TWAS hub - MRPL40

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.4390	0.1320	0.00360	-0.011	NA	0.016	NA	-0.011	0.8000	NA	0.1200	NA	0.8800
2	GTEx	Brain Frontal Cortex BA9	0.2575	0.0953	0.00270	0.044	NA	0.035	NA	0.029	0.0260	NA	0.0420	NA	0.0570
3	GTEx	Esophagus Mucosa	0.1600	0.0480	0.00017	0.007	NA	0.016	NA	0.008	0.1000	NA	0.0260	NA	0.0890
4	TCGA	Brain Lower Grade Glioma	0.0401	0.0229	0.00780	0.023	0.013	0.023	NA	0.020	0.0011	0.010	0.0011	NA	0.0022
5	TCGA	Thyroid Carcinoma	0.0760	0.0410	0.00110	0.008	0.009	0.001	NA	0.006	0.0550	0.043	0.2600	NA	0.0790

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Had other major operations	4.2	5.1	11.8	1.2	3.4	1.2	2.2	2.4
Illnesses of father: High blood pressure	3.8	4.7	8.1	-0.6	-1.4	-2.8	-2.4	-2.7
Seen a psychiatrist for nerves, anxiety, tension or depression	3.5	4.6	18.1	4.3	0.6	1.1	-0.2	-1.8
Qualifications: NVQ or HND or HNC or equivalent	3.5	4.2	6.5	-2.5	-2.5	-1.7	-1.9	-1.3
Number of operations (self-reported)	3.5	5.1	10.3	-1.8	3.2	1.9	2.5	1.4
Ever had hysterectomy (womb removed)	3.4	3.8	8.5	0.4	2.9	1.7	2.6	0.7
Ever used hormone-replacement therapy (HRT)	3.3	4.2	7.4	1.2	2.7	0.8	2.5	2.3
Unable to work because of sickness or disability	3.3	4.2	6.2	-2.0	-2.5	-1.9	-2.0	-1.9
Relative age voice broke	3.0	4.7	11.8	-0.6	2.4	1.4	1.9	3.4
Illness, injury, bereavement, stress in last 2 years	3.0	3.7	4.6	1.8	2.0	1.6	2.1	2.0
Schizophrenia (2018)	2.9	6.1	11.1	0.3	-3.3	-1.9	-2.8	-2.8
Body Mass Index (BMI) (2010)	2.9	3.9	5.7	-0.5	-2.4	-1.9	-2.3	-2.1
Relative age of first facial hair	2.9	6.0	15.4	-0.0	2.5	1.3	2.6	3.9
Schizophrenia (2014)	2.7	5.9	11.6	1.3	-3.4	-1.3	-2.8	-2.6
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	7.5	0.4	1.8	-0.4	2.3	2.7
Bipolar Disorder or Schizophrenia	2.4	5.9	11.6	0.5	-3.3	-1.7	-3.4	-2.0
Medication: Lisinopril	2.4	3.1	14.1	-3.7	-1.0	0.2	-0.4	-0.3
HDL Cholesterol	2.3	3.9	8.3	1.9	2.9	0.7	2.2	1.5
Falls in the last year	2.3	3.1	5.2	-1.5	-2.2	-0.5	-1.7	-2.3
Stomach or abdominal pain in last month	2.2	2.8	7.6	-0.8	-1.6	0.6	-1.6	-2.8
Shortness of breath walking on level ground	2.2	2.6	5.7	1.5	1.7	1.0	2.4	1.2
Average weekly spirits intake	2.1	2.6	5.1	-2.1	0.2	2.3	1.8	0.5
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	6.6	-0.5	-2.6	-0.3	-1.8	-1.5
Pulse wave Arterial Stiffness index	2.0	2.3	4.1	0.8	1.7	1.4	2.0	1.5
Breast cancer (self-reported)	2.0	2.4	4.4	1.5	1.2	1.8	2.1	0.8
Mean time to correctly identify matches	1.8	3.5	11.6	0.5	0.9	1.2	1.9	3.4
Number of full sisters	1.8	2.2	5.0	1.4	1.0	-2.2	0.7	1.7
Ever had bowel cancer screening	1.8	2.1	3.1	-1.8	-1.4	0.0	-1.6	-1.7
Fractured/broken bones in last 5 years	1.8	2.4	5.5	0.1	2.3	1.3	1.8	1.2
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	4.2	0.6	1.8	2.1	1.5	0.1
Hearing difficulty/problems with background noise	1.7	2.8	7.7	-0.3	-1.4	-1.1	-1.7	-2.8
