Hub : Genes

TNKS1BP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue (Female)	0.0553	0.0564	2.1e-01	0.000	NA	-0.008	NA	0.068	3.1e-01	NA	6.5e-01	NA	4.6e-03
2	GTEx	Cells Transformed fibroblasts	0.0480	0.0220	5.6e-03	0.019	NA	0.016	NA	0.027	1.3e-02	NA	2.0e-02	NA	3.7e-03
3	GTEx	Spleen	0.2720	0.1010	7.4e-03	-0.008	NA	-0.011	NA	-0.004	5.8e-01	NA	7.9e-01	NA	4.1e-01
4	GTEx	Testis	0.2540	0.0680	1.7e-05	0.196	NA	0.141	NA	0.170	4.4e-09	NA	7.8e-07	NA	5.5e-08
5	TCGA	Bladder Urothelial Carcinoma	0.0690	0.0400	1.8e-04	0.045	0.042	0.043	NA	0.040	1.0e-04	0.00017	1.5e-04	NA	2.4e-04
6	TCGA	Breast Invasive Carcinoma	0.1220	0.0726	1.3e-03	0.018	0.007	0.013	NA	0.012	1.2e-04	0.01300	9.4e-04	NA	1.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.8	1.2	2.8	0.7	0.1	-1.7	1.5	-1.3	0.1
Bipolar Disorder or Schizophrenia	0.6	1.5	5.6	1.4	0.3	-0.6	2.4	0.2	-1.1
Depressed Affect (Nagel 2018)	2.2	4.5	10.2	2.0	-0.9	1.9	3.2	-1.7	-2.4
Depression (Nagel 2018)	1.4	2.1	4.7	0.5	-1.5	2.2	0.5	1.7	-1.5
Intelligence (Savage-Jansen 2018)	0.7	2.1	4.1	1.7	-1.6	-2.0	-0.5	-1.2	1.1
Neuroticism (Nagel 2018)	1.3	3.2	5.1	0.7	-0.9	2.2	2.1	-1.8	-2.3
Schizophrenia (2018)	0.7	1.5	3.2	1.2	0.3	0.6	1.8	1.2	-1.5
Schizophrenia vs Biploar Disorder	1.2	1.5	3.7	-0.5	0.4	1.7	-1.9	1.3	-0.5
Worry (Nagel 2018)	0.5	1.0	3.1	0.8	-1.0	1.8	0.3	-0.7	-0.7
Alzheimer’s Disease (in mother)	0.6	0.7	2.5	0.9	0.1	-0.0	-0.8	1.6	0.0
Alzheimer’s Disease (in father)	0.7	0.8	2.9	-0.3	-0.3	1.1	0.6	1.7	-0.1
Alzheimer’s Disease (including proxy)	0.7	1.0	2.7	1.4	-0.6	0.5	-1.0	1.6	-0.0
Crohns Disease (2017)	0.5	1.2	2.5	0.3	1.6	0.5	1.6	-0.7	-1.1
Irritable Bowel Disease (IBD)	0.5	1.1	2.4	0.9	1.5	0.2	1.4	-0.6	-1.1
Ulcerative Colitis (UC)	0.3	0.5	1.0	1.0	0.9	0.4	0.7	0.2	-0.7
Major Depression (MDD)	3.6	4.4	8.1	2.5	-2.3	-2.0	2.9	-0.7	1.4
Reaction Time	1.6	3.1	10.6	-3.2	-0.8	-2.0	0.8	-1.6	0.6
Verbal and Numeric Reasoning (VNR)	1.1	2.7	7.9	0.9	-1.4	-2.8	1.2	-0.3	2.0
Breast Cancer	0.2	0.5	1.3	0.0	-0.5	-0.9	0.4	-1.1	0.6
Ovarian Cancer	0.5	0.7	1.9	0.3	-1.0	-0.6	0.9	-0.0	1.4
Prostate Cancer	0.3	0.4	0.8	-0.5	0.3	0.9	-0.9	-0.1	0.7
Age at First Birth	0.8	1.1	1.7	-1.1	1.3	0.8	-0.8	0.9	-1.3
Bipolar Disorder (2011)	0.5	0.5	1.1	0.5	-1.0	-0.2	0.7	-0.7	-0.7
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	-0.8	1.0	0.4	0.4	0.4	-0.5
Coronary Artery Disease (CAD)	0.7	0.8	3.0	-1.7	-1.1	0.3	-0.2	0.5	-0.5
Crohns Disease (2012)	0.4	0.6	1.7	0.3	0.7	0.9	0.2	-0.6	-1.3
Mean Putamen Volume	1.0	1.1	2.4	-0.9	0.9	0.9	-1.4	0.2	-1.6
Fasting Glucose	0.7	0.8	2.1	0.1	-0.8	-1.4	0.3	0.6	1.3
HbA1C	1.8	2.0	4.9	-0.5	-0.4	-2.2	-1.8	0.4	1.8
HDL Cholesterol	1.6	2.6	7.7	1.1	-1.1	-2.8	-0.7	0.9	2.0
LDL Cholesterol	1.0	1.6	3.7	1.9	-1.7	-1.3	0.5	0.1	1.0
Lupus	1.0	1.5	4.1	-0.4	-1.2	-2.0	0.3	-0.8	1.6
Neuroticism (2016)	0.5	0.8	2.5	0.9	0.1	1.6	0.7	-0.7	-0.6
Primary Biliary Cirrhosis	0.8	1.1	2.8	-0.7	1.4	0.5	-1.7	0.4	-0.9
Rheumatoid Arthritis	0.3	0.4	1.6	-1.3	0.1	-0.7	0.6	0.4	-0.1
Schizophrenia (2014)	0.5	1.1	2.9	-0.0	0.5	0.2	1.7	1.3	-1.3
Triglycerides	0.5	0.8	2.2	-0.3	-1.1	1.1	-0.1	1.5	-0.2
