TWAS hub - SEPT5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.232	0.0620	0.00014	-0.004	NA	0.015	NA	0.008	8.4e-01	NA	3.4e-02	NA	9.1e-02
2	GTEx	Pituitary	0.592	0.1410	0.00490	-0.012	NA	0.035	NA	0.026	9.3e-01	NA	4.6e-02	NA	7.4e-02
3	METSIM	Adipose	0.105	0.0362	0.00048	0.039	0.019	0.070	0.06	0.064	1.4e-06	0.00056	1.3e-10	2.8e-09	7.8e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Heel T-Score	14.0	111.6	269.0	-6.8	-4.5	-16.4
Pain type(s) experienced in last month: Hip pain	7.8	9.8	14.7	2.5	3.8	2.9
Neck or shoulder pain in last month	6.8	9.7	22.7	4.8	2.0	1.5
Heel bone mineral density (BMD) T-score, automated (left)	6.3	14.2	37.8	-1.3	-1.8	-6.2
Heel bone mineral density (BMD) T-score, automated (right)	5.7	13.0	33.3	-1.1	-2.1	-5.8
Number of self-reported non-cancer illnesses	5.0	8.7	14.9	1.9	2.8	3.9
Pain experienced in last month	4.6	7.6	14.4	-3.8	-1.2	-2.7
Hair/balding pattern: Pattern 2	4.0	5.0	13.3	3.7	-0.7	-1.1
Frequency of tiredness / lethargy in last 2 weeks	3.8	6.1	13.4	1.9	1.2	3.7
Hearing difficulty/problems with background noise	3.7	6.0	9.7	2.5	1.3	3.1
Guilty feelings	3.6	5.4	9.3	0.3	2.6	3.0
Medication: Paracetamol	3.5	5.8	8.6	1.7	2.9	2.4
Knee pain experienced in last month	3.3	5.2	10.7	1.2	1.9	3.3
Other serious medical condition/disability diagnosed by doctor	3.2	4.1	9.9	-0.7	1.4	3.1
Hayfever/allergic rhinitis (self-reported)	3.2	4.2	7.9	2.8	0.5	2.1
Depression (Nagel 2018)	3.1	4.6	6.7	1.0	2.6	2.5
Number of treatments/medications taken	3.1	5.5	9.1	1.4	3.0	2.3
Frequency of tenseness / restlessness in last 2 weeks	3.1	4.8	7.1	2.4	1.2	2.7
Commuting to job workplace: Car/motor vehicle	3.1	3.5	8.5	0.4	1.3	2.9
Average weekly spirits intake	3.0	3.8	9.4	-3.1	-1.1	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	3.0	3.8	9.2	1.5	3.0	0.2
Medication for cholesterol	3.0	4.6	7.1	1.8	-1.8	-2.7
Average weekly fortified wine intake	2.8	3.2	5.1	-0.7	-2.0	-2.3
Maternal smoking around birth	2.8	4.0	9.2	-0.2	1.6	3.0
Number of incorrect matches in round	2.8	4.7	12.4	-3.5	-0.9	-0.9
Medication: Atenolol	2.5	3.1	4.8	-1.5	1.5	2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.5	3.9	7.7	2.8	1.9	-0.5
Frequency of depressed mood in last 2 weeks	2.4	3.4	4.4	1.4	2.1	1.9
Taking other prescription medications	2.4	3.7	5.3	1.0	2.2	2.3
Illnesses of siblings	2.4	3.4	3.6	-1.9	-1.8	-1.8
Pulse wave reflection index	2.4	3.0	6.9	-2.6	-1.4	-0.0
Medication for pain relief, constipation, heartburn	2.4	4.1	6.1	-1.9	-1.7	-2.5
Townsend deprivation index at recruitment	2.3	3.3	4.6	2.1	1.2	-2.0
Qualifications: CSEs or equivalent	2.3	3.1	4.1	-2.0	1.6	1.6
High blood pressure (mother)	2.3	3.2	5.9	0.8	2.4	1.7
Pulse wave peak to peak time	2.3	2.6	5.0	2.2	1.3	1.2
Medication: Co-codamol	2.2	2.6	4.7	2.2	1.1	1.4
