TWAS hub - YME1L1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.1220	0.0570	6.2e-03	0.005	NA	-0.005	NA	0.011	2.2e-01	NA	5.0e-01	NA	1.4e-01
2	METSIM	Adipose	0.0478	0.0180	2.5e-05	0.025	0.024	0.010	0.028	0.014	9.6e-05	1.2e-04	1.0e-02	4.3e-05	2.9e-03
3	NTR	Blood	0.0213	0.0081	9.8e-05	0.024	0.011	0.015	0.014	0.019	3.1e-08	1.2e-04	9.4e-06	2.0e-05	6.9e-07
4	ROSMAP	Brain Pre-frontal Cortex	0.1023	0.0308	6.4e-09	0.066	0.069	0.052	0.072	0.067	7.6e-09	3.2e-09	2.6e-07	1.3e-09	5.9e-09
5	YFS	Blood	0.0390	0.0122	6.3e-07	0.018	0.027	0.026	0.030	0.025	1.4e-06	2.1e-09	3.6e-09	4.5e-10	9.9e-09
6	TCGA	Breast Invasive Carcinoma	0.0225	0.0127	1.1e-04	0.014	0.020	0.014	NA	0.020	6.1e-04	4.4e-05	5.0e-04	NA	5.0e-05
7	TCGA	Colon Adenocarcinoma	0.1020	0.0600	4.6e-03	0.056	0.018	0.024	NA	0.036	3.6e-04	3.0e-02	1.4e-02	NA	3.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Hair/balding pattern: Pattern 2	9.7	12.3	20.6	3.6	4.2	-3.0	2.8	-1.1	4.5	4.1
Ever had prostate specific antigen (PSA) test	4.8	5.6	10.0	1.9	2.6	-1.7	2.4	-1.8	2.6	3.2
Bipolar Disorder (2011)	4.6	4.4	8.4	1.6	2.1	-2.2	1.4	-0.9	2.9	2.8
Migraine (self-reported)	3.9	4.8	8.1	2.9	2.7	-2.2	1.9	1.5	2.3	1.6
Knee pain experienced in last month	3.8	5.9	9.8	-2.6	-1.7	3.1	-1.8	-1.0	-3.0	-3.0
Commuting to job workplace: Cycle	3.8	4.6	8.7	-3.0	-2.3	1.6	-2.6	-2.6	-1.3	-0.6
Medication: Omeprazole (e.g. Zanprol)	3.8	4.7	13.1	-1.3	-1.3	3.6	-1.3	-1.3	-2.5	-2.5
Medication: Omeprazole	3.3	4.0	8.1	-1.2	-2.0	2.5	-1.7	0.2	-2.3	-2.8
Supplements: Glucosamine	3.1	4.1	7.3	2.0	1.6	-1.9	2.6	-0.1	2.1	2.7
Ovarian Cancer	3.0	4.0	7.5	1.8	1.6	-1.5	1.3	-1.9	2.7	2.7
Past tobacco smoking	3.0	5.5	11.9	2.8	3.1	-1.9	3.4	1.0	1.8	1.4
Exposure to tobacco smoke at home	3.0	3.4	5.6	-1.4	-1.9	-0.0	-2.4	1.9	-1.9	-2.4
Diabetes diagnosed by doctor	3.0	4.9	8.4	-2.0	-2.9	1.9	-2.5	-0.5	-2.4	-2.4
Headache pain in last month	2.9	4.9	12.9	2.2	3.6	-2.0	1.8	0.9	2.2	2.0
Prospective memory result	2.7	3.4	6.5	-1.3	-1.7	0.8	-1.7	2.1	-2.2	-2.5
Medication: Metformin	2.6	3.7	9.4	-1.6	-1.4	1.2	-1.3	1.7	-2.5	-3.1
Lung cancer (father)	2.6	3.0	9.0	1.5	0.9	-3.0	1.3	0.6	2.1	1.5
Guilty feelings	2.6	3.9	7.2	2.0	1.5	-2.1	1.5	0.7	2.7	2.7
Ever smoked	2.5	4.3	11.0	-2.3	-3.0	1.3	-3.3	-0.3	-1.5	-1.0
Alzheimer’s Disease (in mother)	2.4	2.8	7.3	-2.0	-0.5	1.4	-0.4	-0.1	-2.4	-2.7
Sensitivity / hurt feelings	2.4	4.2	7.4	2.4	1.7	-2.7	1.5	0.4	2.7	1.9
Number of operations (self-reported)	2.4	3.5	6.8	-2.5	-1.4	1.8	-2.6	-0.8	-1.8	-1.6
Impedance of leg (right)	2.3	11.0	19.2	3.5	4.4	-2.0	2.4	-1.6	4.1	4.1
Mouth/teeth dental problems: Loose teeth	2.3	2.7	5.6	-2.4	-1.7	0.7	-1.1	1.2	-2.0	-1.9
Chest pain or discomfort	2.3	3.3	10.2	0.9	2.1	0.2	0.8	-3.2	1.8	2.0
Qualifications: nursing, teaching	2.3	3.6	8.3	2.5	2.1	-0.8	2.9	-0.2	1.8	1.4
Schizophrenia (2014)	2.2	4.9	7.8	2.7	0.8	-2.7	2.1	1.5	2.8	2.3
Impedance of leg (left)	2.2	10.5	19.7	3.2	4.4	-1.5	2.5	-2.1	3.8	3.9
Medication: Bendroflumethiazide	2.2	3.3	6.1	-1.9	-0.9	2.5	-0.9	-2.2	-2.0	-1.7
Type 2 Diabetes (T2D) (2018)	2.1	3.9	7.2	-1.7	-2.3	1.4	-2.1	-0.2	-2.3	-2.7
Impedance of whole body	2.1	10.6	20.1	3.7	4.5	-1.8	3.1	-1.0	3.8	3.5
Schizophrenia (2018)	2.0	4.2	9.3	2.3	1.1	-2.2	3.1	1.7	1.9	1.5
Hypothyroidism (self reported)	2.0	4.6	8.3	1.8	1.9	-1.7	2.9	-1.5	2.2	2.7
