Hub : Genes

SLC1A5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.3050 0.0550 3.7e-11 0.327 NA 0.324 NA 0.332 3.5e-25 NA 6.9e-25 NA 1.2e-25
2 GTEx Nerve Tibial 0.1551 0.0645 5.5e-03 0.046 NA 0.009 NA 0.009 3.3e-04 NA 7.5e-02 NA 7.3e-02
3 METSIM Adipose 0.1155 0.0378 1.6e-05 0.018 0.042 0.065 0.048 0.024 9.7e-04 6.6e-07 4.9e-10 8.7e-08 1.2e-04
4 YFS Blood 0.0728 0.0205 1.0e-07 0.033 0.034 0.051 0.046 0.044 4.0e-11 2.8e-11 2.2e-16 6.3e-15 3.2e-14
5 TCGA Kidney Renal Papillary Cell Carcinoma 0.0680 0.0350 6.6e-03 0.017 0.033 0.017 NA 0.009 3.4e-02 5.2e-03 3.5e-02 NA 9.2e-02
6 TCGA Brain Lower Grade Glioma 0.0695 0.0335 5.9e-04 0.012 0.031 0.030 NA 0.020 1.3e-02 1.9e-04 2.2e-04 NA 2.2e-03
7 TCGA Prostate Adenocarcinoma 0.0492 0.0236 2.6e-03 -0.001 0.025 0.014 NA 0.006 4.5e-01 9.9e-04 1.2e-02 NA 7.1e-02
8 TCGA Thyroid Carcinoma 0.2230 0.0620 5.8e-06 0.119 0.051 0.105 NA 0.113 1.3e-11 9.0e-06 2.1e-10 NA 4.4e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.1 0.2 0.3 -0.5 0.0 0.1 -0.6 0.6 -0.4 -0.6 0.0
Bipolar Disorder or Schizophrenia 0.4 0.9 3.1 1.8 0.0 -0.5 -0.2 -1.2 1.5 -0.4 0.0
Depressed Affect (Nagel 2018) 0.3 0.7 1.6 1.3 1.0 0.2 0.6 -1.0 0.5 0.1 -1.2
Depression (Nagel 2018) 0.4 0.5 2.1 -0.2 -0.5 0.1 -0.4 0.3 -0.1 1.4 -1.2
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.1 0.6 0.9 0.5 0.3 -0.4 0.0 -0.3 1.0
Neuroticism (Nagel 2018) 0.1 0.2 0.8 0.2 0.2 -0.2 0.3 0.1 -0.1 0.7 -0.9
Schizophrenia (2018) 1.0 2.2 6.9 2.6 0.0 -0.8 0.2 -1.9 2.4 0.1 0.5
Schizophrenia vs Biploar Disorder 0.1 0.2 1.1 0.3 0.0 0.0 1.1 0.0 0.0 0.0 0.0
Worry (Nagel 2018) 0.3 0.6 1.1 -1.1 -1.0 -0.5 0.2 1.0 -0.6 1.0 -0.5
Alzheimer’s Disease (in mother) 2.9 3.4 9.3 2.9 1.9 -0.4 0.0 -3.0 -0.3 -1.9 1.4
Alzheimer’s Disease (in father) 1.8 2.0 5.8 1.7 2.4 -1.2 1.6 -0.4 0.1 0.1 -1.8
Alzheimer’s Disease (including proxy) 2.0 2.9 7.6 2.8 2.5 -1.0 1.8 -2.1 0.3 -0.8 0.6
Crohns Disease (2017) 0.2 0.5 1.3 -1.2 -1.2 0.3 0.3 0.7 -0.0 -0.7 -0.2
Irritable Bowel Disease (IBD) 0.4 1.0 3.0 -1.7 -1.3 -0.6 0.6 1.1 -0.8 -1.0 -0.2
Ulcerative Colitis (UC) 0.8 1.5 3.0 -1.7 -1.2 -1.6 0.0 0.6 -1.6 -1.3 0.2
Major Depression (MDD) 0.6 0.8 3.0 0.6 0.0 1.7 -0.0 1.1 -0.1 0.8 -1.0
Reaction Time 1.4 2.6 5.7 -1.8 -1.6 -0.1 -0.7 2.4 -2.2 -0.3 -1.9
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.5 0.7 0.9 1.1 -1.2 -1.2 0.3 -1.0 -0.0
Breast Cancer 1.1 2.6 7.6 2.1 2.7 1.0 0.2 -0.7 2.8 0.1 0.1
Ovarian Cancer 1.7 2.2 5.8 -2.4 -2.0 -1.8 -0.8 1.7 -0.9 -0.5 0.4
Prostate Cancer 1.7 2.4 4.0 1.9 1.7 1.0 2.0 -1.0 1.8 1.7 0.5
Age at First Birth 0.9 1.2 4.3 0.4 0.0 -0.7 -1.2 -1.4 -1.2 -2.1 0.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.1 0.2 0.5 0.2 0.0 -0.4 -0.1 -0.3 0.7 -0.3 -0.7
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.2 0.3 0.9 -0.5 0.0 -0.8 -0.2 0.4 -0.9 -0.6 0.0
Mean Putamen Volume 1.2 1.3 5.8 -0.1 0.0 1.6 1.1 0.7 -0.3 0.6 -2.4
Fasting Glucose 0.3 0.3 1.5 -0.3 0.0 0.2 0.8 1.2 0.2 0.0 -0.7
HbA1C 0.9 1.0 3.1 0.7 0.0 0.6 -1.8 -1.1 -0.2 -1.7 0.3
HDL Cholesterol 0.1 0.1 0.4 -0.0 0.0 -0.6 0.1 0.3 -0.3 0.6 -0.0
LDL Cholesterol 0.8 1.3 4.0 1.2 0.0 0.2 -0.5 -2.0 -1.1 -1.5 -1.0
Lupus 0.5 0.7 2.8 0.5 0.5 0.2 1.3 0.7 -0.1 0.7 -1.7
Neuroticism (2016) 1.3 1.8 6.0 -0.3 -0.3 -1.0 1.5 0.4 2.4 0.9 2.1
Primary Biliary Cirrhosis 1.3 1.9 4.0 -2.0 0.0 -1.8 -2.0 0.6 -1.7 0.4 0.0
Rheumatoid Arthritis 0.2 0.3 0.5 0.6 0.0 -0.1 -0.6 -0.6 -0.7 -0.6 -0.5
Schizophrenia (2014) 0.4 0.8 2.5 1.6 0.0 -0.1 0.1 -1.4 1.2 -0.6 0.4
