Hub : Genes

PPARD

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.3710	0.1040	0.00011	0.062	NA	0.110	NA	0.134	0.00670	NA	0.00039	NA	9.3e-05
2	METSIM	Adipose	0.0391	0.0198	0.00730	0.000	0.003	0.013	0.006	0.002	0.38000	0.1100	0.00390	0.035	1.6e-01
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0700	0.0370	0.00220	0.056	0.036	0.014	NA	0.040	0.00037	0.0036	0.05100	NA	2.5e-03
4	TCGA	Testicular Germ Cell Tumors	0.1200	0.0620	0.00210	0.100	0.020	0.011	NA	0.055	0.00022	0.0630	0.13000	NA	5.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.7	1.7	-1.3	0.9	0.5	-0.6
Bipolar Disorder or Schizophrenia	0.2	0.5	0.8	-0.9	-0.4	-0.8	0.6
Depressed Affect (Nagel 2018)	0.3	0.6	1.0	-0.7	1.0	1.0	0.2
Depression (Nagel 2018)	0.6	0.9	1.9	-1.4	-0.3	-0.4	1.2
Intelligence (Savage-Jansen 2018)	0.7	2.3	8.1	2.9	0.7	0.4	0.6
Neuroticism (Nagel 2018)	1.1	2.6	8.6	-1.1	0.7	-0.4	2.9
Schizophrenia (2018)	0.5	1.1	2.0	-0.1	-1.1	-1.4	1.2
Schizophrenia vs Biploar Disorder	0.6	0.8	1.3	-0.0	-1.2	-0.7	1.1
Worry (Nagel 2018)	1.8	3.8	10.2	-1.8	-0.7	-1.1	3.2
Alzheimer’s Disease (in mother)	1.6	1.8	5.6	0.5	-0.6	-1.1	2.4
Alzheimer’s Disease (in father)	0.7	0.8	1.5	0.4	-1.2	-0.5	1.1
Alzheimer’s Disease (including proxy)	1.5	2.2	5.5	0.7	-1.6	-0.5	2.3
Crohns Disease (2017)	0.7	1.4	3.9	2.0	-0.5	1.2	0.3
Irritable Bowel Disease (IBD)	0.7	1.8	5.6	1.0	0.6	-0.1	2.4
Ulcerative Colitis (UC)	2.1	3.9	11.5	-0.3	1.4	-1.4	3.4
Major Depression (MDD)	0.5	0.6	1.3	0.2	-0.4	1.1	-1.0
Reaction Time	0.4	0.7	1.6	-1.3	0.2	1.0	-0.4
Verbal and Numeric Reasoning (VNR)	0.5	1.1	1.8	1.3	-0.3	-0.8	1.3
Breast Cancer	1.0	2.4	5.1	-2.3	0.7	-0.9	1.8
Ovarian Cancer	0.6	0.8	2.0	-0.2	0.3	-1.4	0.9
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.6	2.3	6.6	0.1	-1.4	-0.7	2.6
Bipolar Disorder (2011)	2.7	2.6	7.3	-2.7	1.4	-1.1	-0.2
Body Mass Index (BMI) (2010)	1.4	2.0	7.2	-0.2	-0.1	0.8	-2.7
Coronary Artery Disease (CAD)	1.4	1.6	3.1	0.9	1.6	1.8	-0.4
Crohns Disease (2012)	0.6	0.9	2.6	1.6	-0.4	0.7	0.6
Mean Putamen Volume	0.6	0.7	2.2	0.0	-1.5	0.3	-0.7
Fasting Glucose	0.4	0.5	1.5	1.2	0.2	0.7	0.0
HbA1C	1.4	1.5	3.0	-0.8	1.1	-1.2	1.7
HDL Cholesterol	1.3	2.2	3.7	1.8	-1.2	1.9	-0.8
LDL Cholesterol	1.9	3.1	5.0	2.2	-0.1	1.8	-2.0
Lupus	4.2	6.3	12.5	1.6	0.7	3.1	-3.5
Neuroticism (2016)	0.7	1.0	2.1	-0.3	-0.8	1.5	1.1
Primary Biliary Cirrhosis	2.8	4.0	9.0	2.2	3.0	0.5	-1.4
Rheumatoid Arthritis	0.7	0.9	2.4	-1.6	0.9	-0.4	-0.5
Schizophrenia (2014)	0.1	0.3	0.7	0.0	-0.9	-0.5	0.3
Triglycerides	1.1	1.8	3.2	1.2	1.5	0.5	-1.8
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.8	0.9	1.4	0.2	0.8
Ulcerative Colitis	2.0	3.0	7.4	0.8	2.7	-0.8	1.8
