Hub : Genes

YME1L1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells EBV-transformed lymphocytes 0.1220 0.0570 6.2e-03 0.005 NA -0.005 NA 0.011 2.2e-01 NA 5.0e-01 NA 1.4e-01
2 METSIM Adipose 0.0478 0.0180 2.5e-05 0.025 0.024 0.010 0.028 0.014 9.6e-05 1.2e-04 1.0e-02 4.3e-05 2.9e-03
3 NTR Blood 0.0213 0.0081 9.8e-05 0.024 0.011 0.015 0.014 0.019 3.1e-08 1.2e-04 9.4e-06 2.0e-05 6.9e-07
4 ROSMAP Brain Pre-frontal Cortex 0.1023 0.0308 6.4e-09 0.066 0.069 0.052 0.072 0.067 7.6e-09 3.2e-09 2.6e-07 1.3e-09 5.9e-09
5 YFS Blood 0.0390 0.0122 6.3e-07 0.018 0.027 0.026 0.030 0.025 1.4e-06 2.1e-09 3.6e-09 4.5e-10 9.9e-09
6 TCGA Breast Invasive Carcinoma 0.0225 0.0127 1.1e-04 0.014 0.020 0.014 NA 0.020 6.1e-04 4.4e-05 5.0e-04 NA 5.0e-05
7 TCGA Colon Adenocarcinoma 0.1020 0.0600 4.6e-03 0.056 0.018 0.024 NA 0.036 3.6e-04 3.0e-02 1.4e-02 NA 3.5e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.9 1.5 3.3 0.8 0.3 -1.8 0.3 -0.7 1.8 1.6
Bipolar Disorder or Schizophrenia 1.9 4.7 8.0 2.3 1.0 -2.8 2.5 0.9 2.6 2.2
Depressed Affect (Nagel 2018) 1.3 2.7 5.8 1.8 2.4 -1.5 0.3 0.5 2.1 1.7
Depression (Nagel 2018) 0.9 1.3 3.6 0.6 1.3 -1.2 -0.2 -0.4 1.4 1.9
Intelligence (Savage-Jansen 2018) 0.3 1.0 3.0 -1.7 -0.6 0.7 -1.1 -0.8 -1.1 -0.2
Neuroticism (Nagel 2018) 1.2 2.8 5.1 1.6 2.0 -1.5 0.3 -0.0 2.3 2.3
Schizophrenia (2018) 2.0 4.2 9.3 2.3 1.1 -2.2 3.1 1.7 1.9 1.5
Schizophrenia vs Biploar Disorder 1.0 1.4 3.3 1.7 0.4 -0.8 0.4 -0.6 1.8 1.5
Worry (Nagel 2018) 0.5 1.2 2.4 0.8 1.3 -0.8 -0.2 -0.7 1.5 1.6
Alzheimer’s Disease (in mother) 2.4 2.8 7.3 -2.0 -0.5 1.4 -0.4 -0.1 -2.4 -2.7
Alzheimer’s Disease (in father) 0.7 0.8 1.8 -0.3 -1.1 0.7 -0.1 0.5 -1.3 -1.3
Alzheimer’s Disease (including proxy) 1.4 2.0 6.7 -1.2 -0.9 0.8 0.1 0.7 -2.1 -2.6
Crohns Disease (2017) 0.2 0.5 1.3 -0.2 -0.7 -0.2 0.4 -1.1 0.6 1.0
Irritable Bowel Disease (IBD) 0.3 0.7 2.2 -0.2 0.3 0.8 1.5 -1.4 -0.4 -0.1
Ulcerative Colitis (UC) 0.9 1.8 4.0 0.0 1.1 1.6 2.0 -1.6 -1.1 -0.9
Major Depression (MDD) 0.6 0.7 2.6 0.7 0.1 -1.1 -0.4 1.6 0.5 -0.3
Reaction Time 0.4 0.7 2.1 0.3 1.5 -1.3 0.7 0.8 0.2 0.2
Verbal and Numeric Reasoning (VNR) 0.2 0.5 2.2 -0.5 -0.5 0.3 -0.8 -1.5 0.2 0.5
Breast Cancer 1.8 4.4 12.6 -1.8 -0.5 3.6 -1.6 -2.7 -1.9 -1.1
Ovarian Cancer 3.0 4.0 7.5 1.8 1.6 -1.5 1.3 -1.9 2.7 2.7
Prostate Cancer 0.1 0.2 0.5 0.2 0.3 -0.5 -0.7 0.2 0.3 0.7
Age at First Birth 1.3 1.9 3.9 1.1 1.9 -0.6 2.0 0.3 1.0 1.8
Bipolar Disorder (2011) 4.6 4.4 8.4 1.6 2.1 -2.2 1.4 -0.9 2.9 2.8
Body Mass Index (BMI) (2010) 1.5 2.0 3.9 -0.9 -1.8 -0.3 -1.7 2.0 -1.1 -1.5
Coronary Artery Disease (CAD) 0.8 1.0 2.2 -0.9 -0.5 0.2 -1.5 1.2 -0.8 -1.1
Crohns Disease (2012) 0.5 0.8 1.8 0.3 -0.3 -0.5 0.8 -1.2 1.3 1.3
Mean Putamen Volume 0.5 0.6 1.8 -1.0 -1.3 0.6 -0.7 -0.6 0.0 0.3
Fasting Glucose 0.3 0.4 0.9 0.6 1.0 -0.2 -0.9 -0.3 0.6 0.3
HbA1C 0.3 0.3 1.5 0.0 0.1 0.3 0.1 -1.2 0.5 0.4
HDL Cholesterol 0.7 1.1 2.2 1.1 1.5 -0.7 1.1 0.5 1.0 1.1
LDL Cholesterol 0.8 1.2 4.8 0.5 -0.8 -2.2 -0.9 1.2 0.8 0.4
Lupus 0.8 1.2 3.0 -1.0 -0.9 1.2 -0.7 0.4 -1.7 -1.3
Neuroticism (2016) 0.9 1.2 2.4 1.5 1.4 -0.9 0.9 0.5 1.3 1.1
Primary Biliary Cirrhosis 0.4 0.5 1.1 0.4 -0.0 -1.0 0.8 0.2 0.8 1.0
Rheumatoid Arthritis 1.1 1.5 3.5 1.9 1.1 -0.5 1.9 -0.2 1.3 0.6