Triglycerides 0.9 1.5 4.2 0.5 0.0 -0.1 -2.0 -2.1 -0.4 -1.8 0.5
Type 2 Diabetes (T2D) (2012) 0.7 0.9 3.3 -1.8 0.0 0.0 -0.6 1.2 -0.8 0.3 1.0
Ulcerative Colitis 0.2 0.3 1.9 -1.4 0.0 -0.5 0.6 0.0 0.0 0.0 0.0
Blood Eosinophil Count 0.3 2.0 5.1 -2.0 -2.0 -1.3 0.3 2.2 0.1 0.8 -0.8
Blood Platelet Count 0.6 7.0 14.6 1.6 1.4 -3.0 2.3 2.1 3.8 3.6 -2.1
Blood Red Count 0.3 2.6 13.6 -0.5 0.1 -3.7 -2.2 0.7 0.1 -1.1 0.4
Blood White Count 0.4 2.9 17.9 -1.2 -1.3 -4.2 -0.7 0.5 1.1 0.4 0.3
Heel T-Score 1.2 9.6 30.9 -3.9 -2.8 -0.1 1.6 5.6 1.6 3.9 -1.8
BMI 0.3 1.6 6.0 -0.2 -0.6 2.5 -1.0 -0.7 -1.1 -1.8 0.1
Height 0.8 16.3 41.7 -5.1 -6.5 -1.7 -3.8 -1.3 -5.2 -2.8 2.9
Waist Hip Ratio (WHR) 0.4 1.6 6.5 -1.2 -1.0 -0.3 0.9 2.5 -0.3 1.7 -0.5
Systolic Blood Pressure 0.2 0.8 2.9 0.6 -0.0 0.3 -1.1 -0.2 -0.9 -0.8 -1.7
Smoking Status 0.7 1.6 4.9 1.0 0.2 2.2 -0.2 -1.1 -1.3 -1.6 -1.2
Allergy or Eczema 0.8 2.1 5.5 0.5 0.3 2.4 1.8 1.4 1.4 1.3 1.4
Cardiovascular Disease 0.2 0.7 2.6 -0.2 -0.6 1.6 -0.1 0.1 -1.1 0.4 -0.9
Hypothyroidism (self reported) 2.0 4.6 14.2 -1.2 -0.5 1.0 2.8 2.2 0.9 3.8 -2.5
Respiratory disease 0.7 1.5 4.0 0.4 -0.1 -0.0 -1.7 -1.1 -1.9 -2.0 -0.2
Type 2 Diabetes (T2D) (2018) 0.3 0.6 2.1 -0.1 -0.1 1.3 -0.4 0.5 -0.6 0.1 -1.5
Lung FEV1/FVC ratio 0.5 2.7 8.6 -2.9 -2.3 0.8 0.6 2.4 -0.9 -0.4 -0.1
Lung FVC 0.5 2.7 9.7 -0.4 -0.3 -3.1 -2.8 0.1 -0.5 -1.0 -1.6
Neuroticism 0.3 0.6 1.9 0.7 0.6 -1.4 0.3 -1.0 0.2 0.3 0.9
Chronotype (morning person) 0.7 1.6 3.9 -1.5 -1.4 -2.0 -0.6 1.3 -1.0 1.2 -0.6
Hair Pigment 0.1 3.0 7.3 1.4 1.5 -0.9 -2.5 -1.8 -1.5 -2.7 0.1
Tanning 0.1 1.0 1.9 1.2 1.0 0.2 0.1 -1.4 1.4 -0.3 -1.2
Hand grip strength (left) 0.1 0.2 0.9 0.2 -0.0 -0.0 0.9 -0.1 -0.0 -0.5 -1.0
Number of treatments/medications taken 0.1 0.3 1.0 0.6 0.3 0.1 0.2 -0.7 0.4 1.0 -0.0
Average weekly spirits intake 0.2 0.2 0.8 0.3 0.1 0.3 -0.3 -0.4 -0.5 0.9 -0.6
Sensitivity / hurt feelings 0.7 1.1 4.4 -0.8 -0.7 -0.8 -0.8 0.7 -2.1 -1.0 0.8
Frequency of depressed mood in last 2 weeks 1.0 1.4 3.8 0.8 0.3 -0.5 -2.0 -1.1 -1.9 -1.1 -0.7
Hearing difficulty/problems: Yes 0.5 0.8 2.4 0.9 1.5 -0.6 0.8 0.5 1.1 0.5 -0.5
Relative age of first facial hair 0.2 0.4 1.3 0.6 0.4 -0.9 0.7 0.2 1.2 0.2 -0.6
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 2.9 1.6 1.3 -1.7 0.9 -1.4 0.7 0.4 -1.6
Ever used hormone-replacement therapy (HRT) 0.7 0.9 3.1 0.4 0.5 -1.0 -1.3 -1.8 0.6 0.6 0.5
Ever had hysterectomy (womb removed) 0.8 1.0 4.2 -0.6 -0.3 0.2 0.5 1.2 0.9 2.1 -0.6
Systolic blood pressure, automated reading 0.3 0.9 2.8 1.7 1.3 0.1 -0.5 -0.6 0.6 0.6 -1.3
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.8 -1.2 -1.0 -0.1 -0.9 0.4 -1.4 -0.5 -0.2
Angina 0.8 1.0 2.0 1.2 1.3 1.0 0.1 -1.0 0.7 -0.6 1.4
Medication for hormone replacement therapy 1.0 1.2 2.8 1.7 1.7 0.5 0.5 -1.6 -0.4 -0.6 -0.2
Vitamin and mineral supplements 0.3 0.5 2.0 0.1 0.6 0.2 1.4 1.1 0.3 0.3 -0.2
Supplements: Zinc 0.5 0.5 3.6 -0.2 -0.4 -0.7 0.2 -1.9 -0.0 -0.3 -0.1
Medication: Co-codamol 0.9 1.0 4.6 -0.9 -0.6 -0.3 0.5 1.2 0.1 2.1 -0.7
Medication: Metformin 0.5 0.7 1.4 -0.8 -0.9 0.8 -0.9 0.1 -0.9 -1.2 -0.8
Diabetes (father) 0.4 0.5 1.7 0.2 0.4 1.3 -0.1 0.0 -0.8 -1.1 -0.3
Diabetes (mother) 0.3 0.3 0.7 -0.8 -0.7 0.4 -0.2 0.6 -0.8 0.4 -0.1
Severe depression (siblings) 2.3 2.5 7.6 2.3 2.8 0.7 1.2 -1.4 1.0 -0.7 1.4
Pack years adult smoking proportion 0.3 0.5 1.5 1.2 0.9 0.3 0.9 -0.3 0.4 -0.3 -0.1
Impedance of leg (right) 1.3 6.5 17.4 3.9 4.2 -2.5 1.8 -2.4 2.0 0.4 -0.1