Heart attack	1.7	2.2	8.3	-0.9	-0.2	2.9	1.2	-0.7
Medication: Paracetamol	1.7	2.8	4.9	-1.0	-2.2	-2.1	-1.9	-0.4
Pulse wave peak to peak time	1.7	2.0	3.7	-0.6	-1.6	-1.4	-1.9	-1.3
Primary Biliary Cirrhosis	1.6	2.2	4.2	0.7	-1.6	-2.1	-1.9	0.2
High blood pressure (mother)	1.6	2.3	5.9	0.2	-1.3	-1.1	-2.4	-1.5
Fluid intelligence score	1.6	3.2	7.7	-2.0	-1.3	-0.9	-1.4	-2.8
Neck or shoulder pain in last month	1.6	2.2	6.5	-2.6	-1.2	-0.3	-1.1	-1.4
Friendships satisfaction	1.6	2.0	2.7	1.6	-0.6	-1.6	-1.6	-1.4
Eye problems/disorders: Glaucoma	1.6	1.9	4.0	-1.0	-1.0	-2.0	-1.4	-1.2
Medication: Atorvastatin	1.6	2.0	5.8	-2.4	-0.9	-1.8	-0.1	-0.1
Heart attack/myocardial infarction (self-reported)	1.6	2.1	7.1	-1.1	-0.5	2.7	0.8	-1.1
Heel T-Score	1.5	11.5	49.4	7.0	-2.4	0.7	-0.6	-1.3
Hearing difficulty/problems: Yes	1.5	2.3	9.0	-0.5	-0.1	0.3	-1.4	-3.0
Medication for hormone replacement therapy	1.5	1.7	7.1	-0.7	-0.1	-2.7	-0.6	0.8
Alcohol usually taken with meals	1.5	2.4	5.8	1.6	-0.2	1.7	-0.9	-2.4
Prospective memory result	1.5	1.9	3.0	1.4	1.7	-1.1	1.1	1.3
Length of working week for main job	1.5	1.7	3.9	0.2	-1.6	-0.3	-1.3	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	5.2	-2.3	-1.0	-0.3	-1.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	4.2	0.5	-1.8	-2.0	-1.9	-2.0
Osteoarthritis (self-reported)	1.5	2.0	4.1	-2.0	-1.5	-1.1	-1.3	-0.8
Breastfed as a baby	1.4	1.8	3.3	-0.2	-1.5	-1.1	-1.8	-1.5
Loud music exposure frequency	1.4	1.5	2.7	0.4	-1.5	-0.7	-1.6	-1.4
Smoking status: Previous	1.4	2.1	4.5	1.2	1.2	2.1	1.8	0.1
Qualifications: nursing, teaching	1.4	2.1	4.2	-1.1	-1.2	-1.0	-1.6	-2.0
Basal cell carcinoma (self-reported)	1.4	1.6	3.4	-0.7	1.1	1.5	0.9	1.8
Diabetes (father)	1.3	1.6	3.3	-0.2	-1.8	-1.4	-1.6	-0.4
Gout (self-reported)	1.3	1.7	4.0	-1.9	-0.8	-2.0	-0.6	0.1
Average weekly champagne plus white wine intake	1.3	1.8	4.0	2.0	1.1	1.7	0.8	-0.1
Triglycerides	1.2	1.9	3.2	-1.0	-1.8	-1.0	-1.3	-1.5
Sensitivity / hurt feelings	1.2	2.1	7.7	1.0	-0.0	2.8	1.1	-0.7
Serious illness, injury or assault to yourself	1.2	1.5	2.4	-0.8	-1.2	-1.4	-1.0	-1.5
Chronic bronchitis/emphysema (father)	1.2	1.5	2.8	-0.7	-1.7	-0.4	-1.2	-1.5
Noisy workplace	1.2	1.5	5.9	0.6	0.7	-0.7	0.5	2.4
Lung cancer (father)	1.2	1.4	3.8	2.0	0.4	1.3	-0.1	-1.0
Exposure to tobacco smoke at home	1.2	1.4	4.1	0.2	0.3	0.5	1.5	2.0
Medication: Ventolin 100micrograms inhaler	1.2	1.6	3.0	1.7	0.7	-0.2	1.7	1.1
Number of full brothers	1.2	1.5	4.3	-0.4	-2.1	-1.2	-0.9	-1.0
Knee pain experienced in last month	1.2	1.9	6.6	-2.6	-0.9	0.9	-0.3	-1.2
HbA1C	1.1	1.3	2.6	-0.6	-1.5	-1.0	-1.6	-0.3
Pain all over the body in last month	1.1	1.2	2.2	-0.5	-1.5	1.0	-0.7	-1.4
Alcohol intake versus 10 years previously	1.1	1.6	4.3	-1.7	0.2	-2.1	-0.9	-0.1
Glaucoma (self-reported)	1.1	1.3	3.9	-0.8	-0.3	-2.0	-1.0	-1.0
Guilty feelings	1.1	1.7	2.8	-1.2	1.4	1.7	1.5	0.5
