Hub : Genes

HSPA2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.0750 0.0320 0.0067 0.006 NA 0.019 NA 0.026 0.1100 NA 0.012 NA 0.0044
2 GTEx Lung 0.0761 0.0340 0.0064 0.032 NA 0.006 NA 0.023 0.0017 NA 0.099 NA 0.0068
3 GTEx Nerve Tibial 0.0996 0.0391 0.0011 0.011 NA 0.010 NA 0.002 0.0550 NA 0.057 NA 0.2100
4 TCGA Kidney Renal Clear Cell Carcinoma 0.0432 0.0263 0.0017 0.022 0.012 0.007 NA 0.017 0.0013 0.015 0.043 NA 0.0043

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.2 0.4 0.7 0.8 -0.9 -0.3 0.1
Bipolar Disorder or Schizophrenia 1.8 4.4 6.4 2.5 -2.2 -2.0 -1.6
Depressed Affect (Nagel 2018) 0.3 0.6 1.1 -1.1 0.6 -0.1 1.1
Depression (Nagel 2018) 1.8 2.7 3.6 1.8 -1.7 -1.9 -1.0
Intelligence (Savage-Jansen 2018) 1.0 3.0 7.0 1.5 -1.0 -1.4 -2.7
Neuroticism (Nagel 2018) 0.9 2.1 3.3 1.3 -1.8 -1.7 -0.7
Schizophrenia (2018) 2.5 5.3 6.7 2.6 -2.2 -2.3 -2.1
Schizophrenia vs Biploar Disorder 1.0 1.3 1.7 1.3 -1.1 -0.9 -1.1
Worry (Nagel 2018) 2.3 4.9 6.8 2.4 -2.6 -2.3 -1.4
Alzheimer’s Disease (in mother) 0.8 1.0 1.7 1.3 -1.0 -0.8 -0.8
Alzheimer’s Disease (in father) 2.1 2.3 3.4 1.7 -1.8 -1.3 -1.0
Alzheimer’s Disease (including proxy) 3.3 4.7 6.2 2.5 -2.3 -2.0 -1.9
Crohns Disease (2017) 3.4 7.4 8.0 2.8 -2.7 -2.7 -2.7
Irritable Bowel Disease (IBD) 2.0 4.7 5.5 2.3 -2.1 -2.2 -2.0
Ulcerative Colitis (UC) 0.9 1.6 2.2 1.5 -1.3 -1.2 -1.1
Major Depression (MDD) 1.2 1.5 2.6 1.3 -0.6 -1.6 -1.0
Reaction Time 0.1 0.2 0.7 -0.8 0.2 0.2 -0.1
Verbal and Numeric Reasoning (VNR) 0.9 2.1 7.9 0.6 -0.4 -0.3 -2.8
Breast Cancer 0.1 0.3 0.9 0.2 -0.2 0.2 -0.9
Ovarian Cancer 1.0 1.3 2.4 1.1 -1.0 -0.8 -1.5
Prostate Cancer 0.7 1.0 2.4 1.0 -0.2 -0.9 -1.6
Age at First Birth 4.2 6.1 6.8 2.3 -2.6 -2.5 -2.5
Bipolar Disorder (2011) 0.3 0.2 0.5 -0.5 0.1 0.4 0.7
Body Mass Index (BMI) (2010) 1.9 2.5 3.2 -1.6 1.8 1.6 1.3
Coronary Artery Disease (CAD) 0.6 0.7 1.5 0.7 -0.8 -1.2 -0.5
Crohns Disease (2012) 2.0 3.3 4.0 2.0 -1.9 -1.8 -1.6
Mean Putamen Volume 0.3 0.3 0.9 0.9 -0.2 -0.3 0.3
Fasting Glucose 1.1 1.3 4.2 -0.8 0.3 0.1 2.0
HbA1C 0.5 0.5 1.3 0.7 -0.5 -0.3 -1.1
HDL Cholesterol 0.5 0.8 1.2 0.8 -1.1 -1.1 -0.7
LDL Cholesterol 0.3 0.4 0.9 0.6 -0.7 -0.1 -0.9
Lupus 0.4 0.7 1.9 -0.7 1.4 0.3 0.4
Neuroticism (2016) 2.3 3.3 5.7 2.0 -2.4 -1.2 -1.5
Primary Biliary Cirrhosis 1.8 2.5 4.3 -1.8 1.5 0.7 2.1
Rheumatoid Arthritis 1.4 1.9 3.1 -1.3 1.0 1.3 1.8
Schizophrenia (2014) 4.2 9.3 11.1 3.3 -3.1 -3.0 -2.8
Triglycerides 0.1 0.2 0.6 0.3 -0.1 0.0 0.8
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.1 -0.4 0.2 -0.2 -0.2
Ulcerative Colitis 0.1 0.1 0.5 -0.1 0.1 0.1 0.7
Blood Eosinophil Count 0.6 4.6 11.2 1.7 -1.2 -1.6 -3.4
