Hub : Genes

HSPA2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0750	0.0320	0.0067	0.006	NA	0.019	NA	0.026	0.1100	NA	0.012	NA	0.0044
2	GTEx	Lung	0.0761	0.0340	0.0064	0.032	NA	0.006	NA	0.023	0.0017	NA	0.099	NA	0.0068
3	GTEx	Nerve Tibial	0.0996	0.0391	0.0011	0.011	NA	0.010	NA	0.002	0.0550	NA	0.057	NA	0.2100
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0432	0.0263	0.0017	0.022	0.012	0.007	NA	0.017	0.0013	0.015	0.043	NA	0.0043

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.4	0.7	0.8	-0.9	-0.3	0.1
Bipolar Disorder or Schizophrenia	1.8	4.4	6.4	2.5	-2.2	-2.0	-1.6
Depressed Affect (Nagel 2018)	0.3	0.6	1.1	-1.1	0.6	-0.1	1.1
Depression (Nagel 2018)	1.8	2.7	3.6	1.8	-1.7	-1.9	-1.0
Intelligence (Savage-Jansen 2018)	1.0	3.0	7.0	1.5	-1.0	-1.4	-2.7
Neuroticism (Nagel 2018)	0.9	2.1	3.3	1.3	-1.8	-1.7	-0.7
Schizophrenia (2018)	2.5	5.3	6.7	2.6	-2.2	-2.3	-2.1
Schizophrenia vs Biploar Disorder	1.0	1.3	1.7	1.3	-1.1	-0.9	-1.1
Worry (Nagel 2018)	2.3	4.9	6.8	2.4	-2.6	-2.3	-1.4
Alzheimer’s Disease (in mother)	0.8	1.0	1.7	1.3	-1.0	-0.8	-0.8
Alzheimer’s Disease (in father)	2.1	2.3	3.4	1.7	-1.8	-1.3	-1.0
Alzheimer’s Disease (including proxy)	3.3	4.7	6.2	2.5	-2.3	-2.0	-1.9
Crohns Disease (2017)	3.4	7.4	8.0	2.8	-2.7	-2.7	-2.7
Irritable Bowel Disease (IBD)	2.0	4.7	5.5	2.3	-2.1	-2.2	-2.0
Ulcerative Colitis (UC)	0.9	1.6	2.2	1.5	-1.3	-1.2	-1.1
Major Depression (MDD)	1.2	1.5	2.6	1.3	-0.6	-1.6	-1.0
Reaction Time	0.1	0.2	0.7	-0.8	0.2	0.2	-0.1
Verbal and Numeric Reasoning (VNR)	0.9	2.1	7.9	0.6	-0.4	-0.3	-2.8
Breast Cancer	0.1	0.3	0.9	0.2	-0.2	0.2	-0.9
Ovarian Cancer	1.0	1.3	2.4	1.1	-1.0	-0.8	-1.5
Prostate Cancer	0.7	1.0	2.4	1.0	-0.2	-0.9	-1.6
Age at First Birth	4.2	6.1	6.8	2.3	-2.6	-2.5	-2.5
Bipolar Disorder (2011)	0.3	0.2	0.5	-0.5	0.1	0.4	0.7
Body Mass Index (BMI) (2010)	1.9	2.5	3.2	-1.6	1.8	1.6	1.3
Coronary Artery Disease (CAD)	0.6	0.7	1.5	0.7	-0.8	-1.2	-0.5
Crohns Disease (2012)	2.0	3.3	4.0	2.0	-1.9	-1.8	-1.6
Mean Putamen Volume	0.3	0.3	0.9	0.9	-0.2	-0.3	0.3
Fasting Glucose	1.1	1.3	4.2	-0.8	0.3	0.1	2.0
HbA1C	0.5	0.5	1.3	0.7	-0.5	-0.3	-1.1
HDL Cholesterol	0.5	0.8	1.2	0.8	-1.1	-1.1	-0.7
LDL Cholesterol	0.3	0.4	0.9	0.6	-0.7	-0.1	-0.9
Lupus	0.4	0.7	1.9	-0.7	1.4	0.3	0.4
Neuroticism (2016)	2.3	3.3	5.7	2.0	-2.4	-1.2	-1.5
Primary Biliary Cirrhosis	1.8	2.5	4.3	-1.8	1.5	0.7	2.1
Rheumatoid Arthritis	1.4	1.9	3.1	-1.3	1.0	1.3	1.8
Schizophrenia (2014)	4.2	9.3	11.1	3.3	-3.1	-3.0	-2.8
Triglycerides	0.1	0.2	0.6	0.3	-0.1	0.0	0.8
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	-0.4	0.2	-0.2	-0.2
Ulcerative Colitis	0.1	0.1	0.5	-0.1	0.1	0.1	0.7
