Hub : Genes

ESR2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0339	0.0174	8.8e-03	0.020	0.010	0.030	0.014	0.027	5.1e-04	1.2e-02	2.5e-05	0.00310	4.6e-05
2	NTR	Blood	0.0266	0.0103	9.9e-05	0.011	0.008	0.004	0.009	0.008	1.2e-04	8.3e-04	2.0e-02	0.00055	8.5e-04
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0424	0.0219	7.9e-05	0.013	0.033	0.009	NA	0.023	1.2e-02	1.0e-04	3.1e-02	NA	1.1e-03
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.1119	0.0477	1.5e-05	0.032	0.056	0.047	NA	0.039	1.3e-04	6.9e-07	4.6e-06	NA	3.0e-05
5	TCGA	Lung Squamous Cell Carcinoma	0.0238	0.0154	6.3e-03	0.004	0.010	0.003	NA	0.003	9.0e-02	2.1e-02	1.3e-01	NA	1.3e-01
6	TCGA	Testicular Germ Cell Tumors	0.1980	0.0770	7.3e-06	0.094	0.146	0.210	NA	0.164	3.4e-04	8.0e-06	5.9e-08	NA	2.0e-06
7	TCGA	Thyroid Carcinoma	0.0540	0.0280	6.2e-04	0.055	0.030	0.040	NA	0.051	4.8e-06	6.5e-04	9.0e-05	NA	9.6e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.3	0.5	1.2	-0.8	0.6	0.4	1.1	0.7	-0.6	0.3
Bipolar Disorder or Schizophrenia	0.3	0.8	1.9	0.5	-1.2	-0.7	-0.2	-1.4	-0.7	-0.8
Depressed Affect (Nagel 2018)	1.9	4.0	7.1	2.5	-2.0	-2.2	-2.0	-1.2	-0.9	-2.7
Depression (Nagel 2018)	3.3	5.0	6.8	2.3	-2.1	-2.4	-2.4	-2.2	-1.4	-2.6
Intelligence (Savage-Jansen 2018)	1.2	3.7	8.1	2.3	-1.5	-1.8	0.3	-2.8	-1.1	-2.3
Neuroticism (Nagel 2018)	2.3	5.4	8.5	2.9	-2.0	-2.6	-2.1	-1.7	-1.8	-2.9
Schizophrenia (2018)	1.1	2.3	5.6	1.3	-2.0	-1.3	-1.1	-2.4	-0.5	-1.4
Schizophrenia vs Biploar Disorder	0.5	0.6	2.0	1.1	-0.1	-0.7	-0.4	-1.4	-0.0	-0.5
Worry (Nagel 2018)	2.6	5.5	7.9	2.2	-1.9	-2.7	-2.2	-1.9	-2.5	-2.8
Alzheimer’s Disease (in mother)	0.5	0.6	1.8	1.4	1.0	0.6	0.5	0.4	0.9	-0.0
Alzheimer’s Disease (in father)	0.2	0.3	1.3	0.4	0.3	-0.4	-1.2	0.1	-0.2	0.1
Alzheimer’s Disease (including proxy)	0.2	0.3	1.2	1.1	0.4	-0.6	-0.5	0.4	-0.3	-0.3
Crohns Disease (2017)	0.7	1.6	4.6	1.1	-2.1	-1.2	-1.1	-1.1	-0.9	-0.8
Irritable Bowel Disease (IBD)	0.9	2.2	4.2	2.1	-2.0	-1.4	-1.4	-0.9	-1.1	-1.0
Ulcerative Colitis (UC)	1.2	2.2	7.7	2.8	-1.2	-1.3	-1.3	-0.9	-0.6	-1.4
Major Depression (MDD)	7.4	9.0	15.5	2.8	-2.5	-3.4	-1.1	-3.9	-2.5	-3.8
Reaction Time	2.0	3.9	7.8	-2.8	1.5	2.3	1.0	2.1	0.9	2.4
Verbal and Numeric Reasoning (VNR)	0.6	1.5	4.2	2.0	-0.5	-1.1	-0.1	-1.7	-0.3	-1.3
Breast Cancer	0.6	1.4	3.8	-0.9	1.9	0.7	1.4	1.5	-0.5	0.7
Ovarian Cancer	1.5	2.0	6.4	2.5	0.4	-1.0	-2.1	-0.9	-0.6	-1.1
Prostate Cancer	4.9	6.9	9.6	2.9	-2.5	-2.2	-3.1	-3.1	-0.1	-3.0
Age at First Birth	2.4	3.5	7.5	0.6	-1.8	-2.4	-2.2	-1.5	-2.7	-0.8
Bipolar Disorder (2011)	0.2	0.2	0.5	-0.5	-0.7	0.1	-0.7	-0.4	0.3	0.0
Body Mass Index (BMI) (2010)	1.5	2.1	4.0	-0.5	2.0	1.5	1.4	1.6	1.3	1.3
Coronary Artery Disease (CAD)	0.5	0.6	1.2	-0.7	-1.1	-0.7	0.1	-0.4	-1.0	-0.7
Crohns Disease (2012)	0.2	0.3	1.4	-0.0	-1.2	-0.1	-0.7	-0.5	-0.1	0.4
Mean Putamen Volume	0.7	0.8	3.2	0.3	0.3	-0.6	0.7	-1.0	0.1	-1.8
Fasting Glucose	0.2	0.2	0.6	-0.4	-0.1	-0.6	0.8	-0.2	-0.6	-0.3
HbA1C	1.0	1.1	4.8	-2.2	-0.2	0.6	0.8	1.1	0.6	0.4
HDL Cholesterol	0.9	1.5	4.5	0.2	-1.6	-0.7	-2.1	-1.4	-0.3	-0.8
LDL Cholesterol	1.6	2.6	7.0	-0.9	1.3	1.6	2.6	1.4	1.6	1.2
Lupus	0.8	1.2	2.6	1.0	-0.2	-1.6	-1.0	-0.6	-1.3	-1.3
Neuroticism (2016)	0.5	0.7	2.1	1.5	-0.5	-0.5	-1.2	-0.3	-0.8	-0.5
Primary Biliary Cirrhosis	0.1	0.1	0.4	-0.6	0.3	-0.1	0.3	0.3	-0.5	0.2
