Hub : Genes

RTN2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.1240	0.0409	4.7e-04	0.021	NA	0.050	NA	0.021	3.5e-03	NA	1.1e-05	NA	3.1e-03
2	GTEx	Skin Sun Exposed Lower leg	0.2110	0.0540	7.7e-06	0.056	NA	0.099	NA	0.103	2.1e-05	NA	1.5e-08	NA	6.8e-09
3	YFS	Blood	0.0332	0.0123	4.8e-04	0.025	0.014	0.022	0.026	0.024	7.1e-09	1.4e-05	9.5e-08	6.5e-09	2.4e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.1	0.1	-0.4	-0.2	-0.3
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	-0.0	-0.6	-0.0
Depressed Affect (Nagel 2018)	0.9	1.9	2.7	1.2	1.6	1.3
Depression (Nagel 2018)	0.9	1.3	2.5	1.6	0.9	0.8
Intelligence (Savage-Jansen 2018)	0.5	1.7	2.9	-0.3	-1.7	-1.4
Neuroticism (Nagel 2018)	0.7	1.6	2.2	1.5	0.9	1.3
Schizophrenia (2018)	0.1	0.2	0.5	0.3	-0.7	0.3
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	1.0	0.0	0.3
Worry (Nagel 2018)	0.2	0.4	1.0	1.0	-0.3	0.2
Alzheimer’s Disease (in mother)	0.9	1.0	1.6	0.8	-0.9	1.3
Alzheimer’s Disease (in father)	1.3	1.4	2.7	-1.2	-1.6	-0.1
Alzheimer’s Disease (including proxy)	1.4	2.0	4.7	1.1	-2.2	0.5
Crohns Disease (2017)	2.7	5.9	8.0	-2.8	-2.2	2.3
Irritable Bowel Disease (IBD)	0.6	1.4	2.3	-1.0	-0.9	1.5
Ulcerative Colitis (UC)	0.6	1.1	2.2	1.5	1.0	0.3
Major Depression (MDD)	1.0	1.2	2.3	-1.5	-1.0	0.6
Reaction Time	1.7	3.3	4.8	-2.2	-1.6	-1.6
Verbal and Numeric Reasoning (VNR)	0.5	1.1	1.7	-0.3	-1.3	-1.3
Breast Cancer	0.5	1.2	2.9	0.2	-0.8	1.7
Ovarian Cancer	1.4	1.9	3.2	-1.1	-1.8	-1.0
Prostate Cancer	0.2	0.2	0.5	0.5	0.7	-0.0
Age at First Birth	1.3	1.8	5.1	2.2	0.4	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.8	2.5	3.8	-1.9	-2.0	-0.3
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	1.3	2.0	3.0	-1.5	-0.9	1.7
Mean Putamen Volume	0.8	0.9	2.1	1.5	0.7	0.4
Fasting Glucose	0.9	1.0	2.1	-1.5	-0.8	0.7
HbA1C	0.1	0.1	0.3	-0.5	-0.2	0.1
HDL Cholesterol	1.0	1.6	2.4	0.8	-1.6	1.3
LDL Cholesterol	3.1	4.9	13.1	-1.2	-0.6	3.6
Lupus	0.1	0.2	0.5	-0.7	-0.3	0.1
Neuroticism (2016)	0.7	1.1	2.6	1.6	0.7	-0.4
Primary Biliary Cirrhosis	0.9	1.2	3.0	0.8	1.7	0.3
Rheumatoid Arthritis	0.1	0.1	0.2	0.4	-0.2	0.0
Schizophrenia (2014)	0.0	0.0	0.0	0.1	-0.1	-0.1
Triglycerides	0.6	0.9	2.1	0.8	0.2	-1.4
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	1.0	1.5	2.3	1.5	1.3	0.6
Blood Eosinophil Count	1.0	7.6	22.7	4.8	-0.3	0.0
Blood Platelet Count	3.6	41.7	104.0	10.2	3.8	2.6
Blood Red Count	0.6	5.7	13.5	-3.7	0.3	1.8
Blood White Count	1.3	9.6	21.6	4.7	0.9	2.5
Heel T-Score	2.0	15.7	31.9	-2.2	-5.7	3.2
BMI	0.2	1.1	3.0	-1.7	-0.0	-0.4
Height	0.0	0.0	0.0	0.0	0.1	0.0
Waist Hip Ratio (WHR)	2.1	9.4	15.1	-3.9	-3.6	0.5
Systolic Blood Pressure	1.4	7.2	10.7	-3.3	-2.4	2.3
Smoking Status	0.3	0.7	1.5	-0.7	1.2	-0.1
Allergy or Eczema	1.2	3.1	9.2	0.2	0.0	-3.0
Cardiovascular Disease	2.3	7.5	12.0	-3.5	-3.2	0.6