Blood Platelet Count 0.0 0.4 0.8 0.1 0.9 -0.8 -0.1
Blood Red Count 0.4 4.1 11.3 -1.0 0.9 3.4 1.8
Blood White Count 1.6 11.9 14.9 3.9 -3.7 -2.3 -3.8
Heel T-Score 4.4 35.2 42.5 6.5 -5.3 -5.8 -6.0
BMI 0.4 2.1 3.7 -1.9 1.2 1.0 1.5
Height 0.6 11.5 18.7 -2.4 2.3 4.3 4.0
Waist Hip Ratio (WHR) 2.3 10.4 15.3 -2.6 2.8 3.9 3.4
Systolic Blood Pressure 0.6 3.0 4.7 1.7 -2.1 -2.2 -0.5
Smoking Status 0.1 0.2 0.5 0.1 0.6 0.7 0.3
Allergy or Eczema 1.6 4.2 6.0 2.4 -2.0 -1.2 -2.3
Cardiovascular Disease 0.0 0.1 0.3 -0.5 -0.1 -0.0 0.3
Hypothyroidism (self reported) 3.6 8.3 10.2 -3.2 3.0 2.6 2.6
Respiratory disease 2.3 5.1 9.3 2.6 -1.6 -1.4 -3.0
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.3 0.1 -0.4 1.1 0.4
Lung FEV1/FVC ratio 0.2 1.1 1.8 -1.0 1.4 1.0 0.7
Lung FVC 0.0 0.1 0.3 0.3 0.1 -0.5 0.1
Neuroticism 0.7 1.7 2.3 1.2 -1.5 -1.5 -1.0
Chronotype (morning person) 1.5 3.5 6.3 -2.2 1.2 1.1 2.5
Hair Pigment 0.1 1.6 2.1 1.0 -1.0 -1.5 -1.4
Tanning 0.1 0.9 1.4 1.1 -0.8 -0.7 -1.2
Hand grip strength (left) 0.8 2.2 3.5 1.9 -1.5 -1.3 -1.2
Number of treatments/medications taken 0.1 0.1 0.2 0.4 -0.4 -0.4 -0.2
Average weekly spirits intake 0.2 0.2 0.3 -0.4 0.3 0.5 0.5
Sensitivity / hurt feelings 1.0 1.7 4.2 1.4 -2.1 -0.6 -0.5
Frequency of depressed mood in last 2 weeks 1.8 2.5 3.3 1.5 -1.5 -1.8 -1.4
Hearing difficulty/problems: Yes 0.2 0.4 1.1 0.0 -0.4 0.3 1.1
Relative age of first facial hair 0.1 0.2 0.7 0.5 -0.3 -0.1 -0.8
Other serious medical condition/disability diagnosed by doctor 3.8 5.0 7.7 -2.3 2.2 1.5 2.8
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.5 -0.6 1.0 0.9 1.2
Ever had hysterectomy (womb removed) 0.7 0.8 2.3 0.7 -0.4 -0.2 -1.5
Systolic blood pressure, automated reading 0.7 1.9 3.2 1.2 -1.8 -1.6 -0.5
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.6 0.4 -0.8 -0.3 -0.2
Angina 0.1 0.1 0.3 0.5 -0.2 -0.3 -0.1
Medication for hormone replacement therapy 0.8 0.9 1.5 -0.7 0.9 1.2 0.8
Vitamin and mineral supplements 0.9 1.3 1.9 -1.4 1.0 0.7 1.3
Supplements: Zinc 0.4 0.4 0.7 0.7 -0.4 -0.5 -0.8
Medication: Co-codamol 0.9 1.0 3.5 0.6 -0.3 -0.2 -1.9
Medication: Metformin 0.2 0.3 0.6 0.5 -0.4 0.7 -0.6
Diabetes (father) 0.3 0.4 1.3 0.4 0.1 1.1 0.2
Diabetes (mother) 0.3 0.4 0.7 0.6 -0.8 -0.8 -0.0
Severe depression (siblings) 1.7 1.9 2.5 1.3 -0.9 -1.5 -1.6
Pack years adult smoking proportion 0.9 1.4 2.8 1.3 -1.1 0.1 -1.7
Impedance of leg (right) 0.2 0.9 1.3 0.8 -1.0 -0.8 -1.1
Leg fat-free mass (left) 1.4 7.5 9.9 -2.9 2.5 2.4 3.1
Trunk fat percentage 0.6 2.5 5.3 -2.3 1.2 0.9 1.5
Hand grip strength (right) 0.2 0.5 1.0 1.0 -0.6 -0.1 -0.8
