Hub : Genes

MPP7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0730	0.0310	2.1e-03	0.041	0.021	0.046	0.030	0.035	8.1e-06	1.0e-03	2.3e-06	1.2e-04	3.8e-05
2	GTEx	Artery Tibial	0.1723	0.0460	1.1e-05	0.031	NA	0.034	NA	0.055	1.6e-03	NA	1.1e-03	NA	3.6e-05
3	GTEx	Brain Cerebellum	0.2750	0.1030	7.7e-03	0.260	NA	0.176	NA	0.215	2.7e-08	NA	6.9e-06	NA	5.3e-07
4	GTEx	Esophagus Mucosa	0.2160	0.0700	5.7e-04	0.044	NA	0.061	NA	0.064	6.2e-04	NA	6.6e-05	NA	4.4e-05
5	GTEx	Heart Atrial Appendage	0.2630	0.0870	1.4e-03	0.061	NA	0.186	NA	0.128	9.9e-04	NA	9.3e-09	NA	2.3e-06
6	METSIM	Adipose	0.0853	0.0252	2.7e-05	0.077	0.031	0.061	0.067	0.072	1.2e-11	1.5e-05	1.9e-09	2.7e-10	6.4e-11
7	NTR	Blood	0.0254	0.0105	6.1e-03	0.011	0.006	0.014	0.010	0.014	1.0e-04	3.1e-03	1.4e-05	2.9e-04	1.6e-05
8	ROSMAP	Brain Pre-frontal Cortex	0.1027	0.0287	1.3e-06	0.078	0.062	0.076	0.066	0.080	3.1e-10	1.8e-08	5.5e-10	7.4e-09	1.5e-10
9	YFS	Blood	0.0427	0.0123	1.9e-06	0.034	0.022	0.028	0.029	0.034	2.7e-11	6.2e-08	1.2e-09	5.0e-10	1.9e-11
10	TCGA	Prostate Adenocarcinoma	0.0644	0.0244	2.1e-05	0.025	0.040	0.029	NA	0.032	1.1e-03	4.5e-05	4.3e-04	NA	2.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.9	1.4	4.6	-0.3	-1.9	0.4	-0.7	-0.9	-0.9	-2.1	-1.0	-1.6	-0.4
Bipolar Disorder or Schizophrenia	0.8	1.8	6.1	-0.6	-2.5	-0.9	-0.5	-1.9	-1.2	-1.6	-1.8	0.1	-0.1
Depressed Affect (Nagel 2018)	0.4	0.9	3.1	0.4	0.4	-0.1	-1.2	-0.2	-1.8	1.0	-0.5	0.8	1.3
Depression (Nagel 2018)	0.3	0.4	2.2	-0.4	-0.6	-1.5	0.4	0.1	0.1	-0.0	-0.6	-0.7	-0.3
Intelligence (Savage-Jansen 2018)	1.3	4.0	10.1	-2.7	-3.1	-0.5	3.2	-0.7	1.2	-1.2	-2.2	-0.3	-1.9
Neuroticism (Nagel 2018)	0.9	2.1	4.0	1.5	1.9	-0.1	-1.6	0.1	-2.0	1.9	0.3	0.8	2.0
Schizophrenia (2018)	0.7	1.4	2.7	-1.0	-1.6	-1.5	-0.2	-1.6	-0.8	-0.3	-1.6	1.5	0.1
Schizophrenia vs Biploar Disorder	1.0	1.4	3.2	1.6	-0.8	-1.6	1.8	1.0	1.8	-0.8	0.2	-0.0	-0.0
Worry (Nagel 2018)	1.6	3.4	7.6	2.8	2.6	0.8	-1.1	0.8	-1.3	1.5	2.6	-0.7	2.3
Alzheimer’s Disease (in mother)	1.7	2.0	5.8	-0.4	-2.4	-1.3	-0.1	-1.8	-0.4	-2.0	-0.7	-2.0	-1.0
Alzheimer’s Disease (in father)	1.0	1.1	4.1	0.5	0.5	-0.2	2.0	0.6	1.2	0.9	1.8	0.8	0.1
Alzheimer’s Disease (including proxy)	0.4	0.6	1.6	0.1	-1.0	-1.2	0.5	-0.2	0.8	-0.7	1.3	-0.7	-0.4
Crohns Disease (2017)	0.4	0.9	3.9	1.0	1.2	1.1	-0.3	0.0	0.2	0.5	2.0	-0.4	1.0
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	0.2	0.9	0.3	-0.5	-0.0	0.4	0.8	0.9	-0.3	0.8
Ulcerative Colitis (UC)	0.1	0.2	0.7	-0.8	-0.2	-0.0	-0.3	0.1	0.5	0.1	-0.7	-0.4	0.1
Major Depression (MDD)	0.3	0.4	1.0	0.3	-0.6	0.9	1.0	-0.8	-0.3	-0.7	-0.4	-0.4	-0.2
Reaction Time	0.8	1.5	3.7	-0.7	-0.6	-0.9	-1.9	-0.1	-1.9	1.2	-1.6	1.5	0.6
Verbal and Numeric Reasoning (VNR)	1.3	3.0	12.2	-2.9	-1.2	-0.1	3.5	0.1	2.4	-0.7	-0.7	-0.5	-1.1
Breast Cancer	0.3	0.7	2.0	-1.3	-0.6	-0.4	0.2	-1.4	0.1	0.3	-1.4	0.2	-0.5
Ovarian Cancer	0.4	0.5	1.6	-0.2	-0.5	1.3	1.0	0.3	0.7	-0.8	0.1	-1.1	-0.0
Prostate Cancer	0.8	1.2	4.7	0.2	-1.1	1.0	-0.4	-1.6	-0.8	-1.2	0.0	-2.2	0.2
Age at First Birth	1.7	2.5	7.6	0.9	0.3	1.3	-1.6	-0.6	-0.0	-1.7	2.6	-1.5	2.8
Bipolar Disorder (2011)	0.8	0.8	2.4	0.3	-0.7	-0.5	-0.2	-0.9	-1.6	-0.8	0.1	-1.3	1.1
Body Mass Index (BMI) (2010)	0.3	0.4	1.2	0.8	0.6	-0.9	0.2	0.1	-1.1	0.6	0.2	0.1	-0.7
Coronary Artery Disease (CAD)	0.7	0.8	2.9	0.7	-0.4	0.3	-0.3	-0.9	-0.4	-1.1	-0.7	-1.7	-1.2
Crohns Disease (2012)	0.5	0.9	2.0	0.8	1.0	1.3	-0.0	-0.9	-0.3	1.0	1.3	0.2	1.4
Mean Putamen Volume	1.3	1.5	3.8	0.3	1.9	0.7	0.5	1.9	1.0	1.7	1.2	0.6	0.8
Fasting Glucose	1.3	1.5	4.3	0.8	-0.6	0.4	-2.1	-1.1	-1.7	-1.4	-1.0	-1.3	0.8
HbA1C	2.0	2.2	5.2	-2.3	1.0	-1.8	1.4	-0.5	-0.6	1.8	-1.8	1.7	-0.8
HDL Cholesterol	1.1	1.8	6.3	2.5	-0.4	1.8	-0.7	-1.9	-1.1	-1.0	0.8	-1.2	0.4
LDL Cholesterol	1.6	2.6	12.3	-0.5	-0.3	0.8	-0.6	-3.5	-2.8	-1.2	0.2	-0.9	1.6
Lupus	1.4	2.1	4.2	-0.1	-1.7	-1.1	-1.0	-2.0	-1.7	-2.0	-1.1	-0.9	-1.6
Neuroticism (2016)	1.4	2.0	6.4	1.4	2.2	1.8	-1.1	0.7	-0.4	0.1	0.6	-1.2	2.5
