TWAS hub - SVIL

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.244	0.0583	1.2e-04	0.079	NA	0.115	NA	0.114	8.2e-07	NA	2.6e-09	NA	3.3e-09
2	GTEx	Brain Hypothalamus	0.414	0.1140	2.8e-03	-0.011	NA	-0.010	NA	-0.010	7.1e-01	NA	6.3e-01	NA	6.3e-01
3	GTEx	Cells Transformed fibroblasts	0.283	0.0520	2.1e-08	0.173	NA	0.160	NA	0.175	5.3e-13	NA	4.7e-12	NA	4.1e-13
4	GTEx	Thyroid	0.147	0.0560	5.7e-03	0.000	NA	0.020	NA	0.017	3.4e-01	NA	1.1e-02	NA	1.6e-02
5	GTEx	Whole Blood	0.132	0.0420	1.1e-03	0.042	NA	0.054	NA	0.054	8.6e-05	NA	1.0e-05	NA	1.1e-05
6	YFS	Blood	0.156	0.0221	0.0e+00	0.121	0.115	0.161	0.147	0.154	1.5e-37	1.0e-35	4.1e-50	9e-46	4.2e-48
7	TCGA	Thyroid Carcinoma	0.187	0.0460	3.5e-07	0.054	0.079	0.076	NA	0.024	5.8e-06	3.6e-08	7.2e-08	NA	2.0e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Migraine (self-reported)	4.7	5.9	23.8	4.9	1.4	-1.4	3.0	0.0	0.9	1.9
Pulse rate, automated reading	3.5	11.4	48.0	6.9	-0.9	2.2	3.5	1.2	0.6	3.5
Ever had hysterectomy (womb removed)	2.8	3.2	13.6	-0.5	3.7	-1.9	1.0	1.2	-1.6	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	2.8	6.4	11.6	-3.2	0.2	2.1	-3.4	-2.2	-3.4	-1.6
Pain all over the body in last month	2.6	2.8	7.1	-2.7	2.3	-0.0	-2.2	-0.9	-0.7	-1.0
Pulse rate	2.6	4.5	19.7	4.4	-0.5	0.7	1.8	0.1	-0.9	2.6
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.6	12.3	-3.5	0.6	2.2	-2.9	-1.2	-3.3	-0.7
Heart disease (siblings)	2.4	2.9	8.8	-0.6	1.6	0.5	-3.0	-1.6	-2.4	-0.5
Multivitamins +/- minerals	2.3	2.9	7.4	1.1	-0.0	-2.6	2.7	1.3	1.6	0.7
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	6.9	0.6	-2.3	2.6	0.1	-1.1	-2.1	-0.9
Pulse wave reflection index	2.3	2.8	14.3	-3.8	-0.1	0.5	-0.7	1.0	1.4	-1.2
Heel T-Score	2.1	16.7	34.8	-3.7	0.6	2.2	-5.2	-4.8	-5.9	-3.8
Mouth/teeth dental problems: Dentures	2.1	3.5	7.0	-1.7	2.3	0.6	-1.7	-0.8	-2.6	-2.4
Commuting to job workplace: Walk	2.1	2.3	3.3	-1.6	-1.5	1.7	-1.6	-1.5	-0.5	-1.8
Headache pain in last month	2.0	3.4	11.8	2.3	-0.4	0.7	0.9	3.4	2.3	0.3
High cholesterol (Self-reported)	2.0	3.6	8.9	-1.9	0.3	0.8	-2.7	-1.5	-3.0	-1.5
Major Depression (MDD)	1.9	2.3	9.2	0.1	-0.6	0.3	-3.0	0.1	-0.3	-2.4
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	6.8	-0.1	1.1	-1.7	1.4	2.6	1.1	1.0
Birth weight of first child	1.9	3.4	18.4	4.3	0.5	-1.0	1.6	-1.2	0.2	0.7
Medication: Ramipril	1.8	2.4	7.1	2.2	-1.0	-0.1	1.7	0.8	-0.0	2.7
Illnesses of siblings	1.8	2.5	5.5	-0.0	-1.9	-0.2	2.3	2.3	1.8	0.5
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	6.3	-0.1	-1.7	-2.0	-0.5	2.5	2.5	0.6
Medication: Atenolol	1.7	2.1	6.7	0.8	0.6	2.5	-0.1	-0.0	-2.6	0.8
Pulse wave peak to peak time	1.7	2.0	4.2	-1.6	1.0	-0.6	-2.0	-1.2	-2.1	0.2
Shortness of breath walking on level ground	1.6	1.9	6.1	-0.5	0.8	-1.1	-2.5	0.8	0.8	-2.0
Neuroticism (2016)	1.5	2.1	9.3	-3.0	1.7	0.1	-1.6	-0.2	0.2	-0.4
Type 2 Diabetes (T2D) (2018)	1.5	2.8	13.0	-1.5	0.3	0.8	-3.6	-0.0	-0.3	-1.8
Severe depression (siblings)	1.5	1.7	4.5	-0.8	-1.7	-0.1	-1.0	-2.1	-1.5	-0.5
Pulse wave Arterial Stiffness index	1.5	1.7	4.1	1.4	-0.9	0.4	2.0	1.1	2.0	-0.1
Medication: Paracetamol	1.5	2.5	5.8	2.4	-0.6	-1.2	0.4	1.7	2.3	1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.3	1.4	0.1	-1.7	0.9	1.8	1.4	0.4
Eye problems/disorders: Glaucoma	1.5	1.8	5.0	-1.2	-1.3	1.7	0.5	2.2	1.2	-0.0
