Hub : Genes

IRF7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Pancreas 0.2830 0.1020 3.1e-03 0.025 NA -0.002 NA 0.020 3.0e-02 NA 4.1e-01 NA 4.7e-02
2 GTEx Thyroid 0.1050 0.0460 8.6e-03 0.011 NA 0.000 NA 0.002 4.4e-02 NA 2.9e-01 NA 2.3e-01
3 METSIM Adipose 0.0706 0.0269 8.7e-04 0.021 0.017 0.026 0.028 0.019 3.2e-04 1.0e-03 7.9e-05 4.3e-05 6.8e-04
4 YFS Blood 0.0515 0.0131 1.8e-09 0.041 0.033 0.045 0.041 0.050 3.1e-13 6.4e-11 1.3e-14 2.2e-13 4.5e-16
5 TCGA Breast Invasive Carcinoma 0.0340 0.0162 3.0e-06 0.027 0.029 0.024 NA 0.021 2.5e-06 9.9e-07 9.1e-06 NA 3.5e-05
6 TCGA Cervical Squamous Cell Carcinoma 0.1890 0.0890 7.4e-03 -0.005 0.002 0.007 NA 0.003 6.5e-01 2.5e-01 1.4e-01 NA 2.1e-01
7 TCGA Kidney Renal Clear Cell Carcinoma 0.0524 0.0235 1.0e-05 0.051 0.041 0.031 NA 0.037 2.0e-06 1.9e-05 1.8e-04 NA 4.8e-05
8 TCGA Kidney Renal Papillary Cell Carcinoma 0.1500 0.0620 4.3e-05 0.008 0.058 0.070 NA 0.037 1.1e-01 3.1e-04 8.2e-05 NA 3.5e-03
9 TCGA Brain Lower Grade Glioma 0.1022 0.0415 2.6e-08 0.053 0.075 0.063 NA 0.063 1.1e-06 7.6e-09 1.2e-07 NA 1.1e-07
10 TCGA Lung Adenocarcinoma 0.0325 0.0195 3.6e-03 0.006 0.021 0.038 NA 0.022 5.8e-02 1.5e-03 2.5e-05 NA 1.1e-03
11 TCGA Lung Squamous Cell Carcinoma 0.0460 0.0253 2.6e-04 0.031 0.039 0.017 NA 0.025 1.6e-04 2.5e-05 4.4e-03 NA 6.8e-04
12 TCGA Pheochromocytoma and Paraganglioma 0.1700 0.0720 2.1e-04 0.068 0.069 0.090 NA 0.106 1.1e-03 1.0e-03 1.9e-04 NA 5.3e-05
13 TCGA Prostate Adenocarcinoma 0.0598 0.0261 2.8e-06 0.043 0.055 0.059 NA 0.051 2.7e-05 1.8e-06 8.8e-07 NA 4.8e-06
14 TCGA Skin Cutaneous Melanoma 0.2370 0.1160 3.2e-03 0.017 0.139 0.077 NA 0.069 1.1e-01 1.5e-04 4.4e-03 NA 6.5e-03
15 TCGA Thyroid Carcinoma 0.0750 0.0280 1.8e-09 0.100 0.086 0.091 NA 0.091 5.8e-10 1.0e-08 3.9e-09 NA 3.5e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bipolar Disorder (2018) 0.3 0.5 1.8 0.0 0.1 -1.1 -1.2 -0.1 -1.2 0.5 -1.4 0.1 0.1 -0.0 -0.9 0.1 0.8 0.5
Bipolar Disorder or Schizophrenia 0.2 0.4 1.7 0.0 -0.7 -0.1 1.3 -0.0 0.5 0.5 0.9 0.1 1.2 0.3 0.9 -0.4 -0.7 -0.2
Depressed Affect (Nagel 2018) 0.2 0.5 3.1 -0.1 -1.8 0.5 0.5 -0.6 -0.1 0.1 -0.4 -0.4 -0.7 -0.5 -0.1 -0.8 1.0 -0.7
Depression (Nagel 2018) 0.4 0.6 1.7 1.1 -1.3 -0.5 0.4 -0.6 -0.0 -0.1 -0.6 -0.1 -1.1 -0.5 -0.4 -0.9 1.0 -1.0
Intelligence (Savage-Jansen 2018) 0.6 1.9 3.9 -1.5 -1.7 1.5 -0.5 -1.8 0.9 -1.6 -0.7 -1.7 -1.0 -1.5 -0.1 -1.4 0.8 -2.0
Neuroticism (Nagel 2018) 0.1 0.2 0.9 0.6 -0.8 0.9 0.7 0.3 -0.1 0.7 -0.1 0.1 0.4 0.0 0.2 0.4 0.4 -0.0
Schizophrenia (2018) 1.0 2.0 6.9 -2.3 -1.0 0.3 2.6 0.2 1.6 0.3 2.4 0.0 1.4 0.4 1.9 -0.3 -1.5 -0.6
Schizophrenia vs Biploar Disorder 1.3 1.7 5.3 0.0 0.3 0.0 2.3 1.2 0.4 1.1 2.2 1.1 1.2 1.4 2.2 0.7 -1.4 0.8
Worry (Nagel 2018) 0.4 0.9 2.3 1.5 0.4 0.1 1.1 1.2 0.5 1.0 0.7 0.7 1.4 0.8 0.8 1.3 -0.2 0.5
Alzheimer’s Disease (in mother) 0.5 0.6 3.8 -0.4 -2.0 0.1 0.8 -0.5 0.6 -0.5 0.3 -0.3 0.0 -0.3 0.6 -0.7 0.6 -1.2
Alzheimer’s Disease (in father) 0.4 0.5 1.5 -0.4 -0.4 0.2 0.9 0.6 -1.0 1.2 0.4 0.8 0.2 0.8 0.6 0.8 -0.2 0.7
Alzheimer’s Disease (including proxy) 0.3 0.5 3.0 -0.5 -1.7 0.4 1.2 -0.1 -0.1 0.3 0.6 0.4 0.0 0.3 0.9 -0.1 0.1 -0.6
Crohns Disease (2017) 0.8 1.7 5.9 -0.4 -1.9 -1.1 -0.6 -2.2 -0.2 -1.5 0.2 -1.4 -1.0 -1.4 -0.6 -2.4 -0.2 -1.4
Irritable Bowel Disease (IBD) 0.5 1.1 4.4 0.4 -1.2 -0.5 -0.8 -1.7 -1.3 -0.6 0.3 -1.0 -0.5 -1.1 -0.6 -2.1 -1.1 -0.7
Ulcerative Colitis (UC) 0.2 0.4 2.3 1.0 0.5 -0.2 -0.3 0.0 -1.4 0.6 0.3 0.1 0.3 -0.1 -0.2 -0.4 -1.5 0.6
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.3 0.5 1.7 0.6 -1.2 0.2 -1.0 -0.4 -0.6 0.6 -1.3 -1.0 -0.4 -0.1 -0.7 0.1 0.9 0.1
Verbal and Numeric Reasoning (VNR) 0.3 0.8 2.5 -1.3 -1.0 1.6 -0.2 -1.0 -0.4 -0.9 -0.2 -0.8 -1.2 -0.8 0.2 -0.7 -0.1 -1.3
Breast Cancer 0.6 1.6 18.1 -0.3 -0.6 4.3 1.0 0.3 0.9 0.2 0.2 -0.4 0.5 -0.5 0.1 1.1 0.5 -0.7
Ovarian Cancer 0.4 0.6 3.7 1.1 -0.1 -1.9 0.6 0.0 1.2 0.4 0.5 -0.2 0.7 -0.0 0.5 -0.0 -0.6 0.0
Prostate Cancer 0.7 1.0 5.6 1.5 -0.5 0.6 -0.0 0.1 -2.4 1.4 0.4 0.2 1.5 0.4 0.4 -0.0 -1.0 0.9
Age at First Birth 1.8 2.6 6.8 -0.7 1.6 -2.2 1.4 1.4 -0.5 0.9 2.3 0.9 2.2 1.3 1.6 1.4 -2.6 1.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.8 7.8 -1.6 -2.8 0.3 -1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.3 0.5 1.4 0.0 -0.2 -1.1 -0.7 -1.0 -0.5 -0.8 0.5 -0.8 0.0 -0.9 -0.5 -1.2 -0.9 -0.3
Mean Putamen Volume 1.0 1.1 3.8 1.6 -0.2 0.5 1.5 0.6 -0.4 0.5 2.0 0.5 0.7 0.8 1.6 0.4 -1.7 0.4
Fasting Glucose 1.5 1.8 7.4 -2.7 -1.5 -0.1 -0.6 -1.5 -0.6 -1.4 -0.3 -2.0 -0.4 -1.7 -0.2 -1.4 -0.5 -1.6
HbA1C 4.1 4.6 7.9 -2.6 -1.4 0.7 -2.5 -2.7 -0.4 -1.8 -2.8 -2.1 -1.9 -2.4 -2.7 -2.2 1.9 -2.3
HDL Cholesterol 0.7 1.2 14.7 3.8 1.8 -0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
LDL Cholesterol 0.1 0.2 1.5 -0.7 -0.5 -0.5 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Lupus 12.5 18.9 42.9 -1.5 -5.9 0.0 -1.4 -5.5 4.6 -5.1 -2.6 -5.7 -4.0 -5.0 -2.3 -4.8 4.0 -6.5
