TWAS hub - RBMS2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0930	0.0340	2.8e-04	0.044	0.021	0.013	0.015	-0.001	4.4e-06	1.3e-03	8.1e-03	5.0e-03	4.1e-01
2	GTEx	Brain Cerebellar Hemisphere	0.2480	0.0890	1.8e-03	-0.007	NA	-0.012	NA	-0.012	5.5e-01	NA	9.8e-01	NA	9.5e-01
3	GTEx	Brain Cerebellum	0.2480	0.0890	7.7e-04	0.049	NA	0.009	NA	0.145	1.4e-02	NA	1.7e-01	NA	4.6e-05
4	GTEx	Esophagus Mucosa	0.1970	0.0500	1.7e-07	0.150	NA	0.200	NA	0.112	3.0e-10	NA	2.1e-13	NA	6.9e-08
5	GTEx	Pancreas	0.0990	0.0420	6.1e-03	0.017	NA	-0.007	NA	0.004	5.9e-02	NA	8.4e-01	NA	2.2e-01
6	GTEx	Whole Blood	0.1590	0.0390	2.8e-08	0.150	NA	0.150	NA	0.047	1.0e-13	NA	1.0e-13	NA	3.3e-05
7	METSIM	Adipose	0.0982	0.0311	7.2e-07	0.065	0.062	0.049	0.063	0.057	4.7e-10	1.5e-09	6.9e-08	1.1e-09	5.9e-09
8	YFS	Blood	0.4664	0.0371	0.0e+00	0.255	0.420	0.484	0.300	0.369	6.1e-83	2.2e-151	2.0e-183	4.2e-100	1.6e-128
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0602	0.0276	1.1e-06	0.044	0.047	0.053	NA	0.045	9.8e-06	5.2e-06	1.2e-06	NA	7.3e-06
10	TCGA	Pheochromocytoma and Paraganglioma	0.1530	0.0700	1.4e-03	0.084	0.033	0.023	NA	0.029	3.1e-04	1.9e-02	4.3e-02	NA	2.4e-02
11	TCGA	Stomach Adenocarcinoma	0.0480	0.0280	9.6e-03	0.047	0.020	0.027	NA	0.029	2.5e-04	1.2e-02	4.8e-03	NA	3.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Blood Platelet Count	7.2	83.5	320.4	-8.4	7.4	14.2	-4.5	2.4	-1.8	0.5	12.9	-3.2	8.1	-17.9
Maternal smoking around birth	4.6	6.7	14.9	3.0	-0.1	0.9	3.0	1.9	3.3	2.3	3.5	2.6	3.9	-0.9
Illnesses of siblings: Diabetes	4.5	5.6	11.6	-2.5	-0.7	-0.8	-3.0	-1.4	-3.4	-3.0	-2.1	-2.7	-2.8	-1.8
Unable to work because of sickness or disability	3.6	4.7	12.4	-2.1	-0.3	-0.0	-3.5	-0.7	-2.6	-2.3	-1.3	-3.0	-2.4	-2.5
Hayfever/allergic rhinitis (self-reported)	3.5	4.6	10.8	-1.1	3.3	2.6	-2.3	1.7	-2.7	-2.0	-0.0	-2.5	-1.6	-1.8
Number of self-reported non-cancer illnesses	3.5	6.1	16.5	-2.2	1.2	1.2	-3.0	0.8	-2.5	-3.2	0.1	-3.6	-1.8	-4.1
Blood Red Count	3.3	31.5	77.1	-3.6	-8.8	-5.6	-4.8	-8.8	-6.0	-4.3	-6.1	-3.0	-4.9	-0.3
High cholesterol (Self-reported)	3.3	5.9	16.0	-2.8	-2.3	-0.1	-3.6	-0.7	-2.2	-2.4	-0.1	-4.0	-1.5	-3.0
Forced vital capacity (FVC), Best measure	3.2	11.6	30.6	5.2	3.4	-1.5	3.7	5.5	4.4	1.6	1.5	2.8	2.4	2.4
Angina	3.1	4.0	10.3	-3.2	-0.1	0.4	-2.2	-2.1	-3.1	-1.3	-1.6	-1.9	-2.0	-1.7
Angina (self-reported)	3.0	4.0	11.2	-3.4	0.2	0.6	-2.2	-2.1	-3.1	-1.2	-1.6	-1.7	-2.0	-1.5
HbA1C	2.9	3.2	6.4	-1.9	-1.3	-1.9	-2.2	-1.2	-1.8	-1.2	-2.5	-1.6	-2.5	0.4
Hypothyroidism (self reported)	2.9	6.6	31.5	-3.5	3.1	5.6	-1.3	0.6	-1.8	-0.2	1.4	-1.3	-0.2	-3.2
Medication: Levothyroxine sodium	2.8	4.7	16.4	-3.2	2.3	4.0	-1.7	-0.2	-2.5	-1.0	0.6	-1.9	-0.9	-2.1
Illnesses of siblings	2.8	4.0	16.0	2.1	-0.7	-0.6	2.5	-0.7	1.3	2.0	-0.6	3.0	0.6	4.0
Schizophrenia (2014)	2.7	6.0	13.1	-1.9	-2.4	-0.8	-2.8	-1.5	-3.0	-2.2	-3.6	-2.6	-3.5	-0.3
Allergy or Eczema	2.7	7.2	31.6	-0.9	5.4	5.6	-1.2	2.0	-2.7	-0.2	-0.9	-1.1	-1.5	0.8
Hearing aid user	2.7	3.0	11.3	-3.4	1.0	1.9	-2.1	-0.4	-2.5	-0.8	0.4	-1.3	-0.6	-2.0
Average weekly beer plus cider intake	2.7	3.9	7.9	2.3	0.3	-0.6	2.6	1.4	2.4	2.7	0.7	2.8	1.3	2.2
Alcohol drinker status: Previous	2.7	3.0	11.6	1.1	-0.7	-0.6	1.5	0.4	2.4	1.8	3.4	1.5	2.2	-1.3
Schizophrenia vs Biploar Disorder	2.6	3.4	6.6	-1.7	-1.6	-1.0	-2.6	-0.6	-1.6	-2.4	-1.6	-2.0	-2.2	-2.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.6	8.3	26.8	5.2	1.5	-2.5	3.0	4.0	3.7	1.0	0.9	2.5	1.9	2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.6	4.0	14.2	-0.3	1.9	2.3	-0.3	2.0	0.5	-1.0	3.3	-0.7	1.9	-3.8
Pack years adult smoking proportion	2.5	3.9	7.1	-1.5	-1.8	-1.5	-2.1	-2.7	-2.6	-2.1	-2.2	-1.2	-2.4	0.0
Hypothyroidism/myxoedema (self-reported)	2.5	4.8	24.5	-3.0	2.7	5.0	-0.9	0.5	-1.4	0.2	1.4	-1.1	0.0	-2.5
Qualifications: nursing, teaching	2.5	4.0	11.5	1.1	2.3	2.5	0.8	2.6	2.0	1.3	3.4	0.4	2.3	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	12.7	-0.4	0.5	1.8	0.3	1.8	1.8	0.8	3.6	-0.1	2.1	-2.5
Medication: Aspirin	2.4	3.1	8.9	-3.0	-0.6	0.1	-2.1	-1.5	-1.8	-2.0	-0.9	-1.5	-1.1	-2.7
Ever had prostate specific antigen (PSA) test	2.4	2.8	6.7	0.5	2.3	2.4	0.4	2.6	1.2	-0.1	1.9	0.0	2.1	-1.7