Schizophrenia (2014) 2.2 4.9 7.8 2.7 0.8 -2.7 2.1 1.5 2.8 2.3
Triglycerides 0.3 0.6 1.5 0.7 -0.0 -0.7 -1.2 1.2 0.3 -0.0
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.2 0.4 0.0 -0.3 -0.5 1.1 0.1 0.5
Ulcerative Colitis 1.2 1.7 3.9 -0.6 0.8 2.0 1.2 -1.6 -1.4 -1.0
Blood Eosinophil Count 0.7 5.5 12.6 -1.5 -0.4 3.5 -1.7 -0.7 -2.9 -3.4
Blood Platelet Count 1.5 16.9 46.2 3.7 0.5 -6.8 1.9 2.4 5.4 4.3
Blood Red Count 0.7 7.1 18.7 1.2 3.0 4.3 2.9 -2.8 -1.4 -1.4
Blood White Count 1.3 9.4 17.2 -2.6 -1.4 4.2 -2.9 -0.4 -3.8 -4.0
Heel T-Score 0.8 6.0 27.4 -2.0 -5.2 1.3 -2.6 0.1 -1.3 -0.7
BMI 1.5 8.8 21.3 -1.8 -3.6 -0.4 -1.4 4.6 -2.9 -3.7
Height 0.1 1.8 8.6 0.1 2.9 -0.3 1.8 0.3 -0.2 -0.7
Waist Hip Ratio (WHR) 0.3 1.5 4.1 -0.4 -0.5 -2.0 -1.8 1.3 0.6 0.6
Systolic Blood Pressure 0.2 0.8 2.7 0.5 1.1 0.0 0.9 -1.6 0.8 0.5
Smoking Status 0.9 2.2 7.1 -1.7 -2.0 0.7 -2.7 -0.3 -0.7 -0.8
Allergy or Eczema 0.3 0.8 2.7 0.2 1.6 0.4 0.2 -1.6 0.4 0.3
Cardiovascular Disease 0.5 1.5 3.8 -2.0 -1.0 -0.0 -1.3 0.6 -1.4 -1.4
Hypothyroidism (self reported) 2.0 4.6 8.3 1.8 1.9 -1.7 2.9 -1.5 2.2 2.7
Respiratory disease 0.3 0.7 1.7 -0.1 1.1 1.3 -0.5 0.6 -0.5 -1.2
Type 2 Diabetes (T2D) (2018) 2.1 3.9 7.2 -1.7 -2.3 1.4 -2.1 -0.2 -2.3 -2.7
Lung FEV1/FVC ratio 0.1 0.7 3.0 0.7 1.7 -0.5 0.5 0.4 0.6 0.3
Lung FVC 0.2 1.1 2.0 1.0 0.2 -0.9 1.3 1.4 0.7 1.4
Neuroticism 1.2 2.8 5.2 2.1 2.1 -1.6 0.7 0.9 2.3 1.4
Chronotype (morning person) 0.4 0.8 1.8 -1.0 -0.8 1.0 -0.3 0.3 -1.3 -1.1
Hair Pigment 0.0 0.6 1.7 -0.9 -1.3 -0.8 -0.4 0.8 -0.4 -0.6
Tanning 0.1 0.6 2.3 -0.3 0.2 0.6 -0.6 -1.5 0.5 1.0
Hand grip strength (left) 0.8 2.1 6.8 1.6 1.2 -0.4 2.6 1.6 -0.2 -0.9
Number of treatments/medications taken 0.6 1.1 2.3 -1.0 0.2 1.3 -0.6 -0.7 -1.5 -1.4
Average weekly spirits intake 0.7 0.8 3.3 -0.1 -0.7 0.5 -1.3 -1.8 0.0 0.5
Sensitivity / hurt feelings 2.4 4.2 7.4 2.4 1.7 -2.7 1.5 0.4 2.7 1.9
Frequency of depressed mood in last 2 weeks 1.1 1.6 3.8 0.8 1.3 -1.4 0.7 -0.2 1.6 2.0
Hearing difficulty/problems: Yes 0.7 1.1 5.3 -0.3 -0.4 0.3 -2.3 -0.7 0.4 1.2
Relative age of first facial hair 0.2 0.4 1.0 -0.3 -0.1 0.2 0.8 0.8 -0.5 -1.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.8 -0.5 0.1 -0.1 0.4 1.1 -0.4 -1.4
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.0 -0.0 -0.4 -0.0 -1.0 -0.7 0.6 0.8
Ever had hysterectomy (womb removed) 0.1 0.1 0.3 -0.0 -0.5 0.3 -0.6 0.3 -0.1 -0.5
Systolic blood pressure, automated reading 0.5 1.5 3.0 1.3 1.0 -1.0 1.7 -0.8 1.2 1.3
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 3.3 -0.8 0.1 1.8 -0.9 -1.3 -1.5 -1.3
Angina 0.8 1.1 4.2 -0.6 0.1 0.7 -2.0 -1.4 -0.2 -0.6
Medication for hormone replacement therapy 0.7 0.8 2.2 0.6 -1.5 -0.9 -0.9 0.3 1.0 0.4
Vitamin and mineral supplements 0.4 0.6 2.0 0.5 -0.2 0.1 0.8 1.4 -0.1 -1.1
Supplements: Zinc 0.3 0.3 0.9 0.5 -0.4 -0.9 0.5 0.5 0.6 -0.0
Medication: Co-codamol 1.3 1.6 3.4 -1.5 -1.2 0.3 -1.8 0.9 -1.0 -1.4
Medication: Metformin 2.6 3.7 9.4 -1.6 -1.4 1.2 -1.3 1.7 -2.5 -3.1
Diabetes (father) 0.8 1.0 2.7 -0.3 -0.1 0.8 1.2 1.0 -1.1 -1.6
Diabetes (mother) 1.9 2.5 4.5 -1.7 -0.6 1.8 -1.4 -0.2 -2.1 -2.1
Severe depression (siblings) 1.9 2.1 4.9 1.1 1.2 -1.1 1.2 -0.5 2.2 2.0
Pack years adult smoking proportion 0.5 0.7 3.0 -0.4 -1.0 -0.2 -1.7 0.7 -0.2 -0.4
