Hub : Genes

DRD4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Putamen basal ganglia 0.3060 0.1110 3.8e-03 0.070 NA 0.021 NA 0.066 9.7e-03 NA 1.1e-01 NA 1.2e-02
2 GTEx Esophagus Mucosa 0.0920 0.0360 2.1e-03 0.022 NA 0.050 NA 0.054 1.2e-02 NA 2.8e-04 NA 1.7e-04
3 METSIM Adipose 0.0893 0.0259 8.3e-06 0.078 0.051 0.050 0.06 0.068 1.0e-11 4.2e-08 5.1e-08 2.3e-09 2.0e-10
4 YFS Blood 0.1142 0.0276 5.9e-13 0.021 0.048 0.051 NA 0.031 1.2e-07 2.5e-15 2.7e-16 NA 2.0e-10
5 TCGA Breast Invasive Carcinoma 0.0276 0.0160 2.3e-03 0.008 0.013 0.008 NA 0.010 6.8e-03 9.0e-04 6.7e-03 NA 3.3e-03
6 TCGA Kidney Renal Clear Cell Carcinoma 0.0724 0.0364 5.0e-04 0.016 0.029 0.026 NA 0.025 6.2e-03 3.0e-04 5.3e-04 NA 7.7e-04
7 TCGA Brain Lower Grade Glioma 0.0478 0.0279 9.3e-03 0.036 0.009 0.020 NA 0.025 5.9e-05 2.6e-02 2.2e-03 NA 7.2e-04
8 TCGA Pancreatic Adenocarcinoma 0.1800 0.0800 4.1e-03 0.022 0.036 0.068 NA 0.045 4.1e-02 1.2e-02 8.6e-04 NA 5.7e-03
9 TCGA Thyroid Carcinoma 0.0930 0.0480 6.9e-04 -0.003 0.033 0.015 NA 0.000 8.4e-01 3.4e-04 1.1e-02 NA 2.9e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 1.1 1.7 3.9 1.6 0.0 1.2 0.7 2.0 1.0 1.4 -0.1 2.0
Bipolar Disorder or Schizophrenia 0.4 1.0 2.1 0.2 0.8 -0.9 1.4 -1.1 -0.7 -1.3 -1.2 -0.5
Depressed Affect (Nagel 2018) 0.3 0.6 1.3 -0.4 0.9 0.9 1.1 -1.0 0.6 -0.2 -0.7 0.8
Depression (Nagel 2018) 0.3 0.5 1.5 1.2 1.1 0.1 0.6 -1.0 0.3 -0.1 -0.2 0.3
Intelligence (Savage-Jansen 2018) 0.4 1.3 3.9 1.3 2.0 -0.7 0.8 -1.5 0.5 -1.2 -0.8 0.6
Neuroticism (Nagel 2018) 0.2 0.4 1.4 0.3 -0.1 1.1 0.3 -0.5 0.3 -0.2 -1.2 0.7
Schizophrenia (2018) 1.8 3.7 9.0 -0.9 0.9 -1.9 1.1 -3.0 -1.7 -2.7 -1.5 -2.3
Schizophrenia vs Biploar Disorder 1.3 1.7 4.9 -0.3 0.0 0.0 -1.0 -1.1 -2.0 -2.2 -0.8 -2.0
Worry (Nagel 2018) 0.4 0.8 1.9 -1.1 -1.0 -0.3 -1.3 -0.3 -0.9 -0.6 -1.4 -0.6
Alzheimer’s Disease (in mother) 0.4 0.5 2.5 0.1 -0.0 -0.9 -0.5 -0.8 -0.4 -1.6 -0.4 -0.0
Alzheimer’s Disease (in father) 0.3 0.3 0.9 -0.8 -0.8 0.2 0.2 0.5 -0.6 -0.4 -0.9 0.2
Alzheimer’s Disease (including proxy) 0.4 0.5 2.5 -0.7 -0.7 -0.5 -0.5 -0.4 -0.5 -1.6 -0.6 0.1
Crohns Disease (2017) 0.5 1.1 3.9 -0.5 0.9 -1.5 0.9 -1.0 0.8 -0.0 2.0 -0.3
Irritable Bowel Disease (IBD) 0.8 1.8 6.2 -2.0 0.3 -2.1 0.8 -0.4 0.7 0.4 2.5 -0.5
Ulcerative Colitis (UC) 1.0 1.8 9.4 -3.1 -0.4 -1.9 0.3 0.2 -0.2 0.6 1.3 -0.8
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.4 0.7 2.1 -0.3 -0.6 1.1 -0.7 1.1 0.6 0.8 -0.3 1.5
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.7 1.3 0.9 -0.7 1.2 -0.1 0.4 -1.1 -0.4 1.1
Breast Cancer 1.8 4.4 21.7 4.7 0.2 -0.2 2.6 -1.9 0.1 -0.5 -2.6 0.4
Ovarian Cancer 0.7 1.0 2.6 -1.3 0.6 -1.3 0.3 -1.6 -0.6 -0.5 -0.5 -1.2
Prostate Cancer 0.6 0.8 2.7 0.2 -1.6 0.3 -0.6 1.3 0.2 0.1 1.3 0.6
Age at First Birth 1.5 2.2 8.9 -3.0 -0.6 -0.4 0.1 -0.3 -1.8 -1.3 0.7 -2.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.2 1.6 5.3 -0.2 1.4 -1.1 1.3 -0.1 1.9 -0.0 0.8 2.3
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.6 1.0 5.5 0.4 0.4 -0.0 1.2 -0.4 0.7 0.6 2.3 -0.7
Mean Putamen Volume 1.1 1.3 3.2 -1.0 -0.9 -0.8 -0.9 -0.5 -1.1 -1.8 0.8 -1.7
Fasting Glucose 1.1 1.3 3.8 -1.3 1.1 -2.0 1.2 -1.2 0.6 -0.7 0.8 0.3
HbA1C 4.9 5.5 9.8 2.6 1.3 2.7 2.8 0.6 3.1 2.0 1.3 3.1
HDL Cholesterol 1.3 2.2 6.3 -0.1 -2.5 2.1 -1.4 2.2 -0.8 1.1 -0.7 0.0
LDL Cholesterol 0.5 0.9 3.2 0.8 0.4 -0.3 -0.1 -0.8 -1.3 -1.8 -0.3 -1.1
Lupus 7.1 10.7 37.8 -0.8 6.1 -1.2 3.4 -5.6 2.6 -1.0 -1.6 1.9
Neuroticism (2016) 1.8 2.6 7.5 -2.7 -1.2 0.6 -1.4 0.2 -2.5 -0.4 -1.3 -2.1
Primary Biliary Cirrhosis 1.7 2.5 7.0 -0.3 2.6 -0.0 1.7 -1.8 2.2 0.1 -0.7 1.9
Rheumatoid Arthritis 0.6 0.8 2.8 -0.0 1.1 -0.1 1.0 -1.7 1.1 1.2 -0.4 0.1
