Hub : Genes

PPARD

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.3710 0.1040 0.00011 0.062 NA 0.110 NA 0.134 0.00670 NA 0.00039 NA 9.3e-05
2 METSIM Adipose 0.0391 0.0198 0.00730 0.000 0.003 0.013 0.006 0.002 0.38000 0.1100 0.00390 0.035 1.6e-01
3 TCGA Kidney Renal Papillary Cell Carcinoma 0.0700 0.0370 0.00220 0.056 0.036 0.014 NA 0.040 0.00037 0.0036 0.05100 NA 2.5e-03
4 TCGA Testicular Germ Cell Tumors 0.1200 0.0620 0.00210 0.100 0.020 0.011 NA 0.055 0.00022 0.0630 0.13000 NA 5.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.5 0.7 1.7 -1.3 0.9 0.5 -0.6
Bipolar Disorder or Schizophrenia 0.2 0.5 0.8 -0.9 -0.4 -0.8 0.6
Depressed Affect (Nagel 2018) 0.3 0.6 1.0 -0.7 1.0 1.0 0.2
Depression (Nagel 2018) 0.6 0.9 1.9 -1.4 -0.3 -0.4 1.2
Intelligence (Savage-Jansen 2018) 0.7 2.3 8.1 2.9 0.7 0.4 0.6
Neuroticism (Nagel 2018) 1.1 2.6 8.6 -1.1 0.7 -0.4 2.9
Schizophrenia (2018) 0.5 1.1 2.0 -0.1 -1.1 -1.4 1.2
Schizophrenia vs Biploar Disorder 0.6 0.8 1.3 -0.0 -1.2 -0.7 1.1
Worry (Nagel 2018) 1.8 3.8 10.2 -1.8 -0.7 -1.1 3.2
Alzheimer’s Disease (in mother) 1.6 1.8 5.6 0.5 -0.6 -1.1 2.4
Alzheimer’s Disease (in father) 0.7 0.8 1.5 0.4 -1.2 -0.5 1.1
Alzheimer’s Disease (including proxy) 1.5 2.2 5.5 0.7 -1.6 -0.5 2.3
Crohns Disease (2017) 0.7 1.4 3.9 2.0 -0.5 1.2 0.3
Irritable Bowel Disease (IBD) 0.7 1.8 5.6 1.0 0.6 -0.1 2.4
Ulcerative Colitis (UC) 2.1 3.9 11.5 -0.3 1.4 -1.4 3.4
Major Depression (MDD) 0.5 0.6 1.3 0.2 -0.4 1.1 -1.0
Reaction Time 0.4 0.7 1.6 -1.3 0.2 1.0 -0.4
Verbal and Numeric Reasoning (VNR) 0.5 1.1 1.8 1.3 -0.3 -0.8 1.3
Breast Cancer 1.0 2.4 5.1 -2.3 0.7 -0.9 1.8
Ovarian Cancer 0.6 0.8 2.0 -0.2 0.3 -1.4 0.9
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.6 2.3 6.6 0.1 -1.4 -0.7 2.6
Bipolar Disorder (2011) 2.7 2.6 7.3 -2.7 1.4 -1.1 -0.2
Body Mass Index (BMI) (2010) 1.4 2.0 7.2 -0.2 -0.1 0.8 -2.7
Coronary Artery Disease (CAD) 1.4 1.6 3.1 0.9 1.6 1.8 -0.4
Crohns Disease (2012) 0.6 0.9 2.6 1.6 -0.4 0.7 0.6
Mean Putamen Volume 0.6 0.7 2.2 0.0 -1.5 0.3 -0.7
Fasting Glucose 0.4 0.5 1.5 1.2 0.2 0.7 0.0
HbA1C 1.4 1.5 3.0 -0.8 1.1 -1.2 1.7
HDL Cholesterol 1.3 2.2 3.7 1.8 -1.2 1.9 -0.8
LDL Cholesterol 1.9 3.1 5.0 2.2 -0.1 1.8 -2.0
Lupus 4.2 6.3 12.5 1.6 0.7 3.1 -3.5
Neuroticism (2016) 0.7 1.0 2.1 -0.3 -0.8 1.5 1.1
Primary Biliary Cirrhosis 2.8 4.0 9.0 2.2 3.0 0.5 -1.4
Rheumatoid Arthritis 0.7 0.9 2.4 -1.6 0.9 -0.4 -0.5
Schizophrenia (2014) 0.1 0.3 0.7 0.0 -0.9 -0.5 0.3
Triglycerides 1.1 1.8 3.2 1.2 1.5 0.5 -1.8
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.8 0.9 1.4 0.2 0.8
Ulcerative Colitis 2.0 3.0 7.4 0.8 2.7 -0.8 1.8
Blood Eosinophil Count 3.3 25.1 70.5 -1.8 8.4 -2.9 4.3
