Hub : Genes

DGCR5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3250	0.0490	1.9e-13	0.073	0.146	0.160	0.139	0.135	3.2e-09	2.2e-17	5.2e-19	1.6e-16	4.4e-16
2	TCGA	Brain Lower Grade Glioma	0.0733	0.0345	5.1e-03	0.011	0.008	0.012	NA	0.008	1.9e-02	3.6e-02	1.6e-02	NA	4.0e-02
3	TCGA	Prostate Adenocarcinoma	0.1050	0.0409	4.8e-05	0.036	0.046	0.045	NA	0.041	1.1e-04	1.4e-05	1.5e-05	NA	3.6e-05
4	TCGA	Thyroid Carcinoma	0.0850	0.0320	7.0e-05	0.000	0.035	0.031	NA	0.013	3.4e-01	2.1e-04	5.0e-04	NA	1.9e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.0	1.6	3.1	0.3	1.6	1.8	0.8
Bipolar Disorder or Schizophrenia	0.8	1.9	3.7	0.7	1.3	1.9	1.2
Depressed Affect (Nagel 2018)	0.3	0.5	1.6	0.4	0.4	-0.5	-1.2
Depression (Nagel 2018)	0.5	0.8	1.7	0.5	-1.0	-1.3	-0.5
Intelligence (Savage-Jansen 2018)	0.3	1.1	1.8	-1.3	-1.2	0.5	-0.8
Neuroticism (Nagel 2018)	0.1	0.3	0.9	1.0	0.1	0.1	-0.5
Schizophrenia (2018)	0.3	0.6	1.2	0.8	0.4	1.1	0.8
Schizophrenia vs Biploar Disorder	0.0	0.0	0.1	0.0	0.4	0.0	0.0
Worry (Nagel 2018)	0.3	0.6	0.9	-0.4	-1.0	0.8	-0.8
Alzheimer’s Disease (in mother)	0.5	0.5	1.2	0.9	-0.0	-1.1	-0.3
Alzheimer’s Disease (in father)	2.2	2.4	5.4	-0.1	1.2	2.3	-1.6
Alzheimer’s Disease (including proxy)	0.6	0.8	0.9	0.8	1.0	0.9	-0.9
Crohns Disease (2017)	0.8	1.8	4.9	1.0	0.4	-2.2	-1.1
Irritable Bowel Disease (IBD)	0.4	1.0	2.0	0.8	0.7	-1.4	-0.8
Ulcerative Colitis (UC)	0.4	0.7	2.1	0.5	0.6	-1.4	-0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.1	0.3	1.0	0.3	1.0	-0.1	-0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.5	-0.7	-0.7	-0.0	-0.5
Breast Cancer	0.1	0.3	0.8	0.2	0.4	0.3	-0.9
Ovarian Cancer	1.0	1.3	2.6	1.5	1.6	0.8	0.4
Prostate Cancer	0.9	1.3	3.4	-1.2	-1.9	-0.1	-0.3
Age at First Birth	0.4	0.6	1.4	-0.9	-1.2	-0.4	-0.1
Bipolar Disorder (2011)	0.7	0.7	0.9	-0.8	0.6	-1.0	1.0
Body Mass Index (BMI) (2010)	0.8	1.0	3.2	-0.8	-0.0	1.8	0.6
Coronary Artery Disease (CAD)	3.0	3.6	9.0	-2.0	-0.1	1.2	-3.0
Crohns Disease (2012)	0.4	0.7	1.1	1.1	0.6	-1.1	-0.2
Mean Putamen Volume	0.7	0.8	1.9	-0.2	-0.6	1.4	0.9
Fasting Glucose	0.2	0.3	0.7	0.1	-0.6	-0.8	0.1
HbA1C	0.1	0.2	0.6	0.8	-0.1	0.1	-0.0
HDL Cholesterol	0.2	0.3	0.6	0.4	0.6	0.0	0.7
LDL Cholesterol	0.1	0.2	0.6	0.1	0.8	0.2	-0.5
Lupus	0.6	0.9	2.4	0.6	0.8	-0.6	1.5
Neuroticism (2016)	0.2	0.4	1.1	0.5	0.3	-1.0	0.1
Primary Biliary Cirrhosis	0.2	0.2	0.4	0.7	0.3	-0.4	0.5
Rheumatoid Arthritis	0.5	0.6	1.4	0.4	0.9	1.2	0.3
Schizophrenia (2014)	0.5	1.2	2.7	0.3	-0.1	1.7	1.4
Triglycerides	0.5	0.9	2.1	0.1	-1.2	0.1	1.5
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	-0.4	-0.2	-0.7	-0.4
Ulcerative Colitis	0.9	1.3	4.3	-0.1	0.2	0.9	2.1