Schizophrenia (2014) 0.7 1.6 5.2 0.1 0.7 -1.4 0.6 -0.8 -1.8 -2.3 -0.4 -1.6
Triglycerides 1.1 1.8 5.0 1.2 2.2 -1.1 1.6 -1.8 1.5 0.5 0.9 0.0
Type 2 Diabetes (T2D) (2012) 1.1 1.2 6.4 0.0 0.0 0.0 0.0 -0.8 1.8 0.8 2.5 0.4
Ulcerative Colitis 1.4 2.1 4.3 -1.9 -1.2 -1.5 0.4 1.8 -1.2 -1.5 2.1 -0.7
Blood Eosinophil Count 0.3 2.1 5.6 1.6 2.3 -0.5 1.6 -2.4 0.2 -1.4 -0.7 -0.2
Blood Platelet Count 0.8 9.4 49.3 0.1 -1.9 -0.8 -7.0 2.1 2.2 1.8 4.0 1.7
Blood Red Count 0.1 1.4 4.0 -1.7 0.3 -0.4 0.7 1.6 0.9 2.0 1.1 0.8
Blood White Count 0.1 0.8 2.8 -0.6 1.0 0.6 1.1 -0.1 0.8 -0.2 -1.0 1.7
Heel T-Score 0.1 0.5 1.3 0.5 1.1 -0.0 1.1 0.5 0.7 0.8 0.8 0.5
BMI 0.4 2.3 11.1 -3.3 0.4 -0.7 1.6 -0.1 1.3 0.6 1.8 1.0
Height 0.3 5.6 16.7 1.6 3.8 -0.3 4.1 -2.9 1.5 -1.1 -1.7 1.5
Waist Hip Ratio (WHR) 1.3 5.9 32.7 5.7 1.6 -2.6 1.5 -2.2 -0.1 -1.9 -0.8 -0.3
Systolic Blood Pressure 0.4 1.9 6.0 -1.9 -1.4 -0.1 -2.5 -0.4 -1.5 -0.3 -1.1 -1.4
Smoking Status 0.6 1.4 5.6 1.0 -2.4 1.8 -1.3 0.4 0.0 0.5 -0.7 -0.4
Allergy or Eczema 1.4 3.8 7.5 -2.0 -0.3 0.4 0.1 -2.0 -2.7 -2.7 -2.1 -2.6
Cardiovascular Disease 0.9 3.0 9.2 -1.9 0.2 -1.2 -0.1 -3.0 -1.6 -1.0 -2.3 -2.1
Hypothyroidism (self reported) 3.8 8.8 32.9 -0.4 5.7 -1.5 3.3 -3.3 3.8 0.5 1.4 2.2
Respiratory disease 0.7 1.6 5.6 -1.1 0.0 -0.6 -0.6 0.5 -2.3 -1.0 -0.5 -2.4
Type 2 Diabetes (T2D) (2018) 0.4 0.7 2.0 0.9 -1.4 -0.2 -1.2 -0.1 -0.9 -0.6 0.3 -1.0
Lung FEV1/FVC ratio 0.3 1.6 7.0 -2.6 -1.9 0.8 -0.4 1.3 -0.0 0.9 0.7 0.5
Lung FVC 0.3 1.8 5.9 -1.1 2.4 0.6 1.0 -1.9 1.3 1.0 -1.0 0.6
Neuroticism 0.4 0.9 2.6 -1.0 -0.2 0.2 -1.2 -0.2 -0.9 -1.4 -1.6 0.0
Chronotype (morning person) 0.5 1.0 4.1 -0.4 2.0 0.1 1.7 -0.2 1.1 0.5 0.2 1.0
Hair Pigment 0.0 1.2 3.6 -0.9 0.9 1.2 0.4 -1.9 1.6 1.3 0.3 0.3
Tanning 0.0 0.2 0.7 -0.5 -0.4 -0.6 0.1 -0.2 0.2 0.8 0.0 -0.6
Hand grip strength (left) 1.1 2.9 11.3 0.6 1.7 -0.8 3.4 -1.3 2.3 1.0 0.2 1.7
Number of treatments/medications taken 0.5 1.0 3.3 -0.6 1.6 -1.1 0.2 -1.8 0.1 -0.4 -0.9 0.1
Average weekly spirits intake 0.4 0.5 1.4 1.2 1.0 0.6 -0.3 -0.8 0.9 0.2 -0.2 0.2
Sensitivity / hurt feelings 0.3 0.5 1.2 0.3 -0.6 0.1 0.7 1.0 0.6 0.9 -0.4 1.1
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.3 -0.2 1.2 -0.1 -0.5 -0.9 0.2 0.7 -0.2 0.1
Hearing difficulty/problems: Yes 0.5 0.8 2.4 -0.9 -0.4 -1.2 0.7 -0.4 1.0 -0.6 1.6 0.7
Relative age of first facial hair 0.3 0.7 3.4 1.8 0.1 0.7 0.4 -0.5 0.8 0.6 -0.7 0.8
Other serious medical condition/disability diagnosed by doctor 1.3 1.6 4.0 -1.5 -0.6 -1.2 0.3 -0.3 -1.6 -1.6 1.3 -2.0
Ever used hormone-replacement therapy (HRT) 1.1 1.4 3.9 -1.4 0.6 -0.6 0.3 -2.0 -0.8 -1.6 -1.1 -1.0
Ever had hysterectomy (womb removed) 1.3 1.5 4.1 -1.7 0.2 -0.3 -1.4 -1.5 -1.0 0.2 -2.0 -1.0
Systolic blood pressure, automated reading 0.3 0.8 2.1 -1.4 0.2 1.2 -0.5 -0.9 0.7 1.3 -0.4 0.3
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.2 1.0 -1.1 0.3 0.5 0.3 -0.5 0.2 0.7 -0.8
Angina 1.1 1.5 5.0 1.8 1.1 -1.1 2.2 -1.3 1.0 0.4 -0.1 0.2
Medication for hormone replacement therapy 0.5 0.6 1.3 -0.9 -0.5 -0.6 -0.9 -0.5 -0.8 -1.1 -0.3 -0.8
Vitamin and mineral supplements 0.6 0.8 3.6 1.9 -0.8 0.6 -0.3 1.2 -0.5 -0.3 0.4 -0.4
Supplements: Zinc 1.0 1.1 3.1 -1.0 -1.1 0.7 -1.6 0.3 -0.7 -0.7 -1.8 0.4
Medication: Co-codamol 1.4 1.7 3.4 -0.9 -0.2 -0.7 -1.6 -1.2 -1.6 -1.9 -1.8 -0.8
Medication: Metformin 0.1 0.2 0.5 0.5 -0.2 0.4 0.7 -0.5 -0.3 0.1 -0.1 -0.6
Diabetes (father) 1.4 1.8 3.7 0.4 1.4 1.2 1.0 1.2 1.6 1.9 0.6 1.9
Diabetes (mother) 1.1 1.4 3.1 -0.6 1.5 -1.6 1.8 -0.7 -0.7 -1.7 0.2 -0.4
Severe depression (siblings) 0.4 0.4 1.5 -0.3 -1.2 0.5 -1.0 0.2 -0.3 -0.2 0.6 -0.6
Pack years adult smoking proportion 1.6 2.4 8.4 -1.0 -0.1 2.9 1.2 1.4 1.6 1.7 1.0 1.5