Bipolar Disorder or Schizophrenia	1.9	4.7	8.0	2.3	1.0	-2.8	2.5	0.9	2.6	2.2
Diabetes (mother)	1.9	2.5	4.5	-1.7	-0.6	1.8	-1.4	-0.2	-2.1	-2.1
Severe depression (siblings)	1.9	2.1	4.9	1.1	1.2	-1.1	1.2	-0.5	2.2	2.0
Diabetes (self-reported)	1.9	2.9	5.2	-1.6	-2.3	1.6	-1.5	-0.6	-2.0	-1.9
Pulse wave reflection index	1.9	2.3	3.9	1.5	2.0	-1.5	0.3	0.2	2.0	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	4.5	-0.9	-0.7	2.1	-1.5	-1.0	-1.4	-2.1
Breast Cancer	1.8	4.4	12.6	-1.8	-0.5	3.6	-1.6	-2.7	-1.9	-1.1
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.9	5.8	0.9	1.4	-2.0	1.1	-0.9	2.3	2.4
Handedness (chirality/laterality): Left-handed	1.8	2.1	5.4	1.9	2.3	-1.0	1.6	1.3	0.5	0.3
Mineral and other dietary supplements	1.8	2.4	4.8	-1.4	-1.8	0.9	-2.2	0.9	-1.4	-1.8
Neuroticism score	1.6	3.4	7.3	2.2	1.8	-1.7	1.0	0.2	2.7	2.1
Commuting to job workplace: Walk	1.6	1.7	3.3	-1.6	-0.1	1.5	-1.4	-1.8	-1.2	-0.5
Body Mass Index (BMI) (2010)	1.5	2.0	3.9	-0.9	-1.8	-0.3	-1.7	2.0	-1.1	-1.5
Blood Platelet Count	1.5	16.9	46.2	3.7	0.5	-6.8	1.9	2.4	5.4	4.3
BMI	1.5	8.8	21.3	-1.8	-3.6	-0.4	-1.4	4.6	-2.9	-3.7
Mood swings	1.5	2.7	6.1	0.7	1.3	-2.5	-1.0	1.2	2.1	2.0
Hearing aid user	1.5	1.7	4.4	-0.9	-1.5	0.5	-2.1	-1.8	0.0	0.9
Alzheimer’s Disease (including proxy)	1.4	2.0	6.7	-1.2	-0.9	0.8	0.1	0.7	-2.1	-2.6
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	3.3	-0.8	0.1	1.8	-0.9	-1.3	-1.5	-1.3
Medication: Levothyroxine sodium	1.4	2.3	4.1	1.1	1.2	-1.3	1.5	-1.4	1.9	2.0
Alcohol usually taken with meals	1.4	2.3	7.8	1.1	1.5	-1.7	2.8	1.2	0.4	0.6
Nervous feelings	1.4	2.6	8.6	1.7	2.9	-0.3	1.3	-0.4	1.5	1.5
Falls in the last year	1.4	1.8	4.2	-2.0	-1.7	-0.4	-2.0	0.8	-0.8	-0.8
Hair/balding pattern: Pattern 3	1.4	2.1	7.8	-1.3	-2.8	-0.5	-1.4	1.2	-0.9	-0.8
Family relationship satisfaction	1.4	1.7	3.4	-1.4	-0.7	1.7	-0.3	0.1	-1.7	-1.9
Breast cancer (self-reported)	1.4	1.7	3.0	1.2	1.6	-1.7	0.7	1.1	1.4	0.9
Supplements: Fish oil (including cod liver oil)	1.4	1.8	4.2	1.3	1.9	-0.7	2.1	-0.5	1.2	1.1
Medication: Atorvastatin	1.4	1.7	3.2	-1.6	-1.8	0.8	-0.4	0.2	-1.8	-1.5
Depressed Affect (Nagel 2018)	1.3	2.7	5.8	1.8	2.4	-1.5	0.3	0.5	2.1	1.7
Age at First Birth	1.3	1.9	3.9	1.1	1.9	-0.6	2.0	0.3	1.0	1.8
Blood White Count	1.3	9.4	17.2	-2.6	-1.4	4.2	-2.9	-0.4	-3.8	-4.0
Medication: Co-codamol	1.3	1.6	3.4	-1.5	-1.2	0.3	-1.8	0.9	-1.0	-1.4
Depression (self-reported)	1.3	1.6	3.1	1.1	1.5	-0.7	0.8	-0.8	1.8	1.7
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	4.2	1.3	1.7	-1.0	2.1	-1.6	1.6	1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.9	-1.6	-1.7	1.1	-1.5	-0.6	-0.9	-0.4
Age at first live birth	1.3	2.3	3.7	1.3	0.7	-1.1	1.6	-1.8	1.9	1.9
Health satisfaction	1.3	1.6	3.5	1.4	0.5	-1.5	1.3	1.9	1.2	0.3
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.6	1.9	0.3	-1.5	0.6	1.1	1.5	1.0
Smoking status: Current	1.3	2.0	7.1	-1.0	-1.6	0.9	-2.7	-1.5	-0.2	-0.6
Neuroticism (Nagel 2018)	1.2	2.8	5.1	1.6	2.0	-1.5	0.3	-0.0	2.3	2.3
Ulcerative Colitis	1.2	1.7	3.9	-0.6	0.8	2.0	1.2	-1.6	-1.4	-1.0
Neuroticism	1.2	2.8	5.2	2.1	2.1	-1.6	0.7	0.9	2.3	1.4
Stomach or abdominal pain in last month	1.2	1.6	4.6	1.5	2.2	-0.4	1.5	0.1	1.1	0.6
Medication: Ramipril	1.2	1.5	4.6	-0.6	1.0	2.1	-1.2	-1.2	-0.9	-0.9
Impedance of arm (right)	1.2	5.4	11.4	2.6	3.4	-1.4	1.8	-0.4	2.9	2.5
