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chr1:109,154,974-110,750,277

Best TWAS P=2.25e-11 · Best GWAS P=1.57e-10 conditioned to 0.378

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Brain Caudate basal ganglia	AMIGO1	0.17	0.00	enet	10	0.00	4.4e-01	-4.7	5.2	1.8e-07	0.60	0.08	0.16	FALSE
2	GTEx	Brain Cerebellar Hemisphere	SYPL2	0.28	0.04	lasso	5	0.09	2.7e-03	6.2	6.7	2.2e-11	0.90	0.04	0.93	TRUE
3	GTEx	Brain Cerebellum	SYPL2	0.16	0.02	enet	9	0.03	5.1e-02	6.1	6.2	5.0e-10	0.98	0.04	0.90	FALSE
4	GTEx	Liver	SYPL2	0.34	0.27	lasso	5	0.30	4.6e-09	6.2	5.9	3.8e-09	0.90	0.04	0.96	FALSE
5	GTEx	Muscle Skeletal	CYB561D1	0.07	0.00	lasso	3	0.00	7.2e-01	6.2	-6.1	9.6e-10	-0.88	0.04	0.88	FALSE
6	GTEx	Ovary	SYPL2	0.39	0.44	lasso	5	0.46	8.8e-13	6.2	-6.3	2.4e-10	-0.96	0.04	0.96	FALSE
7	GTEx	Ovary	ATXN7L2	0.18	0.18	enet	17	0.13	5.6e-04	6.2	-6.3	3.8e-10	-0.90	0.04	0.92	FALSE
8	GTEx	Pancreas	SYPL2	0.28	0.23	lasso	5	0.19	2.0e-08	5.0	5.5	4.9e-08	0.82	0.08	0.92	FALSE
9	GTEx	Stomach	SYPL2	0.23	0.18	lasso	8	0.21	2.3e-10	6.2	5.8	5.8e-09	0.91	0.04	0.96	FALSE
10	GTEx	Testis	SYPL2	0.45	0.50	enet	22	0.54	5.0e-28	6.2	-6.3	2.2e-10	-0.93	0.04	0.96	FALSE
11	GTEx	Testis	ATXN7L2	0.28	0.34	lasso	4	0.33	3.7e-15	6.2	-6.2	4.8e-10	-0.90	0.04	0.96	FALSE
12	GTEx	Uterus	SYPL2	0.29	0.13	lasso	7	0.04	5.1e-02	6.2	-5.6	2.2e-08	-0.92	0.03	0.75	FALSE
13	METSIM	Adipose	SYPL2	0.06	0.06	blup	418	0.05	4.3e-08	5.0	5.6	1.7e-08	0.81	0.05	0.95	FALSE
14	NTR	Blood	SORT1	0.05	0.06	lasso	6	0.06	2.1e-17	6.2	6.5	9.8e-11	0.87	0.04	0.96	FALSE
15	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AMIGO1	0.10	0.14	enet	10	0.11	2.8e-09	3.9	5.6	2.7e-08	0.63	1.00	0.00	FALSE
16	The Cancer Genome Atlas	Esophageal Carcinoma	AMIGO1	0.24	0.08	blup	46	0.18	3.0e-06	3.3	5.4	7.0e-08	0.62	0.09	0.31	FALSE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SYPL2	0.03	0.05	lasso	4	0.05	6.6e-06	6.2	6.3	3.9e-10	0.91	0.02	0.98	FALSE
18	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SYPL2	0.04	0.04	blup	45	0.04	3.6e-03	6.4	-5.5	3.9e-08	-0.93	0.01	0.75	FALSE
19	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SYPL2	0.18	0.19	blup	45	0.18	4.7e-09	6.2	6.4	1.2e-10	0.94	0.02	0.98	FALSE
20	The Cancer Genome Atlas	Lung Adenocarcinoma	SYPL2	0.09	0.14	enet	13	0.14	1.3e-16	6.2	5.5	3.0e-08	0.92	0.02	0.98	FALSE
21	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SYPL2	0.05	0.06	blup	45	0.06	4.4e-07	6.2	5.5	4.3e-08	0.91	0.02	0.98	FALSE
22	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	AMIGO1	0.06	0.00	blup	46	0.02	9.5e-03	4.2	5.4	6.6e-08	0.79	0.03	0.29	FALSE
23	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MYBPHL	0.16	0.18	enet	10	0.17	2.3e-11	6.2	6.1	1.1e-09	0.88	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Prostate Adenocarcinoma	SYPL2	0.08	0.08	blup	44	0.10	1.9e-10	6.1	6.1	1.2e-09	0.96	0.02	0.98	FALSE
25	The Cancer Genome Atlas	Stomach Adenocarcinoma	SYPL2	0.05	0.02	blup	45	0.03	2.6e-03	6.2	5.4	5.9e-08	0.90	0.02	0.81	FALSE
26	The Cancer Genome Atlas	Testicular Germ Cell Tumors	AMIGO1	0.14	0.14	blup	46	0.14	1.1e-05	3.7	5.2	1.5e-07	0.65	0.37	0.40	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	ATXN7L2	0.06	0.06	lasso	3	0.05	6.6e-06	6.1	-6.2	4.1e-10	-0.96	0.02	0.98	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	SYPL2	0.07	0.04	blup	45	0.03	4.9e-04	6.1	-5.6	2.6e-08	-0.89	0.02	0.97	FALSE