Medication: Aspirin	2.3	3.1	8.5	-2.9	-0.1	0.5	-2.1	-1.2	-1.9	-2.2	-0.9	-1.6	-1.2	-2.5
Cholesterol lowering medication	2.3	3.4	6.6	-1.9	-1.7	-0.3	-2.6	-1.4	-1.8	-2.1	-0.8	-2.1	-1.7	-2.5
Schizophrenia (2018)	2.2	4.6	9.4	-1.2	-3.1	-0.4	-2.0	-2.3	-2.7	-1.3	-3.1	-1.7	-2.9	0.3
Respiratory disease	2.2	4.8	18.1	-2.3	3.1	4.3	-1.2	0.2	-3.4	0.2	-1.1	-1.2	-2.1	0.2
Supplements: Zinc	2.2	2.4	7.2	-0.2	1.5	1.2	0.1	2.7	1.4	-0.9	2.3	-0.9	1.3	-2.1
Hayfever, allergic rhinitis or eczema	2.2	4.8	22.3	-0.4	4.7	4.7	-0.5	1.7	-1.7	0.5	0.1	-0.4	-0.5	1.0
Medication: Simvastatin	2.2	3.3	8.8	-3.0	-1.0	0.8	-2.1	-2.3	-2.1	-1.5	-0.5	-2.2	-0.9	-1.8
Prospective memory result	2.2	2.7	7.9	-2.4	1.9	2.8	-1.2	0.9	-0.6	-0.2	1.2	-1.2	0.3	-2.5
Number of children fathered	2.2	2.5	10.0	0.4	2.2	1.1	-0.4	3.2	0.6	-0.1	1.8	-0.8	1.1	-2.3
Alcohol intake frequency.	2.1	4.9	20.5	-1.2	-3.2	-1.8	-1.6	-0.5	0.2	-1.4	3.2	-1.7	0.8	-4.5
Asthma (self-reported)	2.1	4.1	21.4	-2.1	2.8	4.6	-1.0	-0.1	-2.8	1.0	-0.2	-0.6	-1.2	0.2
Ever smoked	2.1	3.7	9.5	0.7	2.2	1.6	-0.2	3.0	0.7	-0.6	2.9	-1.1	1.9	-3.1
Forced vital capacity (FVC)	2.0	7.7	21.7	4.7	2.9	-1.9	2.6	4.5	3.2	0.7	0.3	2.3	1.3	2.5
Allergy	2.0	4.7	22.4	0.8	-4.2	-4.7	0.7	-0.3	2.3	-0.7	0.8	0.3	0.9	-1.8
Hair/balding pattern: Pattern 4	2.0	4.9	17.1	-0.2	4.1	1.8	1.5	3.6	1.5	1.5	2.5	1.2	1.7	-1.7
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	6.7	2.6	-0.0	-0.7	1.4	1.1	2.0	1.4	2.0	2.0	1.8	1.2
Financial situation satisfaction	2.0	2.5	10.2	0.1	-3.2	-2.4	0.2	-2.2	-0.4	0.7	-1.6	0.8	-0.9	1.4
Reaction Time	1.9	3.6	8.0	1.3	-0.3	-1.0	2.8	1.4	2.7	2.2	1.2	1.7	2.1	2.5
Cardiovascular Disease	1.9	6.2	22.8	-2.3	-2.9	-0.5	-3.0	-0.9	-1.6	-2.2	0.9	-3.6	-0.4	-4.8
Leg fat percentage (right)	1.9	6.9	19.3	-0.2	-4.4	-4.3	-2.4	-3.3	-1.9	-1.9	-2.3	-1.8	-2.3	-0.7
Shortness of breath walking on level ground	1.9	2.3	7.8	-0.1	-2.8	-1.9	1.1	-1.8	0.9	1.6	0.1	1.4	0.8	1.7
Medication: Atorvastatin	1.9	2.3	6.5	-0.5	-2.5	-1.1	-1.9	-0.6	-0.8	-1.6	-0.0	-2.0	-1.2	-2.4
Severe depression (siblings)	1.8	2.0	5.3	-0.4	1.4	2.0	-1.5	0.8	-1.1	-1.8	-0.2	-2.3	-0.5	-1.8
Medication: Cholesterol lowering	1.8	2.9	9.3	-3.0	-1.4	0.4	-1.8	-1.6	-1.8	-1.4	-0.2	-2.2	-0.4	-1.9
Headache pain in last month	1.8	3.0	7.6	0.9	-1.9	-2.8	0.7	0.5	2.0	-1.0	2.5	0.1	2.3	-1.9
Medication for cholesterol, blood pressure or diabetes	1.8	2.9	9.4	2.0	-0.7	-1.0	2.0	-1.0	1.3	1.7	-1.0	2.5	0.0	3.1
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	17.1	2.0	3.2	0.8	1.2	4.1	1.4	0.7	1.2	0.8	1.9	0.4
Leg fat percentage (left)	1.8	6.4	18.8	-0.3	-4.3	-4.0	-2.5	-3.0	-1.7	-1.7	-2.2	-1.8	-2.3	-0.7
Heart disease (siblings)	1.8	2.2	10.4	-1.5	-0.5	1.4	-1.6	0.3	-1.0	-0.7	1.3	-1.9	0.2	-3.2
Bipolar Disorder (2011)	1.7	1.7	5.4	-2.2	0.0	-0.2	-1.9	-1.0	-1.7	-0.4	-2.3	0.0	0.0	0.0
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	8.4	-0.3	0.9	1.6	-1.2	0.3	-0.6	-1.6	1.4	-1.7	0.3	-2.9
Past tobacco smoking	1.7	3.0	13.1	-2.0	-2.2	-0.1	-0.4	-3.6	-1.4	0.5	-1.9	0.6	-1.4	1.8
Forced expiratory volume in 1-second (FEV1)	1.7	5.7	20.9	4.6	0.6	-3.1	2.2	2.6	2.7	0.6	-0.0	2.2	1.0	2.4
Asthma	1.7	3.3	19.3	-1.7	2.4	4.4	-0.6	-0.4	-2.5	1.2	-0.1	-0.3	-0.8	0.3
Illnesses of father: Heart disease	1.7	2.4	9.5	-3.1	-0.5	0.4	-1.7	-1.4	-2.5	-1.1	-0.1	-1.3	-1.5	-0.9
Illnesses of father: None of the above (group 1)	1.7	2.1	6.0	2.4	-0.5	-1.3	1.4	-0.5	1.3	1.0	-1.1	1.7	0.4	2.5
Guilty feelings	1.7	2.6	10.6	1.1	2.2	1.2	-0.3	3.3	0.7	-0.4	1.8	-1.6	1.1	-1.8
Age started oral contraceptive pill	1.7	2.2	13.1	-3.6	0.2	0.7	-1.5	-0.9	-1.4	-0.4	-0.4	-1.0	-1.5	-1.2
Coronary Artery Disease (CAD)	1.6	1.9	4.2	-2.0	-1.5	-1.2	-1.2	-1.7	-1.6	-1.3	-2.1	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2018)	1.6	3.1	7.8	-1.9	-2.5	-1.6	-0.8	-1.5	-1.4	-1.5	-2.8	-1.1	-2.3	0.1
Diabetes (self-reported)	1.6	2.4	4.5	-2.1	-1.2	0.8	-1.5	-1.6	-1.9	-1.7	-1.6	-1.5	-1.7	-1.2
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.5	7.7	-0.6	-2.5	-0.7	-1.7	-1.3	-0.7	-2.2	0.6	-1.7	0.1	-2.8
Mouth/teeth dental problems: Dentures	1.6	2.8	7.7	-1.1	-2.0	-1.3	-1.2	-2.8	-1.8	-1.2	-2.2	-0.5	-1.9	-0.7
Loud music exposure frequency	1.6	1.8	6.8	1.7	-1.7	-1.3	0.6	-0.1	0.6	0.5	-1.9	0.2	-0.8	2.6