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	3.2	1.8	1.6	-1.4	1.0	0.7	1.6	1.1
Impedance of arm (left)	1.2	5.6	10.6	2.9	3.3	-1.4	2.3	-0.5	2.8	2.3
Exposure to tobacco smoke outside home	1.2	1.6	3.0	1.2	1.2	-1.7	0.2	1.3	1.6	1.1
Shortness of breath walking on level ground	1.2	1.5	6.0	1.3	0.5	-1.0	0.5	2.4	0.5	-1.0
Medication: Seretide 50 evohaler	1.2	1.4	3.7	-1.2	0.3	1.1	-0.3	0.4	-1.7	-1.9
Supplements: Vitamin C	1.2	1.4	2.9	-1.5	-1.7	0.9	-0.6	-0.9	-1.4	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	4.1	-1.0	-0.8	0.8	-2.0	0.8	-1.1	-0.7
Osteoarthritis (self-reported)	1.2	1.5	2.9	-1.5	-1.7	0.8	-1.2	-0.1	-1.4	-1.1
Leg predicted mass (right)	1.2	6.2	11.7	-2.5	-3.1	0.4	-1.3	2.5	-2.8	-3.4
Rheumatoid Arthritis	1.1	1.5	3.5	1.9	1.1	-0.5	1.9	-0.2	1.3	0.6
Frequency of depressed mood in last 2 weeks	1.1	1.6	3.8	0.8	1.3	-1.4	0.7	-0.2	1.6	2.0
Leg fat-free mass (left)	1.1	5.6	10.8	-2.1	-2.8	-0.0	-1.2	2.9	-2.5	-3.3
Leg predicted mass (left)	1.1	5.6	10.7	-2.1	-2.8	-0.0	-1.2	3.0	-2.4	-3.3
Number of live births	1.1	1.5	3.5	-1.9	-1.7	0.3	-1.7	0.2	-1.0	-0.3
Leg fat-free mass (right)	1.1	6.1	11.8	-2.5	-3.0	0.4	-1.3	2.5	-2.8	-3.4
Medication: Gliclazide	1.1	1.2	1.9	-1.1	-1.0	0.9	-1.3	0.8	-1.4	-1.1
Wears glasses or contact lenses	1.1	1.2	5.8	1.3	2.4	-0.2	0.5	0.6	0.7	0.4
Tinnitus: Yes, now most or all of the time	1.1	1.3	4.4	1.0	0.2	-1.1	0.9	-0.7	1.1	2.1
Schizophrenia vs Biploar Disorder	1.0	1.4	3.3	1.7	0.4	-0.8	0.4	-0.6	1.8	1.5
Current tobacco smoking	1.0	1.6	6.7	-0.6	-1.0	0.7	-2.6	-1.5	0.2	-0.3
Fed-up feelings	1.0	1.9	4.0	1.6	1.5	-1.2	-0.0	-0.7	2.0	1.6
Relative age voice broke	1.0	1.5	3.4	-1.5	-1.8	0.8	-0.7	-0.2	-1.1	-1.6
Worry too long after embarrassment	1.0	1.7	3.4	1.1	1.1	-1.3	1.0	-0.5	1.8	1.8
Osteoporosis (self-reported)	1.0	1.2	1.9	1.3	1.2	-1.3	0.3	0.6	1.4	1.1
Number of self-reported non-cancer illnesses	1.0	1.8	4.2	-1.6	-0.0	1.2	-2.1	-0.8	-1.0	-1.6
Miserableness	1.0	1.7	3.7	1.5	1.3	-1.4	0.2	1.0	1.9	1.3
Bipolar Disorder (2018)	0.9	1.5	3.3	0.8	0.3	-1.8	0.3	-0.7	1.8	1.6
Depression (Nagel 2018)	0.9	1.3	3.6	0.6	1.3	-1.2	-0.2	-0.4	1.4	1.9
Ulcerative Colitis (UC)	0.9	1.8	4.0	0.0	1.1	1.6	2.0	-1.6	-1.1	-0.9
Neuroticism (2016)	0.9	1.2	2.4	1.5	1.4	-0.9	0.9	0.5	1.3	1.1
Smoking Status	0.9	2.2	7.1	-1.7	-2.0	0.7	-2.7	-0.3	-0.7	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.0	1.3	1.2	-0.6	1.1	-0.2	1.4	1.4
Time employed in main current job	0.9	1.0	1.9	-1.2	0.5	0.9	-0.8	0.1	-1.4	-1.4
Chronic bronchitis/emphysema (mother)	0.9	1.1	3.2	1.5	0.9	-0.3	0.6	1.8	0.7	0.6
Medication: Allopurinol	0.9	1.2	2.0	-1.4	-1.4	0.4	-1.3	0.4	-1.0	-1.3
Age at last live birth	0.9	1.3	3.0	0.9	1.0	-0.8	0.6	-1.2	1.2	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.7	1.0	1.0	-1.2	1.0	0.5	1.3	1.0
Back pain experienced in last month	0.9	1.2	3.6	1.0	0.9	0.8	1.3	-1.9	0.8	0.5
Unable to work because of sickness or disability	0.9	1.2	4.4	-1.1	-1.2	0.6	-2.1	-0.3	-0.3	-0.6
Heart disease (siblings)	0.9	1.1	3.2	-0.3	-1.8	-1.7	-0.7	0.6	0.7	0.4
Coronary Artery Disease (CAD)	0.8	1.0	2.2	-0.9	-0.5	0.2	-1.5	1.2	-0.8	-1.1
LDL Cholesterol	0.8	1.2	4.8	0.5	-0.8	-2.2	-0.9	1.2	0.8	0.4
Lupus	0.8	1.2	3.0	-1.0	-0.9	1.2	-0.7	0.4	-1.7	-1.3
Heel T-Score	0.8	6.0	27.4	-2.0	-5.2	1.3	-2.6	0.1	-1.3	-0.7