Hair/balding pattern: Pattern 3	2.2	3.3	6.9	-2.6	0.9	1.5
Pulse wave Arterial Stiffness index	2.1	2.4	4.4	-2.1	-1.2	-1.1
Illnesses of siblings: Diabetes	2.1	2.6	4.4	0.8	1.7	2.1
Medication: Blood pressure	2.1	4.0	5.1	-1.8	1.9	2.3
Medication: Paracetamol	2.1	3.3	5.5	1.3	2.3	1.7
Financial difficulties in last 2 years	2.0	2.7	6.6	2.6	1.2	0.3
Overall health rating	2.0	4.3	11.3	-0.7	1.0	3.4
Deep venous thrombosis (DVT) (self-reported)	2.0	2.5	6.0	1.1	-0.7	2.5
Ulcerative Colitis (UC)	1.9	3.5	8.5	-1.4	0.2	-2.9
Neuroticism (2016)	1.9	2.8	7.0	0.1	1.1	2.6
Hearing difficulty/problems: Yes	1.9	2.9	7.4	-0.9	0.6	2.7
Falls in the last year	1.9	2.6	4.5	1.8	2.1	0.4
Length of working week for main job	1.9	2.1	3.1	1.4	1.8	-1.1
Leg pain on walking	1.9	2.4	6.5	0.4	0.8	2.6
Long-standing illness, disability or infirmity	1.9	2.9	4.6	0.5	1.9	2.1
Back pain experienced in last month	1.9	2.8	3.9	1.4	1.6	2.0
Impedance of leg (left)	1.8	8.5	13.7	-1.8	-2.9	-3.7
Had menopause	1.8	2.3	4.6	0.5	-2.2	-1.4
Blood clot in the leg (DVT)	1.8	2.4	6.0	0.9	-0.5	2.5
Worry too long after embarrassment	1.8	3.0	4.9	1.4	1.5	2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	5.5	0.5	2.4	-0.7
Number of operations (self-reported)	1.8	2.7	4.4	1.6	1.0	2.1
Fractured/broken bones in last 5 years	1.8	2.3	3.2	1.3	1.4	1.8
Coronary Artery Disease (CAD)	1.7	2.0	5.4	-0.7	-0.5	-2.3
Blood Platelet Count	1.7	20.1	22.7	4.0	4.7	4.8
Pain all over the body in last month	1.7	1.9	4.8	2.2	0.3	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	3.2	-1.8	-1.0	1.2
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	6.3	0.9	2.5	1.0
Cholesterol lowering medication	1.7	2.5	3.8	-1.9	0.6	1.9
Bipolar Disorder (2018)	1.6	2.5	5.2	-2.3	1.1	-1.0
Relative age of first facial hair	1.6	3.3	7.3	0.2	-2.7	-1.6
Diabetes (mother)	1.6	2.0	5.8	-0.2	-0.4	2.4
Impedance of leg (right)	1.6	7.9	11.4	-1.7	-3.1	-3.4
Multivitamins +/- minerals	1.6	2.0	3.2	1.8	0.0	1.7
Medication: Cholesterol lowering	1.6	2.5	4.4	1.7	2.1	-0.1
Medication: Lisinopril	1.6	2.1	5.6	-0.7	2.4	0.5
Heart disease (siblings)	1.6	1.9	2.8	1.5	1.7	0.8
HbA1C	1.5	1.7	3.3	0.5	1.2	-1.8
Type 2 Diabetes (T2D) (2018)	1.5	2.8	7.1	1.0	2.7	0.6
Serious illness, injury or assault to yourself	1.5	1.8	4.6	0.4	0.9	2.1
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	2.7	-1.3	-1.6	1.0
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.6	0.8	1.9	1.1
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	4.4	-1.6	-2.1	-0.7
High blood pressure (siblings)	1.5	2.2	4.3	0.6	1.4	2.1
Migraine (self-reported)	1.5	1.8	4.8	2.2	-0.5	0.7
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	4.2	-0.9	-0.6	-2.1
Ever had bowel cancer screening	1.5	1.8	3.0	0.3	1.7	1.5
Ever smoked	1.5	2.7	7.0	1.0	2.6	0.1