Blood Eosinophil Count	0.6	4.6	11.2	1.7	-1.2	-1.6	-3.4
Blood Platelet Count	0.0	0.4	0.8	0.1	0.9	-0.8	-0.1
Blood Red Count	0.4	4.1	11.3	-1.0	0.9	3.4	1.8
Blood White Count	1.6	11.9	14.9	3.9	-3.7	-2.3	-3.8
Heel T-Score	4.4	35.2	42.5	6.5	-5.3	-5.8	-6.0
BMI	0.4	2.1	3.7	-1.9	1.2	1.0	1.5
Height	0.6	11.5	18.7	-2.4	2.3	4.3	4.0
Waist Hip Ratio (WHR)	2.3	10.4	15.3	-2.6	2.8	3.9	3.4
Systolic Blood Pressure	0.6	3.0	4.7	1.7	-2.1	-2.2	-0.5
Smoking Status	0.1	0.2	0.5	0.1	0.6	0.7	0.3
Allergy or Eczema	1.6	4.2	6.0	2.4	-2.0	-1.2	-2.3
Cardiovascular Disease	0.0	0.1	0.3	-0.5	-0.1	-0.0	0.3
Hypothyroidism (self reported)	3.6	8.3	10.2	-3.2	3.0	2.6	2.6
Respiratory disease	2.3	5.1	9.3	2.6	-1.6	-1.4	-3.0
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.3	0.1	-0.4	1.1	0.4
Lung FEV1/FVC ratio	0.2	1.1	1.8	-1.0	1.4	1.0	0.7
Lung FVC	0.0	0.1	0.3	0.3	0.1	-0.5	0.1
Neuroticism	0.7	1.7	2.3	1.2	-1.5	-1.5	-1.0
Chronotype (morning person)	1.5	3.5	6.3	-2.2	1.2	1.1	2.5
Hair Pigment	0.1	1.6	2.1	1.0	-1.0	-1.5	-1.4
Tanning	0.1	0.9	1.4	1.1	-0.8	-0.7	-1.2
Hand grip strength (left)	0.8	2.2	3.5	1.9	-1.5	-1.3	-1.2
Number of treatments/medications taken	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.2
Average weekly spirits intake	0.2	0.2	0.3	-0.4	0.3	0.5	0.5
Sensitivity / hurt feelings	1.0	1.7	4.2	1.4	-2.1	-0.6	-0.5
Frequency of depressed mood in last 2 weeks	1.8	2.5	3.3	1.5	-1.5	-1.8	-1.4
Hearing difficulty/problems: Yes	0.2	0.4	1.1	0.0	-0.4	0.3	1.1
Relative age of first facial hair	0.1	0.2	0.7	0.5	-0.3	-0.1	-0.8
Other serious medical condition/disability diagnosed by doctor	3.8	5.0	7.7	-2.3	2.2	1.5	2.8
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.5	-0.6	1.0	0.9	1.2
Ever had hysterectomy (womb removed)	0.7	0.8	2.3	0.7	-0.4	-0.2	-1.5
Systolic blood pressure, automated reading	0.7	1.9	3.2	1.2	-1.8	-1.6	-0.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	0.4	-0.8	-0.3	-0.2
Angina	0.1	0.1	0.3	0.5	-0.2	-0.3	-0.1
Medication for hormone replacement therapy	0.8	0.9	1.5	-0.7	0.9	1.2	0.8
Vitamin and mineral supplements	0.9	1.3	1.9	-1.4	1.0	0.7	1.3
Supplements: Zinc	0.4	0.4	0.7	0.7	-0.4	-0.5	-0.8
Medication: Co-codamol	0.9	1.0	3.5	0.6	-0.3	-0.2	-1.9
Medication: Metformin	0.2	0.3	0.6	0.5	-0.4	0.7	-0.6
Diabetes (father)	0.3	0.4	1.3	0.4	0.1	1.1	0.2
Diabetes (mother)	0.3	0.4	0.7	0.6	-0.8	-0.8	-0.0
Severe depression (siblings)	1.7	1.9	2.5	1.3	-0.9	-1.5	-1.6
Pack years adult smoking proportion	0.9	1.4	2.8	1.3	-1.1	0.1	-1.7
Impedance of leg (right)	0.2	0.9	1.3	0.8	-1.0	-0.8	-1.1
Leg fat-free mass (left)	1.4	7.5	9.9	-2.9	2.5	2.4	3.1
Trunk fat percentage	0.6	2.5	5.3	-2.3	1.2	0.9	1.5
