Hub : Genes

MRPL52

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.4010	0.0430	0.0000	0.297	0.145	0.277	0.272	0.289	1.7e-36	3.2e-17	8.6e-34	3.9e-33	1.7e-35
2	GTEx	Heart Atrial Appendage	0.2900	0.0910	0.0035	-0.003	NA	0.006	NA	0.005	4.9e-01	NA	1.6e-01	NA	1.9e-01
3	GTEx	Skin Sun Exposed Lower leg	0.1290	0.0480	0.0034	0.134	NA	0.140	NA	0.159	3.4e-11	NA	1.2e-11	NA	3.9e-13
4	YFS	Blood	0.4405	0.0340	0.0000	0.222	0.221	0.283	0.281	0.283	7.4e-71	1.1e-70	2.2e-93	1.3e-92	2.9e-93
5	TCGA	Brain Lower Grade Glioma	0.0419	0.0193	0.0044	0.004	0.015	0.008	NA	0.014	1.0e-01	7.3e-03	3.5e-02	NA	8.6e-03
6	TCGA	Thyroid Carcinoma	0.0870	0.0380	0.0038	0.018	0.027	0.014	NA	0.022	6.6e-03	1.1e-03	1.5e-02	NA	2.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.0	0.0	0.0	0.0	-0.0	-0.1	0.2	0.0	0.0
Bipolar Disorder or Schizophrenia	0.1	0.3	1.1	0.0	-0.3	0.3	0.6	0.2	-1.1
Depressed Affect (Nagel 2018)	0.5	1.1	4.0	-0.3	0.7	0.2	1.4	0.2	-2.0
Depression (Nagel 2018)	0.3	0.5	1.9	0.2	1.4	-0.1	-0.4	-0.9	0.3
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.4	0.4	-0.8	-0.2	-0.9	-1.6	-1.1
Neuroticism (Nagel 2018)	0.4	0.8	3.9	0.3	0.3	-0.1	1.0	-0.1	-2.0
Schizophrenia (2018)	0.1	0.3	0.9	0.0	-0.3	0.6	1.0	-0.3	-0.4
Schizophrenia vs Biploar Disorder	0.3	0.4	2.1	0.0	0.3	1.4	0.5	0.0	0.0
Worry (Nagel 2018)	0.3	0.6	0.9	0.9	0.9	-0.7	0.8	-0.3	-0.7
Alzheimer’s Disease (in mother)	0.5	0.6	2.3	-0.6	0.1	0.4	0.1	0.8	1.5
Alzheimer’s Disease (in father)	1.0	1.1	2.1	0.8	1.3	-1.4	-0.7	-1.2	0.6
Alzheimer’s Disease (including proxy)	0.3	0.5	1.8	0.0	0.5	-0.6	-0.5	0.5	1.4
Crohns Disease (2017)	0.5	1.1	2.4	1.3	0.3	-1.3	0.5	-0.4	1.6
Irritable Bowel Disease (IBD)	0.7	1.8	3.2	1.8	-0.6	-1.8	0.4	-0.8	1.8
Ulcerative Colitis (UC)	0.6	1.1	3.1	0.9	-1.0	-0.9	0.4	-0.7	1.8
Major Depression (MDD)	0.9	1.1	2.2	-0.8	0.9	0.3	1.5	-1.1	1.2
Reaction Time	0.8	1.6	4.4	2.1	-0.6	-2.0	0.4	0.3	-0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.0	-0.2	-0.9	0.2	-1.0	-0.4	-0.8
Breast Cancer	1.0	2.5	6.2	-1.1	-0.3	1.1	1.6	2.5	2.0
Ovarian Cancer	0.8	1.0	1.6	0.9	0.4	-1.3	-1.2	-1.3	-0.5
Prostate Cancer	2.4	3.4	7.6	-2.0	0.5	2.2	2.8	1.7	0.7
Age at First Birth	0.5	0.7	2.4	0.3	1.2	0.3	-0.1	-0.7	1.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	1.3	-1.1	-0.3	1.1	0.8	0.4	-0.9
Coronary Artery Disease (CAD)	1.2	1.4	6.8	0.0	1.3	2.6	0.0	0.0	0.0
Crohns Disease (2012)	0.9	1.5	4.3	0.0	-0.6	-1.5	1.5	0.2	2.1
Mean Putamen Volume	0.5	0.5	1.2	0.9	-0.4	-1.1	0.9	0.4	0.1
Fasting Glucose	1.6	1.9	4.1	-2.0	-0.1	2.0	1.0	1.4	0.4
HbA1C	1.0	1.1	2.8	1.7	-0.9	-1.4	-0.9	-0.6	-0.2
HDL Cholesterol	0.3	0.5	1.9	-0.4	1.0	0.0	-0.1	-0.3	1.4
LDL Cholesterol	0.9	1.4	3.9	1.6	-0.3	-2.0	0.0	-0.1	-1.2
Lupus	0.3	0.5	0.9	0.4	0.6	-1.0	0.9	0.5	-0.5
Neuroticism (2016)	0.7	1.0	4.0	0.2	2.0	-0.6	0.7	-0.6	-0.7
Primary Biliary Cirrhosis	1.0	1.4	5.5	0.0	0.1	0.5	0.9	1.4	2.3
Rheumatoid Arthritis	0.1	0.2	0.7	0.0	-0.7	-0.8	-0.0	0.0	0.0
Schizophrenia (2014)	0.1	0.2	0.5	0.0	-0.7	0.3	0.5	0.7	0.2
Triglycerides	0.9	1.5	4.7	-1.2	-0.7	1.5	2.2	-0.3	0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	0.0	0.7	-0.3	0.0	0.0	0.0