Impedance of leg (right) 0.6 2.9 14.9 3.9 1.3 -0.7 1.2 -1.1 -0.6 -1.1 0.9 -1.9
Leg fat-free mass (left) 0.3 1.6 4.1 -2.0 0.2 0.2 2.0 -0.1 1.5 0.8 0.1 1.9
Trunk fat percentage 0.3 1.3 3.5 -1.3 0.4 -1.2 1.9 -1.4 -0.8 -1.3 -0.5 -0.8
Hand grip strength (right) 1.4 3.8 14.6 0.4 2.7 -0.4 3.8 -1.5 2.4 1.1 -0.1 1.7
Townsend deprivation index at recruitment 0.8 1.1 4.2 0.0 -1.4 0.6 -2.1 0.9 -1.2 0.0 0.2 -1.0
Current tobacco smoking 0.9 1.4 6.9 0.3 -2.6 0.6 -1.3 0.8 -0.8 0.2 -0.1 -1.5
Average weekly fortified wine intake 1.2 1.4 3.7 -0.5 -0.4 -1.6 -0.9 -1.2 -1.3 -1.4 -0.0 -1.9
Maternal smoking around birth 1.5 2.2 7.2 -0.9 -1.2 -0.6 -1.3 -0.3 -2.7 -1.6 -1.9 -1.4
Fed-up feelings 0.6 1.1 5.0 0.0 0.7 1.2 -0.1 -1.4 0.1 0.1 -2.2 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.7 -0.2 0.3 0.4 0.8 -0.9 0.2 0.3 -0.3 -0.2
Relative age voice broke 1.0 1.6 5.1 0.1 -1.3 0.5 -0.1 0.1 -2.3 -1.5 -1.7 -1.5
Taking other prescription medications 2.0 3.1 7.7 -2.5 1.2 -1.6 0.8 -2.8 -1.2 -1.8 -1.0 -1.9
Age when periods started (menarche) 0.3 0.8 3.4 1.1 -0.5 0.1 -1.9 1.4 -0.2 0.7 0.3 0.3
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 3.1 -0.7 1.1 -1.5 -1.4 -1.6 -0.4 -0.5 -1.8 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 3.6 1.3 1.9 -1.3 0.0 -1.1 0.3 -0.2 -0.7 0.5
Tinnitus: Yes, but not now, but have in the past 2.0 2.2 6.9 -1.2 -0.1 -2.6 -0.5 -0.2 -1.9 -1.9 -0.1 -1.8
Qualifications: CSEs or equivalent 0.4 0.5 1.2 0.2 0.6 0.7 1.1 0.5 0.8 -0.2 1.0 0.9
Serious illness, injury or assault to yourself 1.1 1.4 4.3 -2.0 0.5 -2.1 0.7 0.3 -0.2 -0.5 1.6 -0.4
High blood pressure 0.6 1.6 4.0 -1.4 0.6 -1.3 -1.2 -2.0 -0.9 0.1 -1.8 -1.0
Hayfever, allergic rhinitis or eczema 1.0 2.3 4.9 -1.3 -0.6 1.0 -0.9 -1.1 -2.2 -1.8 -1.6 -2.2
Multivitamins +/- minerals 0.9 1.1 4.0 -2.0 0.9 -0.1 0.7 -1.1 0.8 0.7 -1.3 0.9
Stomach or abdominal pain in last month 1.8 2.2 4.8 -2.2 0.1 -1.6 -1.5 -1.7 -1.2 -0.9 -0.7 -2.1
Supplements: Glucosamine 1.0 1.3 3.1 -0.3 1.6 0.3 -0.7 -0.8 1.5 1.4 -0.4 1.8
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 4.9 0.7 1.1 -0.7 0.6 -2.2 -0.1 -0.4 -1.0 -0.8
Medication: Atenolol 1.4 1.7 4.7 1.3 0.8 0.2 2.2 -0.8 1.8 1.1 -0.4 1.7
Medication: Levothyroxine sodium 2.6 4.3 20.3 -0.1 4.5 -0.2 1.9 -2.0 2.3 -0.1 -0.2 2.4
Sitting height 1.1 7.9 22.8 0.0 4.8 0.0 4.2 -3.3 3.6 0.8 0.1 2.5
Chronic bronchitis/emphysema (father) 2.4 2.8 8.2 2.3 1.1 2.1 0.3 -0.0 2.1 1.1 -0.5 2.9
High blood pressure (mother) 0.5 0.7 2.8 -1.7 0.6 0.9 0.2 -0.8 0.0 -1.3 0.3 0.2
Body mass index (BMI) 0.3 1.5 10.0 -3.2 -0.4 -1.0 1.3 -0.4 0.1 -0.0 0.1 0.4
Impedance of leg (left) 0.6 3.1 11.9 3.5 1.6 -1.2 1.2 -1.5 -0.8 -1.5 0.6 -2.2
Leg predicted mass (left) 0.3 1.6 4.0 -2.0 0.2 0.1 2.0 -0.0 1.5 0.8 0.3 1.9
Trunk fat mass 0.3 1.4 5.6 -1.6 0.6 -1.1 2.4 -1.4 -0.1 -0.8 -0.4 -0.1
Waist circumference 0.3 1.1 3.1 -1.0 0.4 -1.8 1.5 -1.2 -0.4 -1.1 0.0 -0.3
Number of incorrect matches in round 0.2 0.4 1.1 0.8 0.9 0.0 0.1 -0.3 0.5 -0.6 -0.5 1.1
Past tobacco smoking 0.6 1.2 3.0 -1.6 0.5 -1.1 -0.2 0.6 -1.5 -1.7 0.4 -1.0
Alcohol usually taken with meals 1.6 2.5 7.1 1.7 1.2 -0.7 2.4 -0.2 1.8 1.2 2.7 0.2
Nervous feelings 0.2 0.4 2.5 0.0 0.3 0.5 -0.5 -0.3 0.0 0.2 -1.6 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.2 -0.4 -0.2 0.5 -0.7 0.8 0.1 1.1 -0.0 0.3
Hearing difficulty/problems with background noise 0.3 0.4 2.0 -1.4 -1.0 0.1 -0.7 -0.6 0.2 -0.0 -0.2 -0.3
Hair/balding pattern: Pattern 2 0.7 0.9 4.2 -0.1 -0.4 1.2 2.0 -0.8 1.1 0.2 0.8 -0.1
Had menopause 1.4 1.7 3.9 -1.7 -0.9 -1.2 -1.0 -1.3 -1.6 -0.8 -0.7 -2.0
Had other major operations 0.9 1.1 2.3 0.2 1.2 0.5 1.4 -1.3 0.6 -0.3 -1.5 1.2