Blood Eosinophil Count	3.3	25.1	70.5	-1.8	8.4	-2.9	4.3
Blood Platelet Count	2.1	24.3	85.2	0.2	0.4	-3.5	9.2
Blood Red Count	0.5	4.8	14.0	0.8	-3.7	2.1	-0.0
Blood White Count	3.4	24.9	42.6	-3.3	-5.0	-4.6	6.5
Heel T-Score	1.2	9.3	27.2	1.5	-1.8	-2.1	5.2
BMI	2.7	15.7	26.8	0.9	3.9	4.5	-5.2
Height	5.0	96.6	225.0	-12.5	-2.2	-15.0	-0.2
Waist Hip Ratio (WHR)	0.5	2.3	7.0	0.8	1.0	0.9	2.6
Systolic Blood Pressure	0.9	4.4	8.3	-2.6	-1.5	0.7	2.9
Smoking Status	1.9	4.5	5.6	2.3	2.4	1.5	-2.1
Allergy or Eczema	0.5	1.3	4.5	0.8	2.1	-0.2	-0.0
Cardiovascular Disease	1.0	3.4	8.4	1.0	2.9	1.9	-0.5
Hypothyroidism (self reported)	1.5	3.4	7.6	-2.8	2.2	-0.9	-0.0
Respiratory disease	3.1	6.9	8.0	2.8	2.8	2.8	-2.1
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.4	0.1	0.8	-0.6	1.5
Lung FEV1/FVC ratio	1.7	8.9	16.2	-2.7	-1.4	-4.0	3.2
Lung FVC	1.9	9.8	32.0	-1.5	-5.7	-1.1	1.9
Neuroticism	0.5	1.1	3.1	-0.8	1.0	0.1	1.8
Chronotype (morning person)	0.8	1.9	5.8	-1.1	-2.4	-0.1	-0.7
Hair Pigment	0.4	12.7	24.3	-4.9	-0.9	-2.9	4.2
Tanning	0.1	1.5	3.7	1.9	1.1	-0.4	-1.0
Hand grip strength (left)	2.6	6.9	15.4	-1.9	-2.5	-3.9	1.5
Number of treatments/medications taken	1.9	3.4	8.8	1.1	3.0	1.8	-0.6
Average weekly spirits intake	2.3	2.8	8.7	0.0	2.9	1.5	-0.7
Sensitivity / hurt feelings	2.4	4.2	12.2	-1.1	0.6	-1.7	3.5
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.3	-0.7	-1.8	0.1	0.5
Hearing difficulty/problems: Yes	1.1	1.6	2.9	-1.0	1.7	-1.3	1.0
Relative age of first facial hair	1.4	2.8	8.5	-0.5	0.3	-2.9	1.5
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.2	0.4	1.2	-0.3	-1.5
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.9	0.6	1.4	0.7	-0.1
Ever had hysterectomy (womb removed)	1.0	1.1	1.6	1.1	0.8	1.3	-0.9
Systolic blood pressure, automated reading	0.7	2.0	5.4	-2.3	0.2	0.7	1.4
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.0	-1.7	-1.0	-0.8	0.2
Angina	1.5	2.0	5.0	-2.2	1.2	1.2	0.4
Medication for hormone replacement therapy	0.4	0.5	1.0	-0.2	-0.9	-0.1	1.0
Vitamin and mineral supplements	0.6	0.8	1.8	-0.9	-1.3	0.4	-0.5
Supplements: Zinc	0.4	0.5	0.9	0.9	-0.7	-0.7	0.1
Medication: Co-codamol	1.3	1.5	2.7	0.5	-0.9	1.5	-1.6
Medication: Metformin	0.2	0.3	0.4	0.6	0.3	-0.6	0.6
Diabetes (father)	0.5	0.6	1.8	-1.3	0.5	-0.4	-0.3
Diabetes (mother)	0.9	1.1	2.2	0.1	-1.4	-1.5	0.6
Severe depression (siblings)	0.5	0.5	0.8	-0.9	-0.8	-0.2	0.8
Pack years adult smoking proportion	1.0	1.5	4.3	0.1	-0.9	2.1	-0.8
Impedance of leg (right)	2.1	9.9	15.5	-3.0	1.3	-3.7	3.9
Leg fat-free mass (left)	1.2	6.4	17.1	-2.4	-0.3	-1.6	-4.1
Trunk fat percentage	4.8	19.1	52.0	-2.3	7.2	-0.1	-4.4
Hand grip strength (right)	2.4	6.4	14.4	-2.0	-1.9	-3.8	1.9