Ulcerative Colitis	0.2	0.4	1.2	0.0	-1.0	-1.1	0.0	0.0	0.0
Blood Eosinophil Count	0.2	1.8	4.3	-2.1	-1.1	1.9	-0.3	0.9	0.9
Blood Platelet Count	0.3	3.9	19.0	0.7	0.3	-0.4	-4.4	-1.8	-0.3
Blood Red Count	0.1	1.4	4.2	-1.1	-0.7	0.8	-0.5	1.2	-2.0
Blood White Count	0.1	1.0	4.8	0.3	-0.5	-0.6	-0.8	-2.2	0.4
Heel T-Score	1.9	15.1	46.9	-2.0	1.5	0.9	6.8	5.9	1.2
BMI	0.8	4.6	8.9	-2.6	-0.2	2.8	3.0	2.0	0.3
Height	0.4	8.1	29.2	-1.3	-5.4	0.7	2.5	1.6	2.9
Waist Hip Ratio (WHR)	0.8	3.6	13.5	1.2	-0.2	-1.1	-3.7	-1.9	-1.4
Systolic Blood Pressure	0.2	1.0	3.2	-0.3	-0.4	0.0	1.8	1.6	0.2
Smoking Status	0.1	0.2	0.8	0.0	-0.4	0.1	-0.5	0.9	-0.0
Allergy or Eczema	0.6	1.5	3.6	1.6	0.2	-1.9	-1.3	-0.4	1.0
Cardiovascular Disease	0.1	0.4	1.5	0.4	-0.3	-0.5	0.5	-0.1	-1.2
Hypothyroidism (self reported)	0.2	0.4	1.7	0.1	-0.9	-0.2	0.1	-0.3	1.3
Respiratory disease	1.3	2.8	5.3	1.8	0.1	-2.3	-2.3	-1.1	-1.4
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.8	-1.9	0.4	1.9	0.1	1.2	-1.3
Lung FEV1/FVC ratio	2.7	13.8	28.1	-4.7	3.2	5.3	4.0	2.5	0.5
Lung FVC	0.3	1.5	4.2	-1.4	0.2	0.8	2.0	0.9	1.0
Neuroticism	0.4	0.9	3.3	0.4	1.1	-0.5	0.3	-0.3	-1.8
Chronotype (morning person)	0.4	0.9	2.1	0.9	-0.4	-1.5	0.3	1.4	0.0
Hair Pigment	0.1	1.5	6.8	-0.8	0.8	0.6	-0.3	-0.7	2.6
Tanning	0.1	1.6	4.0	0.8	-2.0	-0.8	-1.7	-0.9	-0.5
Hand grip strength (left)	0.7	1.9	4.3	-1.9	0.3	1.6	0.8	2.1	-0.2
Number of treatments/medications taken	0.5	0.9	1.5	1.2	-0.9	-1.2	1.0	0.6	-0.1
Average weekly spirits intake	1.0	1.2	3.7	1.0	1.3	-0.6	-0.6	-1.9	0.4
Sensitivity / hurt feelings	0.2	0.3	0.9	0.2	0.7	-0.5	-0.2	-0.3	-0.9
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.6	0.6	0.8	-0.9	-1.3	-0.7	0.8
Hearing difficulty/problems: Yes	0.3	0.5	1.2	0.7	0.4	-1.1	0.8	0.1	0.9
Relative age of first facial hair	0.7	1.4	4.7	0.4	0.4	0.3	-1.7	-0.8	-2.2
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	3.7	-1.5	-0.0	1.8	1.9	1.2	0.8
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.0	-0.6	0.9	0.9	1.4	1.3	0.2
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	-0.2	-0.3	-0.4	0.8	0.7	0.6
Systolic blood pressure, automated reading	0.5	1.4	3.0	-0.4	-0.0	0.2	1.7	1.7	1.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	2.0	0.1	-0.8	0.2	-0.2	-0.3	-1.4
Angina	1.8	2.4	6.3	-1.9	-0.2	1.7	-1.1	0.2	-2.5
Medication for hormone replacement therapy	0.5	0.5	1.8	-0.7	0.4	0.3	-0.5	1.3	-0.6
Vitamin and mineral supplements	0.4	0.6	1.5	-0.4	-0.8	0.8	-0.4	1.2	-0.7
Supplements: Zinc	0.1	0.2	0.8	0.1	-0.9	-0.1	-0.1	0.0	-0.3
Medication: Co-codamol	0.5	0.6	1.1	-0.2	-0.7	-0.0	0.9	1.1	0.9
Medication: Metformin	1.1	1.6	4.7	0.4	-1.5	-0.2	1.5	0.3	-2.2
Diabetes (father)	1.1	1.3	6.3	-0.5	2.5	0.6	-0.5	0.7	-0.4
Diabetes (mother)	0.2	0.2	0.8	-0.1	0.2	0.5	0.9	-0.0	-0.3
Severe depression (siblings)	0.7	0.7	2.3	-1.5	0.7	1.2	0.3	0.1	0.2
Pack years adult smoking proportion	0.5	0.8	2.5	-0.6	0.3	0.4	1.6	1.2	-0.2
Impedance of leg (right)	1.4	6.8	16.7	3.0	-0.5	-3.1	-4.1	-1.7	-1.5
Leg fat-free mass (left)	0.9	4.6	16.2	-1.4	-2.0	1.7	4.0	0.8	1.2
