Hub : Genes

TANGO2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.657	0.092	4.9e-07	0.063	NA	0.378	NA	0.172	0.01000	NA	1.1e-10	NA	3.5e-05
2	GTEx	Cells Transformed fibroblasts	0.109	0.043	5.3e-03	0.014	NA	0.028	NA	0.015	0.02800	NA	3.4e-03	NA	2.4e-02
3	GTEx	Pituitary	0.363	0.117	4.3e-03	0.068	NA	0.026	NA	0.047	0.00880	NA	7.2e-02	NA	2.6e-02
4	GTEx	Thyroid	0.169	0.046	1.4e-05	0.043	NA	0.095	NA	0.072	0.00032	NA	9.2e-08	NA	3.5e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	2.2	3.5	7.5	1.6	1.5	-1.4	2.7
Bipolar Disorder or Schizophrenia	1.3	3.2	8.2	1.8	0.4	-1.1	2.9
Depressed Affect (Nagel 2018)	0.2	0.5	1.0	-0.6	-0.8	-1.0	-0.2
Depression (Nagel 2018)	1.2	1.8	2.9	-1.2	-1.7	0.4	-1.7
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.8	-0.3	-1.3	1.0	-0.7
Neuroticism (Nagel 2018)	0.6	1.3	2.4	-1.5	0.1	-1.3	-1.1
Schizophrenia (2018)	0.4	0.8	2.4	0.7	-0.5	-0.3	1.6
Schizophrenia vs Biploar Disorder	0.6	0.8	2.3	-1.5	-0.6	-0.7	0.3
Worry (Nagel 2018)	1.1	2.3	4.6	-1.7	0.9	-2.1	0.8
Alzheimer’s Disease (in mother)	0.9	1.0	2.1	-1.2	0.7	1.4	0.4
Alzheimer’s Disease (in father)	0.6	0.6	1.5	1.2	0.5	0.5	-0.7
Alzheimer’s Disease (including proxy)	0.2	0.4	0.9	-0.4	0.6	0.9	-0.0
Crohns Disease (2017)	0.2	0.4	1.2	0.0	-0.5	-1.1	0.0
Irritable Bowel Disease (IBD)	0.2	0.5	1.9	1.4	0.2	-0.0	-0.4
Ulcerative Colitis (UC)	0.6	1.1	3.2	1.8	0.7	0.7	-0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.6	1.1	3.4	-0.1	-0.9	-1.8	0.5
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.8	-0.7	-0.8	1.7	0.3
Breast Cancer	0.9	2.3	6.6	1.0	-0.6	-1.0	-2.6
Ovarian Cancer	0.4	0.5	1.0	-1.0	0.2	0.3	1.0
Prostate Cancer	4.1	5.8	15.1	-3.9	-0.3	0.6	2.8
Age at First Birth	0.2	0.2	0.5	-0.2	0.4	0.7	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.5	0.7	0.1	0.5	-0.3
Coronary Artery Disease (CAD)	0.9	1.0	2.6	1.6	1.0	-0.1	0.7
Crohns Disease (2012)	1.2	1.9	2.4	-1.4	-1.5	-1.4	1.1
Mean Putamen Volume	0.6	0.7	2.5	0.0	-0.3	-0.5	1.6
Fasting Glucose	0.8	1.0	2.3	0.8	-0.9	-1.5	-0.4
HbA1C	0.7	0.8	1.6	1.3	-1.2	-0.1	0.1
HDL Cholesterol	0.0	0.0	0.1	-0.3	-0.1	-0.3	0.1
LDL Cholesterol	0.6	1.0	2.2	1.5	-0.6	0.3	-1.1
Lupus	0.1	0.1	0.3	-0.2	-0.2	-0.5	0.2
Neuroticism (2016)	1.3	1.9	4.3	-2.1	-0.8	-1.2	-1.0
Primary Biliary Cirrhosis	1.3	1.9	5.8	0.9	2.4	-0.3	0.8
Rheumatoid Arthritis	0.9	1.3	1.7	-1.3	1.3	1.3	-0.2
Schizophrenia (2014)	0.4	0.9	1.8	1.3	0.4	0.1	1.3
Triglycerides	0.7	1.1	3.3	0.0	-1.8	0.6	0.8
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.3	1.0	-1.2	-0.3	0.5
Ulcerative Colitis	0.8	1.1	2.4	1.6	0.3	1.4	0.0
Blood Eosinophil Count	1.7	13.2	24.6	5.0	0.2	2.5	-4.7
Blood Platelet Count	2.1	24.7	39.3	5.7	-3.5	3.8	-6.3