Primary Biliary Cirrhosis	1.1	1.5	3.9	-1.4	-0.6	-1.2	-0.7	-1.1	-1.0	0.4	-1.9	1.1	-2.0
Rheumatoid Arthritis	0.2	0.3	0.7	-0.6	0.1	-0.2	-0.1	-0.9	-0.8	0.4	-0.6	0.8	-0.6
Schizophrenia (2014)	0.8	1.8	6.7	-0.1	-2.6	-1.8	0.6	-1.4	-0.4	-1.1	-1.9	0.2	-1.1
Triglycerides	0.4	0.7	4.8	-2.2	0.4	-0.1	-0.3	-0.6	-0.5	0.3	-0.9	0.2	-0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.4	2.0	0.5	0.4	0.5	0.6	0.4	0.3	0.4	0.7	-0.3	-1.4
Ulcerative Colitis	0.6	0.8	4.9	-1.0	-0.8	-2.2	-0.3	-0.4	0.4	0.4	-0.9	0.3	-0.5
Blood Eosinophil Count	0.8	6.2	14.4	0.4	3.7	-1.0	-3.8	3.7	0.4	2.7	2.3	1.6	1.9
Blood Platelet Count	0.3	3.2	7.2	-1.6	-2.3	-1.3	-1.2	-1.9	-2.7	-0.6	-2.5	1.3	-1.4
Blood Red Count	0.1	1.4	3.3	0.9	-0.6	-1.2	-0.8	0.9	0.6	1.4	-0.8	1.8	-1.8
Blood White Count	0.6	4.6	14.7	-0.5	1.2	-1.6	-2.8	3.8	0.3	2.8	-0.5	3.2	-0.7
Heel T-Score	3.9	31.1	75.7	-5.2	-8.7	1.2	2.0	-6.5	-5.2	-7.9	-5.4	-6.0	-2.6
BMI	0.3	2.0	5.1	1.1	2.1	-2.2	-2.0	0.4	-1.3	1.6	0.1	0.9	-0.1
Height	0.3	5.9	15.7	0.3	-2.2	1.8	1.3	1.7	3.4	-3.1	1.5	-2.8	4.0
Waist Hip Ratio (WHR)	0.5	2.1	8.1	1.5	1.5	-0.1	-1.7	-0.0	-1.3	1.6	0.4	2.8	1.2
Systolic Blood Pressure	0.4	2.1	8.7	0.2	0.8	-1.8	0.1	-1.2	-1.5	3.0	-0.0	1.9	0.8
Smoking Status	0.3	0.7	2.0	-1.1	-0.9	0.2	1.4	0.7	0.5	-0.2	-0.5	0.2	-1.4
Allergy or Eczema	0.4	1.0	4.0	0.3	-1.3	-2.0	-1.4	-0.6	-0.5	-0.0	-0.8	0.8	-0.7
Cardiovascular Disease	0.7	2.4	7.4	0.4	1.7	-2.7	-0.8	-1.0	-1.6	2.0	1.0	1.2	1.7
Hypothyroidism (self reported)	0.3	0.6	2.2	-0.8	0.2	0.1	0.1	0.3	1.1	-0.7	1.1	-1.5	0.7
Respiratory disease	1.3	3.0	10.4	1.3	-1.5	-0.5	-3.2	-1.7	-2.7	-1.8	-0.7	-1.2	-0.4
Type 2 Diabetes (T2D) (2018)	0.7	1.2	3.3	0.9	1.7	0.3	-1.1	0.8	-0.3	1.5	0.6	1.8	0.9
Lung FEV1/FVC ratio	0.3	1.3	5.7	-2.4	0.8	-0.8	0.4	-0.3	0.8	1.7	0.6	1.1	0.9
Lung FVC	0.9	4.5	16.5	-2.4	-0.7	0.6	4.1	1.6	2.9	-0.1	-0.9	-0.4	-3.1
Neuroticism	0.7	1.7	4.6	2.2	1.7	0.0	-0.7	-0.1	-2.0	1.3	0.9	0.5	1.5
Chronotype (morning person)	0.5	1.1	3.6	1.9	0.3	0.1	-1.0	-1.6	-1.3	-0.2	0.8	0.3	0.9
Hair Pigment	0.0	0.7	4.3	-0.7	-0.1	1.0	2.1	0.1	0.2	0.4	0.5	-1.0	-0.1
Tanning	0.1	1.1	2.6	0.9	1.6	0.8	-1.0	0.9	-0.6	1.6	0.9	0.9	0.8
Hand grip strength (left)	0.5	1.3	3.2	1.2	1.5	0.2	-0.9	0.9	-0.5	0.2	1.8	-0.8	1.8
Number of treatments/medications taken	0.5	0.8	3.3	1.8	0.3	-1.4	-1.0	-0.2	0.8	-0.1	1.2	0.4	-0.1
Average weekly spirits intake	1.2	1.5	4.9	1.2	0.8	2.2	-2.0	1.2	0.1	0.2	1.4	-0.9	-0.4
Sensitivity / hurt feelings	2.1	3.6	9.2	2.7	2.5	0.5	-3.0	-0.2	-2.6	0.7	1.3	-0.2	2.0
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.7	-0.8	-0.6	-0.6	0.5	-0.7	-0.7	0.0	-1.3	0.3	-0.6
Hearing difficulty/problems: Yes	0.7	1.0	3.9	0.1	-0.8	-0.0	-0.6	1.3	0.2	0.6	-1.2	1.4	-2.0
Relative age of first facial hair	0.3	0.6	3.6	0.4	0.8	0.5	-1.9	0.8	-0.7	-0.4	0.2	0.2	0.2
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	4.8	0.4	0.2	-2.2	-0.1	1.2	1.7	1.1	0.2	0.3	-0.7
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	-1.0	0.7	0.2	1.0	1.0	0.4	0.8	-0.0	1.0	0.1
Ever had hysterectomy (womb removed)	2.2	2.5	6.6	0.3	1.1	2.6	-0.1	1.8	2.2	-0.8	1.8	-1.8	1.3
Systolic blood pressure, automated reading	0.7	1.9	7.3	0.5	0.8	-1.6	1.1	-0.3	0.4	2.6	-0.1	2.7	-0.4
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.2	0.2	0.6	-0.4	1.2	1.5	0.3	1.8	-0.4	1.6	-1.5
Angina	1.2	1.6	5.5	-0.5	2.2	0.4	-0.7	0.8	-0.8	2.4	0.9	1.3	1.2
Medication for hormone replacement therapy	0.4	0.4	1.8	1.1	-0.0	0.8	1.3	0.2	0.1	-0.0	0.3	0.2	0.4
Vitamin and mineral supplements	0.2	0.3	1.4	0.6	-0.6	-0.5	1.2	-0.3	0.6	-0.3	-0.1	0.4	-0.1
Supplements: Zinc	0.5	0.6	1.8	-1.2	0.3	1.3	-1.3	0.2	-0.3	0.0	0.1	-0.6	0.1
Medication: Co-codamol	0.7	0.8	2.2	1.3	0.3	-1.5	0.3	-0.3	0.2	0.6	-0.1	1.5	-1.2
Medication: Metformin	2.0	2.8	7.2	1.0	2.6	0.8	-2.0	0.1	-1.1	2.7	0.5	2.5	1.1
Diabetes (father)	0.6	0.7	1.5	1.1	1.2	0.4	-0.8	0.8	0.0	1.0	-0.3	0.8	-1.2
Diabetes (mother)	0.8	1.1	5.5	0.4	0.8	-0.7	-1.5	1.0	0.1	0.7	-0.2	2.4	-0.2