Had major operations	1.6	1.9	3.3	1.2	1.6	0.5	1.8	1.4	1.6	1.6	0.8	1.8	1.2	1.1
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	9.4	1.1	0.8	-0.9	0.9	2.4	1.7	0.2	3.1	1.2	1.8	-1.4
BMI	1.5	8.6	30.0	2.8	-5.5	-5.0	1.4	-3.8	0.9	2.1	-0.4	2.5	1.5	1.5
Lung FVC	1.5	7.5	24.8	4.1	0.1	-4.2	2.2	5.0	3.1	-0.0	0.1	1.4	-0.5	2.4
High blood pressure	1.5	4.2	19.9	-1.3	-1.2	-0.4	-2.4	0.8	-0.9	-2.3	1.2	-3.1	-0.3	-4.5
Medication: Atenolol	1.5	1.8	6.0	-1.9	1.5	2.4	-1.1	-0.2	-1.4	-0.3	1.0	-1.0	0.2	-1.8
Lung cancer (father)	1.5	1.7	6.7	1.6	-2.0	-2.6	0.7	-1.4	1.1	-0.2	-0.6	1.0	-0.3	0.9
High blood pressure (siblings)	1.5	2.1	6.6	-0.3	1.3	0.4	-0.8	1.7	0.6	-1.6	1.5	-2.2	0.9	-2.6
Family relationship satisfaction	1.5	1.8	5.3	1.5	1.5	0.6	0.7	2.3	1.9	0.9	1.5	0.7	1.6	0.4
Medication for cholesterol	1.5	2.3	7.2	1.1	1.1	-0.2	2.0	0.4	1.3	2.1	0.3	2.1	0.9	2.7
Back pain experienced in last month	1.5	2.2	4.7	-1.2	-1.4	-1.3	-1.4	-0.8	-1.6	-2.2	-1.8	-1.9	-1.5	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	7.6	2.7	-0.8	-2.5	1.8	1.8	2.8	0.9	1.0	1.3	0.9	1.8
Vascular/heart problems diagnosed by doctor	1.5	4.1	18.1	2.0	1.1	0.7	2.3	-0.1	1.4	2.2	-0.8	2.9	0.4	4.3
Bipolar Disorder or Schizophrenia	1.4	3.3	5.5	-1.9	-2.3	0.6	-2.2	-1.6	-2.3	-1.1	-1.9	-2.3	-2.0	-0.6
Depression (Nagel 2018)	1.4	2.1	8.4	-1.6	-0.5	1.1	-0.7	0.2	0.2	-0.2	2.4	-1.4	1.4	-2.9
Heel T-Score	1.4	10.8	44.0	-2.8	1.3	6.6	-1.3	0.1	-0.0	0.4	5.3	-1.2	3.1	-5.0
Lung FEV1/FVC ratio	1.4	7.2	20.2	3.3	-4.5	-4.0	1.6	-1.5	2.8	1.7	2.1	2.2	2.7	0.1
Chronotype (morning person)	1.4	3.2	11.8	0.2	3.4	1.8	1.1	2.4	0.2	0.5	2.7	0.1	2.2	-1.2
Impedance of leg (right)	1.4	6.5	12.7	-2.1	3.0	2.1	-2.6	0.8	-2.3	-3.4	-2.3	-3.3	-3.6	-1.0
Qualifications: CSEs or equivalent	1.4	1.8	6.5	-0.7	-1.9	-2.6	-1.0	-0.8	-0.5	-1.1	-1.6	-0.8	-1.3	1.0
Serious illness, injury or assault to yourself	1.4	1.7	4.5	-1.9	-1.5	1.8	-0.8	-2.1	-1.3	-0.6	-1.3	-0.3	-0.8	0.7
Had other major operations	1.4	1.7	6.1	-2.0	1.1	1.8	-1.1	0.5	-0.8	-0.0	1.2	-0.9	0.5	-2.5
Medication: Blood pressure	1.4	2.4	7.9	-1.3	1.4	1.2	-1.4	2.0	-0.5	-0.9	1.7	-1.8	0.5	-2.8
Medication: Allopurinol	1.4	1.8	5.2	1.4	0.5	-1.6	1.0	2.0	2.3	0.1	1.8	0.3	1.0	-0.8
Hypertension (Self-reported)	1.4	3.8	18.2	-1.2	-1.2	-0.2	-2.1	0.8	-0.9	-2.3	1.1	-3.0	-0.2	-4.3
Leg fat-free mass (right)	1.4	7.6	16.1	3.6	-0.7	-2.4	3.2	0.4	3.0	2.9	1.7	4.0	3.9	1.6
Leg predicted mass (right)	1.4	7.6	16.5	3.6	-0.6	-2.4	3.2	0.4	3.0	2.9	1.7	4.1	3.9	1.5
Illnesses of father: High blood pressure	1.4	1.7	6.2	0.9	1.6	0.7	0.9	2.5	1.5	-0.3	1.8	0.0	1.3	-0.8
Pack years of smoking	1.4	2.0	4.6	-0.8	-1.3	-1.3	-1.3	-2.2	-1.8	-1.5	-1.6	-0.6	-1.8	0.1
Depressed Affect (Nagel 2018)	1.3	2.8	13.7	-1.3	-1.1	0.5	-0.4	-0.5	0.6	-0.7	2.7	-1.1	2.0	-3.7
Alzheimer’s Disease (in mother)	1.3	1.6	5.3	-1.3	-1.5	-1.0	-1.4	0.5	-0.6	-0.7	-1.3	-2.3	-1.3	-0.5
Lupus	1.3	1.9	9.9	0.1	3.1	2.6	0.5	1.6	0.2	0.6	0.5	0.4	0.8	0.4
Leg fat-free mass (left)	1.3	6.9	14.4	3.6	-0.9	-2.9	3.1	0.1	2.6	2.6	1.2	3.8	3.6	1.6
Body mass index (BMI)	1.3	5.6	25.5	1.1	-5.0	-5.0	-0.5	-3.0	-0.2	0.3	-1.0	0.4	-0.2	0.1
Impedance of leg (left)	1.3	6.4	12.2	-2.2	3.0	2.6	-2.7	0.9	-1.9	-3.1	-2.1	-3.3	-3.5	-0.9
Leg predicted mass (left)	1.3	6.8	14.2	3.5	-0.9	-3.0	3.0	0.2	2.6	2.5	1.2	3.8	3.5	1.5
Number of incorrect matches in round	1.3	2.1	10.0	-0.6	-0.9	-3.2	-1.0	0.5	-0.7	-1.1	-1.7	-1.0	-2.3	0.2
Illnesses of mother	1.3	1.6	6.7	1.2	0.2	-0.2	1.0	-0.1	1.4	1.5	-0.2	1.8	0.6	2.6
Mean time to correctly identify matches	1.3	2.5	5.4	0.9	-0.4	-1.2	2.3	1.2	2.3	1.6	1.3	1.1	2.1	1.8
Overall health rating	1.3	2.7	12.0	-0.5	-3.5	-1.7	-1.7	-1.5	-1.0	-1.6	-1.0	-1.5	-1.3	-0.9
Diabetes diagnosed by doctor	1.3	2.1	3.6	-1.6	-1.3	0.3	-1.5	-1.6	-1.9	-1.8	-1.5	-1.4	-1.4	-1.0
Osteoarthritis (self-reported)	1.3	1.7	5.0	-0.1	-0.5	-2.0	-0.7	-0.5	-1.4	-1.1	-2.2	-0.6	-2.2	0.8
Ever taken oral contraceptive pill	1.3	1.4	3.5	0.4	0.2	0.7	1.8	0.6	1.0	1.9	0.7	1.7	1.0	1.7
Pain experienced in last month	1.3	2.1	11.1	-0.8	2.8	3.3	0.3	-0.1	-0.4	1.5	0.4	0.8	0.6	0.4
Supplements: Calcium	1.3	1.4	5.5	0.5	1.6	1.2	-0.2	2.4	0.9	-0.8	1.4	-0.5	0.7	-1.1