Impedance of leg (right) 2.3 11.0 19.2 3.5 4.4 -2.0 2.4 -1.6 4.1 4.1
Leg fat-free mass (left) 1.1 5.6 10.8 -2.1 -2.8 -0.0 -1.2 2.9 -2.5 -3.3
Trunk fat percentage 0.4 1.5 5.9 1.1 -0.5 -1.3 0.5 2.4 0.5 -0.9
Hand grip strength (right) 0.4 1.2 4.8 1.3 0.6 -0.5 2.2 0.9 -0.1 -0.5
Townsend deprivation index at recruitment 0.4 0.6 1.7 -0.5 -0.7 -0.3 -0.6 -0.3 1.0 1.3
Current tobacco smoking 1.0 1.6 6.7 -0.6 -1.0 0.7 -2.6 -1.5 0.2 -0.3
Average weekly fortified wine intake 0.8 1.0 2.7 0.9 1.7 0.1 1.6 -0.4 0.4 0.6
Maternal smoking around birth 0.5 0.7 2.5 -0.4 -0.6 1.6 -0.5 -1.0 -0.5 0.5
Fed-up feelings 1.0 1.9 4.0 1.6 1.5 -1.2 -0.0 -0.7 2.0 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 2.0 1.3 1.2 -0.6 1.1 -0.2 1.4 1.4
Relative age voice broke 1.0 1.5 3.4 -1.5 -1.8 0.8 -0.7 -0.2 -1.1 -1.6
Taking other prescription medications 0.3 0.5 1.2 0.2 0.8 0.6 -0.9 -0.1 -0.4 -1.1
Age when periods started (menarche) 0.3 0.7 1.6 -1.3 -1.1 0.2 0.0 0.1 -0.8 -1.2
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.6 -0.4 -0.7 -0.2 -1.1 -1.3 0.3 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 4.2 -0.2 -2.1 0.2 -1.2 0.5 -0.6 -0.2
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.9 -1.0 -0.2 0.6 -0.4 0.4 -0.8 -0.7
Qualifications: CSEs or equivalent 0.3 0.4 1.0 1.0 1.0 0.3 0.3 0.4 0.4 0.1
Serious illness, injury or assault to yourself 0.3 0.4 0.8 -0.8 0.1 -0.0 -0.0 0.6 -0.9 -0.8
High blood pressure 0.1 0.4 1.5 -1.2 -0.4 -0.0 -0.8 -0.5 -0.4 -0.1
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.4 -0.2 1.3 0.5 0.2 -1.6 -0.0 0.0
Multivitamins +/- minerals 0.8 1.0 3.7 -0.7 0.0 -0.1 -1.1 -1.9 0.3 1.2
Stomach or abdominal pain in last month 1.2 1.6 4.6 1.5 2.2 -0.4 1.5 0.1 1.1 0.6
Supplements: Glucosamine 3.1 4.1 7.3 2.0 1.6 -1.9 2.6 -0.1 2.1 2.7
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.7 0.6 0.4 -0.6 -0.1 0.2 1.3 1.3
Medication: Atenolol 0.6 0.8 2.9 1.1 1.7 -0.2 0.5 0.8 0.4 -0.5
Medication: Levothyroxine sodium 1.4 2.3 4.1 1.1 1.2 -1.3 1.5 -1.4 1.9 2.0
Sitting height 0.2 1.1 3.9 0.4 2.0 0.4 1.5 -1.1 -0.0 -0.5
Chronic bronchitis/emphysema (father) 0.1 0.1 0.5 0.7 0.4 0.3 -0.2 -0.2 0.2 -0.1
High blood pressure (mother) 0.5 0.7 1.2 1.0 1.0 0.2 1.1 -0.8 0.5 0.9
Body mass index (BMI) 0.8 3.6 7.8 -1.1 -2.8 -0.2 -1.3 2.6 -1.6 -2.3
Impedance of leg (left) 2.2 10.5 19.7 3.2 4.4 -1.5 2.5 -2.1 3.8 3.9
Leg predicted mass (left) 1.1 5.6 10.7 -2.1 -2.8 -0.0 -1.2 3.0 -2.4 -3.3
Trunk fat mass 0.5 1.9 7.2 -0.0 -1.3 -1.1 -0.2 2.7 -0.5 -1.8
Waist circumference 0.8 2.9 10.6 -0.5 -1.8 -1.5 -0.9 3.3 -0.7 -1.6
Number of incorrect matches in round 0.3 0.4 0.9 0.8 0.9 0.1 0.1 -0.5 0.6 1.0
Past tobacco smoking 3.0 5.5 11.9 2.8 3.1 -1.9 3.4 1.0 1.8 1.4
Alcohol usually taken with meals 1.4 2.3 7.8 1.1 1.5 -1.7 2.8 1.2 0.4 0.6
Nervous feelings 1.4 2.6 8.6 1.7 2.9 -0.3 1.3 -0.4 1.5 1.5
Frequency of tenseness / restlessness in last 2 weeks 1.8 2.9 5.8 0.9 1.4 -2.0 1.1 -0.9 2.3 2.4
Hearing difficulty/problems with background noise 0.6 1.0 3.3 0.5 0.8 -0.6 -1.8 0.2 1.1 0.9
Hair/balding pattern: Pattern 2 9.7 12.3 20.6 3.6 4.2 -3.0 2.8 -1.1 4.5 4.1
Had menopause 0.8 1.0 3.3 1.0 1.3 0.4 1.8 -0.2 0.8 0.4
Had other major operations 0.6 0.7 2.3 -1.2 0.0 0.2 -1.5 -0.7 -0.5 -0.6