Trunk fat percentage	0.8	3.0	7.2	2.2	-2.7	-2.0	-0.4	-0.7	-1.2
Hand grip strength (right)	0.7	1.9	3.7	-1.9	-1.0	1.9	-0.6	1.4	-0.6
Townsend deprivation index at recruitment	1.4	1.9	5.5	-1.9	1.1	2.3	0.3	1.0	0.3
Current tobacco smoking	0.2	0.3	1.3	0.5	0.3	-0.1	-0.2	-1.1	0.6
Average weekly fortified wine intake	1.1	1.2	4.3	-1.0	0.9	1.0	0.3	2.1	-0.6
Maternal smoking around birth	0.5	0.8	1.6	-0.5	0.7	0.9	1.2	-0.1	-1.3
Fed-up feelings	0.4	0.7	3.3	0.5	0.6	-0.1	-0.0	-0.1	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	0.7	1.1	-0.5	0.3	-0.7	0.0
Relative age voice broke	0.7	1.0	2.3	-1.2	-0.4	1.2	0.8	1.5	0.4
Taking other prescription medications	0.6	0.9	1.6	1.1	-1.2	-1.3	0.4	0.5	-0.8
Age when periods started (menarche)	0.4	0.9	2.5	-0.6	-0.5	1.0	-0.4	1.6	-1.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.0	-0.4	-0.9	0.6	1.0	1.4	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.2	-0.7	1.1	0.2	1.8	1.1	-0.8
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.0	1.4	-0.3	-1.1	0.9	1.1	-1.1
Qualifications: CSEs or equivalent	0.5	0.7	2.4	0.2	0.9	-0.8	-0.4	-0.3	-1.5
Serious illness, injury or assault to yourself	1.2	1.5	6.6	0.3	-2.6	-0.5	0.5	1.3	-0.2
High blood pressure	0.3	0.8	2.0	0.7	-1.4	-1.1	0.4	-0.7	-0.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.3	0.9	0.7	-1.1	-0.6	0.0	1.0
Multivitamins +/- minerals	0.6	0.8	2.5	-0.4	1.6	0.1	-0.9	-1.1	-0.2
Stomach or abdominal pain in last month	0.7	0.9	2.3	1.0	-1.5	-1.2	0.3	0.5	0.2
Supplements: Glucosamine	0.5	0.7	1.5	-1.2	0.9	1.2	-0.2	0.3	0.1
Diverticular disease/diverticulitis (self-reported)	1.7	2.1	5.9	1.5	1.7	-1.1	-0.2	0.2	-2.4
Medication: Atenolol	0.6	0.7	3.3	0.2	0.1	0.2	0.3	0.9	-1.8
Medication: Levothyroxine sodium	0.1	0.1	0.3	-0.2	-0.5	0.3	0.2	0.0	-0.3
Sitting height	0.5	3.8	9.9	-1.7	-2.1	1.7	3.2	0.7	1.4
Chronic bronchitis/emphysema (father)	0.9	1.1	3.6	0.6	-1.3	-0.1	-0.6	0.7	-1.9
High blood pressure (mother)	0.3	0.4	1.0	0.3	-0.8	-0.7	0.2	0.1	1.0
Body mass index (BMI)	0.4	1.7	6.5	-0.6	-1.0	0.9	2.5	1.1	0.2
Impedance of leg (left)	1.2	5.8	15.2	2.7	-0.1	-2.9	-3.9	-1.3	-1.5
Leg predicted mass (left)	0.9	4.7	16.5	-1.5	-2.0	1.8	4.1	0.9	1.3
Trunk fat mass	0.4	1.7	7.2	1.0	-2.7	-0.7	1.3	-0.0	-0.4
Waist circumference	0.3	1.2	3.9	0.4	-2.0	0.1	1.7	0.3	-0.2
Number of incorrect matches in round	0.3	0.6	1.5	0.8	-1.2	-1.0	-0.3	-0.3	-0.0
Past tobacco smoking	0.6	1.1	2.6	0.9	0.9	-1.0	0.4	-1.6	0.9
Alcohol usually taken with meals	0.3	0.5	1.3	0.5	0.1	-0.8	-0.6	-0.4	-1.2
Nervous feelings	0.9	1.6	3.4	1.7	1.1	-1.3	-0.4	-1.8	0.3
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	4.8	0.4	1.5	-0.4	2.2	0.8	1.4
Hearing difficulty/problems with background noise	0.7	1.2	3.4	0.7	-0.5	-1.8	1.6	0.1	0.8
Hair/balding pattern: Pattern 2	0.6	0.8	1.1	-1.0	1.0	1.0	-0.3	0.9	0.9
Had menopause	0.3	0.4	0.8	0.9	0.5	-0.7	-0.7	-0.2	-0.5
Had other major operations	0.3	0.4	1.3	0.0	-0.9	0.2	-0.4	1.1	0.1
Forced vital capacity (FVC)	0.6	2.2	3.6	-1.9	-0.5	1.4	1.8	0.9	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	4.4	1.2	0.6	-2.1	1.2	0.1	-0.9