Townsend deprivation index at recruitment	1.9	2.7	3.9	1.8	-1.1	1.6	-2.0
Current tobacco smoking	0.5	0.8	1.8	1.4	0.9	0.4	-0.6
Average weekly fortified wine intake	0.7	0.8	2.2	1.5	0.6	0.1	-0.7
Maternal smoking around birth	1.9	2.7	7.0	1.5	0.6	2.6	-1.1
Fed-up feelings	0.4	0.8	1.8	-0.7	1.3	1.0	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.8	-0.8	0.9	-0.7	1.3
Relative age voice broke	1.4	2.1	3.8	-1.9	-0.2	-1.7	1.3
Taking other prescription medications	0.5	0.8	2.3	0.0	1.5	0.1	0.8
Age when periods started (menarche)	0.8	1.9	2.7	1.1	1.4	-1.3	1.6
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	6.5	-0.3	-0.6	-1.0	2.5
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	11.1	-0.3	0.3	-1.4	3.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.3	0.4	-1.1	0.3	-0.8
Qualifications: CSEs or equivalent	1.6	2.1	4.9	0.2	0.5	2.2	-1.7
Serious illness, injury or assault to yourself	0.7	0.8	2.8	-0.2	1.7	-0.3	0.6
High blood pressure	0.5	1.4	2.5	0.8	1.6	1.3	0.9
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.0	0.6	1.0	1.0	-0.7
Multivitamins +/- minerals	0.3	0.4	0.9	0.9	0.1	0.8	-0.3
Stomach or abdominal pain in last month	0.4	0.4	1.3	-0.3	-0.3	0.5	-1.1
Supplements: Glucosamine	0.7	1.0	2.9	1.7	0.6	-0.7	-0.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.1	-0.4	-1.0	0.2	0.4
Medication: Atenolol	1.3	1.7	4.0	-0.5	2.0	1.3	-0.9
Medication: Levothyroxine sodium	0.6	1.1	3.2	-1.8	1.0	-0.2	0.3
Sitting height	1.5	10.5	25.9	-5.1	-0.9	-3.0	-2.5
Chronic bronchitis/emphysema (father)	0.5	0.5	1.4	0.3	0.4	0.7	1.2
High blood pressure (mother)	1.9	2.7	6.4	1.1	-2.5	1.6	-0.8
Body mass index (BMI)	2.7	11.5	22.5	0.7	3.3	3.5	-4.7
Impedance of leg (left)	1.7	8.4	11.2	-2.6	2.2	-3.3	3.3
Leg predicted mass (left)	1.2	6.3	17.0	-2.3	-0.4	-1.6	-4.1
Trunk fat mass	3.6	15.6	32.5	-2.8	5.7	-0.8	-4.6
Waist circumference	1.9	7.0	15.7	-0.8	2.9	1.7	-4.0
Number of incorrect matches in round	1.6	2.6	4.1	-2.0	-0.7	-2.0	1.4
Past tobacco smoking	1.9	3.5	8.1	-0.5	-1.1	-2.1	2.8
Alcohol usually taken with meals	0.8	1.4	2.9	-1.7	-1.1	-1.1	0.5
Nervous feelings	0.5	1.0	1.9	-0.6	-1.3	0.2	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.8	0.2	-0.1	0.9	-0.2
Hearing difficulty/problems with background noise	1.1	1.8	4.4	-2.1	-0.1	-1.6	0.7
Hair/balding pattern: Pattern 2	1.3	1.6	3.5	1.4	1.9	0.6	-0.8
Had menopause	0.2	0.2	0.5	-0.3	0.6	-0.1	-0.7
Had other major operations	0.6	0.7	2.6	-0.3	-1.6	0.4	0.1
Forced vital capacity (FVC)	4.1	15.6	22.4	-4.2	-4.7	-4.6	0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	13.0	-0.6	-0.4	-2.0	3.6
Ever unenthusiastic/disinterested for a whole week	4.6	5.6	10.6	-3.3	-3.2	-0.7	1.1