Forced vital capacity (FVC) 0.7 2.5 5.3 -0.8 2.3 1.3 2.3 -1.7 2.1 1.4 0.3 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 3.8 0.8 1.9 -1.2 0.7 -1.2 0.1 -0.6 -0.6 0.5
Ever unenthusiastic/disinterested for a whole week 3.2 3.9 8.8 1.3 3.0 0.9 2.1 -1.9 2.7 2.2 -0.1 1.8
Qualifications: None of the above 0.2 0.4 1.2 0.6 0.4 -1.1 0.2 0.1 0.3 0.4 1.0 -0.4
Financial difficulties in last 2 years 0.1 0.2 0.8 0.1 -0.4 0.2 -0.9 0.5 0.1 0.1 0.2 0.4
Mouth/teeth dental problems 0.7 1.1 2.7 -0.9 0.2 1.2 -1.4 -1.0 -0.6 -1.2 -1.6 -0.1
Heart attack 1.1 1.4 4.6 2.1 0.8 0.5 1.2 0.6 1.3 1.4 0.7 1.1
Allergy 0.7 1.6 3.6 1.2 -0.0 -0.8 0.8 1.0 1.8 0.9 1.6 1.9
Pain all over the body in last month 0.2 0.2 0.8 0.2 0.4 -0.9 0.5 -0.6 -0.3 -0.5 -0.0 -0.3
Diabetes (self-reported) 0.3 0.5 1.9 0.5 -1.4 0.1 -0.9 0.0 -0.7 -0.4 0.2 -0.7
Hayfever/allergic rhinitis (self-reported) 2.3 3.1 6.7 -1.5 -1.6 0.2 -1.4 -0.9 -2.6 -2.3 -1.2 -2.6
Medication: Ramipril 1.6 2.0 11.6 -1.6 -0.0 0.8 -1.0 -1.1 -0.5 -0.1 -3.4 0.8
Medication: Simvastatin 0.4 0.6 1.8 1.0 0.2 -0.8 -0.4 -0.6 -0.6 -1.2 -1.3 0.2
Fluid intelligence score 0.4 0.9 2.2 0.7 1.4 -0.4 1.5 -0.9 0.8 -1.1 -0.3 0.9
Illnesses of siblings 0.6 0.8 5.4 0.3 0.1 0.4 1.0 0.2 0.8 0.1 2.3 -0.5
Neuroticism score 0.2 0.5 1.2 -0.9 0.7 -0.5 -0.2 -1.0 0.3 -0.2 -1.1 0.6
Weight 0.3 1.7 6.4 -2.4 0.6 -0.8 2.5 -1.1 0.8 -0.0 0.0 0.9
Impedance of arm (right) 0.3 1.2 4.3 2.1 0.4 0.2 -0.7 -0.3 -1.3 -1.0 -0.5 -1.6
Arm fat percentage (right) 0.2 0.8 4.4 -2.1 -0.4 -0.9 1.0 -0.6 -0.5 -0.6 -0.3 -0.1
Trunk fat-free mass 0.4 2.1 5.9 -1.2 0.8 -0.5 2.4 -0.5 2.2 0.8 1.2 2.0
Hip circumference 0.5 2.2 15.7 -4.0 -0.2 0.4 1.8 -0.6 -0.2 -0.5 -0.2 0.1
Time employed in main current job 2.0 2.4 13.5 -0.4 1.1 0.9 -1.2 -1.8 -0.1 0.1 -3.7 1.0
Alcohol intake versus 10 years previously 0.6 0.8 2.2 -0.5 -1.5 0.3 -1.4 0.3 -0.5 1.2 -0.2 -1.0
Father’s age at death 1.3 1.8 4.3 0.4 -1.6 -0.6 -0.1 1.3 -1.8 -2.1 1.2 -1.5
Worrier / anxious feelings 0.2 0.4 1.8 -0.5 -0.8 -0.4 -0.8 0.3 0.1 1.3 -0.5 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.6 -0.8 0.2 -0.2 -0.6 0.5 -0.4 -0.0 0.3 0.2
Falls in the last year 0.6 0.7 1.4 1.0 -1.1 -0.8 -0.1 0.9 -1.2 -1.0 0.7 -0.3
Hair/balding pattern: Pattern 3 0.8 1.1 3.2 0.2 -0.6 0.2 -1.8 1.8 -1.4 -0.5 -1.1 0.4
Number of live births 0.6 0.8 3.3 0.7 -1.1 -0.7 0.1 -1.1 -0.5 0.7 -0.3 -1.8
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 4.7 -2.2 1.6 1.1 1.5 -1.1 1.7 1.5 0.4 0.8
Pulse rate 0.2 0.3 1.5 -1.2 -0.2 -0.1 0.1 -0.4 -0.5 -0.5 -0.0 -0.4
Happiness 0.9 1.1 3.8 -1.3 0.3 0.3 2.0 -1.8 0.6 0.7 -0.2 -0.4
Noisy workplace 1.0 1.2 4.2 -1.7 0.3 1.4 -0.4 -0.0 0.8 2.0 -0.7 0.4
Qualifications: A levels/AS levels or equivalent 0.2 0.4 2.1 -0.1 -0.0 0.4 0.2 -0.8 -0.5 -0.1 -1.4 -0.5
Serious illness, injury or assault of a close relative in last 2 years 1.7 1.9 6.8 -2.6 -0.5 0.3 -2.0 0.2 -1.6 -0.6 -0.8 -1.6
Mouth/teeth dental problems: Dentures 0.6 1.1 3.8 -0.2 -0.1 -1.1 1.2 0.0 0.9 1.5 1.9 -0.6
Asthma 1.1 2.1 6.5 -1.6 0.1 -1.0 -0.5 -0.7 -2.2 -1.5 -1.1 -2.5
Medication: Ibuprofen (e.g. Nurofen) 2.5 3.1 13.1 1.1 1.8 0.2 0.9 1.0 2.4 1.3 1.0 3.6
Medication: Cholesterol lowering 0.5 0.8 3.1 1.4 -0.0 -0.4 0.7 -0.7 -0.9 -0.2 -1.8 -0.4
Depression (self-reported) 0.8 1.0 4.3 -0.6 0.4 0.8 0.7 -1.2 0.9 2.1 -0.0 -0.9
Medication: Lansoprazole 1.1 1.3 3.8 -1.1 1.1 -1.0 1.9 -1.9 0.4 -0.8 0.5 -0.1
Prospective memory result 0.6 0.7 3.4 -1.8 -0.8 0.3 -1.3 0.2 -0.7 0.1 0.3 -0.6
Lung cancer (father) 2.1 2.5 8.0 0.8 -2.8 -0.2 -2.3 1.0 -2.0 -0.5 -1.4 -1.2
Illnesses of mother 0.5 0.6 2.2 1.5 -0.7 -0.7 0.6 0.7 0.5 1.1 0.2 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.7 4.6 -2.1 1.3 1.6 1.4 -0.7 1.1 1.5 -0.1 0.4