Neuroticism (2016) 2.7 3.9 7.4 1.0 2.3 0.8 2.0 2.7 0.1 2.2 1.8 2.5 1.5 2.7 1.5 2.4 -1.4 2.3
Primary Biliary Cirrhosis 4.0 5.7 12.6 -1.5 -3.5 -1.0 -1.4 -2.7 1.3 -2.1 -2.4 -3.1 -2.6 -2.8 -1.6 -2.3 2.5 -3.0
Rheumatoid Arthritis 0.8 1.2 2.7 -1.1 -0.5 -1.1 -0.9 -0.8 1.6 -0.7 -1.0 -1.6 0.6 -1.5 -1.3 -0.1 1.2 -0.8
Schizophrenia (2014) 0.8 1.8 4.5 -1.5 -0.0 0.0 2.1 0.9 -0.4 1.0 1.9 1.1 1.9 1.1 2.1 0.4 -2.0 0.5
Triglycerides 0.3 0.5 5.1 -2.2 -0.9 0.5 -1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Type 2 Diabetes (T2D) (2012) 0.1 0.2 2.3 0.0 0.0 0.0 -1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 1.8 2.6 12.5 0.0 0.8 -0.4 0.8 0.8 -3.3 1.2 2.1 1.2 0.3 1.2 1.7 0.1 -3.5 1.2
Blood Eosinophil Count 0.2 1.7 6.9 -1.9 -2.6 -0.3 1.0 -1.3 0.2 -0.9 -0.3 -0.3 -1.6 -0.9 0.3 -2.1 0.8 -1.8
Blood Platelet Count 0.2 2.6 8.2 1.2 -1.6 1.6 -2.9 -1.3 -1.9 -0.7 -2.2 -2.0 -0.1 -1.9 -1.8 -1.3 0.6 -0.6
Blood Red Count 0.1 1.0 3.6 0.7 1.9 0.4 -1.8 0.4 -1.5 -0.4 -1.2 -0.5 -0.1 -0.8 -1.3 0.7 -0.4 0.6
Blood White Count 0.3 2.4 14.7 0.2 -0.9 3.8 -1.4 -1.1 1.2 -1.2 -2.0 -1.9 -1.2 -1.2 -0.7 -0.3 1.2 -1.3
Heel T-Score 0.1 0.7 2.3 -1.2 0.5 1.1 -0.8 -0.4 -0.4 -1.3 -0.4 -0.3 -1.5 -0.7 -0.8 -0.5 0.3 -0.6
BMI 0.4 2.1 7.0 -0.9 -2.1 0.9 -1.1 -2.4 -0.6 -0.7 -1.1 -1.6 -1.5 -1.5 -1.0 -2.6 -0.0 -1.2
Height 0.3 5.7 10.9 -0.5 -2.7 -1.5 -0.8 -3.0 2.8 -2.5 -2.0 -3.3 -2.9 -2.6 -0.8 -2.4 2.0 -3.3
Waist Hip Ratio (WHR) 0.4 1.6 6.2 -0.6 -2.5 1.8 0.9 -1.0 1.3 -1.2 0.1 -1.1 -0.3 -1.3 0.5 -0.8 0.7 -2.2
Systolic Blood Pressure 0.4 1.9 4.0 2.0 1.5 0.8 1.4 1.9 0.7 0.9 1.6 1.0 2.0 1.4 0.9 1.6 -0.6 1.2
Smoking Status 0.6 1.4 4.6 -0.3 2.1 0.9 0.1 1.8 1.3 0.7 0.0 1.1 1.3 0.8 0.1 2.1 0.4 1.2
Allergy or Eczema 1.4 3.8 12.1 -0.1 -1.1 1.7 3.5 1.4 -0.3 2.7 2.2 2.1 1.6 2.5 3.0 0.4 -1.1 1.6
Cardiovascular Disease 0.5 1.7 8.5 -0.6 0.6 2.9 2.2 1.1 1.8 0.7 1.2 0.5 1.6 0.4 1.0 0.9 -0.6 0.2
Hypothyroidism (self reported) 7.4 17.1 34.7 -3.3 -4.7 -2.1 -2.5 -5.3 1.5 -5.5 -2.9 -4.6 -3.6 -5.4 -3.2 -5.1 3.2 -5.9
Respiratory disease 1.2 2.6 6.1 -0.0 2.5 0.8 1.2 2.0 0.3 1.5 1.2 2.2 0.4 2.2 1.8 1.3 -2.0 2.1
Type 2 Diabetes (T2D) (2018) 0.1 0.2 1.9 0.0 -0.4 1.4 0.4 0.3 0.3 0.3 0.0 0.2 0.5 0.6 0.6 -0.1 0.3 0.3
Lung FEV1/FVC ratio 0.1 0.7 4.2 -1.5 -0.3 -0.5 -0.0 0.3 -2.1 0.8 0.1 1.1 -0.0 0.7 -0.3 -0.2 -0.0 0.8
Lung FVC 0.4 1.8 6.4 -2.5 -0.9 -0.7 -0.4 -1.2 1.5 -1.5 -1.0 -0.5 -1.2 -1.3 -1.4 -1.2 1.9 -1.4
Neuroticism 0.3 0.7 2.8 1.0 -1.3 0.9 1.7 0.6 -0.0 1.0 0.7 0.8 0.4 0.9 1.1 0.3 0.3 -0.0
Chronotype (morning person) 0.8 1.9 3.3 0.2 -0.4 1.5 -1.5 -1.6 1.3 -1.8 -1.6 -1.8 -1.8 -1.5 -1.1 -1.1 0.8 -1.4
Hair Pigment 0.0 1.3 2.3 -0.6 -0.8 -1.3 -0.7 -1.1 1.1 -1.2 -1.1 -1.4 0.0 -1.4 -1.5 -0.9 1.3 -1.3
Tanning 0.0 0.4 3.0 1.7 0.9 0.2 -0.5 0.7 0.4 0.5 -0.4 0.1 -0.3 -0.1 -0.4 0.7 -0.3 0.7
Hand grip strength (left) 1.1 2.8 6.5 -1.0 -1.4 -2.0 -1.5 -1.9 -1.3 -1.6 -1.2 -1.9 -1.4 -2.6 -1.8 -2.0 0.4 -2.1
Number of treatments/medications taken 1.2 2.1 4.4 -1.8 -2.0 2.1 -0.0 -1.7 2.1 -0.9 -1.0 -1.4 -1.5 -1.1 -0.3 -1.3 1.1 -1.5
Average weekly spirits intake 0.7 0.8 1.8 1.3 -1.1 1.1 -0.5 -0.9 1.4 -0.5 -0.5 -1.1 -0.1 -0.8 -0.6 -0.6 1.3 -0.6
Sensitivity / hurt feelings 0.2 0.3 1.0 -0.3 -0.5 0.7 -0.7 0.0 -0.1 0.1 -1.0 -0.4 0.4 -0.4 -0.8 0.6 0.9 -0.0
Frequency of depressed mood in last 2 weeks 0.4 0.6 2.0 0.6 -1.4 -0.8 0.2 -0.7 0.7 0.3 -0.9 -0.1 -1.0 -0.1 -0.6 -0.9 1.2 -0.5
Hearing difficulty/problems: Yes 1.8 2.7 7.9 0.5 -2.8 -2.5 -0.9 -2.1 -1.3 -1.2 -0.5 -2.0 -1.7 -1.6 -0.5 -2.2 0.2 -1.7
Relative age of first facial hair 0.2 0.3 1.3 0.5 -0.3 -1.1 -0.3 -0.1 0.4 -0.3 -0.7 -0.4 -0.1 -0.5 -0.7 -0.0 1.1 -0.6
Other serious medical condition/disability diagnosed by doctor 1.3 1.6 5.5 -1.5 0.5 -1.5 1.8 0.6 -0.7 0.6 2.3 0.9 0.8 1.1 1.6 0.3 -2.0 0.7
Ever used hormone-replacement therapy (HRT) 0.4 0.6 2.2 -0.1 -1.5 1.4 1.1 -0.4 0.5 0.1 0.2 -0.6 -0.7 -0.0 1.1 -0.6 0.0 -0.5
Ever had hysterectomy (womb removed) 1.1 1.2 4.4 2.1 0.1 1.4 1.3 0.9 1.6 1.5 -0.1 0.7 0.9 0.9 0.4 1.0 0.5 0.9
Systolic blood pressure, automated reading 0.2 0.6 4.0 2.0 -0.6 0.4 -0.0 -0.6 1.2 0.0 0.0 -0.4 -0.2 -0.1 -0.9 -0.7 1.0 -0.1
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 2.3 0.9 0.7 0.7 0.5 0.9 -0.2 0.8 1.0 0.5 1.5 0.9 0.3 1.0 -0.9 0.9
Angina 1.3 1.8 5.2 -2.2 -0.3 0.4 -1.2 -1.1 1.2 -1.7 -0.9 -2.3 0.9 -1.9 -1.1 -0.1 0.4 -1.5
Medication for hormone replacement therapy 0.4 0.5 2.0 -0.8 -1.4 1.2 0.7 -0.2 0.1 0.5 0.3 0.2 -0.9 0.5 0.8 -0.8 0.3 -0.0
Vitamin and mineral supplements 0.5 0.7 2.2 -0.9 1.5 0.2 0.2 0.9 -0.3 0.7 0.4 0.8 0.3 1.0 0.8 1.0 -0.8 1.2
Supplements: Zinc 0.7 0.8 2.2 0.9 -0.0 0.7 1.3 1.2 -0.5 0.9 0.6 1.5 1.0 1.0 0.8 0.9 0.3 0.4
Medication: Co-codamol 0.8 0.9 5.0 -0.7 -0.7 0.7 2.2 0.6 0.5 0.8 1.0 1.2 -0.6 1.0 1.5 -0.0 -0.4 -0.1
Medication: Metformin 0.3 0.4 2.4 -0.3 -0.1 1.6 -0.0 0.1 1.4 -0.2 -0.2 -0.2 0.3 0.2 0.0 0.1 0.8 0.0
Diabetes (father) 1.5 1.9 5.7 0.8 0.3 0.4 -2.2 -1.4 1.3 -1.4 -2.4 -0.9 -1.6 -1.1 -1.9 -0.8 1.4 -0.8