Hand grip strength (right)	0.2	0.5	1.0	1.0	-0.6	-0.1	-0.8
Townsend deprivation index at recruitment	0.9	1.3	2.0	-1.4	1.4	1.0	0.3
Current tobacco smoking	0.1	0.1	0.3	0.6	-0.4	-0.1	-0.0
Average weekly fortified wine intake	0.5	0.5	1.0	0.6	-0.7	-1.0	0.5
Maternal smoking around birth	0.9	1.3	3.9	-0.0	0.3	2.0	1.1
Fed-up feelings	0.1	0.1	0.5	-0.1	-0.3	-0.0	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	3.0	4.0	5.1	2.1	-2.0	-2.3	-1.6
Relative age voice broke	0.8	1.2	2.0	1.4	-1.4	-0.5	-0.8
Taking other prescription medications	0.2	0.3	0.9	-0.3	0.9	0.4	-0.1
Age when periods started (menarche)	0.3	0.7	1.9	0.2	-0.4	-1.4	-0.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.9	-0.5	1.0	-0.0	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	3.8	1.9	-1.2	-0.9	-1.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.4	0.1	0.2	-0.2
Qualifications: CSEs or equivalent	0.2	0.3	0.7	-0.4	0.1	0.9	0.3
Serious illness, injury or assault to yourself	3.4	4.1	5.8	-2.4	2.2	1.7	1.8
High blood pressure	0.4	1.1	2.1	0.6	-1.3	-1.4	-0.5
Hayfever, allergic rhinitis or eczema	0.5	1.2	2.5	1.2	-0.8	-0.4	-1.6
Multivitamins +/- minerals	0.5	0.6	0.8	0.9	-0.7	-0.7	-0.9
Stomach or abdominal pain in last month	0.8	0.9	1.7	-0.7	1.1	0.6	1.3
Supplements: Glucosamine	0.2	0.2	0.7	-0.2	0.3	0.0	0.8
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.7	-0.4	0.4	0.8	-0.0
Medication: Atenolol	0.5	0.6	0.9	-0.9	1.0	0.6	0.7
Medication: Levothyroxine sodium	6.7	11.3	12.5	-3.4	3.4	3.0	3.5
Sitting height	0.5	3.3	4.5	-1.6	1.3	2.1	2.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.0	0.6	0.2	-0.5
High blood pressure (mother)	0.1	0.1	0.2	-0.3	0.4	0.3	0.4
Body mass index (BMI)	0.6	2.5	4.7	-2.2	1.4	0.9	1.6
Impedance of leg (left)	0.1	0.4	0.7	0.5	-0.7	-0.5	-0.8
Leg predicted mass (left)	1.4	7.5	9.7	-2.9	2.5	2.4	3.1
Trunk fat mass	1.1	4.7	7.9	-2.8	1.8	1.6	2.3
Waist circumference	1.9	6.9	8.7	-3.0	2.2	2.4	2.9
Number of incorrect matches in round	0.2	0.3	0.6	0.3	-0.7	-0.8	-0.2
Past tobacco smoking	0.6	1.1	2.2	0.5	-1.3	-1.5	-0.3
Alcohol usually taken with meals	0.3	0.4	0.6	0.7	-0.4	-0.7	-0.8
Nervous feelings	4.9	9.2	10.6	3.0	-3.2	-3.2	-2.7
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.8	1.2	-1.1	-1.3	-0.3
Hearing difficulty/problems with background noise	0.7	1.2	2.6	1.3	-0.5	-0.3	-1.6
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	-0.9	0.6	0.7	0.1
Had menopause	0.7	0.9	1.5	-1.1	0.8	1.2	0.5
Had other major operations	0.1	0.1	0.4	-0.0	-0.1	0.6	0.3
Forced vital capacity (FVC)	0.4	1.7	2.4	-1.1	1.3	1.6	1.3
Heel bone mineral density (BMD) T-score, automated (right)	2.7	6.1	8.2	2.9	-2.1	-2.3	-2.5