Leg fat-free mass (left) 1.1 5.8 12.1 -2.7 -3.5 1.9 -2.2 -0.3 -3.2 -2.7 1.0
Trunk fat percentage 0.9 3.4 11.2 2.1 1.5 0.5 -1.6 -3.3 -0.6 -2.3 1.1
Hand grip strength (right) 0.2 0.6 3.0 -0.4 -0.9 -0.3 1.7 0.7 0.3 -0.0 -0.6
Townsend deprivation index at recruitment 0.2 0.2 0.8 0.3 0.1 -0.2 0.1 -0.7 -0.6 -0.9 0.2
Current tobacco smoking 0.8 1.3 2.6 -1.1 -1.6 1.0 0.1 1.4 -1.3 -0.5 -1.2
Average weekly fortified wine intake 0.5 0.5 1.2 -1.0 -0.8 -1.0 -0.4 -0.2 -1.1 0.5 0.1
Maternal smoking around birth 0.4 0.6 1.3 1.0 0.9 0.2 0.8 -1.2 0.6 -0.6 -0.4
Fed-up feelings 0.4 0.7 3.8 0.0 -0.6 -0.7 0.4 -0.5 -0.4 0.7 -2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 2.9 -0.8 -1.1 -0.6 0.4 0.9 -0.2 1.7 -0.7
Relative age voice broke 1.2 1.9 5.2 0.0 0.0 -1.6 -1.3 -1.4 -1.2 -2.3 1.6
Taking other prescription medications 0.6 0.9 2.9 0.4 0.3 0.6 1.2 -0.4 -0.9 1.7 -1.2
Age when periods started (menarche) 0.3 0.8 1.7 -0.8 -1.3 -1.1 0.2 -0.0 -0.9 -0.7 -1.2
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 3.7 0.1 0.3 -1.9 -1.0 -0.8 0.3 0.7 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 2.4 5.4 10.8 -3.0 -2.5 -2.0 0.9 3.3 0.5 3.1 -1.7
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 1.8 -0.5 -0.6 1.1 0.5 1.3 -1.1 1.1 -0.1
Qualifications: CSEs or equivalent 1.9 2.6 6.1 2.5 2.4 -0.3 0.9 -1.5 1.2 0.3 -2.0
Serious illness, injury or assault to yourself 1.9 2.3 4.3 1.6 1.3 -0.8 -2.1 -2.0 -1.0 -1.9 -0.8
High blood pressure 0.1 0.4 0.9 -0.6 -0.6 0.5 -0.5 1.0 0.3 0.8 0.1
Hayfever, allergic rhinitis or eczema 0.9 1.9 4.8 0.4 0.2 2.2 1.4 1.4 1.5 1.3 1.4
Multivitamins +/- minerals 0.4 0.5 1.8 -1.1 -1.3 -0.3 -0.3 0.2 0.1 0.9 0.0
Stomach or abdominal pain in last month 1.1 1.3 4.2 1.6 1.5 0.8 0.2 -0.6 2.0 -0.1 -0.9
Supplements: Glucosamine 0.8 1.0 3.2 0.3 -0.2 -0.3 -1.7 -1.8 -0.8 -0.4 0.9
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.7 -1.1 -0.9 -0.6 -0.4 1.1 -1.3 0.3 -0.7
Medication: Atenolol 0.4 0.5 2.2 0.1 -0.1 -0.4 0.0 -0.8 0.7 0.3 1.5
Medication: Levothyroxine sodium 2.2 3.7 15.1 -0.2 0.4 0.7 3.9 1.1 1.1 3.0 -1.5
Sitting height 0.8 5.5 9.6 -1.9 -2.2 -0.3 -2.5 -2.1 -2.6 -3.1 2.8
Chronic bronchitis/emphysema (father) 1.4 1.6 7.1 1.8 1.0 0.0 -1.2 -2.7 -0.3 -0.4 -0.0
High blood pressure (mother) 1.0 1.4 3.0 1.3 1.4 -0.1 -1.2 -1.4 -0.8 -1.7 0.7
Body mass index (BMI) 0.1 0.3 2.0 0.5 0.1 1.4 -0.3 -0.5 -0.0 -0.3 0.2
Impedance of leg (left) 1.5 7.3 20.2 4.3 4.5 -2.4 1.2 -2.9 2.1 0.2 -0.0
Leg predicted mass (left) 1.1 5.9 12.2 -2.8 -3.5 1.9 -2.2 -0.4 -3.2 -2.7 1.0
Trunk fat mass 0.6 2.5 7.1 0.8 0.1 0.7 -1.8 -2.7 -1.4 -2.3 1.2
Waist circumference 0.2 0.6 1.8 -0.0 -0.7 1.3 -0.9 -0.4 -0.9 -0.6 0.2
Number of incorrect matches in round 1.6 2.7 7.5 2.0 1.6 -0.3 -0.6 -2.4 -1.0 -2.7 -0.1
Past tobacco smoking 1.3 2.4 10.4 -1.7 -0.8 -3.2 -0.5 1.4 1.0 0.9 1.2
Alcohol usually taken with meals 0.7 1.1 2.4 1.4 1.6 -0.4 0.7 -0.8 1.1 -0.0 1.3
Nervous feelings 1.7 3.1 8.4 -2.0 -1.5 -2.9 0.6 2.8 -1.0 1.1 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.6 -0.1 -0.6 -1.3 -0.3 -0.3 -0.3 0.7 -0.8
Hearing difficulty/problems with background noise 0.8 1.4 2.6 1.3 1.5 1.6 0.6 0.2 1.1 0.5 -1.5
Hair/balding pattern: Pattern 2 0.6 0.8 3.1 -1.2 -0.9 -1.8 -0.4 0.6 -0.1 -0.5 -0.6
Had menopause 0.6 0.8 1.6 -1.2 -1.2 -0.5 -0.6 0.3 -0.4 1.0 1.2
Had other major operations 0.6 0.7 2.7 -0.0 -0.1 -1.3 0.2 0.4 0.6 1.7 0.5
Forced vital capacity (FVC) 1.6 6.0 13.5 -1.4 -1.8 -2.6 -3.7 -1.1 -3.0 -3.5 0.1