Type 2 Diabetes (T2D) (2012)	0.8	1.0	2.9	-0.4	-0.1	1.2	-1.7	0.9	-0.5
Ulcerative Colitis	0.4	0.5	1.0	0.9	0.4	0.7	-0.5	0.7	-1.0
Blood Eosinophil Count	0.6	4.3	16.7	-2.7	1.1	0.4	-0.4	-4.1	-0.1
Blood Platelet Count	0.8	9.0	25.7	0.1	-2.5	-5.1	1.5	-3.7	2.5
Blood Red Count	0.2	1.8	6.1	0.0	-1.2	-0.4	2.5	1.8	0.3
Blood White Count	0.7	5.1	13.6	-2.3	-0.4	3.1	3.7	1.0	-0.5
Heel T-Score	2.2	17.2	37.8	-3.1	-3.5	-0.9	-3.1	6.2	5.8
BMI	1.5	8.5	29.9	-1.5	2.4	3.3	1.2	0.7	-5.5
Height	0.5	9.6	28.6	3.4	-1.8	-5.3	2.2	-2.6	1.6
Waist Hip Ratio (WHR)	0.5	2.3	6.9	2.6	-1.4	-0.7	1.2	1.1	1.2
Systolic Blood Pressure	1.5	7.7	15.0	0.8	3.9	3.0	-0.0	-3.2	-3.4
Smoking Status	1.7	4.0	14.4	0.7	-3.8	-2.1	0.7	1.7	1.0
Allergy or Eczema	0.8	2.2	6.1	-0.3	2.5	1.7	0.5	-0.6	-1.8
Cardiovascular Disease	2.4	7.9	20.3	-0.1	3.3	4.5	0.7	-1.0	-3.9
Hypothyroidism (self reported)	0.6	1.3	4.8	-2.2	-0.4	0.2	1.3	-1.1	-0.0
Respiratory disease	0.4	0.9	2.8	-0.7	1.7	0.0	0.7	-1.2	-0.2
Type 2 Diabetes (T2D) (2018)	0.7	1.4	3.8	-0.1	-0.3	1.9	2.0	0.6	-0.7
Lung FEV1/FVC ratio	0.1	0.7	2.8	1.7	0.4	-0.1	-0.4	-0.7	-0.4
Lung FVC	0.2	1.0	2.2	-0.7	1.5	0.7	-1.0	1.2	-0.7
Neuroticism	0.9	2.2	5.7	1.1	-1.8	1.0	2.4	-1.1	-0.9
Chronotype (morning person)	1.0	2.3	6.2	-2.5	1.1	0.6	2.4	-0.3	0.4
Hair Pigment	0.1	2.3	5.3	-1.0	-2.3	-2.3	-1.0	0.3	1.1
Tanning	0.2	1.9	6.4	-0.7	0.8	2.5	-0.4	1.2	-1.6
Hand grip strength (left)	1.2	3.1	8.1	-0.9	-1.4	0.2	-2.8	2.6	0.8
Number of treatments/medications taken	3.5	6.4	21.3	0.8	1.6	4.6	1.1	2.3	-2.7
Average weekly spirits intake	0.9	1.2	4.3	1.0	-2.1	-0.2	1.0	0.2	0.7
Sensitivity / hurt feelings	0.8	1.3	3.0	-1.1	-0.2	1.7	0.9	0.0	-1.7
Frequency of depressed mood in last 2 weeks	1.4	2.0	5.2	0.7	-1.3	2.3	0.0	0.5	-2.0
Hearing difficulty/problems: Yes	1.2	1.8	4.6	0.9	0.4	2.1	1.5	1.0	-1.5
Relative age of first facial hair	0.2	0.4	1.0	1.0	0.4	-1.0	0.3	0.2	-0.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.7	-0.1	-0.3	0.7	0.8	0.2	0.6
Ever used hormone-replacement therapy (HRT)	1.9	2.4	5.4	-1.5	0.6	2.3	0.2	2.2	-1.2
Ever had hysterectomy (womb removed)	1.9	2.2	3.9	-2.0	1.5	1.9	-0.3	0.7	-1.6
Systolic blood pressure, automated reading	1.0	2.9	6.3	0.5	2.1	2.5	-0.2	-0.7	-2.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.7	0.5	0.9	0.6	-0.2	0.2	0.4
Angina	0.8	1.0	2.1	-1.4	-0.0	1.2	1.1	-1.1	0.3
Medication for hormone replacement therapy	1.9	2.1	10.3	-0.2	1.2	0.9	-0.2	3.2	0.0
Vitamin and mineral supplements	0.4	0.6	1.3	1.1	1.0	-0.4	0.8	-0.5	-0.3
Supplements: Zinc	2.3	2.5	7.4	1.7	-1.0	-0.4	-1.6	2.7	1.0
Medication: Co-codamol	0.3	0.3	0.9	-0.7	0.9	0.2	0.8	-0.1	0.0
Medication: Metformin	0.7	1.0	2.6	0.2	-1.2	1.4	1.6	0.3	0.1
Diabetes (father)	1.4	1.7	4.0	-1.0	1.5	2.0	1.4	-0.2	-1.0
Diabetes (mother)	0.7	0.9	1.4	1.2	-1.0	-1.2	1.2	-0.5	-0.2
Severe depression (siblings)	0.7	0.8	2.6	1.6	-0.6	-0.3	-0.9	0.7	0.7
Pack years adult smoking proportion	1.2	1.8	2.6	1.5	-1.6	-1.5	1.3	0.8	1.1
Impedance of leg (right)	0.8	3.7	9.6	2.6	-1.8	-1.3	0.5	-0.6	3.1
Leg fat-free mass (left)	0.4	2.1	9.3	-0.7	1.0	0.2	1.3	-0.5	-3.1