Severe depression (siblings)	0.7	0.8	1.6	-0.9	0.1	1.3	1.1	-0.9	-1.2	0.9	-0.8	-0.1	-0.2
Pack years adult smoking proportion	0.9	1.3	2.8	1.6	1.7	0.3	-1.6	1.2	1.0	1.1	0.9	1.0	0.1
Impedance of leg (right)	0.1	0.7	2.5	-0.3	0.8	0.1	0.7	0.1	0.6	0.9	1.2	0.9	1.6
Leg fat-free mass (left)	0.2	0.8	2.3	-0.4	-0.9	-0.5	-1.1	0.0	0.1	-1.2	-0.0	-1.3	1.5
Trunk fat percentage	0.1	0.6	2.0	0.7	1.1	-0.9	-1.4	-0.4	-0.8	0.6	0.3	0.4	0.2
Hand grip strength (right)	0.5	1.4	6.0	0.8	1.0	1.3	-0.8	-0.5	-1.3	-0.5	1.1	-0.9	2.4
Townsend deprivation index at recruitment	0.3	0.4	1.2	-0.1	-0.9	0.3	-0.3	-0.6	0.4	-0.2	-1.1	0.8	-0.9
Current tobacco smoking	0.3	0.4	1.7	0.6	0.4	0.1	-0.3	1.3	1.0	0.3	0.7	0.7	-0.3
Average weekly fortified wine intake	0.6	0.7	2.7	-0.7	0.5	-0.6	0.3	0.2	-0.5	1.6	-1.0	1.2	0.4
Maternal smoking around birth	0.3	0.4	1.8	0.0	0.6	0.3	-1.4	0.0	-1.2	0.3	-0.3	0.1	0.4
Fed-up feelings	0.4	0.7	4.7	0.4	0.6	0.3	-2.2	-0.6	-1.2	0.0	-0.1	0.4	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.8	-1.6	-0.7	-1.6	-0.6	0.2	0.2	0.4	-1.7	0.1	-1.1
Relative age voice broke	1.0	1.6	5.8	1.0	0.0	1.6	-2.4	1.3	0.0	-1.7	0.1	-1.2	0.5
Taking other prescription medications	0.6	0.9	3.0	1.1	1.0	-0.9	-1.7	0.6	0.3	0.4	1.4	0.2	0.5
Age when periods started (menarche)	0.2	0.5	1.9	0.2	-0.3	1.2	1.4	-0.1	1.1	-0.3	-0.0	-0.4	-0.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	1.7	1.1	-0.6	0.9	-1.0	-0.2	0.5	-1.3	0.8	-0.4	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	7.0	-0.5	-2.5	0.5	1.9	-2.6	-1.7	-2.5	-1.1	-1.8	0.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	1.0	0.2	-0.5	-0.5	-0.3	0.5	0.4	0.2	-0.4	0.1	-1.0
Qualifications: CSEs or equivalent	0.3	0.4	1.9	0.0	0.4	-0.1	0.8	1.0	0.6	0.3	-0.1	0.2	-1.4
Serious illness, injury or assault to yourself	1.7	2.0	5.6	0.9	0.5	1.3	-2.0	-2.4	-1.8	-1.0	0.3	-1.6	0.8
High blood pressure	0.9	2.4	6.8	0.1	2.0	-2.2	0.1	0.1	-0.2	2.6	1.0	2.4	1.1
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.5	0.4	-1.3	-1.9	-0.2	-0.5	-0.3	0.1	-0.6	1.1	-1.1
Multivitamins +/- minerals	0.7	0.9	3.8	0.4	0.7	0.6	-2.0	-1.1	-0.9	0.2	0.5	-0.1	1.2
Stomach or abdominal pain in last month	1.0	1.3	4.4	1.3	2.1	0.3	-0.5	0.5	-0.1	0.4	1.5	-0.3	1.9
Supplements: Glucosamine	0.4	0.5	2.0	-0.9	-0.4	-0.6	0.2	-1.4	0.4	-1.0	0.1	-0.5	-0.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.2	0.6	0.5	-0.9	0.4	1.5	0.8	0.6	0.1	1.5	0.6
Medication: Atenolol	1.7	2.1	5.5	-0.1	2.2	0.1	0.8	1.3	1.3	2.4	1.6	1.4	1.2
Medication: Levothyroxine sodium	0.4	0.6	2.4	-1.2	0.2	-1.1	0.1	0.4	1.5	0.4	0.6	0.6	0.2
Sitting height	0.4	3.1	11.4	-0.7	-2.5	0.6	-0.3	-1.2	0.4	-2.3	-0.2	-2.3	3.4
Chronic bronchitis/emphysema (father)	1.1	1.3	8.1	-0.3	-0.1	-0.7	-2.8	-0.7	-1.4	-0.5	-0.9	0.6	0.2
High blood pressure (mother)	0.6	0.8	3.2	-0.1	1.2	-0.9	0.8	0.7	0.9	0.6	1.8	-0.2	0.5
Body mass index (BMI)	0.4	1.6	6.2	1.1	1.8	-1.3	-2.5	0.0	-1.4	0.8	0.4	0.8	0.3
Impedance of leg (left)	0.2	1.0	2.5	0.7	1.3	0.5	0.6	0.1	0.4	1.2	1.4	0.9	1.6
Leg predicted mass (left)	0.2	0.8	2.6	-0.4	-0.9	-0.4	-1.1	0.0	0.1	-1.2	-0.0	-1.3	1.6
Trunk fat mass	0.2	0.8	3.1	0.9	1.1	-0.8	-1.8	-0.3	-0.7	0.3	0.5	0.1	1.2
Waist circumference	0.7	2.5	7.8	1.2	2.4	-1.1	-2.8	0.3	-0.7	1.3	0.9	1.7	1.8
Number of incorrect matches in round	1.2	2.0	11.8	0.2	1.0	0.5	-3.4	-0.1	-2.4	-0.1	-0.2	-0.7	0.7
Past tobacco smoking	0.8	1.4	3.5	1.8	0.6	1.5	-1.9	-0.8	-0.9	-0.3	0.6	-0.6	1.7
Alcohol usually taken with meals	0.3	0.6	2.2	-0.5	-1.5	-0.6	1.0	-0.4	0.9	-0.7	-0.1	-0.5	-0.4
Nervous feelings	0.8	1.5	5.3	2.3	1.4	0.5	-1.2	-0.2	-1.7	1.1	1.2	-0.6	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	6.4	-0.4	-0.7	-1.0	-1.0	-0.9	-2.5	-0.1	-1.8	0.3	-0.3
Hearing difficulty/problems with background noise	0.6	0.9	3.5	1.2	0.3	0.2	-1.0	1.9	0.0	0.4	-0.8	1.2	-0.9
Hair/balding pattern: Pattern 2	1.2	1.5	3.7	-1.4	-0.7	-1.6	-1.6	-0.4	-1.9	0.2	-1.6	1.2	0.0