Townsend deprivation index at recruitment 0.9 1.3 2.0 -1.4 1.4 1.0 0.3
Current tobacco smoking 0.1 0.1 0.3 0.6 -0.4 -0.1 -0.0
Average weekly fortified wine intake 0.5 0.5 1.0 0.6 -0.7 -1.0 0.5
Maternal smoking around birth 0.9 1.3 3.9 -0.0 0.3 2.0 1.1
Fed-up feelings 0.1 0.1 0.5 -0.1 -0.3 -0.0 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 3.0 4.0 5.1 2.1 -2.0 -2.3 -1.6
Relative age voice broke 0.8 1.2 2.0 1.4 -1.4 -0.5 -0.8
Taking other prescription medications 0.2 0.3 0.9 -0.3 0.9 0.4 -0.1
Age when periods started (menarche) 0.3 0.7 1.9 0.2 -0.4 -1.4 -0.8
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.9 -0.5 1.0 -0.0 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.1 3.8 1.9 -1.2 -0.9 -1.6
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 -0.4 0.1 0.2 -0.2
Qualifications: CSEs or equivalent 0.2 0.3 0.7 -0.4 0.1 0.9 0.3
Serious illness, injury or assault to yourself 3.4 4.1 5.8 -2.4 2.2 1.7 1.8
High blood pressure 0.4 1.1 2.1 0.6 -1.3 -1.4 -0.5
Hayfever, allergic rhinitis or eczema 0.5 1.2 2.5 1.2 -0.8 -0.4 -1.6
Multivitamins +/- minerals 0.5 0.6 0.8 0.9 -0.7 -0.7 -0.9
Stomach or abdominal pain in last month 0.8 0.9 1.7 -0.7 1.1 0.6 1.3
Supplements: Glucosamine 0.2 0.2 0.7 -0.2 0.3 0.0 0.8
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.7 -0.4 0.4 0.8 -0.0
Medication: Atenolol 0.5 0.6 0.9 -0.9 1.0 0.6 0.7
Medication: Levothyroxine sodium 6.7 11.3 12.5 -3.4 3.4 3.0 3.5
Sitting height 0.5 3.3 4.5 -1.6 1.3 2.1 2.1
Chronic bronchitis/emphysema (father) 0.1 0.1 0.3 -0.0 0.6 0.2 -0.5
High blood pressure (mother) 0.1 0.1 0.2 -0.3 0.4 0.3 0.4
Body mass index (BMI) 0.6 2.5 4.7 -2.2 1.4 0.9 1.6
Impedance of leg (left) 0.1 0.4 0.7 0.5 -0.7 -0.5 -0.8
Leg predicted mass (left) 1.4 7.5 9.7 -2.9 2.5 2.4 3.1
Trunk fat mass 1.1 4.7 7.9 -2.8 1.8 1.6 2.3
Waist circumference 1.9 6.9 8.7 -3.0 2.2 2.4 2.9
Number of incorrect matches in round 0.2 0.3 0.6 0.3 -0.7 -0.8 -0.2
Past tobacco smoking 0.6 1.1 2.2 0.5 -1.3 -1.5 -0.3
Alcohol usually taken with meals 0.3 0.4 0.6 0.7 -0.4 -0.7 -0.8
Nervous feelings 4.9 9.2 10.6 3.0 -3.2 -3.2 -2.7
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 1.8 1.2 -1.1 -1.3 -0.3
Hearing difficulty/problems with background noise 0.7 1.2 2.6 1.3 -0.5 -0.3 -1.6
Hair/balding pattern: Pattern 2 0.3 0.4 0.9 -0.9 0.6 0.7 0.1
Had menopause 0.7 0.9 1.5 -1.1 0.8 1.2 0.5
Had other major operations 0.1 0.1 0.4 -0.0 -0.1 0.6 0.3
Forced vital capacity (FVC) 0.4 1.7 2.4 -1.1 1.3 1.6 1.3
Heel bone mineral density (BMD) T-score, automated (right) 2.7 6.1 8.2 2.9 -2.1 -2.3 -2.5
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.2 0.4 -0.6 -1.1 -0.5