Blood Platelet Count 2.1 24.3 85.2 0.2 0.4 -3.5 9.2
Blood Red Count 0.5 4.8 14.0 0.8 -3.7 2.1 -0.0
Blood White Count 3.4 24.9 42.6 -3.3 -5.0 -4.6 6.5
Heel T-Score 1.2 9.3 27.2 1.5 -1.8 -2.1 5.2
BMI 2.7 15.7 26.8 0.9 3.9 4.5 -5.2
Height 5.0 96.6 225.0 -12.5 -2.2 -15.0 -0.2
Waist Hip Ratio (WHR) 0.5 2.3 7.0 0.8 1.0 0.9 2.6
Systolic Blood Pressure 0.9 4.4 8.3 -2.6 -1.5 0.7 2.9
Smoking Status 1.9 4.5 5.6 2.3 2.4 1.5 -2.1
Allergy or Eczema 0.5 1.3 4.5 0.8 2.1 -0.2 -0.0
Cardiovascular Disease 1.0 3.4 8.4 1.0 2.9 1.9 -0.5
Hypothyroidism (self reported) 1.5 3.4 7.6 -2.8 2.2 -0.9 -0.0
Respiratory disease 3.1 6.9 8.0 2.8 2.8 2.8 -2.1
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.4 0.1 0.8 -0.6 1.5
Lung FEV1/FVC ratio 1.7 8.9 16.2 -2.7 -1.4 -4.0 3.2
Lung FVC 1.9 9.8 32.0 -1.5 -5.7 -1.1 1.9
Neuroticism 0.5 1.1 3.1 -0.8 1.0 0.1 1.8
Chronotype (morning person) 0.8 1.9 5.8 -1.1 -2.4 -0.1 -0.7
Hair Pigment 0.4 12.7 24.3 -4.9 -0.9 -2.9 4.2
Tanning 0.1 1.5 3.7 1.9 1.1 -0.4 -1.0
Hand grip strength (left) 2.6 6.9 15.4 -1.9 -2.5 -3.9 1.5
Number of treatments/medications taken 1.9 3.4 8.8 1.1 3.0 1.8 -0.6
Average weekly spirits intake 2.3 2.8 8.7 0.0 2.9 1.5 -0.7
Sensitivity / hurt feelings 2.4 4.2 12.2 -1.1 0.6 -1.7 3.5
Frequency of depressed mood in last 2 weeks 0.7 1.0 3.3 -0.7 -1.8 0.1 0.5
Hearing difficulty/problems: Yes 1.1 1.6 2.9 -1.0 1.7 -1.3 1.0
Relative age of first facial hair 1.4 2.8 8.5 -0.5 0.3 -2.9 1.5
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 2.2 0.4 1.2 -0.3 -1.5
Ever used hormone-replacement therapy (HRT) 0.5 0.7 1.9 0.6 1.4 0.7 -0.1
Ever had hysterectomy (womb removed) 1.0 1.1 1.6 1.1 0.8 1.3 -0.9
Systolic blood pressure, automated reading 0.7 2.0 5.4 -2.3 0.2 0.7 1.4
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 3.0 -1.7 -1.0 -0.8 0.2
Angina 1.5 2.0 5.0 -2.2 1.2 1.2 0.4
Medication for hormone replacement therapy 0.4 0.5 1.0 -0.2 -0.9 -0.1 1.0
Vitamin and mineral supplements 0.6 0.8 1.8 -0.9 -1.3 0.4 -0.5
Supplements: Zinc 0.4 0.5 0.9 0.9 -0.7 -0.7 0.1
Medication: Co-codamol 1.3 1.5 2.7 0.5 -0.9 1.5 -1.6
Medication: Metformin 0.2 0.3 0.4 0.6 0.3 -0.6 0.6
Diabetes (father) 0.5 0.6 1.8 -1.3 0.5 -0.4 -0.3
Diabetes (mother) 0.9 1.1 2.2 0.1 -1.4 -1.5 0.6
Severe depression (siblings) 0.5 0.5 0.8 -0.9 -0.8 -0.2 0.8
Pack years adult smoking proportion 1.0 1.5 4.3 0.1 -0.9 2.1 -0.8
Impedance of leg (right) 2.1 9.9 15.5 -3.0 1.3 -3.7 3.9
Leg fat-free mass (left) 1.2 6.4 17.1 -2.4 -0.3 -1.6 -4.1
Trunk fat percentage 4.8 19.1 52.0 -2.3 7.2 -0.1 -4.4
Hand grip strength (right) 2.4 6.4 14.4 -2.0 -1.9 -3.8 1.9