Had menopause	0.6	0.8	2.9	-1.7	0.1	-0.2	0.4	0.2	1.0	0.6	-0.8	1.6	0.3
Had other major operations	0.5	0.7	1.9	-0.3	0.2	-1.0	-0.1	-1.4	-0.9	0.7	-0.8	1.3	-0.2
Forced vital capacity (FVC)	0.7	2.8	14.4	-0.9	-1.2	0.2	3.8	1.8	2.6	-0.1	0.3	-0.7	0.1
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.8	12.2	-1.4	-3.0	-0.2	1.2	-3.5	-3.0	-2.6	-1.7	-2.2	-0.0
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	4.8	2.2	0.4	0.3	0.9	-0.6	-1.1	-0.5	1.0	-1.2	0.5
Qualifications: None of the above	0.7	1.4	6.3	2.5	2.0	0.6	-0.6	-0.3	-0.8	0.5	0.9	0.5	1.0
Financial difficulties in last 2 years	0.7	1.0	4.1	0.7	0.5	-0.3	-2.0	-0.1	-1.8	1.2	-0.2	0.7	-0.2
Mouth/teeth dental problems	1.4	2.1	5.5	0.4	-2.0	-0.0	-0.1	-1.8	-1.3	-2.4	-1.3	-2.0	-0.4
Heart attack	0.3	0.4	1.7	-0.0	0.1	-0.4	-0.5	-0.4	0.2	0.7	-1.0	1.3	-0.4
Allergy	0.4	1.0	2.8	-0.7	1.4	1.7	0.3	1.0	0.5	0.6	0.4	-0.4	1.6
Pain all over the body in last month	1.6	1.7	6.1	-1.2	-2.5	1.1	0.9	-0.8	-0.1	-1.8	-1.0	-0.9	-1.4
Diabetes (self-reported)	1.1	1.7	7.0	-0.2	1.1	0.5	-2.2	0.5	-0.8	1.4	-0.9	2.6	0.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.1	0.8	-1.5	1.2	-0.5	-0.3	-0.3	-1.0	0.5	-0.7	0.3
Medication: Ramipril	0.4	0.6	2.0	-0.1	1.0	0.3	0.3	0.0	-0.5	0.6	1.4	0.2	1.4
Medication: Simvastatin	0.2	0.3	1.0	-0.4	0.0	-0.2	1.0	-0.7	0.5	0.1	-0.5	0.8	-0.6
Fluid intelligence score	0.8	1.7	5.5	-2.0	-0.7	0.4	2.2	0.4	2.3	-0.6	0.2	-1.0	-0.2
Illnesses of siblings	0.9	1.2	3.0	-1.7	-1.6	0.2	-0.7	0.3	0.5	-1.0	-1.2	-1.0	-1.5
Neuroticism score	0.6	1.2	5.0	2.2	1.0	0.2	-1.3	0.1	-1.8	0.3	0.6	0.1	0.7
Weight	0.2	1.2	4.4	0.6	0.9	-1.1	-2.0	0.3	0.1	0.0	1.0	-0.1	2.1
Impedance of arm (right)	0.1	0.7	2.9	-0.7	-1.1	-0.1	1.7	-0.2	0.4	0.4	-0.7	0.0	-1.3
Arm fat percentage (right)	0.3	1.1	3.2	0.8	1.3	-1.1	-1.8	-0.5	-1.6	0.8	-0.2	0.7	-0.3
Trunk fat-free mass	0.3	1.5	10.5	-0.2	-0.1	-0.2	-1.2	0.5	0.7	-1.0	0.9	-0.8	3.2
Hip circumference	0.2	0.7	2.5	0.1	1.1	-0.6	-1.0	0.4	0.2	0.4	1.1	0.1	1.6
Time employed in main current job	0.3	0.3	1.8	0.3	0.5	0.3	-0.5	0.3	0.5	0.3	1.3	-0.3	0.6
Alcohol intake versus 10 years previously	1.5	2.3	8.3	-1.2	-1.0	-0.9	-1.1	-1.4	-1.8	0.8	-2.9	1.4	-1.4
Father’s age at death	1.6	2.1	4.9	-0.6	-2.0	0.6	0.5	-1.8	-1.4	-1.1	-2.2	-0.9	-1.9
Worrier / anxious feelings	0.9	1.7	3.6	1.9	1.9	-0.2	-1.3	1.1	-1.0	1.3	1.5	-0.3	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	2.0	0.5	0.5	-1.4	-1.4	0.7	-0.2	0.8	-0.7	1.2	0.3
Falls in the last year	0.7	1.0	4.1	-0.7	-1.0	1.1	-0.7	-0.7	-2.0	-0.1	-1.4	0.1	-0.6
Hair/balding pattern: Pattern 3	0.3	0.4	1.0	0.7	-1.0	-0.2	0.2	-0.8	0.3	-1.0	-0.4	-0.7	-0.6
Number of live births	0.3	0.5	1.5	1.2	0.9	0.2	0.2	-0.4	-0.2	-0.3	0.2	-0.8	1.2
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	12.9	-1.7	-0.8	0.3	3.6	1.5	2.5	0.5	0.6	-0.8	0.3
Pulse rate	0.5	0.9	2.6	0.4	-1.0	-1.6	-1.1	-1.1	-0.1	-0.3	-1.2	0.6	0.9
Happiness	1.0	1.2	3.1	1.8	1.2	-0.1	-1.4	0.4	-1.5	0.7	0.4	1.0	1.2
Noisy workplace	0.2	0.3	1.0	-0.1	0.4	0.4	-0.3	-0.3	-0.4	1.0	-0.2	0.9	-0.4
Qualifications: A levels/AS levels or equivalent	0.8	1.7	4.8	1.1	-0.7	0.7	-0.8	-1.8	-0.9	-1.4	1.1	-1.4	2.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	3.0	1.0	-0.7	0.9	-0.4	-0.3	-0.7	-1.2	0.4	-1.7	0.2
Mouth/teeth dental problems: Dentures	0.5	0.9	2.5	0.5	1.6	0.8	-1.5	0.5	-0.0	1.3	0.3	1.0	0.3
Asthma	1.0	2.0	4.6	1.0	-1.6	0.4	-1.8	-1.4	-1.9	-2.1	0.1	-1.6	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.3	0.7	-0.5	1.3	-0.6	0.1	-0.4	-1.5	-0.0	-1.0	0.7
Medication: Cholesterol lowering	0.6	1.0	4.6	-0.1	0.2	-1.0	0.0	-0.6	0.1	1.6	-0.5	2.1	-0.9
Depression (self-reported)	0.6	0.7	2.2	-0.0	0.8	0.2	-0.5	1.5	0.2	1.2	0.6	1.2	0.9
Medication: Lansoprazole	0.8	0.9	3.8	-0.0	1.2	1.0	-0.5	-1.9	-1.4	-0.4	0.4	-0.1	0.3
Prospective memory result	1.2	1.5	5.5	1.1	-0.4	-1.0	-2.3	-1.9	-1.6	-0.8	-0.2	-0.6	0.5
Lung cancer (father)	0.6	0.7	3.8	-0.9	0.3	-0.5	-1.9	1.1	0.4	-0.3	-0.8	0.5	0.0