Diabetes (mother) 0.8 1.0 4.4 -2.1 -0.3 0.7 1.0 -0.6 -0.8 -1.1 0.9 0.4 -0.8 -0.3 0.6 -1.7 -0.8 -1.3
Severe depression (siblings) 0.3 0.3 0.9 0.9 0.0 -1.0 0.3 0.3 -0.1 0.6 0.4 0.5 0.7 0.6 0.4 -0.1 -0.2 0.6
Pack years adult smoking proportion 0.4 0.7 2.8 -0.9 0.6 -0.2 -1.7 -0.3 0.1 -0.3 -1.4 -0.9 -0.5 -0.5 -1.2 0.5 0.9 0.2
Impedance of leg (right) 0.2 0.8 4.1 -0.1 0.6 -0.7 1.0 0.8 -1.1 -0.5 2.0 0.5 0.8 0.2 1.0 0.2 -1.6 0.2
Leg fat-free mass (left) 0.5 2.6 5.9 -0.5 -1.8 -0.9 -1.6 -2.2 1.3 -0.8 -2.4 -2.0 -1.9 -1.5 -1.3 -1.8 1.6 -1.5
Trunk fat percentage 0.2 0.7 2.7 -0.4 -1.6 0.8 1.4 -0.7 0.4 0.6 0.5 0.1 -1.1 0.2 1.1 -1.2 -0.3 -0.2
Hand grip strength (right) 1.3 3.6 8.1 -0.4 -1.0 -1.5 -1.9 -2.2 0.1 -2.4 -1.8 -2.3 -2.2 -2.9 -2.1 -2.0 1.0 -2.4
Townsend deprivation index at recruitment 0.8 1.1 2.9 -1.0 1.0 0.1 0.7 1.0 0.1 1.4 0.9 1.4 1.1 1.7 0.7 1.2 -0.6 1.5
Current tobacco smoking 1.7 2.8 7.3 -1.2 2.7 -0.6 0.8 2.6 0.3 1.4 1.1 1.8 2.3 1.5 0.7 2.7 -0.8 1.9
Average weekly fortified wine intake 0.9 1.1 5.4 1.3 0.1 0.0 1.6 0.8 -0.5 0.4 2.3 0.6 0.9 0.7 1.4 0.1 -1.4 0.3
Maternal smoking around birth 1.5 2.2 5.2 1.4 0.0 0.8 2.3 1.3 0.1 1.9 1.8 1.8 0.3 2.3 2.0 1.2 -0.8 1.3
Fed-up feelings 0.2 0.4 1.2 0.3 -0.8 0.9 1.0 0.3 0.9 0.7 -0.4 0.2 0.4 0.1 0.0 0.3 1.1 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 1.1 0.8 -0.5 -0.6 0.2 -0.2 1.1 0.2 -0.2 -0.3 -0.0 -0.1 -0.3 -0.1 0.6 -0.2
Relative age voice broke 2.8 4.2 8.8 0.9 2.3 -0.3 2.1 2.4 -0.1 2.2 2.0 1.7 3.0 2.2 2.2 2.6 -2.2 2.2
Taking other prescription medications 0.9 1.4 6.7 -1.8 -1.6 1.2 1.6 -0.8 2.6 -0.3 0.5 -0.5 -0.1 -0.1 1.0 -0.6 0.5 -1.1
Age when periods started (menarche) 0.2 0.5 1.0 1.0 1.0 -0.4 -0.4 0.9 -0.9 0.4 0.2 0.8 0.8 0.6 -0.2 0.6 -0.1 0.8
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 5.2 2.3 -0.9 -0.3 0.7 0.0 1.3 0.4 -0.3 -0.3 0.5 -0.3 0.4 0.3 0.3 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 3.0 -1.1 -1.6 -0.0 -0.2 -1.3 1.6 -1.2 -1.0 -1.2 -1.0 -1.1 -0.6 -1.0 1.4 -1.7
Tinnitus: Yes, but not now, but have in the past 0.9 0.9 3.6 0.9 -0.3 0.8 1.3 0.5 -0.7 0.4 1.9 0.2 -0.4 0.8 1.7 -0.0 -1.5 0.4
Qualifications: CSEs or equivalent 0.6 0.8 2.9 0.0 -0.5 -0.7 -0.6 -1.1 0.8 -1.7 -0.6 -0.6 -1.1 -0.8 -0.6 -1.0 0.8 -1.5
Serious illness, injury or assault to yourself 0.3 0.4 1.1 0.3 -0.4 -0.6 -0.2 -0.9 -0.6 -0.6 0.4 -0.6 0.6 -0.5 0.1 -0.9 -1.0 -0.6
High blood pressure 0.3 0.9 7.3 1.1 0.3 2.7 1.2 0.6 1.1 0.8 0.6 0.1 0.9 0.2 0.2 0.5 -0.4 0.3
Hayfever, allergic rhinitis or eczema 1.3 2.8 7.4 0.4 -0.3 1.0 2.7 1.6 -0.1 2.4 1.8 2.2 1.3 2.5 2.4 0.6 -0.8 1.8
Multivitamins +/- minerals 0.8 1.0 2.0 0.7 -1.0 0.2 -0.5 -0.9 1.4 -0.8 -1.3 -0.9 -1.0 -1.1 -1.1 -0.8 1.4 -1.2
Stomach or abdominal pain in last month 1.2 1.4 5.6 0.8 0.1 -0.3 1.9 1.2 -0.3 1.1 2.0 0.9 2.4 0.6 1.1 0.7 -1.3 0.6
Supplements: Glucosamine 2.0 2.6 4.7 -0.2 -1.7 -1.0 -1.5 -1.9 0.7 -1.5 -2.1 -1.3 -1.3 -1.7 -2.1 -1.8 2.2 -2.0
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 2.0 0.3 -1.4 -0.0 1.1 -0.2 -0.0 0.4 0.3 0.0 0.1 -0.3 0.3 -0.5 0.4 -0.3
Medication: Atenolol 2.0 2.5 6.2 -0.4 -1.5 0.8 -1.7 -1.8 0.7 -1.5 -1.9 -2.5 -1.0 -2.3 -1.7 -1.1 1.8 -1.6
Medication: Levothyroxine sodium 5.8 9.8 18.5 -2.1 -4.3 -1.0 -1.4 -4.1 1.6 -3.6 -2.7 -3.1 -3.2 -3.4 -2.0 -3.9 3.7 -4.3
Sitting height 2.0 14.4 24.8 -2.1 -4.0 -2.8 -2.8 -5.0 2.2 -4.4 -3.3 -4.9 -3.5 -4.8 -3.0 -4.4 3.1 -4.9
Chronic bronchitis/emphysema (father) 2.8 3.3 11.0 -0.1 -2.3 0.0 -1.4 -1.9 1.0 -1.7 -2.2 -1.5 -1.8 -1.6 -1.9 -1.5 3.3 -2.1
High blood pressure (mother) 0.4 0.6 2.1 0.7 -1.2 -0.9 0.9 -0.8 -0.7 -0.0 0.6 -0.3 -0.8 -0.0 0.8 -1.4 -0.6 -0.6
Body mass index (BMI) 0.2 0.7 3.6 -0.4 -1.9 0.8 0.2 -1.3 -0.0 0.5 -0.6 -0.5 -1.2 -0.4 -0.0 -1.5 0.2 -0.5
Impedance of leg (left) 0.2 0.8 4.7 -0.5 0.2 -0.1 1.2 0.6 -0.8 -0.6 2.2 0.4 0.6 0.2 1.2 -0.0 -1.7 0.0
Leg predicted mass (left) 0.5 2.7 5.9 -0.5 -1.9 -0.8 -1.6 -2.3 1.2 -0.8 -2.4 -2.1 -1.9 -1.6 -1.3 -1.9 1.5 -1.5
Trunk fat mass 0.2 1.0 4.5 -0.8 -2.1 0.2 0.7 -1.4 0.7 0.2 -0.3 -0.7 -1.6 -0.5 0.4 -1.7 0.2 -0.7
Waist circumference 0.3 0.9 6.1 0.1 -2.5 0.7 1.0 -1.3 0.1 0.5 0.1 -0.4 -0.8 -0.3 0.7 -1.6 -0.2 -0.7
Number of incorrect matches in round 0.5 0.8 2.9 0.6 -1.7 0.3 -0.0 -1.1 0.6 -0.6 -1.0 -0.8 -1.4 -0.7 -0.0 -1.2 0.9 -1.0
Past tobacco smoking 0.6 1.2 3.2 -0.4 0.1 0.5 1.3 0.7 -1.7 0.6 1.7 1.2 0.3 1.2 1.7 0.3 -1.8 0.7
Alcohol usually taken with meals 0.8 1.4 3.2 1.0 -0.7 -0.1 -1.8 -1.5 -0.8 -0.7 -1.2 -1.5 -1.2 -1.5 -1.3 -1.6 -0.4 -0.5
Nervous feelings 0.2 0.3 1.7 0.4 -0.1 -0.2 -0.1 0.3 1.3 0.2 -1.0 -0.1 0.7 -0.1 -0.3 0.7 1.1 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.2 0.8 -0.1 0.9 0.3 -0.4 0.5 0.3 0.4 -0.6 0.5 0.3 0.3 -0.5 0.8 0.2 0.6
Hearing difficulty/problems with background noise 0.1 0.1 0.6 -0.8 -0.4 -0.4 -0.2 -0.0 0.6 -0.2 -0.5 -0.3 0.0 -0.3 -0.1 -0.1 0.4 -0.1