Fasting Glucose	1.2	1.4	6.9	1.1	0.5	-0.6	-0.3	2.6	1.1	-1.5	-0.0	-1.2	-0.3	-1.4
Ulcerative Colitis	1.2	1.8	3.9	-0.3	0.5	-0.0	-1.4	1.4	-1.1	-1.8	-1.9	-2.0	-1.8	-0.4
Number of treatments/medications taken	1.2	2.1	6.9	-1.8	-0.3	-0.4	-1.6	1.1	-0.9	-1.6	0.3	-2.3	-0.6	-2.6
Frequency of depressed mood in last 2 weeks	1.2	1.6	7.9	-1.4	0.3	1.0	-1.0	0.2	-0.0	-1.0	1.6	-1.5	0.8	-2.8
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	4.7	-1.9	-0.9	1.5	0.6	-2.2	-0.2	1.1	-0.0	0.8	0.2	0.1
Heart attack	1.2	1.6	5.7	-2.2	-0.9	-0.4	-1.0	-2.4	-1.7	-0.2	-1.1	-0.4	-0.6	-0.3
Pulse wave Arterial Stiffness index	1.2	1.4	5.1	0.6	1.6	2.3	-0.8	1.4	0.2	-1.0	-0.0	-0.8	0.4	-1.7
Pulse wave peak to peak time	1.2	1.4	4.6	-0.3	-1.3	-2.1	1.1	-1.3	0.0	1.1	0.1	1.1	-0.1	2.0
Myopia	1.2	1.8	4.8	0.5	-1.5	-2.1	2.2	0.2	1.6	0.4	-0.3	1.2	0.1	1.9
Age at First Birth	1.1	1.6	7.4	0.7	1.6	0.9	1.3	0.5	0.5	0.9	-0.4	1.8	0.1	2.7
Triglycerides	1.1	1.7	6.5	-0.0	-0.3	-0.1	-1.2	2.6	0.6	-1.5	0.4	-2.5	0.1	-1.4
Arm fat percentage (right)	1.1	4.2	17.0	1.2	-4.1	-4.1	-1.0	-2.7	-0.7	-0.4	-1.1	-0.5	-0.9	-0.0
Hair/balding pattern: Pattern 3	1.1	1.6	6.5	-0.4	-1.0	-2.5	-0.1	0.4	-0.6	-1.0	-1.5	-1.3	-1.4	1.4
Standing height	1.1	10.8	43.2	3.3	6.6	1.4	3.1	4.9	2.7	0.9	1.1	2.6	3.2	1.4
Gout (self-reported)	1.1	1.5	5.4	1.2	-0.3	-1.9	1.4	1.5	2.3	0.4	1.2	0.3	0.8	0.2
Heart disease (mother)	1.1	1.3	3.5	-1.9	1.2	0.9	-1.3	0.6	-1.2	-1.1	0.2	-1.5	-0.4	-1.3
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.9	0.4	-1.0	0.2	0.5	-1.7	1.1	1.4	1.6	0.8	1.7	-0.8
Whole body fat-free mass	1.1	6.2	13.0	3.4	0.1	-3.0	2.9	1.3	2.7	1.9	1.2	3.6	3.4	1.1
Miserableness	1.1	1.9	6.9	-0.8	0.2	0.5	1.0	0.4	1.1	-0.5	2.6	-0.3	2.2	-2.4
Heart attack/myocardial infarction (self-reported)	1.1	1.5	4.9	-2.2	-0.8	-0.6	-1.0	-2.2	-1.7	-0.1	-1.0	-0.3	-0.7	-0.3
Ovarian Cancer	1.0	1.3	3.9	-0.7	0.2	1.1	0.5	-0.2	0.2	2.0	2.0	0.8	1.7	-1.0
Type 2 Diabetes (T2D) (2012)	1.0	1.2	4.2	0.8	-0.4	-0.5	2.1	0.0	1.6	0.5	0.1	1.1	0.5	1.9
Height	1.0	19.4	91.3	4.8	9.6	0.9	3.6	6.5	3.4	0.7	1.5	4.0	3.4	1.6
Medication for hormone replacement therapy	1.0	1.1	3.6	-0.3	0.9	1.6	-0.4	0.5	-0.8	-1.9	-1.0	-1.3	-1.1	0.4
Medication: Co-codamol	1.0	1.2	3.2	0.9	0.6	0.7	1.0	0.6	1.1	1.8	1.4	1.1	1.6	-0.3
Current tobacco smoking	1.0	1.6	4.8	-1.5	-1.1	0.5	-1.4	-0.1	-1.0	-1.4	0.0	-2.2	-0.6	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	8.0	-1.0	-0.0	2.8	-0.2	0.7	0.3	-0.3	2.6	-1.3	1.8	-1.9
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	4.9	0.8	0.1	-1.2	-0.6	2.2	0.5	-1.5	0.2	-1.4	-0.5	-0.4
Alcohol usually taken with meals	1.0	1.6	8.3	-2.0	2.0	2.9	-0.6	-0.2	-0.8	-0.0	0.2	-0.3	-0.1	-0.4
Hearing difficulty/problems with background noise	1.0	1.6	4.9	-0.7	-0.2	-0.7	-0.2	2.1	1.1	-1.2	2.2	-1.5	0.6	-1.4
Had menopause	1.0	1.3	3.8	1.0	-2.0	-1.8	0.1	-1.2	0.6	-0.4	-1.5	-0.3	-1.1	0.7
Financial difficulties in last 2 years	1.0	1.4	8.7	-0.2	-3.0	-2.1	0.0	-1.1	0.1	-0.3	-0.3	0.3	-0.0	0.7
Trunk fat-free mass	1.0	5.5	10.9	3.1	0.9	-3.1	2.7	2.0	2.5	1.1	0.9	3.3	2.9	0.8
Depression (self-reported)	1.0	1.2	4.0	-1.6	-1.5	-0.3	-0.7	-0.5	0.1	0.4	1.5	-0.7	0.6	-2.0
Arm fat mass (right)	1.0	4.0	22.4	1.9	-3.6	-4.7	-0.0	-2.0	0.2	0.1	-0.7	0.6	0.1	0.2
Exposure to tobacco smoke at home	1.0	1.2	3.0	0.5	0.2	-0.2	0.4	0.2	1.7	1.7	1.7	1.2	1.5	-0.1
Birth weight of first child	1.0	1.9	8.7	-2.1	2.3	3.0	0.1	-0.7	-0.6	0.6	0.2	0.6	0.6	0.6
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.2	-1.9	0.7	2.0	-0.8	-0.5	-1.6	0.5	-0.4	-1.2	-0.5	0.0
Body fat percentage	1.0	3.9	13.8	0.6	-3.7	-3.5	-1.4	-2.9	-0.9	-0.7	-1.7	-0.8	-1.3	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.5	-0.7	1.0	-0.7	1.1	0.1	0.2	1.5	-0.8	1.4	-0.7	2.1
Leg fat mass (right)	1.0	3.9	20.1	1.3	-3.8	-4.5	-0.6	-2.2	-0.2	-0.3	-1.2	0.1	-0.3	0.0
Pulse rate, automated reading	1.0	3.3	10.5	-0.3	-3.0	-0.6	-2.3	-1.2	-1.0	-1.4	1.4	-2.0	0.5	-3.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	4.5	0.2	-2.1	-1.8	0.5	-2.1	-0.2	-0.0	-0.2	0.7	0.3	-0.4
Long-standing illness, disability or infirmity	1.0	1.5	8.0	-0.9	-0.3	1.6	-0.9	-0.6	-0.8	-0.7	1.5	-0.7	0.1	-2.8