Medication: Paracetamol	1.1	1.7	3.7	-0.6	-1.6	-1.9	-1.4	-0.1
Commuting to job workplace: Cycle	1.1	1.4	2.1	-1.0	-1.4	-1.3	-1.1	0.8
Bipolar Disorder (2018)	1.0	1.6	3.8	1.7	-1.0	-0.3	-1.9	0.3
Alzheimer’s Disease (including proxy)	1.0	1.4	2.6	1.5	-1.1	-0.1	-1.6	-1.0
Townsend deprivation index at recruitment	1.0	1.4	3.8	-0.9	-1.9	-0.9	-1.3	-0.2
Medication: Levothyroxine sodium	1.0	1.6	4.5	0.9	0.5	2.1	1.2	-1.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	3.5	-1.9	1.7	-0.4	0.6	0.1
Medication: Lansoprazole	1.0	1.1	3.0	-1.1	-0.9	-0.3	-1.7	-0.7
Tense / ‘highly strung’	1.0	1.7	3.2	1.5	0.8	1.8	1.5	0.2
Overall health rating	1.0	2.2	4.9	-2.2	-1.0	-0.0	-0.6	-2.1
Mood swings	1.0	1.7	3.3	1.8	0.2	1.8	0.9	-1.1
Cholesterol lowering medication	1.0	1.5	3.3	0.7	1.5	1.8	1.2	-0.3
Neuroticism (Nagel 2018)	0.9	2.2	4.2	0.7	1.4	2.0	2.0	-0.0
Fasting Glucose	0.9	1.1	3.5	1.9	-0.2	1.3	0.2	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	5.2	2.3	-1.4	-0.1	-1.1	-1.1
Had menopause	0.9	1.1	2.5	-1.0	0.4	1.2	0.7	1.6
Qualifications: None of the above	0.9	1.8	5.7	0.8	0.6	-0.4	1.5	2.4
Medication: Cholesterol lowering	0.9	1.4	4.5	-2.1	-0.8	-1.2	-0.2	0.4
Hair/balding pattern: Pattern 4	0.9	2.2	4.0	-1.4	2.0	-0.0	1.3	1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	1.7	-1.3	-0.4	-1.3	-0.8	-1.1
Loneliness, isolation	0.9	1.3	3.0	-1.7	-0.2	1.2	0.1	-1.4
Back pain experienced in last month	0.9	1.3	3.7	-1.4	-0.2	1.9	0.5	-0.9
Osteoporosis (self-reported)	0.9	1.1	2.4	-1.6	-0.7	0.7	-0.4	-1.4
Wears glasses or contact lenses	0.9	1.0	3.9	0.2	0.9	2.0	0.6	-0.2
Mother’s age at death	0.9	1.2	2.8	-0.5	1.7	-1.3	-0.1	1.1
Alcohol drinker status: Never	0.9	1.1	4.0	-2.0	0.3	-0.9	-0.2	0.7
Schizophrenia vs Biploar Disorder	0.8	1.0	2.4	-1.1	-0.9	1.6	0.4	-0.8
Reaction Time	0.8	1.5	5.5	0.8	-0.0	0.3	1.2	2.3
Prostate Cancer	0.8	1.2	4.3	-2.1	0.3	-0.6	0.4	-0.9
Chronotype (morning person)	0.8	1.7	7.9	-0.4	-0.1	-2.8	-0.8	-0.3
Qualifications: CSEs or equivalent	0.8	1.1	3.0	-1.7	-0.9	0.0	-1.0	-0.8
Past tobacco smoking	0.8	1.5	5.8	-0.3	-0.2	-2.4	-1.2	0.1
Neuroticism score	0.8	1.6	3.4	1.2	0.8	1.8	1.5	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	5.4	-2.3	-0.5	-0.1	0.2	-1.0
Medication: Allopurinol	0.8	1.0	2.3	0.1	-1.2	-0.6	-1.5	-0.9
Medication: Bendroflumethiazide	0.8	1.2	2.4	-0.1	1.0	0.7	1.4	1.6
Alcohol drinker status: Previous	0.8	0.9	3.7	-1.9	-0.3	0.1	-0.8	0.5
Alzheimer’s Disease (in mother)	0.7	0.8	1.9	0.4	-0.6	1.0	-0.8	-1.4
Blood Platelet Count	0.7	8.3	30.8	-5.5	-0.5	-0.3	-0.9	-3.0
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.4	0.8	1.0	-0.7	1.2	0.8
Angina	0.7	0.9	2.7	-1.6	0.8	0.4	0.6	0.7
Medication: Co-codamol	0.7	0.8	1.9	-0.8	-1.4	-0.6	-1.1	-0.2
Hair/balding pattern: Pattern 2	0.7	0.9	2.5	0.2	1.4	0.4	1.6	0.5