Hypothyroidism (self reported)	0.4	1.0	2.2	-1.5	-0.7	0.5
Respiratory disease	1.1	2.4	7.1	0.2	0.1	-2.7
Type 2 Diabetes (T2D) (2018)	3.0	5.6	9.5	-3.1	-2.7	0.1
Lung FEV1/FVC ratio	2.2	11.2	17.8	-3.3	-4.2	2.2
Lung FVC	1.1	5.5	9.1	2.6	3.0	0.8
Neuroticism	0.6	1.6	3.0	1.7	1.2	0.5
Chronotype (morning person)	1.3	3.1	3.5	1.8	1.9	-1.6
Hair Pigment	0.2	4.4	5.2	2.0	2.3	-2.1
Tanning	0.1	1.6	3.0	1.2	1.7	0.5
Hand grip strength (left)	0.5	1.4	2.3	-0.1	-1.3	1.5
Number of treatments/medications taken	0.5	1.0	1.4	-0.5	-1.2	-1.1
Average weekly spirits intake	0.3	0.4	0.6	0.8	0.5	0.6
Sensitivity / hurt feelings	1.7	3.0	6.6	2.6	1.4	0.5
Frequency of depressed mood in last 2 weeks	1.3	1.8	3.6	1.9	1.0	-1.0
Hearing difficulty/problems: Yes	0.3	0.4	1.1	-1.1	-0.1	-0.3
Relative age of first facial hair	1.0	2.0	4.3	0.7	1.1	-2.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	2.2	-0.8	-0.7	-1.5
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.9	0.9	1.7	-0.0
Ever had hysterectomy (womb removed)	0.6	0.6	1.2	-1.1	0.8	-0.1
Systolic blood pressure, automated reading	1.5	4.3	5.7	-2.4	-1.2	2.4
Eye problems/disorders: Diabetes related eye disease	3.0	3.3	4.1	-2.0	-1.6	1.8
Angina	3.0	3.9	4.8	-2.2	-1.7	2.0
Medication for hormone replacement therapy	3.2	3.6	5.9	2.1	2.4	0.6
Vitamin and mineral supplements	1.9	2.6	7.8	-0.1	0.0	2.8
Supplements: Zinc	0.7	0.8	1.6	1.3	-0.5	-0.7
Medication: Co-codamol	0.5	0.6	0.9	-0.9	-0.0	-0.9
Medication: Metformin	4.4	6.2	9.7	-3.0	-3.1	0.5
Diabetes (father)	2.1	2.6	4.6	-2.1	-1.0	-1.5
Diabetes (mother)	1.0	1.3	3.4	-0.7	-0.0	-1.8
Severe depression (siblings)	2.9	3.2	6.0	1.9	2.5	-0.3
Pack years adult smoking proportion	0.6	0.8	1.7	-1.3	0.9	-0.1
Impedance of leg (right)	0.2	1.0	2.2	0.9	-0.1	-1.5
Leg fat-free mass (left)	0.1	0.8	0.9	-0.9	-0.9	0.8
Trunk fat percentage	0.1	0.6	1.7	-0.3	-0.0	-1.3
Hand grip strength (right)	0.5	1.5	2.8	0.2	-1.7	1.3
Townsend deprivation index at recruitment	0.1	0.2	0.3	-0.6	-0.0	0.4
Current tobacco smoking	1.2	2.0	3.3	0.4	1.8	-1.6
Average weekly fortified wine intake	0.6	0.7	1.3	1.1	-0.8	0.3
Maternal smoking around birth	0.3	0.5	0.9	-0.9	0.7	-0.1
Fed-up feelings	0.4	0.8	1.1	1.0	0.3	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.1	1.8	1.2	-0.1
Relative age voice broke	0.2	0.3	0.6	0.2	0.8	-0.4
Taking other prescription medications	0.5	0.8	2.0	-0.5	0.3	-1.4
Age when periods started (menarche)	0.2	0.4	0.8	-0.9	0.6	-0.4
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.0	-1.4	0.1	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	2.2	4.9	7.7	-1.5	-2.8	2.2
Tinnitus: Yes, but not now, but have in the past	3.1	3.3	5.3	0.9	2.3	-1.9
Qualifications: CSEs or equivalent	4.4	5.8	17.2	-0.5	-0.1	-4.2