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.2	0.4	-0.6	-1.1	-0.5
Qualifications: None of the above	1.9	4.1	6.4	-1.9	1.2	2.3	2.5
Financial difficulties in last 2 years	0.2	0.3	0.9	-0.9	0.6	-0.3	0.1
Mouth/teeth dental problems	1.5	2.3	5.0	-1.5	1.3	0.5	2.2
Heart attack	0.2	0.2	0.6	-0.4	0.3	-0.1	0.8
Allergy	1.1	2.6	5.4	-1.9	1.0	0.5	2.3
Pain all over the body in last month	0.3	0.3	1.2	-0.3	-0.0	0.2	1.1
Diabetes (self-reported)	0.3	0.5	0.9	0.8	-0.9	0.5	-0.2
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	3.7	1.6	-1.1	-1.2	-1.9
Medication: Ramipril	0.0	0.1	0.1	-0.3	0.2	0.1	0.2
Medication: Simvastatin	1.8	2.7	4.1	1.8	-2.0	-1.0	-1.6
Fluid intelligence score	1.8	3.7	6.7	1.7	-1.7	-1.5	-2.6
Illnesses of siblings	0.1	0.1	0.2	0.3	0.0	-0.0	-0.4
Neuroticism score	1.8	3.7	4.7	1.8	-2.2	-1.9	-1.7
Weight	1.5	7.6	9.7	-3.1	2.5	2.4	2.9
Impedance of arm (right)	0.8	3.7	5.2	1.6	-2.3	-2.1	-1.7
Arm fat percentage (right)	0.3	1.1	3.2	-1.8	0.5	0.2	1.0
Trunk fat-free mass	1.6	9.4	11.9	-2.8	2.9	3.0	3.5
Hip circumference	0.6	2.7	5.2	-2.3	1.3	1.0	1.7
Time employed in main current job	2.2	2.5	3.6	1.9	-1.6	-1.8	-0.8
Alcohol intake versus 10 years previously	0.4	0.6	1.2	-0.6	0.6	1.1	0.8
Father’s age at death	2.8	3.7	5.6	2.1	-1.6	-1.5	-2.4
Worrier / anxious feelings	1.1	2.0	3.6	1.3	-1.4	-1.9	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.4	0.5	-0.4	-0.5	-0.6
Falls in the last year	0.4	0.5	0.9	-0.9	1.0	0.6	-0.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.4	0.2	0.1	0.6	0.2
Number of live births	0.3	0.4	1.4	-0.3	0.2	1.2	0.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	2.4	-1.4	1.5	1.4	1.5
Pulse rate	1.7	2.8	4.5	1.6	-1.8	-2.1	-0.9
Happiness	4.7	5.7	7.9	2.4	-2.4	-1.9	-2.8
Noisy workplace	0.0	0.0	0.1	-0.1	0.3	0.3	-0.1
Qualifications: A levels/AS levels or equivalent	1.0	2.2	3.5	1.4	-0.7	-1.7	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.0	1.0	-1.0	-0.5	-0.9
Mouth/teeth dental problems: Dentures	1.3	2.2	3.7	1.7	-1.1	0.9	-1.9
Asthma	1.2	2.4	4.0	2.0	-1.0	-0.9	-2.0
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	4.6	2.2	-1.5	-1.4	-1.1
Medication: Cholesterol lowering	0.1	0.1	0.2	0.4	-0.4	-0.1	0.4
Depression (self-reported)	2.0	2.4	3.1	1.7	-1.4	-1.8	-1.2
Medication: Lansoprazole	2.8	3.2	7.2	1.5	-1.4	-1.2	-2.7
Prospective memory result	0.4	0.5	0.7	0.6	-0.5	-0.9	-0.7
Lung cancer (father)	0.4	0.5	1.2	0.4	-1.1	-0.6	-0.6
Illnesses of mother	0.2	0.2	0.7	-0.5	0.1	0.2	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	3.1	-1.6	1.4	1.3	1.7
Pulse wave Arterial Stiffness index	0.3	0.3	0.6	0.7	-0.5	0.1	-0.8
Impedance of arm (left)	0.6	2.7	3.5	1.5	-1.9	-1.6	-1.6