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.8	0.6	0.3	-0.5	-0.3	0.1	0.9
Qualifications: None of the above	0.5	1.1	2.8	-1.0	-1.5	0.7	0.4	1.7	0.4
Financial difficulties in last 2 years	1.5	2.0	5.7	-0.5	2.3	0.4	-0.3	0.7	-2.4
Mouth/teeth dental problems	1.2	1.8	3.6	0.2	1.3	0.2	-1.5	-1.8	-1.9
Heart attack	1.1	1.5	4.3	-0.2	-1.0	0.4	-2.1	-0.1	-1.8
Allergy	0.3	0.7	1.8	-1.0	0.1	1.4	1.0	-0.2	-0.6
Pain all over the body in last month	1.1	1.2	2.9	-1.4	-1.0	1.7	0.7	1.1	0.2
Diabetes (self-reported)	0.3	0.5	0.8	-0.6	-0.4	0.7	0.8	0.9	-0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.5	0.8	-1.2	-1.2	-0.4	-0.3	0.4
Medication: Ramipril	0.8	1.0	2.9	-1.1	-0.9	0.8	-0.1	0.7	-1.7
Medication: Simvastatin	2.5	3.7	6.2	-1.3	-2.5	1.6	1.3	2.1	-2.3
Fluid intelligence score	0.2	0.4	1.1	0.3	-0.5	-0.2	-1.0	-0.7	-0.9
Illnesses of siblings	0.6	0.9	2.4	0.8	0.7	-0.6	-1.0	-1.6	0.5
Neuroticism score	0.5	1.0	2.7	0.7	1.6	-0.7	1.0	-0.4	-1.0
Weight	0.7	3.5	10.4	-0.6	-2.7	0.9	3.2	0.8	1.1
Impedance of arm (right)	2.9	13.3	39.3	3.8	-1.0	-3.8	-6.3	-3.0	-1.4
Arm fat percentage (right)	0.3	1.3	2.8	1.7	-1.4	-1.4	-0.1	-0.6	-1.0
Trunk fat-free mass	2.0	11.4	32.4	-3.4	-1.5	3.5	5.7	2.2	2.1
Hip circumference	0.9	3.8	10.1	0.1	-3.2	0.4	3.2	1.1	1.2
Time employed in main current job	0.4	0.4	2.0	0.0	0.1	0.0	-0.6	-1.4	-0.5
Alcohol intake versus 10 years previously	0.4	0.6	2.0	-0.3	-1.4	0.4	0.3	-0.1	1.0
Father’s age at death	2.6	3.4	7.7	-1.2	1.0	1.3	2.5	2.8	1.5
Worrier / anxious feelings	0.3	0.5	1.3	0.1	0.8	0.2	1.1	-0.4	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	4.4	0.3	-0.2	-0.5	2.1	0.8	0.7
Falls in the last year	0.7	0.9	3.1	-0.4	1.8	0.5	1.1	0.8	0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	-0.3	0.1	-0.2	0.9	0.7	0.6
Number of live births	1.0	1.4	3.5	0.2	1.1	-0.3	-1.7	-0.6	-1.9
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	9.1	-3.0	-0.1	2.6	2.3	1.7	1.5
Pulse rate	0.4	0.8	1.4	-1.0	-0.1	0.4	-1.1	-0.9	-1.2
Happiness	0.4	0.4	1.4	0.4	0.4	-0.7	-0.6	-0.3	1.2
Noisy workplace	0.2	0.2	0.4	0.7	0.1	-0.5	0.7	0.2	0.5
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.9	0.5	0.4	-0.2	-0.6	-1.7	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.5	-0.9	-0.8	0.6	1.2	0.4	-0.4
Mouth/teeth dental problems: Dentures	0.3	0.6	1.3	-1.1	0.1	0.7	0.9	1.0	-0.1
Asthma	0.4	0.8	2.2	0.9	-0.6	-1.5	-0.7	-0.4	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	4.3	-0.9	-0.1	1.0	1.0	0.8	2.1
Medication: Cholesterol lowering	1.9	3.0	4.4	-1.5	-2.1	1.5	0.9	2.0	-2.1
Depression (self-reported)	0.4	0.5	1.0	0.4	-0.9	-0.8	-1.0	-0.5	-0.4
Medication: Lansoprazole	0.2	0.2	0.7	0.3	-0.8	-0.2	0.1	0.6	0.3
Prospective memory result	0.8	1.0	2.3	-1.0	1.5	1.1	0.5	0.7	-0.9
Lung cancer (father)	1.1	1.3	3.8	-1.8	0.1	2.0	-0.3	0.9	-0.0
Illnesses of mother	0.7	0.8	2.9	0.8	1.1	-0.6	0.0	-0.1	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.0	10.2	-3.2	0.7	2.7	2.7	2.0	2.6
Pulse wave Arterial Stiffness index	2.8	3.3	10.2	-0.8	-2.6	0.8	1.0	0.7	3.2