Blood Red Count	0.3	3.3	4.6	-2.1	-2.1	-0.0	2.1
Blood White Count	1.7	12.4	36.4	6.0	-1.8	3.1	-0.5
Heel T-Score	1.3	10.6	33.6	-1.9	0.3	2.3	5.8
BMI	1.4	8.1	20.7	2.0	-4.6	-0.5	-2.7
Height	0.1	1.4	2.8	0.3	-1.7	1.4	1.0
Waist Hip Ratio (WHR)	0.2	0.7	1.1	0.9	0.8	-1.1	-0.5
Systolic Blood Pressure	1.9	9.3	15.4	3.8	-0.0	3.9	-2.6
Smoking Status	0.7	1.6	3.1	1.8	-1.4	-0.9	-0.7
Allergy or Eczema	0.1	0.2	0.6	0.4	0.0	-0.1	-0.8
Cardiovascular Disease	1.5	5.0	8.3	2.9	-1.6	1.8	-2.4
Hypothyroidism (self reported)	0.4	0.9	2.7	-0.6	0.3	1.7	0.6
Respiratory disease	0.5	1.2	3.4	0.5	1.0	1.8	-0.3
Type 2 Diabetes (T2D) (2018)	1.7	3.2	8.7	0.8	-1.6	0.9	-3.0
Lung FEV1/FVC ratio	1.2	5.9	12.0	-0.2	-3.5	-3.0	-1.5
Lung FVC	0.2	1.1	2.9	0.7	-0.6	1.0	-1.7
Neuroticism	1.3	3.0	7.0	-1.3	-1.3	-2.7	-1.3
Chronotype (morning person)	1.2	2.8	3.5	1.8	-1.6	-1.9	1.3
Hair Pigment	0.2	6.3	20.5	-2.1	4.5	-0.0	0.2
Tanning	0.2	2.9	5.3	2.2	2.3	1.1	0.3
Hand grip strength (left)	0.2	0.5	1.6	0.3	0.2	1.3	-0.3
Number of treatments/medications taken	1.5	2.7	8.0	1.0	-1.3	-0.2	-2.8
Average weekly spirits intake	2.2	2.7	9.6	0.0	-1.1	0.1	3.1
Sensitivity / hurt feelings	0.4	0.8	1.4	-0.8	1.2	-0.8	-0.6
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.0	-0.4	-1.7	-0.2	-1.1
Hearing difficulty/problems: Yes	0.5	0.8	2.5	-0.6	-1.6	0.0	0.5
Relative age of first facial hair	0.8	1.7	2.8	-1.6	0.9	-1.7	0.8
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.7	0.8	-0.8	-0.8	0.5
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.6	-1.9	-0.6	0.7	-1.2
Ever had hysterectomy (womb removed)	3.7	4.1	7.1	-2.2	-2.7	2.0	0.8
Systolic blood pressure, automated reading	1.9	5.6	10.7	3.3	0.3	3.0	-1.6
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.7	-0.4	1.0	1.0	-1.3
Angina	2.5	3.3	6.7	1.0	-2.3	2.6	-0.7
Medication for hormone replacement therapy	1.3	1.5	3.7	-0.1	-1.0	1.1	-1.9
Vitamin and mineral supplements	0.4	0.5	1.1	1.0	-0.7	-0.8	0.0
Supplements: Zinc	1.5	1.6	3.9	-1.3	2.0	0.8	-0.1
Medication: Co-codamol	1.4	1.7	3.9	0.2	-2.0	-0.7	-1.5
Medication: Metformin	1.6	2.2	5.8	-0.3	-2.4	-0.2	-1.7
Diabetes (father)	1.2	1.5	2.9	1.7	0.3	-1.2	-1.2
Diabetes (mother)	1.6	2.0	5.1	-0.5	-2.3	1.1	-1.2
Severe depression (siblings)	0.3	0.3	0.5	0.4	0.7	0.4	-0.7
Pack years adult smoking proportion	0.4	0.5	2.1	-0.3	-1.4	-0.2	0.1
Impedance of leg (right)	2.1	10.3	18.1	-1.8	4.1	1.8	4.3
Leg fat-free mass (left)	1.1	5.7	13.3	1.7	-3.6	-1.1	-2.3
Trunk fat percentage	0.1	0.2	0.3	0.5	-0.6	0.6	0.0
Hand grip strength (right)	0.3	0.7	2.8	0.3	0.1	1.7	0.1
Townsend deprivation index at recruitment	1.5	2.1	5.0	0.9	-2.2	-0.4	-1.6