Serious illness, injury or assault to yourself	0.5	0.6	1.8	0.2	-0.2	-1.3
High blood pressure	1.7	4.9	7.4	-2.6	-2.7	0.5
Hayfever, allergic rhinitis or eczema	1.8	3.8	11.3	0.3	-0.2	-3.4
Multivitamins +/- minerals	0.8	1.0	2.9	0.3	-0.2	-1.7
Stomach or abdominal pain in last month	0.2	0.2	0.3	-0.5	-0.1	-0.6
Supplements: Glucosamine	2.2	2.8	3.6	1.2	1.9	-1.9
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.8	-0.7	0.1	-1.3
Medication: Atenolol	1.2	1.5	3.6	-1.9	-0.7	-0.5
Medication: Levothyroxine sodium	0.3	0.5	0.7	-0.6	-0.5	0.8
Sitting height	0.2	1.6	4.0	-0.2	-2.0	1.0
Chronic bronchitis/emphysema (father)	1.6	1.8	3.0	0.4	1.5	-1.7
High blood pressure (mother)	1.8	2.6	6.4	-0.8	-0.8	-2.5
Body mass index (BMI)	0.1	0.2	0.5	-0.7	-0.0	-0.4
Impedance of leg (left)	0.2	1.1	2.0	1.1	-0.1	-1.4
Leg predicted mass (left)	0.1	0.8	1.1	-1.0	-0.9	0.7
Trunk fat mass	0.1	0.4	0.5	-0.6	-0.4	-0.7
Waist circumference	0.3	1.1	2.5	-1.6	-0.7	-0.6
Number of incorrect matches in round	1.1	1.8	3.5	-0.8	-1.1	1.9
Past tobacco smoking	0.1	0.3	0.6	0.8	0.0	-0.4
Alcohol usually taken with meals	0.2	0.4	0.7	-0.4	-0.5	-0.8
Nervous feelings	0.5	0.9	2.7	1.6	0.0	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.2	1.4	-1.2	-1.0	-1.0
Hearing difficulty/problems with background noise	1.5	2.4	3.7	1.0	1.9	-1.6
Hair/balding pattern: Pattern 2	1.6	2.0	3.1	1.8	1.4	-0.9
Had menopause	1.8	2.2	4.0	1.6	2.0	0.3
Had other major operations	0.2	0.2	0.3	-0.3	0.5	-0.6
Forced vital capacity (FVC)	0.5	1.8	2.3	1.4	1.5	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.1	5.9	-1.4	-2.4	1.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.0	-0.6	-0.2	-1.0
Qualifications: None of the above	0.8	1.7	3.2	-1.2	1.8	0.7
Financial difficulties in last 2 years	0.7	1.0	1.9	0.0	1.0	-1.4
Mouth/teeth dental problems	0.6	0.9	2.3	0.7	-0.2	1.5
Heart attack	1.2	1.5	3.6	-1.9	-0.9	0.0
Allergy	2.4	5.6	16.7	0.1	0.2	4.1
Pain all over the body in last month	0.0	0.0	0.1	0.1	-0.1	-0.3
Diabetes (self-reported)	3.8	5.9	11.9	-3.5	-2.4	0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.7	-0.1	-0.5	-1.3
Medication: Ramipril	5.0	6.4	12.3	-2.0	-3.5	1.7
Medication: Simvastatin	2.6	3.9	5.8	-2.1	-2.4	1.3
Fluid intelligence score	0.2	0.4	1.0	0.4	-0.4	-1.0
Illnesses of siblings	0.8	1.1	3.0	1.7	0.4	0.5
Neuroticism score	0.4	0.8	2.1	1.4	0.6	-0.2
Weight	0.1	0.7	1.1	-1.0	-1.0	0.3
Impedance of arm (right)	0.3	1.2	2.1	1.2	-0.1	-1.4
Arm fat percentage (right)	0.1	0.3	0.9	-0.0	-0.1	-1.0
Trunk fat-free mass	0.3	1.8	2.2	-1.3	-1.5	1.2
Hip circumference	0.2	1.0	2.2	0.2	0.8	-1.5
Time employed in main current job	0.9	1.0	2.6	-0.4	-1.6	0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.4	-0.5	-0.3
Father’s age at death	2.4	3.2	6.5	2.6	1.6	0.8