Blood Eosinophil Count	0.1	0.7	2.5	-0.5	0.5	0.0	-1.6
Blood Platelet Count	0.6	6.5	20.5	-1.9	-4.5	-1.0	1.0
Blood Red Count	0.0	0.4	1.3	0.4	-0.5	-1.1	-0.1
Blood White Count	0.4	2.9	9.2	-1.4	-3.0	-0.5	0.7
Heel T-Score	1.6	12.6	34.9	-3.2	-5.9	0.0	2.3
BMI	0.3	1.8	5.0	1.2	2.2	-0.5	-0.7
Height	0.2	4.7	11.2	-1.4	-3.3	-1.8	1.6
Waist Hip Ratio (WHR)	0.5	2.4	3.7	-0.5	-1.5	-1.9	1.8
Systolic Blood Pressure	0.3	1.4	4.8	-0.8	-2.2	-0.1	-0.2
Smoking Status	0.2	0.5	1.1	-1.1	-0.6	-0.5	0.4
Allergy or Eczema	0.3	0.8	2.8	-0.5	-0.2	-0.4	-1.7
Cardiovascular Disease	0.2	0.8	1.4	-1.2	-1.1	0.6	0.3
Hypothyroidism (self reported)	0.1	0.3	0.9	-0.4	-0.2	0.3	-0.9
Respiratory disease	0.9	1.9	3.7	1.3	0.5	-1.4	1.9
Type 2 Diabetes (T2D) (2018)	2.2	4.1	7.7	-2.0	-1.6	-1.5	-2.8
Lung FEV1/FVC ratio	0.2	0.9	1.7	-0.6	-0.9	-1.3	-0.9
Lung FVC	0.2	1.0	2.2	0.5	1.5	0.4	1.2
Neuroticism	0.2	0.5	1.8	0.3	-0.2	1.3	-0.3
Chronotype (morning person)	0.2	0.5	1.3	0.4	-1.2	0.7	-0.3
Hair Pigment	0.1	2.1	5.6	0.3	1.3	2.4	-1.1
Tanning	0.1	0.6	2.0	-0.6	0.4	0.1	-1.4
Hand grip strength (left)	0.4	1.1	1.9	-0.7	-1.4	1.0	1.0
Number of treatments/medications taken	1.0	1.9	3.6	-1.4	-1.9	1.1	-0.9
Average weekly spirits intake	3.7	4.6	14.2	-1.8	-1.0	3.8	0.1
Sensitivity / hurt feelings	0.8	1.3	4.0	2.0	1.0	-0.1	0.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.1	-0.3	-1.0	0.7	-0.3
Hearing difficulty/problems: Yes	0.4	0.7	1.1	-0.7	-0.5	1.1	-0.9
Relative age of first facial hair	0.4	0.8	2.7	-1.6	0.5	0.7	-0.1
Other serious medical condition/disability diagnosed by doctor	1.0	1.4	4.1	-0.7	-0.8	2.0	-0.3
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	0.7	0.6	-0.1	-0.5
Ever had hysterectomy (womb removed)	0.3	0.3	1.0	-0.3	0.3	-0.2	-1.0
Systolic blood pressure, automated reading	1.1	3.1	6.3	-2.2	-2.5	0.5	-1.0
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	5.0	-0.4	-1.4	2.2	-0.2
Angina	1.1	1.4	3.4	-1.3	-1.9	0.8	-0.1
Medication for hormone replacement therapy	0.2	0.3	0.8	-0.9	-0.5	0.1	0.1
Vitamin and mineral supplements	0.7	0.9	1.9	-1.4	0.3	0.8	-1.0
Supplements: Zinc	0.2	0.2	0.8	-0.3	0.2	-0.9	0.1
Medication: Co-codamol	1.9	2.2	5.6	2.4	1.4	0.7	0.9
Medication: Metformin	1.4	2.0	2.9	-1.5	-1.7	-1.0	-1.3
Diabetes (father)	1.3	1.6	2.9	-1.7	-1.4	1.2	0.0
Diabetes (mother)	1.2	1.6	3.7	-0.8	-1.9	0.5	1.3
Severe depression (siblings)	0.9	1.0	2.4	-0.8	-0.2	1.5	-1.1
Pack years adult smoking proportion	0.2	0.3	1.0	-0.1	-0.3	-0.0	1.0
Impedance of leg (right)	0.0	0.1	0.1	0.0	-0.2	0.4	-0.2
Leg fat-free mass (left)	0.1	0.5	0.8	-0.7	-0.3	-0.9	0.7
Trunk fat percentage	0.1	0.6	1.5	-0.9	-0.1	0.2	-1.2
Hand grip strength (right)	0.4	1.0	2.2	-0.2	-1.1	0.6	1.5