Trunk fat percentage	1.5	5.8	18.1	-1.9	2.3	2.4	1.3	0.9	-4.3
Hand grip strength (right)	0.6	1.7	4.6	-0.2	-0.1	1.0	-2.1	2.1	-0.3
Townsend deprivation index at recruitment	0.2	0.3	1.2	1.1	-0.4	-0.1	0.1	-0.5	-0.6
Current tobacco smoking	1.7	2.7	6.0	1.4	-2.5	-1.0	1.2	2.1	1.2
Average weekly fortified wine intake	1.9	2.3	8.6	-2.9	-1.4	-0.7	0.2	0.6	1.5
Maternal smoking around birth	0.4	0.6	1.6	0.7	0.0	1.3	1.0	0.2	-0.7
Fed-up feelings	2.8	5.1	12.0	1.6	0.4	1.6	3.5	-1.9	-3.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.3	10.8	-0.2	-1.2	3.3	-1.2	1.9	-1.6
Relative age voice broke	0.7	1.0	3.0	0.8	0.6	-0.4	-1.7	0.7	1.2
Taking other prescription medications	2.5	3.8	10.5	-0.2	1.6	3.2	0.6	2.1	-2.2
Age when periods started (menarche)	0.4	1.0	4.1	-0.2	-1.2	0.1	-2.0	0.3	0.3
Bilateral oophorectomy (both ovaries removed)	2.1	2.4	4.8	-1.0	1.9	2.2	1.4	-0.3	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	3.0	6.9	15.4	-1.0	-2.8	0.2	-2.1	3.5	3.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.0	1.4	-0.3	0.6	-1.0	-0.1	-0.5
Qualifications: CSEs or equivalent	1.2	1.6	3.9	1.1	1.3	0.6	0.1	-2.0	-1.5
Serious illness, injury or assault to yourself	1.5	1.8	5.3	-1.0	0.1	2.3	0.9	1.4	-1.3
High blood pressure	3.6	10.1	26.5	-0.6	3.9	5.2	0.7	-0.0	-4.2
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.1	0.3	1.8	1.5	0.6	-1.0	-1.4
Multivitamins +/- minerals	1.0	1.2	3.4	-0.2	-1.8	1.1	-1.2	1.0	0.3
Stomach or abdominal pain in last month	1.3	1.6	5.7	1.7	-0.0	-0.6	2.4	0.3	0.6
Supplements: Glucosamine	0.3	0.4	1.2	0.7	-0.4	-0.2	-1.1	-0.5	0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.4	0.0	-0.4	0.1	0.9	1.2	0.1
Medication: Atenolol	1.2	1.5	5.7	1.3	0.8	2.4	0.1	0.2	-1.1
Medication: Levothyroxine sodium	0.3	0.5	1.1	-1.0	0.3	1.0	0.7	-0.0	-0.6
Sitting height	0.4	2.8	7.4	1.8	-0.3	-2.7	1.2	-1.9	0.9
Chronic bronchitis/emphysema (father)	0.2	0.2	0.7	-0.3	0.5	-0.1	0.1	0.8	-0.4
High blood pressure (mother)	1.0	1.3	4.8	0.4	1.0	2.2	-0.2	0.5	-1.3
Body mass index (BMI)	1.9	8.2	24.2	-2.3	2.6	3.2	0.8	1.3	-4.9
Impedance of leg (left)	0.7	3.5	9.6	2.4	-2.0	-1.1	0.8	-0.3	3.1
Leg predicted mass (left)	0.4	2.0	9.1	-0.7	1.0	0.2	1.2	-0.5	-3.0
Trunk fat mass	1.3	5.6	18.7	-1.6	2.1	2.2	1.6	0.8	-4.3
Waist circumference	1.0	3.8	11.7	-0.9	1.3	2.0	1.7	1.1	-3.4
Number of incorrect matches in round	1.1	1.8	9.5	-3.1	-0.4	0.4	1.0	-0.3	-0.1
Past tobacco smoking	0.8	1.5	3.7	-0.4	1.9	1.9	-1.0	0.0	-0.8
Alcohol usually taken with meals	0.6	0.9	2.7	-1.0	-1.0	0.1	-0.8	-0.4	1.6
Nervous feelings	0.4	0.7	1.4	0.4	0.6	1.2	0.6	-1.1	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	3.3	0.1	0.0	1.6	1.4	-0.2	-1.8
Hearing difficulty/problems with background noise	0.5	0.8	3.3	-0.3	0.2	1.8	1.1	-0.3	-0.4
Hair/balding pattern: Pattern 2	2.1	2.6	6.9	1.1	-0.9	0.2	-2.4	2.6	1.0
Had menopause	0.6	0.7	2.4	-1.6	-0.4	-0.4	0.9	0.9	0.2
Had other major operations	0.4	0.4	1.9	-1.4	-0.2	0.7	-0.3	0.0	-0.2
Forced vital capacity (FVC)	0.1	0.4	0.7	0.9	0.3	-0.8	0.6	-0.8	0.1