Forced vital capacity (FVC) 0.2 0.8 2.6 0.2 0.3 -0.7 1.4 1.6 -0.4 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 3.9 0.0 -2.0 0.2 -0.9 1.1 -0.7 -0.7
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.0 0.5 1.1 -0.1 1.4 1.1 0.1 -0.3
Qualifications: None of the above 0.4 0.8 2.2 -0.9 -1.1 0.6 -1.5 -0.8 -0.5 -0.3
Financial difficulties in last 2 years 0.2 0.3 0.7 0.2 0.4 -0.4 -0.5 0.4 0.8 0.6
Mouth/teeth dental problems 0.4 0.5 2.7 0.1 -0.7 0.1 -0.4 -1.6 -0.1 -0.7
Heart attack 0.8 1.0 2.5 -0.4 -0.7 1.1 -0.4 0.6 -1.5 -1.6
Allergy 0.1 0.3 0.5 0.5 -0.6 -0.7 -0.3 0.6 0.1 0.4
Pain all over the body in last month 0.3 0.3 1.0 -0.3 -1.0 -0.5 -0.9 -0.1 0.3 0.4
Diabetes (self-reported) 1.9 2.9 5.2 -1.6 -2.3 1.6 -1.5 -0.6 -2.0 -1.9
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.4 -0.4 0.8 0.5 1.2 -0.9 -0.4 -0.1
Medication: Ramipril 1.2 1.5 4.6 -0.6 1.0 2.1 -1.2 -1.2 -0.9 -0.9
Medication: Simvastatin 0.2 0.3 1.2 0.0 1.1 0.2 -0.2 0.4 0.2 -0.6
Fluid intelligence score 0.4 0.7 3.1 -0.8 -0.3 0.1 -1.1 -1.8 0.0 0.4
Illnesses of siblings 0.5 0.8 2.2 0.3 1.3 0.5 0.6 -1.5 -0.3 0.7
Neuroticism score 1.6 3.4 7.3 2.2 1.8 -1.7 1.0 0.2 2.7 2.1
Weight 0.7 3.6 9.3 -1.2 -2.1 -0.8 -0.8 3.1 -1.6 -2.5
Impedance of arm (right) 1.2 5.4 11.4 2.6 3.4 -1.4 1.8 -0.4 2.9 2.5
Arm fat percentage (right) 0.5 1.8 5.3 -0.3 -1.9 -0.9 -1.0 2.3 -0.4 -1.5
Trunk fat-free mass 0.6 3.4 5.9 -2.4 -2.0 -0.1 -1.4 1.4 -2.2 -2.3
Hip circumference 0.4 1.9 7.6 0.1 -0.6 -0.5 0.9 2.8 -1.0 -1.9
Time employed in main current job 0.9 1.0 1.9 -1.2 0.5 0.9 -0.8 0.1 -1.4 -1.4
Alcohol intake versus 10 years previously 0.6 0.8 3.2 0.4 0.3 1.0 -0.3 -1.8 0.6 0.9
Father’s age at death 0.7 0.9 2.9 0.2 -0.0 0.1 1.7 1.0 -0.9 -1.3
Worrier / anxious feelings 0.4 0.7 1.4 -0.7 -1.1 0.7 -1.1 -1.2 0.0 0.5
Frequency of tiredness / lethargy in last 2 weeks 1.2 1.9 3.2 1.8 1.6 -1.4 1.0 0.7 1.6 1.1
Falls in the last year 1.4 1.8 4.2 -2.0 -1.7 -0.4 -2.0 0.8 -0.8 -0.8
Hair/balding pattern: Pattern 3 1.4 2.1 7.8 -1.3 -2.8 -0.5 -1.4 1.2 -0.9 -0.8
Number of live births 1.1 1.5 3.5 -1.9 -1.7 0.3 -1.7 0.2 -1.0 -0.3
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 4.8 1.0 1.1 -0.9 2.2 1.8 0.0 0.0
Pulse rate 0.7 1.2 4.8 0.7 0.5 -1.6 -0.1 2.2 0.4 -0.3
Happiness 0.4 0.4 0.8 -0.7 -0.3 0.9 -0.3 0.4 -0.8 -0.9
Noisy workplace 0.7 0.8 1.9 -0.5 -1.0 -1.4 -0.8 1.3 0.3 -0.2
Qualifications: A levels/AS levels or equivalent 0.4 0.8 1.4 0.6 0.7 -0.7 0.7 -1.1 1.0 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.7 0.2 0.5 0.8 0.5 -0.4 -0.6 -0.1
Mouth/teeth dental problems: Dentures 0.4 0.6 3.5 -0.1 0.5 -0.6 0.4 1.9 -0.0 -0.3
Asthma 0.5 1.0 2.4 -0.6 0.6 1.6 -1.5 -0.7 -0.4 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 2.0 0.7 1.4 -0.4 1.0 0.6 0.2 0.1
Medication: Cholesterol lowering 0.7 1.0 2.9 -1.1 -0.3 1.1 -0.8 0.0 -1.0 -1.7
Depression (self-reported) 1.3 1.6 3.1 1.1 1.5 -0.7 0.8 -0.8 1.8 1.7
Medication: Lansoprazole 0.3 0.3 0.5 -0.7 -0.5 0.4 -0.7 -0.6 -0.7 -0.2
Prospective memory result 2.7 3.4 6.5 -1.3 -1.7 0.8 -1.7 2.1 -2.2 -2.5
Lung cancer (father) 2.6 3.0 9.0 1.5 0.9 -3.0 1.3 0.6 2.1 1.5
Illnesses of mother 0.5 0.7 1.8 0.6 -0.4 -1.1 -0.8 0.0 1.3 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 3.2 0.3 0.4 -0.9 1.4 1.8 -0.2 0.2