Qualifications: None of the above 1.9 4.1 6.4 -1.9 1.2 2.3 2.5
Financial difficulties in last 2 years 0.2 0.3 0.9 -0.9 0.6 -0.3 0.1
Mouth/teeth dental problems 1.5 2.3 5.0 -1.5 1.3 0.5 2.2
Heart attack 0.2 0.2 0.6 -0.4 0.3 -0.1 0.8
Allergy 1.1 2.6 5.4 -1.9 1.0 0.5 2.3
Pain all over the body in last month 0.3 0.3 1.2 -0.3 -0.0 0.2 1.1
Diabetes (self-reported) 0.3 0.5 0.9 0.8 -0.9 0.5 -0.2
Hayfever/allergic rhinitis (self-reported) 1.7 2.3 3.7 1.6 -1.1 -1.2 -1.9
Medication: Ramipril 0.0 0.1 0.1 -0.3 0.2 0.1 0.2
Medication: Simvastatin 1.8 2.7 4.1 1.8 -2.0 -1.0 -1.6
Fluid intelligence score 1.8 3.7 6.7 1.7 -1.7 -1.5 -2.6
Illnesses of siblings 0.1 0.1 0.2 0.3 0.0 -0.0 -0.4
Neuroticism score 1.8 3.7 4.7 1.8 -2.2 -1.9 -1.7
Weight 1.5 7.6 9.7 -3.1 2.5 2.4 2.9
Impedance of arm (right) 0.8 3.7 5.2 1.6 -2.3 -2.1 -1.7
Arm fat percentage (right) 0.3 1.1 3.2 -1.8 0.5 0.2 1.0
Trunk fat-free mass 1.6 9.4 11.9 -2.8 2.9 3.0 3.5
Hip circumference 0.6 2.7 5.2 -2.3 1.3 1.0 1.7
Time employed in main current job 2.2 2.5 3.6 1.9 -1.6 -1.8 -0.8
Alcohol intake versus 10 years previously 0.4 0.6 1.2 -0.6 0.6 1.1 0.8
Father’s age at death 2.8 3.7 5.6 2.1 -1.6 -1.5 -2.4
Worrier / anxious feelings 1.1 2.0 3.6 1.3 -1.4 -1.9 -0.9
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.4 0.5 -0.4 -0.5 -0.6
Falls in the last year 0.4 0.5 0.9 -0.9 1.0 0.6 -0.1
Hair/balding pattern: Pattern 3 0.1 0.1 0.4 0.2 0.1 0.6 0.2
Number of live births 0.3 0.4 1.4 -0.3 0.2 1.2 0.0
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 2.4 -1.4 1.5 1.4 1.5
Pulse rate 1.7 2.8 4.5 1.6 -1.8 -2.1 -0.9
Happiness 4.7 5.7 7.9 2.4 -2.4 -1.9 -2.8
Noisy workplace 0.0 0.0 0.1 -0.1 0.3 0.3 -0.1
Qualifications: A levels/AS levels or equivalent 1.0 2.2 3.5 1.4 -0.7 -1.7 -1.9
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.0 1.0 -1.0 -0.5 -0.9
Mouth/teeth dental problems: Dentures 1.3 2.2 3.7 1.7 -1.1 0.9 -1.9
Asthma 1.2 2.4 4.0 2.0 -1.0 -0.9 -2.0
Medication: Ibuprofen (e.g. Nurofen) 2.0 2.5 4.6 2.2 -1.5 -1.4 -1.1
Medication: Cholesterol lowering 0.1 0.1 0.2 0.4 -0.4 -0.1 0.4
Depression (self-reported) 2.0 2.4 3.1 1.7 -1.4 -1.8 -1.2
Medication: Lansoprazole 2.8 3.2 7.2 1.5 -1.4 -1.2 -2.7
Prospective memory result 0.4 0.5 0.7 0.6 -0.5 -0.9 -0.7
Lung cancer (father) 0.4 0.5 1.2 0.4 -1.1 -0.6 -0.6
Illnesses of mother 0.2 0.2 0.7 -0.5 0.1 0.2 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 3.1 -1.6 1.4 1.3 1.7
Pulse wave Arterial Stiffness index 0.3 0.3 0.6 0.7 -0.5 0.1 -0.8
Impedance of arm (left) 0.6 2.7 3.5 1.5 -1.9 -1.6 -1.6
Arm fat mass (right) 1.2 5.0 8.2 -2.9 1.9 1.6 2.3