Worrier / anxious feelings	0.2	0.4	0.8	0.9	-0.2	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.7	0.6	0.1	-1.3
Falls in the last year	0.1	0.2	0.3	-0.3	-0.3	-0.5
Hair/balding pattern: Pattern 3	0.8	1.2	1.7	-0.6	-1.2	1.3
Number of live births	0.4	0.5	1.6	0.0	1.3	0.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.0	0.8	0.8	1.4
Pulse rate	2.3	3.8	8.1	-0.8	-1.6	-2.9
Happiness	0.7	0.9	1.5	1.2	-0.2	-1.1
Noisy workplace	0.3	0.4	0.6	-0.8	0.0	-0.8
Qualifications: A levels/AS levels or equivalent	1.2	2.6	7.9	2.8	-0.1	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.4	0.8	1.6	-0.5
Mouth/teeth dental problems: Dentures	0.9	1.6	2.4	0.3	1.6	-1.5
Asthma	2.0	3.9	11.6	0.1	-0.1	-3.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.3	-0.5	0.4	-0.4
Medication: Cholesterol lowering	0.9	1.4	1.8	-1.0	-1.3	1.2
Depression (self-reported)	0.5	0.6	1.6	0.4	1.3	-0.2
Medication: Lansoprazole	0.2	0.2	0.5	0.2	-0.7	-0.3
Prospective memory result	2.2	2.7	4.1	-2.0	-1.9	0.7
Lung cancer (father)	0.5	0.6	1.2	-0.7	1.1	-0.4
Illnesses of mother	0.6	0.8	2.2	0.1	-0.1	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.4	1.4	0.5	1.9
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	0.6	-0.4	-0.4
Impedance of arm (left)	0.2	0.8	1.4	1.0	-0.2	-1.2
Arm fat mass (right)	0.1	0.3	0.4	-0.5	-0.7	-0.5
Trunk predicted mass	0.3	1.8	2.2	-1.3	-1.5	1.2
Standing height	0.2	1.6	3.2	-0.6	-1.8	1.1
Length of working week for main job	1.7	1.9	3.3	1.8	1.3	0.8
Exposure to tobacco smoke at home	2.8	3.2	6.7	2.6	1.6	-0.6
Breastfed as a baby	0.3	0.3	0.5	-0.4	0.7	-0.6
Tense / ‘highly strung’	0.1	0.1	0.2	0.3	0.4	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.8	4.2	5.6	1.9	2.4	-1.8
Hair/balding pattern: Pattern 4	2.3	5.6	9.2	-2.2	-1.7	3.0
Birth weight of first child	0.2	0.4	1.0	-0.3	1.0	-0.2
Peak expiratory flow (PEF)	0.4	1.0	1.6	-0.9	-0.6	-1.3
Pulse wave reflection index	0.7	0.9	1.6	0.9	0.5	1.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.3	0.5	1.1	-0.1
Loud music exposure frequency	0.7	0.8	1.2	-0.7	-1.1	-0.9
Qualifications: O levels/GCSEs or equivalent	3.1	5.0	13.8	3.7	1.0	-0.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	-0.7	-0.1	-0.8
Blood clot in the leg (DVT)	2.2	2.8	5.0	-2.2	-1.8	-0.1
Medication: Paracetamol	0.1	0.1	0.3	-0.2	-0.1	-0.5
Headache pain in last month	0.1	0.1	0.2	0.3	0.5	-0.2
Medication for cholesterol, blood pressure or diabetes	2.8	4.6	9.1	1.9	3.0	-1.1
Glaucoma (self-reported)	1.4	1.7	2.4	-1.5	-0.9	1.4
Gout (self-reported)	1.0	1.4	2.6	0.6	1.1	1.6
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.6	-1.2	-0.1	1.2
Medication: Amlodipine	1.3	1.8	3.5	-1.0	-1.9	0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.2	0.4	0.3	-1.1
Birth weight	0.5	1.1	1.4	0.9	1.2	-1.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.7	-0.8	0.7	0.5