Illnesses of mother	0.1	0.1	0.2	-0.0	-0.4	0.4	-0.5	0.1	-0.4	0.4	-0.2	-0.2	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	14.3	-2.1	-0.7	-0.0	3.8	1.3	2.2	1.1	0.1	-0.1	-0.2
Pulse wave Arterial Stiffness index	0.6	0.7	3.8	-0.8	0.5	-0.0	-2.0	0.3	-1.1	0.8	-0.4	0.3	0.4
Impedance of arm (left)	0.1	0.7	3.5	-0.2	-1.2	0.4	1.9	-0.3	0.3	0.3	-0.6	-0.1	-0.9
Arm fat mass (right)	0.2	1.0	4.1	0.8	1.4	-1.0	-2.0	-0.1	-1.1	0.5	0.4	0.3	0.7
Trunk predicted mass	0.3	1.6	10.9	-0.0	-0.2	-0.3	-1.2	0.5	0.7	-1.0	1.0	-0.8	3.3
Standing height	0.4	3.9	21.5	-0.7	-1.5	0.3	0.5	0.4	2.6	-1.6	1.6	-1.7	4.6
Length of working week for main job	0.9	1.0	3.5	0.8	0.3	-1.3	-0.1	0.0	-1.9	1.0	-0.1	1.4	1.1
Exposure to tobacco smoke at home	1.4	1.6	5.7	0.6	-0.1	-0.3	-2.3	-2.4	-1.4	-0.9	-0.3	-1.2	0.7
Breastfed as a baby	2.1	2.6	7.7	-0.8	-2.3	-0.4	1.3	-0.3	1.8	-2.8	0.8	-2.2	-1.0
Tense / ‘highly strung’	2.0	3.3	9.1	2.2	3.0	2.0	-2.0	0.8	-1.4	0.7	1.8	-1.0	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.5	-0.2	-0.1	0.1	0.7	0.1	-1.2	-0.5	-0.5	-0.9	-0.6
Hair/balding pattern: Pattern 4	1.2	2.9	7.9	0.2	2.2	0.5	-0.1	1.7	2.1	1.8	2.8	0.9	2.0
Birth weight of first child	0.8	1.5	3.8	-1.7	-1.9	-1.2	0.7	-0.6	0.2	-0.7	-1.6	0.3	-1.7
Peak expiratory flow (PEF)	0.7	1.6	5.3	-1.1	-1.2	0.6	1.9	-0.4	0.7	-1.2	1.0	-2.3	0.9
Pulse wave reflection index	0.5	0.6	2.2	-0.3	0.8	0.7	-1.0	-0.5	-1.5	0.7	-0.3	0.1	0.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.6	0.6	-1.1	-0.4	0.0	-0.0	0.3	-0.1	-1.3	1.1	-1.2
Loud music exposure frequency	0.5	0.6	2.4	1.5	1.0	0.9	-0.3	0.6	0.0	0.7	0.1	0.9	0.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.9	-0.6	0.2	-0.1	0.9	0.1	0.9	1.7	0.2	0.9	-0.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.3	-0.4	0.4	-1.1	1.1	0.9	1.0	0.4	0.2	0.8	0.7
Blood clot in the leg (DVT)	0.7	0.9	4.8	0.1	1.4	-0.3	-0.5	-0.9	0.4	0.4	1.0	-0.0	2.2
Medication: Paracetamol	0.3	0.5	1.0	0.9	-1.0	-1.0	0.4	-0.6	-0.3	-1.0	-0.0	-0.3	-0.5
Headache pain in last month	0.8	1.4	3.0	-1.5	-0.5	0.5	-1.2	-1.7	-1.4	-1.5	-0.9	-1.3	-0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.9	-0.1	-0.7	1.4	-0.5	0.9	-0.4	-1.0	-0.3	-1.3	-0.6
Glaucoma (self-reported)	1.0	1.2	4.3	-0.4	-0.4	-1.4	2.1	-1.0	-0.5	-0.9	0.6	-1.4	0.9
Gout (self-reported)	2.5	3.4	11.0	2.2	2.9	1.8	-0.5	0.5	-0.2	0.2	3.3	-1.6	1.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.0	0.5	0.9	-0.6	-0.7	0.3	1.4	0.3	1.4	-0.1	0.3
Medication: Amlodipine	1.1	1.5	3.6	1.5	1.8	0.1	-0.1	-0.6	-1.2	1.9	1.1	0.8	1.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.7	0.1	-1.1	0.2	0.8	0.3	0.0	-1.3	0.5	-0.3	-0.2
Birth weight	0.3	0.7	3.2	-1.6	0.1	-1.8	-0.1	0.7	0.4	0.2	0.1	0.5	-0.1
Chronic bronchitis/emphysema (mother)	0.8	1.0	4.0	0.2	1.0	0.6	-2.0	-0.7	-1.6	0.8	-0.3	0.4	-0.7
High blood pressure (siblings)	0.8	1.2	3.6	0.8	1.7	-0.3	-0.1	-0.9	-1.4	0.5	1.0	0.6	1.9
Forced vital capacity (FVC), Best measure	0.7	2.7	14.2	-1.5	-0.7	0.3	3.8	1.8	2.5	0.6	0.3	-0.2	0.1
Body fat percentage	0.3	1.0	3.1	1.0	1.6	-1.1	-1.8	-0.2	-0.8	1.0	0.5	0.8	0.3
Leg fat percentage (right)	0.5	2.0	5.4	1.1	2.1	-1.9	-2.3	0.2	-0.5	1.2	1.0	1.4	0.8
Arm fat-free mass (right)	0.2	1.3	9.5	0.3	0.3	-0.6	-1.1	0.1	0.3	-0.5	1.0	-0.4	3.1
Exposure to tobacco smoke outside home	2.1	2.8	7.1	1.9	0.2	-1.6	-2.5	0.1	-1.4	1.5	-1.7	2.7	-1.2
Comparative body size at age 10	0.7	1.9	6.4	-0.2	1.6	-0.3	0.1	2.5	1.7	0.4	2.5	-0.5	0.6
Number of full brothers	0.8	1.0	3.4	-1.3	0.2	-0.0	1.8	-0.3	0.5	0.9	-0.1	-0.2	-1.8
Worry too long after embarrassment	1.5	2.5	8.8	3.0	1.4	0.8	-1.1	1.6	-0.4	-0.5	1.7	-1.2	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	3.1	1.4	0.4	1.0	0.6	0.1	-1.8	-0.1	0.7	-0.7	0.1
Wheeze or whistling in the chest in last year	0.4	0.8	2.8	1.7	0.7	0.1	0.9	0.3	-0.6	-0.6	1.7	-0.2	0.0
Number of children fathered	0.3	0.3	2.0	-0.1	0.0	-0.4	-1.4	0.3	0.4	-0.4	-0.3	0.6	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.3	-0.2	-0.5	0.6	-0.6	0.5	-0.6	-1.5	-0.4	-0.9	1.3