Rheumatoid Arthritis	0.9	1.2	2.7	-1.6	0.4	0.9	1.2	1.1	0.3	1.3
Schizophrenia (2014)	1.0	2.2	3.9	0.8	-1.9	-1.6	-1.5	-2.0	-1.4	-1.0
Triglycerides	0.3	0.5	1.8	-0.9	0.2	0.2	1.3	-0.1	-0.2	0.8
Type 2 Diabetes (T2D) (2012)	0.4	0.5	2.1	1.4	-0.2	-0.3	0.3	-0.2	-0.4	-0.9
Ulcerative Colitis	0.1	0.1	0.3	0.3	-0.0	-0.3	-0.3	0.6	-0.4	-0.3
Blood Eosinophil Count	0.8	6.4	12.2	2.5	-1.2	-2.9	-1.8	-3.5	-1.6	-3.2
Blood Platelet Count	0.9	9.9	21.5	2.3	-3.9	-2.5	-3.4	-4.6	-0.8	-3.0
Blood Red Count	5.8	55.7	112.0	-6.4	6.7	7.1	10.6	9.2	3.8	6.4
Blood White Count	0.0	0.4	0.9	-0.7	-0.3	0.8	0.5	0.2	0.4	1.0
Heel T-Score	4.4	35.2	59.3	5.5	-5.6	-6.7	-3.9	-7.7	-4.8	-6.5
BMI	0.1	0.5	0.8	-0.9	0.9	0.2	0.7	0.9	0.3	0.6
Height	1.1	20.7	53.9	-2.8	3.7	4.7	0.9	7.3	1.7	6.6
Waist Hip Ratio (WHR)	2.8	12.4	23.6	-3.2	4.9	3.1	4.2	3.5	2.0	3.1
Systolic Blood Pressure	0.5	2.4	7.1	-0.5	-2.7	-1.2	-1.5	-0.1	-2.4	0.3
Smoking Status	0.1	0.2	0.3	0.4	0.6	-0.0	-0.4	-0.5	0.0	-0.4
Allergy or Eczema	0.2	0.6	1.0	1.0	0.4	-0.2	-1.0	-0.7	1.0	-0.8
Cardiovascular Disease	0.2	0.7	1.8	-1.2	0.1	0.3	-0.0	1.3	-1.0	0.9
Hypothyroidism (self reported)	1.0	2.4	4.1	-1.4	1.3	1.7	0.8	2.0	1.2	1.9
Respiratory disease	1.3	2.9	7.8	2.8	-1.1	-1.6	-1.3	-1.9	-0.8	-1.6
Type 2 Diabetes (T2D) (2018)	3.1	5.9	8.8	-1.8	1.9	3.0	2.1	2.8	2.4	2.6
Lung FEV1/FVC ratio	0.3	1.3	4.9	0.2	2.2	0.3	1.8	-0.1	0.8	-0.3
Lung FVC	0.0	0.1	0.2	-0.3	0.1	0.4	-0.0	0.2	0.2	0.5
Neuroticism	2.0	4.9	10.3	2.6	-1.6	-2.4	-1.8	-1.8	-1.4	-3.2
Chronotype (morning person)	3.0	7.0	15.5	-3.9	1.3	2.2	0.8	3.8	1.1	3.2
Hair Pigment	0.2	6.2	18.5	0.8	-4.3	-1.9	-2.4	-3.2	-1.7	-1.5
Tanning	0.1	0.6	2.8	-0.2	0.5	0.6	1.7	0.9	-0.4	0.4
Hand grip strength (left)	0.1	0.3	1.0	-0.3	0.1	-0.1	0.7	1.0	-0.6	0.3
Number of treatments/medications taken	0.9	1.6	4.2	1.3	-0.4	-1.5	-0.3	-0.6	-2.1	-1.5
Average weekly spirits intake	0.7	0.9	1.5	-0.6	0.7	1.2	-0.5	1.2	1.1	1.0
Sensitivity / hurt feelings	0.1	0.2	0.4	0.6	0.1	0.0	-0.6	0.5	0.2	-0.3
Frequency of depressed mood in last 2 weeks	6.1	8.6	12.1	3.1	-2.8	-3.0	-3.5	-3.1	-1.9	-2.8
Hearing difficulty/problems: Yes	1.9	2.9	6.9	-1.0	2.6	1.7	-0.0	2.0	2.1	1.0
Relative age of first facial hair	0.6	1.3	3.4	1.1	-0.6	-0.7	1.9	-1.1	-0.7	-1.3
Other serious medical condition/disability diagnosed by doctor	1.0	1.2	2.6	-1.5	1.4	0.6	1.1	1.6	0.3	0.3
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.9	-0.1	1.4	0.3	0.4	0.0	0.7	-0.2
Ever had hysterectomy (womb removed)	0.3	0.3	0.5	0.7	-0.6	0.1	0.6	0.0	0.7	-0.6
Systolic blood pressure, automated reading	0.3	0.8	1.5	-1.1	-1.1	-0.4	-1.2	0.7	-1.0	0.4
Eye problems/disorders: Diabetes related eye disease	1.7	1.8	3.5	-1.3	0.3	1.6	1.3	1.7	0.8	1.9
Angina	0.4	0.5	0.7	0.8	0.6	-0.7	-0.6	-0.8	-0.2	-0.8
Medication for hormone replacement therapy	0.7	0.8	2.0	1.0	0.7	-0.2	-0.4	-0.6	1.1	-1.4
Vitamin and mineral supplements	0.8	1.0	3.5	-1.9	-1.2	0.5	0.7	0.7	-0.6	0.9
Supplements: Zinc	1.1	1.2	2.4	1.5	-0.4	-0.8	-1.5	-1.0	-0.1	-1.4
Medication: Co-codamol	0.3	0.4	2.0	0.4	0.1	0.1	-1.4	0.0	-0.1	0.7
Medication: Metformin	2.3	3.3	5.5	-0.2	1.7	2.3	1.4	2.3	1.7	2.1
Diabetes (father)	5.0	6.2	11.5	-2.4	3.4	2.4	1.5	2.8	0.9	3.1
Diabetes (mother)	0.3	0.4	1.1	0.1	-0.2	-0.7	0.5	0.1	-1.0	-0.8
Severe depression (siblings)	3.5	3.9	6.0	1.0	-1.5	-2.5	-1.9	-1.9	-2.2	-2.4