Qualifications: None of the above	0.8	1.8	4.0	-1.0	2.0	0.6	-1.3
Financial difficulties in last 2 years	0.4	0.5	0.9	0.9	0.2	0.5	-0.9
Mouth/teeth dental problems	0.8	1.2	3.2	-1.8	-0.5	-1.1	-0.4
Heart attack	2.4	3.1	8.9	-1.5	3.0	0.7	-0.7
Allergy	1.3	2.9	5.0	-1.3	-2.2	-1.8	1.4
Pain all over the body in last month	0.5	0.6	1.6	0.1	0.7	0.4	1.3
Diabetes (self-reported)	0.4	0.6	1.6	-0.2	0.6	-0.5	1.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.5	-0.0	-0.7	0.6	0.2
Medication: Ramipril	1.8	2.3	4.7	2.2	1.3	1.6	0.5
Medication: Simvastatin	1.5	2.2	4.4	2.1	1.4	1.4	-0.5
Fluid intelligence score	0.5	1.0	1.6	0.5	-0.9	-1.3	1.1
Illnesses of siblings	0.5	0.8	1.4	-1.0	-0.8	-0.2	-1.2
Neuroticism score	0.3	0.7	2.4	-0.6	0.1	-0.1	1.5
Weight	1.8	9.0	21.9	-2.8	2.2	-1.1	-4.7
Impedance of arm (right)	2.2	10.5	18.1	-2.3	3.2	-4.3	2.9
Arm fat percentage (right)	3.3	13.1	29.3	-0.6	5.4	2.1	-4.3
Trunk fat-free mass	1.5	8.5	11.4	-2.8	-3.4	-2.9	-2.6
Hip circumference	1.9	8.3	23.5	-2.1	2.2	-0.4	-4.8
Time employed in main current job	1.7	2.0	5.3	-2.3	1.3	-0.0	-0.9
Alcohol intake versus 10 years previously	1.9	2.8	4.5	-1.6	-0.4	-2.1	2.0
Father’s age at death	0.4	0.6	1.2	-1.1	-0.4	-0.9	0.4
Worrier / anxious feelings	4.5	8.6	16.3	-2.7	0.7	-3.2	4.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	0.8	-0.9	0.7	-0.7	0.7
Falls in the last year	1.4	1.9	6.8	0.7	0.0	0.4	-2.6
Hair/balding pattern: Pattern 3	0.6	0.9	3.0	0.2	-1.7	-0.5	0.2
Number of live births	2.5	3.6	5.9	1.7	0.8	2.3	-2.4
Forced expiratory volume in 1-second (FEV1)	5.2	17.7	25.7	-4.2	-5.0	-5.1	1.6
Pulse rate	0.2	0.4	1.1	0.2	0.6	1.1	0.3
Happiness	1.0	1.2	2.1	-1.1	-1.4	-1.0	0.7
Noisy workplace	1.0	1.2	3.5	1.9	0.4	-0.0	1.1
Qualifications: A levels/AS levels or equivalent	1.1	2.5	5.8	0.5	-1.2	-1.6	2.4
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	4.2	0.4	-1.3	-2.1	1.6
Mouth/teeth dental problems: Dentures	0.4	0.7	1.9	0.8	0.1	1.4	-0.3
Asthma	3.6	7.0	9.9	2.8	2.3	3.2	-2.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	3.1	0.0	1.8	0.5	-0.6
Medication: Cholesterol lowering	1.2	1.9	5.7	0.4	2.4	1.2	-0.6
Depression (self-reported)	1.1	1.3	2.6	-1.6	-1.4	-0.5	0.7
Medication: Lansoprazole	0.3	0.3	0.8	-0.9	0.4	-0.1	0.5
Prospective memory result	0.7	0.8	2.4	-0.6	1.6	0.1	0.6
Lung cancer (father)	1.6	1.9	3.3	-0.8	1.5	-1.2	1.8
Illnesses of mother	1.5	1.8	3.5	-1.9	-0.9	-1.7	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	6.0	19.1	29.8	-4.1	-5.0	-5.5	2.2
Pulse wave Arterial Stiffness index	0.8	0.9	1.4	0.5	1.1	-0.8	-1.2
Impedance of arm (left)	2.6	11.9	20.4	-3.0	3.4	-4.5	2.5
Arm fat mass (right)	2.6	10.9	22.9	-1.3	4.3	0.9	-4.8
