TWAS hub - TMEM57

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1440	0.0460	2.8e-04	0.148	NA	0.141	NA	0.075	1.5e-08	NA	3.3e-08	NA	6.2e-05
2	GTEx	Artery Tibial	0.0951	0.0365	2.7e-03	0.034	NA	0.036	NA	0.035	1.1e-03	NA	7.2e-04	NA	9.5e-04
3	GTEx	Esophagus Muscularis	0.0940	0.0370	3.6e-03	0.082	NA	0.069	NA	-0.005	1.1e-05	NA	5.2e-05	NA	8.6e-01
4	GTEx	Testis	0.2540	0.0660	5.6e-07	0.113	NA	0.117	NA	0.004	1.1e-05	NA	7.4e-06	NA	2.0e-01
5	ROSMAP	Brain Pre-frontal Cortex	0.0417	0.0168	1.6e-03	0.044	0.021	0.036	0.024	0.039	2.4e-06	9.1e-04	1.8e-05	4e-04	8.5e-06
6	TCGA	Breast Invasive Carcinoma	0.0649	0.0432	1.1e-06	0.021	0.021	0.019	NA	0.022	2.9e-05	3.3e-05	5.7e-05	NA	2.3e-05
7	TCGA	Colon Adenocarcinoma	0.0600	0.0490	2.8e-03	0.027	0.020	0.024	NA	0.014	1.1e-02	2.5e-02	1.5e-02	NA	4.7e-02
8	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1630	0.1290	1.1e-04	0.037	0.009	0.042	NA	-0.004	3.2e-03	9.4e-02	1.8e-03	NA	7.4e-01
9	TCGA	Brain Lower Grade Glioma	0.0681	0.0419	1.0e-07	0.043	0.050	0.054	NA	0.054	1.2e-05	2.3e-06	9.8e-07	NA	9.1e-07
10	TCGA	Lung Adenocarcinoma	0.1249	0.0796	2.7e-03	-0.001	-0.002	0.006	NA	0.000	4.9e-01	7.0e-01	5.6e-02	NA	3.8e-01
11	TCGA	Lung Squamous Cell Carcinoma	0.0235	0.0191	5.7e-03	0.005	0.002	0.000	NA	0.000	8.1e-02	2.0e-01	3.4e-01	NA	2.8e-01
12	TCGA	Ovarian Serous Cystadenocarcinoma	0.0440	0.0340	2.4e-03	0.018	0.013	0.013	NA	-0.002	1.9e-02	3.9e-02	3.9e-02	NA	4.7e-01
13	TCGA	Soft Tissue Sarcoma	0.2120	0.1300	3.4e-04	0.023	0.023	0.046	NA	-0.002	1.5e-02	1.5e-02	9.9e-04	NA	4.6e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Tinnitus: Yes, but not now, but have in the past	14.6	15.6	21.2	4.3	2.6	3.7	4.6	4.1	4.5	4.5	4.2	4.2	2.0	4.3	4.3	3.0
Blood Platelet Count	14.5	168.1	453.7	-12.9	-8.3	-11.0	-11.6	-12.0	-12.5	-8.9	-12.1	-5.8	-21.3	-11.8	-12.2	-19.8
LDL Cholesterol	8.6	13.6	39.8	6.3	5.2	6.0	6.0	6.2	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
High cholesterol (Self-reported)	6.6	11.8	23.2	3.5	2.2	3.9	4.8	3.7	3.4	3.9	3.7	4.0	0.4	3.6	3.5	1.6
Hair/balding pattern: Pattern 2	6.2	7.9	13.3	2.9	0.1	2.2	3.6	2.7	2.9	2.4	2.7	2.3	3.3	2.9	2.9	3.6
Hair/balding pattern: Pattern 4	6.0	14.6	25.3	-4.0	-0.4	-3.9	-5.0	-4.0	-3.8	-3.8	-3.9	-3.8	-3.2	-4.1	-4.1	-3.9
Tense / ‘highly strung’	5.6	9.3	14.6	3.8	1.8	3.3	3.8	3.2	3.1	3.2	3.2	2.9	1.7	3.2	3.1	2.3
Comparative body size at age 10	5.2	14.5	19.4	-4.4	-3.5	-3.8	-3.5	-4.2	-4.3	-4.0	-4.3	-3.5	-2.4	-4.0	-4.0	-3.2