Arm fat mass (right)	1.2	5.0	8.2	-2.9	1.9	1.6	2.3
Trunk predicted mass	1.7	9.5	12.0	-2.8	2.9	3.1	3.5
Standing height	1.0	9.8	13.3	-2.6	2.6	3.5	3.6
Length of working week for main job	0.4	0.4	1.1	0.7	-0.4	-1.0	0.1
Exposure to tobacco smoke at home	0.0	0.0	0.0	0.2	-0.2	0.1	0.2
Breastfed as a baby	0.1	0.2	0.5	0.1	-0.0	-0.3	-0.7
Tense / ‘highly strung’	1.0	1.6	2.2	1.5	-1.4	-0.7	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	2.9	1.3	-0.9	-1.1	-1.7
Hair/balding pattern: Pattern 4	0.8	1.8	2.4	1.5	-1.6	-1.3	-0.9
Birth weight of first child	0.9	1.6	2.3	-1.2	1.4	0.7	1.5
Peak expiratory flow (PEF)	1.6	3.6	5.5	-1.7	2.3	1.8	1.7
Pulse wave reflection index	0.8	1.0	2.5	-0.5	1.1	1.6	0.3
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.3
Loud music exposure frequency	0.1	0.1	0.2	0.3	-0.1	-0.0	0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.6	1.4	-0.9	1.2	0.2	0.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.6	0.4	-0.5	-1.3	-0.7
Blood clot in the leg (DVT)	0.2	0.3	0.4	0.6	-0.4	0.3	-0.7
Medication: Paracetamol	0.4	0.6	1.6	-1.0	1.3	-0.0	0.1
Headache pain in last month	1.3	2.2	3.1	1.4	-1.3	-1.7	-1.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.1	0.4	-0.0	-0.3	-1.1
Glaucoma (self-reported)	0.9	1.1	1.4	1.1	-1.2	-1.1	-0.8
Gout (self-reported)	0.3	0.4	0.6	-0.5	0.6	0.8	0.6
Hypothyroidism/myxoedema (self-reported)	4.4	8.5	10.2	-3.2	3.1	2.8	2.6
Medication: Amlodipine	0.0	0.0	0.1	-0.3	0.2	0.2	-0.0
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	0.3	0.0	0.3	0.1
Birth weight	0.3	0.6	1.4	0.3	0.1	-1.2	-1.0
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.6	0.7	-0.0	0.8	-1.6
High blood pressure (siblings)	0.2	0.3	0.6	0.3	-0.8	-0.5	0.3
Forced vital capacity (FVC), Best measure	0.6	2.2	3.0	-1.4	1.3	1.4	1.7
Body fat percentage	0.8	3.2	6.8	-2.6	1.4	1.0	1.7
Leg fat percentage (right)	0.8	3.0	6.7	-2.6	1.5	0.9	1.6
Arm fat-free mass (right)	2.2	11.3	12.0	-3.3	3.3	3.5	3.4
Exposure to tobacco smoke outside home	2.3	3.1	3.9	-1.6	2.0	1.7	1.7
Comparative body size at age 10	0.8	2.2	3.6	-1.2	1.9	1.7	0.8
Number of full brothers	2.1	2.6	3.2	-1.6	1.5	1.6	1.8
Worry too long after embarrassment	1.6	2.7	3.9	2.0	-1.9	-1.3	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.0	-0.9	1.0	0.6	0.9
Wheeze or whistling in the chest in last year	1.2	2.2	4.2	1.6	-1.1	-0.9	-2.0
Number of children fathered	1.4	1.5	2.2	-1.2	1.0	1.2	1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.3	0.2	0.2	-0.5	0.5
Age at first live birth	2.6	4.5	9.0	1.6	-2.1	-3.0	-1.5
Pulse wave peak to peak time	0.6	0.7	1.3	-1.0	0.8	0.2	1.1
Health satisfaction	0.1	0.1	0.1	0.1	-0.4	-0.2	-0.3