Supplements: Fish oil (including cod liver oil)	1.5	2.0	6.9	0.3	1.3	-1.7	2.6	1.3	0.2	0.8
Frequency of depressed mood in last 2 weeks	1.4	1.9	5.5	-0.2	-0.0	-0.7	1.1	1.4	2.1	2.4
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	4.3	-0.5	2.0	0.8	-0.8	2.1	-0.6	-0.8
Medication: Seretide 50 evohaler	1.4	1.6	5.3	1.1	-0.2	1.1	-0.3	-2.3	-1.8	-0.6
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	3.9	1.3	-2.0	1.0	-0.5	-1.2	-1.8	-0.9
Illnesses of father: Heart disease	1.4	2.0	6.6	-0.7	-1.0	-2.6	-0.2	1.5	1.3	1.2
Illnesses of father: None of the above (group 1)	1.4	1.7	7.6	0.9	0.3	2.8	0.5	-1.4	-0.5	-1.0
Ever taken oral contraceptive pill	1.4	1.5	5.7	0.7	1.1	-0.5	-1.0	1.2	0.8	-2.4
Mother’s age at death	1.4	1.7	4.0	-1.4	1.6	0.3	-1.4	-0.1	-2.0	-1.3
Medication: Cholesterol lowering	1.3	2.0	7.5	-0.2	1.1	-0.2	-2.7	0.0	-1.3	-1.9
Mouth/teeth dental problems: Loose teeth	1.3	1.5	4.4	-2.1	-0.7	-1.1	0.7	1.4	1.5	0.2
Medication: Paracetamol	1.3	2.0	4.7	2.2	-0.3	-1.1	0.6	1.8	1.8	1.0
Bipolar Disorder (2018)	1.2	1.9	6.7	-0.2	-1.0	1.6	-1.5	-0.8	-0.5	-2.6
Alcohol usually taken with meals	1.2	2.0	4.7	-2.2	-1.8	0.9	-1.2	-1.8	-0.4	0.2
Exposure to tobacco smoke at home	1.2	1.3	6.4	0.0	-1.1	-1.0	0.7	-0.3	2.5	0.1
Number of full brothers	1.2	1.5	5.7	2.4	0.8	-1.3	-1.3	-0.1	-0.4	-0.9
Ever had bowel cancer screening	1.2	1.4	4.9	-0.7	1.3	0.5	-0.6	-0.9	-2.2	-1.1
Mineral and other dietary supplements	1.2	1.6	5.3	-1.1	-1.4	2.3	-1.3	-0.8	-0.4	0.3
Alzheimer’s Disease (in mother)	1.1	1.3	4.8	-0.8	-1.3	2.2	0.5	-1.2	0.6	-0.0
Lung FVC	1.1	5.6	13.3	-3.2	0.4	1.3	-2.6	-1.8	-1.9	-3.6
Supplements: Zinc	1.1	1.2	3.8	-0.7	1.1	-2.0	-0.4	-1.4	-0.9	-0.3
Maternal smoking around birth	1.1	1.6	6.8	-1.1	2.6	-0.6	-0.7	0.1	0.3	-1.6
Medication: Amlodipine	1.1	1.5	4.4	0.6	0.9	0.4	0.3	0.4	2.1	2.1
Health satisfaction	1.1	1.4	2.8	-1.3	-0.1	1.4	-1.7	1.2	1.2	-0.7
Illnesses of siblings: Diabetes	1.1	1.4	6.2	-1.4	0.4	-0.6	-2.5	-0.7	-0.1	-0.5
Guilty feelings	1.1	1.6	6.3	-0.9	-0.5	-2.5	0.8	-0.1	0.9	1.5
Medication: Bendroflumethiazide	1.1	1.7	4.8	-1.2	-2.2	-0.8	-1.3	-1.6	0.8	-0.7
Basal cell carcinoma (self-reported)	1.1	1.4	4.3	2.1	-0.7	-1.4	1.1	-0.9	-0.8	-0.5
Pack years of smoking	1.1	1.7	4.7	-1.9	-0.5	2.2	-0.5	-0.4	-1.1	-1.2
Schizophrenia (2018)	1.0	2.0	8.2	1.4	0.5	-1.3	2.9	0.4	-1.3	0.4
Mean Putamen Volume	1.0	1.2	2.9	0.3	-0.1	1.6	1.7	-0.2	-1.5	-0.5
Hearing difficulty/problems: Yes	1.0	1.5	3.2	-1.4	1.0	-1.5	-0.6	1.1	1.8	-0.4
Medication for hormone replacement therapy	1.0	1.2	4.4	0.6	1.4	1.0	-0.0	2.1	-0.3	-0.6
Diabetes (father)	1.0	1.3	7.1	0.7	-0.3	-2.7	0.9	0.7	0.2	0.1
Pack years adult smoking proportion	1.0	1.6	4.0	-1.9	-0.9	2.0	-0.7	-0.7	-0.5	-1.2
Average weekly fortified wine intake	1.0	1.2	3.2	0.5	-1.1	-1.0	-0.5	1.2	1.8	-0.9
Age when periods started (menarche)	1.0	2.4	6.2	0.4	-1.9	0.1	-1.6	-1.8	-2.5	-0.8
Supplements: Glucosamine	1.0	1.3	3.1	0.1	1.1	-1.5	0.4	1.8	1.4	0.3
Number of incorrect matches in round	1.0	1.7	3.8	-0.3	-0.1	0.3	0.9	-1.9	-1.8	1.9
Nervous feelings	1.0	1.8	5.2	0.3	-1.8	-2.3	-0.2	-0.8	1.4	1.1
Financial difficulties in last 2 years	1.0	1.3	4.3	-1.1	2.1	-1.5	-0.0	0.2	1.2	0.1
Mouth/teeth dental problems	1.0	1.6	4.3	1.2	-1.2	-0.7	1.1	0.8	1.2	2.1
Diabetes (self-reported)	1.0	1.5	4.1	-1.5	0.0	-0.4	-2.0	1.4	0.8	-1.3