Risk taking	1.5	2.2	3.7	0.2	1.9	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	2.8	1.4	1.7	1.0
Mouth/teeth dental problems	1.4	2.1	6.1	0.1	-2.5	-0.5
Exposure to tobacco smoke outside home	1.4	1.9	2.9	1.4	1.7	0.8
Breast cancer (self-reported)	1.4	1.6	3.7	-1.9	-0.7	0.9
Supplements: Glucosamine	1.3	1.6	2.6	1.6	-0.1	1.5
Father’s age at death	1.3	1.8	2.6	-1.0	-1.6	-1.3
Had major operations	1.3	1.5	2.1	1.0	1.2	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.1	0.9	1.7	0.5
Irritability	1.3	2.1	4.8	2.2	0.7	-1.1
Impedance of whole body	1.3	6.6	9.0	-1.7	-3.0	-2.8
Depression (self-reported)	1.2	1.4	2.2	1.5	0.3	-1.4
Glaucoma (self-reported)	1.2	1.4	3.8	0.5	-0.3	2.0
Chest pain or discomfort	1.2	1.7	3.4	0.0	1.9	1.3
Qualifications: nursing, teaching	1.2	1.8	4.3	2.1	-0.1	-1.0
Supplements: Calcium	1.2	1.3	2.5	1.0	-0.7	-1.6
Alzheimer’s Disease (in mother)	1.1	1.3	3.2	-0.8	0.2	-1.8
Rheumatoid Arthritis	1.1	1.5	2.5	-0.6	1.2	1.6
Severe depression (siblings)	1.1	1.2	3.2	0.4	0.5	1.8
Hayfever, allergic rhinitis or eczema	1.1	2.4	6.5	0.6	2.5	0.5
Past tobacco smoking	1.1	2.1	3.4	-0.4	-1.8	1.6
Impedance of arm (right)	1.1	5.3	10.4	-1.0	-3.2	-2.2
Medication: Ventolin 100micrograms inhaler	1.1	1.5	3.0	-0.0	-1.7	-1.2
Leg predicted mass (right)	1.1	5.8	8.7	1.2	2.7	2.9
Miserableness	1.1	1.9	3.4	1.9	1.3	0.7
Financial situation satisfaction	1.1	1.4	2.5	1.6	0.9	1.0
Medication: Bendroflumethiazide	1.1	1.6	2.6	0.1	1.6	-1.5
Diastolic blood pressure, automated reading	1.1	3.4	8.2	-2.9	-1.2	-0.7
Ever depressed for a whole week	1.1	1.3	3.1	0.8	1.8	0.3
Bipolar Disorder or Schizophrenia	1.0	2.3	3.2	-1.8	1.4	-1.4
Schizophrenia vs Biploar Disorder	1.0	1.3	2.1	1.5	-1.0	0.9
Mean Putamen Volume	1.0	1.2	1.8	0.5	-1.2	-1.3
Primary Biliary Cirrhosis	1.0	1.4	2.3	-1.4	-1.5	-0.1
Blood Eosinophil Count	1.0	8.0	23.7	-0.2	4.9	-0.3
Relative age voice broke	1.0	1.6	3.8	-0.8	-1.9	-0.6
Time employed in main current job	1.0	1.1	1.7	-1.2	1.3	-0.3
Breastfed as a baby	1.0	1.3	1.6	0.7	1.3	1.3
Medication: Ibuprofen	1.0	1.1	2.6	1.6	0.7	0.6
Leg fat-free mass (right)	1.0	5.6	8.3	1.1	2.7	2.9
Average weekly red wine intake	1.0	1.5	3.2	-1.8	-0.3	-1.1
Illnesses of father: High blood pressure	1.0	1.2	2.1	-0.2	1.2	1.5
Neuroticism (Nagel 2018)	0.9	2.2	4.7	0.8	1.1	2.2
Breast Cancer	0.9	2.3	5.3	2.3	-0.7	1.0
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.2	1.5	-0.9	0.3
Angina	0.9	1.1	2.9	0.5	0.5	1.7
Leg fat-free mass (left)	0.9	4.9	7.6	0.9	2.5	2.8
Hand grip strength (right)	0.9	2.6	4.7	-1.4	1.0	-2.2
Age when periods started (menarche)	0.9	2.1	4.2	0.3	2.1	1.4
Leg predicted mass (left)	0.9	4.9	7.7	0.9	2.5	2.8
Waist circumference	0.9	3.2	4.1	-1.3	2.0	1.9
Noisy workplace	0.9	1.2	2.6	-1.6	-0.6	-0.7
Impedance of arm (left)	0.9	4.0	6.5	-1.5	-2.5	-1.8