Shortness of breath walking on level ground	0.6	0.7	0.8	0.9	-0.7	-0.8	-0.9
Qualifications: College or University degree	2.8	8.8	15.6	2.5	-1.7	-3.2	-4.0
Eye problems/disorders: None of the above	0.2	0.2	0.7	0.1	-0.1	-0.8	-0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.4	-0.7	0.4	-0.1	-0.3
Emphysema/chronic bronchitis	0.4	0.5	1.3	0.1	0.8	1.1	0.1
Medication for pain relief, constipation, heartburn	0.6	1.0	2.1	1.0	-1.4	-0.6	-0.7
Neck or shoulder pain in last month	1.7	2.5	2.7	-1.6	1.7	1.5	1.5
Medication: Blood pressure	0.3	0.5	1.4	-0.5	0.2	0.6	1.2
Angina (self-reported)	0.2	0.2	0.6	0.8	-0.4	-0.4	-0.3
Migraine (self-reported)	0.9	1.1	2.1	-1.1	1.5	0.9	0.6
Medication: Ibuprofen	3.9	4.7	7.3	2.7	-1.9	-2.1	-1.8
Medication: Allopurinol	0.7	0.9	1.4	-1.1	1.1	1.2	0.2
Medication: Omeprazole	0.1	0.1	0.4	0.2	0.2	-0.0	-0.6
Medication: Seretide 50 evohaler	4.3	5.0	7.8	-2.1	2.0	1.8	2.8
Mean time to correctly identify matches	0.1	0.2	0.4	-0.6	-0.1	0.2	-0.6
Heart disease (mother)	0.4	0.5	1.3	-0.6	0.5	1.1	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.0	1.0	-0.9	-1.4	-0.9
Whole body fat mass	1.5	6.4	10.2	-3.2	2.2	2.0	2.5
Leg fat mass (right)	1.9	7.5	11.8	-3.4	2.5	1.9	2.9
Arm predicted mass (right)	2.3	11.6	12.9	-3.3	3.4	3.4	3.6
Pulse rate, automated reading	1.8	5.9	8.3	2.1	-2.6	-2.9	-2.0
Alcohol intake frequency.	0.0	0.1	0.2	-0.2	-0.3	0.4	-0.1
Comparative height size at age 10	0.6	3.3	5.8	-1.4	1.4	1.9	2.4
Number of full sisters	0.4	0.4	1.0	-1.0	0.3	0.8	0.1
Suffer from ‘nerves’	2.9	4.5	6.1	2.4	-2.5	-1.2	-2.1
Overall health rating	1.1	2.4	3.5	-1.9	1.4	0.8	1.8
Chest pain or discomfort	0.1	0.2	0.2	-0.4	0.4	-0.3	-0.5
Had major operations	0.2	0.2	0.6	-0.1	0.3	-0.4	0.8
Age at last live birth	1.4	2.1	4.2	0.9	-1.6	-2.0	-0.9
Family relationship satisfaction	5.0	6.2	8.4	2.6	-2.4	-2.0	-2.9
Leg pain on walking	0.4	0.5	0.9	-0.6	0.4	0.7	1.0
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	3.5	-1.1	0.8	1.9	0.9
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.3	0.1	-0.0	-0.0
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	3.3	1.8	-1.7	-1.2	-1.3
Medication: Aspirin	0.1	0.1	0.3	0.1	-0.3	-0.5	-0.3
Supplements: Vitamin C	0.3	0.4	0.5	0.7	-0.5	-0.6	-0.6
Knee pain experienced in last month	0.0	0.0	0.0	0.0	0.1	0.2	-0.1
Hypertension (Self-reported)	0.3	0.8	1.4	0.5	-1.2	-1.1	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.9	-0.0	0.1	-0.8	-1.4
Illnesses of father: Heart disease	0.8	1.2	1.7	-1.3	1.2	1.1	0.5
Illnesses of siblings: Diabetes	1.7	2.1	2.8	-1.7	1.0	1.5	1.6
Smoking status: Previous	1.8	2.7	4.0	-1.5	2.0	2.0	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	5.6	-1.5	0.9	1.0	2.4