Pack years adult smoking proportion	0.1	0.2	0.8	0.3	-0.1	0.6	0.9	-0.1	0.3	-0.1
Impedance of leg (right)	0.1	0.7	1.5	1.2	-0.8	-0.6	-0.6	-1.2	-0.2	-0.9
Leg fat-free mass (left)	1.1	6.0	16.4	-1.9	1.9	2.4	0.9	4.0	0.6	3.4
Trunk fat percentage	0.4	1.6	3.1	-1.5	1.6	0.9	-0.3	1.8	0.4	1.5
Hand grip strength (right)	0.4	1.0	2.8	-0.8	1.0	0.9	1.0	1.7	-0.0	1.0
Townsend deprivation index at recruitment	0.6	0.9	3.1	0.0	1.8	0.5	1.5	0.2	0.7	-0.0
Current tobacco smoking	0.1	0.2	0.5	0.3	0.7	0.5	0.4	0.4	0.2	0.2
Average weekly fortified wine intake	0.3	0.4	1.6	-1.3	-0.3	-0.2	-0.4	0.0	-0.9	0.0
Maternal smoking around birth	2.7	4.0	7.2	0.6	2.5	2.1	2.7	1.4	2.6	0.7
Fed-up feelings	1.5	2.7	8.2	2.9	-1.6	-1.3	-2.0	-0.6	-0.3	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	5.0	6.6	9.6	3.1	-2.6	-2.7	-2.8	-2.3	-1.7	-2.5
Relative age voice broke	0.1	0.2	0.4	0.3	-0.6	-0.1	-0.4	-0.2	-0.6	0.5
Taking other prescription medications	1.0	1.5	2.9	1.2	-0.2	-1.7	0.0	-1.1	-1.7	-1.4
Age when periods started (menarche)	1.6	3.8	7.4	2.7	-1.9	-2.0	-1.1	-2.0	-1.0	-2.4
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	3.3	1.1	-1.3	-1.2	-0.3	-0.8	-0.8	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.6	6.2	2.4	-2.4	-1.3	-1.3	-2.5	-0.2	-2.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.1	1.0	0.4	0.5	0.5	-0.2	1.0	0.0
Qualifications: CSEs or equivalent	0.6	0.7	3.8	2.0	0.1	0.4	-0.5	0.5	0.8	-0.2
Serious illness, injury or assault to yourself	0.4	0.5	1.7	0.8	-0.1	0.3	-0.0	-0.7	1.3	-0.6
High blood pressure	0.6	1.8	6.7	-1.8	-1.0	-1.0	-0.2	0.6	-2.6	0.1
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.6	1.3	0.3	-0.2	-1.2	-0.5	0.8	-0.8
Multivitamins +/- minerals	0.5	0.6	1.5	1.2	1.0	-0.1	-0.7	-0.5	0.7	-0.5
Stomach or abdominal pain in last month	0.2	0.2	0.9	0.1	0.1	0.4	0.3	0.9	0.2	0.6
Supplements: Glucosamine	0.1	0.2	0.3	0.3	0.3	0.1	0.3	0.5	0.4	-0.6
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.0	0.7	1.4	0.3	0.4	-0.2	0.8	-0.7
Medication: Atenolol	0.5	0.6	1.9	-1.3	-0.4	-0.2	0.2	0.6	-1.4	0.5
Medication: Levothyroxine sodium	0.5	0.9	2.2	-1.0	1.5	0.6	-0.3	1.2	0.4	1.1
Sitting height	1.2	8.3	16.9	-1.6	1.9	3.6	0.5	4.1	2.2	4.1
Chronic bronchitis/emphysema (father)	0.4	0.4	1.4	0.5	-0.5	-0.4	0.4	-0.9	0.3	-1.2
High blood pressure (mother)	0.6	0.8	2.3	0.8	-1.2	-0.5	-1.5	0.5	-0.5	-0.7
Body mass index (BMI)	0.2	0.7	2.0	-1.0	1.2	0.3	0.5	1.4	0.1	0.4
Impedance of leg (left)	0.1	0.4	1.2	0.7	-0.1	-0.3	-0.5	-1.1	0.2	-0.8
Leg predicted mass (left)	1.1	6.0	16.3	-1.8	2.0	2.4	0.9	4.0	0.7	3.4
Trunk fat mass	0.7	2.9	6.9	-1.7	2.0	1.3	0.2	2.6	0.4	2.1
Waist circumference	1.1	4.2	8.1	-2.1	2.8	1.5	1.7	2.9	0.4	1.9
Number of incorrect matches in round	0.6	1.1	4.1	0.2	-0.5	-1.0	-2.0	0.1	-1.1	-0.9
Past tobacco smoking	0.3	0.6	1.0	-0.7	-0.7	0.1	1.0	1.0	-0.7	1.0
Alcohol usually taken with meals	0.2	0.4	0.7	0.6	0.2	-0.4	-0.8	-0.5	-0.9	0.4
Nervous feelings	3.6	6.7	10.2	2.8	-3.2	-2.6	-2.8	-2.0	-2.0	-2.5
Frequency of tenseness / restlessness in last 2 weeks	3.8	6.0	12.1	3.5	-1.9	-2.6	-2.1	-2.5	-1.5	-2.5
Hearing difficulty/problems with background noise	0.4	0.7	1.5	0.9	1.2	-0.6	-0.4	-1.2	0.1	-0.6
Hair/balding pattern: Pattern 2	0.6	0.7	2.4	-1.1	-0.4	0.8	0.1	1.5	0.4	0.8
Had menopause	2.9	3.6	5.6	-1.6	2.4	2.0	0.4	2.0	1.8	2.4