Hand grip strength (left)	0.8	2.1	6.8	1.6	1.2	-0.4	2.6	1.6	-0.2	-0.9
Angina	0.8	1.1	4.2	-0.6	0.1	0.7	-2.0	-1.4	-0.2	-0.6
Diabetes (father)	0.8	1.0	2.7	-0.3	-0.1	0.8	1.2	1.0	-1.1	-1.6
Average weekly fortified wine intake	0.8	1.0	2.7	0.9	1.7	0.1	1.6	-0.4	0.4	0.6
Multivitamins +/- minerals	0.8	1.0	3.7	-0.7	0.0	-0.1	-1.1	-1.9	0.3	1.2
Body mass index (BMI)	0.8	3.6	7.8	-1.1	-2.8	-0.2	-1.3	2.6	-1.6	-2.3
Waist circumference	0.8	2.9	10.6	-0.5	-1.8	-1.5	-0.9	3.3	-0.7	-1.6
Had menopause	0.8	1.0	3.3	1.0	1.3	0.4	1.8	-0.2	0.8	0.4
Heart attack	0.8	1.0	2.5	-0.4	-0.7	1.1	-0.4	0.6	-1.5	-1.6
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.2	0.0	0.9	0.5	-1.2	-1.5	0.8	1.4
Birth weight	0.8	1.8	3.3	1.1	1.1	-1.4	1.8	-0.2	1.3	1.8
Angina (self-reported)	0.8	1.1	4.2	-0.5	0.0	0.7	-2.1	-1.4	-0.2	-0.6
Medication: Ibuprofen	0.8	1.0	2.4	0.8	1.5	-0.9	1.3	0.5	0.8	0.8
Whole body fat-free mass	0.8	4.6	8.5	-2.4	-2.4	0.1	-1.3	2.1	-2.5	-2.9
Illnesses of father: None of the above (group 1)	0.8	1.0	2.2	-1.2	0.2	1.0	-1.5	-1.2	-0.7	-0.8
Whole body water mass	0.8	4.6	8.1	-2.4	-2.5	0.0	-1.2	2.1	-2.5	-2.9
Basal metabolic rate	0.8	4.2	7.7	-2.1	-2.4	-0.3	-1.1	2.5	-2.2	-2.8
Fractured/broken bones in last 5 years	0.8	1.0	2.8	-0.6	0.3	-1.0	-0.5	-1.0	1.2	1.7
Diastolic blood pressure, automated reading	0.8	2.5	3.5	1.9	1.7	-1.7	1.7	1.1	1.4	1.3
Basal cell carcinoma (self-reported)	0.8	0.9	1.8	1.1	0.6	-1.3	0.7	0.1	1.1	1.2
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.5	-0.3	-0.8	1.1	-0.3	0.6	-1.5	-1.6
Alzheimer’s Disease (in father)	0.7	0.8	1.8	-0.3	-1.1	0.7	-0.1	0.5	-1.3	-1.3
HDL Cholesterol	0.7	1.1	2.2	1.1	1.5	-0.7	1.1	0.5	1.0	1.1
Blood Eosinophil Count	0.7	5.5	12.6	-1.5	-0.4	3.5	-1.7	-0.7	-2.9	-3.4
Blood Red Count	0.7	7.1	18.7	1.2	3.0	4.3	2.9	-2.8	-1.4	-1.4
Average weekly spirits intake	0.7	0.8	3.3	-0.1	-0.7	0.5	-1.3	-1.8	0.0	0.5
Hearing difficulty/problems: Yes	0.7	1.1	5.3	-0.3	-0.4	0.3	-2.3	-0.7	0.4	1.2
Medication for hormone replacement therapy	0.7	0.8	2.2	0.6	-1.5	-0.9	-0.9	0.3	1.0	0.4
Weight	0.7	3.6	9.3	-1.2	-2.1	-0.8	-0.8	3.1	-1.6	-2.5
Father’s age at death	0.7	0.9	2.9	0.2	-0.0	0.1	1.7	1.0	-0.9	-1.3
Pulse rate	0.7	1.2	4.8	0.7	0.5	-1.6	-0.1	2.2	0.4	-0.3
Noisy workplace	0.7	0.8	1.9	-0.5	-1.0	-1.4	-0.8	1.3	0.3	-0.2
Medication: Cholesterol lowering	0.7	1.0	2.9	-1.1	-0.3	1.1	-0.8	0.0	-1.0	-1.7
Arm fat mass (right)	0.7	2.9	6.5	-0.9	-2.3	-0.8	-1.1	2.5	-1.1	-2.1
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.9	1.0	0.6	-1.2	-0.1	0.4	1.4	1.1
Glaucoma (self-reported)	0.7	0.8	2.0	0.4	1.4	-1.1	-0.0	0.9	0.8	0.9
Arm fat-free mass (right)	0.7	3.6	6.1	-2.0	-2.3	-0.0	-1.0	1.9	-2.2	-2.5
Pulse wave peak to peak time	0.7	0.8	1.8	0.6	-0.8	-0.4	0.5	-1.3	1.0	1.2
Medication for pain relief, constipation, heartburn	0.7	1.2	4.3	-1.6	-2.1	0.0	-1.0	-0.9	-0.0	0.2
Neck or shoulder pain in last month	0.7	1.0	2.9	0.2	1.5	0.8	-0.4	-1.7	0.6	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.8	0.2	1.3	0.7	0.7	-1.0	0.7	1.0
Suffer from ‘nerves’	0.7	1.1	2.5	0.9	1.6	-1.2	0.2	-0.7	1.4	1.0
Illnesses of father: Heart disease	0.7	1.0	2.3	0.7	0.7	-1.0	1.5	0.6	0.8	1.3
Loneliness, isolation	0.7	1.0	1.8	1.2	1.3	-0.2	1.0	-0.3	1.1	1.1
Friendships satisfaction	0.7	0.9	3.0	-0.2	0.2	1.7	0.8	-0.3	-0.9	-1.1