Heel bone mineral density (BMD) T-score, automated (right)	3.6	8.1	17.6	-1.0	-3.1	0.6	-2.1	3.9	4.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.8	0.9	-0.3	-0.7	0.1	0.3	-0.2
Qualifications: None of the above	1.5	3.2	11.8	0.1	-1.0	3.4	0.0	2.2	-1.3
Financial difficulties in last 2 years	0.5	0.7	2.3	0.4	0.1	0.9	-0.9	1.5	-0.4
Mouth/teeth dental problems	0.5	0.7	2.6	-0.3	0.8	0.3	-0.7	-1.6	-0.7
Heart attack	0.9	1.2	2.6	-0.4	-1.2	-1.3	0.5	-1.1	1.6
Allergy	1.0	2.4	6.9	0.2	-2.6	-0.8	-0.7	1.7	1.8
Pain all over the body in last month	0.6	0.6	2.6	-0.7	0.5	0.5	1.6	0.2	-0.3
Diabetes (self-reported)	0.2	0.3	0.9	-0.3	-0.3	0.7	1.0	-0.0	-0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.8	-0.1	0.8	1.4	0.7	0.1	-0.9
Medication: Ramipril	2.6	3.4	15.8	-0.1	0.9	4.0	-0.3	-0.4	-1.9
Medication: Simvastatin	0.5	0.7	1.5	0.3	-0.1	1.0	1.2	1.2	-0.0
Fluid intelligence score	0.7	1.4	3.5	0.9	-0.2	-1.9	1.4	-1.1	1.1
Illnesses of siblings	0.7	1.0	1.6	0.6	-0.9	-1.1	-1.2	-0.8	1.1
Neuroticism score	1.2	2.5	5.0	1.1	-1.8	2.2	1.9	-0.2	-1.3
Weight	0.7	3.7	14.7	-0.8	1.4	1.4	1.6	0.3	-3.8
Impedance of arm (right)	0.3	1.4	3.1	1.8	-0.7	-0.8	-1.0	-1.1	1.4
Arm fat percentage (right)	2.0	7.8	21.3	-2.2	2.7	3.2	0.6	1.4	-4.6
Trunk fat-free mass	0.1	0.8	2.3	0.7	-0.6	-0.6	1.5	-0.3	-1.1
Hip circumference	1.2	5.4	21.4	-1.2	1.9	1.8	1.5	-0.4	-4.6
Time employed in main current job	0.7	0.8	2.3	-1.5	0.7	0.8	0.1	1.1	0.1
Alcohol intake versus 10 years previously	1.2	1.9	5.2	-2.3	-1.0	0.7	-0.3	1.8	1.1
Father’s age at death	1.0	1.3	3.0	-1.7	-0.1	-1.2	-0.6	-0.6	1.7
Worrier / anxious feelings	0.9	1.6	4.8	0.4	-0.2	2.2	1.6	0.3	-1.4
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	6.9	0.9	-0.6	2.6	0.6	1.6	-1.8
Falls in the last year	0.9	1.2	3.4	-0.9	1.8	1.4	-0.5	0.6	-0.8
Hair/balding pattern: Pattern 3	0.5	0.8	3.1	-0.2	1.8	0.7	0.4	-0.6	-0.8
Number of live births	0.6	0.9	2.1	0.0	0.1	1.1	1.4	1.4	-0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.3	1.1	0.8	0.0	-0.4	-0.6	-0.3
Pulse rate	0.3	0.5	1.3	0.1	-0.2	-0.5	-1.2	1.1	0.3
Happiness	0.7	0.8	1.3	0.8	-0.8	0.8	-0.8	1.0	-1.1
Noisy workplace	0.8	1.0	3.2	0.3	-1.2	0.4	-0.0	1.8	1.0
Qualifications: A levels/AS levels or equivalent	1.2	2.7	8.6	0.2	-0.0	-2.9	-1.2	-1.4	2.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.0	0.5	-0.6	-1.0	0.3	-0.8	-0.8
Mouth/teeth dental problems: Dentures	0.8	1.4	3.2	0.0	-1.8	-0.9	1.1	1.1	1.5
Asthma	1.2	2.3	10.9	-0.7	3.3	0.5	0.5	-0.9	-1.1
Medication: Ibuprofen (e.g. Nurofen)	4.1	5.1	8.2	2.8	-2.4	1.9	-2.4	2.9	0.1
Medication: Cholesterol lowering	0.6	0.9	3.3	-0.4	0.1	1.3	1.8	-0.2	-0.3
Depression (self-reported)	0.9	1.0	2.3	-0.6	-1.2	1.5	-0.2	0.5	-1.4
Medication: Lansoprazole	1.8	2.1	7.1	-0.9	1.3	1.1	1.1	-0.6	-2.7
Prospective memory result	0.8	0.9	3.0	0.6	-0.5	0.9	1.7	1.0	-0.4
Lung cancer (father)	1.8	2.1	6.1	1.8	-1.2	-0.4	-1.0	2.5	0.9
Illnesses of mother	1.2	1.5	3.0	1.2	-1.6	-1.2	0.6	0.5	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	4.0	2.0	-0.4	-0.1	0.1	0.6	0.7
Pulse wave Arterial Stiffness index	0.4	0.5	1.3	0.5	-0.7	-1.1	0.0	-0.8	-0.3