Trunk predicted mass 1.7 9.5 12.0 -2.8 2.9 3.1 3.5
Standing height 1.0 9.8 13.3 -2.6 2.6 3.5 3.6
Length of working week for main job 0.4 0.4 1.1 0.7 -0.4 -1.0 0.1
Exposure to tobacco smoke at home 0.0 0.0 0.0 0.2 -0.2 0.1 0.2
Breastfed as a baby 0.1 0.2 0.5 0.1 -0.0 -0.3 -0.7
Tense / ‘highly strung’ 1.0 1.6 2.2 1.5 -1.4 -0.7 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 2.9 1.3 -0.9 -1.1 -1.7
Hair/balding pattern: Pattern 4 0.8 1.8 2.4 1.5 -1.6 -1.3 -0.9
Birth weight of first child 0.9 1.6 2.3 -1.2 1.4 0.7 1.5
Peak expiratory flow (PEF) 1.6 3.6 5.5 -1.7 2.3 1.8 1.7
Pulse wave reflection index 0.8 1.0 2.5 -0.5 1.1 1.6 0.3
Ever highly irritable/argumentative for 2 days 0.0 0.0 0.1 0.2 -0.1 -0.1 -0.3
Loud music exposure frequency 0.1 0.1 0.2 0.3 -0.1 -0.0 0.5
Qualifications: O levels/GCSEs or equivalent 0.3 0.6 1.4 -0.9 1.2 0.2 0.3
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.6 0.4 -0.5 -1.3 -0.7
Blood clot in the leg (DVT) 0.2 0.3 0.4 0.6 -0.4 0.3 -0.7
Medication: Paracetamol 0.4 0.6 1.6 -1.0 1.3 -0.0 0.1
Headache pain in last month 1.3 2.2 3.1 1.4 -1.3 -1.7 -1.3
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.1 0.4 -0.0 -0.3 -1.1
Glaucoma (self-reported) 0.9 1.1 1.4 1.1 -1.2 -1.1 -0.8
Gout (self-reported) 0.3 0.4 0.6 -0.5 0.6 0.8 0.6
Hypothyroidism/myxoedema (self-reported) 4.4 8.5 10.2 -3.2 3.1 2.8 2.6
Medication: Amlodipine 0.0 0.0 0.1 -0.3 0.2 0.2 -0.0
Medication: Ventolin 100micrograms inhaler 0.0 0.0 0.1 0.3 0.0 0.3 0.1
Birth weight 0.3 0.6 1.4 0.3 0.1 -1.2 -1.0
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.6 0.7 -0.0 0.8 -1.6
High blood pressure (siblings) 0.2 0.3 0.6 0.3 -0.8 -0.5 0.3
Forced vital capacity (FVC), Best measure 0.6 2.2 3.0 -1.4 1.3 1.4 1.7
Body fat percentage 0.8 3.2 6.8 -2.6 1.4 1.0 1.7
Leg fat percentage (right) 0.8 3.0 6.7 -2.6 1.5 0.9 1.6
Arm fat-free mass (right) 2.2 11.3 12.0 -3.3 3.3 3.5 3.4
Exposure to tobacco smoke outside home 2.3 3.1 3.9 -1.6 2.0 1.7 1.7
Comparative body size at age 10 0.8 2.2 3.6 -1.2 1.9 1.7 0.8
Number of full brothers 2.1 2.6 3.2 -1.6 1.5 1.6 1.8
Worry too long after embarrassment 1.6 2.7 3.9 2.0 -1.9 -1.3 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 1.0 -0.9 1.0 0.6 0.9
Wheeze or whistling in the chest in last year 1.2 2.2 4.2 1.6 -1.1 -0.9 -2.0
Number of children fathered 1.4 1.5 2.2 -1.2 1.0 1.2 1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.2 0.3 0.2 0.2 -0.5 0.5
Age at first live birth 2.6 4.5 9.0 1.6 -2.1 -3.0 -1.5
Pulse wave peak to peak time 0.6 0.7 1.3 -1.0 0.8 0.2 1.1
Health satisfaction 0.1 0.1 0.1 0.1 -0.4 -0.2 -0.3