Hair/balding pattern: Pattern 2 0.4 0.5 2.9 -1.7 -0.5 0.3 -0.2 -0.7 1.1 -0.7 -0.1 -0.7 -0.4 -0.7 -0.4 -0.2 0.4 -0.5
Had menopause 0.9 1.1 2.2 0.0 0.7 -0.1 1.5 1.0 1.2 1.3 1.3 0.2 1.3 1.0 1.3 1.2 -1.1 1.1
Had other major operations 1.1 1.4 6.0 -2.4 -1.6 0.3 -0.1 -1.3 1.2 -0.5 -0.9 -1.2 -1.3 -0.9 -0.4 -1.0 1.4 -1.2
Forced vital capacity (FVC) 0.9 3.3 4.8 -1.4 -1.4 -2.2 -1.4 -2.0 1.8 -2.2 -1.4 -1.8 -1.9 -1.9 -2.0 -1.6 2.1 -1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.5 2.6 -1.1 -1.5 1.6 -0.3 -1.5 1.5 -1.3 -1.1 -1.4 -1.2 -1.2 -0.3 -1.0 1.0 -1.6
Ever unenthusiastic/disinterested for a whole week 3.9 4.8 8.9 -1.3 -1.2 -0.7 -2.1 -2.3 1.8 -2.6 -2.5 -2.7 -1.1 -2.9 -3.0 -1.5 2.5 -2.8
Qualifications: None of the above 0.1 0.3 1.1 -0.5 0.4 1.0 -0.6 -0.0 -0.2 -0.8 0.0 -0.7 -0.1 -0.6 -0.4 0.0 -0.7 -0.2
Financial difficulties in last 2 years 0.1 0.2 0.8 -0.8 0.0 0.2 -0.2 0.1 -0.9 0.4 -0.4 0.1 0.6 0.1 -0.0 -0.2 -0.3 0.1
Mouth/teeth dental problems 0.3 0.5 1.8 0.8 -0.2 1.1 0.9 0.1 1.4 -0.3 0.2 0.2 -0.8 0.5 0.8 0.1 1.0 -0.4
Heart attack 0.7 1.0 2.8 -0.7 1.0 0.9 -1.7 -0.7 -0.4 -1.4 -0.8 -1.1 -0.5 -1.2 -1.5 -0.1 -0.2 -0.7
Allergy 0.8 1.8 4.8 -0.2 0.1 -0.6 -1.9 -1.4 -0.7 -2.2 -0.9 -1.7 -1.2 -2.0 -1.6 -0.9 0.0 -1.6
Pain all over the body in last month 0.4 0.4 2.7 -0.4 -1.6 -0.8 0.8 -0.5 -0.3 0.5 -0.0 0.5 -0.1 0.1 0.4 -1.1 0.1 -0.1
Diabetes (self-reported) 0.3 0.5 3.9 -0.4 0.0 2.0 0.4 0.5 0.4 0.3 0.5 0.1 0.9 0.6 0.6 0.7 0.1 0.6
Hayfever/allergic rhinitis (self-reported) 3.4 4.5 10.4 0.8 0.7 0.1 3.2 2.4 -0.9 2.6 2.6 2.5 2.5 2.6 2.7 1.7 -1.7 1.9
Medication: Ramipril 0.7 0.9 5.3 0.3 -0.3 0.1 0.5 0.3 2.1 -0.2 -1.1 0.1 -0.6 0.2 -0.2 0.5 2.3 -0.8
Medication: Simvastatin 0.4 0.6 4.7 -0.9 -0.5 2.2 0.7 -0.1 0.7 -0.3 -0.1 -0.2 0.7 -0.3 0.6 0.2 0.4 -0.8
Fluid intelligence score 0.8 1.6 3.7 -1.8 -1.4 1.2 -0.6 -1.5 -0.1 -1.8 -0.6 -1.3 -1.4 -1.5 -0.1 -1.5 0.5 -1.9
Illnesses of siblings 0.6 0.9 5.2 0.5 -0.9 -1.4 -0.6 -0.9 -2.3 -0.2 0.8 -0.6 -0.1 -0.4 -0.2 -1.2 -1.0 -0.0
Neuroticism score 0.3 0.6 4.0 0.5 -2.0 -0.1 0.3 -0.7 0.7 -0.0 -0.7 -0.9 0.3 -0.7 -0.3 -0.4 1.0 -0.9
Weight 0.4 2.0 6.6 -0.6 -2.6 -0.4 -0.4 -2.2 1.0 -0.4 -1.4 -1.6 -1.9 -1.2 -0.5 -2.1 0.9 -1.4
Impedance of arm (right) 0.4 1.7 3.3 1.2 1.8 -0.9 1.1 1.8 -0.3 0.5 1.6 1.3 1.5 1.2 1.3 1.6 -1.1 1.1
Arm fat percentage (right) 0.1 0.5 2.2 -0.3 -1.5 0.5 0.9 -0.6 0.0 0.9 0.0 0.1 -0.9 0.2 0.6 -1.0 -0.1 -0.0
Trunk fat-free mass 0.9 5.1 10.7 -0.8 -3.1 -1.7 -2.1 -3.3 0.7 -1.6 -2.5 -3.0 -2.3 -2.4 -1.8 -3.0 1.5 -2.3
Hip circumference 0.1 0.5 1.7 0.8 -1.3 -0.1 0.5 -1.0 0.2 0.7 -0.2 -0.4 -0.9 0.2 0.5 -1.1 -0.2 0.0
Time employed in main current job 1.1 1.3 7.4 -0.8 -0.6 -0.2 0.7 0.0 2.7 -0.3 -1.3 -0.1 -0.9 -0.2 -0.4 0.4 2.6 -1.0
Alcohol intake versus 10 years previously 1.1 1.7 5.0 1.2 2.2 0.1 0.2 1.8 0.2 1.4 0.7 0.7 1.9 1.0 -0.1 2.2 -0.8 1.6
Father’s age at death 1.8 2.5 5.6 -1.2 0.7 -0.3 1.4 1.3 -2.4 1.2 2.2 1.3 1.0 1.6 2.3 0.8 -2.4 1.6
Worrier / anxious feelings 0.4 0.7 4.0 2.0 1.0 -0.0 -0.4 0.9 0.1 0.8 -0.5 0.2 1.3 0.1 -0.6 1.1 -0.2 0.9
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.2 1.1 -0.1 -0.6 1.0 0.4 -0.0 -0.6 1.1 -0.1 0.4 0.1 0.5 0.2 -0.0 -0.2 0.4
Falls in the last year 0.6 0.8 1.9 -1.0 -1.4 -1.2 0.9 -0.4 -0.9 0.7 0.8 0.6 -0.9 1.0 0.9 -1.0 -0.5 0.2
Hair/balding pattern: Pattern 3 0.4 0.6 1.9 0.3 0.6 0.6 0.3 1.0 -0.0 0.6 -0.1 1.3 -1.0 1.4 0.8 0.5 0.6 0.9
Number of live births 1.1 1.5 3.9 0.5 1.7 -1.2 1.2 1.5 0.9 1.4 1.0 1.1 2.0 0.7 0.2 1.6 -0.8 1.4
Forced expiratory volume in 1-second (FEV1) 0.7 2.2 5.4 -1.2 -1.4 -2.3 -1.0 -1.6 0.7 -1.4 -1.2 -1.0 -1.8 -1.3 -1.8 -1.6 1.8 -1.3
Pulse rate 0.2 0.3 0.7 0.6 -0.7 0.4 0.8 0.0 -0.5 0.4 0.7 0.5 0.4 0.6 0.5 -0.5 -0.7 0.2
Happiness 0.3 0.4 1.7 0.4 -1.1 -0.8 0.3 -0.7 1.3 0.1 0.2 -0.7 0.2 -0.5 -0.6 -0.6 0.3 -0.4
Noisy workplace 0.7 0.8 2.8 0.1 0.4 0.9 -1.1 -0.4 1.2 -0.2 -1.3 -0.0 -1.4 -0.2 -1.4 0.0 1.7 0.2
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.6 0.2 0.8 1.3 0.7 0.9 0.5 0.2 0.2 0.7 0.3 0.4 0.2 0.9 0.6 0.2
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 3.1 1.4 1.6 -0.9 0.9 1.3 1.5 0.8 1.0 1.3 0.1 1.8 1.1 1.1 -0.6 1.3
Mouth/teeth dental problems: Dentures 0.3 0.5 2.1 -1.4 0.2 0.0 -1.0 -0.5 -0.3 -0.3 -0.0 -0.3 0.5 -0.8 -1.0 -0.6 -0.9 0.2
Asthma 1.1 2.1 3.8 -0.1 1.1 1.2 1.9 1.7 1.1 1.6 1.4 1.9 0.5 2.0 1.9 1.2 -1.3 1.6
Medication: Ibuprofen (e.g. Nurofen) 6.7 8.5 16.9 0.6 -3.8 -1.0 -3.1 -4.1 0.6 -2.3 -3.4 -3.5 -3.9 -2.7 -2.4 -3.4 2.9 -2.7
Medication: Cholesterol lowering 0.5 0.8 4.7 -2.2 0.8 1.5 0.7 0.5 1.4 0.1 0.2 0.6 0.5 0.3 0.2 0.8 0.3 0.1
Depression (self-reported) 0.8 1.0 4.6 -0.2 1.6 -0.7 -0.3 0.8 2.1 0.1 -0.4 0.0 1.3 -0.3 -1.2 1.5 0.7 0.5
Medication: Lansoprazole 1.5 1.8 7.1 -2.7 -2.2 0.5 0.4 -1.9 0.8 -0.6 -0.2 -1.4 -0.6 -1.3 -0.2 -1.7 -0.0 -1.6
Prospective memory result 0.8 1.0 3.8 -0.5 1.1 0.9 0.6 0.8 -0.3 0.7 1.5 0.4 1.9 0.9 0.5 0.6 -1.5 1.0