Noisy workplace	1.0	1.2	3.4	-1.1	1.8	0.4	0.1	1.8	0.4	-0.6
Birth weight	1.0	2.1	12.5	3.5	-0.7	-0.7	1.1	0.1	0.1	0.4
Wheeze or whistling in the chest in last year	1.0	1.8	4.8	-1.1	1.1	1.1	0.6	0.7	-2.2	1.7
Eye problems/disorders: None of the above	1.0	1.2	2.6	1.6	-1.1	-1.6	0.7	-1.2	-0.0	0.4
Neck or shoulder pain in last month	1.0	1.4	4.2	-0.4	-0.3	1.6	-0.5	1.1	-1.3	2.0
Medication: Omeprazole	1.0	1.2	3.3	-1.8	-0.6	1.6	-0.7	-1.0	-0.3	-0.6
Suffer from ‘nerves’	1.0	1.6	5.4	-0.7	-1.0	-2.3	-0.4	-0.7	2.0	-0.1
Leg pain on walking	1.0	1.3	2.9	0.3	1.3	0.6	1.4	1.7	1.4	0.5
Relative age voice broke	0.9	1.3	4.0	-0.9	0.0	2.0	-0.4	0.7	-2.0	-0.3
Hayfever, allergic rhinitis or eczema	0.9	2.0	3.7	-1.9	-1.8	1.1	0.5	1.6	1.8	0.2
Medication: Levothyroxine sodium	0.9	1.4	2.4	0.4	-1.2	-1.3	-1.3	1.1	1.2	-1.6
Hair/balding pattern: Pattern 2	0.9	1.1	4.6	-2.1	0.9	-0.1	-0.5	0.1	1.2	-0.8
Medication: Simvastatin	0.9	1.3	4.5	-0.2	1.0	-0.6	-2.1	-1.0	-0.9	-1.2
Lung cancer (father)	0.9	1.0	2.4	1.1	1.1	-0.1	0.3	1.5	-1.5	0.3
Chest pain or discomfort	0.9	1.3	6.7	0.3	-0.5	-2.6	-0.0	-1.1	0.8	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.5	-0.3	-1.9	1.0	0.6	0.9	-0.5	-1.2
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.9	0.6	1.7	0.9	-0.6	0.1	-1.1	1.3
Smoking status: Previous	0.9	1.3	4.8	0.3	0.9	0.2	-2.2	-0.9	-1.4	-0.9
Friendships satisfaction	0.9	1.1	4.7	-0.9	-0.9	2.2	-0.8	-0.8	0.1	0.3
Average weekly champagne plus white wine intake	0.9	1.2	5.4	0.7	0.9	-0.5	1.1	0.5	-0.2	2.3
Diastolic blood pressure, automated reading	0.9	2.7	7.2	2.7	0.7	0.6	1.8	1.5	-0.6	2.2
Unable to work because of sickness or disability	0.9	1.1	3.1	-1.7	-0.5	0.3	-0.1	1.0	1.4	1.3
Alcohol drinker status: Previous	0.9	1.1	4.5	-0.8	0.4	-0.2	1.1	0.9	0.1	2.1
Prostate Cancer	0.8	1.1	3.9	-0.6	0.3	1.2	0.0	1.4	2.0	0.0
HbA1C	0.8	0.9	1.9	0.3	-0.8	-1.4	1.3	0.5	0.4	-1.2
Blood White Count	0.8	5.8	21.7	-4.7	1.9	-0.7	-2.7	-0.8	-1.2	-2.4
Average weekly spirits intake	0.8	1.0	5.4	-2.3	0.1	-0.7	-0.2	-0.1	0.3	-0.8
Medication: Co-codamol	0.8	1.0	2.5	-1.2	-0.2	1.3	-0.1	-1.0	-0.4	1.6
Past tobacco smoking	0.8	1.5	5.5	0.3	-1.2	-0.4	2.3	1.1	0.7	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.2	0.8	0.6	1.5	1.1	0.8	0.9	0.9
Medication: Lansoprazole	0.8	1.0	2.8	1.0	-1.7	0.5	0.5	-1.1	-1.1	0.4
Breastfed as a baby	0.8	1.0	3.1	-0.3	1.0	1.7	-0.2	1.8	0.3	-0.2
Loud music exposure frequency	0.8	0.8	2.0	-1.1	1.4	-0.5	0.0	1.3	0.9	-0.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	3.6	-0.3	-1.6	0.0	1.9	-0.0	1.2	1.3
Glaucoma (self-reported)	0.8	1.0	3.1	-1.2	-0.4	0.5	-0.9	1.8	0.5	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	4.5	-1.3	0.3	-0.4	-2.1	-0.5	0.8	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.4	-1.5	0.4	0.6	-0.4	1.3	-0.9	0.9
Age at first live birth	0.8	1.4	5.8	-0.1	-0.6	-0.2	-1.0	0.6	2.4	-1.5
Medication for pain relief, constipation, heartburn	0.8	1.4	4.5	-0.9	-0.3	0.4	0.1	-1.4	-2.1	-1.4
Age at last live birth	0.8	1.2	4.8	-0.3	-1.3	-0.1	-1.1	-0.2	2.2	-0.8
Family relationship satisfaction	0.8	1.0	2.8	1.7	-0.2	0.3	-0.7	-0.2	1.5	-1.0
Back pain experienced in last month	0.8	1.1	2.2	-1.1	0.1	0.9	-1.5	-1.4	-1.3	-0.3
Osteoarthritis (self-reported)	0.8	1.0	3.0	1.4	0.8	1.0	-1.7	0.2	0.2	0.5