Arm fat mass (left)	0.7	2.8	6.7	-0.8	-2.3	-0.8	-0.9	2.6	-1.1	-2.1
Medication: Lisinopril	0.7	0.9	2.7	-1.1	-1.1	0.1	-1.7	0.1	-0.8	-0.6
Alcohol drinker status: Never	0.7	0.8	1.5	-1.0	-0.2	1.1	-0.8	0.5	-1.2	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.5	-0.3	-1.1	-1.4	0.4	1.6	0.1	-0.2
Major Depression (MDD)	0.6	0.7	2.6	0.7	0.1	-1.1	-0.4	1.6	0.5	-0.3
Number of treatments/medications taken	0.6	1.1	2.3	-1.0	0.2	1.3	-0.6	-0.7	-1.5	-1.4
Medication: Atenolol	0.6	0.8	2.9	1.1	1.7	-0.2	0.5	0.8	0.4	-0.5
Hearing difficulty/problems with background noise	0.6	1.0	3.3	0.5	0.8	-0.6	-1.8	0.2	1.1	0.9
Had other major operations	0.6	0.7	2.3	-1.2	0.0	0.2	-1.5	-0.7	-0.5	-0.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.0	0.5	1.1	-0.1	1.4	1.1	0.1	-0.3
Trunk fat-free mass	0.6	3.4	5.9	-2.4	-2.0	-0.1	-1.4	1.4	-2.2	-2.3
Alcohol intake versus 10 years previously	0.6	0.8	3.2	0.4	0.3	1.0	-0.3	-1.8	0.6	0.9
Trunk predicted mass	0.6	3.4	6.0	-2.5	-2.0	-0.2	-1.4	1.5	-2.2	-2.3
Blood clot in the leg (DVT)	0.6	0.7	2.0	-0.3	-0.9	-1.4	0.6	1.3	0.2	-0.1
Medication: Paracetamol	0.6	1.1	3.7	1.2	1.9	-0.3	1.0	0.9	0.6	0.4
Comparative body size at age 10	0.6	1.7	5.1	0.3	-0.7	-2.2	0.5	0.7	1.6	1.7
Whole body fat mass	0.6	2.4	6.8	-0.5	-1.8	-1.0	-0.7	2.6	-0.7	-2.0
Leg fat mass (right)	0.6	2.1	6.1	-0.6	-1.9	-0.9	-0.7	2.5	-0.7	-1.8
Arm predicted mass (right)	0.6	3.3	6.2	-1.9	-2.2	0.1	-0.8	1.8	-2.2	-2.5
Had major operations	0.6	0.7	3.1	-0.8	-0.4	0.5	-0.9	-1.8	0.2	0.2
Smoking status: Previous	0.6	1.0	1.7	-1.3	-1.3	0.9	-1.2	-0.4	-0.8	-0.6
Ever had bowel cancer screening	0.6	0.7	1.3	1.0	0.8	-1.1	0.2	0.1	1.1	1.0
Eye problems/disorders: Cataract	0.6	0.7	1.3	-0.9	0.2	0.1	-0.2	1.1	-1.1	-1.1
Commuting to job workplace: Public transport	0.6	0.7	1.3	0.8	0.6	-1.1	1.1	0.8	0.8	0.3
Arm fat-free mass (left)	0.6	2.9	5.3	-1.7	-1.8	-0.5	-0.6	2.3	-1.8	-2.2
Risk taking	0.6	0.8	5.4	-0.3	0.1	-0.2	-0.2	2.3	-0.4	0.0
Arm predicted mass (left)	0.6	2.8	5.3	-1.6	-1.9	-0.6	-0.6	2.3	-1.7	-2.1
Worry (Nagel 2018)	0.5	1.2	2.4	0.8	1.3	-0.8	-0.2	-0.7	1.5	1.6
Crohns Disease (2012)	0.5	0.8	1.8	0.3	-0.3	-0.5	0.8	-1.2	1.3	1.3
Mean Putamen Volume	0.5	0.6	1.8	-1.0	-1.3	0.6	-0.7	-0.6	0.0	0.3
Cardiovascular Disease	0.5	1.5	3.8	-2.0	-1.0	-0.0	-1.3	0.6	-1.4	-1.4
Systolic blood pressure, automated reading	0.5	1.5	3.0	1.3	1.0	-1.0	1.7	-0.8	1.2	1.3
Pack years adult smoking proportion	0.5	0.7	3.0	-0.4	-1.0	-0.2	-1.7	0.7	-0.2	-0.4
Maternal smoking around birth	0.5	0.7	2.5	-0.4	-0.6	1.6	-0.5	-1.0	-0.5	0.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	0.6	0.4	-0.6	-0.1	0.2	1.3	1.3
High blood pressure (mother)	0.5	0.7	1.2	1.0	1.0	0.2	1.1	-0.8	0.5	0.9
Trunk fat mass	0.5	1.9	7.2	-0.0	-1.3	-1.1	-0.2	2.7	-0.5	-1.8
Illnesses of siblings	0.5	0.8	2.2	0.3	1.3	0.5	0.6	-1.5	-0.3	0.7
Arm fat percentage (right)	0.5	1.8	5.3	-0.3	-1.9	-0.9	-1.0	2.3	-0.4	-1.5
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	4.8	1.0	1.1	-0.9	2.2	1.8	0.0	0.0
Asthma	0.5	1.0	2.4	-0.6	0.6	1.6	-1.5	-0.7	-0.4	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.0	0.7	1.4	-0.4	1.0	0.6	0.2	0.1
Illnesses of mother	0.5	0.7	1.8	0.6	-0.4	-1.1	-0.8	0.0	1.3	0.8
Pulse wave Arterial Stiffness index	0.5	0.6	1.8	-0.4	1.0	0.1	-0.3	1.3	-0.7	-1.0
Length of working week for main job	0.5	0.5	1.3	-0.3	-1.0	-1.2	-0.8	0.6	0.4	0.2