Heel bone mineral density (BMD) T-score, automated (right) 2.8 6.4 14.4 -3.3 -3.0 -0.8 0.4 3.8 0.4 3.2 -2.3
Ever unenthusiastic/disinterested for a whole week 1.5 1.8 4.4 1.6 1.4 0.1 2.1 -1.5 1.5 0.6 0.9
Qualifications: None of the above 0.9 2.0 4.7 -1.6 -1.9 0.2 0.4 2.1 0.5 2.2 -0.5
Financial difficulties in last 2 years 1.7 2.3 6.9 2.6 2.0 0.5 1.5 -1.9 1.0 -0.5 -0.1
Mouth/teeth dental problems 0.5 0.8 1.9 -1.4 -0.8 0.8 -0.8 1.2 -0.9 -0.4 -0.0
Heart attack 0.2 0.2 0.7 0.1 0.4 0.5 -0.4 -0.9 0.0 -0.2 0.5
Allergy 0.5 1.1 2.5 0.1 0.4 -1.3 -0.9 -1.5 -1.2 -1.6 -0.5
Pain all over the body in last month 3.0 3.2 8.9 1.1 1.3 0.3 3.0 0.8 2.2 2.9 -0.2
Diabetes (self-reported) 0.5 0.8 1.4 -0.9 -0.5 1.2 -0.4 1.0 -1.1 -0.7 -1.0
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 3.6 -0.3 -0.6 0.6 1.4 1.6 1.9 1.7 0.3
Medication: Ramipril 1.1 1.4 4.4 1.0 0.9 0.0 0.3 -0.7 1.8 1.0 2.1
Medication: Simvastatin 0.7 1.0 2.5 -0.3 -0.2 0.4 1.0 1.3 -0.5 1.6 -1.4
Fluid intelligence score 0.6 1.3 3.0 1.5 1.7 1.6 -0.2 -1.3 0.6 -0.6 -0.7
Illnesses of siblings 0.5 0.7 2.5 -0.6 -0.7 -1.6 0.2 0.4 -0.7 -0.1 -1.3
Neuroticism score 0.3 0.7 4.5 0.0 -0.1 -2.1 0.2 -0.1 -0.7 0.7 -0.4
Weight 0.5 2.7 4.8 -1.3 -2.0 1.1 -1.9 -1.0 -2.2 -2.0 1.1
Impedance of arm (right) 0.6 2.9 6.2 1.9 1.7 -1.8 -1.1 -2.4 -0.3 -2.5 0.4
Arm fat percentage (right) 0.4 1.5 3.7 1.4 0.8 1.1 -1.1 -1.9 -0.4 -1.6 0.5
Trunk fat-free mass 0.9 5.1 16.2 -3.5 -4.0 1.2 -1.3 0.9 -2.7 -1.1 0.5
Hip circumference 0.4 1.8 4.1 0.4 -0.3 2.0 -1.3 -1.7 -1.4 -1.7 0.5
Time employed in main current job 0.3 0.4 1.1 -0.3 -0.5 -0.5 -0.6 -0.9 0.2 -0.3 -1.1
Alcohol intake versus 10 years previously 0.6 0.9 4.4 0.9 0.8 0.6 2.1 0.2 0.6 0.3 -0.7
Father’s age at death 0.3 0.4 1.3 0.3 0.3 -0.5 -1.2 -0.2 -1.1 -0.5 -0.2
Worrier / anxious feelings 0.9 1.6 7.6 -0.7 -0.5 -2.8 -0.3 1.1 -0.9 0.9 -1.2
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 2.5 -0.3 -0.9 -1.3 -0.3 -0.4 0.1 0.2 -1.6
Falls in the last year 0.7 1.0 2.7 0.5 0.4 -0.1 -0.4 -1.2 -1.6 -1.0 1.4
Hair/balding pattern: Pattern 3 0.6 0.9 3.0 -0.5 -0.7 -0.8 0.6 0.2 1.7 1.0 1.2
Number of live births 2.7 3.8 7.8 2.4 2.7 1.3 2.8 0.4 1.6 1.6 -1.7
Forced expiratory volume in 1-second (FEV1) 1.5 4.9 10.2 -1.9 -2.0 -2.5 -3.2 -0.3 -2.2 -3.2 -0.3
Pulse rate 0.2 0.3 1.1 -0.3 0.1 -0.8 0.0 1.0 0.1 0.4 0.5
Happiness 1.1 1.3 7.5 0.4 0.6 0.5 2.7 0.8 0.3 0.5 -1.2
Noisy workplace 0.9 1.1 2.5 1.4 1.1 -0.1 -1.0 -1.6 0.3 -0.4 1.4
Qualifications: A levels/AS levels or equivalent 0.7 1.5 2.9 -1.5 -1.4 -0.9 0.5 1.6 -0.7 -0.7 -1.7
Serious illness, injury or assault of a close relative in last 2 years 2.1 2.4 6.0 -2.2 -1.8 -0.8 0.1 2.4 -1.6 0.9 -1.1
Mouth/teeth dental problems: Dentures 0.3 0.5 1.1 -0.7 -0.5 1.0 0.7 0.9 0.6 0.8 0.2
Asthma 0.3 0.5 1.3 0.7 0.2 -0.2 -1.1 -1.1 -0.5 -1.0 -0.2
Medication: Ibuprofen (e.g. Nurofen) 2.2 2.8 14.1 0.7 1.2 -1.1 0.4 -1.6 0.7 -1.5 3.8
Medication: Cholesterol lowering 1.0 1.6 3.0 1.7 1.7 1.2 1.6 -0.6 0.9 1.3 0.3
Depression (self-reported) 0.6 0.7 3.9 0.7 0.1 1.1 0.3 -0.1 0.1 0.3 -2.0
Medication: Lansoprazole 0.9 1.1 2.8 1.5 1.2 -0.6 -0.6 -1.7 -0.1 -0.9 0.4
Prospective memory result 1.7 2.1 6.1 -2.0 -1.8 0.4 0.4 2.5 -0.1 1.6 0.5
Lung cancer (father) 0.7 0.8 2.1 -1.0 -1.5 1.3 -0.5 1.0 -0.2 0.6 0.6
Illnesses of mother 1.2 1.5 3.2 -1.3 -1.0 -0.3 1.3 1.4 0.2 1.5 -1.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.4 10.0 -1.1 -1.3 -2.5 -2.0 -0.4 -1.7 -3.2 -1.0