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.5	0.5	-0.3	0.7	-1.0	-1.9	-1.4	-0.2
Irritability	0.8	1.4	4.0	-1.3	0.5	2.0	-1.3	0.2	-0.4	1.3
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.7	1.3	0.3	-1.0	1.2	1.2	0.9	0.3
Fractured/broken bones in last 5 years	0.8	1.0	2.9	1.0	-0.1	-0.9	1.1	-1.7	-1.0	-0.5
Alzheimer’s Disease (in father)	0.7	0.7	2.4	-1.4	0.6	0.5	-0.3	1.6	0.2	0.6
Alzheimer’s Disease (including proxy)	0.7	1.0	4.9	-1.0	-0.6	2.2	-0.4	0.0	0.3	-0.8
Ovarian Cancer	0.7	1.0	3.5	1.9	0.4	-0.6	1.2	0.1	1.2	0.1
Crohns Disease (2012)	0.7	1.1	3.1	-0.1	-1.4	1.3	0.0	-1.7	-0.9	0.6
Fasting Glucose	0.7	0.8	4.7	0.6	-2.2	-0.2	0.2	-0.1	0.6	-0.6
Primary Biliary Cirrhosis	0.7	1.1	3.3	1.8	0.4	-1.2	-1.1	0.0	1.1	-0.2
Allergy or Eczema	0.7	1.8	3.8	-1.5	-1.4	1.0	0.7	2.0	1.3	-1.3
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.1	-0.8	0.1	0.9	-1.4	0.1	-1.1	-1.2
Vitamin and mineral supplements	0.7	1.0	3.7	-0.8	0.5	1.9	-1.0	-1.2	-0.3	0.2
Medication: Metformin	0.7	0.9	3.0	-1.1	-0.8	-0.2	-1.7	-0.3	-0.5	-1.1
Time employed in main current job	0.7	0.8	3.0	1.7	-1.4	0.0	0.0	0.3	-0.2	-0.5
Number of live births	0.7	0.9	4.0	-0.6	0.1	0.9	0.3	0.1	-2.0	1.1
Ever highly irritable/argumentative for 2 days	0.7	0.9	3.1	-1.2	0.5	0.3	-0.8	1.8	-0.4	-0.5
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.6	0.6	1.2	0.6	0.1	1.9	-0.7	0.3
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.2	-0.9	0.4	-1.5	0.3	0.4	1.4	0.6
Emphysema/chronic bronchitis	0.7	0.8	2.9	0.6	1.3	1.7	-0.0	0.3	-0.1	-0.4
Heart disease (mother)	0.7	0.9	2.6	1.6	1.0	-0.7	0.4	-0.2	0.1	-1.4
Had major operations	0.7	0.8	2.3	-0.6	0.7	-0.3	-0.9	0.9	1.5	-1.1
Knee pain experienced in last month	0.7	1.1	3.7	-0.7	1.0	1.9	-0.4	0.9	1.2	0.0
Mood swings	0.7	1.3	3.4	-1.9	-1.8	0.0	-0.6	-0.2	-0.2	1.4
Diabetes diagnosed by doctor	0.7	1.1	5.4	-1.3	-0.1	0.1	-2.3	0.6	0.0	-0.5
Miserableness	0.7	1.1	1.9	-1.3	1.3	-0.9	-0.3	0.1	1.3	1.4
Tinnitus: Yes, now most or all of the time	0.7	0.8	4.2	0.0	0.3	-0.5	-0.4	-0.3	0.9	-2.1
Commuting to job workplace: Public transport	0.7	0.8	1.9	-0.8	-1.2	0.8	0.1	-0.8	-0.5	-1.4
Alcohol drinker status: Never	0.7	0.9	3.7	-0.2	-1.3	1.9	-0.0	-0.5	0.6	0.0
Risk taking	0.7	1.1	2.8	0.7	1.1	1.7	0.2	0.8	1.4	-0.5
Commuting to job workplace: Cycle	0.7	0.9	4.0	-0.7	1.0	-0.3	-0.0	0.2	2.0	0.9
Cholesterol lowering medication	0.7	1.0	3.0	-1.6	-0.5	0.4	-0.7	-1.7	-0.9	0.3
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	3.8	-0.7	-0.4	1.9	0.1	-0.9	-0.9	-0.4
Depressed Affect (Nagel 2018)	0.6	1.3	5.0	-2.2	-0.2	-0.1	-1.4	-1.1	-0.2	0.9
Ulcerative Colitis (UC)	0.6	1.2	4.4	-0.5	0.9	2.1	0.6	0.8	-0.3	1.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	3.4	-0.4	0.5	1.8	-0.0	-0.8	-0.7	-0.2
Sensitivity / hurt feelings	0.6	1.1	2.7	-1.2	0.6	-0.7	0.7	1.6	0.1	1.5
Relative age of first facial hair	0.6	1.3	2.8	-1.1	1.1	1.1	-1.5	-0.1	-1.7	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	3.0	-0.5	-1.7	-0.5	0.1	-0.6	1.1	0.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.1	0.6	-0.9	0.5	0.1	0.7	1.1	-1.0
Had other major operations	0.6	0.8	2.0	0.6	0.6	1.4	0.4	-0.7	-1.4	-0.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.9	-0.9	0.2	-0.6	-0.6	1.7	-0.1	0.9
Neuroticism score	0.6	1.3	3.6	-1.9	-0.5	-1.1	-0.0	-0.3	0.4	1.9