Townsend deprivation index at recruitment 1.9 2.7 3.9 1.8 -1.1 1.6 -2.0
Current tobacco smoking 0.5 0.8 1.8 1.4 0.9 0.4 -0.6
Average weekly fortified wine intake 0.7 0.8 2.2 1.5 0.6 0.1 -0.7
Maternal smoking around birth 1.9 2.7 7.0 1.5 0.6 2.6 -1.1
Fed-up feelings 0.4 0.8 1.8 -0.7 1.3 1.0 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 1.8 -0.8 0.9 -0.7 1.3
Relative age voice broke 1.4 2.1 3.8 -1.9 -0.2 -1.7 1.3
Taking other prescription medications 0.5 0.8 2.3 0.0 1.5 0.1 0.8
Age when periods started (menarche) 0.8 1.9 2.7 1.1 1.4 -1.3 1.6
Bilateral oophorectomy (both ovaries removed) 1.7 2.0 6.5 -0.3 -0.6 -1.0 2.5
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.3 11.1 -0.3 0.3 -1.4 3.3
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 1.3 0.4 -1.1 0.3 -0.8
Qualifications: CSEs or equivalent 1.6 2.1 4.9 0.2 0.5 2.2 -1.7
Serious illness, injury or assault to yourself 0.7 0.8 2.8 -0.2 1.7 -0.3 0.6
High blood pressure 0.5 1.4 2.5 0.8 1.6 1.3 0.9
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.0 0.6 1.0 1.0 -0.7
Multivitamins +/- minerals 0.3 0.4 0.9 0.9 0.1 0.8 -0.3
Stomach or abdominal pain in last month 0.4 0.4 1.3 -0.3 -0.3 0.5 -1.1
Supplements: Glucosamine 0.7 1.0 2.9 1.7 0.6 -0.7 -0.4
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.1 -0.4 -1.0 0.2 0.4
Medication: Atenolol 1.3 1.7 4.0 -0.5 2.0 1.3 -0.9
Medication: Levothyroxine sodium 0.6 1.1 3.2 -1.8 1.0 -0.2 0.3
Sitting height 1.5 10.5 25.9 -5.1 -0.9 -3.0 -2.5
Chronic bronchitis/emphysema (father) 0.5 0.5 1.4 0.3 0.4 0.7 1.2
High blood pressure (mother) 1.9 2.7 6.4 1.1 -2.5 1.6 -0.8
Body mass index (BMI) 2.7 11.5 22.5 0.7 3.3 3.5 -4.7
Impedance of leg (left) 1.7 8.4 11.2 -2.6 2.2 -3.3 3.3
Leg predicted mass (left) 1.2 6.3 17.0 -2.3 -0.4 -1.6 -4.1
Trunk fat mass 3.6 15.6 32.5 -2.8 5.7 -0.8 -4.6
Waist circumference 1.9 7.0 15.7 -0.8 2.9 1.7 -4.0
Number of incorrect matches in round 1.6 2.6 4.1 -2.0 -0.7 -2.0 1.4
Past tobacco smoking 1.9 3.5 8.1 -0.5 -1.1 -2.1 2.8
Alcohol usually taken with meals 0.8 1.4 2.9 -1.7 -1.1 -1.1 0.5
Nervous feelings 0.5 1.0 1.9 -0.6 -1.3 0.2 1.4
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.8 0.2 -0.1 0.9 -0.2
Hearing difficulty/problems with background noise 1.1 1.8 4.4 -2.1 -0.1 -1.6 0.7
Hair/balding pattern: Pattern 2 1.3 1.6 3.5 1.4 1.9 0.6 -0.8
Had menopause 0.2 0.2 0.5 -0.3 0.6 -0.1 -0.7
Had other major operations 0.6 0.7 2.6 -0.3 -1.6 0.4 0.1
Forced vital capacity (FVC) 4.1 15.6 22.4 -4.2 -4.7 -4.6 0.9
Heel bone mineral density (BMD) T-score, automated (right) 1.9 4.3 13.0 -0.6 -0.4 -2.0 3.6
Ever unenthusiastic/disinterested for a whole week 4.6 5.6 10.6 -3.3 -3.2 -0.7 1.1
