[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr12:109,641,978-113,517,494

Best TWAS P=8.81e-71 · Best GWAS P=6.38e-117 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	GTEx	Artery Tibial	HECTD4	0.05	0.02	lasso	3	0.01	3.1e-02	18.94	17.8	8.8e-71	0.78	0.02	0.92	TRUE
4	GTEx	Adipose Subcutaneous	HECTD4	0.06	0.00	enet	15	0.02	1.0e-02	-7.90	15.7	2.9e-55	0.65	0.06	0.84	TRUE
46	GTEx	Heart Left Ventricle	ADAM1A	0.20	0.07	enet	22	0.10	4.3e-06	-3.54	-10.2	1.4e-24	-0.34	0.35	0.15	TRUE
18	GTEx	Brain Cerebellar Hemisphere	ADAM1A	0.21	0.01	enet	29	0.03	6.8e-02	-3.96	8.6	5.5e-18	0.39	0.04	0.16	TRUE
28	GTEx	Breast Mammary Tissue (Female)	VPS29	0.10	-0.01	lasso	2	0.02	1.0e-01	10.28	-8.4	5.6e-17	-0.34	0.03	0.19	TRUE
40	GTEx	Esophagus Gastroesophageal Junction	AC003029.1	0.06	0.03	lasso	3	0.04	1.9e-02	-7.47	-8.0	8.6e-16	-0.38	0.15	0.09	TRUE
91	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ALDH2	0.10	0.08	blup	30	0.09	4.5e-06	-8.03	6.9	7.1e-12	0.36	0.72	0.09	TRUE
23	GTEx	Brain Frontal Cortex BA9	ADAM1A	0.48	0.12	enet	30	0.26	1.4e-07	-3.59	-5.7	1.3e-08	-0.19	0.12	0.05	TRUE
80	YFS	Blood	ALDH2	0.36	0.07	enet	47	0.10	1.8e-32	-11.94	-5.2	1.6e-07	-0.18	1.00	0.00	TRUE
81	YFS	Blood	SH2B3	0.05	0.01	enet	22	0.02	3.3e-07	-9.58	16.1	2.5e-58	0.64	0.77	0.23	FALSE
60	GTEx	Skin Sun Exposed Lower leg	ALDH2	0.10	0.09	enet	13	0.13	6.7e-11	-8.02	14.0	1.6e-44	0.62	0.98	0.02	FALSE
83	YFS	Blood	TRAFD1	0.04	0.02	lasso	2	0.01	2.9e-05	11.00	13.5	2.4e-41	0.55	0.09	0.85	FALSE
101	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ERP29	0.11	0.03	blup	25	0.05	5.0e-03	-7.87	-12.7	7.0e-37	-0.60	0.01	0.75	FALSE
70	GTEx	Thyroid	BRAP	0.07	0.02	lasso	7	0.03	1.1e-03	-9.58	-12.6	1.6e-36	-0.54	0.41	0.34	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ATXN2	0.02	0.03	enet	8	0.02	4.8e-04	-9.21	12.3	1.6e-34	0.56	0.28	0.61	FALSE
93	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACAD10	0.02	0.02	lasso	3	0.01	7.0e-03	-12.17	-12.2	4.0e-34	-0.50	0.00	0.91	FALSE
58	GTEx	Skin Not Sun Exposed Suprapubic	MAPKAPK5-AS1	0.04	0.00	enet	30	0.00	7.0e-01	-7.83	-11.3	1.6e-29	-0.53	0.20	0.18	FALSE
86	The Cancer Genome Atlas	Colon Adenocarcinoma	ALDH2	0.07	0.03	lasso	4	0.06	3.9e-04	-6.37	10.9	7.6e-28	0.44	0.02	0.91	FALSE
79	YFS	Blood	ACAD10	0.07	0.01	bslmm	241	0.02	4.3e-08	-9.85	-10.1	4.6e-24	-0.41	0.09	0.40	FALSE
77	NTR	Blood	ALDH2	0.06	0.01	blup	222	0.02	4.3e-08	-5.10	-10.1	4.7e-24	-0.43	0.99	0.00	FALSE