Impedance of arm (left)	3.7	17.0	42.8	4.4	-1.9	-4.4	-6.5	-3.6	-2.0
Arm fat mass (right)	0.3	1.2	3.4	0.4	-1.9	-0.1	1.8	0.3	-0.2
Trunk predicted mass	1.9	10.7	31.1	-3.2	-1.5	3.4	5.6	2.0	2.1
Standing height	0.4	3.6	15.7	-0.1	-4.0	0.2	1.6	-0.2	1.8
Length of working week for main job	0.2	0.2	0.6	0.1	-0.3	0.1	-0.5	-0.8	-0.3
Exposure to tobacco smoke at home	1.0	1.1	6.3	-0.5	0.2	0.1	-0.5	-0.2	-2.5
Breastfed as a baby	0.8	1.0	2.2	0.6	0.5	-0.9	-1.3	-0.8	-1.5
Tense / ‘highly strung’	0.9	1.4	2.0	-1.0	0.9	1.3	1.2	1.4	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.6	1.3	-0.1	-1.1	-0.3	-0.8	-0.7
Hair/balding pattern: Pattern 4	0.2	0.5	1.1	-0.5	-0.9	0.8	1.0	0.2	0.3
Birth weight of first child	0.4	0.8	2.7	-0.3	1.6	-0.5	1.0	0.7	0.4
Peak expiratory flow (PEF)	1.9	4.4	13.0	-3.6	-0.7	2.7	1.3	1.5	-1.2
Pulse wave reflection index	0.4	0.5	2.2	0.7	-0.5	-0.4	-0.2	0.3	1.5
Ever highly irritable/argumentative for 2 days	0.7	0.8	3.0	0.4	-0.5	-0.1	0.3	1.1	1.7
Loud music exposure frequency	1.4	1.6	4.1	1.0	1.1	-1.3	-1.2	-2.0	0.3
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	6.0	0.3	-0.4	-0.4	-0.8	-2.3	-2.5
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.7	-0.1	-0.5	0.2	1.3	1.6	1.6
Blood clot in the leg (DVT)	0.6	0.7	2.7	0.9	-1.6	-0.6	0.2	0.6	0.2
Medication: Paracetamol	0.5	0.8	2.4	-0.1	1.1	-0.1	-1.5	-1.0	-0.1
Headache pain in last month	0.3	0.5	1.1	-1.1	-0.3	1.0	-0.5	0.5	-0.5
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	4.0	1.7	0.8	-1.4	-1.4	-2.0	1.8
Glaucoma (self-reported)	1.2	1.4	5.2	-1.1	-0.2	1.2	2.3	0.6	0.4
Gout (self-reported)	0.2	0.3	0.9	0.2	0.7	0.1	-0.9	0.4	-0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	2.1	-0.5	-1.4	0.4	0.4	0.2	0.5
Medication: Amlodipine	0.5	0.7	2.6	-0.6	-1.6	0.4	0.8	0.8	0.3
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.6	0.8	0.2	-0.8	-1.6	-0.7	0.7
Birth weight	0.6	1.2	3.8	0.6	1.5	-0.8	-0.2	0.1	2.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.1	-0.5	1.4	0.8	-0.3	-0.3	-0.6
High blood pressure (siblings)	0.6	0.9	2.0	-0.5	-0.2	0.6	1.1	1.4	-1.4
Forced vital capacity (FVC), Best measure	0.8	3.0	6.7	-2.0	0.3	1.4	2.0	1.3	2.6
Body fat percentage	0.6	2.2	4.4	2.1	-2.1	-1.8	0.1	-0.6	-1.0
Leg fat percentage (right)	0.4	1.4	3.2	1.8	-0.9	-1.5	0.9	-0.4	-1.0
Arm fat-free mass (right)	1.8	9.4	33.1	-2.7	-1.5	2.8	5.8	1.8	1.6
Exposure to tobacco smoke outside home	1.6	2.1	5.0	-1.7	-0.1	1.6	1.5	2.2	-0.3
Comparative body size at age 10	0.5	1.3	2.8	-0.9	0.5	1.3	1.7	1.3	0.9
Number of full brothers	0.2	0.2	0.7	-0.0	0.1	-0.1	0.6	-0.3	-0.8
Worry too long after embarrassment	0.5	0.8	2.9	0.9	0.4	-0.7	0.4	-0.2	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.0	1.4	-0.5	-1.0	0.6	-0.2	-0.8
Wheeze or whistling in the chest in last year	1.1	1.9	5.1	1.7	1.0	-1.5	-2.3	-0.1	-0.5
Number of children fathered	1.3	1.4	3.0	1.5	-0.3	-1.7	-1.3	-0.4	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	3.1	-1.8	0.5	1.3	0.7	0.6	0.0
Age at first live birth	1.0	1.8	3.1	-1.6	0.4	1.2	1.0	1.6	1.8
Pulse wave peak to peak time	2.4	2.8	9.5	0.8	2.1	-0.9	-0.9	-0.7	-3.1