Pulse wave Arterial Stiffness index 0.3 0.4 0.9 0.9 0.6 0.0 -0.3 -0.4 -0.7 -0.2 -1.0
Impedance of arm (left) 0.9 4.0 9.1 1.8 1.7 -2.4 -1.4 -2.8 -0.9 -3.0 0.6
Arm fat mass (right) 0.3 1.3 2.8 0.4 -0.3 1.3 -1.4 -1.5 -0.9 -1.7 0.7
Trunk predicted mass 0.9 4.9 15.7 -3.4 -4.0 1.2 -1.2 0.9 -2.6 -1.0 0.5
Standing height 1.1 11.2 22.9 -3.9 -4.6 -0.4 -3.1 -1.1 -4.8 -3.9 2.2
Length of working week for main job 0.7 0.8 1.5 1.2 1.0 -0.7 0.2 -1.2 0.1 -1.1 0.9
Exposure to tobacco smoke at home 1.8 2.0 4.2 -1.0 -1.3 0.9 1.3 2.0 0.4 1.7 -1.9
Breastfed as a baby 1.6 1.9 5.9 -2.1 -2.4 -0.0 -1.0 1.1 -0.2 0.7 1.5
Tense / ‘highly strung’ 0.4 0.7 2.7 0.5 0.2 -1.4 -0.4 -0.6 -0.2 -0.1 -1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 3.5 1.9 1.5 0.8 0.4 -1.7 -0.8 -0.9 -1.2
Hair/balding pattern: Pattern 4 0.8 1.9 5.2 -0.2 -0.3 2.3 -0.7 1.7 -1.6 -0.4 -1.8
Birth weight of first child 0.7 1.3 4.4 -0.7 -0.6 0.7 1.7 0.9 0.9 2.1 0.3
Peak expiratory flow (PEF) 0.9 2.1 6.4 -1.9 -1.9 -2.5 -1.3 0.6 -0.1 -0.6 -0.9
Pulse wave reflection index 0.4 0.4 1.7 0.4 0.1 0.3 -0.3 -1.0 -0.5 -1.3 -0.4
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.5 0.2 -0.4 -0.2 -1.2 -1.2 -0.5 -1.1 1.1
Loud music exposure frequency 0.2 0.2 0.6 -0.2 0.2 -0.2 -0.8 -0.0 0.5 -0.4 0.6
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 2.5 -0.4 -0.3 -1.6 -0.2 -0.4 -0.6 -1.2 0.6
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 4.6 0.8 0.3 -2.1 -0.5 -1.2 -1.5 -1.2 -0.5
Blood clot in the leg (DVT) 0.6 0.8 2.7 -0.3 -0.1 -0.0 1.0 1.7 0.7 1.2 -0.9
Medication: Paracetamol 0.4 0.6 2.4 0.4 0.1 1.1 -0.2 -0.1 0.7 0.9 -1.5
Headache pain in last month 0.5 0.8 1.6 -0.9 -0.9 1.2 0.1 1.3 -0.8 0.6 -0.7
Medication for cholesterol, blood pressure or diabetes 0.2 0.2 0.8 -0.6 -0.5 -0.5 -0.2 0.5 0.0 -0.9 -0.3
Glaucoma (self-reported) 0.6 0.7 2.9 -0.7 -0.9 1.7 -0.4 -0.1 -0.8 0.3 -0.6
Gout (self-reported) 1.2 1.6 3.4 -0.5 -0.8 0.3 -1.8 -0.8 -1.5 -1.7 1.6
Hypothyroidism/myxoedema (self-reported) 3.0 5.9 16.1 -1.2 -0.5 0.7 4.0 2.5 0.5 4.0 -2.6
Medication: Amlodipine 0.2 0.2 1.2 -0.2 -0.2 -0.3 -0.6 -0.1 0.0 0.1 1.1
Medication: Ventolin 100micrograms inhaler 1.1 1.4 3.9 1.1 0.9 0.2 1.5 -1.1 1.2 -0.4 2.0
Birth weight 1.2 2.7 8.9 -2.5 -3.0 1.4 -0.4 1.4 -1.4 0.3 -0.1
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.4 -0.4 -0.7 0.4 0.1 0.4 1.2 0.9 0.6
High blood pressure (siblings) 0.5 0.8 3.9 0.0 0.0 2.0 0.1 0.6 0.3 -0.2 1.3
Forced vital capacity (FVC), Best measure 1.2 4.4 12.3 -0.9 -1.2 -2.9 -2.5 -1.1 -2.2 -3.5 -0.2
Body fat percentage 0.6 2.5 7.7 2.3 1.7 0.7 -0.9 -2.8 0.0 -1.5 0.6
Leg fat percentage (right) 0.5 1.7 5.6 2.4 1.9 0.6 0.6 -1.6 1.0 0.2 0.1
Arm fat-free mass (right) 0.6 3.2 8.5 -2.4 -2.9 1.5 -1.3 0.0 -2.4 -1.2 0.4
Exposure to tobacco smoke outside home 0.7 0.9 3.2 -0.5 -0.7 -0.6 1.1 1.1 0.5 1.8 -0.2
Comparative body size at age 10 0.3 0.8 1.6 -0.9 -0.6 1.0 0.8 1.3 -0.2 0.9 -1.2
Number of full brothers 1.6 2.0 5.8 -1.7 -1.6 0.2 -0.1 2.4 -0.1 1.8 -1.1
Worry too long after embarrassment 0.5 0.8 4.4 0.2 0.6 -2.1 -0.2 -0.4 0.9 -0.2 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.0 0.7 0.4 -0.0 0.3 -1.0 -0.7 -0.7 -0.8
Wheeze or whistling in the chest in last year 0.2 0.3 1.2 0.9 0.2 0.2 0.0 -1.1 0.2 -0.4 0.6
Number of children fathered 0.4 0.5 2.3 0.4 0.6 -0.5 0.5 0.2 -0.6 0.4 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.5 2.5 1.6 1.5 -0.7 0.7 -1.1 1.6 1.2 0.8
Age at first live birth 0.4 0.7 2.6 -0.2 -0.2 -0.6 -1.6 -0.2 -0.7 -1.2 -0.7