71	GTEx	Thyroid	ALDH2	0.06	0.04	lasso	4	0.05	9.7e-05	-9.58	9.9	3.8e-23	0.47	0.87	0.07	FALSE
6	GTEx	Adipose Subcutaneous	AC003029.1	0.08	0.07	enet	30	0.05	1.2e-04	-7.89	-9.9	4.3e-23	-0.47	1.00	0.00	FALSE
51	GTEx	Nerve Tibial	HECTD4	0.05	0.01	enet	6	0.01	3.6e-02	-9.85	9.8	1.7e-22	0.41	0.22	0.46	FALSE
10	GTEx	Artery Aorta	AC003029.1	0.07	0.01	lasso	7	0.01	5.4e-02	-9.58	-9.6	1.1e-21	-0.43	0.20	0.28	FALSE
66	GTEx	Testis	MAPKAPK5	0.23	0.12	lasso	5	0.15	3.1e-07	-6.86	9.5	1.4e-21	0.41	0.72	0.22	FALSE
37	GTEx	Colon Transverse	FAM109A	0.21	0.00	lasso	4	0.01	1.3e-01	-10.34	9.4	3.7e-21	0.41	0.06	0.06	FALSE
21	GTEx	Brain Frontal Cortex BA9	ALDH2	0.33	0.04	enet	24	0.09	2.0e-03	-8.45	9.4	4.7e-21	0.33	0.09	0.08	FALSE
5	GTEx	Adipose Subcutaneous	MAPKAPK5-AS1	0.08	0.01	enet	26	0.03	2.1e-03	-9.61	-9.2	2.5e-20	-0.44	0.98	0.01	FALSE
55	GTEx	Pituitary	RP3-462E2.5	0.15	0.12	lasso	3	0.14	2.3e-04	-7.90	9.1	6.5e-20	0.43	0.23	0.05	FALSE
41	GTEx	Esophagus Mucosa	ALDH2	0.05	0.06	lasso	6	0.07	1.7e-05	-8.00	9.1	7.1e-20	0.43	0.92	0.04	FALSE
64	GTEx	Stomach	TMEM116	0.13	0.03	lasso	7	0.03	1.6e-02	-3.60	-9.0	2.0e-19	-0.46	0.07	0.15	FALSE
27	GTEx	Breast Mammary Tissue (Male)	RP3-462E2.3	0.12	0.03	lasso	7	0.04	4.0e-02	-5.48	-9.0	2.5e-19	-0.39	0.02	0.06	FALSE
42	GTEx	Esophagus Muscularis	HECTD4	0.06	0.03	lasso	4	0.02	1.8e-02	-8.00	8.8	9.6e-19	0.41	0.57	0.07	FALSE
20	GTEx	Brain Cerebellum	HECTD4	0.25	-0.01	enet	24	0.06	7.7e-03	-2.09	8.8	1.2e-18	0.42	0.06	0.72	FALSE
13	GTEx	Artery Tibial	ALDH2	0.08	0.09	lasso	2	0.07	2.7e-06	-7.90	8.7	4.4e-18	0.41	0.95	0.02	FALSE
95	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAPKAPK5	0.03	0.01	blup	42	0.01	2.5e-02	-6.86	8.6	8.6e-18	0.37	0.05	0.48	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ALDH2	0.05	0.11	blup	223	0.10	1.8e-12	-8.02	8.6	1.1e-17	0.42	1.00	0.00	FALSE
76	METSIM	Adipose	ALDH2	0.07	0.00	bslmm	220	0.02	2.5e-04	-6.86	8.5	1.6e-17	0.32	0.16	0.04	FALSE
67	GTEx	Testis	BRAP	0.06	0.03	enet	13	0.01	8.7e-02	-8.00	-8.5	2.2e-17	-0.41	0.43	0.08	FALSE
47	GTEx	Lung	ALDH2	0.07	0.01	lasso	10	0.02	5.9e-03	-7.91	8.5	2.5e-17	0.39	0.38	0.04	FALSE
9	GTEx	Artery Aorta	ALDH2	0.05	0.04	enet	33	0.05	1.3e-03	-6.86	8.4	3.4e-17	0.38	0.59	0.10	FALSE
57	GTEx	Skin Not Sun Exposed Suprapubic	ALDH2	0.13	0.18	lasso	9	0.16	5.0e-09	-7.81	8.3	1.2e-16	0.40	1.00	0.00	FALSE
11	GTEx	Artery Coronary	MAPKAPK5-AS1	0.16	0.10	lasso	13	0.06	5.7e-03	-7.81	-8.1	5.3e-16	-0.38	0.39	0.06	FALSE