Had other major operations	0.5	0.7	1.7	-0.8	0.5	1.0	1.3	0.9	0.2	0.3
Forced vital capacity (FVC)	1.0	3.7	6.2	-1.2	1.6	2.5	0.5	2.3	2.2	2.4
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.2	10.3	2.2	-3.2	-2.0	-1.8	-3.0	-1.3	-1.7
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	3.5	1.3	-1.9	-1.2	-1.7	-1.3	-0.4	-1.8
Qualifications: None of the above	4.0	8.5	16.3	-2.5	3.6	2.8	1.9	4.0	2.1	3.0
Financial difficulties in last 2 years	0.7	1.0	2.0	1.4	-0.1	-1.0	-0.3	-0.2	-1.3	-1.3
Mouth/teeth dental problems	0.3	0.5	1.0	-0.8	-0.6	0.2	-0.7	0.8	-0.8	1.0
Heart attack	0.3	0.4	1.1	-1.1	-0.6	-0.6	-0.4	-0.4	-0.9	-0.1
Allergy	0.6	1.4	4.5	-2.1	-0.3	0.8	0.9	1.3	-0.3	1.5
Pain all over the body in last month	1.9	2.1	5.7	-1.0	1.3	1.6	0.6	1.5	1.0	2.4
Diabetes (self-reported)	1.9	2.9	4.1	-0.3	1.4	2.0	2.0	2.0	2.0	1.6
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	4.3	2.1	-0.6	-1.1	-1.4	-2.0	0.1	-1.1
Medication: Ramipril	0.8	1.0	3.3	-0.4	0.7	0.3	-0.3	1.8	-0.7	1.5
Medication: Simvastatin	0.7	1.0	1.8	1.2	-1.1	-0.6	-1.2	-1.4	-0.2	-0.9
Fluid intelligence score	1.0	2.1	4.5	2.1	-2.1	-1.2	-0.2	-1.7	-0.5	-1.1
Illnesses of siblings	1.0	1.4	3.0	1.4	-1.1	-1.3	-0.1	-1.7	-0.5	-1.3
Neuroticism score	3.4	7.0	11.6	3.4	-2.4	-2.9	-3.0	-1.8	-2.0	-2.7
Weight	1.1	5.5	13.8	-1.9	2.6	2.1	0.9	3.7	0.8	2.9
Impedance of arm (right)	0.2	1.0	3.4	0.3	-1.9	-0.4	-1.5	-0.6	-0.5	0.2
Arm fat percentage (right)	0.3	1.0	2.7	-1.5	0.6	0.5	-0.3	1.6	-0.0	1.2
Trunk fat-free mass	1.0	5.6	14.3	-1.4	2.3	2.4	1.3	3.8	0.7	3.0
Hip circumference	0.3	1.4	5.0	-1.2	0.6	0.8	-0.4	2.2	-0.0	1.3
Time employed in main current job	2.5	2.8	5.3	0.4	-2.3	-1.8	-1.3	-1.3	-2.3	-1.6
Alcohol intake versus 10 years previously	1.3	2.0	3.4	-1.0	1.8	1.8	0.6	1.0	1.8	1.2
Father’s age at death	0.4	0.5	0.6	0.8	-0.7	-0.5	-0.6	-0.8	-0.7	-0.8
Worrier / anxious feelings	3.5	6.6	10.2	3.1	-1.8	-3.2	-2.3	-2.1	-2.0	-3.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.5	1.1	-1.2	-0.8	-1.2	-0.7	-0.3	-0.8
Falls in the last year	0.2	0.3	0.9	-0.5	-0.5	-0.5	-0.8	-0.1	-0.9	0.1
Hair/balding pattern: Pattern 3	0.4	0.6	1.5	-0.5	1.1	0.7	-0.1	-0.3	0.8	1.2
Number of live births	2.3	3.3	5.8	-2.0	1.4	1.8	2.4	1.9	0.8	1.9
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	3.8	-0.9	1.6	2.0	0.5	1.7	1.9	1.7
Pulse rate	1.2	2.0	4.6	0.1	-1.9	-1.8	-0.4	-0.3	-2.1	-1.5
Happiness	3.6	4.4	10.1	1.7	-3.2	-1.7	-2.0	-2.3	-0.8	-2.2
Noisy workplace	0.2	0.2	0.8	0.9	-0.2	-0.4	0.2	0.0	-0.1	-0.6
Qualifications: A levels/AS levels or equivalent	2.5	5.5	9.4	1.9	-2.7	-2.6	-1.1	-3.1	-1.9	-2.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.4	-0.4	1.0	0.8	0.8	-0.1	1.2	0.3
Mouth/teeth dental problems: Dentures	1.0	1.7	4.3	0.7	2.1	1.3	1.1	0.3	2.0	0.5
Asthma	1.6	3.1	7.8	2.8	-0.5	-1.9	-0.9	-2.2	-1.0	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.8	1.0	-0.3	-0.8	-0.0	-0.4	-1.3	-0.6
Medication: Cholesterol lowering	0.4	0.7	1.7	1.3	-0.3	-0.8	-0.4	-0.6	-0.4	-1.3
Depression (self-reported)	3.6	4.3	6.4	1.7	-2.3	-2.2	-2.5	-2.1	-2.1	-1.5
Medication: Lansoprazole	1.1	1.2	1.8	0.9	-0.7	-1.3	-0.3	-1.3	-1.3	-1.3
Prospective memory result	0.4	0.5	1.6	0.3	0.6	-0.9	0.1	0.0	-1.2	-0.7
Lung cancer (father)	0.3	0.4	1.0	-1.0	-0.7	0.3	0.6	0.4	-0.2	0.9