Qualifications: None of the above 0.8 1.8 4.0 -1.0 2.0 0.6 -1.3
Financial difficulties in last 2 years 0.4 0.5 0.9 0.9 0.2 0.5 -0.9
Mouth/teeth dental problems 0.8 1.2 3.2 -1.8 -0.5 -1.1 -0.4
Heart attack 2.4 3.1 8.9 -1.5 3.0 0.7 -0.7
Allergy 1.3 2.9 5.0 -1.3 -2.2 -1.8 1.4
Pain all over the body in last month 0.5 0.6 1.6 0.1 0.7 0.4 1.3
Diabetes (self-reported) 0.4 0.6 1.6 -0.2 0.6 -0.5 1.3
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.5 -0.0 -0.7 0.6 0.2
Medication: Ramipril 1.8 2.3 4.7 2.2 1.3 1.6 0.5
Medication: Simvastatin 1.5 2.2 4.4 2.1 1.4 1.4 -0.5
Fluid intelligence score 0.5 1.0 1.6 0.5 -0.9 -1.3 1.1
Illnesses of siblings 0.5 0.8 1.4 -1.0 -0.8 -0.2 -1.2
Neuroticism score 0.3 0.7 2.4 -0.6 0.1 -0.1 1.5
Weight 1.8 9.0 21.9 -2.8 2.2 -1.1 -4.7
Impedance of arm (right) 2.2 10.5 18.1 -2.3 3.2 -4.3 2.9
Arm fat percentage (right) 3.3 13.1 29.3 -0.6 5.4 2.1 -4.3
Trunk fat-free mass 1.5 8.5 11.4 -2.8 -3.4 -2.9 -2.6
Hip circumference 1.9 8.3 23.5 -2.1 2.2 -0.4 -4.8
Time employed in main current job 1.7 2.0 5.3 -2.3 1.3 -0.0 -0.9
Alcohol intake versus 10 years previously 1.9 2.8 4.5 -1.6 -0.4 -2.1 2.0
Father’s age at death 0.4 0.6 1.2 -1.1 -0.4 -0.9 0.4
Worrier / anxious feelings 4.5 8.6 16.3 -2.7 0.7 -3.2 4.0
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 0.8 -0.9 0.7 -0.7 0.7
Falls in the last year 1.4 1.9 6.8 0.7 0.0 0.4 -2.6
Hair/balding pattern: Pattern 3 0.6 0.9 3.0 0.2 -1.7 -0.5 0.2
Number of live births 2.5 3.6 5.9 1.7 0.8 2.3 -2.4
Forced expiratory volume in 1-second (FEV1) 5.2 17.7 25.7 -4.2 -5.0 -5.1 1.6
Pulse rate 0.2 0.4 1.1 0.2 0.6 1.1 0.3
Happiness 1.0 1.2 2.1 -1.1 -1.4 -1.0 0.7
Noisy workplace 1.0 1.2 3.5 1.9 0.4 -0.0 1.1
Qualifications: A levels/AS levels or equivalent 1.1 2.5 5.8 0.5 -1.2 -1.6 2.4
Serious illness, injury or assault of a close relative in last 2 years 1.9 2.2 4.2 0.4 -1.3 -2.1 1.6
Mouth/teeth dental problems: Dentures 0.4 0.7 1.9 0.8 0.1 1.4 -0.3
Asthma 3.6 7.0 9.9 2.8 2.3 3.2 -2.3
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 3.1 0.0 1.8 0.5 -0.6
Medication: Cholesterol lowering 1.2 1.9 5.7 0.4 2.4 1.2 -0.6
Depression (self-reported) 1.1 1.3 2.6 -1.6 -1.4 -0.5 0.7
Medication: Lansoprazole 0.3 0.3 0.8 -0.9 0.4 -0.1 0.5
Prospective memory result 0.7 0.8 2.4 -0.6 1.6 0.1 0.6
Lung cancer (father) 1.6 1.9 3.3 -0.8 1.5 -1.2 1.8
Illnesses of mother 1.5 1.8 3.5 -1.9 -0.9 -1.7 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 6.0 19.1 29.8 -4.1 -5.0 -5.5 2.2
Pulse wave Arterial Stiffness index 0.8 0.9 1.4 0.5 1.1 -0.8 -1.2
Impedance of arm (left) 2.6 11.9 20.4 -3.0 3.4 -4.5 2.5