Ever had bowel cancer screening	1.0	1.1	4.7	1.1	1.4	-0.2	0.8	2.2	0.7	-1.0	0.5	-0.1	1.0	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	8.3	0.4	1.5	0.6	0.1	2.9	0.6	0.5	0.2	-0.6	0.6	-0.2
Commuting to job workplace: Walk	1.0	1.1	3.4	-0.9	0.3	0.9	-1.0	-0.4	-1.8	-1.2	-1.4	-1.1	-1.1	0.1
Breast cancer (self-reported)	1.0	1.1	3.2	-0.7	-0.4	-0.9	-1.1	-1.4	-1.8	-1.1	-1.3	-0.9	-1.0	-0.2
Whole body water mass	1.0	5.9	12.4	3.3	0.0	-3.1	2.8	1.1	2.5	1.8	1.0	3.5	3.2	1.1
Tinnitus: Yes, now most or all of the time	1.0	1.1	4.0	0.1	0.0	0.9	-0.0	-1.4	0.5	1.3	1.4	1.1	0.8	-2.0
Medication: Lisinopril	1.0	1.3	4.6	0.3	1.3	1.5	-0.5	1.1	0.1	-1.1	1.3	-0.9	0.6	-2.1
Basal metabolic rate	1.0	5.3	11.2	3.3	-0.5	-3.3	2.5	0.7	2.4	1.6	0.9	3.3	3.0	1.0
Number of operations (self-reported)	1.0	1.5	6.2	-1.2	1.0	1.8	-0.7	0.9	-0.6	-0.6	1.1	-0.9	0.3	-2.5
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.0	-0.8	-1.4	-1.0	-0.9	-1.3	-0.9	-1.0	-1.7	-0.7	-1.4	-0.1
Primary Biliary Cirrhosis	0.9	1.2	8.6	0.1	-2.9	-1.6	-0.3	-1.0	0.6	-0.1	0.5	-0.4	0.2	-0.4
Smoking Status	0.9	2.1	6.9	0.5	-0.6	-0.7	-1.0	2.1	-0.3	-2.1	-0.1	-2.6	-0.4	-2.3
Hair/balding pattern: Pattern 2	0.9	1.2	3.6	-0.8	1.2	1.9	-1.6	0.1	-0.8	-0.9	0.4	-1.2	0.2	-1.3
Pain all over the body in last month	0.9	1.0	5.0	-0.8	-1.3	-0.3	-0.9	0.6	0.2	-0.0	0.7	-1.1	-0.3	-2.2
Father’s age at death	0.9	1.2	3.7	1.1	0.7	-1.7	0.1	1.2	-0.1	-1.9	-0.4	-0.5	-0.6	1.5
Pulse rate	0.9	1.4	4.6	0.2	-2.1	0.0	-1.2	-0.6	-0.4	-1.2	1.0	-1.3	0.8	-2.1
Trunk predicted mass	0.9	5.2	10.2	3.1	0.9	-3.1	2.6	2.0	2.4	1.1	0.9	3.2	2.8	0.8
Emphysema/chronic bronchitis	0.9	1.0	2.4	-1.6	0.5	1.0	-0.9	-0.2	-1.5	-0.5	-0.3	-1.3	-0.3	-1.4
Medication for pain relief, constipation, heartburn	0.9	1.5	5.8	2.4	1.9	1.3	0.2	1.2	0.6	1.1	0.4	0.6	0.1	1.4
Smoking status: Previous	0.9	1.4	6.6	1.9	1.1	-0.9	-0.0	2.6	0.8	-1.0	0.1	-0.8	0.1	-0.8
Arm fat percentage (left)	0.9	3.7	17.8	1.0	-4.2	-3.5	-0.8	-2.7	-0.6	-0.1	-0.7	-0.4	-0.5	-0.2
Arm fat mass (left)	0.9	3.6	18.9	1.6	-3.6	-4.3	-0.2	-2.1	-0.0	0.0	-0.6	0.4	0.1	-0.1
Leg fat mass (left)	0.9	3.7	19.2	1.4	-3.7	-4.4	-0.5	-2.0	0.1	-0.1	-1.0	0.2	-0.2	0.1
Alzheimer’s Disease (in father)	0.8	0.8	2.0	-0.4	0.7	-0.2	0.7	1.2	1.0	1.4	1.2	0.0	1.3	-0.6
Waist Hip Ratio (WHR)	0.8	3.6	12.8	0.1	1.1	-0.1	-1.2	3.0	-0.1	-3.2	0.6	-3.6	-0.8	-2.0
Neuroticism	0.8	1.9	8.3	-0.1	1.3	0.5	0.2	1.1	0.4	-1.4	2.0	-1.2	1.4	-2.9
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	3.1	-0.5	1.1	1.7	-0.4	1.1	-0.1	0.0	1.5	-0.8	0.6	-1.7
Ever had hysterectomy (womb removed)	0.8	0.9	3.1	-0.5	0.5	1.2	-0.7	1.5	-0.0	-0.8	1.0	-0.8	-0.3	-1.8
Medication: Metformin	0.8	1.1	3.3	-1.8	0.3	0.9	-0.9	-0.2	-0.9	-1.5	-0.3	-1.4	-0.8	-1.3
Diabetes (father)	0.8	1.0	3.0	-1.7	-0.6	-0.7	-1.0	0.7	-1.1	-0.4	-0.4	-1.1	-1.7	-0.1
Diabetes (mother)	0.8	1.0	3.3	1.5	-1.1	-1.8	1.0	-1.0	0.2	-0.7	-0.3	1.2	-0.2	0.2
Townsend deprivation index at recruitment	0.8	1.1	2.3	1.3	1.1	0.7	-0.3	1.4	0.4	-1.3	1.3	-0.5	0.9	-1.5
Average weekly fortified wine intake	0.8	0.9	3.0	-1.2	1.5	1.7	0.4	0.5	-0.0	0.6	1.1	0.7	0.5	-1.0
Fed-up feelings	0.8	1.5	5.6	-0.4	-1.4	-1.2	0.3	-0.5	0.9	-0.9	1.6	-0.3	1.6	-2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	5.0	-1.1	-0.6	0.1	-1.3	0.4	-0.4	-1.1	0.4	-2.2	-0.0	-1.5
Supplements: Glucosamine	0.8	1.1	3.7	1.4	0.8	-0.7	1.3	1.3	0.5	-0.1	-0.9	0.9	-0.5	1.9
High blood pressure (mother)	0.8	1.1	8.1	-0.6	0.0	-0.3	-0.4	0.0	0.1	-0.8	1.5	-0.2	0.6	-2.9
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	7.9	-0.1	-0.3	2.8	-0.4	0.3	-0.2	-0.6	2.3	-1.3	1.4	-1.6
Falls in the last year	0.8	1.1	5.9	0.1	-2.4	-1.0	-0.7	-1.6	0.1	-0.8	0.3	-1.0	-0.3	-0.3
Breastfed as a baby	0.8	1.0	3.5	-0.8	1.5	1.9	0.6	0.9	0.6	0.7	0.9	0.2	1.4	0.0
Blood clot in the leg (DVT)	0.8	1.0	2.0	0.6	-1.1	-1.4	-1.1	-0.9	-0.8	-0.7	-1.1	-1.1	-0.7	1.4
Arm fat-free mass (right)	0.8	4.3	9.3	2.7	-0.1	-2.4	2.5	1.1	2.4	1.5	1.0	2.9	3.0	0.7
Wheeze or whistling in the chest in last year	0.8	1.5	4.6	-0.7	0.4	2.1	-0.5	0.0	-0.8	-0.1	2.1	-0.6	1.0	-2.1
Arm predicted mass (right)	0.8	3.9	9.2	2.5	-0.5	-2.5	2.3	0.6	2.2	1.4	0.9	2.8	3.0	0.6
Suffer from ‘nerves’	0.8	1.2	3.1	0.7	1.0	0.2	1.4	1.8	1.8	0.7	1.3	0.8	1.1	-0.2