Number of live births	0.7	1.0	1.9	-1.0	1.1	0.3	1.4	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.3	-0.6	-0.5	0.3	-1.0	-1.5
Mouth/teeth dental problems: Dentures	0.7	1.1	3.6	0.4	-1.0	1.9	-0.7	-0.6
Blood clot in the leg (DVT)	0.7	1.0	1.7	0.1	1.0	1.3	1.1	0.9
Medication: Seretide 50 evohaler	0.7	0.8	1.1	1.0	0.3	1.1	1.0	1.0
Chest pain or discomfort	0.7	1.0	3.7	-1.9	-0.1	0.6	-0.2	-1.0
Had major operations	0.7	0.9	1.4	-0.7	1.2	1.2	1.0	-0.1
Supplements: Vitamin C	0.7	0.8	1.8	-1.3	0.7	0.1	1.2	0.5
Vascular/heart problems diagnosed by doctor	0.7	2.0	5.2	-0.1	-1.4	-2.3	-1.7	-0.1
Intelligence (Savage-Jansen 2018)	0.6	2.0	5.7	-2.4	-0.5	-1.1	-0.7	-1.5
Major Depression (MDD)	0.6	0.8	1.5	0.6	-0.9	-1.2	-1.1	-0.2
Lupus	0.6	0.9	2.7	-1.7	-0.9	-0.7	-0.6	0.1
Smoking Status	0.6	1.3	5.3	-0.1	0.3	2.3	0.8	0.8
Supplements: Zinc	0.6	0.6	1.6	-0.8	-0.2	-1.3	-0.6	-0.6
Average weekly fortified wine intake	0.6	0.7	2.0	1.4	0.3	-0.8	-0.2	0.9
Age when periods started (menarche)	0.6	1.5	7.0	-2.6	-0.3	-0.1	0.3	0.5
Number of incorrect matches in round	0.6	1.0	2.6	1.0	0.9	1.6	0.6	0.3
Mouth/teeth dental problems	0.6	0.9	2.6	-0.0	1.0	-1.6	0.7	0.7
Hair/balding pattern: Pattern 3	0.6	0.9	2.6	0.1	-0.7	0.7	-1.6	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.5	-0.9	-1.1	1.2	0.0	-0.3
Illnesses of mother	0.6	0.7	2.4	-0.4	0.3	0.4	1.0	1.5
Birth weight of first child	0.6	1.1	4.1	0.9	-0.1	2.0	0.8	0.2
Peak expiratory flow (PEF)	0.6	1.5	6.3	2.5	-0.9	-0.1	0.2	-0.5
Headache pain in last month	0.6	0.9	1.9	-0.6	-1.0	-0.7	-1.4	-1.0
Qualifications: College or University degree	0.6	1.8	3.2	1.8	1.7	-0.1	-0.0	-1.7
Alcohol intake frequency.	0.6	1.3	2.8	-1.5	-0.1	-1.7	-1.1	-0.7
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.7	-1.2	-0.6	-0.1	0.1	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.0	0.6	-0.0	1.4	0.3	-1.1
Hearing aid user	0.6	0.6	1.7	-0.6	0.8	-1.3	0.7	-0.1
Ever smoked	0.6	1.0	3.7	-0.5	-0.6	1.9	0.9	-0.1
Age started oral contraceptive pill	0.6	0.7	2.2	0.6	0.3	1.5	0.7	0.8
Ever depressed for a whole week	0.6	0.7	1.3	-0.7	0.9	-0.3	1.2	0.9
Pain experienced in last month	0.6	1.0	3.1	1.8	0.9	-0.6	0.3	0.7
Supplements: Calcium	0.6	0.6	1.3	0.7	-0.7	0.3	-1.2	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.1	0.2	0.9	1.0	1.1	0.9
Depressed Affect (Nagel 2018)	0.5	1.1	2.7	-0.4	0.8	1.6	1.2	-0.8
Neuroticism	0.5	1.2	2.2	0.8	0.8	1.5	1.5	-0.4
Number of treatments/medications taken	0.5	0.8	1.5	-1.2	0.7	0.3	1.2	0.7
Vitamin and mineral supplements	0.5	0.6	1.0	0.4	-0.9	0.5	-0.9	-1.0
Pack years adult smoking proportion	0.5	0.8	2.8	-0.2	-0.8	-1.7	0.4	0.7
Taking other prescription medications	0.5	0.7	1.8	-0.5	0.3	1.3	1.0	-0.5
Multivitamins +/- minerals	0.5	0.6	1.4	0.2	1.2	-0.8	0.4	0.9
Hip circumference	0.5	2.0	7.8	0.8	0.3	1.2	0.0	-2.8
Depression (self-reported)	0.5	0.6	2.1	0.8	0.4	1.4	0.1	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	2.6	1.0	-1.6	-1.0	-1.6	-1.2