Alcohol intake versus 10 years previously	0.6	0.9	4.0	-0.6	-0.2	-2.0	1.0	0.9	0.5	-0.4
Hair/balding pattern: Pattern 3	0.6	0.9	4.2	2.1	0.2	-1.1	-0.8	-0.3	0.4	0.4
Depression (self-reported)	0.6	0.7	1.7	0.4	-0.1	-0.2	-1.2	-1.1	-0.6	1.3
Hair/balding pattern: Pattern 4	0.6	1.6	5.6	-0.5	-1.8	-0.9	2.4	0.8	-0.7	0.2
High blood pressure (siblings)	0.6	0.9	3.4	-0.1	1.8	-0.2	-1.5	-0.6	-0.4	-0.2
Worry too long after embarrassment	0.6	1.0	1.9	0.4	-0.8	-1.3	1.4	0.1	0.9	1.3
Average weekly red wine intake	0.6	0.9	2.6	0.6	-0.0	0.5	1.4	-0.5	-0.7	1.6
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.7	1.6	0.3	0.9	0.2	-0.1	-0.7	-1.0
Osteoporosis (self-reported)	0.6	0.8	1.7	1.0	0.7	-1.3	0.9	0.9	-0.6	0.7
Medication: Gliclazide	0.6	0.6	1.7	-0.6	-1.3	0.1	0.4	-0.1	0.9	1.2
Hearing aid user	0.6	0.7	2.4	-0.2	1.6	0.4	-1.0	-0.5	0.7	-0.4
Financial situation satisfaction	0.6	0.7	2.1	0.8	0.3	-0.1	-0.4	-1.1	0.8	-1.4
Illnesses of father: High blood pressure	0.6	0.8	1.7	-1.1	-0.1	1.3	-1.0	-0.6	-0.2	1.0
Ever smoked	0.6	1.1	2.9	-0.1	1.1	0.3	-1.7	-1.2	-0.8	-1.1
Myopia	0.6	0.8	3.3	-0.6	0.1	0.8	-0.9	-0.4	-1.8	-0.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.4	1.1	-0.4	1.6	0.9	0.6	0.6	0.3
Depression (Nagel 2018)	0.5	0.8	2.7	0.3	0.1	-0.9	0.0	1.2	1.6	0.6
Neuroticism (Nagel 2018)	0.5	1.1	3.4	-1.8	-1.1	-0.4	-0.8	-0.7	0.6	1.2
Crohns Disease (2017)	0.5	1.0	3.5	-0.7	-0.9	0.7	-0.5	-1.9	-1.2	0.5
Breast Cancer	0.5	1.3	5.9	-0.2	0.1	0.3	1.0	2.4	1.2	0.6
Bipolar Disorder (2011)	0.5	0.5	1.5	0.8	0.2	-1.2	-0.2	0.3	-0.9	-0.4
Coronary Artery Disease (CAD)	0.5	0.5	1.6	0.8	1.0	-0.1	-0.6	-1.3	-0.1	-0.4
LDL Cholesterol	0.5	0.8	2.2	0.5	0.5	-0.2	1.1	-0.2	-1.5	1.2
Lupus	0.5	0.7	2.3	0.8	1.5	0.2	0.9	-0.2	-1.0	0.5
Triglycerides	0.5	0.8	1.6	0.8	-1.3	1.1	0.3	-1.3	-0.1	0.5
Hand grip strength (left)	0.5	1.2	6.0	0.2	-0.4	2.4	-1.1	-0.7	-0.6	0.6
Townsend deprivation index at recruitment	0.5	0.8	2.7	-0.0	-1.1	-0.0	0.1	-1.6	0.9	-0.8
Fed-up feelings	0.5	0.9	2.7	-1.6	-0.9	-0.3	0.4	-0.6	0.3	1.6
Qualifications: CSEs or equivalent	0.5	0.7	2.0	0.8	-0.2	-1.3	0.8	0.1	1.4	0.0
Serious illness, injury or assault to yourself	0.5	0.6	2.3	1.0	-0.4	-0.3	0.3	0.6	1.5	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	3.3	0.8	-0.9	-0.6	0.7	0.2	0.2	1.8
Had menopause	0.5	0.7	1.7	0.9	0.2	0.8	0.6	-0.9	-1.3	-0.5
Allergy	0.5	1.1	3.1	1.3	1.7	-1.3	-0.2	-1.0	-0.6	-0.3
Impedance of arm (right)	0.5	2.4	5.7	-1.5	-1.0	-1.8	1.8	1.0	-2.4	0.7
Happiness	0.5	0.6	2.0	1.4	0.1	-0.3	0.9	1.0	0.3	0.7
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.1	-0.3	1.4	0.9	0.4	1.8	-0.1	0.9
Impedance of arm (left)	0.5	2.5	4.1	-2.0	-0.8	-1.8	1.8	0.9	-2.0	1.2
Length of working week for main job	0.5	0.5	1.5	-1.2	-0.7	-0.0	0.2	-1.1	0.7	-0.3
Tense / ‘highly strung’	0.5	0.9	1.8	-0.8	-1.0	1.1	-0.5	-0.5	-1.0	1.3
Gout (self-reported)	0.5	0.7	1.7	-0.7	-1.1	0.8	-1.3	0.7	0.5	0.2
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.8	0.6	-0.4	-1.9	-1.3	0.4	0.7	-0.5
Comparative body size at age 10	0.5	1.4	4.3	-1.2	0.1	1.4	-1.5	0.4	2.1	0.1
Medication: Ibuprofen	0.5	0.6	2.0	0.6	-0.0	0.3	0.7	0.1	1.4	1.1
Medication: Allopurinol	0.5	0.6	1.4	-0.4	-0.9	1.2	-0.4	1.1	-0.3	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.4	0.1	-0.6	-0.0	0.7	1.5	0.6	0.9
Loneliness, isolation	0.5	0.6	2.0	-1.4	-0.2	-0.6	-0.8	-0.9	0.0	0.8
