Best TWAS P=2.44e-11 · Best GWAS P=5.01e-13 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | APLNR | 0.07 | 0.01 | enet | 29 | 0.04 | 1.6e-05 | -1.5 | 5.6 | 2.8e-08 | 0.44 | 0.27 | 0.35 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | LRRC55 | 0.05 | 0.02 | blup | 439 | 0.03 | 5.1e-05 | -1.7 | 6.7 | 2.4e-11 | 0.34 | 0.53 | 0.08 | TRUE |
| 3 | GTEx | Lung | YPEL4 | 0.05 | 0.06 | lasso | 3 | 0.05 | 6.7e-05 | -5.5 | 5.5 | 3.5e-08 | 0.10 | 0.93 | 0.00 | TRUE |
| 4 | GTEx | Prostate | TIMM10 | 0.45 | 0.20 | enet | 29 | 0.23 | 1.7e-06 | -4.0 | -5.2 | 1.5e-07 | -0.10 | 0.47 | 0.03 | TRUE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | YPEL4 | 0.13 | 0.05 | lasso | 6 | 0.05 | 9.0e-04 | -5.2 | 5.9 | 3.0e-09 | 0.06 | 0.47 | 0.03 | TRUE |
| 6 | GTEx | Skin Sun Exposed Lower leg | ZDHHC5 | 0.05 | 0.03 | lasso | 8 | 0.02 | 6.2e-03 | 4.8 | 5.7 | 1.5e-08 | 0.05 | 0.80 | 0.01 | TRUE |
| 7 | GTEx | Testis | MED19 | 0.16 | 0.15 | enet | 12 | 0.15 | 3.0e-07 | -5.2 | 5.2 | 2.2e-07 | 0.19 | 0.96 | 0.00 | TRUE |
| 8 | METSIM | Adipose | TIMM10 | 0.33 | 0.18 | enet | 80 | 0.22 | 1.2e-31 | -4.0 | -6.5 | 6.6e-11 | -0.02 | 1.00 | 0.00 | TRUE |
| 9 | YFS | Blood | SERPING1 | 0.04 | 0.04 | lasso | 6 | 0.04 | 1.2e-12 | 4.6 | 5.4 | 6.5e-08 | 0.00 | 1.00 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TNKS1BP1 | 0.07 | 0.05 | enet | 7 | 0.04 | 1.5e-04 | 4.7 | 6.2 | 7.6e-10 | 0.21 | 0.53 | 0.03 | TRUE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SMTNL1 | 0.08 | 0.04 | blup | 52 | 0.07 | 5.2e-14 | 3.9 | 6.1 | 1.2e-09 | 0.05 | 0.58 | 0.27 | TRUE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMX2 | 0.01 | 0.01 | enet | 7 | 0.01 | 3.3e-03 | -5.0 | 5.3 | 9.6e-08 | 0.08 | 0.02 | 0.84 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TNKS1BP1 | 0.12 | 0.02 | enet | 14 | 0.01 | 9.4e-04 | 7.2 | 5.8 | 7.8e-09 | 0.80 | 0.00 | 0.98 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | YPEL4 | 0.02 | 0.03 | lasso | 3 | 0.02 | 5.4e-06 | -5.2 | 5.4 | 7.1e-08 | 0.09 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | YPEL4 | 0.04 | 0.05 | blup | 33 | 0.04 | 2.6e-05 | -5.5 | 6.0 | 2.7e-09 | 0.07 | 0.01 | 0.99 | TRUE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMX2 | 0.03 | 0.02 | blup | 29 | 0.02 | 3.7e-03 | -5.0 | 5.7 | 1.2e-08 | 0.08 | 0.01 | 0.90 | FALSE |