Pulse wave reflection index	0.5	0.6	1.1	-0.1	1.1	0.6	1.0	0.8
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.0	-0.8	-0.5	-1.4	0.6	0.2
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.1	1.0	0.1	1.3	0.5	-1.5
Age at first live birth	0.5	0.9	1.8	0.6	-0.4	-0.6	-1.3	-1.3
Migraine (self-reported)	0.5	0.6	1.4	0.7	-0.1	-1.2	-0.7	-0.7
Medication: Aspirin	0.5	0.6	2.4	-1.5	0.1	-0.7	-0.1	-0.0
Average weekly red wine intake	0.5	0.7	2.8	0.4	-0.1	1.7	0.2	-0.7
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.1	1.0	-0.5	-0.8	-1.0	0.0
Medication: Aspirin	0.5	0.6	1.0	-1.0	1.0	-0.2	0.7	0.8
Number of self-reported non-cancer illnesses	0.5	0.8	2.0	-1.4	0.9	0.5	0.9	-0.5
Financial situation satisfaction	0.5	0.6	1.7	-1.3	-0.7	-0.5	-0.8	0.2
Medication: Blood pressure	0.5	0.9	2.0	-0.6	1.2	1.4	0.5	-0.5
Average weekly beer plus cider intake	0.5	0.8	1.2	-0.9	0.9	0.1	1.1	1.1
Myopia	0.5	0.7	1.0	-0.6	-0.9	0.7	-1.0	-1.0
Pack years of smoking	0.5	0.7	1.6	0.0	-0.3	-1.2	0.9	1.0
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.1	-1.5	0.1	-1.0	-0.3	-1.4
Neuroticism (2016)	0.4	0.5	1.8	0.9	-0.1	1.3	0.3	-0.0
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.5	-0.9	0.1	0.1	0.1	1.2
Waist Hip Ratio (WHR)	0.4	2.0	4.1	-2.0	-1.6	-1.7	-0.2	-0.6
Respiratory disease	0.4	1.0	3.9	0.8	-0.1	-2.0	0.1	-0.5
Medication: Metformin	0.4	0.5	1.1	-0.3	0.7	0.9	1.0	0.5
Leg fat-free mass (left)	0.4	2.2	9.0	0.0	-1.1	-0.3	-0.9	-3.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.5	-1.2	-0.8	-0.2	-0.0	-0.6
Supplements: Glucosamine	0.4	0.6	1.7	-0.6	0.5	1.3	0.0	-0.7
Medication: Atenolol	0.4	0.5	2.2	-1.5	-0.4	-0.1	0.1	0.3
Sitting height	0.4	2.8	10.7	3.3	0.7	0.1	0.5	-1.6
Leg predicted mass (left)	0.4	2.2	9.2	-0.0	-1.1	-0.3	-0.9	-3.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.6	-1.3	0.4	0.1	1.3	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	3.8	1.9	-0.8	0.3	-0.4	-0.7
Time employed in main current job	0.4	0.5	1.4	-1.2	0.3	0.7	0.7	0.2
Father’s age at death	0.4	0.6	1.1	1.0	1.1	0.8	0.0	0.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	2.3	0.7	-1.5	-0.6	-1.5	-1.4
Pulse rate	0.4	0.6	1.1	1.0	0.2	0.2	1.1	0.9
Happiness	0.4	0.5	1.3	0.8	1.2	-0.4	0.3	0.6
Asthma	0.4	0.8	1.7	0.3	0.8	-1.3	1.3	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.8	1.4	0.8	-0.3	0.5	-0.6
Birth weight	0.4	0.9	2.9	-0.9	-1.7	0.2	0.1	0.8
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.0	-0.9	0.5	-1.0	-0.4	-0.1
High blood pressure (siblings)	0.4	0.6	2.1	0.4	0.4	-0.6	-0.1	1.4
Worry too long after embarrassment	0.4	0.6	1.2	1.1	0.8	0.9	0.5	-0.3
Medication for pain relief, constipation, heartburn	0.4	0.7	3.0	1.7	0.5	-0.0	-0.1	-0.5
Angina (self-reported)	0.4	0.6	2.1	-1.4	0.7	0.4	0.4	0.1
Heart disease (mother)	0.4	0.5	1.7	0.5	0.7	0.5	1.3	0.1
Leg fat mass (right)	0.4	1.5	6.8	-0.1	-0.7	0.4	-0.0	-2.6