Medication for cholesterol	0.5	0.7	1.9	1.4	-0.4	-1.4	0.7	-0.3	-0.4	-0.5
Average weekly beer plus cider intake	0.5	0.8	2.1	-0.2	1.4	1.2	-0.7	1.1	0.2	-0.3
Age started oral contraceptive pill	0.5	0.7	1.8	0.5	-0.7	1.4	0.7	0.1	-0.7	-1.1
Ever depressed for a whole week	0.5	0.6	1.8	1.1	-1.3	0.7	-0.2	-0.1	0.6	-0.6
Pain experienced in last month	0.5	0.8	2.4	-0.6	-1.1	-1.1	0.0	-0.8	-0.0	-1.6
Bipolar Disorder or Schizophrenia	0.4	0.9	1.8	1.0	-0.3	-0.0	1.3	-0.2	-1.3	-1.3
Worry (Nagel 2018)	0.4	0.9	1.7	-0.9	-1.3	-0.3	-1.1	-1.2	0.6	0.7
Irritable Bowel Disease (IBD)	0.4	0.9	3.3	-0.9	0.3	1.8	-0.4	-0.4	-1.0	1.0
Reaction Time	0.4	0.7	2.9	0.8	-0.3	-0.8	0.1	1.7	0.6	-0.5
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.7	-0.8	0.6	-0.7	-0.6	-1.1	1.0	-1.6
Age at First Birth	0.4	0.6	1.6	-0.1	-0.9	0.3	-0.5	0.4	1.3	-1.0
HDL Cholesterol	0.4	0.7	2.7	-0.8	0.1	0.6	0.4	1.6	0.6	0.7
Ulcerative Colitis	0.4	0.6	1.1	-0.8	0.9	1.1	0.6	0.8	-0.4	0.6
Blood Eosinophil Count	0.4	3.0	12.2	-1.9	-0.3	0.9	-1.8	-0.6	-3.5	-0.8
Blood Platelet Count	0.4	4.8	20.2	-4.5	0.8	1.6	-2.8	-1.0	-0.8	-0.9
Hypothyroidism (self reported)	0.4	1.0	4.5	-0.0	0.3	-2.1	-0.8	0.3	1.2	0.5
Lung FEV1/FVC ratio	0.4	2.0	6.1	2.2	-2.5	0.0	0.4	-1.3	1.0	0.6
Neuroticism	0.4	1.0	3.7	-1.9	-0.8	-0.5	-1.2	-0.8	0.5	0.5
Chronotype (morning person)	0.4	0.9	2.3	1.5	0.7	0.7	1.1	0.4	-0.7	-0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	-0.7	0.7	-0.9	-0.2	0.8	1.0	0.2
Systolic blood pressure, automated reading	0.4	1.3	3.4	0.0	1.9	0.8	-1.5	0.2	-1.0	-1.4
Trunk fat percentage	0.4	1.8	4.7	-1.6	2.2	-1.1	-0.1	1.1	-1.5	0.4
Hand grip strength (right)	0.4	1.1	2.6	-0.5	-0.9	1.6	-1.3	-0.8	-1.0	0.8
Chronic bronchitis/emphysema (father)	0.4	0.5	2.2	-0.6	-0.1	-1.5	-0.4	-0.7	-0.1	-0.1
High blood pressure (mother)	0.4	0.6	2.9	0.2	0.8	1.7	0.1	0.5	0.1	0.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.4	-0.6	0.6	0.7	-1.2	-0.7	0.2	-0.4
Heart attack	0.4	0.5	1.9	1.0	-0.2	1.4	0.6	0.4	0.4	0.2
Fluid intelligence score	0.4	0.8	2.4	-1.4	0.7	0.7	0.0	-0.0	1.5	-0.7
Father’s age at death	0.4	0.5	0.9	0.8	0.2	0.8	0.8	0.9	0.8	0.3
Asthma	0.4	0.8	2.3	-0.2	0.6	-0.5	0.6	1.4	-0.4	1.5
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.5	0.1	0.7	0.3	-1.1	-0.3	1.2	-0.2
Prospective memory result	0.4	0.5	0.9	0.9	-0.4	-0.5	-0.6	-0.6	-0.7	0.9
Illnesses of mother	0.4	0.5	2.2	-0.4	0.7	-1.5	-0.6	-0.3	-0.5	0.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.3	1.1	0.6	1.0	0.4	0.7	0.6	0.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	2.2	0.1	-0.5	-0.9	0.2	-1.5	0.4	-0.6
Blood clot in the leg (DVT)	0.4	0.5	1.0	-0.7	-0.2	-0.8	-1.0	-1.0	-0.5	-0.2
Body fat percentage	0.4	1.5	4.2	-1.7	2.0	-0.7	-0.4	1.0	-1.4	0.0
Angina (self-reported)	0.4	0.5	1.3	1.1	-0.5	0.3	0.6	-0.0	1.0	-0.5
Mean time to correctly identify matches	0.4	0.9	2.7	0.2	-0.1	-1.2	0.2	1.6	0.5	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.6	1.1	-0.9	1.0	-0.4	-0.3	-1.3	0.9
Qualifications: nursing, teaching	0.4	0.6	1.9	0.1	-0.0	1.4	-0.4	1.2	0.9	-0.0
Eye problems/disorders: Cataract	0.4	0.5	1.0	-0.6	1.0	0.1	0.5	0.6	-0.8	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.9	-0.9	0.5	-0.6	-0.9	0.7	-0.1	-0.5
Asthma (self-reported)	0.4	0.8	3.3	0.4	0.4	-0.4	0.7	1.1	-0.5	1.8