Age at first live birth	0.5	0.9	2.8	0.5	-0.6	0.7	-0.4	1.1	1.7	-1.2	1.2	-0.1	0.8
Pulse wave peak to peak time	0.7	0.9	4.3	0.8	-0.6	0.3	2.1	-0.2	1.3	-1.0	0.6	-0.5	-0.1
Health satisfaction	0.6	0.8	2.3	0.7	1.4	0.5	0.3	1.4	0.2	1.5	0.6	0.8	0.1
Shortness of breath walking on level ground	0.4	0.4	1.1	-0.7	0.6	0.2	0.1	0.6	1.0	0.8	0.5	1.0	0.0
Qualifications: College or University degree	0.4	1.2	4.8	-1.1	-2.2	-0.1	0.7	-1.7	-0.4	-1.0	-0.2	-0.4	1.0
Eye problems/disorders: None of the above	0.2	0.3	0.8	0.5	-0.3	0.3	-0.9	0.8	-0.0	-0.3	-0.6	-0.3	0.2
Mouth/teeth dental problems: Loose teeth	1.2	1.4	5.4	0.1	0.8	-0.5	0.3	2.3	1.5	1.2	-0.2	1.8	-0.9
Emphysema/chronic bronchitis	0.6	0.7	3.0	-0.5	-0.2	-0.8	0.2	0.1	1.3	0.4	-0.2	1.2	-1.7
Medication for pain relief, constipation, heartburn	0.3	0.5	2.9	-1.7	-0.5	0.5	0.8	-0.5	-0.5	0.7	-0.5	-0.1	-0.1
Neck or shoulder pain in last month	0.5	0.6	2.0	0.3	1.3	-0.3	-1.4	-0.7	0.5	0.7	0.8	0.7	0.6
Medication: Blood pressure	0.5	0.9	2.2	0.0	0.9	-1.1	1.5	-0.4	0.9	0.7	1.2	0.7	1.0
Angina (self-reported)	1.1	1.5	4.8	-0.6	1.9	0.3	-0.9	0.8	-0.8	2.2	0.7	1.2	1.2
Migraine (self-reported)	0.6	0.7	1.6	-0.9	-0.1	0.4	-1.3	-1.2	-0.8	-1.0	0.1	-0.5	1.0
Medication: Ibuprofen	0.7	0.9	3.4	-0.2	-1.0	1.0	-1.0	-0.4	-0.8	-1.8	-0.2	-1.1	0.5
Medication: Allopurinol	3.8	5.0	14.9	2.5	3.7	2.2	0.3	1.1	0.7	0.7	3.9	-0.9	2.7
Medication: Omeprazole	0.6	0.7	2.3	-0.6	-0.7	-0.3	-0.9	0.5	-0.1	-1.5	-0.9	-1.5	-0.5
Medication: Seretide 50 evohaler	1.4	1.6	8.6	0.2	0.9	1.0	-2.9	-0.3	-0.4	-0.9	1.4	-1.4	1.0
Mean time to correctly identify matches	0.3	0.5	1.6	-0.4	-0.3	0.0	-1.3	0.8	-0.3	0.6	-0.6	1.1	0.7
Heart disease (mother)	0.2	0.3	1.2	0.4	0.2	-0.8	-0.2	0.4	1.1	-0.1	0.6	0.2	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.0	-0.3	-0.7	0.0	-0.1	-0.4	-1.4	0.6	-1.2	0.7	-1.1
Whole body fat mass	0.2	0.9	3.4	0.8	1.3	-1.1	-1.8	-0.2	-0.6	0.5	0.5	0.4	1.2
Leg fat mass (right)	0.4	1.6	6.1	0.8	1.8	-1.5	-2.5	0.1	-0.5	0.8	0.8	0.9	1.3
Arm predicted mass (right)	0.2	1.3	8.9	0.3	0.2	-0.4	-1.3	-0.1	0.3	-0.7	0.9	-0.5	3.0
Pulse rate, automated reading	0.6	2.1	6.4	-1.3	-2.0	-2.4	-0.5	-0.2	0.5	-0.0	-2.5	1.4	-0.6
Alcohol intake frequency.	0.8	1.9	7.5	0.1	-0.6	-1.1	1.2	-0.5	-0.3	1.4	-1.8	1.7	-2.7
Comparative height size at age 10	0.6	3.3	13.4	0.6	1.0	0.7	-0.9	0.6	1.5	-0.9	2.8	-2.2	3.7
Number of full sisters	0.6	0.7	3.5	-0.3	-0.4	-1.9	0.8	-0.2	-0.2	0.5	0.4	0.6	-1.2
Suffer from ‘nerves’	0.6	1.0	2.8	1.6	1.2	0.6	-1.1	-0.2	-1.0	1.7	0.7	0.3	0.5
Overall health rating	0.6	1.3	3.5	1.3	0.9	-1.9	-0.6	0.9	-0.4	1.6	-0.3	1.8	0.1
Chest pain or discomfort	0.7	1.1	2.1	-1.2	-0.4	-1.1	1.5	-1.1	-1.4	0.6	-0.5	1.0	-1.0
Had major operations	2.6	3.0	8.4	2.6	2.5	1.4	0.5	-0.3	0.3	0.3	2.9	-1.6	1.8
Age at last live birth	0.2	0.4	1.9	-0.1	0.1	0.2	-0.4	1.4	0.6	-0.2	0.3	0.8	0.6
Family relationship satisfaction	1.4	1.7	4.4	-1.2	0.0	-1.5	1.5	-1.6	-1.5	1.0	-0.7	2.1	-0.3
Leg pain on walking	0.5	0.6	1.5	0.6	-0.0	-0.1	-1.0	-1.2	-1.2	-0.0	-1.0	-0.1	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	5.6	1.2	0.5	-0.2	-2.4	-0.1	-0.8	-0.2	0.3	0.6	1.1
Commuting to job workplace: Car/motor vehicle	1.5	1.7	5.1	-0.3	2.3	-1.1	-0.8	1.1	-0.9	2.0	0.3	2.0	0.3
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	7.2	-1.5	-0.0	0.1	2.7	1.1	2.0	0.5	0.4	1.4	-0.0
Medication: Aspirin	0.7	1.0	2.1	0.5	1.4	-0.6	-1.5	1.1	1.4	1.0	0.4	0.7	0.6
Supplements: Vitamin C	0.6	0.7	3.0	-1.7	-0.7	0.3	1.2	0.9	0.2	-0.1	-0.7	0.4	-0.5
Knee pain experienced in last month	1.2	1.8	4.2	-1.1	-0.6	-1.6	-0.2	-1.3	-1.6	0.9	-1.7	2.0	-1.4
Hypertension (Self-reported)	0.9	2.5	6.8	-0.1	2.2	-2.2	0.2	-0.0	-0.2	2.6	0.9	2.3	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.7	0.1	0.3	0.7	-0.6	0.6	0.2	-1.2	0.4	-0.7	1.6
Illnesses of father: Heart disease	1.1	1.5	4.3	0.5	1.0	-0.1	0.2	1.9	1.7	0.4	2.1	0.7	1.4