Illnesses of mother	0.5	0.7	3.2	-1.8	-0.5	0.2	0.7	0.0	-0.1	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.6	-0.4	1.2	1.9	0.9	1.6	1.6	1.5
Pulse wave Arterial Stiffness index	0.4	0.5	1.4	-0.7	1.2	0.2	1.1	0.4	-0.3	0.4
Impedance of arm (left)	0.1	0.6	1.7	-0.3	-1.3	-0.1	-1.2	-0.6	-0.3	0.5
Arm fat mass (right)	0.7	3.1	7.5	-1.9	1.9	1.5	0.6	2.7	0.6	2.0
Trunk predicted mass	1.0	5.5	14.1	-1.3	2.3	2.4	1.2	3.8	0.8	3.0
Standing height	1.5	14.6	32.5	-2.3	3.5	4.2	0.9	5.7	1.6	5.6
Length of working week for main job	0.5	0.5	2.3	-0.1	-1.1	-0.4	-1.5	0.1	-0.4	0.2
Exposure to tobacco smoke at home	0.1	0.2	0.5	-0.7	0.3	0.1	0.2	-0.2	0.4	-0.4
Breastfed as a baby	1.2	1.5	4.1	0.6	-1.1	-1.2	1.2	-1.2	-0.6	-2.0
Tense / ‘highly strung’	0.9	1.4	2.5	1.4	-1.5	-1.0	-1.6	-1.1	-0.9	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	5.6	1.9	-0.8	-2.0	-2.4	-1.9	-1.2	-1.7
Hair/balding pattern: Pattern 4	0.3	0.7	2.4	-1.0	0.0	0.1	0.1	1.6	-0.8	0.8
Birth weight of first child	0.1	0.2	0.8	-0.4	0.0	0.5	-0.9	0.2	0.1	0.4
Peak expiratory flow (PEF)	0.2	0.4	1.8	0.4	0.5	0.7	0.2	0.1	1.3	-0.2
Pulse wave reflection index	1.1	1.4	4.9	0.1	2.2	0.8	1.6	0.6	1.0	0.6
Ever highly irritable/argumentative for 2 days	0.6	0.7	3.6	1.9	-0.6	-0.2	-0.6	0.1	0.5	-0.6
Loud music exposure frequency	1.6	1.8	4.8	2.2	-0.6	-0.7	-0.2	-1.6	0.5	-2.0
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.0	0.7	-1.2	-0.6	1.0	-1.4	-0.1	-1.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.5	-0.6	-0.9	-1.1	0.5	-0.5	-1.2	-1.0
Blood clot in the leg (DVT)	0.7	1.0	2.1	-0.4	1.1	1.1	1.4	-0.5	1.3	0.3
Medication: Paracetamol	2.5	4.2	7.6	1.9	-1.8	-2.2	-1.4	-2.5	-1.6	-2.8
Headache pain in last month	2.1	3.6	7.6	1.2	-2.8	-1.9	-0.5	-1.6	-1.9	-2.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	-0.2	-0.7	-0.5	-0.3	-0.9	0.2	-0.5
Glaucoma (self-reported)	0.2	0.2	0.9	0.1	-1.0	0.0	0.5	-0.2	0.4	-0.2
Gout (self-reported)	0.8	1.0	2.4	-1.2	1.6	0.5	1.0	1.0	-0.3	1.1
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	3.1	-1.0	1.3	1.3	0.5	1.7	1.1	1.7
Medication: Amlodipine	0.7	1.0	3.8	0.6	-1.6	-0.5	-1.9	-0.5	-0.2	0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	0.4	0.8	0.3	-0.9	-0.1	0.7	0.4
Birth weight	3.0	6.5	10.1	1.7	-3.2	-2.9	-2.1	-2.3	-2.9	-2.5
Chronic bronchitis/emphysema (mother)	1.6	1.9	7.5	0.6	1.6	0.9	2.7	-0.3	1.3	-0.1
High blood pressure (siblings)	0.4	0.6	1.7	-0.8	0.5	0.8	0.6	1.3	-0.1	0.6
Forced vital capacity (FVC), Best measure	0.6	2.3	4.3	-0.6	0.9	2.1	0.7	2.0	1.6	1.9
Body fat percentage	0.5	1.9	4.0	-1.8	1.7	0.9	0.1	2.0	0.3	1.6
Leg fat percentage (right)	0.2	0.9	2.8	-1.2	1.0	0.2	0.1	1.7	-0.2	0.8
Arm fat-free mass (right)	1.6	8.0	15.9	-2.0	3.4	2.8	1.7	4.0	1.3	3.4
Exposure to tobacco smoke outside home	0.6	0.8	4.6	0.1	0.8	0.2	2.1	0.1	0.3	-0.6
Comparative body size at age 10	0.2	0.5	1.5	0.4	0.7	0.5	1.0	0.1	1.2	-0.5
Number of full brothers	0.7	0.9	2.2	-0.5	0.7	1.3	1.4	-0.1	1.5	0.3
Worry too long after embarrassment	2.1	3.6	5.3	2.3	-1.8	-1.9	-1.3	-2.3	-1.1	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	1.0	-0.3	-0.9	-0.5	-0.5	-0.6	-0.8
Wheeze or whistling in the chest in last year	0.8	1.5	3.2	0.5	-0.5	-1.5	-1.3	-1.8	-1.3	-1.1
Number of children fathered	2.5	2.8	5.5	-2.1	1.6	1.4	1.6	2.3	0.5	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.4	-0.2	-0.5	-1.1	1.2	-1.6	-1.1	-1.1
