[Hub]/) : Traits : LDL Cholesterol : →

chr1:24,871,730-26,855,401

Best TWAS P=2.29e-12 · Best GWAS P=1.95e-10 conditioned to 0.295

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	GTEx	Uterus	TMEM50A	0.29	0.11	enet	15	0.04	6.0e-02	-4.5	-7.0	2.3e-12	0.72	0.03	0.70	TRUE
14	GTEx	Esophagus Muscularis	LDLRAP1	0.11	0.01	enet	15	0.02	2.5e-02	3.8	6.2	6.6e-10	-0.44	0.08	0.35	TRUE
5	GTEx	Artery Aorta	TMEM57	0.14	0.15	enet	10	0.14	3.3e-08	-6.2	6.3	2.7e-10	-0.95	0.02	0.98	FALSE
12	GTEx	Colon Transverse	LDLRAP1	0.27	0.14	lasso	4	0.11	5.4e-06	-5.9	6.3	2.8e-10	-0.85	0.04	0.93	FALSE
18	GTEx	Nerve Tibial	TMEM50A	0.10	0.02	lasso	3	0.03	2.6e-03	-6.1	-6.3	3.2e-10	0.85	0.03	0.83	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	RHCE	0.29	0.36	lasso	7	0.35	6.3e-47	-6.1	6.2	5.6e-10	-0.99	0.02	0.98	FALSE
11	GTEx	Cells Transformed fibroblasts	C1orf63	0.09	0.04	lasso	5	0.03	2.5e-03	-6.0	-6.2	5.7e-10	0.98	0.02	0.97	FALSE
7	GTEx	Breast Mammary Tissue	RP11-335G20.7	0.23	0.10	enet	5	0.09	2.4e-05	-6.2	-6.2	6.4e-10	0.98	0.02	0.98	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	TMEM57	0.04	0.04	lasso	2	0.04	8.5e-06	-6.2	6.2	6.4e-10	-0.97	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TMEM50A	0.32	0.37	lasso	8	0.37	6.9e-47	-6.2	6.2	6.8e-10	-0.99	0.03	0.97	FALSE
21	GTEx	Thyroid	TMEM50A	0.19	0.11	lasso	2	0.08	2.0e-06	-6.1	-6.1	1.2e-09	0.95	0.03	0.97	FALSE
16	GTEx	Esophagus Muscularis	TMEM57	0.09	0.08	enet	14	0.07	5.2e-05	-6.2	6.0	1.6e-09	-0.95	0.02	0.98	FALSE
19	GTEx	Skin Sun Exposed Lower leg	TMEM50A	0.13	0.14	enet	6	0.11	2.6e-09	-6.1	-6.0	1.6e-09	0.96	0.03	0.97	FALSE
4	GTEx	Adrenal Gland	TMEM50A	0.31	0.18	enet	16	0.11	7.2e-05	-6.2	-6.0	1.9e-09	0.96	0.02	0.98	FALSE
20	GTEx	Testis	TMEM57	0.25	0.11	enet	17	0.12	7.4e-06	-6.2	6.0	2.0e-09	-0.85	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RHCE	0.29	0.34	lasso	4	0.34	2.0e-42	-5.9	5.9	3.3e-09	-0.94	0.04	0.96	FALSE
23	METSIM	Adipose	RHCE	0.09	0.09	enet	28	0.10	4.5e-15	-6.1	5.9	4.6e-09	-0.95	0.02	0.98	FALSE
10	GTEx	Breast Mammary Tissue (Female)	RP11-335G20.7	0.47	0.19	enet	23	0.10	9.0e-04	-6.3	-5.8	6.6e-09	0.84	0.01	0.98	FALSE
17	GTEx	Lung	TMEM50A	0.14	0.04	enet	15	0.00	1.3e-01	-6.1	-5.8	9.0e-09	0.76	0.03	0.91	FALSE
9	GTEx	Breast Mammary Tissue (Male)	RP11-335G20.7	0.08	-0.01	lasso	2	0.09	3.6e-03	-6.2	-5.6	1.9e-08	0.93	0.02	0.36	FALSE
8	GTEx	Breast Mammary Tissue (Male)	MTFR1L	0.11	0.00	enet	18	-0.01	4.6e-01	1.7	5.3	8.7e-08	-0.55	0.04	0.34	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	LDLRAP1	0.27	0.03	lasso	5	0.02	5.1e-02	3.9	5.3	1.2e-07	-0.36	0.04	0.18	FALSE
3	GTEx	Adipose Subcutaneous	RP11-335G20.7	0.22	0.03	enet	24	0.07	1.3e-06	-6.3	-5.2	1.9e-07	0.73	0.01	0.99	FALSE
6	GTEx	Artery Tibial	TMEM57	0.10	0.03	enet	25	0.04	7.2e-04	-6.0	5.2	2.1e-07	-0.79	0.02	0.97	FALSE
15	GTEx	Esophagus Muscularis	TMEM50A	0.17	0.05	lasso	6	0.08	9.1e-06	-3.5	-5.2	2.4e-07	0.72	0.07	0.82	FALSE