High blood pressure (siblings)	0.7	1.0	2.2	-0.9	-0.2	-1.5
Forced vital capacity (FVC), Best measure	0.6	2.2	3.2	1.8	1.3	1.4
Body fat percentage	0.1	0.3	0.8	0.0	0.1	-0.9
Leg fat percentage (right)	0.0	0.1	0.2	0.0	0.4	-0.1
Arm fat-free mass (right)	0.2	0.9	1.0	-0.9	-0.8	1.0
Exposure to tobacco smoke outside home	0.2	0.3	0.3	-0.5	0.5	0.5
Comparative body size at age 10	0.3	0.9	2.1	0.6	1.5	0.5
Number of full brothers	1.0	1.2	2.9	-1.7	-0.5	0.7
Worry too long after embarrassment	0.4	0.6	1.2	0.8	0.1	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.2	0.5	0.8	-1.1
Wheeze or whistling in the chest in last year	2.5	4.5	12.7	-0.4	0.8	-3.6
Number of children fathered	1.7	2.0	3.2	-1.5	-0.5	1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	1.8	-0.7	-1.4	-0.6
Age at first live birth	0.3	0.5	0.7	0.8	-0.5	0.7
Pulse wave peak to peak time	0.2	0.2	0.3	-0.5	0.2	0.6
Health satisfaction	1.1	1.4	2.5	-0.9	-0.9	-1.6
Shortness of breath walking on level ground	0.8	0.9	1.9	0.5	-1.4	-0.7
Qualifications: College or University degree	0.4	1.1	2.9	1.7	-0.7	0.2
Eye problems/disorders: None of the above	0.3	0.4	1.0	1.0	-0.2	-0.3
Mouth/teeth dental problems: Loose teeth	0.5	0.7	1.0	0.6	1.0	0.8
Emphysema/chronic bronchitis	1.4	1.5	2.1	1.3	0.9	-1.4
Medication for pain relief, constipation, heartburn	1.4	2.4	4.8	2.2	1.6	0.1
Neck or shoulder pain in last month	0.8	1.1	3.1	0.0	0.4	-1.8
Medication: Blood pressure	0.9	1.6	3.3	-1.2	-1.8	0.4
Angina (self-reported)	2.4	3.2	3.7	-1.9	-1.5	1.9
Migraine (self-reported)	0.6	0.8	1.5	0.2	-0.9	-1.2
Medication: Ibuprofen	0.4	0.5	0.9	-0.3	0.7	-0.9
Medication: Allopurinol	0.4	0.6	1.5	-0.4	1.2	0.5
Medication: Omeprazole	6.1	7.2	11.8	-3.4	-2.9	-1.1
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.4	0.4	-0.6
Mean time to correctly identify matches	1.4	2.7	5.9	-2.4	-1.3	-0.7
Heart disease (mother)	0.7	0.8	1.4	-0.4	1.2	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.5	-0.7	-0.2	-0.7
Whole body fat mass	0.1	0.3	0.5	-0.4	-0.3	-0.7
Leg fat mass (right)	0.0	0.0	0.0	-0.2	0.2	0.0
Arm predicted mass (right)	0.2	0.8	1.2	-0.9	-0.7	1.1
Pulse rate, automated reading	1.0	3.3	9.2	0.0	-0.8	-3.0
Alcohol intake frequency.	0.2	0.6	1.1	0.3	1.1	-0.7
Comparative height size at age 10	0.5	3.0	4.2	-0.8	-2.0	2.1
Number of full sisters	0.7	0.9	1.9	-1.4	-0.0	-0.9
Suffer from ‘nerves’	0.7	1.1	1.6	-0.6	-1.2	-1.2
Overall health rating	2.9	6.3	10.8	-3.3	-1.4	-2.5
Chest pain or discomfort	3.8	5.5	11.9	-1.9	-1.0	-3.5
Had major operations	0.3	0.4	1.0	0.2	-0.0	-1.0
Age at last live birth	0.2	0.3	0.7	0.0	-0.9	-0.2
Family relationship satisfaction	0.5	0.6	1.6	-0.5	-0.2	-1.3
Leg pain on walking	0.4	0.5	0.8	0.9	0.7	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.7	-1.3	-0.8	-0.6