Mood swings	0.8	1.4	6.7	-0.2	-0.8	-0.3	-0.7	0.2	0.3	-0.6	2.1	-1.3	1.2	-2.6
Wears glasses or contact lenses	0.8	1.0	3.6	0.7	1.9	0.2	1.6	1.3	1.0	0.3	-0.3	0.7	0.3	0.7
Medication: Blood pressure	0.8	1.6	10.9	-0.4	-0.8	0.0	-1.1	-0.8	-0.6	-0.9	1.1	-0.9	0.6	-3.3
Risk taking	0.8	1.2	5.9	1.2	2.4	1.4	0.3	1.4	0.2	0.3	1.0	0.4	1.0	-0.0
Diastolic blood pressure, automated reading	0.8	2.6	17.9	-0.0	-1.6	-0.4	-1.0	0.0	0.3	-0.6	1.9	-0.9	1.5	-4.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.8	0.5	-1.0	-1.7	-0.9	-1.1	-0.7	-0.5	-0.9	-0.7	-0.5	1.6
Impedance of whole body	0.8	4.1	14.4	-1.4	3.4	3.8	-1.5	0.9	-1.2	-1.7	-0.9	-2.3	-2.0	-0.5
Arm predicted mass (left)	0.8	4.0	15.7	2.6	-1.1	-4.0	1.8	0.3	1.9	1.0	0.1	2.6	2.1	1.1
Body Mass Index (BMI) (2010)	0.7	1.0	3.2	-0.3	-1.5	-1.8	0.6	-1.4	0.3	0.5	-1.0	0.7	0.2	1.0
Blood Eosinophil Count	0.7	5.2	15.0	-0.7	3.5	3.7	0.5	-0.4	-2.7	1.1	-2.1	0.9	-1.3	3.9
Systolic blood pressure, automated reading	0.7	2.1	4.8	-1.1	-1.6	-1.2	-2.0	-0.2	-1.1	-1.4	-1.0	-1.6	-1.6	-2.2
Taking other prescription medications	0.7	1.0	3.5	-0.9	1.4	1.2	-0.0	1.4	-0.0	0.2	1.0	-0.5	0.4	-1.9
Age when periods started (menarche)	0.7	1.7	8.9	0.1	3.0	-0.7	-0.6	-0.0	-1.4	-1.1	-1.7	-0.2	-1.6	0.2
Stomach or abdominal pain in last month	0.7	0.9	3.1	-0.5	-1.8	0.1	-0.8	-1.1	-0.4	-0.5	1.0	-0.8	0.9	-1.4
Weight	0.7	3.4	16.2	2.7	-2.0	-4.0	1.0	-0.8	1.1	0.9	-0.3	1.8	1.4	0.8
Time employed in main current job	0.7	0.9	3.7	0.0	-0.3	0.2	-0.0	-1.2	-0.1	0.8	-1.5	0.7	-0.8	1.9
Alcohol intake versus 10 years previously	0.7	1.0	2.7	-0.6	-0.2	-1.1	-1.4	0.8	-0.8	-1.0	-0.1	-1.2	-1.0	-1.6
Number of live births	0.7	1.0	4.8	-0.7	-0.9	-0.3	-0.3	1.4	0.5	0.3	1.4	-0.9	0.1	-2.2
Impedance of arm (left)	0.7	3.1	16.2	-0.5	3.5	4.0	-0.5	1.1	-0.7	-0.6	-0.0	-1.3	-1.0	-0.1
Health satisfaction	0.7	0.9	5.3	-0.8	-2.3	-0.6	-1.0	-1.1	-0.4	0.2	-1.0	-0.5	-0.7	-0.0
Neck or shoulder pain in last month	0.7	1.0	3.7	1.0	-1.9	-1.5	-0.4	-0.3	-0.4	-1.5	0.2	-0.9	-0.2	-0.6
Whole body fat mass	0.7	3.0	15.3	1.9	-2.9	-3.9	-0.5	-1.9	-0.1	-0.3	-1.2	0.2	-0.2	0.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	4.1	0.9	2.0	-0.1	0.9	1.3	0.4	0.8	-0.3	0.4	0.4	1.0
Loneliness, isolation	0.7	1.0	3.9	-1.1	-1.0	0.4	-1.1	-0.4	0.1	-0.1	1.4	-0.9	1.0	-2.0
Smoking status: Current	0.7	1.2	3.5	-1.2	-0.6	0.6	-1.0	0.3	-0.7	-1.3	0.5	-1.9	-0.1	-1.9
Average weekly champagne plus white wine intake	0.7	1.0	4.8	-1.2	1.5	2.2	-0.1	-0.7	-0.5	0.4	-0.3	0.1	0.7	0.7
Medication: Paracetamol	0.7	1.0	5.4	-0.2	-2.3	-1.1	-0.6	-0.1	-0.3	-0.5	0.2	-1.1	-0.0	-1.7
Arm fat-free mass (left)	0.7	3.5	13.8	2.3	-0.7	-3.7	1.6	0.4	1.8	0.9	0.4	2.5	2.2	0.5
Tanning	0.6	7.9	18.3	2.9	2.1	0.3	3.5	2.4	4.3	3.0	1.9	3.5	2.9	2.1
Hand grip strength (left)	0.6	1.6	5.0	1.9	0.1	-0.7	1.2	1.3	0.7	1.1	-1.2	1.4	-0.1	2.2
Trunk fat percentage	0.6	2.3	7.2	1.0	-2.7	-2.6	-1.0	-2.5	-0.4	-0.1	-1.4	-0.4	-0.7	0.0
Hand grip strength (right)	0.6	1.7	7.3	1.1	-0.3	-1.6	0.2	0.8	-0.2	-0.4	-2.2	-0.2	-1.2	2.7
Multivitamins +/- minerals	0.6	0.8	2.1	-1.3	0.4	1.2	0.4	-0.4	0.2	0.8	1.5	-0.0	1.3	-0.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.0	-0.8	-0.0	-0.5	-0.9	-0.2	-1.4	-1.0	-0.9	-1.0	-1.1	-0.1
Waist circumference	0.6	2.2	10.9	1.2	-2.8	-3.3	-0.9	-0.8	0.0	-0.8	-0.0	-0.7	0.2	-1.0
Impedance of arm (right)	0.6	2.7	11.8	-0.8	3.4	3.2	-0.9	0.9	-0.9	-0.7	-0.4	-1.3	-1.4	-0.1
Hip circumference	0.6	2.5	9.9	1.6	-2.8	-3.1	0.5	-1.6	0.7	1.0	-0.2	1.5	0.9	0.4
Happiness	0.6	0.7	2.2	-0.5	0.2	0.5	-1.3	-0.5	-0.7	-0.5	0.9	-1.1	-0.2	-1.5
Noisy workplace	0.6	0.8	2.6	0.8	-0.2	0.1	1.0	0.8	1.6	0.7	1.3	0.9	0.8	-0.2
Ever highly irritable/argumentative for 2 days	0.6	0.8	2.3	-0.5	0.3	0.4	-0.6	-0.9	-1.5	-0.6	-1.5	-0.0	-1.3	-0.1
Medication: Amlodipine	0.6	0.9	3.8	-1.0	0.9	0.7	-0.5	0.8	-0.7	-1.0	0.3	-1.0	0.1	-1.9
Birth weight	0.6	1.4	5.6	-0.7	2.4	1.6	0.1	0.5	0.6	1.2	1.5	1.2	1.1	-0.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.8	0.8	1.0	1.0	0.2	1.3	-0.0	1.1	1.0	-0.1	1.1	-0.5
Qualifications: College or University degree	0.6	1.9	6.1	-0.6	2.5	1.9	1.7	1.5	1.1	0.4	0.1	0.8	0.4	2.0
Supplements: Vitamin C	0.6	0.7	4.0	0.3	-0.1	-0.8	1.1	-0.1	0.8	-0.1	-0.3	1.1	-0.3	2.0