Medication: Amlodipine	0.9	1.2	2.6	-0.3	1.6	1.0
Eye problems/disorders: None of the above	0.9	1.0	1.5	-1.2	-0.4	-1.2
Mood swings	0.9	1.6	4.3	-0.7	2.1	-0.3
Alcohol drinker status: Never	0.9	1.0	1.6	1.0	1.3	0.7
Allergy or Eczema	0.8	2.0	5.7	0.1	2.4	0.6
Cardiovascular Disease	0.8	2.6	6.4	0.6	2.5	1.0
Chronic bronchitis/emphysema (father)	0.8	0.9	2.3	1.5	-0.6	0.4
Had other major operations	0.8	1.0	1.6	-1.3	-1.1	-0.3
Allergy	0.8	1.8	3.5	-0.4	-1.9	-1.3
Medication: Simvastatin	0.8	1.2	3.5	0.0	1.9	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.4	1.2	1.1	0.6
Illnesses of mother	0.8	1.0	2.2	-0.5	-1.5	-0.6
Birth weight of first child	0.8	1.5	2.7	0.0	1.3	-1.7
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	1.6	-1.1	1.3	-0.4
Health satisfaction	0.8	1.0	1.6	-0.8	1.0	1.2
Arm predicted mass (right)	0.8	4.0	6.2	0.9	2.5	2.3
Alcohol intake frequency.	0.8	1.8	4.4	0.8	-0.4	2.1
Smoking status: Previous	0.8	1.1	3.0	0.3	0.5	-1.7
Wears glasses or contact lenses	0.8	0.9	2.6	-0.2	-0.4	1.6
Eye problems/disorders: Glaucoma	0.8	0.9	1.8	-0.6	0.8	1.3
Leg fat percentage (left)	0.8	2.8	8.3	-2.9	0.1	-0.1
Blood White Count	0.7	5.0	7.3	-2.7	2.6	-0.9
Systolic Blood Pressure	0.7	3.5	7.2	-1.1	2.7	1.5
Neuroticism	0.7	1.7	2.5	1.4	0.8	1.6
Systolic blood pressure, automated reading	0.7	1.9	4.8	-2.2	1.0	0.2
Supplements: Zinc	0.7	0.8	1.6	0.8	-0.2	-1.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	2.0	-1.4	0.6	0.4
Exposure to tobacco smoke at home	0.7	0.8	2.1	1.4	0.5	0.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.7	0.7	1.6	0.5
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.7	0.6	0.6	1.3
Body fat percentage	0.7	2.7	8.1	-2.8	0.1	0.4
Leg fat percentage (right)	0.7	2.6	7.7	-2.8	-0.0	0.2
Arm fat-free mass (right)	0.7	3.6	5.5	1.0	2.3	2.1
Medication: Blood pressure	0.7	1.2	2.8	0.8	1.7	0.4
Number of full sisters	0.7	0.9	2.4	-0.2	-0.5	-1.5
Suffer from ‘nerves’	0.7	1.1	2.1	-1.2	-0.0	1.4
Medication: Aspirin	0.7	0.9	1.8	0.2	1.0	1.4
Illnesses of father: Heart disease	0.7	1.0	2.8	0.2	0.2	1.7
Whole body fat-free mass	0.7	4.0	6.0	1.0	2.3	2.4
Diabetes diagnosed by doctor	0.7	1.1	2.2	0.3	1.5	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.8	-0.7	1.3	0.3
Osteoarthritis (self-reported)	0.7	0.9	2.1	0.1	1.5	0.8
Medication: Gliclazide	0.7	0.8	2.3	0.2	1.5	0.2
Smoking status: Current	0.7	1.1	1.8	-1.2	1.3	0.3
Whole body water mass	0.7	4.1	6.1	1.1	2.2	2.5
Basal metabolic rate	0.7	3.8	5.9	0.5	2.3	2.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.9	-0.0	1.4	-0.8
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.0	-1.4	-0.3	-0.0
Smoking Status	0.6	1.5	1.6	-1.1	1.2	-1.3
Lung FEV1/FVC ratio	0.6	3.2	7.7	1.4	-0.0	2.8
Hand grip strength (left)	0.6	1.5	4.2	-0.3	0.6	-2.0
Current tobacco smoking	0.6	1.0	1.8	-1.3	1.0	0.4