Smoking status: Current	0.4	0.6	2.5	-0.6	0.8	0.5	-0.2	0.3	1.6	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.6	1.0	-1.4	-0.5	-0.1	-0.1	0.4	-1.6
Number of self-reported non-cancer illnesses	0.4	0.7	2.5	-0.6	0.8	-0.5	-1.6	0.5	-0.7	0.5
Medication: Blood pressure	0.4	0.7	2.2	-0.5	-0.3	0.4	0.5	-1.3	0.3	1.5
Medication: Atorvastatin	0.4	0.5	1.3	0.3	-0.2	1.2	-0.9	-0.6	0.3	-0.9
Number of operations (self-reported)	0.4	0.7	2.0	-0.1	0.9	0.1	-1.4	-0.5	-0.3	-1.3
Supplements: Calcium	0.4	0.4	2.3	-1.5	0.3	0.2	-0.4	0.4	-0.4	0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	-0.8	-0.3	-0.7	-1.1	-0.8	-0.4	-0.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	4.1	0.6	-0.4	-0.4	0.5	1.0	2.0	-0.7
Smoking Status	0.3	0.7	1.5	0.1	0.9	0.8	-0.9	-1.2	-0.0	-1.2
Cardiovascular Disease	0.3	1.1	4.1	-0.2	1.6	-0.0	-2.0	-0.5	-0.8	0.5
Number of treatments/medications taken	0.3	0.5	1.7	-0.4	0.1	0.2	-1.0	1.3	-0.2	0.8
Angina	0.3	0.4	0.9	0.9	-0.7	0.3	0.6	0.1	0.8	-0.7
Current tobacco smoking	0.3	0.5	1.7	-0.9	0.6	0.5	-0.5	-0.1	1.3	-0.5
Taking other prescription medications	0.3	0.4	1.4	0.5	-0.3	-0.0	0.4	0.3	-1.2	0.9
Stomach or abdominal pain in last month	0.3	0.4	0.9	0.1	0.9	0.4	-0.0	-1.0	-0.7	0.6
Sitting height	0.3	1.8	5.9	0.3	0.4	0.2	-1.2	-2.4	-2.1	0.6
Hearing difficulty/problems with background noise	0.3	0.5	1.3	0.3	0.0	-1.2	-0.1	1.0	0.8	-0.7
Arm fat percentage (right)	0.3	1.2	3.3	-1.7	1.8	-0.9	-0.2	0.8	-0.8	-0.3
Worrier / anxious feelings	0.3	0.6	2.3	-0.7	-1.5	0.8	-0.4	-0.6	0.4	0.1
Falls in the last year	0.3	0.4	1.6	0.0	0.3	0.1	0.8	0.0	0.5	1.3
Leg fat percentage (right)	0.3	1.0	2.8	-0.4	1.2	0.3	-1.7	0.2	-0.8	-1.3
Exposure to tobacco smoke outside home	0.3	0.4	0.6	0.6	0.8	0.8	0.0	0.8	0.8	-0.6
Number of children fathered	0.3	0.4	1.2	0.3	-0.5	0.2	-1.1	-0.8	-0.1	-0.6
Alcohol intake frequency.	0.3	0.8	3.6	-0.0	-0.4	-0.2	1.3	0.1	0.1	1.9
Comparative height size at age 10	0.3	1.8	5.9	-1.0	-2.4	-1.6	0.0	-0.1	1.6	-0.4
Supplements: Vitamin C	0.3	0.4	1.1	-0.7	-0.3	-0.1	-1.1	0.2	-0.9	-0.7
Arm fat percentage (left)	0.3	1.3	4.1	-2.0	1.8	-0.9	-0.2	0.9	-0.6	-0.0
Breast cancer (self-reported)	0.3	0.4	1.6	-0.5	0.1	-0.3	-0.8	-1.3	-0.1	0.0
Medication: Aspirin	0.3	0.5	1.3	0.9	-1.1	-0.3	-0.2	-0.3	0.9	-0.0
Wears glasses or contact lenses	0.3	0.4	1.6	0.0	-0.3	0.4	-1.3	0.8	-0.3	0.1
Medication: Lisinopril	0.3	0.4	1.3	0.5	0.8	-0.4	1.1	-0.1	0.5	-0.1
Leg fat percentage (left)	0.3	1.0	2.1	-0.4	1.4	0.3	-1.4	0.1	-0.8	-1.4
Impedance of whole body	0.3	1.6	4.5	-1.4	-0.9	-1.3	1.1	0.7	-2.1	0.6
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	-0.8	0.1	0.7	0.7	0.5	-0.3	0.3
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	-0.1	0.3	-0.4	-0.9	-0.7	-0.5	-0.7
Rheumatoid Arthritis	0.2	0.3	0.8	-0.1	-0.6	-0.5	-0.9	0.6	-0.8	-0.1
Schizophrenia (2014)	0.2	0.5	1.0	0.1	-0.4	-0.9	1.0	0.0	-0.8	-0.7
Blood Red Count	0.2	1.9	9.7	-3.1	1.3	-0.3	-1.0	0.0	-0.5	-0.7
BMI	0.2	1.1	7.1	0.1	2.7	0.6	-0.1	0.5	0.1	-0.1
Waist Hip Ratio (WHR)	0.2	0.9	4.2	-0.2	-1.0	0.2	-2.0	-0.4	-0.9	-0.6
Systolic Blood Pressure	0.2	0.9	2.7	-0.7	1.4	0.7	-1.6	0.1	-0.2	-1.0
Respiratory disease	0.2	0.4	0.8	-0.3	0.9	0.6	0.4	0.8	-0.9	0.1
Impedance of leg (right)	0.2	0.9	4.0	-0.5	-1.2	0.1	-0.5	0.4	-2.0	-0.6
High blood pressure	0.2	0.6	1.6	-0.6	0.0	-0.8	-1.3	0.6	0.6	1.1