Health satisfaction	0.8	1.1	3.6	0.4	-1.2	-0.9	1.9	0.1	0.8
Shortness of breath walking on level ground	1.5	1.8	3.1	1.5	-0.8	-1.6	0.8	1.8	-1.3
Qualifications: College or University degree	0.4	1.3	4.9	0.4	-0.5	-0.1	-1.5	-2.2	0.7
Eye problems/disorders: None of the above	1.2	1.3	4.0	0.9	-0.4	-1.4	-2.0	-0.9	-0.5
Mouth/teeth dental problems: Loose teeth	1.0	1.1	2.6	0.0	1.6	-0.7	1.6	0.9	-0.7
Emphysema/chronic bronchitis	5.6	6.3	15.6	3.4	-0.2	-3.9	-2.5	-1.1	-1.7
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	0.2	-0.4	-0.4	0.3	0.4	0.3
Neck or shoulder pain in last month	0.1	0.1	0.4	0.1	0.3	-0.3	-0.7	-0.1	0.1
Medication: Blood pressure	1.4	2.5	4.2	-2.0	-0.3	1.7	1.0	1.8	-1.9
Angina (self-reported)	1.7	2.3	6.6	-1.7	-0.4	1.5	-1.5	-0.0	-2.6
Migraine (self-reported)	1.3	1.6	3.3	-1.4	1.2	1.5	0.7	1.8	0.3
Medication: Ibuprofen	1.6	1.9	8.5	-0.8	0.5	0.7	1.1	0.5	2.9
Medication: Allopurinol	0.3	0.4	1.3	0.6	0.7	0.1	-1.1	0.5	-0.1
Medication: Omeprazole	0.2	0.3	0.9	0.1	0.4	-0.6	0.9	-0.1	-0.3
Medication: Seretide 50 evohaler	1.9	2.2	5.7	1.6	0.3	-1.7	-2.4	-0.2	-1.4
Mean time to correctly identify matches	1.0	1.8	5.0	2.1	-0.5	-2.2	0.8	0.6	-0.4
Heart disease (mother)	0.9	1.0	2.7	-0.3	-1.5	0.6	-1.0	0.1	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	4.1	0.5	-2.0	-0.8	-0.4	-0.1	-0.7
Whole body fat mass	0.4	1.5	5.8	0.8	-2.4	-0.6	1.5	-0.1	-0.2
Leg fat mass (right)	0.4	1.6	6.2	0.5	-1.8	-0.2	2.5	0.1	0.0
Arm predicted mass (right)	2.1	10.5	37.5	-2.9	-1.5	3.0	6.1	2.0	1.3
Pulse rate, automated reading	0.4	1.3	2.3	-1.5	-0.7	1.0	-1.1	-1.0	-1.3
Alcohol intake frequency.	0.2	0.4	2.0	0.4	-0.2	-0.3	-0.2	-0.4	1.4
Comparative height size at age 10	0.6	3.5	10.2	2.0	-3.2	-2.0	0.1	-1.5	0.8
Number of full sisters	0.7	0.9	2.1	1.2	0.1	-1.4	0.5	-0.7	-1.0
Suffer from ‘nerves’	0.5	0.8	3.7	0.2	0.8	0.3	0.4	-1.9	0.6
Overall health rating	0.4	1.0	2.4	-0.7	-1.2	0.3	1.5	0.8	0.9
Chest pain or discomfort	0.8	1.1	2.5	-1.1	0.4	1.6	-1.4	0.8	-0.2
Had major operations	1.0	1.2	2.6	0.6	-1.3	-0.4	1.5	0.2	1.6
Age at last live birth	0.5	0.7	1.0	-0.9	0.6	1.0	0.2	0.9	1.0
Family relationship satisfaction	0.4	0.5	2.9	-0.0	0.1	-0.2	0.4	-0.0	1.7
Leg pain on walking	0.3	0.4	1.1	0.4	-0.8	-0.5	-0.6	0.4	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.6	0.2	0.7	-0.4	0.5	0.7	-0.6
Commuting to job workplace: Car/motor vehicle	1.6	1.9	4.3	1.5	-0.1	-2.1	0.8	0.4	-2.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.9	0.6	-0.2	-0.7	-0.8	-1.0	1.4
Medication: Aspirin	0.9	1.2	5.6	0.0	-1.1	0.4	-0.5	-0.2	-2.4
Supplements: Vitamin C	0.7	0.8	2.5	-0.4	0.1	0.0	1.4	-0.0	1.6
Knee pain experienced in last month	0.4	0.7	1.5	0.5	0.8	-0.7	-1.2	0.0	1.2
Hypertension (Self-reported)	0.2	0.5	1.4	0.5	-1.2	-0.9	0.3	-0.4	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	0.6	0.6	-1.1	-0.1	-0.6	1.1
Illnesses of father: Heart disease	0.6	0.9	2.2	-0.5	-1.5	0.7	-1.2	0.8	0.5
Illnesses of siblings: Diabetes	0.6	0.7	1.5	0.7	0.7	-0.9	1.2	-0.1	-1.1