Age at first live birth	7.0	12.5	17.3	4.2	-3.1	-3.9	-3.5	-3.7	-2.7	-3.5
Pulse wave peak to peak time	0.3	0.3	1.0	0.4	-1.0	0.2	-1.0	0.1	0.4	0.1
Health satisfaction	0.2	0.2	0.7	-0.4	0.2	0.2	0.5	0.8	-0.3	0.4
Shortness of breath walking on level ground	0.1	0.2	0.5	0.1	-0.7	-0.1	-0.4	0.3	-0.6	0.4
Qualifications: College or University degree	3.9	12.3	18.9	3.1	-4.0	-3.9	-2.4	-4.3	-2.9	-3.6
Eye problems/disorders: None of the above	3.0	3.5	5.6	0.7	-1.1	-2.3	-2.2	-1.9	-2.4	-1.8
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.8	-0.9	-0.3	-0.2	-0.6	0.6	-0.9	0.2
Emphysema/chronic bronchitis	0.5	0.5	1.1	0.9	1.1	-0.2	0.1	-0.9	0.6	-0.6
Medication for pain relief, constipation, heartburn	1.1	1.9	2.8	-1.4	0.4	1.3	1.6	1.6	1.2	1.7
Neck or shoulder pain in last month	0.2	0.3	1.0	-0.7	1.0	0.3	-0.4	-0.1	-0.1	0.7
Medication: Blood pressure	0.2	0.4	1.4	-0.3	1.2	0.3	0.3	0.3	-0.7	0.7
Angina (self-reported)	0.4	0.5	0.9	0.9	0.6	-0.7	-0.8	-0.8	-0.2	-0.8
Migraine (self-reported)	0.7	0.9	2.2	0.5	-0.4	-0.6	-1.0	-1.5	0.7	-1.4
Medication: Ibuprofen	1.2	1.4	3.6	1.4	-0.8	-1.3	-0.5	-0.8	-1.9	-1.1
Medication: Allopurinol	1.7	2.3	4.2	-1.7	2.0	0.9	1.8	1.7	-0.4	1.4
Medication: Omeprazole	0.2	0.3	0.8	0.1	-0.1	-0.7	0.0	-0.7	-0.9	-0.4
Medication: Seretide 50 evohaler	0.9	1.1	3.1	0.9	1.8	0.9	-0.1	0.9	1.2	0.7
Mean time to correctly identify matches	1.6	3.1	8.9	-3.0	1.5	1.7	0.5	1.9	0.6	1.8
Heart disease (mother)	2.2	2.7	6.3	-1.2	1.9	1.7	0.3	1.9	0.9	2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.2	5.2	2.3	-1.2	-1.4	-1.1	-1.6	-0.5	-1.6
Whole body fat mass	0.9	3.7	8.6	-2.0	2.2	1.5	0.5	2.9	0.5	2.3
Leg fat mass (right)	0.8	3.0	8.0	-2.0	1.9	1.1	0.8	2.8	0.1	1.9
Arm predicted mass (right)	1.5	7.9	17.0	-2.1	3.3	2.7	1.6	4.1	1.1	3.4
Pulse rate, automated reading	1.6	5.2	7.7	0.8	-2.8	-2.5	-2.0	-2.2	-2.5	-2.6
Alcohol intake frequency.	1.2	2.8	4.1	-2.0	1.7	1.8	0.3	2.0	1.2	2.0
Comparative height size at age 10	0.7	4.0	11.2	-1.6	1.0	1.7	-1.2	3.0	-0.2	3.4
Number of full sisters	2.1	2.6	4.8	-1.0	1.6	1.6	-0.8	2.2	1.4	2.0
Suffer from ‘nerves’	1.7	2.6	5.2	1.6	-1.5	-1.5	-2.3	-1.4	-2.0	-0.8
Overall health rating	0.2	0.3	0.8	0.9	0.1	-0.3	-0.9	0.4	-0.1	-0.7
Chest pain or discomfort	1.1	1.6	3.5	1.7	-0.6	-1.3	-0.9	-1.9	-0.6	-1.1
Had major operations	1.1	1.3	2.6	1.6	-0.4	-1.4	0.5	-0.4	-1.2	-1.6
Age at last live birth	1.6	2.3	3.0	1.7	-1.4	-1.6	-1.3	-1.4	-1.3	-1.7
Family relationship satisfaction	2.7	3.3	7.2	1.6	-2.7	-1.8	-1.3	-2.1	-1.1	-1.7
Leg pain on walking	0.7	0.9	2.9	-0.3	1.2	0.8	1.7	1.1	0.1	0.5
Qualifications: NVQ or HND or HNC or equivalent	2.4	2.9	6.6	-1.4	1.1	2.4	1.3	0.9	2.6	1.4
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.8	1.0	-1.4	-0.5	-0.2	-1.2	-0.2	-0.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.8	0.5	-0.7	-0.9	-0.4	-0.3	-0.7	-0.9
Medication: Aspirin	0.2	0.3	0.7	0.7	0.0	-0.3	-0.9	-0.1	-0.1	-0.8
Supplements: Vitamin C	0.8	1.0	2.3	1.5	0.1	-1.2	-0.6	-0.6	-0.6	-1.4
Knee pain experienced in last month	0.7	1.0	2.0	-0.7	1.4	0.8	1.1	1.4	0.2	1.0
Hypertension (Self-reported)	0.5	1.3	5.4	-1.5	-0.6	-0.8	-0.4	0.6	-2.3	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	1.7	1.3	-1.0	-1.3	-0.9	-0.9	-1.3	-0.7
Illnesses of father: Heart disease	0.5	0.6	2.6	-1.6	0.0	0.3	0.9	0.1	0.9	-0.1