Pulse wave Arterial Stiffness index 0.7 0.8 2.3 0.5 1.1 -0.4 -0.7 -0.6 -1.2 -1.5 -0.6 -0.7
Impedance of arm (left) 0.4 1.9 6.4 2.5 -0.2 0.2 -1.2 0.1 -1.9 -1.0 -0.6 -2.1
Arm fat mass (right) 0.3 1.2 6.2 -2.5 0.0 -0.8 1.7 -0.9 0.3 -0.0 -0.1 0.5
Trunk predicted mass 0.4 2.3 6.1 -1.2 0.8 -0.4 2.5 -0.4 2.3 0.9 1.3 2.1
Standing height 0.3 2.9 10.1 1.5 2.6 0.0 3.2 -1.8 1.7 0.0 0.0 1.0
Length of working week for main job 1.6 1.8 7.4 -0.1 1.2 0.6 -0.2 0.8 1.9 1.5 -0.8 2.7
Exposure to tobacco smoke at home 0.6 0.7 2.8 -0.3 -1.0 -1.2 0.4 0.7 0.2 -0.5 1.7 -0.1
Breastfed as a baby 2.4 3.0 16.4 0.8 0.6 -4.0 -0.4 -2.0 -0.8 -1.4 0.2 -1.5
Tense / ‘highly strung’ 0.9 1.6 5.1 -1.2 -0.9 -0.4 -2.2 -0.7 -1.0 -0.3 -2.2 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 3.1 -1.4 0.6 -0.7 1.2 -1.8 1.2 1.6 1.3 -0.9
Hair/balding pattern: Pattern 4 0.3 0.7 2.6 -0.1 0.9 -1.5 0.0 -1.6 0.7 0.3 -0.5 0.0
Birth weight of first child 0.6 1.1 3.0 -0.6 1.7 0.3 1.0 -1.7 0.5 -0.5 -1.2 0.6
Peak expiratory flow (PEF) 1.3 3.1 8.6 -0.8 2.4 0.8 2.9 0.1 2.1 1.9 1.1 1.7
Pulse wave reflection index 1.1 1.3 2.9 -0.6 1.6 -0.1 0.1 -1.7 -0.9 -1.4 -1.5 -0.8
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.8 -1.0 -0.0 0.9 1.1 -0.3 1.2 1.3 -0.0 1.0
Loud music exposure frequency 0.5 0.6 2.8 0.2 0.4 -0.6 0.3 -1.7 1.1 -0.0 0.2 0.5
Qualifications: O levels/GCSEs or equivalent 1.8 2.8 7.4 -2.6 -0.3 -0.9 -1.0 -0.3 -2.2 -2.7 -1.7 -1.2
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.5 1.2 0.0 -0.4 0.4 0.8 -0.3 0.7 0.8 -0.2
Blood clot in the leg (DVT) 0.8 1.0 3.5 0.8 -0.3 0.4 0.7 0.2 1.6 1.9 0.5 1.1
Medication: Paracetamol 1.4 2.3 4.8 -1.4 -2.2 -0.5 -1.9 1.0 -2.0 -0.4 -0.1 -2.2
Headache pain in last month 2.0 3.4 11.4 -2.2 2.1 -2.5 -0.0 -3.4 -0.3 -0.2 -0.7 -1.9
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 3.9 1.0 -0.9 0.8 -0.1 1.2 0.5 -0.2 2.0 0.1
Glaucoma (self-reported) 0.4 0.4 1.3 0.5 0.5 0.7 0.0 -0.9 0.0 -0.5 -1.1 0.6
Gout (self-reported) 1.0 1.3 3.0 -1.5 -1.3 0.1 -0.0 -0.5 -1.7 -0.9 -1.1 -1.7
Hypothyroidism/myxoedema (self-reported) 3.1 6.1 22.4 0.0 4.7 -0.2 3.1 -2.6 3.1 0.3 0.3 2.5
Medication: Amlodipine 0.6 0.8 2.6 -0.2 0.8 -1.5 -0.3 -0.8 -0.7 -0.7 -1.6 0.3
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.6 -0.2 -1.1 1.0 -0.1 -0.2 -0.6 0.2 -1.3 -0.3
Birth weight 0.3 0.7 3.5 0.2 -1.1 0.7 0.4 1.9 -0.0 -0.4 0.6 0.7
Chronic bronchitis/emphysema (mother) 0.9 1.1 4.9 -2.2 -0.2 0.8 -0.4 0.4 -1.2 -1.5 -0.6 -0.2
High blood pressure (siblings) 0.6 0.9 2.6 -1.2 0.7 -0.3 -0.2 -0.8 -0.9 -1.3 -1.6 0.0
Forced vital capacity (FVC), Best measure 0.5 1.7 3.5 -1.1 1.8 1.4 1.9 -1.2 1.5 1.2 0.0 0.4
Body fat percentage 0.3 1.2 3.5 -1.2 0.1 -1.3 1.9 -1.4 -0.8 -1.2 -0.4 -0.7
Leg fat percentage (right) 0.3 1.0 2.8 -1.0 -0.2 -1.5 1.7 -1.1 -0.6 -0.8 0.2 -0.7
Arm fat-free mass (right) 0.5 2.4 9.7 -1.5 0.9 -0.2 3.1 -0.8 2.0 1.0 0.6 1.8
Exposure to tobacco smoke outside home 0.6 0.8 2.8 -0.9 -1.7 0.7 0.8 1.5 -0.4 0.1 0.1 0.6
Comparative body size at age 10 0.5 1.4 9.2 -3.0 0.6 -0.2 1.3 0.1 0.2 -0.4 -0.3 0.9
Number of full brothers 0.7 0.9 2.1 0.9 -0.6 -0.8 -1.3 0.5 -1.5 -1.1 -0.7 -0.5
Worry too long after embarrassment 0.3 0.6 2.0 -0.6 1.4 -0.9 0.5 -1.0 0.7 -0.0 0.6 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.0 -1.4 0.8 -1.0 0.3 -0.9 0.6 1.1 0.9 -0.8
Wheeze or whistling in the chest in last year 0.7 1.3 5.6 0.9 1.3 -0.0 2.4 -0.1 0.1 -0.1 -1.2 1.3
Number of children fathered 0.9 1.0 1.9 0.9 1.4 -1.1 0.6 -0.7 1.2 0.7 0.9 1.1
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 2.4 1.5 1.4 -0.4 0.9 -0.2 1.1 0.9 -0.8 1.5
Age at first live birth 0.1 0.2 0.5 0.4 0.1 0.7 0.6 -0.3 0.6 0.4 0.6 -0.2