Townsend deprivation index at recruitment	0.5	0.6	1.0	0.9	-0.2	0.8	1.0
Current tobacco smoking	0.5	0.8	2.5	0.7	-0.2	-0.6	1.6
Average weekly fortified wine intake	1.7	2.0	2.7	-1.6	-1.5	-0.9	-1.6
Maternal smoking around birth	0.3	0.5	0.9	0.8	0.9	-0.2	0.7
Fed-up feelings	0.3	0.6	1.3	0.9	1.1	0.3	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	0.7	-0.1	-0.3	0.7
Relative age voice broke	2.1	3.3	6.4	-2.2	-1.1	0.7	-2.5
Taking other prescription medications	1.5	2.2	5.5	-1.6	-2.4	-0.7	-0.5
Age when periods started (menarche)	0.1	0.3	0.9	0.1	-0.6	0.1	1.0
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	4.0	-1.6	-0.4	0.9	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.1	9.5	-2.3	-3.1	-0.4	1.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.3	0.0	-0.3	-1.0	-1.2
Qualifications: CSEs or equivalent	1.2	1.6	2.7	-1.6	-1.0	0.7	-1.5
Serious illness, injury or assault to yourself	0.3	0.3	1.2	0.1	-1.1	0.3	0.0
High blood pressure	0.7	1.9	4.9	-1.5	-2.2	0.1	-0.7
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.6	-0.3	-0.2	-0.4	-1.6
Multivitamins +/- minerals	0.9	1.2	2.9	1.2	-0.7	-1.7	-0.3
Stomach or abdominal pain in last month	1.6	2.0	3.5	-1.3	-1.4	0.9	-1.9
Supplements: Glucosamine	2.2	2.9	6.6	-1.4	-0.6	1.6	-2.6
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	4.3	-1.6	-0.7	2.1	-0.2
Medication: Atenolol	1.2	1.4	4.8	-0.5	-2.2	-0.6	0.5
Medication: Levothyroxine sodium	0.3	0.5	1.3	1.1	0.7	0.0	-0.3
Sitting height	0.3	1.8	3.4	-0.5	-1.8	-1.4	-1.2
Chronic bronchitis/emphysema (father)	0.5	0.6	1.2	-0.4	0.4	0.9	1.1
High blood pressure (mother)	0.1	0.2	0.3	0.3	-0.3	0.6	-0.3
Body mass index (BMI)	0.1	0.4	1.2	0.4	1.1	-0.3	-0.3
Impedance of leg (left)	0.0	0.2	0.3	0.5	-0.3	0.3	-0.6
Leg predicted mass (left)	0.1	0.4	0.8	-0.7	-0.2	-0.9	0.6
Trunk fat mass	0.1	0.2	0.4	-0.6	-0.3	-0.5	-0.4
Waist circumference	0.1	0.5	1.7	-0.2	0.2	-1.3	0.3
Number of incorrect matches in round	0.4	0.7	1.7	-0.8	-0.4	0.5	1.3
Past tobacco smoking	0.3	0.5	1.3	1.1	-0.1	-0.5	-0.8
Alcohol usually taken with meals	0.7	1.1	2.0	-1.1	-1.1	-0.1	-1.4
Nervous feelings	0.7	1.4	2.4	0.8	1.6	0.5	-1.5
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	3.0	-1.7	-1.4	1.7	-0.0
Hearing difficulty/problems with background noise	0.8	1.3	4.3	-0.1	-0.5	-2.1	-0.8
Hair/balding pattern: Pattern 2	0.3	0.3	0.6	-0.0	-0.3	0.8	-0.8
Had menopause	1.3	1.6	3.8	-1.1	-2.0	0.0	-1.2
Had other major operations	2.1	2.6	9.7	-0.5	0.8	-0.1	-3.1
Forced vital capacity (FVC)	0.1	0.4	0.8	0.3	0.4	-0.8	0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	4.9	-1.8	-2.2	-0.6	0.9