Illnesses of siblings: Diabetes	4.5	5.5	7.2	-2.3	2.3	2.6	1.6	2.7	2.2	2.6
Smoking status: Previous	0.4	0.5	1.3	0.3	1.0	0.4	-0.6	-0.7	1.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	4.0	-0.1	0.2	1.2	-1.4	2.0	0.7	1.8
Whole body fat-free mass	1.2	6.6	17.2	-1.8	2.4	2.6	1.2	4.2	0.8	3.4
Leg fat-free mass (right)	1.4	7.4	18.1	-2.3	2.3	2.7	1.1	4.3	1.0	3.7
Arm fat percentage (left)	0.3	1.0	2.6	-1.6	0.8	0.5	-0.2	1.5	0.0	1.2
Average weekly red wine intake	1.1	1.6	4.9	1.0	-1.0	-1.1	0.0	-2.2	-1.3	-1.1
Handedness (chirality/laterality): Left-handed	1.7	2.1	4.2	1.1	-1.5	-1.5	-0.6	-2.0	-0.5	-2.1
Mood swings	1.1	1.9	3.9	2.0	-1.5	-1.3	-1.5	-0.6	-0.4	-1.7
Loneliness, isolation	0.3	0.4	1.0	0.6	-0.4	-0.8	-1.0	-0.4	-0.2	-0.8
Long-standing illness, disability or infirmity	0.5	0.8	1.8	-1.3	1.0	0.3	0.1	1.1	-0.6	1.0
Ever had bowel cancer screening	1.0	1.2	3.7	-1.2	1.9	0.5	0.8	1.3	0.2	0.8
Diabetes diagnosed by doctor	1.1	1.9	2.7	-0.5	1.1	1.6	1.6	1.6	1.2	1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.3	-0.9	0.5	0.5	0.5	0.5	-0.1	1.1
Friendships satisfaction	1.1	1.4	2.7	0.8	-1.7	-1.1	-0.7	-1.1	-1.1	-1.4
Qualifications: nursing, teaching	2.1	3.2	8.8	3.0	-1.6	-1.6	-0.9	-1.6	-1.1	-1.9
Commuting to job workplace: Walk	1.0	1.1	5.9	-0.0	-0.7	-0.6	-2.4	-0.5	-0.6	-0.1
Eye problems/disorders: Cataract	2.1	2.4	5.1	-1.5	0.8	1.9	1.1	1.9	1.1	2.2
Mouth/teeth dental problems: Mouth ulcers	2.8	4.5	7.5	2.1	-2.7	-1.9	-1.8	-2.4	-0.7	-2.4
Medication for cholesterol	0.1	0.2	0.4	0.0	0.2	0.5	0.5	-0.6	0.7	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.5	0.9	-1.2	-0.3	-0.1	-1.0	0.4	-0.8
Back pain experienced in last month	1.1	1.7	3.6	-1.2	0.4	1.6	-0.9	1.2	1.3	1.9
Mineral and other dietary supplements	0.1	0.1	0.6	0.1	-0.3	0.3	0.1	-0.8	0.3	0.2
Breast cancer (self-reported)	2.1	2.5	4.1	1.9	-0.7	-1.9	-2.0	-0.7	-1.9	-1.3
Asthma (self-reported)	1.7	3.4	8.1	2.8	-0.7	-2.0	-1.2	-2.2	-0.9	-2.0
Osteoporosis (self-reported)	0.5	0.6	2.5	-1.0	0.2	0.6	1.6	0.4	0.3	0.5
Osteoarthritis (self-reported)	0.2	0.2	0.6	0.3	-0.4	-0.4	0.6	-0.8	-0.5	0.1
Medication: Aspirin	0.3	0.4	0.6	-0.1	0.7	0.7	-0.8	0.7	0.7	0.3
Medication: Gliclazide	2.8	3.2	6.3	-0.6	2.2	1.8	1.7	2.5	1.2	1.8
Illnesses of father: None of the above (group 1)	0.7	0.9	1.6	1.3	-0.8	-0.7	-0.8	-1.2	-0.8	-0.7
Smoking status: Current	0.1	0.2	0.6	0.2	0.8	0.4	0.4	0.4	0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	1.4	-0.6	1.2	0.4	0.1	0.4	0.4	0.0
Whole body water mass	1.1	6.5	17.0	-1.7	2.4	2.5	1.2	4.1	0.8	3.3
Leg predicted mass (right)	1.4	7.3	18.1	-2.3	2.4	2.7	1.1	4.2	1.0	3.6
Arm fat mass (left)	0.6	2.3	5.6	-1.7	1.7	1.2	0.5	2.4	0.4	1.8
Number of self-reported non-cancer illnesses	1.9	3.3	7.0	2.6	-0.5	-2.1	-1.1	-1.9	-1.3	-2.2
Average weekly champagne plus white wine intake	2.1	2.9	5.6	1.7	-1.0	-2.4	-1.0	-1.1	-2.1	-2.0
Miserableness	1.8	3.1	6.3	2.5	-1.7	-1.4	-1.1	-2.0	-0.0	-2.3
Guilty feelings	1.2	1.9	5.3	2.3	-0.8	-1.4	-1.3	-0.9	-0.6	-1.5
Wears glasses or contact lenses	1.5	1.8	2.7	1.3	-1.6	-1.6	-1.0	-1.0	-1.4	-1.2
Ever taken oral contraceptive pill	0.9	1.0	3.4	-1.5	0.3	0.1	1.8	-0.9	-0.2	-0.4
Hearing aid user	2.5	2.9	5.8	-0.8	1.4	2.1	1.0	2.4	2.2	1.2
Mother’s age at death	0.6	0.7	1.2	0.4	-1.0	-1.0	0.4	-1.1	-0.6	-1.0