Lung cancer (father) 3.3 3.8 7.3 1.2 2.4 1.5 1.7 2.6 0.3 2.7 1.7 2.1 0.4 2.5 1.6 2.7 -1.2 2.5
Illnesses of mother 0.6 0.8 2.0 0.8 0.6 1.2 -1.3 0.4 0.4 0.1 -1.1 -0.9 1.3 -0.5 -0.7 1.4 0.2 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.8 3.8 0.3 -0.7 -2.0 -0.6 -0.8 0.3 -0.4 -0.8 -0.0 -1.4 -0.3 -1.2 -0.9 1.3 -0.3
Pulse wave Arterial Stiffness index 0.7 0.8 3.6 1.9 -1.3 0.8 1.1 -0.3 0.4 -0.2 0.5 0.0 -1.5 0.5 0.9 -0.3 0.5 -0.4
Impedance of arm (left) 0.7 3.0 6.2 1.4 2.3 -0.6 1.5 2.5 -0.5 1.2 2.0 2.0 1.6 1.9 1.7 2.2 -1.3 1.8
Arm fat mass (right) 0.2 1.0 4.4 -0.4 -2.1 0.3 0.1 -1.5 0.5 0.2 -0.8 -0.8 -1.5 -0.6 -0.2 -1.7 0.6 -0.7
Trunk predicted mass 1.0 5.5 11.2 -0.8 -3.1 -1.7 -2.2 -3.4 0.7 -1.7 -2.6 -3.1 -2.4 -2.5 -1.9 -3.0 1.6 -2.4
Standing height 0.5 4.5 8.7 -0.6 -2.0 -2.9 -1.5 -2.5 2.2 -2.4 -1.8 -3.0 -2.0 -2.3 -1.3 -2.0 1.7 -2.5
Length of working week for main job 2.2 2.5 6.8 -1.6 -0.8 0.4 -2.1 -1.5 0.8 -1.4 -2.6 -1.4 -1.9 -1.6 -1.9 -0.8 1.8 -1.4
Exposure to tobacco smoke at home 0.4 0.4 1.7 0.2 -0.8 -0.5 -0.2 -0.3 -1.2 0.6 0.4 -0.7 0.8 -0.3 0.3 -0.1 -1.3 0.1
Breastfed as a baby 0.5 0.7 2.3 -0.6 -1.5 -0.8 0.8 -0.7 0.2 -0.1 0.9 -1.1 0.3 -0.8 0.7 -0.8 -0.8 -1.0
Tense / ‘highly strung’ 0.7 1.2 3.9 0.6 0.7 0.3 1.2 1.4 1.4 1.6 -0.1 0.6 1.9 0.7 0.7 2.0 -0.1 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.3 7.7 -1.0 -0.9 -2.8 -0.7 -1.0 1.2 -0.4 -0.6 -1.0 0.1 -1.0 -1.6 -1.0 0.8 -0.8
Hair/balding pattern: Pattern 4 0.3 0.8 2.7 0.4 -0.1 -1.2 -0.5 -0.3 0.3 -0.8 -0.4 -1.6 1.4 -1.6 -0.7 0.1 -0.2 -1.0
Birth weight of first child 0.8 1.5 3.5 0.6 -1.9 -0.3 0.1 -1.5 1.7 -1.1 -1.0 -1.1 -0.8 -1.1 -0.4 -1.5 1.9 -1.7
Peak expiratory flow (PEF) 1.0 2.2 4.0 -0.4 -1.0 -1.9 -1.8 -2.0 -0.7 -1.2 -1.7 -1.2 -1.9 -1.6 -2.0 -1.7 0.5 -1.1
Pulse wave reflection index 0.4 0.5 1.4 0.4 -0.8 0.9 1.0 -0.2 1.2 -0.5 0.4 -0.1 -1.1 0.2 0.7 -0.0 0.7 -0.7
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.2 -0.8 -0.7 -0.3 -0.4 -0.4 -1.1 -0.0 -0.9 -0.1 0.3 -0.7 -1.1 -0.9 0.8 -0.4
Loud music exposure frequency 2.2 2.4 4.8 -0.8 -2.2 0.3 -0.8 -1.9 1.5 -1.7 -0.6 -2.2 -1.3 -1.7 -1.1 -1.6 1.6 -2.2
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 5.1 0.6 -0.3 0.8 2.2 0.9 0.1 0.9 1.7 1.3 0.3 1.6 2.3 0.4 -0.6 0.3
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.6 0.5 0.4 -0.3 -0.6 -0.1 -0.3 0.3 -0.1 -0.3 0.8 0.2 -0.4 0.3 -0.2 0.4
Blood clot in the leg (DVT) 0.9 1.2 4.1 0.6 -0.1 -0.5 -1.8 -0.6 0.5 -0.0 -1.6 -2.0 0.6 -1.4 -1.7 0.8 0.9 -0.2
Medication: Paracetamol 2.7 4.4 8.1 1.6 2.3 0.3 1.5 2.6 -0.5 2.7 1.8 2.2 2.2 2.4 1.7 2.2 -2.5 2.8
Headache pain in last month 0.7 1.1 6.2 -1.1 -0.7 -0.6 0.4 -0.6 2.5 -1.1 -0.1 -1.4 0.3 -1.3 -0.4 -0.9 0.5 -1.3
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 5.0 1.0 -0.3 -2.2 -0.6 -0.1 -1.5 0.3 0.2 -0.3 0.0 0.1 0.3 -0.0 -0.8 0.5
Glaucoma (self-reported) 0.5 0.6 4.2 -1.0 -0.4 2.0 0.3 -0.3 1.1 -0.3 -0.3 -0.7 0.3 -0.2 0.1 0.4 0.6 -0.7
Gout (self-reported) 1.5 2.1 3.6 1.4 1.3 0.0 1.8 1.9 0.0 1.7 1.5 1.8 1.3 1.7 1.6 1.4 -0.8 1.7
Hypothyroidism/myxoedema (self-reported) 6.4 12.6 23.6 -2.6 -4.2 -1.8 -2.0 -4.4 1.8 -4.5 -3.1 -4.0 -3.2 -4.4 -2.6 -4.0 3.7 -4.9
Medication: Amlodipine 0.2 0.3 2.0 -0.1 0.0 1.4 0.5 0.3 0.2 -0.3 -0.5 -0.0 -0.1 -0.3 0.1 0.4 0.4 -0.9
Medication: Ventolin 100micrograms inhaler 0.8 1.0 3.8 0.1 0.8 0.2 0.9 1.5 0.6 1.5 -0.1 1.0 1.1 1.2 0.3 1.9 0.2 0.9
Birth weight 0.2 0.3 2.7 -0.6 0.1 -1.6 -0.5 0.0 -0.5 -0.0 -0.4 0.4 -0.9 0.4 0.4 -0.1 0.4 0.3
Chronic bronchitis/emphysema (mother) 0.6 0.7 2.3 0.8 0.0 -1.5 1.3 0.5 -0.2 0.4 0.7 1.1 -0.8 1.3 1.3 0.2 -0.4 0.2
High blood pressure (siblings) 0.3 0.4 2.6 0.8 -0.1 0.9 1.0 0.1 1.6 -0.2 0.3 0.3 -0.3 0.3 0.8 0.2 0.2 -0.5
Forced vital capacity (FVC), Best measure 0.4 1.4 3.9 -0.4 -1.1 -2.0 -1.0 -1.3 1.1 -1.0 -1.1 -1.0 -1.5 -1.0 -1.3 -1.1 1.4 -0.8
Body fat percentage 0.2 0.8 3.3 -0.7 -1.8 0.7 1.4 -0.7 0.1 0.9 0.4 0.1 -1.1 0.2 1.1 -1.2 -0.4 -0.1
Leg fat percentage (right) 0.2 0.7 2.9 -1.0 -1.7 0.4 1.2 -0.7 -0.5 0.9 0.5 0.1 -0.7 0.1 0.9 -1.3 -0.7 0.0
Arm fat-free mass (right) 0.8 4.2 8.9 -0.9 -2.9 -0.7 -1.7 -3.0 1.0 -1.3 -2.4 -2.6 -2.4 -2.1 -1.7 -2.6 1.7 -2.0
Exposure to tobacco smoke outside home 0.2 0.2 0.7 -0.8 0.1 0.2 -0.1 0.4 -0.7 0.6 -0.2 0.1 -0.3 0.6 0.0 0.9 0.2 0.5
Comparative body size at age 10 0.3 0.8 2.4 -1.6 -0.8 -0.7 -0.4 -1.1 0.9 -0.6 -1.1 -1.0 -1.3 -0.7 -0.0 -0.8 0.4 -0.8
Number of full brothers 0.4 0.5 1.4 0.3 0.8 0.2 1.0 0.7 0.8 0.2 0.6 1.2 -0.4 1.0 0.9 0.3 -0.4 0.2
Worry too long after embarrassment 0.4 0.6 1.9 0.9 -1.4 -0.4 -0.2 -1.0 -0.2 -0.7 -0.2 -1.2 0.5 -1.1 -0.5 -0.6 -0.1 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 2.4 -1.5 -0.0 -1.5 -0.6 -0.5 1.4 -0.5 -0.4 -0.8 0.7 -0.7 -1.1 0.0 0.3 -0.4
Wheeze or whistling in the chest in last year 0.3 0.5 1.7 -1.3 -1.0 1.2 0.1 -0.8 -0.0 0.2 -0.6 -0.3 -1.1 -0.2 -0.1 -0.5 0.0 -0.5
Number of children fathered 3.0 3.4 7.0 -1.0 -2.5 -0.4 -1.6 -2.5 0.7 -1.4 -1.5 -2.5 -2.7 -1.8 -1.5 -2.3 1.3 -1.8
