5	1.3	-1.1	-0.0	-0.5
Lung FVC	0.2	1.0	2.9	-0.4	0.0	-1.7
Neuroticism	0.0	0.1	0.3	0.0	-0.5	0.1
Chronotype (morning person)	0.2	0.4	1.2	0.2	-1.1	-0.1
Hair Pigment	0.2	4.3	5.2	-1.8	-2.3	2.1
Tanning	0.1	1.2	1.8	1.1	1.4	-0.7
Hand grip strength (left)	0.0	0.1	0.2	0.4	-0.1	-0.3
Number of treatments/medications taken	1.0	1.8	2.7	-1.1	-1.6	1.2
Average weekly spirits intake	0.3	0.3	0.6	0.5	0.8	0.3
Sensitivity / hurt feelings	0.1	0.2	0.2	-0.5	-0.4	0.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.0	0.3	-0.4
Hearing difficulty/problems: Yes	0.0	0.1	0.1	0.4	-0.2	0.1
Relative age of first facial hair	0.5	1.0	2.2	-0.0	-0.8	1.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	-0.1	0.8	-0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	-0.5	-0.7	0.0
Ever had hysterectomy (womb removed)	0.6	0.7	1.9	1.4	0.4	-0.1
Systolic blood pressure, automated reading	0.4	1.1	1.6	1.0	0.9	-1.3
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.1	1.1	0.8	-1.0
Angina	0.3	0.4	1.1	-1.0	-0.4	0.2
Medication for hormone replacement therapy	0.0	0.0	0.1	0.3	0.1	0.1
Vitamin and mineral supplements	4.5	6.1	8.7	2.4	2.0	-3.0
Supplements: Zinc	0.6	0.6	1.0	-0.9	-0.1	1.0
Medication: Co-codamol	0.4	0.5	1.3	-1.2	-0.4	-0.2
Medication: Metformin	0.8	1.2	2.3	-0.2	-1.5	1.1
Diabetes (father)	0.2	0.2	0.5	-0.2	0.7	-0.0
Diabetes (mother)	0.1	0.1	0.1	0.3	0.3	-0.3
Severe depression (siblings)	0.6	0.7	1.2	0.5	0.8	-1.1
Pack years adult smoking proportion	0.2	0.3	0.8	0.3	0.9	0.3
Impedance of leg (right)	0.1	0.3	0.8	-0.4	-0.1	0.9
Leg fat-free mass (left)	0.4	2.4	4.7	1.4	0.6	-2.2
Trunk fat percentage	0.0	0.1	0.3	0.0	-0.3	0.5
Hand grip strength (right)	0.3	0.7	1.2	-0.4	-0.8	1.1
Townsend deprivation index at recruitment	0.4	0.5	0.8	0.9	0.9	-0.4
Current tobacco smoking	0.5	0.8	1.3	-1.1	-0.4	1.0
Average weekly fortified wine intake	1.4	1.7	3.0	0.9	1.1	-1.7
Maternal smoking around birth	0.3	0.4	0.5	0.6	-0.7	0.7
Fed-up feelings	0.8	1.4	1.9	1.1	1.1	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	-0.1	0.3	-0.1
Relative age voice broke	1.6	2.4	3.7	-1.1	-1.9	1.5
Taking other prescription medications	4.0	6.2	8.0	-2.5	-2.8	2.1
Age when periods started (menarche)	0.5	1.1	1.6	-0.7	-1.1	1.3
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.1	-0.3	-0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	2.6	6.0	6.8	2.6	2.3	-2.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.7	-0.1	0.2
Qualifications: CSEs or equivalent	0.6	0.8	1.2	1.0	0.3	-1.1
Serious illness, injury or assault to yourself	0.9	1.1	1.3	0.9	1.0	-1.1
High blood pressure	0.1	0.3	0.4	0.6	0.2	-0.7
Hayfever, allergic rhinitis or eczema	1.0	2.1	3.2	-0.9	-1.8	1.5
Multivitamins +/- minerals	1.3	1.6	2.1	-1.4	-0.8	1.4