Arm predicted mass (right)	0.4	2.2	6.9	1.5	0.3	1.1	0.6	-2.6
Suffer from ‘nerves’	0.4	0.6	1.6	0.4	-1.0	1.3	-0.1	-0.5
Illnesses of siblings: Diabetes	0.4	0.5	1.1	0.9	-0.2	-0.6	-0.6	-1.0
Leg fat-free mass (right)	0.4	1.9	7.7	-0.1	-1.0	-0.1	-0.9	-2.8
Diabetes diagnosed by doctor	0.4	0.7	1.6	-1.3	0.8	-0.4	0.4	0.9
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.1	-1.4	-0.6	-0.5	-0.7	0.2
Medication for cholesterol	0.4	0.6	2.5	0.0	-1.6	-0.3	-0.6	0.0
Asthma (self-reported)	0.4	0.8	2.2	0.1	0.7	-1.5	1.2	0.0
Smoking status: Current	0.4	0.7	1.9	-1.4	-0.6	0.9	-0.3	0.6
Leg predicted mass (right)	0.4	1.9	7.8	-0.1	-1.0	-0.1	-0.9	-2.8
Miserableness	0.4	0.7	1.2	0.5	0.9	1.1	1.1	-0.0
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.0	-0.1	-0.6	-0.2	-1.0	-0.8
Commuting to job workplace: Public transport	0.4	0.4	1.6	-0.0	0.5	1.3	0.2	0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.9	-0.5	-0.9	0.7	0.2	-0.9
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.7	-1.3	-0.0	-0.4	-0.4	-0.3
Depression (Nagel 2018)	0.3	0.4	1.3	-1.1	-0.4	-0.2	-0.3	-0.7
Alzheimer’s Disease (in father)	0.3	0.3	0.9	0.7	0.5	0.1	0.2	1.0
Ulcerative Colitis (UC)	0.3	0.5	1.1	1.0	0.3	0.0	0.8	0.8
Age at First Birth	0.3	0.4	1.2	-1.1	-0.3	0.5	0.2	-0.5
Coronary Artery Disease (CAD)	0.3	0.3	0.5	0.7	0.7	0.7	-0.2	-0.3
LDL Cholesterol	0.3	0.4	1.1	-0.8	0.3	-1.1	-0.0	0.4
Blood White Count	0.3	2.4	4.5	-1.8	-0.1	2.1	0.0	-2.1
Hypothyroidism (self reported)	0.3	0.7	2.1	0.5	-0.4	1.0	0.5	-1.5
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.5	-0.3	1.2	0.8	0.8	0.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.2	-0.6	-0.6	0.3	-0.2	-1.1
Severe depression (siblings)	0.3	0.3	0.7	-0.8	0.5	0.8	0.2	-0.2
Current tobacco smoking	0.3	0.5	1.2	-1.1	-0.6	0.7	-0.3	0.6
Maternal smoking around birth	0.3	0.5	1.2	1.1	0.6	-0.2	-0.1	-0.8
Fed-up feelings	0.3	0.5	1.9	0.1	-0.6	1.4	0.3	-0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.9	-0.4	-0.1	-0.8	-0.0	-0.9
High blood pressure	0.3	0.7	2.1	0.0	0.7	1.4	1.0	0.1
Body mass index (BMI)	0.3	1.3	5.5	-0.7	-0.5	0.4	-0.0	-2.3
Impedance of leg (left)	0.3	1.6	3.6	1.4	0.8	0.7	1.1	1.9
Waist circumference	0.3	1.3	5.2	-0.4	-0.1	0.8	0.7	-2.3
Allergy	0.3	0.7	1.6	0.4	-1.3	0.3	-1.2	-0.5
Diabetes (self-reported)	0.3	0.5	1.2	-1.1	0.3	-0.4	0.6	0.9
Weight	0.3	1.5	6.6	-0.0	-0.3	0.9	0.3	-2.6
Impedance of arm (right)	0.3	1.3	5.0	-1.0	-0.2	-0.5	0.2	2.2
Trunk fat-free mass	0.3	1.5	5.4	1.2	0.1	0.9	0.3	-2.3
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.3	0.3	1.1	-0.5	-0.1	-1.2
Arm fat mass (right)	0.3	1.3	5.1	-0.9	-0.5	0.6	0.1	-2.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.7	1.3	0.3	0.2	-0.5	-0.4
Arm fat-free mass (right)	0.3	1.8	6.4	1.4	0.3	0.5	0.4	-2.5
Exposure to tobacco smoke outside home	0.3	0.4	1.1	-1.0	-0.8	0.6	0.2	-0.1
Number of children fathered	0.3	0.3	0.8	0.9	-0.2	-0.5	0.5	-0.4