Smoking status: Previous	1.0	1.6	5.0	-1.3	-0.4	1.0	-0.5	2.2	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.5	0.3	-0.9	-0.2	1.2	-0.6	1.6
Whole body fat-free mass	1.6	9.3	29.6	-2.7	-1.8	2.9	5.4	1.8	1.9
Leg fat-free mass (right)	1.0	5.2	17.3	-1.8	-1.8	2.0	4.2	1.2	1.5
Arm fat percentage (left)	0.4	1.7	3.2	1.8	-1.7	-1.5	-0.1	-0.7	-1.1
Average weekly red wine intake	0.4	0.6	1.9	0.6	-0.1	-0.2	1.4	-0.2	-1.1
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.2	0.6	-0.2	-0.2	-1.1	-0.1	0.7
Mood swings	0.3	0.5	1.7	-0.6	1.3	0.5	0.6	-0.3	-0.2
Loneliness, isolation	0.5	0.7	1.9	0.8	-0.1	-0.9	-0.5	-1.4	-0.5
Long-standing illness, disability or infirmity	1.0	1.5	4.8	-0.8	0.2	1.1	2.2	1.4	-0.7
Ever had bowel cancer screening	1.0	1.2	2.7	-0.9	1.1	1.6	1.4	0.5	-0.6
Diabetes diagnosed by doctor	0.4	0.7	1.3	-0.8	-0.4	0.8	0.9	0.8	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.9	-1.4	-0.6	0.9	1.7	1.6	0.3
Friendships satisfaction	0.3	0.4	1.2	0.6	-0.3	-1.1	-0.5	0.4	0.6
Qualifications: nursing, teaching	0.9	1.4	3.0	0.4	1.0	-0.5	-1.4	-1.7	-1.4
Commuting to job workplace: Walk	0.4	0.4	1.2	-1.1	-0.4	0.9	-0.7	0.1	-0.3
Eye problems/disorders: Cataract	0.9	1.0	2.4	-0.9	-0.3	1.6	0.8	1.2	-0.6
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	10.8	0.3	-0.8	-0.3	0.2	0.6	3.3
Medication for cholesterol	0.5	0.8	1.3	-0.9	1.0	0.9	-1.2	-0.4	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	4.2	0.3	2.1	-0.6	-0.3	1.6	-0.7
Back pain experienced in last month	0.6	0.8	2.5	-0.9	0.4	1.1	0.4	0.5	1.6
Mineral and other dietary supplements	1.0	1.3	2.3	1.5	0.6	-1.0	-1.4	-0.4	-1.4
Breast cancer (self-reported)	1.4	1.7	8.2	0.8	-2.9	-0.5	-0.8	0.4	-0.2
Asthma (self-reported)	0.3	0.6	1.5	0.7	-1.0	-1.2	-0.6	-0.1	-0.6
Osteoporosis (self-reported)	0.9	1.2	2.9	1.2	0.9	-0.3	-0.5	-1.2	-1.7
Osteoarthritis (self-reported)	0.9	1.2	4.5	-0.3	-0.4	0.6	2.1	1.3	0.5
Medication: Aspirin	0.8	1.0	4.6	-0.1	-0.9	0.3	-0.5	-0.2	-2.1
Medication: Gliclazide	0.8	0.9	1.8	-1.1	-1.3	1.2	0.8	0.2	-0.8
Illnesses of father: None of the above (group 1)	0.5	0.7	2.2	-0.3	-0.4	0.1	0.8	-1.0	1.5
Smoking status: Current	0.2	0.3	1.0	0.4	-0.1	0.1	-0.5	-1.0	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	4.8	-2.2	1.3	1.3	2.1	1.6	1.4
Whole body water mass	1.7	9.6	30.9	-2.8	-1.8	3.0	5.6	1.8	2.0
Leg predicted mass (right)	1.0	5.4	17.9	-1.9	-1.8	2.1	4.2	1.3	1.5
Arm fat mass (left)	0.3	1.3	3.8	0.4	-1.9	-0.1	2.0	0.2	-0.3
Number of self-reported non-cancer illnesses	0.7	1.2	2.9	-0.6	-1.0	0.4	0.3	1.7	-1.6
Average weekly champagne plus white wine intake	1.2	1.6	2.7	1.6	1.4	-1.3	-1.1	-0.7	-1.3
Miserableness	0.7	1.2	4.4	0.4	1.4	-0.6	2.1	0.4	-0.8
Guilty feelings	0.9	1.3	2.7	0.4	1.7	-0.3	-0.7	-1.6	-1.3
Wears glasses or contact lenses	0.9	1.0	1.9	1.4	-1.3	-1.2	-0.7	-0.8	0.3
Ever taken oral contraceptive pill	0.6	0.7	1.4	-1.2	0.8	1.0	0.7	-0.6	0.7
Hearing aid user	1.1	1.2	2.5	1.1	1.6	-1.0	0.8	1.5	-0.1
Mother’s age at death	0.3	0.3	0.7	-0.8	-0.0	0.7	-0.4	0.2	-0.7
Financial situation satisfaction	0.6	0.7	2.6	0.6	0.3	-1.1	-0.2	-1.6	-0.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	0.3	-0.2	-0.6	-0.3	0.6	0.6