Current tobacco smoking	0.4	0.7	1.0	1.0	-1.0	-0.3	0.9
Average weekly fortified wine intake	2.0	2.4	3.3	-0.8	-1.6	-1.7	1.8
Maternal smoking around birth	0.1	0.2	0.4	0.2	-0.4	0.6	-0.4
Fed-up feelings	0.1	0.2	0.5	-0.6	-0.1	-0.7	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	5.6	-2.4	-1.7	-0.3	-1.3
Relative age voice broke	1.1	1.7	4.4	-1.4	0.1	-2.1	0.6
Taking other prescription medications	1.6	2.5	8.8	0.7	-0.5	-0.7	-3.0
Age when periods started (menarche)	0.6	1.5	4.5	0.2	0.6	1.1	-2.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.1	-0.8	-1.4	-0.2	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	2.9	1.6	-0.5	1.2	1.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.1	1.5	0.5	0.4	0.1
Qualifications: CSEs or equivalent	0.3	0.4	0.7	0.2	-0.9	0.6	-0.8
Serious illness, injury or assault to yourself	0.6	0.8	2.2	-0.8	-1.5	-0.5	-0.1
High blood pressure	1.1	2.9	5.9	2.4	-0.4	1.2	-2.0
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.0	0.6	1.0	-0.4	-0.8
Multivitamins +/- minerals	1.6	2.1	3.4	-0.2	1.5	1.8	-1.6
Stomach or abdominal pain in last month	0.9	1.2	3.6	1.9	1.0	0.1	0.4
Supplements: Glucosamine	0.4	0.5	1.8	0.2	0.2	0.0	-1.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.3	0.0	-1.1	-0.4	-0.1
Medication: Atenolol	0.6	0.8	1.8	0.7	-0.9	1.3	-0.4
Medication: Levothyroxine sodium	2.0	3.4	12.1	0.3	1.2	3.5	-0.1
Sitting height	0.1	0.7	1.6	-0.0	-1.2	1.2	0.0
Chronic bronchitis/emphysema (father)	1.1	1.3	2.8	-1.2	1.7	0.2	1.0
High blood pressure (mother)	0.9	1.3	2.5	1.2	-0.2	1.0	-1.6
Body mass index (BMI)	0.9	3.9	9.5	1.6	-3.1	-0.3	-1.9
Impedance of leg (left)	2.0	9.9	16.7	-1.5	4.1	2.4	3.9
Leg predicted mass (left)	1.0	5.4	12.7	1.6	-3.6	-1.0	-2.3
Trunk fat mass	0.2	0.9	2.6	0.8	-1.6	0.5	-0.6
Waist circumference	0.9	3.5	6.8	1.7	-2.6	-0.9	-1.8
Number of incorrect matches in round	1.5	2.4	5.5	0.3	2.4	-0.6	1.9
Past tobacco smoking	0.6	1.1	2.6	-1.6	-0.0	-1.3	0.3
Alcohol usually taken with meals	0.2	0.4	0.6	0.6	-0.6	0.5	0.8
Nervous feelings	1.8	3.3	6.9	-1.3	1.7	-1.3	2.6
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	4.2	-2.0	-1.8	-1.1	-1.4
Hearing difficulty/problems with background noise	1.6	2.5	6.8	-0.8	-1.6	-0.3	-2.6
Hair/balding pattern: Pattern 2	1.5	2.0	4.1	-1.0	-1.6	-0.5	-2.0
Had menopause	1.3	1.6	3.2	-1.8	0.3	-0.8	-1.6
Had other major operations	1.4	1.7	5.9	-0.3	-0.3	-2.4	0.8
Forced vital capacity (FVC)	0.1	0.3	0.7	0.0	0.2	0.8	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.1	1.4	-1.3	1.0	1.8
Ever unenthusiastic/disinterested for a whole week	2.2	2.7	5.2	-1.2	-2.1	-2.3	0.1
Qualifications: None of the above	0.4	0.8	2.1	1.0	-0.0	-0.2	-1.5