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.1 4.7 1.6 -0.6 0.0 -1.4 -1.0 1.6 -2.0 -1.8 -1.1 -1.4 -1.5 -1.5 -0.4 2.2 -1.8
Age at first live birth 0.1 0.1 0.4 -0.5 0.3 -0.6 -0.1 0.1 -0.6 0.0 0.2 -0.3 0.1 -0.2 -0.2 -0.0 -0.4 0.3
Pulse wave peak to peak time 0.7 0.8 4.2 -2.0 0.8 -1.2 -1.3 -0.2 -0.3 -0.2 -0.8 -0.5 0.9 -0.9 -1.1 -0.2 -0.2 -0.1
Health satisfaction 0.7 1.0 4.9 -0.6 -2.2 -0.3 0.5 -1.6 0.3 -0.2 0.3 -0.5 -0.7 -0.3 -0.1 -2.2 0.3 -0.8
Shortness of breath walking on level ground 0.8 0.9 3.1 -0.1 -1.7 0.4 1.3 -0.7 -1.0 0.5 1.8 -0.3 0.2 0.1 0.8 -1.3 -1.4 -0.2
Qualifications: College or University degree 0.1 0.4 1.0 0.3 -0.7 -0.4 -0.4 -0.8 -0.1 -0.6 -0.4 -0.5 -1.0 -0.6 -0.8 -0.9 1.0 -0.8
Eye problems/disorders: None of the above 1.1 1.3 3.7 0.0 -0.1 -1.7 1.3 0.8 -1.0 1.9 1.1 1.4 0.1 1.4 1.3 0.1 -0.9 1.4
Mouth/teeth dental problems: Loose teeth 0.6 0.8 3.6 -1.3 1.0 -0.1 -0.9 -0.1 -1.9 0.6 0.4 0.4 -0.4 0.5 -0.3 -0.2 -1.3 1.1
Emphysema/chronic bronchitis 1.4 1.6 3.1 -1.2 1.2 0.2 1.4 1.4 0.0 1.5 1.2 1.1 0.9 1.7 1.4 1.8 -0.9 1.4
Medication for pain relief, constipation, heartburn 1.0 1.6 4.4 -0.5 -0.3 -1.0 -1.9 -1.0 -0.9 -1.6 -1.3 -1.0 -1.0 -1.5 -2.1 -0.7 1.8 -1.2
Neck or shoulder pain in last month 1.7 2.4 6.1 0.6 2.5 0.4 0.4 1.8 -1.4 1.9 1.0 1.5 1.5 1.4 0.4 1.8 -1.9 2.4
Medication: Blood pressure 0.4 0.7 8.0 0.5 -0.2 2.8 0.3 -0.1 0.7 -0.4 -0.2 -0.3 0.1 -0.4 -0.3 -0.1 0.4 -0.8
Angina (self-reported) 1.1 1.4 4.9 -2.2 -0.3 0.5 -0.8 -0.9 1.5 -1.5 -0.6 -2.0 0.8 -1.6 -0.6 0.0 0.4 -1.4
Migraine (self-reported) 1.2 1.5 7.4 -0.9 -0.4 1.1 -0.1 -0.8 2.7 -1.0 -1.1 -1.1 -1.0 -1.2 -0.8 -0.4 2.2 -1.2
Medication: Ibuprofen 5.5 6.5 14.3 0.4 -3.3 -0.9 -2.7 -3.8 0.1 -2.2 -2.7 -3.0 -3.7 -2.4 -1.8 -3.5 1.9 -2.4
Medication: Allopurinol 0.2 0.2 1.2 0.3 0.1 -0.3 1.0 0.4 1.1 0.7 0.3 0.5 0.4 0.4 0.2 0.3 0.2 0.2
Medication: Omeprazole 0.5 0.7 2.7 -1.2 -0.7 0.4 1.6 0.3 0.0 0.2 1.4 0.3 -0.3 0.4 1.3 -0.1 -0.9 -0.2
Medication: Seretide 50 evohaler 0.4 0.5 3.2 -1.2 -0.8 1.8 0.4 -0.0 0.3 -0.0 -0.3 -0.3 -0.7 0.1 0.8 0.2 -0.0 -0.3
Mean time to correctly identify matches 0.4 0.8 1.9 1.4 -1.2 0.6 -1.1 -0.4 -1.0 0.9 -1.4 -0.9 -0.8 0.0 -0.6 0.1 0.8 0.5
Heart disease (mother) 0.5 0.6 2.3 -1.1 0.8 0.8 0.5 0.4 -0.6 0.4 0.5 1.5 -1.2 1.2 0.3 0.1 0.0 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 6.2 -0.6 1.7 -0.9 0.1 0.5 -1.4 0.3 1.5 0.9 1.1 0.4 0.3 -0.0 -2.5 1.0
Whole body fat mass 0.2 1.0 5.0 -0.7 -2.2 0.1 0.5 -1.5 0.5 0.4 -0.4 -0.8 -1.5 -0.5 0.3 -1.7 0.2 -0.6
Leg fat mass (right) 0.3 1.1 4.8 -1.2 -2.2 0.1 0.3 -1.5 0.3 0.2 -0.6 -0.9 -1.5 -0.7 0.1 -1.9 0.1 -0.8
Arm predicted mass (right) 0.8 4.2 9.3 -1.0 -2.7 -1.0 -1.7 -3.0 1.1 -1.4 -2.3 -2.6 -2.4 -2.1 -1.7 -2.7 1.5 -2.0
Pulse rate, automated reading 0.1 0.3 0.9 0.9 -0.3 -0.4 0.6 -0.4 0.1 -0.2 0.8 0.3 -0.5 0.5 0.6 -0.6 -0.9 -0.2
Alcohol intake frequency. 0.6 1.3 3.8 -0.2 1.7 0.3 -0.0 1.4 -0.4 1.7 0.3 1.0 1.1 1.1 0.4 1.3 -1.6 2.0
Comparative height size at age 10 0.6 3.1 6.5 0.5 -1.8 -2.4 -1.1 -2.4 1.1 -2.0 -0.7 -2.5 -2.2 -1.7 -0.7 -2.3 0.4 -1.9
Number of full sisters 0.5 0.6 1.5 -0.6 0.2 0.9 1.2 0.9 -0.0 0.9 0.8 1.2 0.7 1.0 0.9 0.4 -0.6 0.6
Suffer from ‘nerves’ 0.7 1.1 5.4 1.4 -0.5 1.2 -0.2 -0.1 2.3 -0.3 -1.2 -0.5 0.6 -0.3 -0.5 0.7 2.1 -0.7
Overall health rating 0.2 0.3 1.1 -0.7 -0.9 1.0 0.6 -0.2 -0.3 1.1 0.2 0.1 -0.2 0.5 0.3 -0.1 -0.3 0.5
Chest pain or discomfort 0.5 0.7 2.4 -1.6 -1.4 0.7 0.1 -0.5 1.4 -0.4 0.1 -1.3 0.1 -0.9 -0.3 -0.4 0.3 -0.9
Had major operations 0.4 0.5 2.6 -0.8 0.2 -0.2 -0.0 0.6 -0.7 1.0 0.5 0.1 1.6 0.4 0.3 0.7 -0.9 0.9
Age at last live birth 0.3 0.4 2.2 0.4 1.5 -0.3 -0.6 0.6 0.3 0.4 -0.1 0.2 0.4 0.5 -0.4 0.8 -0.1 1.0
Family relationship satisfaction 0.5 0.6 2.7 1.6 0.7 0.2 -0.6 0.7 -1.1 1.0 -0.1 0.3 0.8 0.5 -0.2 0.8 -0.7 1.1
Leg pain on walking 0.2 0.3 1.6 1.3 -0.1 0.1 0.7 0.3 -0.7 0.1 0.9 0.2 0.8 -0.0 0.3 -0.0 -0.3 0.0
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 2.8 -1.6 -1.1 -0.1 1.5 0.4 -1.0 1.6 1.0 0.4 1.7 0.5 1.5 0.3 -1.4 0.4
Commuting to job workplace: Car/motor vehicle 3.2 3.7 11.0 -1.0 1.2 0.9 0.7 2.0 -3.2 2.1 1.8 1.1 2.4 1.2 1.5 1.6 -3.3 2.2
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 2.0 0.6 -1.2 -0.5 0.5 -0.6 0.6 -0.4 -0.7 -0.2 -1.4 -0.2 -0.1 -0.5 1.4 -0.9
Medication: Aspirin 0.7 0.9 3.5 0.5 -0.8 1.9 0.8 -0.4 1.8 -0.9 -0.3 -0.5 -0.5 -0.4 0.5 -0.4 1.0 -1.3
Supplements: Vitamin C 0.6 0.7 3.1 0.9 0.4 0.6 0.8 1.1 -0.3 0.6 1.0 0.5 1.8 0.5 0.8 0.9 -0.5 0.5
Knee pain experienced in last month 0.7 1.1 5.7 -0.5 1.2 -0.3 -0.6 0.2 -2.1 0.7 0.6 0.1 0.8 0.4 0.3 0.0 -2.4 1.4
Hypertension (Self-reported) 0.3 0.9 7.9 1.2 -0.1 2.8 1.1 0.5 1.3 0.8 0.2 0.0 0.8 0.2 0.1 0.4 0.1 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 5.6 -0.8 -1.6 1.1 2.1 -0.1 2.4 -0.1 0.7 0.1 -0.5 0.2 1.6 -0.2 0.7 -0.9
Illnesses of father: Heart disease 2.6 3.6 15.3 -0.2 3.9 1.6 0.3 2.6 0.1 1.4 0.3 1.9 1.9 1.6 0.6 3.1 -1.4 2.3