Pulse wave peak to peak time 0.8 0.9 2.2 -0.3 -0.6 0.5 1.2 0.4 1.5 1.4 0.7 1.0
Health satisfaction 0.8 1.0 5.6 -2.4 0.8 -0.1 1.0 -1.3 -0.0 -0.3 0.1 -0.2
Shortness of breath walking on level ground 1.1 1.3 3.0 -1.7 0.3 -1.6 0.8 -1.4 -0.4 -1.1 0.8 -1.2
Qualifications: College or University degree 0.2 0.5 1.0 0.9 0.6 1.0 -0.5 -0.6 1.0 0.5 0.2 0.6
Eye problems/disorders: None of the above 1.0 1.1 2.7 -0.9 -1.0 -1.0 -1.6 0.4 -1.6 -0.8 -0.7 -0.9
Mouth/teeth dental problems: Loose teeth 1.3 1.6 6.6 1.2 -1.0 -0.5 -0.4 2.6 -0.1 0.8 1.9 0.4
Emphysema/chronic bronchitis 0.9 1.0 2.1 0.2 -0.8 1.3 1.4 0.1 -1.4 -0.8 -1.3 -0.5
Medication for pain relief, constipation, heartburn 1.3 2.2 5.0 1.6 0.9 1.6 1.3 0.1 2.2 1.9 0.5 1.7
Neck or shoulder pain in last month 0.6 0.8 2.0 -0.3 -1.4 1.0 -0.6 0.8 -0.5 0.9 0.9 -1.3
Medication: Blood pressure 0.5 0.8 2.3 -0.6 0.5 -1.5 -1.3 -0.7 -0.4 0.0 -1.4 0.3
Angina (self-reported) 1.0 1.4 4.3 1.7 1.1 -1.2 2.1 -1.4 0.5 -0.1 -0.5 -0.0
Migraine (self-reported) 1.6 1.9 5.2 0.1 1.3 1.7 1.1 -2.0 1.1 0.4 -2.3 1.0
Medication: Ibuprofen 2.0 2.3 6.6 1.1 2.1 -0.1 1.2 0.8 1.9 0.7 1.6 2.6
Medication: Allopurinol 0.4 0.5 1.8 -0.8 0.0 -0.4 0.2 -1.0 -0.7 0.0 -1.3 -0.4
Medication: Omeprazole 0.9 1.1 2.7 -0.0 0.3 -0.7 1.0 -1.6 -1.0 -1.6 -0.3 -1.3
Medication: Seretide 50 evohaler 0.6 0.7 1.7 -0.6 0.2 -1.1 -1.3 -0.1 -0.7 -1.3 -0.9 0.0
Mean time to correctly identify matches 0.4 0.8 2.2 0.5 -0.5 0.6 -0.7 1.5 0.4 1.0 -0.2 1.5
Heart disease (mother) 0.8 0.9 2.6 -0.4 -0.3 1.5 -0.8 1.6 -0.5 -0.1 -0.9 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 7.9 0.3 -0.8 -1.3 1.1 1.4 -0.3 0.3 2.8 -1.2
Whole body fat mass 0.3 1.2 4.9 -1.7 0.2 -1.1 2.2 -1.3 0.0 -0.5 -0.2 -0.0
Leg fat mass (right) 0.3 1.1 5.5 -1.3 0.2 -1.2 2.3 -1.2 0.2 -0.4 0.2 0.1
Arm predicted mass (right) 0.5 2.5 10.4 -1.5 1.1 -0.2 3.2 -0.7 1.9 0.9 0.6 1.8
Pulse rate, automated reading 0.1 0.2 0.8 -0.9 0.0 0.6 0.2 0.0 -0.2 -0.8 0.5 -0.1
Alcohol intake frequency. 0.4 1.0 1.9 -0.8 -1.2 -1.1 -1.4 1.4 -0.8 0.6 0.3 -0.7
Comparative height size at age 10 0.2 1.3 2.6 0.2 1.6 -1.5 1.6 -1.5 0.8 -0.4 1.2 -0.4
Number of full sisters 0.4 0.5 1.3 0.2 -0.8 -0.4 -1.1 -0.1 -0.8 -0.8 -0.2 -0.8
Suffer from ‘nerves’ 0.4 0.6 1.3 0.5 -0.6 1.1 -1.1 -0.1 0.5 0.1 -1.1 1.0
Overall health rating 0.1 0.1 0.7 -0.8 -0.1 -0.3 0.3 0.0 -0.4 -0.0 -0.2 -0.0
Chest pain or discomfort 1.1 1.6 6.1 0.0 1.2 -2.0 0.8 -2.5 -0.1 0.0 -0.2 -1.5
Had major operations 0.7 0.8 2.4 0.1 -1.4 -1.6 0.0 -0.0 -0.8 0.2 0.5 -1.3
Age at last live birth 0.8 1.2 4.7 2.2 -0.9 1.1 -0.5 0.9 0.3 1.0 1.3 -0.4
Family relationship satisfaction 0.6 0.7 2.6 -0.3 -1.6 0.6 0.1 1.1 0.2 0.8 1.2 -0.0
Leg pain on walking 0.6 0.8 2.8 -1.7 -0.2 -0.4 1.1 -1.0 -0.2 -0.3 0.4 -1.1
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 3.5 -1.1 -1.2 -1.9 -0.8 -0.4 -1.1 -1.8 -0.8 -0.6
Commuting to job workplace: Car/motor vehicle 1.7 1.9 7.3 -0.8 -2.7 -1.1 0.8 1.6 -0.8 -0.6 1.6 -1.1
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 2.4 0.6 1.2 1.2 0.8 -0.9 0.0 -0.4 -1.6 0.7
Medication: Aspirin 0.6 0.8 2.3 0.0 0.6 -0.0 0.3 -1.5 -0.3 -1.5 -1.4 -0.0
Supplements: Vitamin C 0.5 0.6 1.9 -0.8 -0.9 -0.3 -1.4 -0.2 -0.7 -0.5 -0.0 -1.0
Knee pain experienced in last month 1.1 1.7 9.2 -0.9 -1.3 0.5 0.2 1.6 0.3 0.4 3.0 -0.5
Hypertension (Self-reported) 0.5 1.5 4.3 -1.3 0.4 -1.0 -1.4 -1.8 -0.7 0.2 -2.1 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.2 3.8 10.5 -0.8 1.6 -1.2 0.9 -3.2 -1.7 -2.4 -2.4 -2.0
Illnesses of father: Heart disease 0.9 1.2 4.6 -0.8 -1.8 1.3 0.0 2.1 -0.7 0.5 0.0 -0.4
Illnesses of siblings: Diabetes 0.1 0.2 0.7 -0.1 0.5 -0.2 0.8 -0.4 0.3 0.4 -0.2 0.0