Financial difficulties in last 2 years	0.4	0.6	1.8	0.7	-1.4	-0.2	0.0
Mouth/teeth dental problems	0.2	0.3	0.5	-0.6	0.3	-0.7	0.5
Heart attack	1.8	2.3	7.3	0.9	1.0	2.7	0.3
Allergy	0.3	0.7	2.0	-0.3	-1.4	-0.3	0.7
Pain all over the body in last month	2.6	2.8	7.8	-0.1	-2.8	0.1	-1.8
Diabetes (self-reported)	1.5	2.3	4.7	1.0	-1.9	-0.5	-2.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.7	1.0	-0.6	-0.2	-1.3
Medication: Ramipril	0.9	1.1	3.7	1.9	-0.4	0.5	-0.5
Medication: Simvastatin	0.7	1.1	3.2	0.1	-1.0	1.8	-0.3
Fluid intelligence score	0.2	0.5	0.7	-0.6	-0.8	0.9	0.3
Illnesses of siblings	1.6	2.3	7.5	-0.9	0.6	-0.7	2.7
Neuroticism score	0.6	1.2	3.1	-1.2	-0.1	-1.8	-0.2
Weight	0.8	3.9	11.0	1.6	-3.3	0.0	-1.5
Impedance of arm (right)	2.3	10.5	19.7	-2.8	4.4	0.8	3.8
Arm fat percentage (right)	0.2	0.7	2.4	0.5	-1.6	-0.3	-0.1
Trunk fat-free mass	1.1	6.2	20.8	1.1	-4.6	-0.9	-1.4
Hip circumference	0.9	4.0	10.2	1.4	-3.2	-0.6	-1.8
Time employed in main current job	0.2	0.3	0.5	0.4	-0.6	0.7	-0.2
Alcohol intake versus 10 years previously	0.2	0.4	0.9	0.7	-0.2	-0.9	-0.3
Father’s age at death	0.4	0.6	1.6	-0.5	-0.2	-1.2	0.6
Worrier / anxious feelings	0.5	1.0	2.1	-0.9	1.5	-0.2	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.1	0.1	-1.4	-0.1	-1.5
Falls in the last year	2.5	3.4	10.9	-0.1	-3.3	-0.3	-1.6
Hair/balding pattern: Pattern 3	1.2	1.8	4.0	1.2	-2.0	0.1	1.3
Number of live births	1.5	2.2	4.3	-1.4	-1.3	-1.0	2.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.6	0.2	-0.4	0.5	-1.3
Pulse rate	0.8	1.3	5.0	-0.2	0.1	-2.2	-0.1
Happiness	1.9	2.3	4.7	-0.7	-1.8	-0.9	2.2
Noisy workplace	1.5	1.9	6.6	-0.4	-2.6	-0.5	0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.4	0.1	-0.0	-0.7	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.6	0.5	-0.7	-0.5	1.3
Mouth/teeth dental problems: Dentures	0.4	0.7	1.7	0.4	-0.3	1.3	0.8
Asthma	0.1	0.3	0.6	0.2	-0.1	0.7	-0.7
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.8	-1.7	-1.1	-1.3	0.2
Medication: Cholesterol lowering	1.2	1.8	4.2	0.5	-1.3	2.0	-1.0
Depression (self-reported)	2.2	2.7	4.8	-0.9	-1.9	-2.2	-1.1
Medication: Lansoprazole	0.5	0.6	1.8	-0.3	-0.7	1.3	0.1
Prospective memory result	1.1	1.3	4.0	-0.1	0.7	2.0	-0.9
Lung cancer (father)	1.6	1.9	2.4	1.5	0.9	1.4	-1.5
Illnesses of mother	0.5	0.7	1.8	0.5	0.7	0.0	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.4	0.9	0.4	0.5	-1.2
Pulse wave Arterial Stiffness index	0.5	0.6	1.3	-1.1	-0.6	-0.9	0.3
Impedance of arm (left)	1.8	8.3	16.5	-2.0	4.1	0.9	3.4
Arm fat mass (right)	0.6	2.5	8.4	0.6	-2.9	-0.6	-0.8
Trunk predicted mass	1.1	6.5	21.8	1.1	-4.7	-1.0	-1.4