Whole body fat-free mass	1.6	9.2	11.8	-3.0	2.8	2.9	3.4
Leg fat-free mass (right)	1.7	8.8	11.1	-3.0	2.8	2.7	3.3
Arm fat percentage (left)	0.3	1.2	3.2	-1.8	0.7	0.3	1.0
Average weekly red wine intake	1.3	2.0	3.0	1.7	-1.2	-0.9	-1.6
Handedness (chirality/laterality): Left-handed	1.4	1.7	2.7	1.1	-1.2	-1.6	-1.3
Mood swings	0.1	0.3	0.6	0.5	-0.8	-0.5	0.1
Loneliness, isolation	0.1	0.2	0.5	0.2	-0.7	-0.3	-0.4
Long-standing illness, disability or infirmity	0.4	0.5	1.1	-0.5	0.5	0.7	1.0
Ever had bowel cancer screening	0.4	0.5	1.3	-0.6	0.4	0.4	1.1
Diabetes diagnosed by doctor	0.4	0.6	1.0	1.0	-1.0	0.2	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	2.7	-1.4	1.5	0.7	1.6
Friendships satisfaction	1.6	2.0	3.0	1.6	-1.3	-0.8	-1.7
Qualifications: nursing, teaching	4.1	6.3	10.7	2.3	-2.1	-2.3	-3.3
Commuting to job workplace: Walk	1.3	1.4	2.1	0.6	-1.3	-1.5	-1.3
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.3	-0.4	0.3	0.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	1.8	0.6	-0.9	-1.3	-1.3
Medication for cholesterol	0.0	0.0	0.1	-0.0	0.1	0.1	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.2	-0.5	0.4	0.3	0.4
Back pain experienced in last month	0.3	0.5	0.9	0.8	-1.0	-0.1	-0.6
Mineral and other dietary supplements	0.3	0.5	1.3	0.7	-0.4	0.1	-1.1
Breast cancer (self-reported)	1.6	2.0	3.0	1.3	-1.3	-1.7	-1.2
Asthma (self-reported)	1.5	3.1	4.8	2.1	-1.3	-1.2	-2.2
Osteoporosis (self-reported)	1.7	2.1	2.6	-1.5	1.4	1.4	1.6
Osteoarthritis (self-reported)	0.1	0.2	0.5	0.1	0.7	0.5	-0.2
Medication: Aspirin	0.1	0.1	0.2	-0.5	0.1	0.2	0.1
Medication: Gliclazide	0.1	0.1	0.3	-0.2	-0.2	0.5	0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.3	0.1	0.0	0.5
Smoking status: Current	0.0	0.1	0.2	0.5	-0.3	0.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.6	-1.3	1.3	0.5	0.7
Whole body water mass	1.6	9.0	11.6	-2.9	2.8	2.8	3.4
Leg predicted mass (right)	1.7	9.0	11.3	-3.1	2.8	2.7	3.4
Arm fat mass (left)	0.9	3.8	6.3	-2.5	1.7	1.5	1.9
Number of self-reported non-cancer illnesses	1.0	1.7	2.9	1.7	-0.9	-1.0	-1.5
Average weekly champagne plus white wine intake	2.3	3.1	5.2	1.6	-1.6	-2.3	-1.5
Miserableness	0.2	0.4	0.8	-0.9	0.7	0.3	0.5
Guilty feelings	1.2	1.9	3.0	1.3	-1.7	-1.5	-0.8
Wears glasses or contact lenses	5.5	6.3	10.5	2.5	-2.4	-1.7	-3.2
Ever taken oral contraceptive pill	0.7	0.8	1.2	-0.8	1.1	0.8	0.9
Hearing aid user	0.2	0.2	0.5	0.4	-0.7	0.5	0.0
Mother’s age at death	0.2	0.3	0.9	0.3	0.2	-0.0	-0.9
Financial situation satisfaction	2.7	3.3	5.7	1.5	-1.5	-1.8	-2.4
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.7	-0.4	0.8	0.7	0.5