Pulse wave Arterial Stiffness index 0.5 0.6 1.8 -0.4 1.0 0.1 -0.3 1.3 -0.7 -1.0
Impedance of arm (left) 1.2 5.6 10.6 2.9 3.3 -1.4 2.3 -0.5 2.8 2.3
Arm fat mass (right) 0.7 2.9 6.5 -0.9 -2.3 -0.8 -1.1 2.5 -1.1 -2.1
Trunk predicted mass 0.6 3.4 6.0 -2.5 -2.0 -0.2 -1.4 1.5 -2.2 -2.3
Standing height 0.1 0.9 2.1 -0.5 1.4 -1.2 0.9 1.0 -0.3 -0.7
Length of working week for main job 0.5 0.5 1.3 -0.3 -1.0 -1.2 -0.8 0.6 0.4 0.2
Exposure to tobacco smoke at home 3.0 3.4 5.6 -1.4 -1.9 -0.0 -2.4 1.9 -1.9 -2.4
Breastfed as a baby 0.5 0.6 2.1 -0.4 0.5 -1.1 1.4 0.5 0.1 0.5
Tense / ‘highly strung’ 0.3 0.6 1.2 0.5 0.7 -1.1 -0.3 0.0 1.0 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 1.4 0.8 1.0 -0.5 -0.7 -0.1 1.2 1.0
Hair/balding pattern: Pattern 4 0.4 0.9 2.7 -0.6 -0.1 1.6 -0.1 0.2 -1.6 -0.9
Birth weight of first child 0.5 0.9 1.9 -1.4 -1.2 -0.6 -0.5 1.0 -0.7 -0.8
Peak expiratory flow (PEF) 0.1 0.3 1.8 -0.2 -0.1 -0.5 0.1 1.3 -0.1 -0.3
Pulse wave reflection index 1.9 2.3 3.9 1.5 2.0 -1.5 0.3 0.2 2.0 1.9
Ever highly irritable/argumentative for 2 days 0.7 0.9 1.9 1.0 0.6 -1.2 -0.1 0.4 1.4 1.1
Loud music exposure frequency 0.0 0.0 0.1 0.2 -0.1 -0.1 0.0 0.3 0.3 -0.2
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.6 -0.8 -0.2 0.6 -0.1 -0.4 -0.7 -0.4
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.2 0.0 0.9 0.5 -1.2 -1.5 0.8 1.4
Blood clot in the leg (DVT) 0.6 0.7 2.0 -0.3 -0.9 -1.4 0.6 1.3 0.2 -0.1
Medication: Paracetamol 0.6 1.1 3.7 1.2 1.9 -0.3 1.0 0.9 0.6 0.4
Headache pain in last month 2.9 4.9 12.9 2.2 3.6 -2.0 1.8 0.9 2.2 2.0
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.0 1.0 -0.0 -0.4 0.6 0.0 0.4 0.7
Glaucoma (self-reported) 0.7 0.8 2.0 0.4 1.4 -1.1 -0.0 0.9 0.8 0.9
Gout (self-reported) 0.3 0.4 1.1 -0.1 -0.8 -1.0 -0.5 1.1 0.0 -0.3
Hypothyroidism/myxoedema (self-reported) 1.3 2.6 4.2 1.3 1.7 -1.0 2.1 -1.6 1.6 1.8
Medication: Amlodipine 0.1 0.1 0.3 -0.4 -0.1 -0.6 0.3 -0.2 0.3 0.0
Medication: Ventolin 100micrograms inhaler 0.4 0.5 2.1 -0.3 1.4 0.5 0.9 0.3 -0.3 -0.1
Birth weight 0.8 1.8 3.3 1.1 1.1 -1.4 1.8 -0.2 1.3 1.8
Chronic bronchitis/emphysema (mother) 0.9 1.1 3.2 1.5 0.9 -0.3 0.6 1.8 0.7 0.6
High blood pressure (siblings) 0.3 0.4 0.9 -0.0 -0.6 -0.9 -0.2 1.0 0.8 -0.1
Forced vital capacity (FVC), Best measure 0.1 0.5 2.1 -0.4 -0.2 -0.7 0.6 1.5 -0.5 0.2
Body fat percentage 0.4 1.4 5.8 0.8 -0.7 -1.4 0.2 2.4 0.4 -0.9
Leg fat percentage (right) 0.3 1.3 3.8 0.8 -0.7 -1.7 0.2 1.9 0.9 -0.0
Arm fat-free mass (right) 0.7 3.6 6.1 -2.0 -2.3 -0.0 -1.0 1.9 -2.2 -2.5
Exposure to tobacco smoke outside home 1.2 1.6 3.0 1.2 1.2 -1.7 0.2 1.3 1.6 1.1
Comparative body size at age 10 0.6 1.7 5.1 0.3 -0.7 -2.2 0.5 0.7 1.6 1.7
Number of full brothers 0.3 0.4 1.3 -0.5 -0.4 0.2 -1.1 -0.9 0.2 0.2
Worry too long after embarrassment 1.0 1.7 3.4 1.1 1.1 -1.3 1.0 -0.5 1.8 1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.5 0.7 1.2 -0.7 0.6 0.8 0.8 0.5
Wheeze or whistling in the chest in last year 0.4 0.7 2.1 -1.0 -0.1 0.7 -1.5 -0.8 -0.0 -0.6
Number of children fathered 0.4 0.5 1.2 0.9 0.3 -0.2 0.2 -0.8 0.8 1.1
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 2.9 -1.6 -1.7 1.1 -1.5 -0.6 -0.9 -0.4
Age at first live birth 1.3 2.3 3.7 1.3 0.7 -1.1 1.6 -1.8 1.9 1.9