Commuting to job workplace: Car/motor vehicle	1.7	1.9	5.0	-0.9	0.2	-2.2
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.8	-0.8	-1.7	1.2
Medication: Aspirin	0.8	1.1	1.5	-0.7	-1.1	1.2
Supplements: Vitamin C	0.7	0.8	2.4	-0.1	0.0	-1.6
Knee pain experienced in last month	3.1	4.7	8.0	1.2	2.8	-2.2
Hypertension (Self-reported)	1.5	4.1	6.3	-2.5	-2.4	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.8	-0.7	-0.9	-0.4
Illnesses of father: Heart disease	1.6	2.2	3.5	-1.9	-1.7	-0.4
Illnesses of siblings: Diabetes	0.7	0.8	1.6	-1.3	-0.5	0.8
Smoking status: Previous	0.5	0.7	1.1	-1.0	-0.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.6	-0.4	-0.8	0.2
Whole body fat-free mass	0.2	1.3	1.5	-1.2	-1.2	1.0
Leg fat-free mass (right)	0.2	0.8	0.9	-0.9	-0.9	0.9
Arm fat percentage (left)	0.1	0.2	0.6	-0.1	-0.0	-0.8
Average weekly red wine intake	0.1	0.1	0.2	0.4	0.1	-0.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.1	0.5	-0.2
Mood swings	0.7	1.3	2.2	1.3	1.5	0.3
Loneliness, isolation	1.0	1.4	2.8	1.7	1.1	-0.3
Long-standing illness, disability or infirmity	1.7	2.6	6.7	-1.0	-0.2	-2.6
Ever had bowel cancer screening	0.3	0.3	0.5	-0.7	0.2	-0.7
Diabetes diagnosed by doctor	3.9	6.3	9.9	-3.1	-2.9	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.0	0.3	0.4	1.0
Friendships satisfaction	0.7	0.8	1.5	1.2	1.0	-0.3
Qualifications: nursing, teaching	0.9	1.4	3.0	1.7	0.1	-1.1
Commuting to job workplace: Walk	0.9	1.0	2.4	0.8	-0.1	1.5
Eye problems/disorders: Cataract	1.8	2.1	5.9	0.5	2.4	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.3	-0.3	-1.1	-0.6
Medication for cholesterol	0.2	0.3	0.9	0.1	-0.1	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.2	-0.2	0.1	1.1
Back pain experienced in last month	1.7	2.5	5.1	-1.3	-0.9	-2.3
Mineral and other dietary supplements	3.1	4.1	10.1	-0.7	-1.3	3.2
Breast cancer (self-reported)	0.0	0.1	0.2	0.0	0.0	0.4
Asthma (self-reported)	2.1	4.2	12.6	0.3	0.1	-3.6
Osteoporosis (self-reported)	0.3	0.4	0.7	0.3	-0.7	-0.8
Osteoarthritis (self-reported)	1.3	1.7	2.9	1.5	1.7	-0.3
Medication: Aspirin	1.2	1.6	2.8	-0.9	-1.7	1.0
Medication: Gliclazide	1.0	1.1	1.4	-1.2	-1.1	-0.9
Illnesses of father: None of the above (group 1)	1.8	2.2	4.8	2.2	1.3	-0.2
Smoking status: Current	1.4	2.2	3.8	0.7	1.9	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	0.9	0.8	1.0	0.8
Whole body water mass	0.2	1.2	1.3	-1.0	-1.1	1.1
Leg predicted mass (right)	0.2	0.8	0.8	-0.9	-0.9	0.9
Arm fat mass (left)	0.0	0.2	0.3	-0.4	-0.5	-0.2
Number of self-reported non-cancer illnesses	2.8	4.9	8.7	-2.9	-2.3	-0.8
Average weekly champagne plus white wine intake	1.0	1.4	3.2	1.8	-0.1	-1.0
Miserableness	0.5	0.9	1.4	1.0	1.2	-0.5
Guilty feelings	0.0	0.0	0.1	0.3	0.1	-0.1
Wears glasses or contact lenses	0.1	0.1	0.4	0.2	-0.2	-0.6