Pulse wave peak to peak time 0.5 0.5 1.8 -1.3 -1.1 -0.3 -0.0 0.5 0.3 0.1 1.0
Health satisfaction 0.9 1.1 3.5 -1.6 -1.9 -0.2 0.9 1.1 -0.5 0.3 0.6
Shortness of breath walking on level ground 0.9 1.1 3.5 -0.7 -0.4 1.2 1.4 0.7 0.6 0.6 1.9
Qualifications: College or University degree 0.7 2.3 4.6 -1.9 -1.2 1.8 -1.1 0.2 -0.7 -2.1 1.9
Eye problems/disorders: None of the above 0.2 0.3 0.7 0.3 0.2 0.1 0.8 0.5 0.5 -0.0 0.9
Mouth/teeth dental problems: Loose teeth 0.6 0.8 1.8 1.2 1.1 0.6 1.3 0.3 0.9 0.6 -0.3
Emphysema/chronic bronchitis 1.4 1.6 4.0 -1.8 -1.7 -0.5 0.1 2.0 -0.7 1.2 -0.5
Medication for pain relief, constipation, heartburn 0.3 0.6 1.6 0.4 0.3 -0.3 -0.0 -0.4 -1.2 -1.2 -1.0
Neck or shoulder pain in last month 0.6 0.8 1.6 1.1 0.7 0.4 -0.9 -1.3 -0.6 -0.4 -1.2
Medication: Blood pressure 0.1 0.2 0.8 -0.3 -0.4 0.9 -0.1 0.3 -0.0 0.6 0.7
Angina (self-reported) 0.8 1.1 2.1 1.2 1.3 1.1 0.4 -0.8 1.0 -0.3 1.5
Migraine (self-reported) 0.7 0.8 1.4 -1.0 -0.8 -1.0 0.6 1.2 -1.2 -0.7 0.6
Medication: Ibuprofen 2.1 2.6 10.3 0.5 0.7 -2.1 0.3 -1.6 1.3 -0.9 3.2
Medication: Allopurinol 0.4 0.5 2.2 0.3 0.2 -0.9 -0.1 -0.9 0.0 -0.7 1.5
Medication: Omeprazole 1.8 2.2 4.4 1.7 1.6 0.5 1.3 -0.9 2.1 2.0 -0.9
Medication: Seretide 50 evohaler 0.4 0.5 1.3 0.7 0.2 0.6 -0.5 -1.1 0.3 -0.9 0.9
Mean time to correctly identify matches 1.1 2.1 6.9 -1.5 -1.5 -0.6 -0.7 1.6 -2.6 -0.2 -1.5
Heart disease (mother) 1.1 1.4 3.6 1.4 1.4 0.3 -0.9 -1.9 0.4 -0.8 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.5 0.9 0.6 -0.6 -0.6 -1.2 1.1 -0.7 0.2
Whole body fat mass 0.4 1.7 4.4 0.8 0.1 1.1 -1.3 -2.1 -1.0 -1.9 0.8
Leg fat mass (right) 0.3 1.0 3.1 0.9 0.3 1.1 -0.7 -1.8 -0.6 -1.3 0.6
Arm predicted mass (right) 0.7 3.3 8.3 -2.5 -2.9 1.5 -1.4 0.1 -2.5 -1.2 0.6
Pulse rate, automated reading 0.4 1.3 3.0 -1.7 -1.7 -1.2 -0.6 0.8 -1.4 -0.6 -0.6
Alcohol intake frequency. 0.2 0.4 1.0 -1.0 -1.0 -0.2 -0.3 -0.3 -0.2 -0.3 0.9
Comparative height size at age 10 1.0 5.7 15.5 -3.5 -3.9 0.8 -1.3 1.1 -3.6 -1.1 -0.1
Number of full sisters 0.5 0.6 2.9 0.5 0.7 -0.6 -0.5 -0.1 0.1 -0.6 -1.7
Suffer from ‘nerves’ 0.9 1.5 6.7 -1.4 -1.2 -2.6 -0.6 0.3 -1.1 0.0 0.2
Overall health rating 0.5 1.0 5.7 -0.2 -0.6 0.2 0.6 0.7 -0.9 0.2 -2.4
Chest pain or discomfort 0.1 0.2 0.4 -0.2 0.0 -0.5 0.4 0.6 -0.1 -0.3 -0.5
Had major operations 1.7 2.0 6.6 0.9 0.9 -0.7 -0.4 -2.6 -1.2 -2.1 1.1
Age at last live birth 0.3 0.4 1.1 -0.6 -0.3 0.4 -0.9 0.4 -1.1 -0.6 -0.5
Family relationship satisfaction 1.6 1.9 6.9 1.4 1.5 2.6 1.4 -1.1 0.3 -1.0 -0.1
Leg pain on walking 0.6 0.7 2.1 0.1 0.1 -1.5 -1.4 -1.0 -0.3 -0.7 0.1
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.6 4.6 1.9 2.1 -1.3 0.3 -1.6 0.7 0.1 0.4
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.1 1.4 1.5 1.3 -0.3 -0.4 -0.4 1.0 -0.1
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.9 -0.1 0.1 0.9 -0.1 -0.6 0.8 -0.2 0.7
Medication: Aspirin 0.4 0.5 2.1 -0.8 -0.6 0.6 -0.4 0.7 -0.0 1.5 0.0
Supplements: Vitamin C 0.3 0.3 1.2 0.4 0.4 0.1 -0.8 -1.1 -0.1 0.1 -0.5
Knee pain experienced in last month 0.8 1.3 4.0 -0.2 -0.8 -1.0 -2.0 -0.9 -1.1 -0.9 -1.4
Hypertension (Self-reported) 0.2 0.6 1.6 -1.1 -1.0 0.4 -0.6 1.3 0.0 0.9 0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 3.7 1.5 1.7 -0.3 -1.1 -1.9 -0.1 -0.8 0.9
Illnesses of father: Heart disease 2.1 2.9 6.4 1.3 1.4 -0.5 -2.3 -2.1 -1.5 -2.5 1.2
Illnesses of siblings: Diabetes 1.0 1.2 3.1 -1.8 -1.4 0.9 0.3 1.5 -0.0 1.2 -0.1
