Best TWAS P=2.28e-60 · Best GWAS P=9.12e-239 conditioned to 6.82e-108
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ARVCF | 0.06 | 0.02 | lasso | 4 | 0.05 | 1.6e-06 | 6.60 | 5.7 | 1.2e-08 | 0.01 | 0.15 | 0.10 | TRUE |
| 2 | GTEx | Brain Caudate basal ganglia | SLC25A1 | 0.24 | 0.11 | enet | 23 | 0.13 | 1.5e-04 | -0.58 | -8.0 | 1.7e-15 | 0.13 | 0.38 | 0.04 | TRUE |
| 3 | GTEx | Brain Caudate basal ganglia | GNB1L | 0.29 | 0.05 | lasso | 7 | 0.04 | 3.2e-02 | 1.58 | 7.4 | 1.5e-13 | -0.27 | 0.08 | 0.22 | TRUE |
| 4 | GTEx | Brain Cerebellar Hemisphere | MRPL40 | 0.44 | -0.01 | enet | 57 | 0.02 | 1.2e-01 | -1.13 | 7.0 | 2.0e-12 | -0.19 | 0.05 | 0.21 | TRUE |
| 5 | GTEx | Esophagus Mucosa | SEPT5 | 0.23 | 0.00 | enet | 25 | 0.01 | 3.4e-02 | 2.60 | -6.8 | 1.4e-11 | 0.07 | 0.13 | 0.07 | TRUE |
| 6 | GTEx | Skin Sun Exposed Lower leg | GNB1L | 0.09 | 0.00 | enet | 17 | 0.01 | 9.4e-02 | 1.38 | 7.1 | 9.6e-13 | -0.21 | 0.07 | 0.12 | FALSE |
| 7 | GTEx | Thyroid | TANGO2 | 0.17 | 0.04 | enet | 24 | 0.10 | 9.2e-08 | 2.87 | 5.8 | 6.8e-09 | -0.01 | 0.96 | 0.00 | FALSE |
| 8 | GTEx | Thyroid | AC006547.15 | 0.15 | 0.05 | enet | 28 | 0.08 | 1.5e-06 | 2.87 | 5.3 | 1.4e-07 | -0.03 | 0.98 | 0.00 | TRUE |
| 9 | METSIM | Adipose | SEPT5 | 0.11 | 0.04 | enet | 40 | 0.07 | 1.3e-10 | 3.49 | -16.4 | 2.3e-60 | 0.37 | 0.01 | 0.98 | TRUE |
| 10 | NTR | Blood | C22orf25 | 0.04 | 0.04 | bslmm | 464 | 0.04 | 8.3e-13 | 4.42 | -5.4 | 5.8e-08 | 0.07 | 1.00 | 0.00 | TRUE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DGCR5 | 0.07 | 0.01 | enet | 6 | 0.01 | 1.6e-02 | 4.56 | -5.9 | 3.5e-09 | 0.06 | 0.00 | 0.38 | TRUE |