Pulse wave peak to peak time 0.7 0.8 1.8 0.6 -0.8 -0.4 0.5 -1.3 1.0 1.2
Health satisfaction 1.3 1.6 3.5 1.4 0.5 -1.5 1.3 1.9 1.2 0.3
Shortness of breath walking on level ground 1.2 1.5 6.0 1.3 0.5 -1.0 0.5 2.4 0.5 -1.0
Qualifications: College or University degree 0.3 0.8 2.1 -1.3 -0.7 0.4 -1.4 -0.5 -0.8 -0.3
Eye problems/disorders: None of the above 0.3 0.3 1.6 -0.2 -1.3 0.1 0.1 -0.4 0.4 0.5
Mouth/teeth dental problems: Loose teeth 2.3 2.7 5.6 -2.4 -1.7 0.7 -1.1 1.2 -2.0 -1.9
Emphysema/chronic bronchitis 0.4 0.5 1.0 0.5 1.0 -0.4 0.6 0.2 0.8 0.8
Medication for pain relief, constipation, heartburn 0.7 1.2 4.3 -1.6 -2.1 0.0 -1.0 -0.9 -0.0 0.2
Neck or shoulder pain in last month 0.7 1.0 2.9 0.2 1.5 0.8 -0.4 -1.7 0.6 0.9
Medication: Blood pressure 0.2 0.3 0.7 -0.8 0.1 0.6 -0.6 -0.5 -0.2 0.0
Angina (self-reported) 0.8 1.1 4.2 -0.5 0.0 0.7 -2.1 -1.4 -0.2 -0.6
Migraine (self-reported) 3.9 4.8 8.1 2.9 2.7 -2.2 1.9 1.5 2.3 1.6
Medication: Ibuprofen 0.8 1.0 2.4 0.8 1.5 -0.9 1.3 0.5 0.8 0.8
Medication: Allopurinol 0.9 1.2 2.0 -1.4 -1.4 0.4 -1.3 0.4 -1.0 -1.3
Medication: Omeprazole 3.3 4.0 8.1 -1.2 -2.0 2.5 -1.7 0.2 -2.3 -2.8
Medication: Seretide 50 evohaler 1.2 1.4 3.7 -1.2 0.3 1.1 -0.3 0.4 -1.7 -1.9
Mean time to correctly identify matches 0.4 0.8 3.3 0.5 1.8 -1.0 0.8 0.4 0.3 0.2
Heart disease (mother) 0.4 0.5 1.5 -1.0 -1.2 -0.2 -0.6 0.0 -0.6 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.8 0.2 1.3 0.7 0.7 -1.0 0.7 1.0
Whole body fat mass 0.6 2.4 6.8 -0.5 -1.8 -1.0 -0.7 2.6 -0.7 -2.0
Leg fat mass (right) 0.6 2.1 6.1 -0.6 -1.9 -0.9 -0.7 2.5 -0.7 -1.8
Arm predicted mass (right) 0.6 3.3 6.2 -1.9 -2.2 0.1 -0.8 1.8 -2.2 -2.5
Pulse rate, automated reading 0.1 0.5 1.2 -0.1 0.0 0.7 -0.8 -0.0 -1.0 -1.1
Alcohol intake frequency. 0.1 0.1 0.5 0.2 -0.3 -0.4 0.4 0.7 -0.0 -0.3
Comparative height size at age 10 0.4 2.3 4.4 1.3 2.1 -2.0 1.6 1.1 1.4 0.8
Number of full sisters 0.5 0.6 1.3 1.1 0.5 0.1 0.4 -0.7 1.0 0.8
Suffer from ‘nerves’ 0.7 1.1 2.5 0.9 1.6 -1.2 0.2 -0.7 1.4 1.0
Overall health rating 0.5 1.0 2.6 1.2 0.8 -1.0 0.2 1.6 1.2 0.1
Chest pain or discomfort 2.3 3.3 10.2 0.9 2.1 0.2 0.8 -3.2 1.8 2.0
Had major operations 0.6 0.7 3.1 -0.8 -0.4 0.5 -0.9 -1.8 0.2 0.2
Age at last live birth 0.9 1.3 3.0 0.9 1.0 -0.8 0.6 -1.2 1.2 1.7
Family relationship satisfaction 1.4 1.7 3.4 -1.4 -0.7 1.7 -0.3 0.1 -1.7 -1.9
Leg pain on walking 0.5 0.6 2.5 0.4 0.5 -0.4 0.9 1.6 0.0 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 0.9 -0.8 -0.5 1.0 -0.8 -0.6 -0.8 -0.6
Commuting to job workplace: Car/motor vehicle 1.3 1.5 3.6 1.9 0.3 -1.5 0.6 1.1 1.5 1.0
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.2 -1.0 -1.1 0.6 -0.4 -0.7 -0.6 -0.4
Medication: Aspirin 0.1 0.2 0.6 0.8 0.4 -0.1 -0.5 0.2 0.1 0.3
Supplements: Vitamin C 1.2 1.4 2.9 -1.5 -1.7 0.9 -0.6 -0.9 -1.4 -0.8
Knee pain experienced in last month 3.8 5.9 9.8 -2.6 -1.7 3.1 -1.8 -1.0 -3.0 -3.0
Hypertension (Self-reported) 0.1 0.3 1.1 -1.0 -0.2 -0.2 -0.8 -0.4 -0.1 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.9 2.2 4.5 -0.9 -0.7 2.1 -1.5 -1.0 -1.4 -2.1
Illnesses of father: Heart disease 0.7 1.0 2.3 0.7 0.7 -1.0 1.5 0.6 0.8 1.3
Illnesses of siblings: Diabetes 0.3 0.3 0.9 -0.7 -0.7 -0.5 0.1 0.9 -0.2 -0.2