Stomach or abdominal pain in last month	0.5	0.6	1.2	0.2	0.7	-1.1
Supplements: Glucosamine	0.2	0.3	0.7	0.0	0.4	-0.9
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.8	0.7	-0.1	-0.9
Medication: Atenolol	0.1	0.1	0.4	-0.2	0.1	-0.6
Medication: Levothyroxine sodium	0.4	0.7	1.8	1.3	0.3	0.5
Sitting height	0.3	2.1	3.3	1.5	0.9	-1.8
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	0.0	-0.7	-0.4
High blood pressure (mother)	0.3	0.4	0.4	-0.5	-0.7	0.6
Body mass index (BMI)	0.2	0.9	1.0	1.0	0.7	-1.0
Impedance of leg (left)	0.3	1.3	2.8	-1.0	-0.6	1.7
Leg predicted mass (left)	0.4	2.4	4.6	1.4	0.6	-2.1
Trunk fat mass	0.0	0.1	0.1	0.4	-0.3	0.0
Waist circumference	0.0	0.1	0.3	0.6	0.2	-0.2
Number of incorrect matches in round	0.0	0.0	0.1	-0.3	0.3	0.0
Past tobacco smoking	1.6	3.0	4.1	1.4	1.6	-2.0
Alcohol usually taken with meals	0.9	1.4	2.7	0.6	1.1	-1.6
Nervous feelings	0.1	0.1	0.2	-0.0	-0.5	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.1	-0.8	-1.0	0.9
Hearing difficulty/problems with background noise	0.5	0.8	1.4	1.2	0.3	-0.9
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	-0.2	0.5	0.7
Had menopause	2.8	3.5	5.4	2.3	1.8	-1.3
Had other major operations	3.4	4.2	5.7	-1.7	-2.4	2.0
Forced vital capacity (FVC)	0.1	0.4	1.2	0.2	-0.2	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	3.9	2.0	1.7	-1.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	0.9	-0.9	-0.7	0.7
Qualifications: None of the above	0.1	0.2	0.3	-0.4	-0.4	0.6
Financial difficulties in last 2 years	4.5	6.0	6.9	-2.5	-2.6	2.3
Mouth/teeth dental problems	1.8	2.8	3.9	-1.3	-2.0	1.7
Heart attack	1.2	1.6	2.2	-1.5	-1.4	0.8
Allergy	1.4	3.2	4.9	1.2	1.8	-2.2
Pain all over the body in last month	1.5	1.6	2.6	0.6	1.6	-1.4
Diabetes (self-reported)	0.3	0.4	0.9	-0.1	-0.6	1.0
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.0	0.1	-0.2	0.1
Medication: Ramipril	0.4	0.5	0.9	0.8	0.2	-0.9
Medication: Simvastatin	0.8	1.2	2.3	0.9	1.5	-0.6
Fluid intelligence score	0.1	0.3	0.7	-0.2	-0.8	-0.2
Illnesses of siblings	0.9	1.3	2.4	0.4	1.5	-1.2
Neuroticism score	0.1	0.1	0.2	-0.1	-0.4	0.4
Weight	0.2	1.2	2.0	1.1	0.4	-1.4
Impedance of arm (right)	1.2	5.6	9.5	-1.8	-2.0	3.1
Arm fat percentage (right)	0.0	0.2	0.3	-0.1	-0.6	0.4
Trunk fat-free mass	0.8	4.4	8.9	1.8	0.9	-3.0
Hip circumference	0.3	1.1	2.4	0.9	0.3	-1.5
Time employed in main current job	0.1	0.1	0.1	0.2	0.3	-0.2
Alcohol intake versus 10 years previously	0.0	0.0	0.0	0.0	-0.2	-0.1
Father’s age at death	0.1	0.1	0.4	-0.0	0.6	-0.3
Worrier / anxious feelings	0.1	0.1	0.3	0.1	-0.2	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.7	0.1	0.2
Falls in the last year	0.1	0.1	0.3	0.6	0.1	0.2
Hair/balding pattern: Pattern 3	0.8	1.2	1.7	1.3	1.2	-0.6