Body mass index (BMI)	0.2	0.7	3.6	-0.4	1.9	0.2	-0.9	0.4	0.0	-0.5
Impedance of leg (left)	0.2	1.2	6.3	-0.5	-0.9	0.1	-0.1	0.2	-2.5	-0.9
Trunk fat mass	0.2	1.0	2.8	-1.1	1.7	-0.9	-0.4	0.7	-1.0	0.3
Waist circumference	0.2	0.7	3.3	-0.5	0.6	-0.3	-1.8	-0.5	-0.8	-0.1
Forced vital capacity (FVC)	0.2	0.7	1.7	-0.8	0.2	0.5	-0.9	-1.2	-1.3	-0.1
Qualifications: None of the above	0.2	0.5	1.8	0.1	1.4	-1.0	0.6	0.6	-0.3	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.7	1.0	-1.3	-0.1	-0.5	-1.3	-0.1	0.1
Trunk predicted mass	0.2	0.9	2.5	0.8	-0.7	-0.0	-1.6	-0.7	1.4	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.3	-0.7	-0.2	-0.1	-0.6	-0.4	-0.4	1.2
Peak expiratory flow (PEF)	0.2	0.4	1.1	-0.7	1.1	-0.4	-0.3	-0.3	0.4	-0.9
Forced vital capacity (FVC), Best measure	0.2	0.8	2.4	0.4	-0.0	0.9	-1.1	-1.6	-1.2	-0.2
Medication: Blood pressure	0.2	0.4	0.6	0.4	0.8	-0.7	-0.5	0.5	-0.4	0.8
Whole body fat mass	0.2	0.9	3.1	-1.1	1.8	-0.6	-0.8	0.7	-0.8	0.3
Number of full sisters	0.2	0.2	1.2	-0.1	0.4	0.1	0.1	-0.1	1.1	-0.4
Overall health rating	0.2	0.5	2.3	0.3	-0.4	0.6	-0.4	-0.1	1.5	-0.2
Medication: Aspirin	0.2	0.3	1.1	0.4	-1.0	-0.4	-0.3	0.1	0.8	-0.1
Hypertension (Self-reported)	0.2	0.5	1.7	-0.5	-0.3	-0.1	-1.3	0.7	0.1	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.6	-0.7	-0.2	0.2	-0.4	-0.5	-0.7	0.3
Long-standing illness, disability or infirmity	0.2	0.3	1.0	-0.1	1.0	0.1	0.3	0.6	0.4	0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.6	0.5	0.2	1.3	0.4	0.4	-0.4	-0.3
Arm fat mass (left)	0.2	0.7	2.2	-1.1	1.5	-0.9	-0.4	0.7	-0.2	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.5	2.3	-0.0	-0.6	0.3	1.5	-0.5	-0.8	-0.2
Leg fat mass (left)	0.2	0.6	2.3	-0.2	1.5	0.0	-1.2	0.2	-0.3	-0.7
Height	0.1	2.6	6.1	2.0	-2.5	-2.5	-1.0	0.1	0.6	0.7
Tanning	0.1	1.1	4.7	1.0	0.7	0.8	0.6	2.2	0.0	-0.4
Diabetes (mother)	0.1	0.1	0.4	-0.2	0.2	-0.0	-0.0	-0.1	-0.6	-0.7
Leg fat-free mass (left)	0.1	0.7	2.3	0.3	0.7	-0.7	-0.4	-0.2	1.2	1.5
Leg predicted mass (left)	0.1	0.7	2.4	0.4	0.6	-0.8	-0.4	-0.3	1.1	1.5
Weight	0.1	0.3	1.1	-0.2	1.0	-0.4	-0.9	-0.1	-0.3	0.4
Trunk fat-free mass	0.1	0.8	2.2	0.8	-0.6	0.0	-1.5	-0.7	1.4	-0.1
Hip circumference	0.1	0.3	0.9	-0.0	0.9	-0.9	-0.6	0.1	-0.4	0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.0	-0.5	-0.8	-0.1	-0.4	-1.0	-0.7	-0.0
Arm fat mass (right)	0.1	0.6	2.3	-1.0	1.5	-0.7	-0.2	0.7	-0.3	0.3
Standing height	0.1	1.4	3.8	0.6	-1.6	-1.3	-0.2	-1.0	-0.8	1.9
Arm fat-free mass (right)	0.1	0.7	1.9	1.0	0.0	-0.0	-1.2	-0.3	1.4	0.7
Qualifications: College or University degree	0.1	0.4	1.6	0.2	0.4	0.5	0.6	1.3	0.5	0.3
Leg fat mass (right)	0.1	0.6	1.9	-0.2	1.4	-0.0	-1.2	0.4	-0.3	-0.4
Arm predicted mass (right)	0.1	0.7	2.3	0.7	0.1	-0.0	-1.2	-0.2	1.5	0.7
Whole body fat-free mass	0.1	0.5	1.6	0.7	0.0	-0.2	-0.9	-0.5	1.2	0.7
Leg fat-free mass (right)	0.1	0.6	2.0	0.3	0.6	-0.8	-0.2	-0.4	1.1	1.4
Whole body water mass	0.1	0.5	1.7	0.6	0.0	-0.2	-0.8	-0.5	1.3	0.7
Leg predicted mass (right)	0.1	0.6	2.1	0.4	0.6	-0.9	-0.1	-0.4	1.0	1.4
Basal metabolic rate	0.1	0.4	1.0	0.6	0.3	-0.4	-0.9	-0.4	1.0	0.8
Arm fat-free mass (left)	0.1	0.5	1.8	0.7	0.4	0.1	-1.3	-0.4	1.1	0.1
Arm predicted mass (left)	0.1	0.7	2.2	1.0	0.4	0.3	-1.1	0.1	1.5	0.1
Hair Pigment	0.0	0.8	1.8	-1.3	0.1	-0.3	-0.2	-1.0	-1.3	1.0

Hub : Genes

SVIL

Models

Trait associations