Smoking status: Previous 0.6 1.0 1.7 -1.3 -1.3 0.9 -1.2 -0.4 -0.8 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.5 0.9 3.6 -0.3 -0.6 -1.4 -0.8 1.9 -0.1 -0.2
Whole body fat-free mass 0.8 4.6 8.5 -2.4 -2.4 0.1 -1.3 2.1 -2.5 -2.9
Leg fat-free mass (right) 1.1 6.1 11.8 -2.5 -3.0 0.4 -1.3 2.5 -2.8 -3.4
Arm fat percentage (left) 0.5 2.0 5.6 -0.2 -2.0 -0.9 -0.8 2.4 -0.5 -1.6
Average weekly red wine intake 0.4 0.5 1.4 0.5 -0.0 -0.5 -0.3 -1.1 0.6 1.2
Handedness (chirality/laterality): Left-handed 1.8 2.1 5.4 1.9 2.3 -1.0 1.6 1.3 0.5 0.3
Mood swings 1.5 2.7 6.1 0.7 1.3 -2.5 -1.0 1.2 2.1 2.0
Loneliness, isolation 0.7 1.0 1.8 1.2 1.3 -0.2 1.0 -0.3 1.1 1.1
Long-standing illness, disability or infirmity 0.3 0.5 1.6 0.4 0.8 -0.8 -0.5 1.3 0.3 -0.6
Ever had bowel cancer screening 0.6 0.7 1.3 1.0 0.8 -1.1 0.2 0.1 1.1 1.0
Diabetes diagnosed by doctor 3.0 4.9 8.4 -2.0 -2.9 1.9 -2.5 -0.5 -2.4 -2.4
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 4.1 -1.0 -0.8 0.8 -2.0 0.8 -1.1 -0.7
Friendships satisfaction 0.7 0.9 3.0 -0.2 0.2 1.7 0.8 -0.3 -0.9 -1.1
Qualifications: nursing, teaching 2.3 3.6 8.3 2.5 2.1 -0.8 2.9 -0.2 1.8 1.4
Commuting to job workplace: Walk 1.6 1.7 3.3 -1.6 -0.1 1.5 -1.4 -1.8 -1.2 -0.5
Eye problems/disorders: Cataract 0.6 0.7 1.3 -0.9 0.2 0.1 -0.2 1.1 -1.1 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 1.9 -1.2 -1.4 0.7 -0.4 -0.7 -0.4 0.6
Medication for cholesterol 0.2 0.3 1.0 0.0 0.8 0.2 1.0 0.3 0.2 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 1.7 1.0 1.0 -1.2 1.0 0.5 1.3 1.0
Back pain experienced in last month 0.9 1.2 3.6 1.0 0.9 0.8 1.3 -1.9 0.8 0.5
Mineral and other dietary supplements 1.8 2.4 4.8 -1.4 -1.8 0.9 -2.2 0.9 -1.4 -1.8
Breast cancer (self-reported) 1.4 1.7 3.0 1.2 1.6 -1.7 0.7 1.1 1.4 0.9
Asthma (self-reported) 0.5 1.1 2.4 -0.7 0.9 1.6 -1.4 -0.9 -0.3 -0.9
Osteoporosis (self-reported) 1.0 1.2 1.9 1.3 1.2 -1.3 0.3 0.6 1.4 1.1
Osteoarthritis (self-reported) 1.2 1.5 2.9 -1.5 -1.7 0.8 -1.2 -0.1 -1.4 -1.1
Medication: Aspirin 0.1 0.1 0.6 0.7 0.4 -0.0 -0.3 0.4 -0.0 -0.2
Medication: Gliclazide 1.1 1.2 1.9 -1.1 -1.0 0.9 -1.3 0.8 -1.4 -1.1
Illnesses of father: None of the above (group 1) 0.8 1.0 2.2 -1.2 0.2 1.0 -1.5 -1.2 -0.7 -0.8
Smoking status: Current 1.3 2.0 7.1 -1.0 -1.6 0.9 -2.7 -1.5 -0.2 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.8 0.8 1.0 -0.2 1.1 1.3 -0.2 -0.3
Whole body water mass 0.8 4.6 8.1 -2.4 -2.5 0.0 -1.2 2.1 -2.5 -2.9
Leg predicted mass (right) 1.2 6.2 11.7 -2.5 -3.1 0.4 -1.3 2.5 -2.8 -3.4
Arm fat mass (left) 0.7 2.8 6.7 -0.8 -2.3 -0.8 -0.9 2.6 -1.1 -2.1
Number of self-reported non-cancer illnesses 1.0 1.8 4.2 -1.6 -0.0 1.2 -2.1 -0.8 -1.0 -1.6
Average weekly champagne plus white wine intake 0.5 0.7 3.0 -1.7 -1.1 -0.2 -0.4 0.4 -0.6 -0.1
Miserableness 1.0 1.7 3.7 1.5 1.3 -1.4 0.2 1.0 1.9 1.3
Guilty feelings 2.6 3.9 7.2 2.0 1.5 -2.1 1.5 0.7 2.7 2.7
Wears glasses or contact lenses 1.1 1.2 5.8 1.3 2.4 -0.2 0.5 0.6 0.7 0.4
Ever taken oral contraceptive pill 0.3 0.4 0.8 -0.7 -0.9 0.4 0.1 0.2 -0.8 -0.6
Hearing aid user 1.5 1.7 4.4 -0.9 -1.5 0.5 -2.1 -1.8 0.0 0.9
Mother’s age at death 0.3 0.4 1.3 -0.1 0.5 1.1 0.4 -1.0 -0.6 0.3
Financial situation satisfaction 0.5 0.6 2.2 0.4 1.0 -0.4 0.3 1.5 0.4 -0.4
Tinnitus: Yes, now most or all of the time 1.1 1.3 4.4 1.0 0.2 -1.1 0.9 -0.7 1.1 2.1