Number of live births	1.3	1.8	3.2	1.4	1.8	-0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.1	0.2	0.1	-1.0
Pulse rate	0.1	0.2	0.6	0.1	-0.2	0.8
Happiness	0.1	0.2	0.4	0.2	0.7	-0.2
Noisy workplace	0.2	0.3	0.4	0.5	0.4	-0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.3	1.1	1.1	-0.9
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	1.6	-0.8	-1.3	1.0
Mouth/teeth dental problems: Dentures	3.6	6.0	7.3	2.3	2.7	-2.3
Asthma	1.7	3.4	5.6	-1.2	-1.8	2.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.4	-0.5	-0.6	0.4
Medication: Cholesterol lowering	0.0	0.0	0.0	0.1	-0.1	0.1
Depression (self-reported)	0.1	0.1	0.1	0.4	-0.1	0.2
Medication: Lansoprazole	0.2	0.2	0.5	-0.7	-0.3	0.1
Prospective memory result	0.5	0.6	0.7	-0.8	-0.9	0.7
Lung cancer (father)	0.0	0.0	0.0	0.1	0.1	0.0
Illnesses of mother	2.6	3.3	3.9	-1.8	-1.6	2.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.9	0.4	0.4	-0.9
Pulse wave Arterial Stiffness index	3.0	3.5	5.5	-2.3	-2.0	1.1
Impedance of arm (left)	0.8	3.7	7.3	-1.4	-1.3	2.7
Arm fat mass (right)	0.1	0.4	0.6	0.7	0.0	-0.8
Trunk predicted mass	0.7	3.9	8.3	1.7	0.7	-2.9
Standing height	0.1	0.5	0.8	0.3	-0.9	-0.9
Length of working week for main job	0.1	0.1	0.2	0.4	0.2	-0.2
Exposure to tobacco smoke at home	0.8	0.9	2.1	0.6	1.4	-0.5
Breastfed as a baby	0.2	0.3	0.4	0.7	0.5	-0.4
Tense / ‘highly strung’	1.0	1.6	2.1	-1.2	-1.4	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.9	0.9	0.6	-0.7
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	-0.1	-0.5	-1.0
Birth weight of first child	0.1	0.1	0.3	0.5	-0.1	-0.3
Peak expiratory flow (PEF)	0.2	0.5	0.7	0.8	0.8	-0.4
Pulse wave reflection index	5.1	6.2	8.0	-2.8	-2.8	1.8
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	-0.0	0.0	0.2
Loud music exposure frequency	0.3	0.3	0.8	0.2	0.2	-0.9
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.2	0.8	0.6	-1.8
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	0.0	0.4	0.1
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.0	0.1	0.5
Medication: Paracetamol	0.1	0.2	0.5	0.7	-0.4	-0.2
Headache pain in last month	0.1	0.2	0.4	-0.5	-0.6	0.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	-0.6	0.2	-0.0
Glaucoma (self-reported)	0.0	0.0	0.0	-0.0	-0.1	0.1
Gout (self-reported)	4.3	5.8	7.6	-2.1	-2.4	2.8
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	6.8	2.6	1.6	-0.6
Medication: Amlodipine	0.2	0.3	0.7	-0.2	-0.8	-0.5
Medication: Ventolin 100micrograms inhaler	1.9	2.4	4.1	-1.7	-0.4	2.0
Birth weight	0.3	0.6	1.1	-0.0	1.0	-0.8
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.5	-0.4	-0.1
High blood pressure (siblings)	0.3	0.5	1.3	0.0	-1.1	0.4
Forced vital capacity (FVC), Best measure	0.1	0.3	0.9	0.2	0.1	-0.9