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.8	0.0	-1.1	-0.7	-0.8	-0.4	-0.7	-1.3	-1.2	-1.1	-0.9	0.1
Eye problems/disorders: Cataract	0.6	0.6	2.8	-1.1	0.7	1.7	0.5	0.4	0.5	-0.0	0.9	-0.5	1.0	-0.0
Fractured/broken bones in last 5 years	0.6	0.8	2.9	0.8	-1.7	-1.0	0.3	-0.1	0.7	0.7	1.2	0.3	0.8	-1.0
Commuting to job workplace: Cycle	0.6	0.8	3.6	-0.7	1.6	1.9	0.3	0.7	-0.1	-0.0	0.9	-0.3	0.4	0.5
Bipolar Disorder (2018)	0.5	0.9	2.2	-1.5	0.1	1.4	-1.0	0.2	-0.3	-0.0	0.6	-1.5	0.4	-1.2
Neuroticism (Nagel 2018)	0.5	1.2	4.7	-0.0	0.2	0.6	0.3	0.7	0.9	-0.5	2.2	-0.5	1.4	-2.2
Alzheimer’s Disease (including proxy)	0.5	0.8	2.8	-0.7	-0.3	-0.9	-0.5	1.7	0.8	0.6	0.3	-1.4	-0.1	-1.0
Ulcerative Colitis (UC)	0.5	0.9	2.4	-0.5	-0.3	-0.4	-1.1	-0.3	-1.4	-1.0	-1.6	-0.9	-1.4	-0.0
Major Depression (MDD)	0.5	0.6	2.4	-0.9	-0.3	-0.4	-1.0	-0.2	-0.5	-0.9	-0.0	-1.6	-0.5	-1.1
Verbal and Numeric Reasoning (VNR)	0.5	1.1	4.8	-1.1	1.3	1.3	0.1	0.1	-0.6	-0.6	-1.0	-0.8	-0.7	2.2
Neuroticism (2016)	0.5	0.8	4.3	-0.5	-0.5	-0.7	0.7	0.4	0.6	-0.8	0.9	-0.4	0.9	-2.1
Blood White Count	0.5	4.0	14.4	-0.5	-3.8	-3.0	-1.4	-2.7	-1.7	-1.1	-1.2	-1.6	-1.4	-0.9
Average weekly spirits intake	0.5	0.6	2.1	-0.5	-1.0	1.0	-0.8	-1.4	-0.7	-0.2	0.1	-0.7	0.1	-0.8
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.8	1.0	0.6	0.8	-0.0	0.9	0.2	-1.7	0.3	-0.9	-0.1	-0.9
Trunk fat mass	0.5	2.2	10.9	1.8	-2.4	-3.3	-0.2	-1.8	0.2	0.2	-1.0	0.5	0.1	0.3
Qualifications: A levels/AS levels or equivalent	0.5	1.1	5.5	-0.8	1.7	2.3	0.7	0.4	0.2	0.3	0.9	0.3	0.4	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.1	-0.9	0.5	0.9	-0.2	0.2	-0.8	-1.4	-0.6	-0.7	-1.1	-0.2
Medication: Lansoprazole	0.5	0.5	2.5	-1.0	-0.5	-1.2	-0.3	-0.0	0.4	-0.1	-0.4	-0.1	-0.6	-1.6
Tense / ‘highly strung’	0.5	0.9	6.6	2.6	0.4	-0.5	1.1	0.3	0.6	0.4	0.2	0.5	0.5	-0.1
Mouth/teeth dental problems: Loose teeth	0.5	0.7	2.8	1.7	-0.5	-1.3	0.8	-0.1	-0.1	-0.4	-0.2	0.3	-0.8	0.9
Medication: Omeprazole	0.5	0.6	1.9	0.7	-1.2	-1.4	0.0	-0.9	0.3	0.0	-1.2	0.3	-0.3	0.3
Medication: Seretide 50 evohaler	0.5	0.5	1.6	-0.6	0.4	0.4	0.3	-0.9	-0.7	0.3	-1.2	0.5	-0.8	1.2
Chest pain or discomfort	0.5	0.8	3.0	0.2	-1.7	0.2	0.2	-1.0	-0.0	-0.5	1.1	-0.1	0.7	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.3	-0.3	-1.5	-0.4	-0.8	-0.2	-0.4	-0.6	-0.4	-1.4	-0.4	-0.3
Basal cell carcinoma (self-reported)	0.5	0.7	2.4	-0.7	1.5	1.3	0.2	1.4	0.3	-0.3	-0.4	-0.5	0.2	-0.3
Crohns Disease (2012)	0.4	0.6	2.8	-1.7	-0.0	0.6	-0.5	0.4	-0.3	-1.0	0.4	-0.6	-0.2	-1.2
Systolic Blood Pressure	0.4	2.0	6.9	-0.6	-1.7	-0.2	-1.8	0.5	-0.9	-1.4	-0.4	-2.1	-1.1	-2.6
Relative age of first facial hair	0.4	0.8	2.9	1.5	1.3	1.0	-0.4	-0.3	-0.4	-1.7	-0.4	-0.7	-0.6	0.2
Relative age voice broke	0.4	0.6	2.2	1.5	1.0	0.0	0.5	-0.2	-0.4	-1.1	-0.7	0.1	-0.4	0.9
Sitting height	0.4	2.6	8.2	0.4	2.7	0.1	2.0	0.5	1.0	0.9	-0.1	2.9	2.1	1.7
Fluid intelligence score	0.4	0.7	4.6	-0.2	1.3	1.1	0.5	0.1	0.0	-0.1	-0.0	-0.5	0.2	2.1
Neuroticism score	0.4	0.8	2.9	0.1	1.1	0.3	0.4	0.4	0.4	-1.1	1.1	-0.8	1.1	-1.7
Worrier / anxious feelings	0.4	0.7	3.2	1.0	-0.2	-1.2	1.0	0.3	0.7	-1.8	0.0	-0.2	0.0	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.6	-0.5	0.0	-1.3	1.2	0.3	0.6	-0.1	-0.1	0.6	0.7	0.6
Peak expiratory flow (PEF)	0.4	1.0	2.7	1.7	-0.3	-1.5	0.9	0.1	0.5	0.6	-0.7	1.4	-0.4	1.5
Pulse wave reflection index	0.4	0.5	3.2	-0.2	1.2	0.4	-0.2	1.8	0.5	-0.4	-0.1	-0.4	0.0	-0.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	3.0	-1.7	0.4	1.2	-0.5	-0.1	-1.0	-0.7	0.2	-0.8	-0.4	-0.3
Medication: Paracetamol	0.4	0.7	4.7	-0.3	-2.2	-1.2	0.2	-0.0	0.2	0.0	0.4	-0.5	0.4	-1.1
Number of full brothers	0.4	0.5	1.8	0.2	-1.3	-0.3	0.2	0.5	0.3	-0.8	0.7	-1.2	0.2	-1.0
Worry too long after embarrassment	0.4	0.7	1.6	-0.5	1.0	1.3	1.2	-0.2	1.0	0.7	0.7	0.4	1.0	0.2
Age at first live birth	0.4	0.8	4.1	-1.5	0.9	2.0	-0.4	-0.7	-0.7	-0.0	0.2	-0.1	0.1	0.4
Migraine (self-reported)	0.4	0.5	3.5	0.2	0.0	-1.9	0.4	0.4	0.6	-0.6	0.8	0.0	0.7	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.7	0.7	1.3	0.5	-0.3	1.0	0.2	0.5	1.3	-0.3	0.5	-0.4
Comparative height size at age 10	0.4	2.1	6.0	1.1	1.6	-0.0	1.6	2.4	1.9	0.8	1.1	1.1	2.0	-0.6