Commuting to job workplace: Public transport 0.6 0.7 1.3 0.8 0.6 -1.1 1.1 0.8 0.8 0.3
Eye problems/disorders: Glaucoma 0.4 0.4 1.1 0.3 1.0 -0.0 -0.9 -0.5 0.5 0.8
Medication: Blood pressure 0.2 0.3 0.8 -0.4 -0.0 0.4 -0.6 -0.0 -0.8 -0.9
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.4 0.3 0.2 0.4 0.5 -0.6 -0.0 -0.7
Supplements: Fish oil (including cod liver oil) 1.4 1.8 4.2 1.3 1.9 -0.7 2.1 -0.5 1.2 1.1
High cholesterol (Self-reported) 0.3 0.5 1.4 -0.0 0.8 1.0 0.3 -1.2 -0.1 -0.4
Medication: Bendroflumethiazide 2.2 3.3 6.1 -1.9 -0.9 2.5 -0.9 -2.2 -2.0 -1.7
Medication: Paracetamol 0.5 0.8 2.3 1.1 1.5 -0.6 0.7 0.7 0.7 0.7
Medication: Lisinopril 0.7 0.9 2.7 -1.1 -1.1 0.1 -1.7 0.1 -0.8 -0.6
Medication: Atorvastatin 1.4 1.7 3.2 -1.6 -1.8 0.8 -0.4 0.2 -1.8 -1.5
Illnesses of father: High blood pressure 0.3 0.4 1.5 0.4 0.4 -0.1 1.2 -0.4 0.6 0.7
Alcohol drinker status: Never 0.7 0.8 1.5 -1.0 -0.2 1.1 -0.8 0.5 -1.2 -1.1
Ever smoked 2.5 4.3 11.0 -2.3 -3.0 1.3 -3.3 -0.3 -1.5 -1.0
Basal metabolic rate 0.8 4.2 7.7 -2.1 -2.4 -0.3 -1.1 2.5 -2.2 -2.8
Leg fat percentage (left) 0.2 0.9 3.1 0.5 -0.8 -1.3 0.0 1.8 0.5 -0.4
Arm fat-free mass (left) 0.6 2.9 5.3 -1.7 -1.8 -0.5 -0.6 2.3 -1.8 -2.2
Number of operations (self-reported) 2.4 3.5 6.8 -2.5 -1.4 1.8 -2.6 -0.8 -1.8 -1.6
Average weekly beer plus cider intake 0.3 0.4 1.3 -0.8 0.1 1.1 -0.2 -1.0 -0.4 0.1
Irritability 0.2 0.4 1.3 -0.4 -1.1 0.1 -1.1 0.2 -0.1 -0.2
Risk taking 0.6 0.8 5.4 -0.3 0.1 -0.2 -0.2 2.3 -0.4 0.0
Ever had prostate specific antigen (PSA) test 4.8 5.6 10.0 1.9 2.6 -1.7 2.4 -1.8 2.6 3.2
Fractured/broken bones in last 5 years 0.8 1.0 2.8 -0.6 0.3 -1.0 -0.5 -1.0 1.2 1.7
Age started oral contraceptive pill 0.5 0.7 2.3 -0.8 -0.6 0.8 0.1 -1.5 -0.8 -0.0
Diastolic blood pressure, automated reading 0.8 2.5 3.5 1.9 1.7 -1.7 1.7 1.1 1.4 1.3
Ever depressed for a whole week 0.3 0.4 0.9 -0.0 -0.1 1.0 0.9 -0.7 -0.4 -0.2
Unable to work because of sickness or disability 0.9 1.2 4.4 -1.1 -1.2 0.6 -2.1 -0.3 -0.3 -0.6
Commuting to job workplace: Cycle 3.8 4.6 8.7 -3.0 -2.3 1.6 -2.6 -2.6 -1.3 -0.6
Myopia 0.3 0.4 0.9 0.1 0.4 -0.9 0.4 -0.7 0.9 0.7
Vascular/heart problems diagnosed by doctor 0.1 0.4 1.2 1.1 0.1 -0.0 1.0 0.7 0.3 0.1
Cholesterol lowering medication 0.1 0.2 1.0 0.1 -0.4 -1.0 0.0 -0.0 0.2 -0.1
Medication: Omeprazole (e.g. Zanprol) 3.8 4.7 13.1 -1.3 -1.3 3.6 -1.3 -1.3 -2.5 -2.5
Pain experienced in last month 0.3 0.5 2.5 -0.1 -1.6 -0.5 -0.3 0.7 -0.2 0.2
Supplements: Calcium 0.4 0.4 1.1 0.0 0.8 0.4 0.9 -0.1 -0.1 -1.1
Basal cell carcinoma (self-reported) 0.8 0.9 1.8 1.1 0.6 -1.3 0.7 0.1 1.1 1.2
Heart attack/myocardial infarction (self-reported) 0.8 1.0 2.5 -0.3 -0.8 1.1 -0.3 0.6 -1.5 -1.6
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.5 -0.3 -1.1 -1.4 0.4 1.6 0.1 -0.2
Heart disease (siblings) 0.9 1.1 3.2 -0.3 -1.8 -1.7 -0.7 0.6 0.7 0.4
Alcohol drinker status: Previous 0.2 0.3 0.4 0.5 0.7 -0.6 0.1 -0.6 0.6 0.5
Pack years of smoking 0.3 0.5 2.2 -0.1 -0.5 -0.0 -1.5 0.7 -0.1 -0.4
Impedance of whole body 2.1 10.6 20.1 3.7 4.5 -1.8 3.1 -1.0 3.8 3.5
Leg fat mass (left) 0.5 2.1 5.9 -0.6 -1.9 -0.9 -0.6 2.4 -0.7 -1.8
Arm predicted mass (left) 0.6 2.8 5.3 -1.6 -1.9 -0.6 -0.6 2.3 -1.7 -2.1