Arm fat mass (right) 2.6 10.9 22.9 -1.3 4.3 0.9 -4.8
Trunk predicted mass 1.5 8.4 11.5 -2.8 -3.4 -2.8 -2.5
Standing height 4.2 41.4 100.0 -7.8 -2.1 -10.0 -0.3
Length of working week for main job 0.9 1.0 1.8 -0.5 -1.1 1.4 -0.7
Exposure to tobacco smoke at home 5.1 5.7 10.0 2.0 -0.8 2.9 -3.2
Breastfed as a baby 1.6 2.0 5.4 -1.2 1.0 -2.3 0.1
Tense / ‘highly strung’ 0.4 0.7 1.5 -1.2 0.0 -0.5 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.2 7.8 -1.0 -2.8 0.0 0.2
Hair/balding pattern: Pattern 4 1.8 4.4 11.4 -1.6 -1.9 -0.3 3.4
Birth weight of first child 2.6 4.6 11.9 -1.0 -3.4 -1.8 1.6
Peak expiratory flow (PEF) 4.1 9.6 12.5 -3.3 -3.0 -3.5 2.4
Pulse wave reflection index 0.4 0.5 1.1 1.0 0.1 -0.1 -1.1
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.4 -0.4 -0.6 -0.3 0.2
Loud music exposure frequency 0.0 0.0 0.1 0.0 0.1 -0.1 -0.3
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 3.1 -0.1 -1.3 -0.7 1.8
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 2.3 1.5 0.1 0.0 0.6
Blood clot in the leg (DVT) 0.9 1.2 3.9 0.1 2.0 -0.9 -0.4
Medication: Paracetamol 1.2 2.0 5.5 0.2 2.4 1.1 -1.1
Headache pain in last month 0.2 0.3 0.8 0.6 0.9 0.3 -0.2
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 4.0 0.1 -2.0 -0.4 -0.6
Glaucoma (self-reported) 0.9 1.1 2.6 -1.1 1.6 -0.7 0.4
Gout (self-reported) 1.6 2.3 8.6 0.1 2.9 0.4 0.6
Hypothyroidism/myxoedema (self-reported) 1.4 2.8 6.8 -2.6 1.8 -1.1 0.3
Medication: Amlodipine 0.8 1.1 2.8 -0.0 1.2 -0.3 1.7
Medication: Ventolin 100micrograms inhaler 0.8 1.1 2.2 1.5 1.2 0.7 0.4
Birth weight 0.8 1.7 3.6 -0.6 -1.2 -1.9 1.2
Chronic bronchitis/emphysema (mother) 2.9 3.4 7.6 2.0 2.8 1.3 -0.6
High blood pressure (siblings) 0.1 0.1 0.2 0.5 0.4 0.2 0.3
Forced vital capacity (FVC), Best measure 4.3 15.7 23.4 -3.9 -4.7 -4.8 1.3
Body fat percentage 4.4 17.3 45.0 -1.9 6.7 0.9 -4.5
Leg fat percentage (right) 3.4 12.5 24.1 -1.0 4.9 2.4 -4.4
Arm fat-free mass (right) 1.3 6.4 14.5 -2.4 -1.8 -1.6 -3.8
Exposure to tobacco smoke outside home 0.5 0.6 1.4 0.2 1.2 -0.8 -0.6
Comparative body size at age 10 3.1 8.4 16.5 1.6 -1.6 4.1 -3.5
Number of full brothers 0.5 0.7 1.4 1.2 0.9 0.7 -0.3
Worry too long after embarrassment 1.4 2.4 8.6 -0.2 0.6 -0.8 2.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.0 -0.4 -1.0 0.1 0.7
Wheeze or whistling in the chest in last year 2.2 3.9 8.4 1.6 2.9 1.5 -1.5
Number of children fathered 1.1 1.3 3.3 -1.2 1.8 -0.6 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 0.8 0.7 0.6 -0.1 -0.9
Age at first live birth 1.9 3.4 10.0 -0.5 -1.0 -1.6 3.2
Pulse wave peak to peak time 0.7 0.8 1.2 -0.9 -1.1 0.1 1.1
Health satisfaction 1.0 1.2 2.9 0.8 0.5 1.1 -1.7