Eye problems/disorders: None of the above	0.3	0.3	0.7	0.1	-0.9	0.6	-0.8	0.0
Medication: Ibuprofen	0.3	0.3	0.6	-0.7	-0.8	0.6	0.1	0.2
Whole body fat mass	0.3	1.1	4.7	-0.1	-0.2	0.7	0.4	-2.2
Pulse rate, automated reading	0.3	1.1	2.7	-0.0	-1.6	-0.2	-0.7	-1.5
Illnesses of father: Heart disease	0.3	0.4	0.8	0.5	0.9	0.5	0.7	-0.6
Whole body fat-free mass	0.3	1.5	6.5	0.7	-0.4	0.5	-0.1	-2.6
Long-standing illness, disability or infirmity	0.3	0.5	1.8	-0.2	-0.5	0.7	-0.2	-1.3
Eye problems/disorders: Cataract	0.3	0.4	0.6	0.5	0.2	-0.7	0.7	0.8
Medication: Gliclazide	0.3	0.4	0.9	1.0	-0.4	-0.2	-0.7	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.5	1.2	-0.3	-0.6	-1.0	-0.1
Arm fat mass (left)	0.3	1.2	4.4	-0.8	-0.1	0.9	0.5	-2.1
Ever taken oral contraceptive pill	0.3	0.4	0.7	0.7	0.3	0.7	-0.1	-0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	-0.3	0.1	0.9	0.5	-0.8
High cholesterol (Self-reported)	0.3	0.5	1.5	-1.2	0.5	-0.1	0.4	0.7
Basal metabolic rate	0.3	1.6	7.2	0.5	-0.5	0.4	-0.2	-2.7
Arm fat-free mass (left)	0.3	1.5	5.6	1.1	0.2	0.8	0.5	-2.4
Irritability	0.3	0.5	0.9	0.9	-0.7	1.0	0.1	-0.4
Risk taking	0.3	0.5	1.2	-0.1	-1.1	-0.0	-0.9	-0.7
Heart disease (siblings)	0.3	0.4	1.0	-0.7	-0.3	0.6	-0.3	-1.0
Leg fat mass (left)	0.3	1.2	5.3	-0.1	-0.5	0.7	0.2	-2.3
Arm predicted mass (left)	0.3	1.7	7.0	0.9	-0.3	0.9	0.2	-2.7
Worry (Nagel 2018)	0.2	0.5	1.2	0.7	0.9	0.2	1.1	0.2
Crohns Disease (2017)	0.2	0.4	0.9	-0.1	0.9	-0.9	0.5	-0.2
Crohns Disease (2012)	0.2	0.3	0.4	-0.5	0.6	-0.6	0.6	0.6
Mean Putamen Volume	0.2	0.2	0.4	0.6	0.2	0.3	0.5	0.7
Rheumatoid Arthritis	0.2	0.3	0.5	-0.2	-0.2	-0.6	-0.7	-0.5
Ulcerative Colitis	0.2	0.3	0.7	-0.6	-0.8	-0.7	-0.0	-0.1
Blood Eosinophil Count	0.2	1.4	6.0	2.5	0.0	0.8	-0.4	0.1
BMI	0.2	1.3	6.1	0.0	-0.3	-0.5	-0.3	-2.5
Allergy or Eczema	0.2	0.6	1.9	-1.4	0.9	-0.1	0.1	0.4
Lung FEV1/FVC ratio	0.2	1.1	2.4	1.0	-1.5	-0.3	-1.0	-1.1
Tanning	0.2	2.0	5.2	0.1	2.3	-0.5	1.8	1.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	-0.8	0.2	0.3	0.7	0.3
Systolic blood pressure, automated reading	0.2	0.6	2.5	-0.0	0.4	1.6	0.2	-0.5
Impedance of leg (right)	0.2	0.8	1.8	1.2	0.4	0.0	0.6	1.3
Trunk fat percentage	0.2	0.8	2.4	-1.0	-0.0	0.4	0.6	-1.5
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	-0.6	0.9	-0.7	-0.3	-0.1
Trunk fat mass	0.2	1.0	4.0	-0.6	-0.1	0.6	0.6	-2.0
Financial difficulties in last 2 years	0.2	0.2	0.5	0.2	0.7	0.4	0.7	-0.1
Medication: Ramipril	0.2	0.3	1.1	0.0	0.4	1.0	0.0	-0.0
Medication: Simvastatin	0.2	0.3	0.8	-0.3	0.1	0.9	0.7	-0.4
Arm fat percentage (right)	0.2	0.8	1.9	-1.1	-0.2	0.8	0.5	-1.4
Impedance of arm (left)	0.2	0.9	3.6	-0.6	0.4	-0.3	0.5	1.9
Trunk predicted mass	0.2	1.4	4.7	1.1	0.2	1.0	0.4	-2.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.0	0.2	0.2	1.0	-0.2	-0.3
Medication: Amlodipine	0.2	0.3	1.3	0.1	1.1	-0.0	0.4	-0.0