Breastfed as a baby	0.5	0.6	2.1	-0.4	0.5	-1.1	1.4	0.5	0.1	0.5
Birth weight of first child	0.5	0.9	1.9	-1.4	-1.2	-0.6	-0.5	1.0	-0.7	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.5	0.7	1.2	-0.7	0.6	0.8	0.8	0.5
Number of full sisters	0.5	0.6	1.3	1.1	0.5	0.1	0.4	-0.7	1.0	0.8
Overall health rating	0.5	1.0	2.6	1.2	0.8	-1.0	0.2	1.6	1.2	0.1
Leg pain on walking	0.5	0.6	2.5	0.4	0.5	-0.4	0.9	1.6	0.0	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	3.6	-0.3	-0.6	-1.4	-0.8	1.9	-0.1	-0.2
Arm fat percentage (left)	0.5	2.0	5.6	-0.2	-2.0	-0.9	-0.8	2.4	-0.5	-1.6
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.9	-1.2	-1.4	0.7	-0.4	-0.7	-0.4	0.6
Asthma (self-reported)	0.5	1.1	2.4	-0.7	0.9	1.6	-1.4	-0.9	-0.3	-0.9
Average weekly champagne plus white wine intake	0.5	0.7	3.0	-1.7	-1.1	-0.2	-0.4	0.4	-0.6	-0.1
Financial situation satisfaction	0.5	0.6	2.2	0.4	1.0	-0.4	0.3	1.5	0.4	-0.4
Medication: Paracetamol	0.5	0.8	2.3	1.1	1.5	-0.6	0.7	0.7	0.7	0.7
Age started oral contraceptive pill	0.5	0.7	2.3	-0.8	-0.6	0.8	0.1	-1.5	-0.8	-0.0
Leg fat mass (left)	0.5	2.1	5.9	-0.6	-1.9	-0.9	-0.6	2.4	-0.7	-1.8
Reaction Time	0.4	0.7	2.1	0.3	1.5	-1.3	0.7	0.8	0.2	0.2
Primary Biliary Cirrhosis	0.4	0.5	1.1	0.4	-0.0	-1.0	0.8	0.2	0.8	1.0
Chronotype (morning person)	0.4	0.8	1.8	-1.0	-0.8	1.0	-0.3	0.3	-1.3	-1.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.8	-0.5	0.1	-0.1	0.4	1.1	-0.4	-1.4
Vitamin and mineral supplements	0.4	0.6	2.0	0.5	-0.2	0.1	0.8	1.4	-0.1	-1.1
Trunk fat percentage	0.4	1.5	5.9	1.1	-0.5	-1.3	0.5	2.4	0.5	-0.9
Hand grip strength (right)	0.4	1.2	4.8	1.3	0.6	-0.5	2.2	0.9	-0.1	-0.5
Townsend deprivation index at recruitment	0.4	0.6	1.7	-0.5	-0.7	-0.3	-0.6	-0.3	1.0	1.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.6	-0.4	-0.7	-0.2	-1.1	-1.3	0.3	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	4.2	-0.2	-2.1	0.2	-1.2	0.5	-0.6	-0.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	-1.0	-0.2	0.6	-0.4	0.4	-0.8	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	3.9	0.0	-2.0	0.2	-0.9	1.1	-0.7	-0.7
Qualifications: None of the above	0.4	0.8	2.2	-0.9	-1.1	0.6	-1.5	-0.8	-0.5	-0.3
Mouth/teeth dental problems	0.4	0.5	2.7	0.1	-0.7	0.1	-0.4	-1.6	-0.1	-0.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.4	-0.4	0.8	0.5	1.2	-0.9	-0.4	-0.1
Fluid intelligence score	0.4	0.7	3.1	-0.8	-0.3	0.1	-1.1	-1.8	0.0	0.4
Hip circumference	0.4	1.9	7.6	0.1	-0.6	-0.5	0.9	2.8	-1.0	-1.9
Worrier / anxious feelings	0.4	0.7	1.4	-0.7	-1.1	0.7	-1.1	-1.2	0.0	0.5
Happiness	0.4	0.4	0.8	-0.7	-0.3	0.9	-0.3	0.4	-0.8	-0.9
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.4	0.6	0.7	-0.7	0.7	-1.1	1.0	1.2
Mouth/teeth dental problems: Dentures	0.4	0.6	3.5	-0.1	0.5	-0.6	0.4	1.9	-0.0	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.4	0.8	1.0	-0.5	-0.7	-0.1	1.2	1.0
Hair/balding pattern: Pattern 4	0.4	0.9	2.7	-0.6	-0.1	1.6	-0.1	0.2	-1.6	-0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.1	-0.3	1.4	0.5	0.9	0.3	-0.3	-0.1
Body fat percentage	0.4	1.4	5.8	0.8	-0.7	-1.4	0.2	2.4	0.4	-0.9
Wheeze or whistling in the chest in last year	0.4	0.7	2.1	-1.0	-0.1	0.7	-1.5	-0.8	-0.0	-0.6
Number of children fathered	0.4	0.5	1.2	0.9	0.3	-0.2	0.2	-0.8	0.8	1.1