High blood pressure	0.6	1.6	3.4	-0.4	1.9	1.1
Medication: Levothyroxine sodium	0.6	1.0	2.5	-0.3	1.6	0.7
Body mass index (BMI)	0.6	2.6	3.4	-1.4	1.6	1.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.7	0.7	1.3	0.1
Heart attack	0.6	0.7	1.8	0.1	1.3	-0.6
Prospective memory result	0.6	0.7	0.9	0.6	-0.9	0.9
Angina (self-reported)	0.6	0.8	2.1	0.4	0.2	1.5
Age at last live birth	0.6	0.9	2.5	-0.4	0.1	1.6
Hypertension (Self-reported)	0.6	1.6	2.9	-0.1	1.7	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.0	1.0	-0.8	0.8
Arm fat percentage (left)	0.6	2.4	5.9	-2.4	0.5	1.0
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.9	1.4	0.2	0.4
Osteoporosis (self-reported)	0.6	0.7	1.4	1.2	-0.6	-0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.5	-0.3	1.2	-0.7
Arm fat-free mass (left)	0.6	2.9	4.0	1.0	1.9	2.0
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.7	-1.3	0.3	0.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.0	0.3	-1.0	-1.0
Basal cell carcinoma (self-reported)	0.6	0.7	0.8	-0.8	0.9	0.9
Arm predicted mass (left)	0.6	3.0	4.2	1.2	2.0	1.9
Depressed Affect (Nagel 2018)	0.5	1.0	2.4	0.4	0.6	1.5
HDL Cholesterol	0.5	0.9	1.5	0.3	-1.2	1.0
Schizophrenia (2014)	0.5	1.1	2.3	-0.7	0.8	-1.5
Sensitivity / hurt feelings	0.5	0.8	1.4	-0.4	1.2	0.9
Vitamin and mineral supplements	0.5	0.6	1.8	-0.2	0.1	-1.4
Pack years adult smoking proportion	0.5	0.7	1.6	-0.7	-0.3	1.3
Trunk fat percentage	0.5	2.2	5.9	-2.4	0.5	0.6
Fed-up feelings	0.5	0.9	2.6	-0.0	-0.3	1.6
Trunk fat mass	0.5	2.1	3.6	-1.9	1.1	1.3
Nervous feelings	0.5	0.9	1.7	-0.6	-1.3	0.8
Qualifications: None of the above	0.5	1.1	2.1	-0.1	-1.4	-1.1
Diabetes (self-reported)	0.5	0.8	2.1	0.1	1.5	0.5
Neuroticism score	0.5	1.0	1.8	0.1	1.1	1.3
Weight	0.5	2.5	4.0	-0.9	1.7	2.0
Trunk fat-free mass	0.5	3.1	4.4	1.0	2.0	2.1
Hip circumference	0.5	2.4	5.0	-0.9	2.2	1.1
Trunk predicted mass	0.5	2.9	4.0	1.0	1.9	2.0
Medication: Omeprazole	0.5	0.6	0.8	0.9	-0.8	-0.6
Heart disease (mother)	0.5	0.6	1.3	1.1	-0.6	-0.2
Whole body fat mass	0.5	1.9	3.7	-1.9	0.9	1.1
Leg fat mass (right)	0.5	1.9	3.1	-1.8	1.0	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.4	1.2	0.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.2	1.4	-0.9	1.1	-1.2
Arm fat mass (left)	0.5	2.1	2.4	-1.6	1.2	1.6
Ever taken oral contraceptive pill	0.5	0.5	0.6	-0.8	0.8	-0.5
Medication: Atorvastatin	0.5	0.6	0.8	0.9	0.9	0.3
Vascular/heart problems diagnosed by doctor	0.5	1.5	2.6	0.4	-1.6	-1.2
Leg fat mass (left)	0.5	2.0	3.4	-1.8	1.1	1.2
Alzheimer’s Disease (including proxy)	0.4	0.6	1.8	0.1	0.3	-1.3
Irritable Bowel Disease (IBD)	0.4	0.8	1.4	-0.9	0.5	-1.2
Prostate Cancer	0.4	0.5	0.9	-0.1	-0.8	-0.9
Crohns Disease (2012)	0.4	0.6	1.9	-0.2	-1.4	-0.1
LDL Cholesterol	0.4	0.6	1.0	0.8	1.0	0.5