Knee pain experienced in last month	0.4	0.6	1.7	1.3	-0.2	-1.0	0.9	0.5	0.6	0.6	-0.5	1.0	-0.5	0.9
Average weekly red wine intake	0.4	0.6	2.5	-0.3	-0.3	0.9	0.5	-1.6	-0.7	0.9	-0.4	1.0	-0.1	0.3
Friendships satisfaction	0.4	0.5	1.8	-0.5	-0.8	0.6	0.2	-0.9	0.5	1.4	0.3	0.8	0.5	0.5
Medication: Gliclazide	0.4	0.5	1.8	0.0	0.5	0.6	-0.2	0.9	0.0	0.2	1.2	-0.4	0.8	-1.4
Eye problems/disorders: Glaucoma	0.4	0.5	1.1	-0.2	1.0	-0.0	-1.0	1.1	-0.7	-0.5	0.1	-0.9	-0.6	-0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.6	2.4	0.2	1.1	-0.0	-0.1	1.6	-0.3	-1.1	-0.4	-0.8	-0.7	0.1
Alcohol drinker status: Never	0.4	0.5	2.9	-0.9	0.2	-0.4	-0.4	-0.1	0.2	-0.8	0.4	-0.2	-0.3	-1.7
Irritability	0.4	0.8	2.5	0.6	1.0	0.2	1.1	-0.2	0.6	0.7	-0.2	1.5	0.2	1.6
Intelligence (Savage-Jansen 2018)	0.3	0.9	3.0	-0.5	1.4	1.2	0.5	1.1	-0.0	-0.9	0.4	-1.0	0.2	1.7
Crohns Disease (2017)	0.3	0.7	1.9	-0.6	1.0	1.4	-0.1	0.5	-0.3	-1.2	1.2	-0.5	0.4	-1.0
Mean Putamen Volume	0.3	0.4	1.1	-0.9	0.2	0.2	-0.0	-1.1	-0.2	0.5	1.0	0.0	0.7	-0.0
HDL Cholesterol	0.3	0.6	3.2	0.3	1.8	0.6	0.4	0.8	-0.2	0.5	-0.1	1.0	-0.4	0.4
Rheumatoid Arthritis	0.3	0.4	1.1	-0.6	-0.6	0.5	-0.9	-1.0	-1.0	-0.2	-0.1	-0.2	-0.2	-0.8
Vitamin and mineral supplements	0.3	0.4	1.0	0.9	-0.2	0.6	-0.9	-0.3	-0.7	0.3	-1.0	-0.0	-0.7	-0.1
Length of working week for main job	0.3	0.3	1.6	0.8	0.4	1.3	-0.5	-0.8	-0.4	0.2	-0.1	0.5	0.2	-0.2
Glaucoma (self-reported)	0.3	0.4	1.6	0.1	1.3	0.2	-0.4	1.1	-0.6	0.2	-0.4	-0.3	-0.4	0.3
Exposure to tobacco smoke outside home	0.3	0.4	0.7	-0.2	-0.6	-0.7	-0.9	0.6	0.3	-0.7	0.7	-0.4	-0.1	-0.9
Comparative body size at age 10	0.3	0.8	3.2	-0.0	-1.3	-0.5	-0.2	-1.8	-0.1	-0.6	0.9	0.1	0.8	-1.2
Age at last live birth	0.3	0.4	1.3	-1.1	0.1	1.0	-0.9	-0.5	-1.0	0.1	-0.0	-0.4	-0.1	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	2.1	-1.4	-0.5	-0.2	-0.1	-0.6	-0.8	-0.2	-0.7	-0.1	-0.5	0.5
Mineral and other dietary supplements	0.3	0.4	1.3	-0.4	-0.3	0.7	-1.0	-1.2	-0.4	0.2	0.4	-0.4	0.4	-1.1
Osteoporosis (self-reported)	0.3	0.4	1.8	1.0	-0.3	-1.3	0.9	0.0	-0.1	-0.2	-0.1	0.3	0.0	0.3
Commuting to job workplace: Public transport	0.3	0.3	1.3	-0.2	0.5	0.0	-0.1	0.1	-0.5	-0.3	-1.1	0.0	-0.7	1.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.2	1.1	-0.4	-0.3	0.4	0.8	0.9	0.6	0.3	0.4	0.2	-0.7
Medication: Bendroflumethiazide	0.3	0.5	2.9	0.7	-0.2	0.4	-0.6	0.3	0.1	0.1	0.7	-0.7	0.7	-1.7
Irritable Bowel Disease (IBD)	0.2	0.4	2.0	-0.4	-0.0	-0.1	-0.5	-0.0	-0.9	-1.4	-0.7	-0.6	-0.9	0.0
LDL Cholesterol	0.2	0.3	1.3	-0.1	0.6	0.6	-0.5	1.1	-0.0	-0.1	0.5	-0.9	-0.0	0.7
Sensitivity / hurt feelings	0.2	0.4	1.8	-0.2	0.3	-1.3	-0.3	-0.8	-0.5	-1.1	-0.4	-0.3	-0.2	-0.3
Hearing difficulty/problems: Yes	0.2	0.3	1.8	0.1	-0.1	0.8	0.4	0.2	0.4	0.4	1.3	-0.3	0.5	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.1	0.1	-0.6	-0.2	-0.3	-0.4	-0.2	-1.0	0.4	-0.6	0.1	-0.9
Qualifications: None of the above	0.2	0.5	2.5	0.9	-0.2	-1.0	-0.3	0.5	0.5	0.3	0.3	0.9	-0.2	-1.6
Mouth/teeth dental problems	0.2	0.3	1.5	-0.6	0.8	1.2	0.3	0.4	0.3	0.8	-0.2	-0.3	0.4	0.4
Medication: Ramipril	0.2	0.2	1.2	-1.1	-0.2	0.1	-0.3	-0.7	-0.1	0.0	0.1	0.3	0.1	-0.9
Medication: Ibuprofen	0.2	0.3	1.1	-0.6	0.3	-0.3	0.8	0.7	0.2	0.3	0.2	0.3	1.0	0.4
Leg pain on walking	0.2	0.3	1.2	0.9	0.2	-0.1	0.4	-0.0	0.5	0.6	0.1	0.5	0.3	1.1
Mother’s age at death	0.2	0.2	0.5	0.6	-0.1	-0.4	0.2	0.6	-0.0	-0.6	-0.5	0.3	-0.7	0.6
Worry (Nagel 2018)	0.1	0.3	0.6	0.8	0.2	-0.3	0.5	0.7	0.6	-0.8	0.4	-0.4	0.0	-0.6
Hair Pigment	0.1	3.7	11.3	0.2	-1.3	-0.7	-3.4	0.2	-2.0	-2.3	-0.3	-2.1	-1.8	-3.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.6	0.0	0.4	0.8	0.5	0.2	0.2	-0.2	-0.2	0.3	-0.2	-0.3
Nervous feelings	0.1	0.3	1.4	0.5	0.6	0.5	1.2	0.3	0.2	-0.4	0.4	-0.2	0.4	-0.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.5	0.2	0.2	0.1	0.0	-0.2	0.0	-0.0	0.7	-0.4	0.1	-0.5
Eye problems/disorders: None of the above	0.1	0.2	0.6	0.8	-0.2	-0.2	0.1	0.3	0.1	0.1	-0.4	0.2	-0.4	0.7
Number of full sisters	0.1	0.2	1.5	0.2	-0.2	-0.2	-0.2	0.0	0.0	0.1	-1.2	-0.3	-0.3	0.4
Ever depressed for a whole week	0.1	0.1	0.4	0.6	-0.3	0.1	0.4	-0.4	0.1	0.4	0.6	0.1	0.3	-0.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

RBMS2

Models

Trait associations