Best TWAS P=3.37e-18 · Best GWAS P=4.39e-107 conditioned to 1.4e-64
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MPP7 | 0.07 | 0.04 | enet | 23 | 0.05 | 2.3e-06 | 7.01 | -5.2 | 2.3e-07 | 0.06 | 0.59 | 0.02 | FALSE |
| 2 | GTEx | Artery Aorta | ZNF438 | 0.12 | 0.00 | enet | 10 | 0.03 | 1.3e-02 | -7.39 | -6.7 | 2.3e-11 | -0.16 | 0.22 | 0.05 | FALSE |
| 3 | GTEx | Artery Tibial | WAC | 0.10 | 0.00 | enet | 32 | 0.00 | 5.6e-01 | -0.78 | -7.2 | 5.2e-13 | -0.04 | 0.08 | 0.04 | TRUE |
| 4 | GTEx | Artery Tibial | MPP7 | 0.17 | 0.03 | lasso | 9 | 0.06 | 3.6e-05 | -6.90 | -8.7 | 3.4e-18 | -0.06 | 0.67 | 0.06 | TRUE |
| 5 | GTEx | Heart Atrial Appendage | MPP7 | 0.26 | 0.06 | enet | 27 | 0.19 | 9.3e-09 | -6.96 | -6.5 | 7.1e-11 | 0.00 | 0.62 | 0.02 | FALSE |
| 6 | GTEx | Testis | ZNF438 | 0.23 | 0.21 | enet | 20 | 0.23 | 1.9e-10 | 2.94 | -7.2 | 5.5e-13 | -0.29 | 0.86 | 0.12 | TRUE |
| 7 | GTEx | Thyroid | SVIL | 0.15 | 0.00 | enet | 17 | 0.02 | 1.1e-02 | 1.84 | -5.2 | 2.4e-07 | -0.01 | 0.16 | 0.18 | FALSE |
| 8 | GTEx | Whole Blood | PTCHD3P1 | 0.16 | 0.07 | lasso | 8 | 0.06 | 4.2e-06 | 5.73 | -5.6 | 2.7e-08 | -0.07 | 0.04 | 0.96 | TRUE |
| 9 | METSIM | Adipose | MKX | 0.08 | 0.10 | lasso | 5 | 0.09 | 2.4e-13 | 7.10 | -8.2 | 2.6e-16 | -0.12 | 1.00 | 0.00 | TRUE |
| 10 | METSIM | Adipose | MPP7 | 0.09 | 0.08 | lasso | 4 | 0.07 | 6.4e-11 | 5.22 | -5.2 | 1.8e-07 | -0.01 | 1.00 | 0.00 | TRUE |
| 11 | METSIM | Adipose | YME1L1 | 0.05 | 0.03 | bslmm | 456 | 0.03 | 4.4e-05 | 2.88 | -5.2 | 1.7e-07 | 0.13 | 0.98 | 0.00 | TRUE |
| 12 | NTR | Blood | MPP7 | 0.03 | 0.01 | enet | 8 | 0.01 | 1.4e-05 | -6.90 | -7.9 | 2.1e-15 | -0.09 | 0.90 | 0.00 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | MKX | 0.08 | 0.04 | lasso | 5 | 0.05 | 1.4e-06 | 3.11 | 6.0 | 2.4e-09 | 0.12 | 0.97 | 0.02 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | MPP7 | 0.10 | 0.08 | lasso | 5 | 0.08 | 1.5e-10 | 3.60 | -5.4 | 8.1e-08 | -0.01 | 1.00 | 0.00 | TRUE |
| 15 | YFS | Blood | BAMBI | 0.27 | 0.25 | bslmm | 610 | 0.31 | 3.9e-104 | -3.92 | -5.8 | 8.6e-09 | -0.02 | 1.00 | 0.00 | FALSE |
| 16 | YFS | Blood | MPP7 | 0.04 | 0.03 | lasso | 8 | 0.03 | 1.9e-11 | 4.41 | -6.0 | 2.7e-09 | -0.09 | 1.00 | 0.00 | TRUE |
| 17 | YFS | Blood | SVIL | 0.16 | 0.12 | enet | 35 | 0.16 | 4.1e-50 | -3.36 | -5.9 | 3.7e-09 | 0.01 | 1.00 | 0.00 | TRUE |
| 18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZNF438 | 0.03 | 0.00 | blup | 123 | 0.02 | 1.8e-05 | 8.80 | 8.2 | 2.9e-16 | 0.38 | 0.15 | 0.62 | TRUE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZNF438 | 0.09 | 0.03 | enet | 10 | 0.03 | 7.1e-05 | 8.80 | 5.4 | 6.4e-08 | 0.33 | 0.52 | 0.05 | TRUE |