Commuting to job workplace: Public transport	0.5	0.6	1.3	0.7	-0.5	-0.5	0.4	-1.0	1.1
Eye problems/disorders: Glaucoma	1.1	1.3	6.0	-0.4	-0.4	0.5	2.5	0.7	1.0
Medication: Blood pressure	0.5	1.0	2.2	0.9	-1.5	-1.2	1.0	0.2	-0.6
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.2	0.9	0.5	-1.5	1.5	-0.1	-1.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.0	-0.9	0.0	0.7	1.4	-0.1	1.2
High cholesterol (Self-reported)	0.9	1.6	4.8	-0.9	-1.0	0.8	1.3	0.8	-2.2
Medication: Bendroflumethiazide	0.9	1.4	4.0	-0.9	-0.0	0.5	0.8	2.0	-1.6
Medication: Paracetamol	1.1	1.7	4.1	0.3	1.5	-0.9	-2.0	-1.8	-0.4
Medication: Lisinopril	0.3	0.4	1.4	-0.3	-0.0	0.4	1.2	0.8	-0.4
Medication: Atorvastatin	0.5	0.6	2.7	-0.4	0.4	-0.3	0.4	-0.2	-1.6
Illnesses of father: High blood pressure	0.2	0.2	0.6	0.1	-0.4	0.4	0.6	0.8	-0.1
Alcohol drinker status: Never	0.4	0.5	1.9	0.1	1.4	-0.4	0.6	0.6	-0.2
Ever smoked	0.3	0.5	1.3	0.1	-1.1	0.1	-0.2	0.8	-1.1
Basal metabolic rate	1.4	7.7	25.8	-2.2	-2.1	2.4	5.1	1.6	1.8
Leg fat percentage (left)	0.3	1.1	2.2	1.5	-0.6	-1.3	1.0	-0.3	-1.1
Arm fat-free mass (left)	2.0	10.0	33.9	-2.7	-1.5	2.9	5.8	2.3	1.7
Number of operations (self-reported)	0.3	0.5	1.3	0.4	-0.4	-0.6	0.8	1.1	0.4
Average weekly beer plus cider intake	1.0	1.5	3.0	1.7	-0.4	-1.6	-0.4	-1.7	-0.1
Irritability	0.0	0.1	0.3	0.5	0.0	0.2	-0.2	0.2	0.3
Risk taking	0.2	0.3	0.8	-0.2	0.9	0.2	0.8	-0.4	-0.4
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.8	1.8	-0.9	-1.9	-1.1	-0.3	-0.1
Fractured/broken bones in last 5 years	1.2	1.5	3.0	1.7	-1.7	-1.7	-0.0	-0.3	0.5
Age started oral contraceptive pill	0.2	0.3	0.8	-0.1	0.2	0.1	0.8	0.5	-0.9
Diastolic blood pressure, automated reading	0.2	0.6	2.6	-0.0	-0.5	-0.3	0.3	0.8	1.6
Ever depressed for a whole week	0.1	0.1	0.1	0.4	0.3	-0.2	-0.2	0.3	0.1
Unable to work because of sickness or disability	1.0	1.3	2.5	-1.1	-0.5	1.1	1.5	0.7	1.6
Commuting to job workplace: Cycle	0.7	0.8	2.4	-0.7	0.5	0.6	1.5	0.9	-0.7
Myopia	0.4	0.6	1.7	-1.2	-0.5	1.3	-0.1	0.5	0.1
Vascular/heart problems diagnosed by doctor	0.2	0.5	2.3	-0.1	1.5	0.4	-0.4	0.3	0.6
Cholesterol lowering medication	0.4	0.5	1.9	-0.2	-0.6	0.2	1.4	0.5	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.3	-0.2	0.5	-0.2	1.2	-0.7	-0.6
Pain experienced in last month	0.3	0.5	1.5	0.9	0.5	-1.2	0.5	-0.4	-0.5
Supplements: Calcium	0.4	0.4	1.2	-0.3	-0.2	0.6	-1.1	0.4	-1.0
Basal cell carcinoma (self-reported)	1.1	1.4	3.6	0.3	-1.9	0.0	-1.4	0.6	-1.5
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.5	-0.0	-1.1	0.2	-1.9	0.2	-1.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.1	0.5	-1.4	-0.2	0.3	1.0	0.4
Heart disease (siblings)	0.7	0.8	1.6	-1.2	-0.8	1.3	-0.1	0.8	0.8
Alcohol drinker status: Previous	1.6	1.9	5.5	1.4	-0.4	-0.9	-1.1	-2.3	1.2
Pack years of smoking	0.5	0.7	2.3	-0.5	0.3	0.2	1.5	1.1	-0.5
Impedance of whole body	2.8	14.2	35.5	4.2	-1.4	-4.3	-6.0	-2.9	-1.8
Leg fat mass (left)	0.4	1.6	6.6	0.3	-1.7	0.0	2.6	0.3	0.1
Arm predicted mass (left)	1.9	9.8	34.1	-2.7	-1.4	2.8	5.8	2.1	1.7