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.3	-0.5	-0.7	0.4	1.8
Qualifications: None of the above	1.0	2.2	5.1	2.3	1.8	0.1	0.6
Financial difficulties in last 2 years	4.5	6.0	11.4	3.0	3.4	-1.7	-0.7
Mouth/teeth dental problems	1.4	2.2	4.9	-1.6	-2.2	-1.0	-0.6
Heart attack	1.2	1.5	3.5	-1.9	-1.5	0.7	0.2
Allergy	0.0	0.1	0.4	-0.1	0.1	0.6	0.0
Pain all over the body in last month	0.2	0.2	0.4	-0.6	0.5	0.2	0.5
Diabetes (self-reported)	1.4	2.2	5.8	-1.5	-2.4	-0.7	-0.4
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	3.7	-1.8	-1.9	-0.0	-1.8
Medication: Ramipril	0.5	0.7	2.5	-0.3	-0.2	-0.1	-1.6
Medication: Simvastatin	0.6	1.0	2.4	-1.5	-0.2	1.1	0.5
Fluid intelligence score	0.2	0.4	0.5	-0.7	-0.6	-0.7	-0.6
Illnesses of siblings	0.4	0.6	1.1	0.5	1.1	0.9	0.4
Neuroticism score	0.4	0.8	1.3	0.9	0.8	1.2	-0.5
Weight	0.1	0.4	1.4	-0.1	-0.1	-1.2	0.1
Impedance of arm (right)	0.2	1.0	2.8	-1.7	-0.7	0.1	-0.9
Arm fat percentage (right)	0.1	0.3	0.9	-0.2	0.9	-0.3	-0.5
Trunk fat-free mass	0.2	1.1	2.5	0.3	-0.1	-1.6	1.3
Hip circumference	0.1	0.6	1.3	-0.2	0.3	-1.1	-1.1
Time employed in main current job	0.3	0.4	1.0	-0.5	0.2	1.0	-0.5
Alcohol intake versus 10 years previously	0.3	0.4	1.4	1.2	0.6	0.0	0.1
Father’s age at death	0.8	1.1	2.6	-0.7	-1.6	-0.9	-0.7
Worrier / anxious feelings	0.5	0.9	2.6	0.8	0.2	1.6	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.1	-0.0	-0.5	0.6	-1.0
Falls in the last year	0.4	0.5	1.3	-1.1	-0.5	-0.0	0.7
Hair/balding pattern: Pattern 3	1.5	2.3	4.7	-2.2	-0.9	1.2	-1.5
Number of live births	0.1	0.2	0.4	0.6	0.0	0.6	0.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.6	0.4	0.1	-0.7	0.7
Pulse rate	0.1	0.1	0.3	0.2	-0.6	-0.1	0.3
Happiness	0.6	0.7	2.4	1.5	0.5	-0.1	0.6
Noisy workplace	1.9	2.4	5.0	0.7	2.2	1.8	1.0
Qualifications: A levels/AS levels or equivalent	3.1	6.8	14.4	-3.2	-3.8	-0.0	-1.7
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.8	0.2	0.8	0.6	-0.9
Mouth/teeth dental problems: Dentures	0.8	1.3	2.9	0.9	1.7	0.1	1.1
Asthma	0.1	0.3	0.6	0.2	-0.0	-0.7	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.8	1.3	0.1	-1.0	0.4
Medication: Cholesterol lowering	0.7	1.1	2.2	-1.5	-1.0	0.4	0.9
Depression (self-reported)	0.4	0.5	1.5	-0.7	-0.3	1.2	0.3
Medication: Lansoprazole	0.3	0.4	0.9	0.4	-1.0	-0.2	0.7
Prospective memory result	0.5	0.6	1.8	0.2	1.3	0.5	-0.5
Lung cancer (father)	0.3	0.3	0.8	0.5	0.4	-0.9	-0.2
Illnesses of mother	0.5	0.6	1.3	0.8	0.6	-1.2	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.5	-0.0	0.3	-0.7	0.4
Pulse wave Arterial Stiffness index	1.8	2.1	5.8	-1.6	-2.4	-0.3	-0.4
Impedance of arm (left)	0.4	1.7	3.9	-2.0	-1.1	0.6	-1.0