Smoking status: Previous 1.9 2.8 11.2 2.0 1.3 3.3 0.4 -1.9 -0.8 -1.1 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 3.4 -0.4 -0.8 0.2 -0.3 -1.1 -1.8 -1.4 0.6
Whole body fat-free mass 1.0 5.7 15.1 -3.2 -3.9 1.7 -1.8 0.3 -3.1 -1.8 0.8
Leg fat-free mass (right) 1.2 6.6 13.2 -2.9 -3.6 2.0 -2.6 -0.3 -3.4 -2.8 1.0
Arm fat percentage (left) 0.5 1.9 5.0 1.5 0.9 0.7 -1.4 -2.2 -0.6 -2.0 0.2
Average weekly red wine intake 0.5 0.7 1.8 1.0 1.3 0.5 0.7 -0.9 -0.8 -0.5 0.4
Handedness (chirality/laterality): Left-handed 0.6 0.8 1.9 -1.4 -0.7 -1.0 -1.0 1.2 -0.5 -0.1 0.1
Mood swings 1.2 2.1 4.5 1.4 1.1 -1.4 -0.4 -2.1 -1.6 -1.7 -1.2
Loneliness, isolation 0.6 0.8 2.1 1.3 1.0 1.1 0.5 -1.5 -0.3 -0.4 0.5
Long-standing illness, disability or infirmity 0.9 1.4 3.7 -0.5 -0.8 -1.1 -1.5 -0.8 -1.9 -1.5 -0.8
Ever had bowel cancer screening 0.5 0.6 2.5 -0.3 -0.1 -0.1 -1.6 0.4 -1.1 -0.2 -0.6
Diabetes diagnosed by doctor 0.5 0.8 3.2 -0.3 -0.1 1.8 0.1 0.6 -0.8 -0.5 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 2.5 1.6 1.3 1.0 0.7 0.0 1.4 1.1 -1.1
Friendships satisfaction 2.0 2.5 7.1 2.1 2.7 1.1 2.2 0.1 1.3 0.4 -0.8
Qualifications: nursing, teaching 0.5 0.9 2.2 -1.5 -1.5 0.3 -0.2 0.6 -0.9 -0.0 -1.1
Commuting to job workplace: Walk 0.3 0.3 1.4 0.2 -0.0 -0.2 -0.2 -0.7 -0.3 -1.2 0.6
Eye problems/disorders: Cataract 0.2 0.2 0.8 0.3 0.5 -0.7 -0.4 -0.3 0.3 0.4 -0.9
Mouth/teeth dental problems: Mouth ulcers 1.2 2.0 5.4 2.2 1.4 -1.0 0.7 -2.3 1.3 0.8 0.1
Medication for cholesterol 0.1 0.2 0.5 0.4 0.2 0.5 0.3 0.3 -0.7 0.2 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.8 -0.3 0.0 0.9 0.4 0.4 -0.2 -0.1 0.7
Back pain experienced in last month 0.6 0.9 2.6 -0.6 -1.0 -1.1 -0.9 -0.4 0.8 1.6 -1.0
Mineral and other dietary supplements 1.1 1.5 7.1 1.0 1.3 0.3 2.7 1.0 1.0 0.0 0.0
Breast cancer (self-reported) 1.5 1.8 6.8 0.0 0.1 0.1 2.6 2.0 1.4 1.0 0.4
Asthma (self-reported) 0.3 0.6 1.7 0.8 0.4 -0.3 -1.0 -1.3 -0.5 -1.1 -0.1
Osteoporosis (self-reported) 0.9 1.1 2.3 1.2 1.5 -1.4 0.6 -0.2 1.1 1.0 0.7
Osteoarthritis (self-reported) 0.4 0.6 0.8 -0.7 -0.9 0.9 -0.3 0.8 -0.6 0.9 -0.8
Medication: Aspirin 0.6 0.8 3.3 -1.0 -0.7 0.3 -0.1 1.1 0.4 1.8 0.1
Medication: Gliclazide 0.2 0.2 0.6 -0.6 -0.3 0.4 0.4 0.6 -0.5 0.2 -0.8
Illnesses of father: None of the above (group 1) 1.6 2.0 4.4 -1.8 -1.9 0.5 1.5 2.1 -0.3 1.3 -0.5
Smoking status: Current 0.6 1.0 2.0 -0.9 -1.3 0.7 0.3 1.1 -1.2 -0.6 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.8 9.0 -1.1 -0.9 -3.0 -1.3 0.5 -0.1 -0.4 -1.0
Whole body water mass 1.0 6.0 15.9 -3.3 -4.0 1.8 -1.8 0.4 -3.2 -1.8 0.8
Leg predicted mass (right) 1.2 6.6 13.4 -2.9 -3.7 2.1 -2.6 -0.2 -3.4 -2.8 1.0
Arm fat mass (left) 0.4 1.5 3.8 0.5 -0.2 1.0 -1.4 -1.8 -1.1 -1.9 0.7
Number of self-reported non-cancer illnesses 0.2 0.4 1.7 0.7 0.5 -0.2 0.1 -0.6 -0.5 1.3 -0.2
Average weekly champagne plus white wine intake 0.8 1.1 2.6 1.1 1.1 1.6 0.6 -0.3 1.1 -1.4 0.3
Miserableness 0.6 1.1 2.3 1.5 1.4 0.3 0.1 -1.3 -0.5 -1.4 -0.9
Guilty feelings 0.3 0.4 1.0 0.1 -0.0 -1.0 -0.7 -0.3 -0.8 1.0 -0.2
Wears glasses or contact lenses 1.6 1.8 8.0 -1.1 -0.9 1.1 0.7 0.7 0.0 1.5 2.8
Ever taken oral contraceptive pill 0.6 0.7 3.8 0.3 -0.0 2.0 0.2 -0.6 -1.0 -0.3 0.1
Hearing aid user 1.4 1.6 3.3 -1.8 -1.5 -0.7 0.7 1.4 1.0 1.8 0.5
Mother’s age at death 0.8 1.0 2.7 -0.7 -1.4 0.3 -1.6 0.2 -0.9 -1.1 1.0
Financial situation satisfaction 2.8 3.5 13.8 2.2 2.2 1.1 3.7 -0.3 1.6 0.4 -0.6