Shortness of breath walking on level ground 1.8 2.1 3.3 -0.4 1.8 1.6 -1.5
Qualifications: College or University degree 0.8 2.5 6.0 1.4 -0.5 -2.4 1.3
Eye problems/disorders: None of the above 0.4 0.5 1.8 0.2 -1.4 0.0 -0.1
Mouth/teeth dental problems: Loose teeth 3.8 4.6 10.8 3.3 -0.8 1.6 -2.0
Emphysema/chronic bronchitis 1.5 1.7 4.7 -0.8 2.2 0.7 -1.1
Medication for pain relief, constipation, heartburn 3.5 6.0 21.0 -0.3 -4.6 -1.7 0.6
Neck or shoulder pain in last month 0.6 0.9 2.5 1.6 0.6 0.5 -0.6
Medication: Blood pressure 1.0 1.7 5.6 -0.5 2.4 0.3 0.9
Angina (self-reported) 1.7 2.2 5.9 -2.4 1.0 1.3 0.3
Migraine (self-reported) 0.6 0.7 1.6 0.7 0.1 0.9 -1.3
Medication: Ibuprofen 1.0 1.3 4.5 0.1 2.1 0.5 -0.6
Medication: Allopurinol 1.5 2.0 6.8 0.4 2.6 0.1 1.0
Medication: Omeprazole 1.4 1.7 6.7 -0.1 2.6 0.0 -0.0
Medication: Seretide 50 evohaler 2.7 3.1 10.6 0.1 3.3 0.9 -1.0
Mean time to correctly identify matches 0.2 0.4 1.2 -1.1 0.0 0.4 -0.4
Heart disease (mother) 0.8 0.9 3.1 0.1 1.8 0.7 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 0.9 0.7 0.9 0.7 0.3
Whole body fat mass 3.0 12.5 23.2 -2.4 4.8 -0.1 -4.6
Leg fat mass (right) 2.7 10.3 21.0 -1.6 4.1 1.0 -4.6
Arm predicted mass (right) 1.2 6.4 14.7 -2.2 -1.9 -1.5 -3.8
Pulse rate, automated reading 0.1 0.5 1.0 0.8 0.4 0.4 1.0
Alcohol intake frequency. 0.2 0.5 0.7 0.5 0.6 -0.7 -0.8
Comparative height size at age 10 3.8 21.1 44.2 -6.2 -1.0 -6.7 -0.6
Number of full sisters 0.5 0.6 1.0 1.0 0.8 -0.6 -0.5
Suffer from ‘nerves’ 0.5 0.7 1.4 -0.9 -0.6 -0.5 1.2
Overall health rating 0.7 1.6 2.5 0.1 1.2 1.6 -1.5
Chest pain or discomfort 0.9 1.3 2.6 0.0 1.1 1.6 -1.1
Had major operations 2.8 3.3 9.0 -1.3 -3.0 -0.3 1.5
Age at last live birth 1.2 1.7 5.3 -0.3 -0.8 -0.8 2.3
Family relationship satisfaction 1.4 1.8 5.9 -0.8 -2.4 0.6 -0.5
Leg pain on walking 1.9 2.3 6.1 2.5 0.6 1.7 0.1
Qualifications: NVQ or HND or HNC or equivalent 1.8 2.2 4.4 1.3 -0.1 2.1 -1.6
Commuting to job workplace: Car/motor vehicle 1.3 1.4 2.2 -1.3 1.5 -0.9 1.0
Illness, injury, bereavement, stress in last 2 years 0.9 1.2 3.8 0.2 0.2 1.9 -0.9
Medication: Aspirin 0.9 1.1 2.7 -0.2 1.6 1.2 -0.5
Supplements: Vitamin C 1.1 1.3 2.6 -1.4 0.6 -1.6 0.7
Knee pain experienced in last month 1.2 1.8 2.4 1.3 1.1 1.5 -1.4
Hypertension (Self-reported) 0.7 1.8 3.4 1.0 1.9 1.7 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 3.1 -1.1 1.2 0.3 1.8
Illnesses of father: Heart disease 0.6 0.8 2.7 -0.5 0.5 1.6 -0.4
Illnesses of siblings: Diabetes 0.5 0.7 2.6 -0.2 -0.1 -0.2 1.6
Smoking status: Previous 1.7 2.5 5.9 -0.2 0.8 1.9 -2.4