Impedance of arm (left)	0.2	0.8	1.6	1.0	0.0	-1.0	-0.5	-1.0	1.3
Arm fat mass (right)	1.7	7.0	23.3	-1.8	2.4	2.6	1.4	0.8	-4.8
Trunk predicted mass	0.1	0.8	2.3	0.6	-0.5	-0.6	1.5	-0.3	-1.1
Standing height	0.7	6.9	14.5	2.8	-2.4	-3.8	2.2	-2.2	1.8
Length of working week for main job	1.0	1.1	2.2	1.5	-0.3	-1.1	0.9	-0.9	1.1
Exposure to tobacco smoke at home	1.1	1.2	2.1	-1.1	-1.4	1.4	1.2	0.9	0.3
Breastfed as a baby	0.6	0.8	1.7	-1.3	-0.4	0.8	-1.3	-0.7	0.1
Tense / ‘highly strung’	0.8	1.3	3.2	-0.5	-0.3	1.8	-1.5	1.4	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	7.0	2.6	-0.9	1.3	1.9	2.3	-0.8
Hair/balding pattern: Pattern 4	0.5	1.2	2.9	0.6	1.7	0.5	0.1	-0.8	-1.7
Birth weight of first child	1.5	2.7	10.2	-0.1	-0.9	-3.2	-1.1	-1.2	1.5
Peak expiratory flow (PEF)	0.4	0.9	2.1	1.4	-0.8	-0.1	-0.7	1.2	1.0
Pulse wave reflection index	0.3	0.4	0.8	0.6	-0.7	-0.4	0.4	0.5	0.9
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.0	-0.1	-0.3	1.4	-1.2	1.7	-1.2
Loud music exposure frequency	2.0	2.1	6.4	1.2	1.4	0.8	2.5	1.4	-0.8
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	7.6	0.2	-0.6	-2.8	-0.4	-0.7	1.9
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.7	-0.3	1.6	-0.2	0.3	-0.2	-1.1
Blood clot in the leg (DVT)	0.3	0.4	0.9	-0.6	-0.9	-0.6	-0.8	0.0	0.2
Medication: Paracetamol	1.1	1.8	5.8	2.0	-0.2	2.4	0.1	1.0	-0.4
Headache pain in last month	0.5	0.8	1.5	0.7	-1.0	0.3	-0.6	1.2	1.2
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	3.7	0.3	-0.9	-1.5	-1.9	0.3	1.3
Glaucoma (self-reported)	0.8	1.0	4.0	1.2	-0.1	2.0	-0.4	0.5	-0.4
Gout (self-reported)	1.5	2.0	3.2	1.8	1.7	0.2	1.6	-0.6	-1.7
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	6.3	-2.5	-0.2	1.0	0.0	-0.2	-0.1
Medication: Amlodipine	1.2	1.6	4.0	-1.3	-0.9	2.0	1.4	1.1	-0.5
Medication: Ventolin 100micrograms inhaler	0.9	1.1	3.8	-0.2	-1.2	-0.4	0.9	-1.9	0.6
Birth weight	2.2	4.8	9.3	-1.2	-3.0	-2.0	-2.6	0.9	2.5
Chronic bronchitis/emphysema (mother)	1.2	1.4	5.0	-2.2	0.2	-0.2	0.8	-1.5	0.5
High blood pressure (siblings)	1.3	1.9	3.5	-1.2	1.6	1.9	1.4	0.6	-1.4
Forced vital capacity (FVC), Best measure	0.2	0.7	2.4	1.6	-0.3	-0.7	0.7	0.2	0.7
Body fat percentage	1.7	6.7	18.8	-1.8	2.5	2.9	1.4	1.2	-4.3
Leg fat percentage (right)	1.5	5.5	12.1	-1.5	1.7	3.1	1.7	1.7	-3.5
Arm fat-free mass (right)	0.3	1.4	4.0	-0.4	0.2	-0.4	2.0	-0.3	-2.0
Exposure to tobacco smoke outside home	1.6	2.1	5.0	-1.4	-0.2	2.2	-0.0	2.2	-1.1
Comparative body size at age 10	2.1	5.7	15.1	-1.9	3.9	0.4	0.4	-0.1	-3.9
Number of full brothers	0.3	0.4	1.0	-0.0	-0.6	0.3	-1.0	1.0	0.3
Worry too long after embarrassment	1.3	2.3	8.0	-1.6	-0.3	2.8	-0.0	1.5	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.6	1.4	-0.1	1.6	1.1	1.4	0.4
Wheeze or whistling in the chest in last year	0.2	0.4	1.4	-1.2	0.7	0.8	0.4	0.2	0.2
Number of children fathered	0.2	0.3	0.9	-0.2	0.5	0.4	0.3	0.9	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	7.6	-2.8	0.4	-0.5	2.2	-0.9	-0.7
Age at first live birth	1.5	2.7	9.1	0.0	0.7	-3.0	0.8	-2.4	0.6
Pulse wave peak to peak time	0.2	0.3	0.8	-0.3	0.5	0.9	0.2	0.6	0.3