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.5 -0.3 -0.7 1.2 0.3 0.6 0.2 0.1 0.1
Commuting to job workplace: Public transport 3.1 3.7 12.2 -3.5 -3.5 -0.3 -1.0 1.9 -0.5 -0.2 0.5
Eye problems/disorders: Glaucoma 1.3 1.5 4.3 -1.3 -1.5 2.1 0.2 1.1 0.0 1.4 -1.0
Medication: Blood pressure 0.3 0.6 1.9 -1.0 -0.9 -1.4 -0.6 0.2 0.9 0.4 0.4
Pain type(s) experienced in last month: Hip pain 0.9 1.2 6.1 0.7 0.4 -2.5 -0.8 -1.3 0.3 -0.3 -0.0
Supplements: Fish oil (including cod liver oil) 0.9 1.1 3.1 -1.2 -1.5 0.1 -1.8 0.3 -1.2 0.2 -0.8
High cholesterol (Self-reported) 0.4 0.8 1.8 1.2 0.5 1.1 0.7 -0.8 -0.1 0.3 -1.3
Medication: Bendroflumethiazide 0.8 1.2 3.2 -1.8 -1.8 -0.7 -0.4 1.5 -0.0 0.5 0.2
Medication: Paracetamol 0.5 0.7 2.3 -0.1 -0.3 -0.0 0.1 0.6 0.9 1.4 -1.5
Medication: Lisinopril 1.4 1.8 8.9 -0.5 -1.0 3.0 -0.2 -0.0 -1.2 -1.2 1.2
Medication: Atorvastatin 0.5 0.6 2.0 -0.1 -0.5 1.3 0.5 0.1 0.9 -0.4 1.4
Illnesses of father: High blood pressure 0.6 0.7 2.6 -1.2 -0.9 -0.6 -0.1 1.6 -0.6 0.3 0.2
Alcohol drinker status: Never 0.9 1.0 3.0 -0.2 0.7 0.5 1.7 1.0 1.5 1.1 -0.2
Ever smoked 0.9 1.6 4.7 1.4 0.5 1.9 -0.0 -0.9 -0.7 -0.8 -2.2
Basal metabolic rate 0.8 4.7 11.0 -2.6 -3.3 1.7 -1.9 -0.1 -2.8 -2.0 0.9
Leg fat percentage (left) 0.6 2.1 6.8 2.6 2.1 0.7 0.3 -1.9 1.1 -0.0 0.3
Arm fat-free mass (left) 0.5 2.6 7.3 -2.1 -2.7 2.0 -0.9 0.2 -1.8 -0.7 0.6
Number of operations (self-reported) 1.1 1.6 5.0 1.6 1.5 0.0 2.2 -0.7 -0.4 1.7 -0.2
Average weekly beer plus cider intake 0.8 1.2 3.9 -0.2 -0.4 0.2 -1.4 -0.4 -2.0 -1.8 -0.1
Irritability 0.3 0.6 2.7 0.8 0.2 -0.5 0.1 -0.8 -0.4 0.5 -1.6
Risk taking 1.0 1.5 3.5 1.3 1.4 1.2 -0.1 -1.8 -0.1 -1.9 0.2
Ever had prostate specific antigen (PSA) test 1.2 1.4 3.3 -1.0 -1.1 -1.5 -0.4 1.5 -1.1 0.4 -1.8
Fractured/broken bones in last 5 years 0.8 1.1 5.7 -0.8 -0.7 0.7 -0.5 0.6 -2.4 -0.5 -0.5
Age started oral contraceptive pill 0.4 0.5 2.2 -0.4 -0.4 0.2 -0.3 -0.3 -0.4 -0.9 1.5
Diastolic blood pressure, automated reading 0.2 0.6 2.0 0.7 0.6 0.5 0.7 0.4 0.9 1.4 -0.8
Ever depressed for a whole week 1.3 1.6 5.7 0.6 0.7 0.9 2.4 0.9 1.7 1.5 -0.2
Unable to work because of sickness or disability 0.2 0.3 0.9 0.4 0.2 0.6 0.9 -0.2 -0.2 0.3 -0.6
Commuting to job workplace: Cycle 0.2 0.2 1.3 -0.4 -0.1 -0.0 0.3 0.1 -0.2 -1.1 -0.1
Myopia 0.1 0.1 0.4 0.1 -0.3 0.4 0.2 -0.1 -0.6 -0.1 0.3
Vascular/heart problems diagnosed by doctor 0.1 0.3 1.2 0.5 0.4 -0.4 0.1 -0.7 -0.4 -1.1 -0.0
Cholesterol lowering medication 0.7 1.0 2.3 -0.9 -1.2 1.5 0.4 1.2 0.3 0.8 -1.1
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 2.7 0.9 0.9 -0.4 0.4 -0.7 1.6 0.7 0.2
Pain experienced in last month 0.5 0.9 3.1 -0.1 0.3 0.0 1.6 0.4 0.8 -0.5 1.8
Supplements: Calcium 0.3 0.3 0.9 -0.4 0.1 0.3 0.8 0.3 0.7 1.0 -0.0
Basal cell carcinoma (self-reported) 0.9 1.0 1.9 -1.1 -1.4 -0.0 0.8 1.2 -1.4 -0.0 -1.1
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.9 0.1 0.4 0.4 -0.4 -1.0 0.1 -0.1 0.5
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 3.2 -0.3 -0.1 -0.0 1.4 1.8 1.0 1.8 -0.9
Heart disease (siblings) 1.5 1.9 5.4 2.3 2.3 1.1 0.6 -1.6 0.6 -0.2 0.2
Alcohol drinker status: Previous 0.3 0.3 1.4 -0.0 0.1 0.1 0.2 -0.0 0.7 0.5 1.2
Pack years of smoking 0.2 0.3 0.9 0.9 0.6 0.2 0.9 -0.0 0.5 0.1 -0.1
Impedance of whole body 1.1 5.6 12.6 3.5 3.5 -2.3 -0.0 -3.2 1.0 -1.7 0.7
Leg fat mass (left) 0.3 1.2 3.7 1.1 0.5 1.2 -0.7 -1.9 -0.4 -1.4 0.6
Arm predicted mass (left) 0.6 3.1 8.8 -2.5 -3.0 2.2 -0.9 0.5 -1.6 -0.8 1.0