Arm fat mass (right)	0.1	0.2	0.4	-0.1	0.6	-0.6	-0.5
Trunk predicted mass	0.2	1.1	2.5	0.2	-0.2	-1.6	1.3
Standing height	0.3	3.1	6.6	-1.3	-2.6	-1.9	0.8
Length of working week for main job	0.3	0.4	1.2	-0.1	0.3	-1.1	-0.3
Exposure to tobacco smoke at home	1.0	1.1	2.0	1.4	1.2	-0.2	0.8
Breastfed as a baby	0.8	1.0	1.5	-0.2	-1.2	-1.1	1.2
Tense / ‘highly strung’	0.8	1.4	2.5	-1.1	-1.6	0.9	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.2	0.5	0.3	1.1	0.9
Hair/balding pattern: Pattern 4	0.5	1.1	2.5	-0.0	-1.1	-1.6	-0.9
Birth weight of first child	0.7	1.2	3.8	1.0	1.9	-0.1	-0.0
Peak expiratory flow (PEF)	0.2	0.5	1.5	-0.0	-0.3	-0.6	1.2
Pulse wave reflection index	1.2	1.5	4.8	-2.2	-1.0	0.3	-0.2
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.6	0.7	0.0	0.8	-0.5
Loud music exposure frequency	0.2	0.2	0.5	-0.3	0.2	0.2	0.7
Qualifications: O levels/GCSEs or equivalent	1.2	1.8	2.1	-1.4	-1.4	-1.1	-1.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	0.4	0.7	0.4	-0.5
Blood clot in the leg (DVT)	0.6	0.8	3.0	0.3	-0.0	-1.7	-0.3
Medication: Paracetamol	0.9	1.5	3.9	2.0	0.9	-0.8	0.8
Headache pain in last month	0.4	0.7	2.5	-0.4	-0.4	0.2	-1.6
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	2.8	1.7	1.6	-0.0	-0.4
Glaucoma (self-reported)	0.5	0.6	0.9	-0.9	-0.2	0.7	-1.0
Gout (self-reported)	0.2	0.2	0.7	0.1	-0.4	-0.3	0.8
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.7	-0.1	0.0	0.2	-0.8
Medication: Amlodipine	0.3	0.4	0.7	-0.5	-0.8	-0.3	-0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	-0.2	-0.8	0.2	0.9
Birth weight	0.4	0.8	2.1	0.8	0.4	0.4	1.4
Chronic bronchitis/emphysema (mother)	1.3	1.5	3.9	-0.1	0.7	2.0	-1.3
High blood pressure (siblings)	0.8	1.1	2.3	0.1	-1.1	-1.5	0.9
Forced vital capacity (FVC), Best measure	0.2	0.6	1.1	0.1	0.7	-1.1	0.7
Body fat percentage	0.1	0.4	1.0	-0.5	0.4	-0.1	-1.0
Leg fat percentage (right)	0.0	0.1	0.4	0.1	0.6	-0.2	-0.3
Arm fat-free mass (right)	0.1	0.5	1.2	0.4	-0.2	-1.1	0.8
Exposure to tobacco smoke outside home	1.1	1.5	3.7	1.9	0.5	-1.2	0.8
Comparative body size at age 10	0.3	0.7	1.3	-0.8	1.1	-1.0	0.0
Number of full brothers	1.3	1.6	5.1	-0.4	0.5	2.3	1.0
Worry too long after embarrassment	0.9	1.6	3.8	1.3	1.9	0.9	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.2	-0.7	-1.1	0.6	-0.7
Wheeze or whistling in the chest in last year	0.1	0.3	0.6	-0.2	-0.8	-0.7	-0.1
Number of children fathered	0.3	0.3	0.4	0.6	0.6	0.5	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.4	-1.6	-1.3	0.2	-0.4
Age at first live birth	0.2	0.3	0.6	-0.7	-0.4	0.8	-0.3
Pulse wave peak to peak time	1.6	1.9	4.9	1.6	2.2	0.1	0.3
Health satisfaction	0.2	0.2	0.6	0.2	-0.0	0.7	-0.5