Shortness of breath walking on level ground 0.6 0.7 0.8 0.9 -0.7 -0.8 -0.9
Qualifications: College or University degree 2.8 8.8 15.6 2.5 -1.7 -3.2 -4.0
Eye problems/disorders: None of the above 0.2 0.2 0.7 0.1 -0.1 -0.8 -0.3
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.4 -0.7 0.4 -0.1 -0.3
Emphysema/chronic bronchitis 0.4 0.5 1.3 0.1 0.8 1.1 0.1
Medication for pain relief, constipation, heartburn 0.6 1.0 2.1 1.0 -1.4 -0.6 -0.7
Neck or shoulder pain in last month 1.7 2.5 2.7 -1.6 1.7 1.5 1.5
Medication: Blood pressure 0.3 0.5 1.4 -0.5 0.2 0.6 1.2
Angina (self-reported) 0.2 0.2 0.6 0.8 -0.4 -0.4 -0.3
Migraine (self-reported) 0.9 1.1 2.1 -1.1 1.5 0.9 0.6
Medication: Ibuprofen 3.9 4.7 7.3 2.7 -1.9 -2.1 -1.8
Medication: Allopurinol 0.7 0.9 1.4 -1.1 1.1 1.2 0.2
Medication: Omeprazole 0.1 0.1 0.4 0.2 0.2 -0.0 -0.6
Medication: Seretide 50 evohaler 4.3 5.0 7.8 -2.1 2.0 1.8 2.8
Mean time to correctly identify matches 0.1 0.2 0.4 -0.6 -0.1 0.2 -0.6
Heart disease (mother) 0.4 0.5 1.3 -0.6 0.5 1.1 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 2.0 1.0 -0.9 -1.4 -0.9
Whole body fat mass 1.5 6.4 10.2 -3.2 2.2 2.0 2.5
Leg fat mass (right) 1.9 7.5 11.8 -3.4 2.5 1.9 2.9
Arm predicted mass (right) 2.3 11.6 12.9 -3.3 3.4 3.4 3.6
Pulse rate, automated reading 1.8 5.9 8.3 2.1 -2.6 -2.9 -2.0
Alcohol intake frequency. 0.0 0.1 0.2 -0.2 -0.3 0.4 -0.1
Comparative height size at age 10 0.6 3.3 5.8 -1.4 1.4 1.9 2.4
Number of full sisters 0.4 0.4 1.0 -1.0 0.3 0.8 0.1
Suffer from ‘nerves’ 2.9 4.5 6.1 2.4 -2.5 -1.2 -2.1
Overall health rating 1.1 2.4 3.5 -1.9 1.4 0.8 1.8
Chest pain or discomfort 0.1 0.2 0.2 -0.4 0.4 -0.3 -0.5
Had major operations 0.2 0.2 0.6 -0.1 0.3 -0.4 0.8
Age at last live birth 1.4 2.1 4.2 0.9 -1.6 -2.0 -0.9
Family relationship satisfaction 5.0 6.2 8.4 2.6 -2.4 -2.0 -2.9
Leg pain on walking 0.4 0.5 0.9 -0.6 0.4 0.7 1.0
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.5 3.5 -1.1 0.8 1.9 0.9
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.1 0.3 0.1 -0.0 -0.0
Illness, injury, bereavement, stress in last 2 years 1.9 2.3 3.3 1.8 -1.7 -1.2 -1.3
Medication: Aspirin 0.1 0.1 0.3 0.1 -0.3 -0.5 -0.3
Supplements: Vitamin C 0.3 0.4 0.5 0.7 -0.5 -0.6 -0.6
Knee pain experienced in last month 0.0 0.0 0.0 0.0 0.1 0.2 -0.1
Hypertension (Self-reported) 0.3 0.8 1.4 0.5 -1.2 -1.1 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.9 -0.0 0.1 -0.8 -1.4
Illnesses of father: Heart disease 0.8 1.2 1.7 -1.3 1.2 1.1 0.5
Illnesses of siblings: Diabetes 1.7 2.1 2.8 -1.7 1.0 1.5 1.6
Smoking status: Previous 1.8 2.7 4.0 -1.5 2.0 2.0 0.8