50	GTEx	Nerve Tibial	ALDH2	0.05	0.04	lasso	3	0.05	2.4e-04	-8.00	8.1	6.8e-16	0.39	0.76	0.02	FALSE
43	GTEx	Esophagus Muscularis	MAPKAPK5-AS1	0.04	0.02	enet	7	0.02	2.7e-02	-7.96	-8.1	7.9e-16	-0.39	0.35	0.03	FALSE
96	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM116	0.03	0.03	blup	43	0.03	8.0e-05	-4.10	-8.1	8.4e-16	-0.43	0.52	0.21	FALSE
62	GTEx	Skin Sun Exposed Lower leg	AC003029.1	0.09	0.10	lasso	2	0.10	8.8e-09	-7.99	-8.1	8.6e-16	-0.39	1.00	0.00	FALSE
8	GTEx	Adrenal Gland	AC003029.1	0.12	0.10	lasso	13	0.07	2.0e-03	-8.00	-8.0	9.0e-16	-0.39	0.80	0.03	FALSE
94	The Cancer Genome Atlas	Brain Lower Grade Glioma	ALDH2	0.03	0.03	lasso	1	0.03	3.1e-04	-8.02	8.0	1.0e-15	0.38	0.04	0.49	FALSE
73	GTEx	Thyroid	AC003029.1	0.04	0.05	lasso	3	0.04	8.3e-04	-7.81	-8.0	1.5e-15	-0.39	0.81	0.04	FALSE
53	GTEx	Nerve Tibial	RP3-462E2.3	0.12	0.03	lasso	7	0.03	2.7e-03	-6.37	-7.9	2.0e-15	-0.32	0.93	0.00	FALSE
61	GTEx	Skin Sun Exposed Lower leg	MAPKAPK5-AS1	0.09	0.10	lasso	4	0.10	1.1e-08	-7.89	-7.9	2.3e-15	-0.39	1.00	0.00	FALSE
7	GTEx	Adrenal Gland	MAPKAPK5-AS1	0.10	0.08	lasso	12	0.03	3.0e-02	-8.00	-7.9	2.8e-15	-0.39	0.56	0.06	FALSE
39	GTEx	Colon Transverse	AC003029.1	0.15	0.09	lasso	12	0.07	2.1e-04	-7.83	-7.9	3.2e-15	-0.39	0.81	0.02	FALSE
38	GTEx	Colon Transverse	MAPKAPK5-AS1	0.16	0.09	lasso	13	0.06	7.1e-04	-7.81	-7.9	3.9e-15	-0.39	0.82	0.02	FALSE
72	GTEx	Thyroid	MAPKAPK5-AS1	0.04	0.04	lasso	2	0.03	1.5e-03	-7.81	-7.8	4.5e-15	-0.38	0.62	0.02	FALSE
68	GTEx	Testis	MAPKAPK5-AS1	0.07	0.04	lasso	1	0.03	1.3e-02	-7.83	-7.8	4.9e-15	-0.38	0.19	0.13	FALSE
24	GTEx	Brain Putamen basal ganglia	ALDH2	0.12	0.00	lasso	14	0.02	1.3e-01	-8.22	7.8	5.7e-15	0.39	0.17	0.13	FALSE
26	GTEx	Breast Mammary Tissue	HECTD4	0.06	0.08	lasso	1	0.07	1.6e-04	-7.81	7.8	5.8e-15	0.38	0.32	0.19	FALSE
33	GTEx	Cells Transformed fibroblasts	AC003029.1	0.06	0.05	lasso	1	0.03	2.1e-03	-7.81	-7.8	5.8e-15	-0.38	0.66	0.02	FALSE
29	GTEx	Breast Mammary Tissue (Female)	HECTD4	0.06	-0.01	lasso	2	0.01	1.2e-01	-7.81	7.7	1.2e-14	0.35	0.05	0.26	FALSE
32	GTEx	Cells Transformed fibroblasts	MAPKAPK5-AS1	0.06	0.04	lasso	12	0.02	9.5e-03	-7.81	-7.7	1.5e-14	-0.38	0.53	0.04	FALSE
100	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ALDH2	0.08	0.08	blup	32	0.09	2.3e-04	-7.81	7.7	1.8e-14	0.37	0.18	0.41	FALSE
84	The Cancer Genome Atlas	Breast Invasive Carcinoma	C12orf47	0.01	0.01	blup	31	0.01	7.3e-03	-7.83	-7.5	4.2e-14	-0.38	0.08	0.04	FALSE