Shortness of breath walking on level ground	0.7	0.8	2.0	0.5	1.4	0.9	0.5
Qualifications: College or University degree	0.5	1.6	2.9	-1.2	-1.7	-1.1	-0.8
Eye problems/disorders: None of the above	1.1	1.2	3.7	-0.6	-0.7	-0.6	1.9
Mouth/teeth dental problems: Loose teeth	0.9	1.0	2.6	1.2	1.6	0.1	0.1
Emphysema/chronic bronchitis	0.4	0.5	0.9	-0.2	-0.9	-0.4	1.0
Medication for pain relief, constipation, heartburn	0.3	0.6	1.6	-0.7	0.4	0.1	1.3
Neck or shoulder pain in last month	0.3	0.5	1.7	0.3	-1.3	-0.2	0.2
Medication: Blood pressure	0.7	1.3	3.6	-0.9	-1.9	-0.9	0.0
Angina (self-reported)	1.3	1.7	4.5	-1.3	-2.1	0.8	-0.0
Migraine (self-reported)	0.5	0.6	1.3	0.7	0.8	1.1	-0.2
Medication: Ibuprofen	1.2	1.4	3.5	1.9	0.6	-1.1	0.7
Medication: Allopurinol	0.1	0.2	0.5	0.7	0.1	-0.5	-0.2
Medication: Omeprazole	0.9	1.1	2.6	0.1	-0.3	1.6	-1.3
Medication: Seretide 50 evohaler	0.2	0.2	0.7	-0.1	0.5	0.8	0.0
Mean time to correctly identify matches	0.1	0.1	0.2	0.2	0.4	0.2	-0.5
Heart disease (mother)	0.7	0.8	2.8	-0.1	0.7	0.2	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.9	0.6	-0.3	0.4	1.0
Whole body fat mass	0.1	0.3	0.9	-0.1	0.2	-1.0	-0.5
Leg fat mass (right)	0.1	0.3	1.2	0.3	0.3	-1.1	0.2
Arm predicted mass (right)	0.1	0.6	1.0	0.6	-0.1	-1.0	0.9
Pulse rate, automated reading	0.1	0.2	0.5	-0.2	-0.7	-0.3	0.5
Alcohol intake frequency.	0.6	1.3	3.3	-1.2	0.0	1.8	-0.8
Comparative height size at age 10	0.9	5.0	10.2	-2.6	-3.2	-1.8	0.5
Number of full sisters	1.2	1.5	3.1	1.4	1.0	-1.8	-0.1
Suffer from ‘nerves’	0.3	0.5	1.3	-0.1	-0.2	0.8	-1.1
Overall health rating	0.2	0.5	1.6	0.1	-0.1	1.3	-0.7
Chest pain or discomfort	0.1	0.2	0.5	-0.1	-0.4	-0.7	-0.1
Had major operations	0.9	1.1	2.1	-0.8	-1.5	1.2	0.5
Age at last live birth	0.6	0.8	2.3	-0.5	0.3	1.5	-0.9
Family relationship satisfaction	1.1	1.3	4.4	2.1	0.5	-0.6	-0.1
Leg pain on walking	1.0	1.3	4.4	-0.5	0.1	2.1	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	2.4	1.2	1.1	1.1	1.5
Commuting to job workplace: Car/motor vehicle	1.2	1.4	3.6	0.4	0.6	-1.9	-1.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	2.6	-1.6	-1.6	0.1	0.2
Medication: Aspirin	0.9	1.1	2.1	-0.6	-1.4	1.4	-0.2
Supplements: Vitamin C	0.4	0.5	0.7	0.8	-0.0	0.8	0.7
Knee pain experienced in last month	0.6	1.0	1.1	1.1	1.0	-0.9	1.0
Hypertension (Self-reported)	0.9	2.6	5.6	-1.8	-2.4	0.2	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.8	-1.1	-1.7	0.5	-0.8
Illnesses of father: Heart disease	0.4	0.6	1.1	-0.5	0.6	1.1	-0.8
Illnesses of siblings: Diabetes	1.8	2.2	3.0	-1.7	-1.7	-1.2	-1.2
Smoking status: Previous	0.7	1.1	3.6	-1.9	-0.7	0.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.5	-1.6	-0.7	-0.9	-0.5