Smoking status: Previous 0.5 0.8 3.5 0.9 -0.5 0.6 -0.2 -0.6 1.2 1.9 -0.1 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.3 1.0 -0.1 -1.2 0.4 -0.2 0.4 -1.0 0.7 0.6
Whole body fat-free mass 0.4 2.2 6.1 -1.7 0.7 -0.2 2.5 -0.3 2.0 0.9 0.7 2.1
Leg fat-free mass (right) 0.3 1.6 4.5 -2.1 0.3 0.1 1.7 -0.1 1.5 0.9 0.0 2.0
Arm fat percentage (left) 0.2 1.0 4.5 -2.1 -0.8 -0.8 0.7 -0.4 -1.0 -0.9 -0.5 -0.5
Average weekly red wine intake 0.4 0.6 2.4 1.0 -0.1 0.4 -0.4 0.1 -0.9 -0.7 -1.5 0.4
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.4 1.2 -0.2 -0.8 -0.7 0.4 -0.2 1.1 0.1 -0.4
Mood swings 0.4 0.7 2.2 -1.5 1.2 -0.1 0.3 -1.4 0.3 0.1 -0.9 0.4
Loneliness, isolation 0.7 1.0 4.9 -2.2 1.3 -0.3 0.3 -1.2 0.1 0.3 -0.4 -0.3
Long-standing illness, disability or infirmity 1.1 1.6 7.0 -2.6 0.3 -1.3 0.5 -1.3 -0.6 -0.6 0.5 -1.7
Ever had bowel cancer screening 1.1 1.3 3.6 -1.0 1.1 -0.4 1.9 -1.9 0.5 1.0 -0.2 -1.1
Diabetes diagnosed by doctor 0.3 0.5 1.2 1.1 -0.9 -0.0 -0.5 -0.4 -1.0 -0.7 -0.5 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 2.3 0.5 1.0 -0.6 0.6 -0.1 1.5 1.4 0.7 1.0
Friendships satisfaction 0.5 0.6 2.6 -1.1 -0.3 -0.5 1.6 -0.4 0.8 0.6 0.3 0.3
Qualifications: nursing, teaching 0.2 0.3 1.6 0.3 -1.3 -0.6 -0.2 -0.0 -0.4 -0.6 0.2 -0.6
Commuting to job workplace: Walk 1.0 1.1 3.0 1.7 -0.5 1.2 -1.7 0.3 0.4 0.1 -0.9 1.2
Eye problems/disorders: Cataract 1.2 1.3 3.6 1.3 -0.1 1.4 1.1 0.5 1.6 1.9 0.6 0.7
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.0 0.3 0.0 0.6 1.0 -0.3 0.1 0.6 -1.0 0.3
Medication for cholesterol 1.7 2.6 7.2 1.5 -0.4 1.5 1.1 2.7 1.1 1.7 1.3 2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 3.8 -0.1 1.9 -0.7 0.4 -1.9 1.0 0.8 -0.1 -0.0
Back pain experienced in last month 0.9 1.2 2.7 -1.4 -1.1 -1.6 -1.6 -0.4 -1.0 -0.7 0.2 -1.1
Mineral and other dietary supplements 0.7 0.9 3.1 -0.4 0.8 -0.6 0.8 -1.4 -0.5 -0.8 0.4 -1.8
Breast cancer (self-reported) 0.8 1.0 4.1 -2.0 -0.1 0.3 -0.9 1.2 0.6 0.6 0.6 1.2
Asthma (self-reported) 0.8 1.7 5.5 -1.3 -0.1 -1.0 -0.3 -0.3 -2.0 -1.2 -1.0 -2.4
Osteoporosis (self-reported) 0.9 1.1 5.9 2.4 0.3 -0.4 0.5 -0.8 0.7 1.4 -0.0 0.2
Osteoarthritis (self-reported) 1.2 1.5 5.3 -1.4 -1.5 -0.9 -0.4 0.3 -0.5 -0.3 2.3 -1.6
Medication: Aspirin 0.7 1.0 3.5 0.1 0.5 -0.4 -0.3 -1.2 -1.0 -1.9 -1.4 -0.4
Medication: Gliclazide 0.5 0.6 1.7 -0.1 -0.4 -1.2 0.1 -0.8 0.0 0.4 0.9 -1.3
Illnesses of father: None of the above (group 1) 0.4 0.4 1.0 -0.6 -0.4 -1.0 -0.6 -0.6 -0.6 -0.7 0.1 -0.9
Smoking status: Current 0.5 0.8 4.6 0.5 -2.2 0.7 -0.7 0.6 -0.4 0.2 -0.2 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 6.0 -2.4 1.2 0.2 -0.6 -2.4 -0.5 -0.7 -1.3 -0.8
Whole body water mass 0.4 2.1 5.6 -1.8 0.7 -0.2 2.4 -0.3 2.0 0.9 0.6 2.1
Leg predicted mass (right) 0.3 1.6 4.5 -2.1 0.3 0.0 1.8 -0.1 1.5 0.9 0.0 2.0
Arm fat mass (left) 0.3 1.0 5.8 -2.4 -0.1 -0.8 1.4 -0.8 0.1 -0.4 -0.1 0.4
Number of self-reported non-cancer illnesses 2.4 4.2 11.6 -2.2 -0.0 -0.6 -1.5 -2.7 -2.5 -1.3 -1.8 -3.4
Average weekly champagne plus white wine intake 0.6 0.8 3.6 -0.6 1.1 -0.3 1.2 -1.9 0.5 -0.7 0.1 -0.5
Miserableness 0.5 0.8 2.4 -0.3 1.4 -0.0 1.5 -1.3 0.9 0.3 -0.3 0.7
Guilty feelings 0.9 1.3 3.4 1.1 -0.2 1.4 1.5 0.7 1.5 0.6 0.5 1.8
Wears glasses or contact lenses 0.8 0.9 4.2 0.6 2.1 -0.9 0.2 -1.5 0.4 0.1 -0.7 0.2
Ever taken oral contraceptive pill 0.4 0.5 2.0 -1.4 0.5 0.1 0.7 0.3 0.4 0.2 0.5 0.9
Hearing aid user 1.7 1.9 4.9 -1.8 -0.9 -1.9 0.2 -1.9 -0.5 -0.2 0.7 -2.2
Mother’s age at death 0.6 0.8 2.5 -0.4 -1.0 -0.9 0.8 0.5 0.2 0.9 1.6 -0.9
Financial situation satisfaction 1.4 1.7 4.0 -0.5 1.2 -0.2 1.6 -0.6 1.8 2.0 1.3 1.2