Emphysema/chronic bronchitis	0.4	0.5	1.0	0.5	1.0	-0.4	0.6	0.2	0.8	0.8
Mean time to correctly identify matches	0.4	0.8	3.3	0.5	1.8	-1.0	0.8	0.4	0.3	0.2
Heart disease (mother)	0.4	0.5	1.5	-1.0	-1.2	-0.2	-0.6	0.0	-0.6	-0.0
Comparative height size at age 10	0.4	2.3	4.4	1.3	2.1	-2.0	1.6	1.1	1.4	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	-0.8	-0.5	1.0	-0.8	-0.6	-0.8	-0.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	-1.0	-1.1	0.6	-0.4	-0.7	-0.6	-0.4
Average weekly red wine intake	0.4	0.5	1.4	0.5	-0.0	-0.5	-0.3	-1.1	0.6	1.2
Eye problems/disorders: Glaucoma	0.4	0.4	1.1	0.3	1.0	-0.0	-0.9	-0.5	0.5	0.8
Supplements: Calcium	0.4	0.4	1.1	0.0	0.8	0.4	0.9	-0.1	-0.1	-1.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.0	-1.7	-0.6	0.7	-1.1	-0.8	-1.1	-0.2
Irritable Bowel Disease (IBD)	0.3	0.7	2.2	-0.2	0.3	0.8	1.5	-1.4	-0.4	-0.1
Fasting Glucose	0.3	0.4	0.9	0.6	1.0	-0.2	-0.9	-0.3	0.6	0.3
HbA1C	0.3	0.3	1.5	0.0	0.1	0.3	0.1	-1.2	0.5	0.4
Triglycerides	0.3	0.6	1.5	0.7	-0.0	-0.7	-1.2	1.2	0.3	-0.0
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.2	0.4	0.0	-0.3	-0.5	1.1	0.1	0.5
Waist Hip Ratio (WHR)	0.3	1.5	4.1	-0.4	-0.5	-2.0	-1.8	1.3	0.6	0.6
Allergy or Eczema	0.3	0.8	2.7	0.2	1.6	0.4	0.2	-1.6	0.4	0.3
Respiratory disease	0.3	0.7	1.7	-0.1	1.1	1.3	-0.5	0.6	-0.5	-1.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	-0.0	-0.4	-0.0	-1.0	-0.7	0.6	0.8
Supplements: Zinc	0.3	0.3	0.9	0.5	-0.4	-0.9	0.5	0.5	0.6	-0.0
Taking other prescription medications	0.3	0.5	1.2	0.2	0.8	0.6	-0.9	-0.1	-0.4	-1.1
Age when periods started (menarche)	0.3	0.7	1.6	-1.3	-1.1	0.2	0.0	0.1	-0.8	-1.2
Qualifications: CSEs or equivalent	0.3	0.4	1.0	1.0	1.0	0.3	0.3	0.4	0.4	0.1
Serious illness, injury or assault to yourself	0.3	0.4	0.8	-0.8	0.1	-0.0	-0.0	0.6	-0.9	-0.8
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.4	-0.2	1.3	0.5	0.2	-1.6	-0.0	0.0
Number of incorrect matches in round	0.3	0.4	0.9	0.8	0.9	0.1	0.1	-0.5	0.6	1.0
Pain all over the body in last month	0.3	0.3	1.0	-0.3	-1.0	-0.5	-0.9	-0.1	0.3	0.4
Medication: Lansoprazole	0.3	0.3	0.5	-0.7	-0.5	0.4	-0.7	-0.6	-0.7	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	3.2	0.3	0.4	-0.9	1.4	1.8	-0.2	0.2
Tense / ‘highly strung’	0.3	0.6	1.2	0.5	0.7	-1.1	-0.3	0.0	1.0	1.0
Gout (self-reported)	0.3	0.4	1.1	-0.1	-0.8	-1.0	-0.5	1.1	0.0	-0.3
High blood pressure (siblings)	0.3	0.4	0.9	-0.0	-0.6	-0.9	-0.2	1.0	0.8	-0.1
Leg fat percentage (right)	0.3	1.3	3.8	0.8	-0.7	-1.7	0.2	1.9	0.9	-0.0
Number of full brothers	0.3	0.4	1.3	-0.5	-0.4	0.2	-1.1	-0.9	0.2	0.2
Qualifications: College or University degree	0.3	0.8	2.1	-1.3	-0.7	0.4	-1.4	-0.5	-0.8	-0.3
Eye problems/disorders: None of the above	0.3	0.3	1.6	-0.2	-1.3	0.1	0.1	-0.4	0.4	0.5
Illnesses of siblings: Diabetes	0.3	0.3	0.9	-0.7	-0.7	-0.5	0.1	0.9	-0.2	-0.2
Long-standing illness, disability or infirmity	0.3	0.5	1.6	0.4	0.8	-0.8	-0.5	1.3	0.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.8	0.8	1.0	-0.2	1.1	1.3	-0.2	-0.3
Ever taken oral contraceptive pill	0.3	0.4	0.8	-0.7	-0.9	0.4	0.1	0.2	-0.8	-0.6
Mother’s age at death	0.3	0.4	1.3	-0.1	0.5	1.1	0.4	-1.0	-0.6	0.3
High cholesterol (Self-reported)	0.3	0.5	1.4	-0.0	0.8	1.0	0.3	-1.2	-0.1	-0.4
Illnesses of father: High blood pressure	0.3	0.4	1.5	0.4	0.4	-0.1	1.2	-0.4	0.6	0.7
