Best TWAS P=4e-10 · Best GWAS P=1.15e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | GTEx | Thyroid | PTPN13 | 0.41 | 0.31 | lasso | 6 | 0.30 | 3.2e-23 | 6.0 | 6.2 | 4.0e-10 | 0.99 | 0.01 | 0.99 | TRUE |
| 4 | GTEx | Esophagus Muscularis | AFF1 | 0.11 | 0.09 | lasso | 2 | 0.10 | 1.3e-06 | 5.7 | -6.1 | 1.3e-09 | -0.32 | 0.05 | 0.94 | TRUE |
| 1 | GTEx | Adrenal Gland | PTPN13 | 0.15 | 0.05 | lasso | 3 | 0.06 | 2.8e-03 | 6.0 | -5.9 | 3.8e-09 | -0.82 | 0.03 | 0.78 | FALSE |
| 2 | GTEx | Artery Aorta | MAPK10 | 0.15 | 0.17 | enet | 16 | 0.17 | 1.4e-09 | 6.1 | -5.8 | 5.8e-09 | -0.96 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Brain Caudate basal ganglia | C4orf36 | 0.25 | 0.01 | enet | 25 | 0.09 | 1.6e-03 | -2.9 | 5.2 | 2.3e-07 | 0.44 | 0.04 | 0.48 | FALSE |
| 5 | GTEx | Nerve Tibial | MAPK10 | 0.08 | 0.01 | enet | 17 | 0.03 | 1.7e-03 | 6.0 | -5.1 | 3.1e-07 | -0.71 | 0.02 | 0.95 | FALSE |