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.4 -1.1 0.6 -1.5 -0.4 -0.8 -0.5 -0.7 -1.2 0.1
Commuting to job workplace: Public transport 0.4 0.5 1.4 0.8 0.6 -0.5 -1.2 -0.2 -0.7 -1.1 0.2 -0.5
Eye problems/disorders: Glaucoma 0.7 0.9 3.5 0.0 0.8 -0.1 -0.6 -1.9 -0.7 -0.8 -1.2 -0.7
Medication: Blood pressure 1.1 2.1 5.0 -1.6 0.6 -1.6 -0.8 -2.2 -1.2 -1.2 -1.7 -1.6
Pain type(s) experienced in last month: Hip pain 1.1 1.4 3.6 0.2 -1.9 1.1 -0.2 1.6 -0.8 0.3 1.6 -1.2
Supplements: Fish oil (including cod liver oil) 1.0 1.3 3.7 -0.6 -1.6 0.6 -1.6 1.9 -0.5 0.6 -0.7 0.9
High cholesterol (Self-reported) 0.2 0.4 1.1 1.0 -0.3 -0.2 0.6 -0.9 -0.3 -0.5 -1.0 -0.2
Medication: Bendroflumethiazide 0.7 1.1 3.9 -0.3 2.0 -1.9 -0.5 -1.2 0.5 0.1 0.3 0.3
Medication: Paracetamol 1.0 1.6 4.8 -1.7 -1.3 -0.9 -1.2 0.4 -1.6 -0.2 0.1 -2.2
Medication: Lisinopril 3.6 4.7 16.3 -4.0 -1.0 -2.5 0.5 -2.0 -1.8 -1.8 -0.0 -2.9
Medication: Atorvastatin 1.3 1.6 4.1 1.9 1.4 0.3 2.0 -2.0 0.4 -0.1 -0.6 -0.4
Illnesses of father: High blood pressure 0.4 0.5 1.7 0.3 0.3 -0.6 0.1 -0.3 -1.3 -0.9 -0.6 -1.1
Alcohol drinker status: Never 0.6 0.8 2.2 0.5 0.1 -1.5 -1.1 1.4 -0.9 -0.6 0.0 0.4
Ever smoked 0.6 1.1 3.6 1.3 -0.6 0.9 -0.9 -0.5 0.5 1.2 -1.9 0.5
Basal metabolic rate 0.4 1.9 6.0 -2.0 0.6 -0.3 2.4 -0.5 1.7 0.6 0.5 1.8
Leg fat percentage (left) 0.4 1.3 3.2 -1.4 0.1 -1.8 1.7 -1.4 -0.5 -0.9 0.1 -0.7
Arm fat-free mass (left) 0.5 2.7 9.5 -2.0 1.2 -0.6 3.1 -1.1 2.0 0.7 0.6 1.8
Number of operations (self-reported) 0.6 0.9 3.4 -0.1 0.5 0.2 0.1 -1.8 0.0 1.0 -1.8 -0.6
Average weekly beer plus cider intake 2.3 3.3 7.4 -1.8 -1.9 -1.5 -2.7 -0.1 -2.2 -1.3 -2.1 -1.5
Irritability 0.5 0.9 2.5 1.4 -0.3 1.0 -1.0 0.2 0.6 0.0 -1.1 1.6
Risk taking 0.2 0.4 0.7 -0.5 -0.9 -0.8 0.0 0.4 -0.9 -0.5 0.1 -0.7
Ever had prostate specific antigen (PSA) test 0.8 0.9 3.2 1.7 0.1 -0.4 0.6 -0.0 1.1 0.5 1.8 0.0
Fractured/broken bones in last 5 years 1.3 1.7 4.2 1.4 -1.4 0.7 -0.7 1.0 1.2 2.1 2.1 -0.1
Age started oral contraceptive pill 2.7 3.4 9.1 -2.0 -0.7 -1.2 -1.9 -0.1 -3.0 -1.7 -0.2 -3.0
Diastolic blood pressure, automated reading 0.6 1.9 9.1 -3.0 -0.6 -0.2 -0.6 -0.9 -1.5 -0.1 -1.8 -1.2
Ever depressed for a whole week 1.8 2.2 4.8 1.6 2.2 0.1 1.8 -2.0 1.4 0.8 -1.1 1.2
Unable to work because of sickness or disability 0.8 1.1 2.8 -1.7 -0.8 1.6 0.9 -0.8 1.0 1.0 -0.5 0.3
Commuting to job workplace: Cycle 0.6 0.8 2.8 0.7 -0.1 -0.8 -1.7 1.2 0.3 -0.0 1.1 0.4
Myopia 0.8 1.2 4.9 -0.0 1.3 0.4 0.7 -0.8 0.6 0.4 -2.2 1.5
Vascular/heart problems diagnosed by doctor 0.4 1.2 2.5 1.4 -0.1 1.2 0.8 1.6 0.9 -0.0 1.5 1.2
Cholesterol lowering medication 0.5 0.7 3.2 0.7 0.5 -0.6 0.6 -1.8 0.1 -1.1 -0.0 -0.8
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 5.9 0.1 0.3 -1.1 1.1 -1.6 -1.4 -2.4 -0.3 -1.7
Pain experienced in last month 1.1 1.8 7.9 2.8 -0.1 0.7 0.0 1.3 -0.1 -1.1 -1.2 1.9
Supplements: Calcium 1.1 1.2 4.4 -0.6 -1.3 0.5 -2.1 1.5 -0.2 0.3 -1.0 0.9
Basal cell carcinoma (self-reported) 1.1 1.4 7.9 0.7 0.4 -0.0 -2.8 0.1 -0.4 -0.6 -1.5 0.9
Heart attack/myocardial infarction (self-reported) 1.4 1.8 5.8 2.4 0.8 0.7 1.2 0.9 1.5 1.6 0.7 1.4
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 3.1 1.0 -0.5 0.1 0.6 0.2 1.4 1.8 0.6 0.9
Heart disease (siblings) 1.1 1.4 4.5 1.4 -0.8 -1.0 -1.3 0.7 -1.4 0.1 -2.1 0.2
Alcohol drinker status: Previous 0.8 1.0 2.6 -1.6 -1.1 -0.2 -1.0 0.2 -1.1 -0.1 -0.4 -1.5
Pack years of smoking 1.4 2.0 6.0 -1.1 0.5 2.4 1.5 1.1 1.6 1.3 1.2 1.4
Impedance of whole body 0.5 2.4 11.0 3.3 1.0 -0.2 0.2 -1.0 -1.4 -1.3 -0.4 -2.2
Leg fat mass (left) 0.3 1.3 5.7 -1.7 0.3 -1.3 2.4 -1.3 0.2 -0.4 0.1 0.0
Arm predicted mass (left) 0.5 2.8 8.9 -1.9 1.1 -0.2 3.0 -0.7 2.2 1.0 0.9 2.0