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.4 5.6 -1.5 0.9 1.0 2.4
Whole body fat-free mass 1.6 9.2 11.8 -3.0 2.8 2.9 3.4
Leg fat-free mass (right) 1.7 8.8 11.1 -3.0 2.8 2.7 3.3
Arm fat percentage (left) 0.3 1.2 3.2 -1.8 0.7 0.3 1.0
Average weekly red wine intake 1.3 2.0 3.0 1.7 -1.2 -0.9 -1.6
Handedness (chirality/laterality): Left-handed 1.4 1.7 2.7 1.1 -1.2 -1.6 -1.3
Mood swings 0.1 0.3 0.6 0.5 -0.8 -0.5 0.1
Loneliness, isolation 0.1 0.2 0.5 0.2 -0.7 -0.3 -0.4
Long-standing illness, disability or infirmity 0.4 0.5 1.1 -0.5 0.5 0.7 1.0
Ever had bowel cancer screening 0.4 0.5 1.3 -0.6 0.4 0.4 1.1
Diabetes diagnosed by doctor 0.4 0.6 1.0 1.0 -1.0 0.2 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 2.7 -1.4 1.5 0.7 1.6
Friendships satisfaction 1.6 2.0 3.0 1.6 -1.3 -0.8 -1.7
Qualifications: nursing, teaching 4.1 6.3 10.7 2.3 -2.1 -2.3 -3.3
Commuting to job workplace: Walk 1.3 1.4 2.1 0.6 -1.3 -1.5 -1.3
Eye problems/disorders: Cataract 0.1 0.1 0.2 0.3 -0.4 0.3 0.1
Mouth/teeth dental problems: Mouth ulcers 0.7 1.2 1.8 0.6 -0.9 -1.3 -1.3
Medication for cholesterol 0.0 0.0 0.1 -0.0 0.1 0.1 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.2 -0.5 0.4 0.3 0.4
Back pain experienced in last month 0.3 0.5 0.9 0.8 -1.0 -0.1 -0.6
Mineral and other dietary supplements 0.3 0.5 1.3 0.7 -0.4 0.1 -1.1
Breast cancer (self-reported) 1.6 2.0 3.0 1.3 -1.3 -1.7 -1.2
Asthma (self-reported) 1.5 3.1 4.8 2.1 -1.3 -1.2 -2.2
Osteoporosis (self-reported) 1.7 2.1 2.6 -1.5 1.4 1.4 1.6
Osteoarthritis (self-reported) 0.1 0.2 0.5 0.1 0.7 0.5 -0.2
Medication: Aspirin 0.1 0.1 0.2 -0.5 0.1 0.2 0.1
Medication: Gliclazide 0.1 0.1 0.3 -0.2 -0.2 0.5 0.3
Illnesses of father: None of the above (group 1) 0.1 0.1 0.2 -0.3 0.1 0.0 0.5
Smoking status: Current 0.0 0.1 0.2 0.5 -0.3 0.0 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 1.6 -1.3 1.3 0.5 0.7
Whole body water mass 1.6 9.0 11.6 -2.9 2.8 2.8 3.4
Leg predicted mass (right) 1.7 9.0 11.3 -3.1 2.8 2.7 3.4
Arm fat mass (left) 0.9 3.8 6.3 -2.5 1.7 1.5 1.9
Number of self-reported non-cancer illnesses 1.0 1.7 2.9 1.7 -0.9 -1.0 -1.5
Average weekly champagne plus white wine intake 2.3 3.1 5.2 1.6 -1.6 -2.3 -1.5
Miserableness 0.2 0.4 0.8 -0.9 0.7 0.3 0.5
Guilty feelings 1.2 1.9 3.0 1.3 -1.7 -1.5 -0.8
Wears glasses or contact lenses 5.5 6.3 10.5 2.5 -2.4 -1.7 -3.2
Ever taken oral contraceptive pill 0.7 0.8 1.2 -0.8 1.1 0.8 0.9
Hearing aid user 0.2 0.2 0.5 0.4 -0.7 0.5 0.0
Mother’s age at death 0.2 0.3 0.9 0.3 0.2 -0.0 -0.9
Financial situation satisfaction 2.7 3.3 5.7 1.5 -1.5 -1.8 -2.4
Tinnitus: Yes, now most or all of the time 0.3 0.4 0.7 -0.4 0.8 0.7 0.5