Whole body fat-free mass	0.1	0.7	1.8	0.0	-0.2	-1.3	1.1
Leg fat-free mass (right)	0.1	0.3	0.9	-0.4	-0.2	-0.9	0.6
Arm fat percentage (left)	0.1	0.2	0.4	-0.5	0.6	0.0	-0.4
Average weekly red wine intake	2.5	3.7	5.8	-1.8	-2.3	0.4	-2.4
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.7	-0.2	-0.2	-1.9	-0.8
Mood swings	0.3	0.5	1.0	1.0	0.9	-0.2	-0.4
Loneliness, isolation	0.1	0.1	0.4	0.7	0.2	-0.1	-0.3
Long-standing illness, disability or infirmity	0.3	0.4	0.6	-0.8	-0.8	0.5	-0.4
Ever had bowel cancer screening	0.2	0.2	0.7	0.8	0.3	-0.0	0.2
Diabetes diagnosed by doctor	1.5	2.5	5.2	-1.5	-2.3	-1.3	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.4	0.6	0.6	-0.4	1.2
Friendships satisfaction	0.3	0.4	0.7	0.7	-0.4	-0.5	-0.9
Qualifications: nursing, teaching	3.6	5.6	15.2	-2.6	-3.9	0.6	0.4
Commuting to job workplace: Walk	1.0	1.1	2.7	-0.8	-1.7	0.7	0.6
Eye problems/disorders: Cataract	0.1	0.2	0.5	0.3	-0.3	0.7	0.2
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	5.5	1.5	2.3	1.4	-0.9
Medication for cholesterol	0.5	0.8	2.0	0.9	0.6	-0.3	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.6	-0.0	0.2	-0.8	0.2
Back pain experienced in last month	0.2	0.4	0.9	0.7	0.1	-0.9	0.3
Mineral and other dietary supplements	0.7	1.0	1.7	-1.3	-0.8	-1.3	0.2
Breast cancer (self-reported)	0.4	0.5	0.9	-0.9	-0.9	-0.4	0.2
Asthma (self-reported)	0.2	0.4	1.3	0.4	-0.0	-0.5	1.1
Osteoporosis (self-reported)	0.7	0.8	1.5	1.2	1.2	0.6	0.2
Osteoarthritis (self-reported)	2.0	2.6	4.1	-2.0	-0.9	2.0	-1.2
Medication: Aspirin	0.7	0.9	2.0	-0.6	-1.1	1.4	0.1
Medication: Gliclazide	1.0	1.1	2.0	-1.3	-1.4	-0.0	-0.8
Illnesses of father: None of the above (group 1)	0.9	1.1	2.0	1.4	1.4	-0.4	0.7
Smoking status: Current	0.4	0.7	2.1	0.7	0.0	-0.3	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.5	0.9	1.2	0.2	-0.5
Whole body water mass	0.1	0.7	1.9	-0.1	-0.2	-1.4	1.0
Leg predicted mass (right)	0.1	0.4	0.9	-0.4	-0.2	-1.0	0.6
Arm fat mass (left)	0.0	0.1	0.2	-0.2	0.5	-0.5	-0.3
Number of self-reported non-cancer illnesses	0.8	1.4	3.9	-1.2	-2.0	0.3	-0.5
Average weekly champagne plus white wine intake	0.2	0.3	0.4	0.1	-0.6	0.6	0.6
Miserableness	0.7	1.3	4.8	-0.1	0.5	-0.2	-2.2
Guilty feelings	1.2	1.8	6.3	2.5	0.9	0.3	0.4
Wears glasses or contact lenses	1.5	1.7	4.0	-0.9	-2.0	-1.4	-0.3
Ever taken oral contraceptive pill	1.8	2.0	6.6	0.5	2.6	-1.0	-0.1
Hearing aid user	0.2	0.2	0.5	-0.0	0.6	0.7	0.2
Mother’s age at death	0.6	0.7	2.1	-0.7	-0.3	0.4	-1.4
Financial situation satisfaction	1.6	2.0	4.2	1.7	0.3	0.8	2.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.6	0.2	1.6	0.1	-0.4