Health satisfaction	3.7	4.9	10.4	2.1	3.2	1.9	0.9	-0.2	-3.1
Shortness of breath walking on level ground	3.3	3.9	9.5	0.1	2.6	0.8	1.8	-1.8	-3.1
Qualifications: College or University degree	1.0	3.0	7.5	-1.1	1.2	-2.5	1.3	-0.7	2.7
Eye problems/disorders: None of the above	0.2	0.2	0.6	-0.0	-0.4	-0.6	-0.8	0.1	0.1
Mouth/teeth dental problems: Loose teeth	0.9	1.0	2.0	-0.9	0.4	1.4	1.4	0.9	-0.5
Emphysema/chronic bronchitis	0.5	0.6	2.4	-0.5	-0.3	-1.6	0.1	-0.3	0.6
Medication for pain relief, constipation, heartburn	1.8	3.1	9.9	-2.0	1.0	-3.1	-0.1	-1.9	0.5
Neck or shoulder pain in last month	1.3	1.9	6.3	1.8	0.1	0.9	2.5	0.2	-1.1
Medication: Blood pressure	2.3	4.1	7.4	-0.9	2.3	2.7	2.0	-0.3	-2.5
Angina (self-reported)	0.6	0.8	1.8	-1.3	-0.4	0.9	0.9	-1.1	0.4
Migraine (self-reported)	0.5	0.6	1.8	1.1	-0.8	-0.2	-1.3	-0.0	0.6
Medication: Ibuprofen	3.8	4.5	7.9	2.6	-1.9	1.8	-2.4	2.8	0.1
Medication: Allopurinol	1.8	2.4	6.1	1.5	2.5	-0.0	1.6	-0.8	-1.6
Medication: Omeprazole	1.0	1.2	3.5	1.3	-0.0	-0.0	1.3	1.9	0.7
Medication: Seretide 50 evohaler	0.6	0.7	2.2	-1.5	-0.0	-0.2	0.5	-1.1	-0.6
Mean time to correctly identify matches	1.8	3.4	13.7	-3.7	-0.9	-1.8	1.2	-1.0	0.6
Heart disease (mother)	1.6	1.9	8.3	-2.9	1.2	0.6	0.2	-0.9	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.3	4.2	-2.0	1.5	2.0	-1.4	1.1	-0.7
Whole body fat mass	1.4	5.9	19.0	-1.6	2.1	2.3	1.8	0.9	-4.4
Leg fat mass (right)	1.4	5.6	16.6	-1.6	1.9	2.5	1.8	1.2	-4.1
Arm predicted mass (right)	0.2	1.3	3.7	-0.4	-0.2	-0.3	1.9	-0.2	-1.9
Pulse rate, automated reading	0.8	2.6	9.2	1.0	-1.6	-0.9	-0.5	3.0	1.4
Alcohol intake frequency.	0.9	2.1	10.4	-3.2	0.2	0.8	0.1	0.4	-1.2
Comparative height size at age 10	0.4	1.9	4.3	-0.1	-2.1	-1.9	1.6	-0.2	1.1
Number of full sisters	0.3	0.4	1.1	-0.0	-0.2	-0.9	-0.8	-1.0	-0.2
Suffer from ‘nerves’	0.8	1.3	2.3	1.3	-0.2	1.2	-1.5	-0.7	-1.4
Overall health rating	1.5	3.2	9.2	0.9	0.9	2.7	1.0	0.0	-3.0
Chest pain or discomfort	0.9	1.2	3.3	0.5	0.5	1.8	-1.4	1.2	-0.0
Had major operations	0.8	0.9	2.0	0.1	0.5	1.1	1.4	-0.5	-1.3
Age at last live birth	1.2	1.8	4.9	1.1	0.3	-2.2	1.6	-0.6	1.1
Family relationship satisfaction	0.1	0.1	0.3	0.1	0.4	-0.0	0.2	0.5	-0.5
Leg pain on walking	1.5	1.9	4.7	0.7	2.2	0.8	-0.0	-1.0	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.1	0.4	-1.5	0.5	-0.2	1.2	-0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.2	-1.5	0.4	-0.2	-0.4	0.5	0.2
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.9	-0.6	0.9	-1.1	-0.5	-1.1	1.4
Medication: Aspirin	0.6	0.8	4.0	0.4	-0.4	2.0	-0.1	0.6	-0.2
Supplements: Vitamin C	1.2	1.4	2.3	-1.3	-1.5	0.7	-1.4	1.5	0.2
Knee pain experienced in last month	1.1	1.7	3.7	-0.4	0.9	1.6	-0.2	1.8	-1.9
Hypertension (Self-reported)	3.7	10.4	24.4	-0.9	4.2	4.9	0.7	-0.3	-4.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	3.6	0.4	-0.7	0.8	1.1	1.9	-0.4
Illnesses of father: Heart disease	1.5	2.1	6.1	1.0	0.6	2.0	-0.8	-0.3	-2.5
Illnesses of siblings: Diabetes	0.2	0.2	0.5	-0.0	0.3	0.5	0.7	0.3	-0.6