Illnesses of siblings: Diabetes	0.7	0.9	3.5	0.6	-0.1	-1.2	-1.1	0.5	0.3	1.0	-0.3	1.9	-0.8
Smoking status: Previous	0.7	1.0	2.6	-1.6	-0.9	-1.1	1.6	-0.1	0.1	-0.0	-0.9	0.2	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.0	0.5	-0.7	-0.1	0.8	-0.3	0.6	-1.3	1.1	-1.4	1.7
Whole body fat-free mass	0.2	1.2	7.4	-0.2	-0.3	-0.3	-1.2	0.3	0.4	-1.0	0.6	-1.0	2.7
Leg fat-free mass (right)	0.1	0.7	2.5	-0.0	-0.8	-0.1	-1.0	-0.1	0.0	-1.1	0.0	-1.4	1.6
Arm fat percentage (left)	0.2	1.0	2.2	1.0	1.2	-1.2	-1.5	-0.4	-1.5	0.8	-0.3	0.9	-0.3
Average weekly red wine intake	1.0	1.4	5.5	-0.3	-1.2	0.3	1.5	1.5	2.4	-1.3	0.6	-0.6	-0.3
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.4	0.4	-0.7	-1.2	-1.1	-1.4	-1.8	-0.5	-1.5	0.1	-0.7
Mood swings	0.6	1.2	3.1	0.8	0.4	1.0	-1.7	-0.5	-1.7	-0.9	0.2	-0.2	1.8
Loneliness, isolation	1.1	1.5	4.6	-1.0	-1.0	-1.8	-1.6	-0.5	-0.9	0.2	-2.1	1.2	-0.0
Long-standing illness, disability or infirmity	1.2	1.9	7.2	1.2	0.6	-2.5	-2.7	0.8	-0.4	0.8	-0.1	1.2	-0.9
Ever had bowel cancer screening	0.8	1.0	2.5	0.1	0.6	1.6	-1.3	-0.1	1.0	-0.9	1.2	-1.0	0.7
Diabetes diagnosed by doctor	1.0	1.7	6.4	0.3	1.5	0.5	-2.1	0.6	-0.4	1.6	-0.2	2.5	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.4	-0.3	-0.3	0.1	0.4	1.2	-0.0	-1.2	-0.1	-1.0	-0.2
Friendships satisfaction	0.4	0.5	1.7	0.5	-0.0	-1.2	1.1	-1.3	-0.0	0.1	0.4	0.6	-0.3
Qualifications: nursing, teaching	0.9	1.4	4.2	1.0	-0.4	1.6	0.3	-0.3	-0.0	-1.6	1.2	-2.0	1.1
Commuting to job workplace: Walk	0.4	0.4	2.2	0.5	-0.8	0.3	0.7	-0.2	0.7	0.1	0.1	0.2	1.5
Eye problems/disorders: Cataract	0.6	0.7	3.4	-0.2	1.3	1.8	0.5	-0.7	0.3	0.9	0.2	0.8	0.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.6	-0.4	0.3	-0.7	0.9	-0.3	0.2	0.8	1.2	0.0	-0.8
Medication for cholesterol	0.7	1.1	2.5	-1.4	-1.2	-0.1	-0.3	-0.5	-1.1	-1.3	-1.6	-1.3	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.1	0.4	-0.2	0.5	-1.5	-0.3	-1.1	-0.4	-0.5	-0.3	0.7
Back pain experienced in last month	1.4	2.0	6.7	1.4	2.1	0.2	-0.6	1.4	0.5	1.2	2.6	0.0	1.7
Mineral and other dietary supplements	0.5	0.6	1.7	0.6	-1.3	-0.9	0.1	1.3	-0.3	-0.8	-0.3	-0.9	-0.3
Breast cancer (self-reported)	0.2	0.3	1.3	1.1	0.7	0.1	0.2	-0.4	0.3	0.6	0.6	-0.2	0.4
Asthma (self-reported)	0.9	1.8	4.6	0.9	-1.6	0.2	-1.5	-1.3	-1.7	-2.1	0.2	-1.5	-0.9
Osteoporosis (self-reported)	0.4	0.5	1.4	-0.0	-0.3	-0.6	0.8	-0.2	-0.2	1.2	-0.5	1.0	-1.1
Osteoarthritis (self-reported)	0.4	0.5	2.1	0.4	0.0	0.1	0.8	-0.9	0.1	-1.4	-0.0	-1.3	-0.1
Medication: Aspirin	0.7	0.9	1.7	0.6	1.1	-0.9	-1.3	0.8	1.3	1.1	0.3	1.0	0.4
Medication: Gliclazide	0.4	0.4	1.6	0.4	1.3	0.4	-0.3	0.7	-0.6	0.4	-0.6	0.8	-0.6
Illnesses of father: None of the above (group 1)	0.6	0.7	1.9	-0.8	-0.6	1.1	0.4	0.4	0.5	-0.9	-1.0	-1.4	-0.9
Smoking status: Current	0.2	0.4	1.6	0.3	0.3	-0.2	-0.4	1.3	0.9	0.2	0.4	0.6	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	4.9	0.6	0.4	0.8	2.2	0.9	1.1	2.1	0.4	0.9	-0.3
Whole body water mass	0.2	1.1	7.0	-0.3	-0.4	-0.4	-1.2	0.2	0.3	-0.9	0.5	-0.9	2.6
Leg predicted mass (right)	0.1	0.8	2.8	-0.1	-0.8	-0.0	-1.0	-0.1	0.1	-1.1	0.1	-1.4	1.7
Arm fat mass (left)	0.3	1.1	4.0	0.6	1.3	-1.3	-2.0	-0.2	-1.1	0.6	0.3	0.5	0.9
Number of self-reported non-cancer illnesses	0.9	1.6	4.1	1.1	1.3	-1.6	-1.3	0.3	0.6	1.1	1.4	2.0	1.1
Average weekly champagne plus white wine intake	0.6	0.9	4.0	-0.7	-1.0	-0.2	2.0	-1.1	-0.6	0.2	-0.8	-0.4	-0.9
Miserableness	0.4	0.6	2.2	-0.0	-0.9	-0.7	0.4	-0.2	-0.6	-0.0	-1.5	0.8	-1.1
Guilty feelings	2.4	3.6	7.6	-1.9	-2.6	-2.7	0.7	0.5	1.3	-0.7	-2.5	1.5	-2.8
Wears glasses or contact lenses	0.8	1.0	3.2	-0.4	-1.2	0.3	1.3	-0.9	0.8	-0.0	-0.9	0.7	-1.8
Ever taken oral contraceptive pill	1.1	1.3	6.8	-0.4	-1.7	-1.0	-0.2	0.6	0.4	-0.5	-1.1	-0.2	-2.6
Hearing aid user	1.3	1.5	5.7	-1.2	-1.4	-0.6	0.6	-0.1	0.6	0.8	-2.4	1.9	-0.4
Mother’s age at death	0.5	0.6	2.6	-0.5	-0.0	1.6	1.6	0.3	0.1	0.5	0.5	-0.2	-0.2
Financial situation satisfaction	1.8	2.2	8.6	0.3	-0.1	-2.9	0.5	0.5	0.4	1.2	-1.1	2.8	-1.5