Forced expiratory volume in 1-second (FEV1), predicted 6.2 12.9 26.1 -4.2 -1.2 -5.1 2.5
Whole body fat-free mass 1.3 7.2 12.5 -2.6 -2.0 -2.3 -3.5
Leg fat-free mass (right) 1.2 6.3 17.5 -2.2 -0.1 -1.7 -4.2
Arm fat percentage (left) 3.6 14.5 31.1 -0.8 5.6 2.1 -4.7
Average weekly red wine intake 0.6 0.9 2.2 -1.5 -0.0 -0.8 -0.8
Handedness (chirality/laterality): Left-handed 0.8 1.0 3.1 1.7 0.5 -0.3 0.7
Mood swings 0.4 0.7 1.9 0.1 1.4 0.4 0.8
Loneliness, isolation 1.8 2.5 6.2 1.4 -0.5 2.5 -1.3
Long-standing illness, disability or infirmity 0.4 0.6 2.1 -0.1 1.4 0.4 0.1
Ever had bowel cancer screening 0.5 0.6 0.8 0.7 -0.7 0.8 -0.9
Diabetes diagnosed by doctor 1.2 2.0 5.2 -0.9 -0.2 -1.4 2.3
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 4.8 2.2 -0.1 0.8 -1.0
Friendships satisfaction 1.1 1.4 4.2 -0.1 -2.1 0.8 -0.7
Qualifications: nursing, teaching 0.7 1.1 2.3 1.0 -1.5 -0.6 0.9
Commuting to job workplace: Walk 0.4 0.4 1.2 -1.1 -0.4 -0.5 -0.4
Eye problems/disorders: Cataract 0.7 0.9 1.4 1.0 0.7 1.2 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.9 1.0 0.5 0.7 0.4
Medication for cholesterol 1.3 2.0 6.6 -1.0 0.5 -2.6 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.9 -0.5 1.4 -0.7 0.2
Back pain experienced in last month 2.8 4.1 10.1 -1.4 3.2 -2.0 0.4
Mineral and other dietary supplements 1.2 1.6 3.3 -0.2 -1.8 1.6 -0.7
Breast cancer (self-reported) 1.0 1.2 2.5 0.4 -0.5 -1.4 1.6
Asthma (self-reported) 3.7 7.3 9.9 2.8 2.5 3.1 -2.3
Osteoporosis (self-reported) 0.6 0.8 1.7 0.8 -0.8 1.3 0.3
Osteoarthritis (self-reported) 1.7 2.2 3.1 1.8 1.0 1.8 -1.3
Medication: Aspirin 0.9 1.2 2.3 -0.1 1.5 1.5 -0.7
Medication: Gliclazide 0.5 0.6 1.7 0.2 -0.2 -1.3 0.8
Illnesses of father: None of the above (group 1) 1.0 1.2 3.0 0.4 1.3 -1.7 0.2
Smoking status: Current 0.6 1.0 2.1 1.4 1.2 0.3 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.3 6.9 11.1 -1.7 -3.3 -3.2 1.9
Whole body water mass 1.2 7.1 12.7 -2.6 -2.1 -2.2 -3.6
Leg predicted mass (right) 1.2 6.3 17.8 -2.2 -0.1 -1.6 -4.2
Arm fat mass (left) 2.6 10.6 23.7 -1.4 4.0 0.8 -4.9
Number of self-reported non-cancer illnesses 2.4 4.2 8.0 1.6 2.1 2.8 -1.3
Average weekly champagne plus white wine intake 0.6 0.8 2.4 -1.5 0.4 -0.2 0.8
Miserableness 0.5 0.9 1.8 -1.1 -0.0 -0.6 1.3
Guilty feelings 0.5 0.7 1.4 0.1 -1.1 0.5 1.2
Wears glasses or contact lenses 2.4 2.7 4.0 -1.8 0.8 -2.0 1.8
Ever taken oral contraceptive pill 2.4 2.7 4.1 -1.9 0.2 -1.7 2.0
Hearing aid user 0.9 1.1 3.6 0.7 1.9 -0.5 -0.2
Mother’s age at death 0.6 0.8 2.5 -0.6 -0.3 -1.6 0.5
Financial situation satisfaction 1.7 2.2 5.1 -0.5 -2.2 1.0 -1.5
Tinnitus: Yes, now most or all of the time 1.5 1.7 4.2 -0.5 1.0 -2.0 1.1