Smoking status: Previous	0.5	0.8	2.3	0.1	-0.9	-1.5	0.5	-1.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.8	0.0	-1.8	-2.2	0.1	0.4	1.8
Whole body fat-free mass	0.2	1.2	4.3	-0.0	0.1	-0.4	1.6	-0.4	-2.1
Leg fat-free mass (right)	0.4	1.9	8.2	-0.9	0.8	0.1	1.2	-0.6	-2.9
Arm fat percentage (left)	2.2	8.7	23.0	-2.5	3.1	3.2	0.7	1.5	-4.8
Average weekly red wine intake	0.8	1.2	4.8	1.0	-0.5	-0.1	-2.2	0.5	1.1
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.4	-0.2	-0.7	-0.3	0.0	-0.3	0.6
Mood swings	1.2	2.2	4.4	1.3	-0.3	1.9	1.7	-0.5	-2.1
Loneliness, isolation	0.7	1.0	2.1	0.2	-1.4	0.7	1.4	-0.7	-0.9
Long-standing illness, disability or infirmity	1.1	1.7	3.6	0.3	0.6	1.7	1.7	-0.4	-1.9
Ever had bowel cancer screening	0.3	0.4	1.8	-1.3	-0.2	0.0	-0.6	0.1	0.2
Diabetes diagnosed by doctor	0.8	1.3	4.4	0.2	-1.0	1.5	2.1	0.0	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.7	1.0	-1.0	-0.3	1.6	0.2	0.4
Friendships satisfaction	1.1	1.3	2.9	1.0	-1.0	-1.7	1.5	-0.6	-0.7
Qualifications: nursing, teaching	1.1	1.6	3.0	-0.7	1.3	-1.2	1.6	-1.7	-0.9
Commuting to job workplace: Walk	1.7	1.8	6.8	0.2	-1.3	-1.5	0.2	-2.6	-0.6
Eye problems/disorders: Cataract	1.1	1.2	3.1	-0.8	0.7	-1.3	1.2	-1.8	0.1
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.5	1.6	-0.8	1.2	-0.6	0.6	-0.2
Medication for cholesterol	3.5	5.2	16.8	0.3	-1.3	-4.1	-0.5	-3.0	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	6.0	-2.4	1.2	0.5	0.8	1.5	0.2
Back pain experienced in last month	0.6	0.9	2.2	1.4	-0.7	-0.2	0.8	1.5	0.4
Mineral and other dietary supplements	0.2	0.3	0.8	0.2	0.3	-0.8	0.9	0.4	-0.4
Breast cancer (self-reported)	1.4	1.7	4.1	-0.5	1.0	2.0	-0.3	1.4	-1.7
Asthma (self-reported)	0.9	1.8	8.2	-0.7	2.9	0.3	0.4	-1.1	-0.8
Osteoporosis (self-reported)	0.8	1.0	2.0	1.3	0.8	1.4	1.3	0.2	-0.1
Osteoarthritis (self-reported)	1.7	2.1	7.0	0.7	1.2	2.6	0.1	-0.3	-1.9
Medication: Aspirin	0.4	0.5	2.5	0.0	-0.5	1.6	-0.4	0.5	-0.0
Medication: Gliclazide	1.0	1.2	6.7	-0.4	-0.3	-0.0	2.6	-0.3	-0.1
Illnesses of father: None of the above (group 1)	0.8	1.0	3.7	-0.1	-1.0	-1.9	-0.1	0.5	0.9
Smoking status: Current	2.3	3.7	9.2	1.1	-3.0	-1.0	1.3	2.5	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.0	0.6	1.4	1.2	-0.4	1.0	-0.7
Whole body water mass	0.2	1.3	5.0	-0.0	0.2	-0.3	1.5	-0.5	-2.2
Leg predicted mass (right)	0.3	1.8	7.8	-0.9	0.8	0.0	1.2	-0.6	-2.8
Arm fat mass (left)	1.7	7.0	23.1	-2.0	2.5	2.4	1.3	0.9	-4.8
Number of self-reported non-cancer illnesses	2.6	4.5	13.8	-0.8	1.7	3.7	1.3	0.6	-2.7
Average weekly champagne plus white wine intake	0.8	1.1	2.7	1.1	0.7	-0.6	1.1	-1.6	-0.9
Miserableness	1.6	2.8	6.2	1.9	0.1	2.3	0.0	-1.3	-2.5
Guilty feelings	0.8	1.2	3.3	-0.5	0.5	1.4	1.1	0.2	-1.8
Wears glasses or contact lenses	0.6	0.7	1.7	-0.3	0.6	1.3	-1.3	0.6	-0.1
Ever taken oral contraceptive pill	1.1	1.2	3.8	1.2	-2.0	-0.3	0.3	0.8	0.9
Hearing aid user	1.7	1.9	7.9	0.1	2.8	0.4	0.6	-1.0	-1.3
Mother’s age at death	0.4	0.5	0.9	0.9	-0.6	-0.9	-0.1	0.6	0.6
Financial situation satisfaction	1.6	2.0	4.5	2.0	-0.6	2.1	-0.7	1.6	-0.6
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	0.1	0.6	-0.2	0.3	0.2	-0.0