Commuting to job workplace: Public transport 0.4 0.4 0.9 -0.7 0.9 -0.1 -0.6
Eye problems/disorders: Glaucoma 0.1 0.1 0.3 0.3 0.1 0.2 0.6
Medication: Blood pressure 0.4 0.7 1.2 0.4 -0.7 -1.0 -1.1
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.3 0.3 -0.6 0.4 -0.2
Supplements: Fish oil (including cod liver oil) 0.7 0.9 3.1 -0.7 0.2 -0.2 1.8
High cholesterol (Self-reported) 0.4 0.8 1.8 0.8 -1.3 -0.6 -0.6
Medication: Bendroflumethiazide 0.0 0.0 0.1 -0.1 -0.0 0.1 0.3
Medication: Paracetamol 0.3 0.5 1.1 0.3 -0.1 -1.0 -0.9
Medication: Lisinopril 0.2 0.2 0.4 0.6 -0.4 -0.2 -0.4
Medication: Atorvastatin 0.0 0.1 0.2 0.0 -0.2 -0.0 0.5
Illnesses of father: High blood pressure 0.1 0.2 0.3 0.4 -0.6 -0.4 0.1
Alcohol drinker status: Never 0.0 0.0 0.0 -0.2 -0.0 -0.0 -0.2
Ever smoked 0.3 0.6 1.0 -0.4 1.0 0.9 0.6
Basal metabolic rate 1.7 9.3 11.8 -3.1 2.8 2.8 3.4
Leg fat percentage (left) 0.9 3.4 6.9 -2.6 1.6 1.1 1.7
Arm fat-free mass (left) 2.1 10.7 12.6 -3.3 3.1 3.1 3.5
Number of operations (self-reported) 0.6 0.9 1.5 1.2 -0.8 -0.5 -1.2
Average weekly beer plus cider intake 0.3 0.5 1.0 -0.2 0.5 0.9 1.0
Irritability 0.3 0.5 1.0 -1.0 0.4 0.3 0.8
Risk taking 2.1 3.1 5.6 -1.3 1.5 2.4 1.6
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.3 0.9 -0.6 -0.4 -1.5
Fractured/broken bones in last 5 years 0.8 1.0 1.4 -0.9 1.2 1.1 0.6
Age started oral contraceptive pill 1.3 1.7 2.5 -1.3 1.0 1.2 1.6
Diastolic blood pressure, automated reading 0.2 0.5 1.2 -0.8 0.3 0.2 1.1
Ever depressed for a whole week 0.1 0.1 0.3 0.2 0.3 -0.6 0.0
Unable to work because of sickness or disability 1.3 1.6 2.6 -1.6 1.4 0.9 1.1
Commuting to job workplace: Cycle 0.4 0.5 0.6 -0.7 0.8 0.8 0.5
Myopia 2.5 3.6 6.0 1.9 -1.3 -1.7 -2.5
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.7 -0.5 1.0 1.3 0.6
Cholesterol lowering medication 0.2 0.3 0.4 0.4 -0.7 -0.5 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.0 0.6 -0.3 -0.7 -1.0
Pain experienced in last month 0.1 0.2 0.4 -0.2 -0.1 -0.7 -0.7
Supplements: Calcium 0.2 0.3 0.5 -0.5 0.5 0.2 -0.7
Basal cell carcinoma (self-reported) 0.1 0.2 0.3 0.3 -0.4 0.6 -0.3
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.9 -0.8 0.7 0.4 1.0
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.3 0.5 -0.3 0.5 -0.5
Heart disease (siblings) 0.3 0.4 0.5 -0.5 0.5 0.7 0.7
Alcohol drinker status: Previous 0.4 0.5 1.7 0.3 -0.2 -0.2 -1.3
Pack years of smoking 0.9 1.3 2.3 1.4 -1.0 0.3 -1.5
Impedance of whole body 0.3 1.5 2.0 1.1 -1.4 -1.1 -1.3
Leg fat mass (left) 2.0 7.9 12.3 -3.5 2.6 2.0 2.9
Arm predicted mass (left) 2.2 11.3 13.2 -3.3 3.2 3.3 3.6