Standing height	0.1	0.5	1.1	-0.0	-0.9	0.5	1.0
Length of working week for main job	0.8	0.9	1.7	-1.2	-0.7	-0.2	-1.3
Exposure to tobacco smoke at home	1.4	1.5	5.5	0.1	-0.5	0.6	-2.3
Breastfed as a baby	0.5	0.7	1.4	1.0	0.1	0.4	-1.2
Tense / ‘highly strung’	0.7	1.2	2.7	-1.6	-0.6	-1.2	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	3.2	4.9	13.9	-1.1	-1.5	-1.5	-3.7
Hair/balding pattern: Pattern 4	0.2	0.4	1.4	1.2	0.4	-0.3	0.3
Birth weight of first child	0.2	0.4	1.1	-1.1	0.1	0.1	0.6
Peak expiratory flow (PEF)	0.3	0.7	2.0	-0.6	-1.4	0.6	0.5
Pulse wave reflection index	2.5	3.1	10.5	-3.2	-0.4	-1.2	0.6
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.7	-1.3	0.2	0.8	-0.7
Loud music exposure frequency	0.8	0.9	2.0	1.4	0.5	1.2	0.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	0.7	0.2	-0.6	-0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.4	0.6	0.0	-0.2	-0.2
Blood clot in the leg (DVT)	0.5	0.6	1.4	-1.2	-1.0	-0.3	-0.3
Medication: Paracetamol	1.5	2.5	6.0	1.7	-0.5	1.0	-2.4
Headache pain in last month	0.8	1.3	5.0	0.1	0.4	0.4	2.2
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	6.3	-1.2	1.5	-1.4	2.5
Glaucoma (self-reported)	0.5	0.6	1.1	0.9	-0.3	0.6	-1.1
Gout (self-reported)	0.8	1.1	2.7	-1.1	0.1	-1.7	0.5
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	6.1	-0.2	0.8	2.5	0.5
Medication: Amlodipine	0.4	0.6	1.3	0.3	-1.0	0.1	-1.1
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.6	0.5	-0.1	-0.8	-0.5
Birth weight	0.4	0.9	2.6	0.6	0.3	-0.7	-1.6
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.2	0.6	-0.2	-0.8	-1.1
High blood pressure (siblings)	1.3	1.9	7.1	0.3	-0.4	-0.4	-2.7
Forced vital capacity (FVC), Best measure	0.1	0.5	1.2	0.3	0.7	1.1	-0.3
Body fat percentage	0.1	0.3	0.7	0.6	-0.8	0.6	0.2
Leg fat percentage (right)	0.2	0.6	1.8	0.5	-1.4	0.5	-0.2
Arm fat-free mass (right)	1.4	7.0	18.9	2.0	-4.3	-0.5	-2.3
Exposure to tobacco smoke outside home	2.6	3.4	6.5	1.3	0.2	2.6	-2.3
Comparative body size at age 10	0.5	1.5	3.8	1.3	-0.7	-0.1	-1.9
Number of full brothers	0.8	1.0	2.2	0.4	-0.9	-1.5	0.9
Worry too long after embarrassment	0.9	1.5	3.0	-0.0	1.6	0.7	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.1	0.7	0.9	0.8	-1.1
Wheeze or whistling in the chest in last year	0.2	0.4	1.4	0.3	-1.2	-0.1	-0.6
Number of children fathered	0.2	0.2	0.6	-0.1	-0.2	0.7	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	5.3	-0.8	2.3	-1.3	0.7
Age at first live birth	0.1	0.1	0.4	0.3	0.0	0.1	0.7
Pulse wave peak to peak time	0.5	0.6	1.4	1.2	0.6	0.8	-0.4
Health satisfaction	0.1	0.2	0.4	-0.6	0.1	-0.4	0.4
Shortness of breath walking on level ground	1.3	1.6	3.4	1.3	0.9	0.6	-1.8