Forced vital capacity (FVC), Best measure	0.2	0.8	1.4	1.2	-0.7	-0.8	-1.0	-0.6
Body fat percentage	0.2	0.7	2.5	-0.6	0.1	0.6	0.7	-1.6
Leg fat percentage (right)	0.2	0.8	3.2	0.1	0.0	0.7	0.5	-1.8
Wheeze or whistling in the chest in last year	0.2	0.4	1.0	-1.0	-0.1	-0.6	0.7	0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.7	0.6	-0.3	0.3	-0.1	-0.9
Emphysema/chronic bronchitis	0.2	0.3	0.6	0.4	-0.5	0.2	0.5	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	-0.7	-0.3	-0.3	0.3	0.4
Comparative height size at age 10	0.2	1.0	2.8	0.8	0.8	0.9	1.7	-0.2
Age at last live birth	0.2	0.3	0.9	-0.2	0.4	-0.9	-0.4	-0.7
Hypertension (Self-reported)	0.2	0.5	1.6	-0.5	0.6	1.3	0.7	-0.2
Arm fat percentage (left)	0.2	0.8	2.0	-0.9	0.2	0.8	0.8	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	0.5	-0.1	-0.7	-0.1	0.7
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	-0.6	-0.8	0.3	-0.1	0.1
Whole body water mass	0.2	1.4	6.3	0.7	-0.3	0.5	0.0	-2.5
Leg fat percentage (left)	0.2	0.7	2.1	0.0	0.1	1.0	0.7	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	0.6	-0.1	-0.5	-0.6	-0.2
Impedance of whole body	0.2	1.0	4.0	0.1	0.7	-0.2	0.8	2.0
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	0.5	0.6	-0.7	0.6	0.2
Breast Cancer	0.1	0.4	1.5	-0.2	-0.3	0.3	-1.2	0.3
Ovarian Cancer	0.1	0.1	0.3	0.2	0.2	0.5	-0.3	0.4
Bipolar Disorder (2011)	0.1	0.1	0.3	0.3	0.1	0.6	0.0	0.1
Blood Red Count	0.1	1.3	5.1	-0.2	-1.1	-0.1	-0.3	-2.3
Height	0.1	1.1	2.4	0.1	-0.8	1.5	0.2	-1.5
Cardiovascular Disease	0.1	0.3	1.0	-0.2	-0.7	0.2	-0.3	-1.0
Lung FVC	0.1	0.5	1.7	-0.1	-0.3	1.3	-0.8	-0.3
Hand grip strength (left)	0.1	0.4	0.8	-0.1	-0.3	-0.9	-0.5	-0.8
Diabetes (mother)	0.1	0.2	0.5	0.1	0.7	-0.3	0.6	-0.0
Hand grip strength (right)	0.1	0.3	1.0	0.4	-0.2	0.7	-0.0	-1.0
Nervous feelings	0.1	0.2	0.5	0.4	0.7	0.3	0.5	-0.0
Forced vital capacity (FVC)	0.1	0.3	0.6	0.7	-0.4	-0.1	-0.7	-0.6
Illnesses of siblings	0.1	0.2	0.3	0.5	0.3	0.5	0.4	-0.5
Worrier / anxious feelings	0.1	0.1	0.4	0.3	0.5	0.6	-0.0	0.1
Standing height	0.1	0.9	2.0	1.4	0.5	0.9	0.9	-0.6
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	-0.5	0.7	0.2	0.2	0.5
Comparative body size at age 10	0.1	0.2	0.6	0.1	-0.1	0.8	0.5	0.1
Health satisfaction	0.1	0.2	0.3	-0.3	0.5	-0.3	0.5	-0.3
Medication: Blood pressure	0.1	0.2	0.4	-0.6	-0.2	0.2	0.6	0.4
Medication: Omeprazole	0.1	0.1	0.5	0.7	0.2	0.0	-0.2	-0.3
Family relationship satisfaction	0.1	0.1	0.3	-0.1	0.2	-0.0	-0.4	-0.6
Leg pain on walking	0.1	0.1	0.4	0.1	0.1	-0.2	0.6	-0.0
Commuting to job workplace: Walk	0.1	0.1	0.2	0.3	-0.0	0.4	0.3	-0.4
Mineral and other dietary supplements	0.1	0.1	0.3	-0.1	0.1	-0.6	-0.3	0.1
Diastolic blood pressure, automated reading	0.1	0.2	0.4	0.4	0.3	0.6	0.6	0.1
Systolic Blood Pressure	0.0	0.2	0.6	-0.6	0.3	0.8	-0.0	0.0
Hair Pigment	0.0	1.4	4.4	1.1	0.9	2.1	0.3	0.4

Hub : Genes

MRPL40

Models

Trait associations