Commuting to job workplace: Public transport	0.4	0.4	0.9	-0.7	0.9	-0.1	-0.6
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	0.3	0.1	0.2	0.6
Medication: Blood pressure	0.4	0.7	1.2	0.4	-0.7	-1.0	-1.1
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.3	0.3	-0.6	0.4	-0.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.1	-0.7	0.2	-0.2	1.8
High cholesterol (Self-reported)	0.4	0.8	1.8	0.8	-1.3	-0.6	-0.6
Medication: Bendroflumethiazide	0.0	0.0	0.1	-0.1	-0.0	0.1	0.3
Medication: Paracetamol	0.3	0.5	1.1	0.3	-0.1	-1.0	-0.9
Medication: Lisinopril	0.2	0.2	0.4	0.6	-0.4	-0.2	-0.4
Medication: Atorvastatin	0.0	0.1	0.2	0.0	-0.2	-0.0	0.5
Illnesses of father: High blood pressure	0.1	0.2	0.3	0.4	-0.6	-0.4	0.1
Alcohol drinker status: Never	0.0	0.0	0.0	-0.2	-0.0	-0.0	-0.2
Ever smoked	0.3	0.6	1.0	-0.4	1.0	0.9	0.6
Basal metabolic rate	1.7	9.3	11.8	-3.1	2.8	2.8	3.4
Leg fat percentage (left)	0.9	3.4	6.9	-2.6	1.6	1.1	1.7
Arm fat-free mass (left)	2.1	10.7	12.6	-3.3	3.1	3.1	3.5
Number of operations (self-reported)	0.6	0.9	1.5	1.2	-0.8	-0.5	-1.2
Average weekly beer plus cider intake	0.3	0.5	1.0	-0.2	0.5	0.9	1.0
Irritability	0.3	0.5	1.0	-1.0	0.4	0.3	0.8
Risk taking	2.1	3.1	5.6	-1.3	1.5	2.4	1.6
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.3	0.9	-0.6	-0.4	-1.5
Fractured/broken bones in last 5 years	0.8	1.0	1.4	-0.9	1.2	1.1	0.6
Age started oral contraceptive pill	1.3	1.7	2.5	-1.3	1.0	1.2	1.6
Diastolic blood pressure, automated reading	0.2	0.5	1.2	-0.8	0.3	0.2	1.1
Ever depressed for a whole week	0.1	0.1	0.3	0.2	0.3	-0.6	0.0
Unable to work because of sickness or disability	1.3	1.6	2.6	-1.6	1.4	0.9	1.1
Commuting to job workplace: Cycle	0.4	0.5	0.6	-0.7	0.8	0.8	0.5
Myopia	2.5	3.6	6.0	1.9	-1.3	-1.7	-2.5
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.7	-0.5	1.0	1.3	0.6
Cholesterol lowering medication	0.2	0.3	0.4	0.4	-0.7	-0.5	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	0.6	-0.3	-0.7	-1.0
Pain experienced in last month	0.1	0.2	0.4	-0.2	-0.1	-0.7	-0.7
Supplements: Calcium	0.2	0.3	0.5	-0.5	0.5	0.2	-0.7
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	0.3	-0.4	0.6	-0.3
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.9	-0.8	0.7	0.4	1.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.3	0.5	-0.3	0.5	-0.5
Heart disease (siblings)	0.3	0.4	0.5	-0.5	0.5	0.7	0.7
Alcohol drinker status: Previous	0.4	0.5	1.7	0.3	-0.2	-0.2	-1.3
Pack years of smoking	0.9	1.3	2.3	1.4	-1.0	0.3	-1.5
Impedance of whole body	0.3	1.5	2.0	1.1	-1.4	-1.1	-1.3
Leg fat mass (left)	2.0	7.9	12.3	-3.5	2.6	2.0	2.9
Arm predicted mass (left)	2.2	11.3	13.2	-3.3	3.2	3.3	3.6