Trunk predicted mass	1.5	8.4	11.5	-2.8	-3.4	-2.8	-2.5
Standing height	4.2	41.4	100.0	-7.8	-2.1	-10.0	-0.3
Length of working week for main job	0.9	1.0	1.8	-0.5	-1.1	1.4	-0.7
Exposure to tobacco smoke at home	5.1	5.7	10.0	2.0	-0.8	2.9	-3.2
Breastfed as a baby	1.6	2.0	5.4	-1.2	1.0	-2.3	0.1
Tense / ‘highly strung’	0.4	0.7	1.5	-1.2	0.0	-0.5	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.2	7.8	-1.0	-2.8	0.0	0.2
Hair/balding pattern: Pattern 4	1.8	4.4	11.4	-1.6	-1.9	-0.3	3.4
Birth weight of first child	2.6	4.6	11.9	-1.0	-3.4	-1.8	1.6
Peak expiratory flow (PEF)	4.1	9.6	12.5	-3.3	-3.0	-3.5	2.4
Pulse wave reflection index	0.4	0.5	1.1	1.0	0.1	-0.1	-1.1
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.4	-0.4	-0.6	-0.3	0.2
Loud music exposure frequency	0.0	0.0	0.1	0.0	0.1	-0.1	-0.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.1	-0.1	-1.3	-0.7	1.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.3	1.5	0.1	0.0	0.6
Blood clot in the leg (DVT)	0.9	1.2	3.9	0.1	2.0	-0.9	-0.4
Medication: Paracetamol	1.2	2.0	5.5	0.2	2.4	1.1	-1.1
Headache pain in last month	0.2	0.3	0.8	0.6	0.9	0.3	-0.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	4.0	0.1	-2.0	-0.4	-0.6
Glaucoma (self-reported)	0.9	1.1	2.6	-1.1	1.6	-0.7	0.4
Gout (self-reported)	1.6	2.3	8.6	0.1	2.9	0.4	0.6
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	6.8	-2.6	1.8	-1.1	0.3
Medication: Amlodipine	0.8	1.1	2.8	-0.0	1.2	-0.3	1.7
Medication: Ventolin 100micrograms inhaler	0.8	1.1	2.2	1.5	1.2	0.7	0.4
Birth weight	0.8	1.7	3.6	-0.6	-1.2	-1.9	1.2
Chronic bronchitis/emphysema (mother)	2.9	3.4	7.6	2.0	2.8	1.3	-0.6
High blood pressure (siblings)	0.1	0.1	0.2	0.5	0.4	0.2	0.3
Forced vital capacity (FVC), Best measure	4.3	15.7	23.4	-3.9	-4.7	-4.8	1.3
Body fat percentage	4.4	17.3	45.0	-1.9	6.7	0.9	-4.5
Leg fat percentage (right)	3.4	12.5	24.1	-1.0	4.9	2.4	-4.4
Arm fat-free mass (right)	1.3	6.4	14.5	-2.4	-1.8	-1.6	-3.8
Exposure to tobacco smoke outside home	0.5	0.6	1.4	0.2	1.2	-0.8	-0.6
Comparative body size at age 10	3.1	8.4	16.5	1.6	-1.6	4.1	-3.5
Number of full brothers	0.5	0.7	1.4	1.2	0.9	0.7	-0.3
Worry too long after embarrassment	1.4	2.4	8.6	-0.2	0.6	-0.8	2.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	-0.4	-1.0	0.1	0.7
Wheeze or whistling in the chest in last year	2.2	3.9	8.4	1.6	2.9	1.5	-1.5
Number of children fathered	1.1	1.3	3.3	-1.2	1.8	-0.6	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.8	0.7	0.6	-0.1	-0.9
Age at first live birth	1.9	3.4	10.0	-0.5	-1.0	-1.6	3.2
Pulse wave peak to peak time	0.7	0.8	1.2	-0.9	-1.1	0.1	1.1
Health satisfaction	1.0	1.2	2.9	0.8	0.5	1.1	-1.7
