Best TWAS P=1.28e-33 · Best GWAS P=1.84e-45 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Hypothalamus | CYLD | 0.38 | 0.13 | enet | 36 | 0.15 | 2.7e-04 | -8.22 | -6.2 | 6.9e-10 | -0.28 | 0.14 | 0.09 | TRUE |
2 | GTEx | Colon Transverse | NKD1 | 0.22 | 0.00 | enet | 42 | 0.05 | 2.5e-03 | -0.51 | -5.8 | 6.2e-09 | -0.17 | 0.21 | 0.11 | TRUE |
3 | GTEx | Esophagus Mucosa | CYLD | 0.13 | 0.06 | enet | 10 | 0.06 | 7.0e-05 | -8.73 | 11.9 | 1.5e-32 | 0.72 | 0.06 | 0.93 | TRUE |
4 | GTEx | Esophagus Mucosa | NOD2 | 0.19 | 0.14 | lasso | 7 | 0.15 | 4.1e-10 | -8.31 | 8.9 | 7.0e-19 | 0.46 | 0.99 | 0.01 | FALSE |
5 | GTEx | Nerve Tibial | CYLD | 0.10 | 0.00 | lasso | 6 | 0.00 | 1.7e-01 | 6.95 | 6.7 | 1.9e-11 | 0.37 | 0.10 | 0.05 | TRUE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | NOD2 | 0.15 | 0.06 | lasso | 4 | 0.02 | 1.9e-02 | -8.29 | 8.6 | 6.7e-18 | 0.46 | 0.54 | 0.24 | TRUE |
7 | GTEx | Testis | NKD1 | 0.24 | 0.13 | lasso | 4 | 0.14 | 8.1e-07 | 6.15 | 7.5 | 4.5e-14 | 0.10 | 0.76 | 0.01 | TRUE |
8 | GTEx | Testis | HEATR3 | 0.47 | 0.37 | enet | 33 | 0.38 | 4.5e-18 | 3.56 | -5.2 | 2.0e-07 | -0.10 | 1.00 | 0.00 | TRUE |
9 | GTEx | Whole Blood | BRD7 | 0.16 | 0.12 | enet | 9 | 0.12 | 4.2e-11 | -6.28 | -6.2 | 5.6e-10 | 0.00 | 1.00 | 0.00 | TRUE |
10 | METSIM | Adipose | ADCY7 | 0.04 | 0.00 | enet | 22 | 0.01 | 1.7e-02 | 1.49 | -6.9 | 4.6e-12 | -0.03 | 0.20 | 0.04 | TRUE |
11 | METSIM | Adipose | BRD7 | 0.06 | 0.05 | lasso | 6 | 0.05 | 1.1e-07 | -6.28 | -6.2 | 6.4e-10 | 0.01 | 1.00 | 0.00 | TRUE |
12 | NTR | Blood | ADCY7 | 0.07 | 0.06 | enet | 17 | 0.07 | 2.0e-20 | -6.30 | -6.1 | 1.3e-09 | 0.01 | 1.00 | 0.00 | FALSE |
13 | YFS | Blood | PAPD5 | 0.03 | 0.01 | enet | 13 | 0.02 | 1.4e-07 | -6.41 | -6.2 | 5.7e-10 | 0.02 | 0.96 | 0.00 | FALSE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CYLD | 0.03 | 0.03 | enet | 7 | 0.02 | 9.3e-04 | -8.56 | 6.0 | 1.7e-09 | 0.29 | 0.26 | 0.04 | TRUE |
15 | The Cancer Genome Atlas | Lung Adenocarcinoma | CYLD | 0.03 | 0.00 | blup | 69 | 0.02 | 3.8e-03 | -8.73 | 11.9 | 1.5e-32 | 0.60 | 0.11 | 0.66 | TRUE |
16 | The Cancer Genome Atlas | Lung Adenocarcinoma | NOD2 | 0.07 | 0.01 | lasso | 4 | 0.02 | 1.1e-03 | 14.15 | 12.1 | 1.3e-33 | 0.78 | 0.00 | 0.91 | TRUE |