[Hub]/) : Traits : Heel T-Score : ← →

chr14:22,600,863-25,489,283

Best TWAS P=2.56e-21 · Best GWAS P=3.38e-34 conditioned to 2.68e-23

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ADCY4	0.08	0.04	lasso	3	0.03	3.3e-03	-5.0	-6.1	9.6e-10	0.00	0.16	0.40	FALSE
2	GTEx	Brain Hippocampus	ADCY4	0.35	0.03	lasso	10	0.07	1.1e-02	-8.4	-7.4	1.6e-13	0.08	0.04	0.58	FALSE
3	GTEx	Breast Mammary Tissue	LTB4R	0.30	0.18	lasso	4	0.16	2.3e-08	-5.2	5.2	1.8e-07	0.00	0.87	0.11	FALSE
4	GTEx	Colon Transverse	ADCY4	0.26	-0.01	lasso	4	0.00	3.6e-01	-7.4	-5.4	5.7e-08	0.08	0.06	0.14	FALSE
5	GTEx	Esophagus Mucosa	TGM1	0.14	0.03	enet	21	0.03	5.1e-03	-5.0	6.2	5.7e-10	-0.01	0.10	0.82	FALSE
6	GTEx	Esophagus Mucosa	TSSK4	0.10	0.00	enet	31	0.00	1.8e-01	-8.7	5.7	1.4e-08	0.00	0.01	0.93	FALSE
7	GTEx	Heart Atrial Appendage	ADCY4	0.28	0.14	lasso	4	0.10	2.1e-05	-7.4	-7.2	4.3e-13	0.03	0.17	0.61	FALSE
8	GTEx	Lung	LTB4R	0.19	0.15	lasso	6	0.12	2.0e-09	-5.0	6.3	3.5e-10	0.00	0.98	0.02	FALSE
9	GTEx	Thyroid	ADCY4	0.13	0.13	lasso	6	0.09	1.0e-07	-8.4	-9.1	6.5e-20	0.04	0.03	0.97	FALSE
10	METSIM	Adipose	ADCY4	0.07	0.03	lasso	5	0.03	2.2e-05	-8.4	-9.5	2.6e-21	0.04	0.01	0.99	TRUE
11	METSIM	Adipose	LTB4R	0.15	0.07	blup	498	0.07	6.2e-11	-5.2	5.8	6.1e-09	0.03	0.93	0.07	FALSE
12	METSIM	Adipose	RABGGTA	0.10	0.06	lasso	9	0.08	5.5e-12	-6.7	-5.9	3.0e-09	-0.02	0.99	0.01	FALSE
13	YFS	Blood	ADCY4	0.02	0.00	bslmm	493	0.01	1.3e-04	-1.6	-5.3	1.1e-07	-0.04	0.09	0.08	FALSE
14	YFS	Blood	LTB4R	0.02	0.00	blup	483	0.01	6.1e-03	-6.7	8.2	1.6e-16	-0.01	0.03	0.95	FALSE
15	YFS	Blood	MRPL52	0.44	0.22	enet	27	0.28	2.2e-93	-8.0	6.8	7.4e-12	-0.72	1.00	0.00	TRUE
16	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ADCY4	0.03	0.01	blup	75	0.03	1.1e-03	-4.5	-7.7	1.3e-14	0.02	0.04	0.78	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADCY4	0.04	0.02	blup	75	0.04	3.8e-09	-5.1	-7.2	4.2e-13	0.05	0.07	0.93	FALSE
18	The Cancer Genome Atlas	Colon Adenocarcinoma	ADCY4	0.07	0.02	lasso	4	0.03	4.7e-03	-5.4	-7.4	1.6e-13	0.03	0.02	0.84	FALSE
19	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ADCY4	0.03	0.03	enet	5	0.03	6.9e-04	-7.7	-6.8	8.6e-12	-0.01	0.18	0.51	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADCY4	0.13	0.06	enet	20	0.09	2.8e-10	-5.1	-5.7	1.2e-08	0.06	0.38	0.62	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY4	0.06	0.06	lasso	6	0.09	3.0e-10	-8.7	-9.5	3.2e-21	0.04	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	MRPL52	0.04	0.00	blup	62	0.01	7.3e-03	-8.0	5.9	3.2e-09	-0.47	0.02	0.39	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	SLC7A7	0.17	0.05	enet	18	0.10	6.2e-12	-1.7	5.5	5.0e-08	-0.37	0.67	0.27	FALSE
24	The Cancer Genome Atlas	Lung Adenocarcinoma	ADCY4	0.07	0.09	lasso	3	0.08	4.4e-10	-5.2	-7.3	2.1e-13	0.02	0.12	0.88	FALSE
25	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ADCY4	0.05	0.05	lasso	6	0.08	3.7e-09	-4.4	-5.8	5.3e-09	-0.02	0.13	0.87	FALSE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NYNRIN	0.05	0.02	blup	81	0.02	4.0e-03	-8.0	-6.5	6.4e-11	0.02	0.02	0.85	FALSE
27	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ADCY4	0.15	0.13	lasso	6	0.12	1.2e-05	-5.1	-5.2	1.9e-07	0.03	0.10	0.34	FALSE
28	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LTB4R	0.16	0.05	blup	73	0.08	4.9e-04	-4.3	6.6	3.9e-11	-0.02	0.03	0.57	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	LTB4R2	0.04	0.00	blup	76	0.02	2.9e-03	-8.5	6.7	1.6e-11	-0.03	0.02	0.60	FALSE
30	The Cancer Genome Atlas	Stomach Adenocarcinoma	LTB4R	0.04	0.01	blup	73	0.01	4.2e-02	-8.5	7.8	6.8e-15	-0.03	0.01	0.68	FALSE
31	The Cancer Genome Atlas	Stomach Adenocarcinoma	LTB4R2	0.04	0.04	lasso	1	0.02	2.5e-02	-8.5	8.5	2.2e-17	-0.05	0.00	0.94	FALSE
32	The Cancer Genome Atlas	Thyroid Carcinoma	ADCY4	0.12	0.10	blup	75	0.12	3.6e-12	4.3	-5.9	3.5e-09	0.00	0.88	0.12	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	NFATC4	0.04	0.02	blup	66	0.02	1.1e-02	-5.1	7.5	9.5e-14	-0.06	0.02	0.72	FALSE