Shortness of breath walking on level ground	1.8	2.1	3.3	-0.4	1.8	1.6	-1.5
Qualifications: College or University degree	0.8	2.5	6.0	1.4	-0.5	-2.4	1.3
Eye problems/disorders: None of the above	0.4	0.5	1.8	0.2	-1.4	0.0	-0.1
Mouth/teeth dental problems: Loose teeth	3.8	4.6	10.8	3.3	-0.8	1.6	-2.0
Emphysema/chronic bronchitis	1.5	1.7	4.7	-0.8	2.2	0.7	-1.1
Medication for pain relief, constipation, heartburn	3.5	6.0	21.0	-0.3	-4.6	-1.7	0.6
Neck or shoulder pain in last month	0.6	0.9	2.5	1.6	0.6	0.5	-0.6
Medication: Blood pressure	1.0	1.7	5.6	-0.5	2.4	0.3	0.9
Angina (self-reported)	1.7	2.2	5.9	-2.4	1.0	1.3	0.3
Migraine (self-reported)	0.6	0.7	1.6	0.7	0.1	0.9	-1.3
Medication: Ibuprofen	1.0	1.3	4.5	0.1	2.1	0.5	-0.6
Medication: Allopurinol	1.5	2.0	6.8	0.4	2.6	0.1	1.0
Medication: Omeprazole	1.4	1.7	6.7	-0.1	2.6	0.0	-0.0
Medication: Seretide 50 evohaler	2.7	3.1	10.6	0.1	3.3	0.9	-1.0
Mean time to correctly identify matches	0.2	0.4	1.2	-1.1	0.0	0.4	-0.4
Heart disease (mother)	0.8	0.9	3.1	0.1	1.8	0.7	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.9	0.7	0.9	0.7	0.3
Whole body fat mass	3.0	12.5	23.2	-2.4	4.8	-0.1	-4.6
Leg fat mass (right)	2.7	10.3	21.0	-1.6	4.1	1.0	-4.6
Arm predicted mass (right)	1.2	6.4	14.7	-2.2	-1.9	-1.5	-3.8
Pulse rate, automated reading	0.1	0.5	1.0	0.8	0.4	0.4	1.0
Alcohol intake frequency.	0.2	0.5	0.7	0.5	0.6	-0.7	-0.8
Comparative height size at age 10	3.8	21.1	44.2	-6.2	-1.0	-6.7	-0.6
Number of full sisters	0.5	0.6	1.0	1.0	0.8	-0.6	-0.5
Suffer from ‘nerves’	0.5	0.7	1.4	-0.9	-0.6	-0.5	1.2
Overall health rating	0.7	1.6	2.5	0.1	1.2	1.6	-1.5
Chest pain or discomfort	0.9	1.3	2.6	0.0	1.1	1.6	-1.1
Had major operations	2.8	3.3	9.0	-1.3	-3.0	-0.3	1.5
Age at last live birth	1.2	1.7	5.3	-0.3	-0.8	-0.8	2.3
Family relationship satisfaction	1.4	1.8	5.9	-0.8	-2.4	0.6	-0.5
Leg pain on walking	1.9	2.3	6.1	2.5	0.6	1.7	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	4.4	1.3	-0.1	2.1	-1.6
Commuting to job workplace: Car/motor vehicle	1.3	1.4	2.2	-1.3	1.5	-0.9	1.0
Illness, injury, bereavement, stress in last 2 years	0.9	1.2	3.8	0.2	0.2	1.9	-0.9
Medication: Aspirin	0.9	1.1	2.7	-0.2	1.6	1.2	-0.5
Supplements: Vitamin C	1.1	1.3	2.6	-1.4	0.6	-1.6	0.7
Knee pain experienced in last month	1.2	1.8	2.4	1.3	1.1	1.5	-1.4
Hypertension (Self-reported)	0.7	1.8	3.4	1.0	1.9	1.7	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.1	-1.1	1.2	0.3	1.8
Illnesses of father: Heart disease	0.6	0.8	2.7	-0.5	0.5	1.6	-0.4
Illnesses of siblings: Diabetes	0.5	0.7	2.6	-0.2	-0.1	-0.2	1.6
Smoking status: Previous	1.7	2.5	5.9	-0.2	0.8	1.9	-2.4
Forced expiratory volume in 1-second (FEV1), predicted	6.2	12.9	26.1	-4.2	-1.2	-5.1	2.5