Commuting to job workplace: Public transport 2.3 2.8 9.2 0.8 -3.0 0.9 0.6
Eye problems/disorders: Glaucoma 2.0 2.4 4.3 -1.0 2.1 -1.4 1.5
Medication: Blood pressure 1.2 2.3 6.3 1.3 1.1 2.5 -0.2
Pain type(s) experienced in last month: Hip pain 1.2 1.5 3.5 0.9 1.9 -0.1 -1.3
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.9 -0.0 0.9 0.3 -0.2
High cholesterol (Self-reported) 2.9 5.1 8.9 2.0 1.5 3.0 -2.2
Medication: Bendroflumethiazide 0.4 0.7 1.7 0.8 1.3 0.5 0.1
Medication: Paracetamol 1.8 2.8 5.8 -0.1 2.4 1.7 -1.6
Medication: Lisinopril 0.6 0.7 1.4 1.2 0.8 0.8 0.6
Medication: Atorvastatin 1.7 2.1 7.6 0.1 0.4 2.8 -0.7
Illnesses of father: High blood pressure 1.1 1.3 2.9 -0.5 -1.7 1.4 -0.1
Alcohol drinker status: Never 0.8 1.0 2.9 -0.9 0.3 -1.7 0.4
Ever smoked 1.3 2.2 6.8 0.5 -0.6 1.3 -2.6
Basal metabolic rate 1.3 7.1 15.7 -2.7 -0.9 -2.1 -4.0
Leg fat percentage (left) 4.4 16.0 29.2 -0.4 5.4 3.0 -5.1
Arm fat-free mass (left) 1.2 6.2 16.1 -2.1 -1.6 -1.4 -4.0
Number of operations (self-reported) 1.5 2.2 6.9 -0.0 -2.6 1.3 0.2
Average weekly beer plus cider intake 0.7 1.0 1.6 1.3 -1.0 -0.6 1.0
Irritability 1.5 2.6 7.7 1.4 2.8 0.2 0.8
Risk taking 1.9 2.8 3.4 1.8 -1.3 1.8 -1.7
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.1 -0.6 0.4 0.9 -1.1
Fractured/broken bones in last 5 years 1.3 1.7 4.8 -2.2 0.1 -1.2 -0.7
Age started oral contraceptive pill 0.9 1.1 4.0 -2.0 -0.5 -0.2 -0.5
Diastolic blood pressure, automated reading 0.6 2.0 5.3 -0.1 1.3 2.3 -1.0
Ever depressed for a whole week 2.2 2.7 4.5 -1.9 -2.1 -0.7 1.5
Unable to work because of sickness or disability 2.2 2.9 6.8 -0.2 0.4 2.6 -2.2
Commuting to job workplace: Cycle 2.5 3.0 4.8 -0.3 -2.2 -1.5 2.2
Myopia 1.0 1.4 2.1 1.1 -1.4 1.3 0.8
Vascular/heart problems diagnosed by doctor 0.8 2.3 6.5 -0.5 -2.5 -1.5 -0.5
Cholesterol lowering medication 4.6 6.7 14.8 2.7 0.6 3.9 -2.2
Medication: Omeprazole (e.g. Zanprol) 1.6 1.9 7.3 -0.5 2.7 0.2 -0.2
Pain experienced in last month 1.1 1.9 5.0 -1.6 -2.2 -0.1 0.1
Supplements: Calcium 0.5 0.6 0.8 -0.9 -0.2 -0.8 0.8
Basal cell carcinoma (self-reported) 0.6 0.8 1.2 0.7 -1.0 -1.1 0.6
Heart attack/myocardial infarction (self-reported) 2.5 3.2 9.6 -1.4 3.1 0.7 -0.8
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 3.2 0.2 1.8 -0.8 -0.4
Heart disease (siblings) 0.8 1.0 1.7 1.3 0.8 1.2 -0.3
Alcohol drinker status: Previous 0.7 0.8 1.6 0.5 1.2 -0.0 -1.2
Pack years of smoking 0.9 1.3 4.0 0.5 -0.3 2.0 -0.9
Impedance of whole body 2.3 11.5 17.2 -3.0 3.2 -4.2 3.1
Leg fat mass (left) 2.9 11.5 24.3 -1.3 4.3 1.3 -4.9
Arm predicted mass (left) 1.2 6.0 15.8 -2.1 -1.7 -1.1 -4.0