Ever taken oral contraceptive pill	0.7	0.8	1.2	1.1	0.9	0.4
Hearing aid user	0.7	0.8	2.4	-1.6	0.0	-0.3
Mother’s age at death	4.5	5.6	8.6	2.4	2.9	-1.6
Financial situation satisfaction	0.6	0.8	1.3	0.4	1.0	-1.1
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.7	-0.9	0.3	-0.5
Commuting to job workplace: Public transport	1.8	2.1	4.4	2.1	1.0	0.9
Eye problems/disorders: Glaucoma	1.4	1.7	3.4	-1.8	-1.0	0.7
Medication: Blood pressure	2.7	5.2	10.2	-3.2	-2.3	0.4
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.8	0.8	1.7	-1.1
Supplements: Fish oil (including cod liver oil)	1.3	1.7	4.0	0.8	0.6	-2.0
High cholesterol (Self-reported)	1.7	3.0	3.8	-1.5	-1.9	1.7
Medication: Bendroflumethiazide	0.2	0.3	0.8	-0.4	-0.3	-0.9
Medication: Paracetamol	0.4	0.6	1.0	-0.3	-0.8	-1.0
Medication: Lisinopril	1.1	1.5	2.2	-1.5	-1.5	-0.2
Medication: Atorvastatin	2.2	2.7	3.2	-1.7	-1.4	1.8
Illnesses of father: High blood pressure	0.9	1.1	1.7	-1.3	-0.2	-1.3
Alcohol drinker status: Never	1.5	1.8	3.7	0.7	1.1	1.9
Ever smoked	0.0	0.0	0.0	-0.1	-0.1	0.2
Basal metabolic rate	0.2	1.2	1.6	-1.1	-1.3	0.9
Leg fat percentage (left)	0.0	0.1	0.1	0.1	0.4	-0.2
Arm fat-free mass (left)	0.1	0.7	1.3	-0.6	-0.7	1.2
Number of operations (self-reported)	1.3	1.9	3.3	-1.8	0.8	-1.3
Average weekly beer plus cider intake	0.2	0.3	0.3	-0.6	0.6	-0.4
Irritability	0.4	0.7	1.5	0.1	0.8	-1.2
Risk taking	1.3	1.9	3.4	-0.1	1.8	-1.5
Ever had prostate specific antigen (PSA) test	1.7	1.9	3.5	-1.5	-1.9	-0.2
Fractured/broken bones in last 5 years	1.3	1.6	3.3	-0.0	1.3	-1.8
Age started oral contraceptive pill	0.4	0.6	0.8	0.7	0.9	0.7
Diastolic blood pressure, automated reading	0.1	0.4	1.0	-1.0	-0.3	-0.1
Ever depressed for a whole week	0.3	0.3	0.6	0.2	-0.8	-0.7
Unable to work because of sickness or disability	0.3	0.4	0.7	-0.8	0.7	-0.1
Commuting to job workplace: Cycle	0.6	0.7	1.2	0.4	1.1	0.9
Myopia	0.7	1.1	2.4	1.6	0.6	0.7
Vascular/heart problems diagnosed by doctor	3.2	8.8	13.1	3.4	3.6	-1.3
Cholesterol lowering medication	3.2	4.7	5.8	-2.4	-2.3	1.7
Medication: Omeprazole (e.g. Zanprol)	6.7	8.1	15.6	-3.9	-2.6	-1.4
Pain experienced in last month	1.5	2.5	7.0	0.6	-0.4	2.6
Supplements: Calcium	2.0	2.2	5.3	2.3	0.2	-1.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.2	0.5	-0.4	-0.4
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.3	-1.8	-0.8	0.2
Deep venous thrombosis (DVT) (self-reported)	2.4	3.1	5.4	-2.3	-2.0	-0.2
Heart disease (siblings)	2.2	2.7	5.2	-2.3	-1.5	-0.7
Alcohol drinker status: Previous	1.7	1.9	4.4	-0.0	1.1	-2.1
Pack years of smoking	0.7	1.1	1.9	-1.4	1.1	0.1
Impedance of whole body	0.3	1.4	2.8	1.1	-0.1	-1.7
Leg fat mass (left)	0.0	0.0	0.1	-0.0	0.3	0.1
Arm predicted mass (left)	0.2	0.9	1.4	-0.8	-0.9	1.2