BMI	0.4	2.3	4.3	-0.7	1.5	2.1
Fluid intelligence score	0.4	0.8	1.8	-0.0	1.3	-0.8
Arm fat percentage (right)	0.4	1.6	4.5	-2.1	0.2	0.6
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.3	0.7	1.5	1.1
Arm fat mass (right)	0.4	1.7	2.2	-1.4	1.0	1.5
Loud music exposure frequency	0.4	0.5	0.7	0.5	0.9	-0.7
Birth weight	0.4	0.8	1.6	0.9	-0.1	-1.2
Comparative body size at age 10	0.4	1.0	1.5	-1.2	0.8	-0.9
Number of full brothers	0.4	0.6	0.9	0.9	0.9	0.1
Wheeze or whistling in the chest in last year	0.4	0.6	1.5	1.2	0.6	0.1
Shortness of breath walking on level ground	0.4	0.5	0.6	-0.7	0.6	0.7
Pulse rate, automated reading	0.4	1.2	2.9	-0.5	-0.7	-1.7
Friendships satisfaction	0.4	0.5	1.1	0.6	1.0	0.5
Hearing aid user	0.4	0.4	0.9	-0.6	-0.9	0.3
Commuting to job workplace: Public transport	0.4	0.5	1.1	-0.6	0.1	-1.0
High cholesterol (Self-reported)	0.4	0.8	1.1	0.5	1.0	1.1
Alcohol drinker status: Previous	0.4	0.4	1.2	0.2	1.1	0.2
Pack years of smoking	0.4	0.5	1.0	-0.7	-0.5	1.0
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.9	1.4	0.3	0.9
Schizophrenia (2018)	0.3	0.7	0.9	-0.6	0.9	-1.0
Worry (Nagel 2018)	0.3	0.5	1.5	0.3	-0.1	1.2
Alzheimer’s Disease (in father)	0.3	0.3	0.7	0.8	-0.0	0.4
Age at First Birth	0.3	0.4	0.7	-0.1	0.8	0.7
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	0.0	0.7	-0.9
Ulcerative Colitis	0.3	0.5	0.9	-0.9	0.2	-0.7
Blood Red Count	0.3	3.1	8.6	-0.8	-2.9	0.1
Tanning	0.3	3.7	8.9	-3.0	1.4	0.5
Medication for hormone replacement therapy	0.3	0.3	0.5	0.5	0.3	0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.8	-0.6	0.9	-0.1
Stomach or abdominal pain in last month	0.3	0.3	0.7	0.2	0.5	0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.9	0.0	1.0	0.1
Medication: Ramipril	0.3	0.4	1.1	-0.4	0.1	-1.1
Worrier / anxious feelings	0.3	0.5	0.7	-0.8	0.9	-0.2
Pulse rate	0.3	0.4	0.9	-0.6	-0.1	-1.0
Mouth/teeth dental problems: Dentures	0.3	0.5	1.4	-0.2	0.3	-1.2
Number of children fathered	0.3	0.3	0.9	-0.1	0.2	0.9
Emphysema/chronic bronchitis	0.3	0.3	0.3	-0.6	0.5	0.6
Medication: Allopurinol	0.3	0.4	0.7	0.6	0.9	0.0
Commuting to job workplace: Walk	0.3	0.3	0.5	0.7	-0.5	-0.4
Mineral and other dietary supplements	0.3	0.4	0.9	-0.3	-0.9	0.4
Medication: Aspirin	0.3	0.3	0.8	-0.2	0.5	0.9
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.5	-0.6	0.7	0.5
Unable to work because of sickness or disability	0.3	0.4	0.6	0.7	-0.3	0.8
Myopia	0.3	0.4	0.9	1.0	-0.2	-0.3
Crohns Disease (2017)	0.2	0.4	0.7	-0.7	0.1	0.8
Height	0.2	3.7	5.1	2.3	1.7	1.8
Waist Hip Ratio (WHR)	0.2	0.9	1.3	0.3	1.1	1.1
Respiratory disease	0.2	0.5	1.5	0.1	0.1	1.2
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	-0.1	-0.6	0.6
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	-0.4	-0.7	0.3
Medication: Metformin	0.2	0.2	0.4	0.5	0.1	0.7