Body fat percentage	0.0	0.1	0.1	0.3	-0.0	0.3
Leg fat percentage (right)	0.0	0.1	0.2	0.4	0.4	-0.3
Arm fat-free mass (right)	1.4	7.2	12.7	2.4	1.8	-3.6
Exposure to tobacco smoke outside home	2.1	2.9	4.9	-1.2	-2.2	1.5
Comparative body size at age 10	0.1	0.4	0.7	-0.3	-0.9	-0.5
Number of full brothers	1.3	1.6	2.1	-1.1	-1.1	1.5
Worry too long after embarrassment	0.2	0.3	0.5	-0.7	-0.2	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.7	0.6	0.7	-0.8
Wheeze or whistling in the chest in last year	0.5	0.9	2.1	-0.3	-0.6	1.5
Number of children fathered	2.8	3.2	4.8	-1.6	-1.5	2.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.8	0.9	-0.1	-0.2
Age at first live birth	2.5	4.4	5.1	1.9	2.3	-2.2
Pulse wave peak to peak time	2.9	3.4	5.5	2.3	1.9	-1.1
Health satisfaction	0.5	0.6	1.0	0.3	0.9	-1.0
Shortness of breath walking on level ground	2.5	2.9	3.2	-1.8	-1.7	1.7
Qualifications: College or University degree	0.2	0.8	1.6	0.8	1.2	-0.1
Eye problems/disorders: None of the above	1.0	1.1	1.7	-0.6	-1.2	1.3
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	-0.5	0.8	0.0
Emphysema/chronic bronchitis	3.3	3.8	5.2	1.3	2.3	-2.1
Medication for pain relief, constipation, heartburn	0.3	0.6	1.0	-0.8	-0.3	1.0
Neck or shoulder pain in last month	0.3	0.5	0.8	-0.7	-0.4	-0.9
Medication: Blood pressure	0.1	0.3	0.4	0.6	-0.5	-0.4
Angina (self-reported)	0.3	0.4	0.9	-1.0	-0.4	0.2
Migraine (self-reported)	1.1	1.4	1.8	1.3	1.4	-0.7
Medication: Ibuprofen	0.0	0.0	0.0	-0.1	0.0	0.1
Medication: Allopurinol	1.5	2.1	2.3	-1.3	-1.5	1.5
Medication: Omeprazole	0.1	0.1	0.1	0.2	0.3	-0.3
Medication: Seretide 50 evohaler	0.3	0.3	0.7	0.1	-0.5	0.8
Mean time to correctly identify matches	2.6	4.9	7.5	-2.2	-1.5	2.7
Heart disease (mother)	4.0	4.8	6.7	2.6	2.1	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	3.0	-1.0	-1.4	1.7
Whole body fat mass	0.0	0.1	0.2	0.5	-0.1	-0.3
Leg fat mass (right)	0.1	0.4	0.5	0.7	0.4	-0.7
Arm predicted mass (right)	1.4	7.0	11.9	2.4	1.8	-3.5
Pulse rate, automated reading	0.3	0.9	1.5	1.2	0.8	-0.7
Alcohol intake frequency.	0.2	0.6	1.0	1.0	0.6	-0.6
Comparative height size at age 10	0.2	0.9	2.6	0.2	-1.6	0.2
Number of full sisters	1.7	2.1	2.8	-1.1	-1.5	1.7
Suffer from ‘nerves’	1.0	1.6	2.2	-1.5	-1.2	1.0
Overall health rating	0.0	0.1	0.2	-0.4	-0.1	-0.3
Chest pain or discomfort	0.9	1.3	1.8	-1.3	-1.3	0.7
Had major operations	0.6	0.7	0.9	-0.9	-0.9	-0.6
Age at last live birth	0.4	0.6	1.5	1.2	0.5	-0.1
Family relationship satisfaction	0.4	0.4	0.7	0.8	0.8	-0.0
Leg pain on walking	0.9	1.1	2.2	-0.8	-1.5	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.0	0.0	-0.5
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.4	-0.7	-1.0	1.2