Qualifications: College or University degree	0.2	0.6	1.2	1.1	-1.0	-0.3	0.5
Eye problems/disorders: None of the above	0.9	1.0	3.2	1.8	-0.0	-0.1	0.9
Mouth/teeth dental problems: Loose teeth	1.6	2.0	4.6	-1.0	-1.4	-2.1	-0.5
Emphysema/chronic bronchitis	1.1	1.3	3.7	0.5	1.0	1.9	-0.5
Medication for pain relief, constipation, heartburn	0.4	0.7	1.9	0.1	0.9	-0.4	1.4
Neck or shoulder pain in last month	2.9	4.1	7.7	2.1	-0.6	2.0	-2.8
Medication: Blood pressure	2.1	3.6	6.1	2.1	-1.9	0.6	-2.5
Angina (self-reported)	2.6	3.4	6.5	1.2	-2.4	2.5	-0.4
Migraine (self-reported)	1.0	1.2	3.3	-1.8	0.6	1.0	0.1
Medication: Ibuprofen	1.1	1.3	2.4	-1.3	-1.0	-1.6	0.0
Medication: Allopurinol	0.3	0.4	0.9	-0.0	-0.9	-0.9	-0.4
Medication: Omeprazole	0.5	0.6	2.3	-0.1	0.3	-1.5	0.3
Medication: Seretide 50 evohaler	1.5	1.8	5.8	0.7	2.4	0.2	-0.8
Mean time to correctly identify matches	0.6	1.1	3.3	-0.7	-0.7	-1.8	-0.2
Heart disease (mother)	0.1	0.1	0.1	0.0	-0.4	-0.3	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.5	-0.5	-1.0	0.8	-1.9
Whole body fat mass	0.3	1.3	3.6	1.0	-1.9	0.2	-0.7
Leg fat mass (right)	0.5	1.9	4.9	1.2	-2.2	0.3	-1.1
Arm predicted mass (right)	1.5	7.8	21.3	1.9	-4.6	-0.5	-2.4
Pulse rate, automated reading	0.6	2.0	3.9	0.7	0.4	-1.9	2.0
Alcohol intake frequency.	1.0	2.4	6.6	-0.3	-2.6	-0.9	1.4
Comparative height size at age 10	0.2	0.9	2.8	-0.3	-0.0	0.8	1.7
Number of full sisters	0.9	1.1	2.3	0.7	-1.2	-1.5	0.0
Suffer from ‘nerves’	1.9	3.0	5.1	-2.1	-0.8	-2.2	1.4
Overall health rating	0.8	1.7	3.4	-0.6	-1.6	-0.7	1.8
Chest pain or discomfort	1.2	1.7	3.6	0.9	-1.9	0.8	-1.2
Had major operations	0.7	0.8	1.9	-0.1	-1.4	0.7	0.9
Age at last live birth	0.7	1.0	1.6	-1.3	-1.1	-1.2	-0.1
Family relationship satisfaction	0.2	0.2	0.5	-0.7	-0.3	0.2	0.6
Leg pain on walking	0.8	1.0	3.8	0.4	-0.2	-0.1	-2.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.7	-0.5	0.3	0.8	-0.4
Commuting to job workplace: Car/motor vehicle	1.8	2.0	4.6	-0.6	-0.1	2.1	-1.7
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.8	0.1	1.9	1.0	-0.8
Medication: Aspirin	1.4	1.8	6.9	0.5	0.0	2.6	0.3
Supplements: Vitamin C	0.5	0.6	1.4	-1.2	0.8	0.6	0.1
Knee pain experienced in last month	0.8	1.2	3.5	-0.2	-1.9	-0.3	-1.1
Hypertension (Self-reported)	0.9	2.6	4.7	2.2	-0.9	1.3	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	4.6	-0.5	-0.4	-2.1	0.1
Illnesses of father: Heart disease	0.6	0.9	2.2	0.5	-0.3	1.5	-1.0
Illnesses of siblings: Diabetes	1.2	1.5	3.2	1.0	0.3	1.3	-1.8
Smoking status: Previous	0.4	0.5	1.1	1.1	0.3	0.4	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.4	1.2	-0.1	-0.5	0.7