Commuting to job workplace: Public transport	0.7	0.9	1.9	-1.4	-0.4	1.2	0.2
Eye problems/disorders: Glaucoma	1.0	1.1	1.7	-1.2	-0.2	1.3	-1.2
Medication: Blood pressure	0.7	1.4	3.0	-0.8	-1.4	0.2	-1.7
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	0.0	0.1	0.2	0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.4	1.2	-0.2	0.8	0.2
High cholesterol (Self-reported)	1.0	1.8	3.9	-1.0	-0.4	2.0	1.5
Medication: Bendroflumethiazide	0.1	0.1	0.3	-0.2	-0.3	0.6	0.1
Medication: Paracetamol	1.2	1.8	4.3	2.1	0.5	-1.2	1.1
Medication: Lisinopril	0.5	0.7	0.7	-0.9	-0.8	-0.8	-0.8
Medication: Atorvastatin	1.1	1.4	2.9	-0.5	-1.7	0.8	1.3
Illnesses of father: High blood pressure	1.1	1.4	3.9	-1.0	-2.0	0.3	-0.8
Alcohol drinker status: Never	2.3	2.7	4.8	-1.5	-1.0	1.6	-2.2
Ever smoked	0.6	1.1	2.4	-0.7	-0.1	1.1	1.5
Basal metabolic rate	0.1	0.6	1.6	-0.0	-0.1	-1.3	0.9
Leg fat percentage (left)	0.1	0.2	0.3	0.4	0.5	-0.3	-0.6
Arm fat-free mass (left)	0.1	0.4	1.4	0.2	-0.1	-1.2	0.4
Number of operations (self-reported)	2.0	3.0	5.3	-1.2	0.8	2.3	-2.2
Average weekly beer plus cider intake	1.2	1.8	3.7	1.5	1.9	-1.0	0.5
Irritability	0.2	0.3	0.6	-0.2	-0.8	-0.3	-0.6
Risk taking	0.2	0.3	0.6	-0.8	-0.7	0.1	0.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.7	0.3	-0.1	-0.8	-0.1
Fractured/broken bones in last 5 years	0.2	0.3	0.7	0.6	0.4	-0.9	0.1
Age started oral contraceptive pill	0.8	1.0	1.4	-1.2	-0.2	1.0	1.2
Diastolic blood pressure, automated reading	0.7	2.2	6.2	-1.2	-2.5	-0.9	0.5
Ever depressed for a whole week	0.7	0.9	1.8	0.9	0.3	1.3	0.9
Unable to work because of sickness or disability	1.2	1.5	2.5	-1.0	-1.1	1.2	1.6
Commuting to job workplace: Cycle	2.8	3.3	5.0	-2.2	-2.2	1.7	0.8
Myopia	0.4	0.5	1.3	0.9	0.4	-1.1	-0.2
Vascular/heart problems diagnosed by doctor	1.0	2.7	6.4	1.9	2.5	0.0	0.9
Cholesterol lowering medication	0.2	0.3	0.5	-0.5	-0.5	0.7	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.0	-0.4	-1.2	1.4	-1.0
Pain experienced in last month	0.1	0.1	0.3	-0.1	0.2	0.3	-0.5
Supplements: Calcium	2.1	2.3	3.9	1.3	2.0	1.9	0.5
Basal cell carcinoma (self-reported)	2.4	2.8	7.2	1.5	2.7	1.2	0.4
Heart attack/myocardial infarction (self-reported)	1.2	1.5	3.1	-1.8	-1.3	1.1	0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.6	0.0	-0.3	-1.3	-0.4
Heart disease (siblings)	0.4	0.5	1.4	-0.1	0.1	-0.8	-1.2
Alcohol drinker status: Previous	3.2	3.7	7.3	-2.4	-0.6	2.7	1.2
Pack years of smoking	0.0	0.0	0.1	-0.2	-0.2	-0.0	0.3
Impedance of whole body	0.2	0.9	1.4	-1.1	-0.7	0.7	-1.2
Leg fat mass (left)	0.1	0.3	0.9	0.4	0.3	-1.0	-0.1
Arm predicted mass (left)	0.1	0.5	1.6	0.3	-0.2	-1.3	0.5