Illness, injury, bereavement, stress in last 2 years	3.4	4.1	5.7	1.4	2.2	-2.4
Medication: Aspirin	0.6	0.8	1.3	0.8	0.6	-1.1
Supplements: Vitamin C	3.6	4.2	5.8	-1.5	-2.1	2.4
Knee pain experienced in last month	0.4	0.6	1.3	-0.3	-1.2	0.6
Hypertension (Self-reported)	0.0	0.1	0.3	0.6	0.1	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	-0.0	0.4	-0.7
Illnesses of father: Heart disease	1.2	1.7	2.8	1.7	0.1	-1.5
Illnesses of siblings: Diabetes	1.0	1.2	2.2	-1.0	-0.7	1.5
Smoking status: Previous	0.2	0.3	0.6	-0.1	-0.5	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	0.1	-0.2	0.4
Whole body fat-free mass	0.7	4.1	8.2	1.8	1.0	-2.9
Leg fat-free mass (right)	0.3	1.6	3.3	1.1	0.3	-1.8
Arm fat percentage (left)	0.0	0.0	0.1	0.3	-0.0	0.1
Average weekly red wine intake	0.9	1.3	2.5	0.8	1.6	-0.9
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.3	-0.4	0.1
Mood swings	0.5	0.9	1.1	1.0	1.0	-0.8
Loneliness, isolation	0.2	0.2	0.6	-0.1	0.3	-0.8
Long-standing illness, disability or infirmity	2.1	3.1	4.2	-1.8	-2.0	1.4
Ever had bowel cancer screening	0.2	0.2	0.3	0.6	0.5	-0.2
Diabetes diagnosed by doctor	0.8	1.3	2.2	-0.2	-1.3	1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.0	-0.5	-0.6	1.0
Friendships satisfaction	0.6	0.7	1.1	0.6	0.8	-1.0
Qualifications: nursing, teaching	0.1	0.2	0.3	-0.3	-0.4	0.5
Commuting to job workplace: Walk	0.2	0.2	0.7	0.0	-0.0	-0.8
Eye problems/disorders: Cataract	2.0	2.3	3.8	0.9	1.5	-2.0
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.4	-0.5	-1.6	0.5
Medication for cholesterol	0.6	1.0	1.9	-0.7	-1.4	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.8	-0.2	0.1	0.9
Back pain experienced in last month	3.5	5.1	9.2	-2.2	-3.0	1.0
Mineral and other dietary supplements	2.1	2.8	3.3	1.5	1.6	-1.8
Breast cancer (self-reported)	0.2	0.2	0.4	0.6	-0.3	-0.3
Asthma (self-reported)	2.1	4.3	6.6	-1.5	-2.0	2.6
Osteoporosis (self-reported)	1.6	2.0	2.6	-1.1	-1.6	1.5
Osteoarthritis (self-reported)	1.7	2.2	3.3	0.4	1.7	-1.8
Medication: Aspirin	0.8	1.0	1.2	1.1	0.9	-1.1
Medication: Gliclazide	0.4	0.5	1.0	-0.5	-1.0	0.5
Illnesses of father: None of the above (group 1)	0.1	0.2	0.5	-0.3	-0.0	0.7
Smoking status: Current	0.7	1.1	1.6	-1.3	-0.6	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.2	0.1	-0.1	-0.5
Whole body water mass	0.7	4.2	8.4	1.8	1.0	-2.9
Leg predicted mass (right)	0.3	1.6	3.3	1.2	0.3	-1.8
Arm fat mass (left)	0.1	0.4	0.7	0.6	0.2	-0.8
Number of self-reported non-cancer illnesses	0.5	0.9	2.1	-0.3	-1.5	0.7
Average weekly champagne plus white wine intake	0.8	1.0	1.5	1.1	0.7	-1.2
Miserableness	0.1	0.1	0.2	0.0	0.4	-0.3
Guilty feelings	0.3	0.4	0.8	0.6	0.1	0.9
Wears glasses or contact lenses	0.4	0.5	0.7	-0.4	-0.8	0.8