12	GTEx	Artery Coronary	AC003029.1	0.14	0.12	enet	39	0.07	1.8e-03	-7.81	-7.5	4.3e-14	-0.34	0.62	0.04	FALSE
69	GTEx	Testis	AC003029.1	0.10	0.10	lasso	14	0.09	5.8e-05	-7.83	-7.5	5.9e-14	-0.38	0.64	0.12	FALSE
16	GTEx	Artery Tibial	AC003029.1	0.05	0.04	lasso	12	0.03	3.6e-03	-7.83	-7.4	1.3e-13	-0.38	0.58	0.04	FALSE
52	GTEx	Nerve Tibial	AC003029.1	0.04	0.00	lasso	23	0.00	4.2e-01	-4.09	-7.4	1.9e-13	-0.38	0.18	0.05	FALSE
98	The Cancer Genome Atlas	Lung Adenocarcinoma	C12orf47	0.02	0.01	blup	31	0.02	1.7e-03	-7.81	-7.3	2.5e-13	-0.36	0.14	0.08	FALSE
82	YFS	Blood	TCTN1	0.05	0.00	bslmm	204	0.02	3.1e-06	0.70	-7.3	2.6e-13	-0.21	0.25	0.64	FALSE
97	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TMEM116	0.04	0.02	blup	43	0.02	3.5e-02	-4.12	-7.2	4.5e-13	-0.39	0.03	0.12	FALSE
85	The Cancer Genome Atlas	Breast Invasive Carcinoma	MAPKAPK5	0.04	0.02	lasso	4	0.02	5.4e-05	-6.86	7.2	4.6e-13	0.28	0.54	0.26	FALSE
45	GTEx	Heart Atrial Appendage	ALDH2	0.16	0.14	lasso	3	0.10	2.4e-05	-6.69	7.2	5.0e-13	0.28	0.52	0.04	FALSE
48	GTEx	Lung	RP3-462E2.3	0.11	0.10	lasso	6	0.09	2.2e-07	-6.86	-7.2	5.2e-13	-0.29	1.00	0.00	FALSE
87	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C12orf47	0.03	0.03	lasso	3	0.03	6.3e-04	-6.37	-7.2	7.0e-13	-0.29	0.16	0.10	FALSE
89	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C12orf47	0.07	0.04	lasso	2	0.03	1.0e-04	-7.91	-7.2	8.5e-13	-0.36	0.18	0.77	FALSE
65	GTEx	Stomach	AC003029.1	0.10	0.03	enet	32	0.02	2.6e-02	-7.81	-7.0	2.1e-12	-0.34	0.47	0.08	FALSE
34	GTEx	Colon Sigmoid	MAPKAPK5-AS1	0.17	0.05	lasso	15	0.07	1.5e-03	-7.81	-7.0	2.4e-12	-0.37	0.51	0.06	FALSE
49	GTEx	Muscle Skeletal	MAPKAPK5	0.08	0.04	lasso	7	0.02	3.6e-03	-6.37	7.0	2.4e-12	0.28	0.79	0.01	FALSE
25	GTEx	Breast Mammary Tissue	VPS29	0.20	0.03	enet	33	0.08	5.2e-05	10.28	-6.9	4.4e-12	-0.25	0.05	0.76	FALSE
63	GTEx	Skin Sun Exposed Lower leg	RP3-462E2.3	0.06	0.05	lasso	6	0.05	1.0e-04	-6.86	-6.9	7.0e-12	-0.27	0.41	0.02	FALSE
90	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAPKAPK5	0.06	0.03	lasso	3	0.03	6.5e-04	-6.86	6.8	8.1e-12	0.26	0.24	0.08	FALSE
103	The Cancer Genome Atlas	Prostate Adenocarcinoma	ALDH2	0.02	0.02	blup	31	0.01	1.2e-02	-7.81	6.8	1.5e-11	0.35	0.06	0.06	FALSE
22	GTEx	Brain Frontal Cortex BA9	TMEM116	0.10	0.09	lasso	7	0.18	1.9e-05	-7.91	-6.5	7.4e-11	-0.36	0.38	0.04	FALSE