Whole body fat-free mass	1.1	6.5	18.8	1.5	-4.3	-1.1	-1.9
Leg fat-free mass (right)	1.2	6.2	13.7	1.9	-3.7	-0.8	-2.6
Arm fat percentage (left)	0.3	1.1	3.1	1.0	-1.8	-0.3	-0.4
Average weekly red wine intake	1.8	2.6	5.2	1.9	1.0	2.3	0.8
Handedness (chirality/laterality): Left-handed	1.4	1.7	4.4	-0.3	-0.1	-2.1	-1.5
Mood swings	0.1	0.2	0.3	0.3	-0.1	-0.5	0.6
Loneliness, isolation	0.9	1.2	2.1	-1.4	-1.4	-0.8	-0.2
Long-standing illness, disability or infirmity	1.4	2.1	6.9	0.6	-2.6	-0.9	-0.6
Ever had bowel cancer screening	1.4	1.7	5.6	-0.4	-0.7	-0.8	-2.4
Diabetes diagnosed by doctor	1.3	2.1	4.9	1.0	-1.5	-0.6	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.7	5.8	0.0	2.4	1.0	-2.0
Friendships satisfaction	1.0	1.3	4.4	2.1	-0.4	-0.5	0.5
Qualifications: nursing, teaching	0.8	1.2	2.0	-1.1	1.2	0.5	-1.4
Commuting to job workplace: Walk	0.4	0.5	1.5	0.0	-0.5	-0.4	1.2
Eye problems/disorders: Cataract	0.4	0.5	0.9	-0.6	0.8	-1.0	-0.0
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	6.2	1.1	-0.4	-0.0	-2.5
Medication for cholesterol	0.7	1.0	2.2	-0.3	0.9	-1.5	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	1.9	0.7	-1.2	-1.3	-1.4
Back pain experienced in last month	1.7	2.4	8.0	-1.0	-2.8	-0.5	-0.7
Mineral and other dietary supplements	1.0	1.4	3.8	-0.4	-1.9	-1.1	0.7
Breast cancer (self-reported)	0.3	0.3	0.9	-0.3	0.5	-1.0	-0.1
Asthma (self-reported)	0.1	0.3	0.7	0.0	-0.3	0.8	-0.6
Osteoporosis (self-reported)	0.5	0.6	1.1	-0.0	0.8	1.0	0.7
Osteoarthritis (self-reported)	0.5	0.7	2.5	-0.3	-1.6	-0.2	-0.1
Medication: Aspirin	1.0	1.3	4.9	0.4	-0.3	2.2	0.5
Medication: Gliclazide	3.0	3.3	5.1	1.8	-2.3	-1.0	-2.0
Illnesses of father: None of the above (group 1)	1.2	1.5	2.8	-0.8	-1.0	-1.7	1.2
Smoking status: Current	0.5	0.8	1.3	1.2	-1.0	-0.5	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.5	0.5	0.7	-0.8	-1.2
Whole body water mass	1.1	6.5	19.0	1.4	-4.4	-1.0	-2.0
Leg predicted mass (right)	1.1	6.1	13.1	1.9	-3.6	-0.8	-2.7
Arm fat mass (left)	0.7	2.7	9.0	0.8	-3.0	-0.6	-1.0
Number of self-reported non-cancer illnesses	1.9	3.2	7.1	2.0	-1.3	0.4	-2.7
Average weekly champagne plus white wine intake	0.5	0.7	1.7	0.1	0.1	-1.3	-1.0
Miserableness	0.1	0.2	0.7	-0.8	-0.4	-0.3	0.2
Guilty feelings	1.6	2.3	7.7	-0.7	-0.5	-1.0	-2.8
Wears glasses or contact lenses	0.1	0.1	0.4	0.2	0.6	-0.0	-0.2
Ever taken oral contraceptive pill	0.2	0.3	0.4	0.7	-0.2	-0.5	-0.6
Hearing aid user	1.3	1.5	4.0	-2.0	-0.6	0.7	1.0
Mother’s age at death	1.3	1.6	5.0	-2.2	-0.2	0.0	-1.1
Financial situation satisfaction	0.2	0.2	0.5	0.4	-0.7	-0.4	0.2
Tinnitus: Yes, now most or all of the time	1.5	1.8	5.4	0.1	2.3	1.2	0.7