Tinnitus: Yes, now most or all of the time	0.9	1.1	4.5	-0.7	1.3	-0.4	0.6	0.6	0.5	1.7	0.4	2.1	0.5
Commuting to job workplace: Public transport	0.4	0.4	1.3	-0.2	-1.0	0.3	0.4	-0.8	-0.6	-0.3	-0.6	-1.1	-0.1
Eye problems/disorders: Glaucoma	0.8	1.0	3.4	-0.6	0.4	-1.8	1.8	-0.5	-0.5	-0.2	0.8	-0.5	1.2
Medication: Blood pressure	1.0	1.9	7.1	0.3	1.6	-1.5	-1.3	0.5	-0.4	2.1	0.5	2.7	0.9
Pain type(s) experienced in last month: Hip pain	0.5	0.6	3.1	0.4	-1.1	-1.8	0.6	-0.9	0.1	0.0	-0.3	0.4	-0.4
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.6	-0.4	1.6	0.8	-1.0	-1.1	-0.1	0.2	0.4	0.4	0.1
High cholesterol (Self-reported)	0.9	1.5	3.8	1.2	1.0	-0.5	1.3	0.5	1.7	1.5	0.9	1.9	-0.8
Medication: Bendroflumethiazide	1.0	1.5	4.5	1.1	1.0	-1.4	-2.1	-0.5	-0.7	0.7	0.9	0.2	2.0
Medication: Paracetamol	0.6	0.9	3.0	0.8	-1.4	-1.7	0.2	-1.0	-0.5	-0.9	0.1	0.0	-1.0
Medication: Lisinopril	0.4	0.5	1.4	0.7	0.6	0.9	-0.7	-1.2	0.1	0.0	0.8	0.1	0.9
Medication: Atorvastatin	0.5	0.7	2.4	0.2	1.0	0.8	-0.1	-0.9	0.2	1.2	0.1	1.5	-0.2
Illnesses of father: High blood pressure	0.5	0.7	1.7	-1.1	-0.9	-1.3	0.8	0.4	0.7	0.7	-0.2	0.6	-0.6
Alcohol drinker status: Never	0.8	1.0	3.7	-1.4	-0.7	-0.4	1.9	-0.3	1.3	-0.8	-0.2	-0.5	-1.0
Ever smoked	1.0	1.7	4.1	-1.7	-0.5	-1.4	2.0	1.1	1.4	1.1	-0.0	1.0	-1.6
Basal metabolic rate	0.2	1.1	6.4	-0.1	-0.1	-0.6	-1.4	0.2	0.2	-0.8	0.7	-0.8	2.5
Leg fat percentage (left)	0.6	2.3	6.2	1.7	2.4	-1.5	-2.5	0.1	-0.8	1.4	1.1	1.3	0.9
Arm fat-free mass (left)	0.3	1.6	9.7	-0.0	0.5	-0.7	-1.7	0.1	0.1	-0.7	1.1	-0.7	3.1
Number of operations (self-reported)	0.2	0.3	1.5	0.3	0.9	-0.3	-0.2	-1.2	0.0	-0.1	0.5	-0.1	0.2
Average weekly beer plus cider intake	2.3	3.4	11.8	0.6	3.4	-0.3	-0.9	2.0	1.2	2.3	1.7	1.5	2.1
Irritability	0.6	1.0	2.7	1.4	1.0	0.1	-1.1	-0.2	-1.6	0.2	-0.8	0.0	1.6
Risk taking	0.8	1.2	4.8	1.4	1.0	-0.4	-2.2	0.5	-1.8	0.7	0.5	-0.2	0.1
Ever had prostate specific antigen (PSA) test	0.8	0.9	3.4	1.8	0.3	0.8	-1.3	-1.2	0.1	-0.4	0.4	0.1	1.1
Fractured/broken bones in last 5 years	0.9	1.2	5.1	0.6	0.9	1.0	-1.3	-1.5	-2.3	-0.1	-0.7	-0.4	-0.3
Age started oral contraceptive pill	0.5	0.6	1.9	-0.1	0.8	0.4	-0.8	0.6	1.2	0.5	0.4	1.4	0.8
Diastolic blood pressure, automated reading	0.8	2.5	7.3	1.5	1.1	-2.6	-0.2	-0.7	-1.1	2.7	0.8	2.3	0.3
Ever depressed for a whole week	1.3	1.6	4.8	2.2	1.3	1.1	0.4	0.1	-0.5	-0.9	2.0	-1.7	0.4
Unable to work because of sickness or disability	1.0	1.2	3.2	-1.3	-0.6	-0.6	-0.7	1.3	-0.9	1.0	-1.8	1.0	-1.3
Commuting to job workplace: Cycle	0.7	0.8	1.8	-0.3	-1.0	0.3	0.3	-1.3	-1.0	-1.2	-1.4	-0.7	0.3
Myopia	0.4	0.6	2.4	-1.6	0.2	-0.5	-0.1	-0.5	0.9	0.9	-0.6	0.6	-0.8
Vascular/heart problems diagnosed by doctor	1.0	2.8	6.6	-0.0	-2.1	2.4	1.1	0.8	1.0	-2.6	-0.5	-2.5	-1.5
Cholesterol lowering medication	0.8	1.1	2.8	0.7	1.5	0.7	1.2	0.0	1.2	1.7	0.9	1.1	0.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.1	-0.9	-0.2	-0.2	-0.9	0.7	0.3	-1.0	-1.0	-1.0	-0.3
Pain experienced in last month	0.6	1.0	2.3	-0.4	-1.5	-0.3	1.5	1.1	0.7	-1.2	-0.7	-0.5	-1.3
Supplements: Calcium	0.9	1.0	4.4	-1.1	1.1	2.1	-1.1	-0.4	-0.4	1.0	0.4	-0.8	-0.2
Basal cell carcinoma (self-reported)	0.6	0.7	1.6	-1.2	-1.2	-0.8	-0.7	0.4	1.0	-0.9	-1.1	-0.0	-0.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.4	0.3	0.2	-0.5	-0.7	-0.3	0.2	0.8	-1.0	1.5	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.5	0.1	1.5	-0.3	-0.8	-0.9	0.3	0.2	1.2	-0.3	1.9
Heart disease (siblings)	2.5	3.1	11.0	1.7	2.6	0.2	0.3	0.9	0.0	3.3	1.7	2.5	0.2
Alcohol drinker status: Previous	0.6	0.7	2.4	0.0	-0.4	0.3	1.6	-0.7	1.4	0.8	0.1	1.0	-0.1
Pack years of smoking	1.0	1.4	3.3	1.4	1.8	0.3	-1.6	1.1	1.3	1.1	0.8	1.1	0.1
Impedance of whole body	0.0	0.2	1.6	0.0	-0.5	0.3	1.3	-0.4	0.2	0.2	0.2	-0.0	0.1
Leg fat mass (left)	0.5	1.8	6.3	1.2	2.0	-1.3	-2.5	0.0	-0.6	0.9	1.0	0.8	1.4
Arm predicted mass (left)	0.3	1.3	8.3	0.0	0.7	-0.8	-1.7	0.2	0.1	-0.3	1.0	-0.3	2.9