Whole body fat-free mass	1.3	7.2	12.5	-2.6	-2.0	-2.3	-3.5
Leg fat-free mass (right)	1.2	6.3	17.5	-2.2	-0.1	-1.7	-4.2
Arm fat percentage (left)	3.6	14.5	31.1	-0.8	5.6	2.1	-4.7
Average weekly red wine intake	0.6	0.9	2.2	-1.5	-0.0	-0.8	-0.8
Handedness (chirality/laterality): Left-handed	0.8	1.0	3.1	1.7	0.5	-0.3	0.7
Mood swings	0.4	0.7	1.9	0.1	1.4	0.4	0.8
Loneliness, isolation	1.8	2.5	6.2	1.4	-0.5	2.5	-1.3
Long-standing illness, disability or infirmity	0.4	0.6	2.1	-0.1	1.4	0.4	0.1
Ever had bowel cancer screening	0.5	0.6	0.8	0.7	-0.7	0.8	-0.9
Diabetes diagnosed by doctor	1.2	2.0	5.2	-0.9	-0.2	-1.4	2.3
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	4.8	2.2	-0.1	0.8	-1.0
Friendships satisfaction	1.1	1.4	4.2	-0.1	-2.1	0.8	-0.7
Qualifications: nursing, teaching	0.7	1.1	2.3	1.0	-1.5	-0.6	0.9
Commuting to job workplace: Walk	0.4	0.4	1.2	-1.1	-0.4	-0.5	-0.4
Eye problems/disorders: Cataract	0.7	0.9	1.4	1.0	0.7	1.2	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.9	1.0	0.5	0.7	0.4
Medication for cholesterol	1.3	2.0	6.6	-1.0	0.5	-2.6	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.9	-0.5	1.4	-0.7	0.2
Back pain experienced in last month	2.8	4.1	10.1	-1.4	3.2	-2.0	0.4
Mineral and other dietary supplements	1.2	1.6	3.3	-0.2	-1.8	1.6	-0.7
Breast cancer (self-reported)	1.0	1.2	2.5	0.4	-0.5	-1.4	1.6
Asthma (self-reported)	3.7	7.3	9.9	2.8	2.5	3.1	-2.3
Osteoporosis (self-reported)	0.6	0.8	1.7	0.8	-0.8	1.3	0.3
Osteoarthritis (self-reported)	1.7	2.2	3.1	1.8	1.0	1.8	-1.3
Medication: Aspirin	0.9	1.2	2.3	-0.1	1.5	1.5	-0.7
Medication: Gliclazide	0.5	0.6	1.7	0.2	-0.2	-1.3	0.8
Illnesses of father: None of the above (group 1)	1.0	1.2	3.0	0.4	1.3	-1.7	0.2
Smoking status: Current	0.6	1.0	2.1	1.4	1.2	0.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.3	6.9	11.1	-1.7	-3.3	-3.2	1.9
Whole body water mass	1.2	7.1	12.7	-2.6	-2.1	-2.2	-3.6
Leg predicted mass (right)	1.2	6.3	17.8	-2.2	-0.1	-1.6	-4.2
Arm fat mass (left)	2.6	10.6	23.7	-1.4	4.0	0.8	-4.9
Number of self-reported non-cancer illnesses	2.4	4.2	8.0	1.6	2.1	2.8	-1.3
Average weekly champagne plus white wine intake	0.6	0.8	2.4	-1.5	0.4	-0.2	0.8
Miserableness	0.5	0.9	1.8	-1.1	-0.0	-0.6	1.3
Guilty feelings	0.5	0.7	1.4	0.1	-1.1	0.5	1.2
Wears glasses or contact lenses	2.4	2.7	4.0	-1.8	0.8	-2.0	1.8
Ever taken oral contraceptive pill	2.4	2.7	4.1	-1.9	0.2	-1.7	2.0
Hearing aid user	0.9	1.1	3.6	0.7	1.9	-0.5	-0.2
Mother’s age at death	0.6	0.8	2.5	-0.6	-0.3	-1.6	0.5
Financial situation satisfaction	1.7	2.2	5.1	-0.5	-2.2	1.0	-1.5
Tinnitus: Yes, now most or all of the time	1.5	1.7	4.2	-0.5	1.0	-2.0	1.1