Illnesses of siblings: Diabetes 0.3 0.4 2.5 -0.3 0.1 0.4 -0.0 -0.1 1.6 -0.8 -0.6 0.0 -0.2 -0.4 -0.5 -0.4 1.0 -0.6
Smoking status: Previous 0.7 1.0 2.8 0.4 0.4 -0.2 -1.4 -0.5 1.7 -0.6 -1.3 -1.3 0.4 -1.1 -1.7 0.0 1.2 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 3.5 0.3 -1.9 -1.3 0.0 -1.0 -1.2 -0.0 0.2 -0.8 0.2 -0.7 0.3 -1.2 -0.9 -0.9
Whole body fat-free mass 0.8 4.4 9.1 -0.7 -2.7 -1.2 -2.0 -3.0 1.0 -1.4 -2.6 -2.8 -2.2 -2.2 -1.7 -2.6 1.6 -2.0
Leg fat-free mass (right) 0.6 3.0 6.5 -0.6 -2.0 -0.6 -1.7 -2.4 1.3 -0.9 -2.5 -2.1 -2.0 -1.6 -1.4 -1.9 1.7 -1.6
Arm fat percentage (left) 0.2 0.7 2.1 -0.2 -1.2 0.8 1.4 -0.1 -0.1 1.4 0.4 0.7 -0.7 0.8 1.1 -0.6 -0.3 0.5
Average weekly red wine intake 0.4 0.5 2.7 1.3 0.0 1.6 0.8 0.5 0.2 0.5 0.3 0.6 0.3 0.8 0.6 0.7 0.5 0.1
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.6 1.6 0.2 -1.3 -0.5 0.5 0.6 0.7 -1.0 0.4 0.7 0.3 -0.5 0.5 0.4 0.7
Mood swings 0.5 0.9 3.5 -1.0 -1.9 0.8 0.2 -1.0 0.8 -0.6 -0.7 -0.7 -0.5 -0.8 -0.5 -1.4 1.0 -1.1
Loneliness, isolation 0.3 0.4 0.8 -0.4 -0.8 -0.9 0.4 -0.3 0.8 -0.5 -0.0 0.0 -0.6 -0.2 -0.5 -0.9 0.9 -0.8
Long-standing illness, disability or infirmity 0.4 0.7 3.0 -1.7 0.2 -0.0 1.3 0.1 0.6 0.4 1.3 0.2 0.2 0.3 0.7 -0.2 -1.6 0.3
Ever had bowel cancer screening 0.5 0.6 2.0 -1.4 0.1 0.9 -0.6 -0.4 1.4 -0.8 -0.4 -1.1 0.0 -0.9 -1.0 -0.0 0.6 -0.5
Diabetes diagnosed by doctor 0.3 0.5 3.0 -0.8 -0.2 1.7 0.8 0.5 1.0 0.1 0.5 0.4 0.3 0.7 0.8 0.4 0.5 0.3
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 3.9 0.1 -0.3 -2.0 -1.5 -1.2 0.6 -1.2 -1.3 -1.6 0.2 -1.7 -1.7 -0.7 0.9 -1.1
Friendships satisfaction 0.5 0.6 1.9 -1.0 -0.0 0.9 -0.8 -0.2 0.1 -0.7 -0.4 -1.1 1.4 -1.2 -0.7 0.2 -0.2 -0.6
Qualifications: nursing, teaching 0.3 0.5 1.8 0.1 0.3 0.1 0.8 0.6 0.1 1.3 0.7 0.0 1.0 0.6 0.8 0.9 -1.0 0.8
Commuting to job workplace: Walk 0.4 0.5 2.8 0.1 0.4 -0.0 -0.3 0.2 1.2 -0.9 -0.5 -0.1 0.1 -0.2 -0.5 0.5 1.7 -0.9
Eye problems/disorders: Cataract 1.0 1.1 2.9 0.1 1.4 1.4 -1.7 0.0 1.4 -0.7 -1.2 -1.1 0.5 -0.9 -1.5 1.2 0.7 0.1
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 4.1 0.1 0.6 -2.0 0.4 0.9 -0.2 0.8 -0.4 0.7 1.2 0.2 -0.2 0.9 0.2 0.4
Medication for cholesterol 0.6 1.0 4.9 0.1 0.6 -2.2 -1.8 -0.3 -1.4 0.0 -1.2 -0.2 -0.8 -0.1 -1.1 0.2 0.4 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 2.8 -0.2 -1.6 1.1 -0.4 -1.7 1.3 -1.3 -0.7 -1.1 -0.8 -1.4 -1.2 -1.6 1.1 -1.5
Back pain experienced in last month 0.4 0.6 2.3 0.1 -1.1 1.5 0.9 0.1 -0.7 1.3 0.9 0.4 0.7 0.8 0.7 -0.2 -0.5 0.4
Mineral and other dietary supplements 0.5 0.7 3.2 -0.8 -0.2 -1.3 1.1 0.1 -0.8 0.5 1.8 0.3 -0.0 0.3 1.1 -0.5 -1.2 0.6
Breast cancer (self-reported) 0.9 1.1 9.5 -0.8 0.7 -3.1 -0.9 -0.5 1.0 -1.2 -0.6 -0.4 -0.4 -0.4 -0.8 -0.4 0.6 -0.6
Asthma (self-reported) 1.0 2.0 3.3 -0.3 1.4 1.1 1.5 1.8 1.2 1.5 1.1 1.8 0.7 1.8 1.7 1.4 -1.4 1.6
Osteoporosis (self-reported) 0.3 0.3 1.4 0.1 -0.2 -0.8 -0.5 -0.2 0.8 -0.1 -0.7 -0.5 0.0 -0.7 -1.2 0.1 0.8 -0.4
Osteoarthritis (self-reported) 1.4 1.8 9.8 -0.2 1.1 -1.4 0.8 0.6 -2.0 0.8 1.7 0.9 1.4 0.6 1.0 -0.2 -3.1 1.3
Medication: Aspirin 0.6 0.8 4.6 0.1 -0.5 2.1 1.3 -0.0 1.5 -0.5 0.2 0.2 -0.2 0.1 1.0 -0.1 0.5 -0.9
Medication: Gliclazide 0.3 0.4 2.3 0.1 0.1 1.5 0.1 0.3 -0.7 0.4 0.8 -0.2 0.7 -0.1 -0.0 -0.0 -1.0 0.4
Illnesses of father: None of the above (group 1) 0.7 0.8 2.8 1.5 -1.3 -1.7 0.7 -0.2 -1.4 0.7 0.7 0.4 -0.5 0.3 0.7 -1.1 -0.5 0.3
Smoking status: Current 1.0 1.6 4.3 -1.1 2.0 -0.5 0.7 2.1 0.2 1.0 0.8 1.6 1.4 1.1 0.5 2.0 -0.4 1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 2.8 -0.2 -1.4 0.0 1.7 -0.2 0.2 0.1 1.0 0.6 0.0 0.3 0.5 -0.7 0.2 -0.5
Whole body water mass 0.8 4.4 9.0 -0.8 -2.8 -1.1 -2.0 -3.0 1.1 -1.3 -2.6 -2.8 -2.3 -2.2 -1.7 -2.6 1.7 -2.0
Leg predicted mass (right) 0.6 3.0 6.6 -0.7 -2.0 -0.5 -1.7 -2.4 1.4 -0.9 -2.6 -2.2 -2.0 -1.7 -1.5 -1.9 1.7 -1.6
Arm fat mass (left) 0.2 0.9 4.8 -0.4 -2.2 0.2 0.4 -1.4 0.2 0.5 -0.5 -0.5 -1.4 -0.4 0.2 -1.7 0.4 -0.6
Number of self-reported non-cancer illnesses 1.9 3.2 10.0 0.2 0.4 2.0 3.2 1.7 1.3 2.2 2.4 2.0 1.3 2.1 2.1 1.0 -0.6 1.7
Average weekly champagne plus white wine intake 0.6 0.8 2.9 -1.7 -1.3 -0.8 0.3 -1.0 0.4 -0.8 0.2 -0.9 -0.1 -0.9 -0.0 -1.3 0.1 -1.1
Miserableness 0.4 0.8 3.1 -0.6 -1.8 0.3 -0.1 -1.0 -0.1 -0.4 -0.8 -0.9 -0.0 -1.1 -0.7 -1.1 1.0 -1.2
Guilty feelings 0.4 0.6 1.7 -1.3 -0.7 -0.2 -1.1 -1.0 -0.3 -0.2 -1.1 -1.3 -0.4 -1.0 -0.7 -0.4 -0.2 -0.4
Wears glasses or contact lenses 0.8 0.9 1.9 0.7 -1.2 0.0 -0.4 -1.0 1.3 -0.9 -1.0 -1.4 -0.4 -1.3 -0.6 -0.8 1.1 -1.0
Ever taken oral contraceptive pill 1.4 1.5 7.5 -0.1 -1.4 -2.7 -0.9 -1.5 -0.1 -0.7 -1.4 -0.7 -1.8 -0.6 -0.6 -1.6 0.6 -0.8
Hearing aid user 0.6 0.7 3.2 -0.8 -0.5 -1.4 0.9 0.4 -0.5 0.3 1.8 0.1 1.2 -0.0 0.3 0.1 -1.1 0.1
Mother’s age at death 0.7 0.9 4.2 0.7 1.3 -2.1 -0.7 0.6 -0.8 0.5 0.4 -0.2 1.3 -0.1 -0.2 0.6 -1.5 1.1
Financial situation satisfaction 2.1 2.6 4.9 -1.6 -1.1 0.1 -2.1 -2.1 -0.1 -1.5 -1.6 -2.0 -1.3 -2.0 -2.2 -2.0 1.1 -1.4