Commuting to job workplace: Public transport	0.3	0.4	1.0	0.2	1.0	0.8	0.4	-0.4	-0.4
Eye problems/disorders: Glaucoma	0.5	0.6	1.8	1.1	0.5	1.3	-0.3	0.5	0.4
Medication: Blood pressure	3.0	5.8	21.3	-1.5	1.8	4.6	-0.0	0.3	-2.7
Pain type(s) experienced in last month: Hip pain	0.8	1.0	5.2	0.2	0.2	0.6	2.3	-0.2	-0.7
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.2	-1.0	0.3	1.5	-1.1	0.2	-0.3
High cholesterol (Self-reported)	0.7	1.2	3.8	0.5	-0.1	1.9	0.8	1.2	-1.0
Medication: Bendroflumethiazide	3.1	4.7	11.6	-0.4	3.4	3.0	1.4	-0.1	-2.4
Medication: Paracetamol	1.3	2.0	5.5	2.0	-0.3	2.4	0.3	1.3	-0.6
Medication: Lisinopril	1.5	2.0	5.3	-1.2	2.3	1.7	-0.2	1.1	-0.9
Medication: Atorvastatin	0.7	0.8	2.3	0.5	-1.2	1.0	1.5	0.2	-0.4
Illnesses of father: High blood pressure	1.4	1.7	4.7	-1.0	1.3	2.2	-0.7	-0.8	-1.3
Alcohol drinker status: Never	1.5	1.8	3.6	-1.9	0.3	1.8	-0.3	1.9	-0.4
Ever smoked	1.3	2.2	5.2	0.7	-2.3	-1.6	0.4	1.2	1.9
Basal metabolic rate	0.3	1.6	6.8	-0.1	0.4	0.1	1.6	-0.3	-2.6
Leg fat percentage (left)	1.7	6.3	12.9	-1.8	1.7	3.4	1.8	2.0	-3.6
Arm fat-free mass (left)	0.3	1.5	5.6	-0.4	0.2	0.0	1.7	-0.4	-2.4
Number of operations (self-reported)	0.6	0.8	2.4	-1.5	-0.0	1.6	-0.3	-0.3	-0.4
Average weekly beer plus cider intake	0.4	0.6	2.4	-0.6	1.5	-0.2	0.6	0.1	-0.7
Irritability	0.8	1.3	2.4	1.6	-1.1	0.1	0.8	-1.5	-1.2
Risk taking	1.8	2.6	11.2	1.1	-0.4	1.7	-0.1	3.4	0.7
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.2	0.8	-0.2	-1.2	1.5	0.1	0.5
Fractured/broken bones in last 5 years	0.4	0.5	1.4	0.3	-0.5	1.2	0.7	0.5	-0.8
Age started oral contraceptive pill	0.3	0.4	1.0	-1.0	-0.7	-0.5	0.8	-0.1	0.3
Diastolic blood pressure, automated reading	0.5	1.7	3.4	1.3	1.9	1.4	0.2	-0.2	-1.8
Ever depressed for a whole week	0.4	0.5	0.9	-0.4	-0.9	0.5	0.7	0.9	-0.4
Unable to work because of sickness or disability	1.3	1.6	4.5	-0.9	1.6	0.4	1.4	-0.2	-2.1
Commuting to job workplace: Cycle	0.5	0.6	2.5	-1.6	0.7	0.4	-0.2	0.7	0.5
Myopia	1.3	1.9	3.0	1.7	-1.6	-0.5	-0.9	1.5	1.7
Vascular/heart problems diagnosed by doctor	3.2	8.6	25.1	0.5	-3.3	-5.0	-0.8	-0.1	3.9
Cholesterol lowering medication	0.8	1.1	2.2	-0.1	-0.1	1.4	1.4	1.5	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.7	0.3	0.7	0.6	1.3	1.3	-0.2
Pain experienced in last month	0.6	1.0	4.4	-0.1	-0.1	-1.0	-0.5	-2.1	0.5
Supplements: Calcium	1.0	1.1	2.5	-1.2	-1.6	-0.8	-0.8	0.3	1.1
Basal cell carcinoma (self-reported)	0.1	0.2	0.6	-0.8	0.6	-0.3	0.1	-0.1	0.1
Heart attack/myocardial infarction (self-reported)	1.0	1.2	2.9	-0.4	-1.2	-1.4	0.3	-1.0	1.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	-0.4	-0.6	-0.3	-0.7	0.4	-0.0
Heart disease (siblings)	0.3	0.4	1.5	0.7	-0.0	0.3	0.0	0.6	-1.2
Alcohol drinker status: Previous	0.3	0.3	0.8	0.9	-0.6	-0.6	0.6	0.3	0.1
Pack years of smoking	1.3	1.8	2.8	1.4	-1.7	-1.4	1.1	1.3	1.3
Impedance of whole body	0.4	2.0	4.4	1.9	-1.0	-1.4	-0.0	-1.2	2.1
Leg fat mass (left)	1.5	5.7	16.2	-1.8	1.9	2.4	1.9	1.4	-4.0
Arm predicted mass (left)	0.3	1.4	5.0	-0.2	-0.3	0.0	1.8	-0.3	-2.2