Financial situation satisfaction	1.0	1.3	3.8	2.0	-1.2	-0.9	-0.3	-0.7	-0.5	-1.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.8	-1.7	0.7	0.5	-0.5	0.3	-0.0	0.4
Commuting to job workplace: Public transport	0.3	0.4	1.3	0.6	0.0	-0.4	0.2	-0.8	-0.0	-1.1
Eye problems/disorders: Glaucoma	0.3	0.3	1.2	0.4	-0.5	0.1	1.1	-0.3	0.8	-0.3
Medication: Blood pressure	0.7	1.3	4.8	-1.4	-0.9	-1.1	0.0	0.2	-2.2	0.0
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.9	-1.0	1.0	1.4	-0.7	0.3	0.9	0.7
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.6	-0.5	1.2	-0.1	0.0	1.3	-0.5	0.3
High cholesterol (Self-reported)	0.0	0.1	0.3	0.4	0.1	-0.1	0.2	-0.1	-0.1	-0.6
Medication: Bendroflumethiazide	0.9	1.4	5.3	-0.6	0.9	0.6	1.3	2.3	-0.8	0.9
Medication: Paracetamol	2.8	4.3	8.0	1.9	-1.9	-2.1	-1.4	-2.5	-1.5	-2.8
Medication: Lisinopril	0.3	0.4	1.1	-1.0	0.8	0.0	0.5	-0.3	-1.1	0.2
Medication: Atorvastatin	0.4	0.5	2.3	-0.4	0.7	0.3	-0.1	1.5	0.2	0.7
Illnesses of father: High blood pressure	1.1	1.3	4.1	-1.0	0.2	1.0	0.5	2.0	0.0	1.8
Alcohol drinker status: Never	0.9	1.1	4.1	0.1	2.0	0.6	0.2	1.3	1.2	0.0
Ever smoked	0.1	0.3	0.7	0.5	0.3	-0.4	-0.5	-0.6	0.0	-0.8
Basal metabolic rate	1.2	6.4	16.3	-1.9	2.5	2.5	1.1	4.0	0.7	3.3
Leg fat percentage (left)	0.3	1.1	2.8	-1.4	1.4	0.3	0.3	1.7	0.1	0.8
Arm fat-free mass (left)	1.3	6.4	15.6	-1.6	3.0	2.5	1.1	4.0	1.1	3.0
Number of operations (self-reported)	0.6	0.9	1.7	1.0	-0.9	-1.0	0.1	-0.6	-1.2	-1.3
Average weekly beer plus cider intake	0.2	0.3	0.5	-0.2	0.2	0.6	0.6	0.6	0.6	0.7
Irritability	0.5	0.8	2.8	1.1	-1.7	-0.7	-0.6	-0.1	-0.9	-0.6
Risk taking	9.1	13.3	18.6	-3.5	3.3	4.3	3.6	3.8	3.3	3.7
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.2	1.5	-0.2	-1.3	-0.2	-1.1	-1.2	-0.6
Fractured/broken bones in last 5 years	1.9	2.4	6.0	-0.6	2.4	1.3	2.4	1.2	0.9	1.2
Age started oral contraceptive pill	1.2	1.5	3.0	-0.9	1.3	1.4	0.5	1.7	1.5	0.9
Diastolic blood pressure, automated reading	0.2	0.7	2.6	-0.9	-0.3	0.2	0.2	1.6	-0.7	1.1
Ever depressed for a whole week	2.2	2.7	6.5	1.7	-0.6	-1.8	-1.6	-1.4	-1.3	-2.6
Unable to work because of sickness or disability	0.5	0.6	2.4	-0.9	-1.6	-0.2	-0.5	-0.4	-0.8	0.2
Commuting to job workplace: Cycle	0.3	0.3	0.9	1.0	-0.2	0.2	-0.7	0.6	0.5	-0.1
Myopia	3.2	4.6	5.9	2.0	-2.4	-2.3	-1.1	-2.4	-2.2	-2.4
Vascular/heart problems diagnosed by doctor	0.6	1.6	6.4	1.6	0.9	1.2	-0.0	-0.2	2.5	0.4
Cholesterol lowering medication	0.1	0.2	0.5	0.5	-0.7	-0.5	-0.1	-0.4	-0.4	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.9	-0.5	-0.8	-1.1	-0.9	-0.8	-1.4	-0.4
Pain experienced in last month	0.7	1.2	2.2	0.7	-1.0	-1.4	-0.8	-1.1	-0.9	-1.5
Supplements: Calcium	0.3	0.4	1.2	-0.2	1.1	-0.2	-0.7	0.7	-0.4	0.2
Basal cell carcinoma (self-reported)	1.2	1.5	4.2	-0.2	0.7	1.8	0.1	0.5	2.0	1.5
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.8	-0.9	-0.4	-0.3	-0.2	-0.2	-0.6	0.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.2	-0.4	1.1	1.4	1.5	-0.3	1.4	0.4
Heart disease (siblings)	0.7	0.9	1.8	-0.5	1.3	0.9	-1.1	0.2	1.1	1.0
Alcohol drinker status: Previous	0.7	0.7	2.4	0.0	-0.4	-1.1	-0.6	-1.1	-1.5	-0.0
Pack years of smoking	0.1	0.2	0.7	0.3	0.2	0.5	0.8	-0.1	0.3	-0.2
Impedance of whole body	0.0	0.2	0.8	0.1	-0.5	-0.0	-0.9	-0.6	0.1	0.1
Leg fat mass (left)	0.8	3.2	7.9	-2.1	2.0	1.2	0.8	2.8	0.3	1.9
Arm predicted mass (left)	1.5	7.8	18.0	-1.9	3.1	2.9	1.5	4.2	1.3	3.3