Tinnitus: Yes, now most or all of the time 0.2 0.2 1.0 -1.0 -0.7 -0.8 0.7 0.2 -0.2 -0.3 0.2 -0.1 0.0 -0.4 0.3 -0.3 -0.1 -0.6
Commuting to job workplace: Public transport 0.3 0.3 1.1 0.5 -0.7 -0.8 0.4 -0.6 -0.5 -0.2 0.5 0.2 -1.0 0.2 0.7 -0.8 -0.2 -0.3
Eye problems/disorders: Glaucoma 0.5 0.6 2.9 -0.7 -0.0 1.7 1.2 0.3 1.3 0.0 0.7 -0.1 1.1 0.3 0.5 0.7 0.0 -0.5
Medication: Blood pressure 0.5 1.0 3.0 1.4 0.1 1.4 1.7 0.7 1.4 0.6 1.1 0.1 1.1 0.3 1.0 0.6 -0.9 0.1
Pain type(s) experienced in last month: Hip pain 1.5 1.9 5.2 0.6 1.7 -0.3 0.3 1.2 -1.5 1.8 1.3 1.1 1.1 1.7 0.9 1.2 -1.6 2.3
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.7 0.8 1.2 1.6 -0.5 1.1 0.4 0.6 -1.2 0.9 0.9 0.8 -0.2 1.3 0.7 0.7
High cholesterol (Self-reported) 0.6 1.0 7.1 -2.7 0.5 2.2 0.7 -0.0 1.0 -0.2 0.6 0.1 0.8 -0.2 0.3 0.5 -0.4 -0.3
Medication: Bendroflumethiazide 0.7 1.0 2.3 0.2 -1.2 1.1 -0.4 -1.2 0.8 -1.0 -0.6 -1.4 -0.6 -1.4 -0.8 -1.3 0.1 -1.5
Medication: Paracetamol 1.9 2.9 5.0 1.1 1.8 -0.2 1.3 2.0 -0.1 2.1 1.6 1.7 2.2 1.8 1.3 1.9 -2.2 2.2
Medication: Lisinopril 1.0 1.4 4.9 0.4 -0.2 0.5 1.8 0.8 0.9 0.8 2.2 -0.2 1.4 0.6 1.7 0.7 -1.8 0.5
Medication: Atorvastatin 0.5 0.6 4.6 -2.1 -0.7 0.5 0.6 -0.8 0.4 -0.6 0.8 -0.2 -0.3 -0.6 -0.2 -0.9 -0.2 -0.7
Illnesses of father: High blood pressure 0.6 0.7 1.4 0.8 0.4 1.2 1.1 0.8 0.4 0.8 0.9 0.5 0.2 0.9 1.0 0.9 -1.0 0.7
Alcohol drinker status: Never 0.2 0.2 1.3 0.8 -0.1 -0.0 -0.2 -0.1 -1.2 -0.2 -0.0 0.3 -0.8 0.3 0.4 -0.3 -0.3 0.0
Ever smoked 0.6 1.1 6.2 0.8 0.5 0.0 -0.5 0.4 2.5 0.3 -1.6 -0.2 0.0 -0.2 -1.0 0.9 2.0 0.0
Basal metabolic rate 0.7 3.8 8.2 -0.7 -2.8 -1.1 -1.6 -2.9 1.0 -1.2 -2.3 -2.5 -2.2 -2.0 -1.4 -2.6 1.5 -1.9
Leg fat percentage (left) 0.3 0.9 4.0 -1.2 -2.0 0.7 1.2 -1.0 -0.3 0.7 0.4 -0.2 -1.0 -0.1 0.8 -1.6 -0.7 -0.2
Arm fat-free mass (left) 1.0 5.1 11.3 -0.9 -3.3 -0.7 -1.7 -3.4 1.2 -1.6 -2.4 -2.9 -2.5 -2.4 -1.7 -3.0 1.7 -2.4
Number of operations (self-reported) 0.8 1.1 6.5 -2.3 0.2 -0.2 -0.1 0.2 2.6 0.2 -1.0 -0.5 0.3 -0.3 -0.6 0.5 1.6 0.1
Average weekly beer plus cider intake 1.9 2.8 5.7 -0.5 0.6 1.4 2.0 2.4 -0.1 2.2 1.6 1.7 2.2 1.8 1.9 2.2 -1.0 1.5
Irritability 0.2 0.4 2.1 0.5 -1.4 1.1 0.5 -0.1 -0.5 1.1 -0.5 0.1 0.6 0.2 0.1 0.1 0.3 0.1
Risk taking 0.7 1.0 2.8 -1.4 0.7 1.7 0.8 1.0 -0.5 1.1 0.7 0.8 1.5 0.8 0.7 1.0 -1.1 0.9
Ever had prostate specific antigen (PSA) test 0.9 1.0 3.2 -0.4 -1.5 -0.1 -0.9 -1.4 -0.0 -0.8 -0.3 -1.1 -1.5 -1.0 -0.8 -1.8 0.4 -0.7
Fractured/broken bones in last 5 years 0.4 0.5 1.8 0.5 0.0 -1.3 -1.2 -0.2 -0.1 0.6 -0.2 -0.3 1.3 -0.0 -1.2 0.2 0.1 0.8
Age started oral contraceptive pill 2.9 3.6 6.8 2.5 1.8 -1.1 2.1 2.1 -0.3 1.4 2.6 2.0 1.3 2.3 2.3 1.4 -1.9 1.9
Diastolic blood pressure, automated reading 0.4 1.1 4.0 2.0 0.1 1.3 1.3 0.6 1.9 0.9 0.6 0.9 -0.7 1.3 0.6 0.4 0.7 0.6
Ever depressed for a whole week 1.8 2.2 5.1 -0.4 -1.4 -0.8 -0.9 -1.4 1.4 -1.9 -1.3 -2.0 -0.4 -2.1 -1.6 -0.8 1.7 -2.2
Unable to work because of sickness or disability 0.4 0.5 2.7 -1.6 0.2 -1.2 -0.3 0.3 0.6 0.3 -0.3 -0.7 1.0 -0.4 -0.7 1.0 0.3 0.1
Commuting to job workplace: Cycle 0.4 0.4 1.7 1.3 -0.1 0.8 -0.8 -0.4 -0.8 -0.9 -0.2 -0.4 -0.8 -0.5 -0.3 -0.3 -0.1 -0.6
Myopia 1.8 2.6 8.4 0.1 -1.5 -1.2 -0.9 -1.2 2.9 -1.1 -2.3 -1.6 -1.7 -1.1 -1.1 -0.6 2.9 -1.5
Vascular/heart problems diagnosed by doctor 0.4 1.2 8.9 -0.6 -0.8 -3.0 -1.1 -1.0 -0.5 -0.9 -0.8 -0.3 -1.3 -0.4 -0.4 -0.9 0.9 -0.6
Cholesterol lowering medication 0.7 1.0 5.2 -1.6 -0.2 2.3 0.6 -0.6 0.3 -0.8 1.0 -0.8 0.9 -0.8 0.4 -0.3 -1.0 -0.8
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 4.1 -2.0 -0.8 0.7 1.9 0.3 0.3 0.2 1.7 0.3 -0.8 0.6 1.9 -0.2 -1.2 -0.1
Pain experienced in last month 0.3 0.6 2.6 0.3 -0.8 0.5 -0.2 -0.2 0.1 -0.8 -0.8 -0.0 -1.6 -0.1 0.3 0.1 1.5 -0.9
Supplements: Calcium 0.8 0.9 5.6 2.4 1.0 -1.5 -0.0 0.8 0.3 0.6 -0.5 0.8 -0.4 0.6 0.0 1.1 0.1 0.7
Basal cell carcinoma (self-reported) 0.7 0.8 3.1 1.7 -1.3 0.7 0.0 -0.3 1.0 -0.5 -0.9 -0.2 -1.1 0.0 0.1 -0.3 1.6 -0.9
Heart attack/myocardial infarction (self-reported) 0.8 1.1 3.4 -0.6 1.1 0.8 -1.8 -0.7 -0.4 -1.5 -1.1 -1.1 -0.6 -1.2 -1.7 0.0 0.0 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 3.8 0.7 -0.3 -0.6 -1.7 -0.6 0.1 0.1 -1.4 -1.9 0.9 -1.3 -1.6 0.6 0.7 -0.1
Heart disease (siblings) 1.0 1.2 6.0 -0.9 1.5 2.5 0.2 1.2 1.2 0.7 -1.0 0.7 -0.5 0.8 0.2 1.6 0.8 0.7
Alcohol drinker status: Previous 2.1 2.4 4.5 -0.2 1.7 -0.2 1.4 2.1 -0.6 1.9 1.4 1.8 1.9 1.6 1.0 1.8 -1.6 2.0
Pack years of smoking 0.4 0.6 2.2 -0.7 0.0 -0.5 -1.5 -0.6 -0.0 -0.6 -1.2 -1.2 -0.5 -0.7 -1.1 0.2 0.8 -0.2
Impedance of whole body 0.3 1.7 4.8 0.8 1.5 -0.5 1.6 1.7 -0.4 0.3 2.2 1.4 1.2 1.1 1.5 1.4 -1.4 1.0
Leg fat mass (left) 0.3 1.2 5.0 -1.2 -2.2 0.3 0.3 -1.6 0.3 0.2 -0.6 -0.9 -1.5 -0.7 0.2 -1.9 0.0 -0.7
Arm predicted mass (left) 1.0 5.2 11.2 -0.7 -3.1 -1.0 -1.9 -3.3 1.1 -1.6 -2.6 -2.9 -2.5 -2.4 -1.9 -3.0 1.8 -2.3