36	GTEx	Colon Transverse	VPS29	0.13	0.01	enet	41	0.10	2.0e-05	-0.91	-6.5	8.1e-11	-0.12	0.08	0.18	FALSE
30	GTEx	Breast Mammary Tissue (Female)	RP3-462E2.3	0.13	0.00	lasso	5	-0.01	7.8e-01	-6.37	-6.5	9.1e-11	-0.24	0.04	0.05	FALSE
105	The Cancer Genome Atlas	Thyroid Carcinoma	ALDH2	0.03	0.02	blup	31	0.02	6.4e-03	-7.88	6.5	9.4e-11	0.32	0.08	0.12	FALSE
99	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM116	0.12	0.07	blup	43	0.10	7.6e-05	-4.09	-6.4	1.2e-10	-0.37	0.36	0.21	FALSE
35	GTEx	Colon Sigmoid	AC003029.1	0.17	0.08	lasso	14	0.09	3.8e-04	-7.81	-6.4	1.8e-10	-0.35	0.60	0.07	FALSE
75	GTEx	Whole Blood	RP3-462E2.3	0.07	0.05	lasso	4	0.03	1.7e-03	-6.37	-6.4	1.8e-10	-0.24	0.65	0.01	FALSE
19	GTEx	Brain Cerebellum	NAA25	0.12	-0.01	lasso	12	0.00	3.0e-01	-3.60	-6.3	2.1e-10	-0.34	0.12	0.07	FALSE
54	GTEx	Pituitary	ADAM1A	0.18	0.22	enet	42	0.20	9.6e-06	-3.59	6.2	5.1e-10	0.35	0.80	0.04	FALSE
31	GTEx	Cells Transformed fibroblasts	HECTD4	0.04	0.01	lasso	5	0.00	4.5e-01	-3.54	6.2	5.2e-10	0.35	0.22	0.04	FALSE
78	NTR	Blood	TCHP	0.01	0.00	lasso	2	0.00	2.6e-02	-5.29	-6.0	1.9e-09	-0.13	0.02	0.80	FALSE
17	GTEx	Brain Cerebellar Hemisphere	NAA25	0.11	0.02	enet	10	0.00	2.5e-01	-3.51	-6.0	2.1e-09	-0.33	0.14	0.06	FALSE
15	GTEx	Artery Tibial	MAPKAPK5-AS1	0.07	0.05	lasso	11	0.05	9.7e-05	-4.06	-5.7	1.2e-08	-0.33	0.76	0.02	FALSE
88	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ALDH2	0.10	0.00	enet	6	0.00	2.6e-01	5.25	5.7	1.2e-08	0.22	0.01	0.12	FALSE
3	CommonMind	Brain Pre-frontal Cortex	NAA25	0.03	0.02	blup	213	0.03	1.1e-04	-4.12	-5.6	2.7e-08	-0.33	0.74	0.02	FALSE
102	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TMEM116	0.17	0.06	blup	43	0.05	5.6e-03	-4.12	-5.5	2.9e-08	-0.34	0.09	0.20	FALSE
56	GTEx	Prostate	ADAM1A	0.30	0.11	lasso	16	0.12	5.4e-04	-4.12	5.5	3.7e-08	0.34	0.50	0.22	FALSE
59	GTEx	Skin Not Sun Exposed Suprapubic	RP3-462E2.3	0.31	0.20	lasso	7	0.19	1.7e-10	-6.37	-5.5	4.5e-08	-0.22	1.00	0.00	FALSE
92	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM116	0.04	0.04	enet	13	0.04	2.7e-03	-3.60	-5.4	7.1e-08	-0.31	0.05	0.12	FALSE
44	GTEx	Esophagus Muscularis	RP3-462E2.5	0.06	0.04	lasso	14	0.03	4.6e-03	-4.12	5.3	1.1e-07	0.32	0.75	0.02	FALSE
104	The Cancer Genome Atlas	Prostate Adenocarcinoma	C12orf47	0.04	0.03	blup	31	0.02	2.8e-03	-7.81	-5.2	1.7e-07	-0.30	0.13	0.06	FALSE
74	GTEx	Whole Blood	ADAM1A	0.08	0.02	lasso	10	0.01	2.7e-02	-4.12	5.1	2.9e-07	0.31	0.34	0.35	FALSE