Average weekly beer plus cider intake	0.3	0.4	1.3	-0.8	0.1	1.1	-0.2	-1.0	-0.4	0.1
Ever depressed for a whole week	0.3	0.4	0.9	-0.0	-0.1	1.0	0.9	-0.7	-0.4	-0.2
Myopia	0.3	0.4	0.9	0.1	0.4	-0.9	0.4	-0.7	0.9	0.7
Pain experienced in last month	0.3	0.5	2.5	-0.1	-1.6	-0.5	-0.3	0.7	-0.2	0.2
Pack years of smoking	0.3	0.5	2.2	-0.1	-0.5	-0.0	-1.5	0.7	-0.1	-0.4
Crohns Disease (2017)	0.2	0.5	1.3	-0.2	-0.7	-0.2	0.4	-1.1	0.6	1.0
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.2	-0.5	-0.5	0.3	-0.8	-1.5	0.2	0.5
Systolic Blood Pressure	0.2	0.8	2.7	0.5	1.1	0.0	0.9	-1.6	0.8	0.5
Lung FVC	0.2	1.1	2.0	1.0	0.2	-0.9	1.3	1.4	0.7	1.4
Relative age of first facial hair	0.2	0.4	1.0	-0.3	-0.1	0.2	0.8	0.8	-0.5	-1.0
Sitting height	0.2	1.1	3.9	0.4	2.0	0.4	1.5	-1.1	-0.0	-0.5
Forced vital capacity (FVC)	0.2	0.8	2.6	0.2	0.3	-0.7	1.4	1.6	-0.4	-0.2
Financial difficulties in last 2 years	0.2	0.3	0.7	0.2	0.4	-0.4	-0.5	0.4	0.8	0.6
Medication: Simvastatin	0.2	0.3	1.2	0.0	1.1	0.2	-0.2	0.4	0.2	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.7	0.2	0.5	0.8	0.5	-0.4	-0.6	-0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	-0.8	-0.2	0.6	-0.1	-0.4	-0.7	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	1.0	-0.0	-0.4	0.6	0.0	0.4	0.7
Medication: Blood pressure	0.2	0.3	0.7	-0.8	0.1	0.6	-0.6	-0.5	-0.2	0.0
Medication for cholesterol	0.2	0.3	1.0	0.0	0.8	0.2	1.0	0.3	0.2	0.2
Medication: Blood pressure	0.2	0.3	0.8	-0.4	-0.0	0.4	-0.6	-0.0	-0.8	-0.9
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	0.3	0.2	0.4	0.5	-0.6	-0.0	-0.7
Leg fat percentage (left)	0.2	0.9	3.1	0.5	-0.8	-1.3	0.0	1.8	0.5	-0.4
Irritability	0.2	0.4	1.3	-0.4	-1.1	0.1	-1.1	0.2	-0.1	-0.2
Alcohol drinker status: Previous	0.2	0.3	0.4	0.5	0.7	-0.6	0.1	-0.6	0.6	0.5
Prostate Cancer	0.1	0.2	0.5	0.2	0.3	-0.5	-0.7	0.2	0.3	0.7
Height	0.1	1.8	8.6	0.1	2.9	-0.3	1.8	0.3	-0.2	-0.7
Lung FEV1/FVC ratio	0.1	0.7	3.0	0.7	1.7	-0.5	0.5	0.4	0.6	0.3
Tanning	0.1	0.6	2.3	-0.3	0.2	0.6	-0.6	-1.5	0.5	1.0
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.0	-0.5	0.3	-0.6	0.3	-0.1	-0.5
High blood pressure	0.1	0.4	1.5	-1.2	-0.4	-0.0	-0.8	-0.5	-0.4	-0.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.5	0.7	0.4	0.3	-0.2	-0.2	0.2	-0.1
Allergy	0.1	0.3	0.5	0.5	-0.6	-0.7	-0.3	0.6	0.1	0.4
Standing height	0.1	0.9	2.1	-0.5	1.4	-1.2	0.9	1.0	-0.3	-0.7
Peak expiratory flow (PEF)	0.1	0.3	1.8	-0.2	-0.1	-0.5	0.1	1.3	-0.1	-0.3
Medication: Amlodipine	0.1	0.1	0.3	-0.4	-0.1	-0.6	0.3	-0.2	0.3	0.0
Forced vital capacity (FVC), Best measure	0.1	0.5	2.1	-0.4	-0.2	-0.7	0.6	1.5	-0.5	0.2
Pulse rate, automated reading	0.1	0.5	1.2	-0.1	0.0	0.7	-0.8	-0.0	-1.0	-1.1
Alcohol intake frequency.	0.1	0.1	0.5	0.2	-0.3	-0.4	0.4	0.7	-0.0	-0.3
Medication: Aspirin	0.1	0.2	0.6	0.8	0.4	-0.1	-0.5	0.2	0.1	0.3
Hypertension (Self-reported)	0.1	0.3	1.1	-1.0	-0.2	-0.2	-0.8	-0.4	-0.1	0.1
Medication: Aspirin	0.1	0.1	0.6	0.7	0.4	-0.0	-0.3	0.4	-0.0	-0.2
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.2	1.1	0.1	-0.0	1.0	0.7	0.3	0.1
Cholesterol lowering medication	0.1	0.2	1.0	0.1	-0.4	-1.0	0.0	-0.0	0.2	-0.1
Hair Pigment	0.0	0.6	1.7	-0.9	-1.3	-0.8	-0.4	0.8	-0.4	-0.6
Loud music exposure frequency	0.0	0.0	0.1	0.2	-0.1	-0.1	0.0	0.3	0.3	-0.2

Hub : Genes

YME1L1

Models

Trait associations