Commuting to job workplace: Public transport	2.3	2.8	9.2	0.8	-3.0	0.9	0.6
Eye problems/disorders: Glaucoma	2.0	2.4	4.3	-1.0	2.1	-1.4	1.5
Medication: Blood pressure	1.2	2.3	6.3	1.3	1.1	2.5	-0.2
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.5	0.9	1.9	-0.1	-1.3
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.9	-0.0	0.9	0.3	-0.2
High cholesterol (Self-reported)	2.9	5.1	8.9	2.0	1.5	3.0	-2.2
Medication: Bendroflumethiazide	0.4	0.7	1.7	0.8	1.3	0.5	0.1
Medication: Paracetamol	1.8	2.8	5.8	-0.1	2.4	1.7	-1.6
Medication: Lisinopril	0.6	0.7	1.4	1.2	0.8	0.8	0.6
Medication: Atorvastatin	1.7	2.1	7.6	0.1	0.4	2.8	-0.7
Illnesses of father: High blood pressure	1.1	1.3	2.9	-0.5	-1.7	1.4	-0.1
Alcohol drinker status: Never	0.8	1.0	2.9	-0.9	0.3	-1.7	0.4
Ever smoked	1.3	2.2	6.8	0.5	-0.6	1.3	-2.6
Basal metabolic rate	1.3	7.1	15.7	-2.7	-0.9	-2.1	-4.0
Leg fat percentage (left)	4.4	16.0	29.2	-0.4	5.4	3.0	-5.1
Arm fat-free mass (left)	1.2	6.2	16.1	-2.1	-1.6	-1.4	-4.0
Number of operations (self-reported)	1.5	2.2	6.9	-0.0	-2.6	1.3	0.2
Average weekly beer plus cider intake	0.7	1.0	1.6	1.3	-1.0	-0.6	1.0
Irritability	1.5	2.6	7.7	1.4	2.8	0.2	0.8
Risk taking	1.9	2.8	3.4	1.8	-1.3	1.8	-1.7
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.1	-0.6	0.4	0.9	-1.1
Fractured/broken bones in last 5 years	1.3	1.7	4.8	-2.2	0.1	-1.2	-0.7
Age started oral contraceptive pill	0.9	1.1	4.0	-2.0	-0.5	-0.2	-0.5
Diastolic blood pressure, automated reading	0.6	2.0	5.3	-0.1	1.3	2.3	-1.0
Ever depressed for a whole week	2.2	2.7	4.5	-1.9	-2.1	-0.7	1.5
Unable to work because of sickness or disability	2.2	2.9	6.8	-0.2	0.4	2.6	-2.2
Commuting to job workplace: Cycle	2.5	3.0	4.8	-0.3	-2.2	-1.5	2.2
Myopia	1.0	1.4	2.1	1.1	-1.4	1.3	0.8
Vascular/heart problems diagnosed by doctor	0.8	2.3	6.5	-0.5	-2.5	-1.5	-0.5
Cholesterol lowering medication	4.6	6.7	14.8	2.7	0.6	3.9	-2.2
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	7.3	-0.5	2.7	0.2	-0.2
Pain experienced in last month	1.1	1.9	5.0	-1.6	-2.2	-0.1	0.1
Supplements: Calcium	0.5	0.6	0.8	-0.9	-0.2	-0.8	0.8
Basal cell carcinoma (self-reported)	0.6	0.8	1.2	0.7	-1.0	-1.1	0.6
Heart attack/myocardial infarction (self-reported)	2.5	3.2	9.6	-1.4	3.1	0.7	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	3.2	0.2	1.8	-0.8	-0.4
Heart disease (siblings)	0.8	1.0	1.7	1.3	0.8	1.2	-0.3
Alcohol drinker status: Previous	0.7	0.8	1.6	0.5	1.2	-0.0	-1.2
Pack years of smoking	0.9	1.3	4.0	0.5	-0.3	2.0	-0.9
Impedance of whole body	2.3	11.5	17.2	-3.0	3.2	-4.2	3.1
Leg fat mass (left)	2.9	11.5	24.3	-1.3	4.3	1.3	-4.9
Arm predicted mass (left)	1.2	6.0	15.8	-2.1	-1.7	-1.1	-4.0