Diabetes (father)	0.2	0.2	0.4	-0.5	-0.6	0.0
Forced vital capacity (FVC)	0.2	0.6	1.8	-0.2	1.4	-0.2
Alcohol intake versus 10 years previously	0.2	0.4	0.8	-0.9	-0.5	0.2
Number of live births	0.2	0.2	0.7	-0.1	-0.8	0.2
Happiness	0.2	0.2	0.3	0.5	-0.1	0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.3	0.9	0.9	0.2	-0.3
Headache pain in last month	0.2	0.3	0.5	-0.6	-0.3	-0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.7	-0.8	0.5	0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	-0.4	-0.4	0.6
Family relationship satisfaction	0.2	0.2	0.5	0.7	0.1	-0.3
Supplements: Vitamin C	0.2	0.3	0.6	0.4	-0.1	0.8
Loneliness, isolation	0.2	0.3	0.7	0.1	0.8	0.3
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	-0.3	0.7	-0.1
Average weekly champagne plus white wine intake	0.2	0.3	0.5	0.1	0.7	0.5
Mother’s age at death	0.2	0.3	0.6	-0.2	0.3	-0.8
Age started oral contraceptive pill	0.2	0.3	0.9	-0.9	-0.1	0.1
Commuting to job workplace: Cycle	0.2	0.3	0.5	0.7	-0.5	-0.4
Reaction Time	0.1	0.1	0.3	-0.6	-0.2	-0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	0.6	-0.1	0.4
Ovarian Cancer	0.1	0.1	0.1	-0.3	-0.3	0.1
Fasting Glucose	0.1	0.1	0.1	0.4	-0.3	0.2
Lupus	0.1	0.1	0.2	-0.0	-0.5	0.4
Triglycerides	0.1	0.1	0.2	-0.5	0.3	-0.3
Lung FVC	0.1	0.5	0.9	-0.5	0.9	-0.7
Chronotype (morning person)	0.1	0.3	0.6	-0.8	-0.2	0.3
Hair Pigment	0.1	3.0	5.7	1.5	-2.4	-1.0
Sitting height	0.1	0.7	1.9	1.4	0.0	0.5
Alcohol usually taken with meals	0.1	0.1	0.2	-0.4	0.1	0.4
Lung cancer (father)	0.1	0.1	0.3	0.0	0.5	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.6	0.4	0.8	0.2
Standing height	0.1	0.6	1.3	1.2	0.2	0.6
Tense / ‘highly strung’	0.1	0.2	0.5	-0.1	-0.7	0.1
Hair/balding pattern: Pattern 4	0.1	0.2	0.2	-0.5	-0.5	0.4
Peak expiratory flow (PEF)	0.1	0.3	0.4	0.2	0.5	0.7
Gout (self-reported)	0.1	0.2	0.5	0.3	0.7	0.0
Forced vital capacity (FVC), Best measure	0.1	0.2	0.4	0.1	0.6	-0.5
Age at first live birth	0.1	0.1	0.2	-0.2	-0.2	0.5
Qualifications: College or University degree	0.1	0.3	0.7	0.3	0.8	-0.4
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.5	-0.3	-0.1
Mean time to correctly identify matches	0.1	0.3	0.7	-0.9	-0.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.3	0.6	0.2	-0.5
Average weekly beer plus cider intake	0.1	0.1	0.2	0.3	0.4	-0.3
Major Depression (MDD)	0.0	0.1	0.2	0.4	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Hypothyroidism (self reported)	0.0	0.1	0.2	-0.4	0.3	0.1
Asthma	0.0	0.1	0.2	0.1	-0.0	0.4
Medication: Lansoprazole	0.0	0.0	0.1	-0.3	0.1	0.1
Comparative height size at age 10	0.0	0.2	0.7	-0.0	-0.0	-0.8
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.4	0.1	0.1
Asthma (self-reported)	0.0	0.0	0.1	0.2	-0.2	0.2

Hub : Genes

SEPT5

Models

Trait associations