Ever taken oral contraceptive pill	0.1	0.1	0.1	-0.1	0.4	0.3
Hearing aid user	0.4	0.5	0.9	0.5	1.0	-0.6
Mother’s age at death	0.1	0.1	0.2	0.1	0.3	-0.4
Financial situation satisfaction	2.1	2.6	3.3	-1.8	-1.3	1.7
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.4	0.1	0.2	0.7
Commuting to job workplace: Public transport	6.4	7.6	9.1	2.2	3.0	-2.9
Eye problems/disorders: Glaucoma	0.0	0.0	0.0	-0.2	-0.2	-0.2
Medication: Blood pressure	0.1	0.2	0.5	-0.1	0.7	-0.2
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.0	-1.4	-1.4	0.5
Supplements: Fish oil (including cod liver oil)	1.7	2.2	3.8	-1.1	-1.2	1.9
High cholesterol (Self-reported)	0.6	1.1	1.9	1.4	0.9	-0.8
Medication: Bendroflumethiazide	0.2	0.3	0.6	0.5	0.3	-0.8
Medication: Paracetamol	0.1	0.2	0.5	-0.1	-0.7	0.3
Medication: Lisinopril	1.4	1.8	3.0	-0.9	-1.7	1.3
Medication: Atorvastatin	1.1	1.4	3.3	1.8	0.4	-0.8
Illnesses of father: High blood pressure	0.0	0.0	0.1	0.2	-0.0	-0.3
Alcohol drinker status: Never	2.1	2.5	4.2	2.1	1.5	-1.1
Ever smoked	4.3	7.6	9.0	-2.7	-2.5	3.0
Basal metabolic rate	0.6	3.3	6.7	1.6	0.8	-2.6
Leg fat percentage (left)	0.0	0.0	0.0	0.1	0.1	0.2
Arm fat-free mass (left)	0.9	4.7	9.4	1.7	1.2	-3.1
Number of operations (self-reported)	0.2	0.2	0.4	-0.5	-0.6	-0.3
Average weekly beer plus cider intake	0.1	0.2	0.4	0.6	0.4	0.2
Irritability	0.2	0.3	0.7	0.4	0.0	-0.8
Risk taking	0.1	0.1	0.4	0.1	-0.2	0.6
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	-0.0	-0.2	-0.3
Fractured/broken bones in last 5 years	0.2	0.2	0.6	-0.0	-0.1	0.8
Age started oral contraceptive pill	0.6	0.8	1.5	1.2	0.4	-0.8
Diastolic blood pressure, automated reading	0.3	1.0	2.2	1.5	0.4	-0.9
Ever depressed for a whole week	0.3	0.3	0.4	-0.6	-0.7	0.4
Unable to work because of sickness or disability	0.6	0.8	1.3	0.7	1.2	-0.8
Commuting to job workplace: Cycle	2.8	3.3	4.2	1.8	1.6	-2.0
Myopia	0.3	0.5	0.7	0.8	0.5	-0.6
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.6	-0.6	-0.5	0.8
Cholesterol lowering medication	0.3	0.5	0.8	0.9	0.8	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.1	0.2	0.1	-0.3
Pain experienced in last month	0.2	0.4	0.6	0.8	0.8	0.1
Supplements: Calcium	4.2	4.6	5.3	-2.3	-2.0	2.1
Basal cell carcinoma (self-reported)	0.3	0.4	1.0	1.0	0.0	-0.4
Heart attack/myocardial infarction (self-reported)	1.0	1.3	1.8	-1.4	-1.3	0.7
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	0.2	0.5	0.1
Heart disease (siblings)	0.0	0.0	0.1	0.2	0.3	-0.1
Alcohol drinker status: Previous	0.2	0.2	0.5	-0.0	0.7	0.3
Pack years of smoking	0.5	0.7	1.6	0.7	1.3	-0.0
Impedance of whole body	0.6	3.3	6.5	-1.5	-1.1	2.5
Leg fat mass (left)	0.1	0.3	0.4	0.7	0.3	-0.6
Arm predicted mass (left)	1.1	5.4	10.4	1.9	1.4	-3.2