Commuting to job workplace: Public transport	1.0	1.2	2.0	1.1	0.4	-1.4	1.1
Eye problems/disorders: Glaucoma	0.4	0.5	1.1	-0.0	0.1	1.1	-0.8
Medication: Blood pressure	0.9	1.7	4.7	0.9	-0.9	2.2	-0.4
Pain type(s) experienced in last month: Hip pain	1.6	2.0	5.4	1.0	-1.1	-0.4	-2.3
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.8	-0.1	0.6	1.7	0.5
High cholesterol (Self-reported)	0.7	1.3	4.3	-0.3	-2.1	-0.1	-0.8
Medication: Bendroflumethiazide	0.5	0.7	1.4	0.1	-1.0	1.2	-0.6
Medication: Paracetamol	0.9	1.3	3.6	1.0	-0.9	0.0	-1.9
Medication: Lisinopril	1.2	1.5	4.5	1.1	0.6	2.1	-0.2
Medication: Atorvastatin	0.6	0.7	2.1	-0.2	-1.4	0.5	-0.7
Illnesses of father: High blood pressure	0.8	1.0	1.4	-0.3	1.1	1.2	-1.2
Alcohol drinker status: Never	0.9	1.0	2.8	0.5	-1.7	0.9	-0.5
Ever smoked	1.0	1.8	3.9	1.8	-0.4	2.0	0.2
Basal metabolic rate	1.1	6.0	17.7	1.6	-4.2	-0.8	-1.8
Leg fat percentage (left)	0.2	0.8	2.1	0.7	-1.4	0.7	-0.4
Arm fat-free mass (left)	1.1	5.8	17.0	1.5	-4.1	-0.6	-1.9
Number of operations (self-reported)	1.8	2.6	6.5	-1.5	-2.5	-1.1	-0.8
Average weekly beer plus cider intake	0.9	1.3	3.8	0.4	1.9	1.0	0.3
Irritability	1.9	3.2	6.2	-0.5	-2.4	-0.7	-2.5
Risk taking	1.0	1.4	4.9	-0.5	-2.2	-0.6	0.1
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.1	0.8	-0.3	0.9	1.1
Fractured/broken bones in last 5 years	1.3	1.7	5.2	0.6	-0.3	-1.1	-2.3
Age started oral contraceptive pill	0.3	0.4	0.8	0.3	0.4	-0.8	-0.9
Diastolic blood pressure, automated reading	0.2	0.7	1.6	1.3	-0.0	0.1	1.1
Ever depressed for a whole week	1.3	1.6	4.5	-0.2	-2.1	-1.3	0.5
Unable to work because of sickness or disability	1.1	1.5	2.8	-1.5	-1.7	-0.9	-0.4
Commuting to job workplace: Cycle	0.9	1.1	2.3	1.4	-0.3	-1.5	-0.1
Myopia	0.4	0.6	1.8	0.3	0.7	-0.4	1.3
Vascular/heart problems diagnosed by doctor	1.5	4.2	6.6	-2.4	0.5	-2.1	2.6
Cholesterol lowering medication	0.3	0.4	1.3	-0.1	-1.1	0.3	0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.5	-0.1	-0.2	-1.2	0.3
Pain experienced in last month	1.6	2.7	8.2	-0.5	2.9	-0.1	1.5
Supplements: Calcium	1.4	1.5	4.6	-2.1	1.0	-0.4	0.5
Basal cell carcinoma (self-reported)	0.3	0.3	1.1	1.0	0.3	-0.2	-0.3
Heart attack/myocardial infarction (self-reported)	2.1	2.7	9.1	0.9	0.8	3.0	0.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.0	-1.4	-0.6	-0.3	-0.1
Heart disease (siblings)	2.5	3.0	6.4	1.1	-2.5	0.3	-2.1
Alcohol drinker status: Previous	0.5	0.5	1.0	-0.9	-0.0	-1.0	-0.6
Pack years of smoking	0.3	0.5	1.8	0.1	-1.4	0.0	-0.1
Impedance of whole body	2.1	10.9	20.4	-1.9	4.5	1.6	4.1
Leg fat mass (left)	0.6	2.3	5.5	1.4	-2.3	0.3	-1.4
Arm predicted mass (left)	1.2	6.3	19.0	1.4	-4.4	-0.7	-2.0