Impedance of leg (right)	4.8	23.1	30.1	5.2	3.9	4.5	5.5	5.1	5.2	5.2	5.0	5.2	2.5	5.2	5.2	3.7
Major Depression (MDD)	4.7	5.7	9.3	-2.7	-2.0	-2.8	-2.7	-2.6	-2.7	-3.1	-2.6	0.0	-0.2	-2.8	-2.8	-1.2
Hearing difficulty/problems: Yes	4.7	7.2	9.8	-3.1	-2.9	-2.8	-1.4	-2.9	-3.0	-2.8	-2.9	-2.6	-1.8	-2.8	-2.8	-2.4
Medication: Lisinopril	4.7	6.1	8.5	-2.5	-1.3	-2.5	-1.8	-2.7	-2.9	-2.7	-2.7	-2.3	-2.1	-2.7	-2.7	-2.5
Number of incorrect matches in round	4.6	7.6	9.8	2.6	3.1	2.6	1.8	3.1	3.0	2.9	3.0	2.6	2.2	3.0	3.0	2.6
Ever depressed for a whole week	4.4	5.4	9.9	2.2	1.4	3.1	2.3	2.4	2.5	2.6	2.4	2.6	1.1	2.6	2.6	1.8
Heel bone mineral density (BMD) T-score, automated (right)	4.2	9.7	14.3	-3.0	-3.1	-2.7	-3.8	-3.2	-3.3	-3.0	-3.2	-2.7	-2.7	-3.2	-3.2	-3.1
Impedance of leg (left)	4.1	19.9	24.9	4.9	3.6	4.4	5.0	4.7	4.8	4.8	4.7	4.8	2.4	4.8	4.8	3.5
Breastfed as a baby	4.1	5.1	8.2	-2.4	-2.5	-2.0	-2.9	-2.1	-2.3	-2.0	-2.1	-1.6	-2.3	-2.2	-2.2	-2.5
Had menopause	3.9	4.9	8.2	2.3	1.9	2.0	2.9	2.4	2.2	2.3	2.4	2.4	1.1	2.3	2.3	1.7
Mouth/teeth dental problems: Dentures	3.9	6.5	9.3	-2.9	-2.7	-2.5	-2.2	-2.3	-2.8	-2.3	-2.3	-1.9	-2.8	-2.5	-2.6	-3.1
Average weekly champagne plus white wine intake	3.9	5.4	10.6	-2.2	-1.5	-2.4	-3.3	-2.4	-2.3	-2.5	-2.4	-2.6	-1.0	-2.5	-2.5	-1.6
Mouth/teeth dental problems: Bleeding gums	3.7	4.8	6.3	2.3	1.6	2.0	2.4	2.2	2.4	2.0	2.3	1.5	2.4	2.2	2.2	2.5
Length of working week for main job	3.5	3.8	5.4	-1.8	-1.8	-1.9	-1.8	-1.9	-2.1	-1.9	-2.0	-1.6	-2.2	-2.0	-2.1	-2.3
Heel T-Score	3.4	27.3	44.8	-5.8	-4.1	-5.1	-6.7	-5.4	-5.4	-5.2	-5.5	-5.0	-3.6	-5.4	-5.4	-4.6
Cholesterol lowering medication	3.4	5.1	10.0	2.4	1.7	2.7	3.2	2.4	2.2	2.5	2.4	2.5	-0.0	2.2	2.2	0.8
Forced vital capacity (FVC), Best measure	3.2	11.7	16.7	3.5	3.0	3.6	1.7	3.6	4.1	3.7	3.6	3.1	3.0	3.7	3.8	3.5
Heel bone mineral density (BMD) T-score, automated (left)	3.1	7.1	10.4	-2.7	-2.5	-2.3	-3.2	-2.8	-3.0	-2.8	-2.8	-2.8	-1.7	-2.8	-2.9	-2.3
Forced vital capacity (FVC)	3.1	11.8	16.0	3.9	3.1	3.8	1.6	3.6	4.0	3.8	3.6	3.3	2.5	3.7	3.7	3.2
Forced expiratory volume in 1-second (FEV1)	3.1	10.5	15.0	3.7	3.3	3.4	1.5	3.3	3.9	3.5	3.4	3.0	2.5	3.4	3.5	3.2
Average weekly fortified wine intake	3.0	3.6	5.3	1.8	1.3	2.0	1.5	2.0	2.0	1.8	2.0	1.5	2.2	2.0	2.0	2.3
Hypothyroidism (self reported)	2.9	6.7	9.6	2.6	1.8	2.6	3.1	2.9	2.9	2.7	2.9	2.5	1.5	2.7	2.7	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.9	9.3	14.0	3.2	2.8	3.1	1.5	3.1	3.7	3.4	3.2	2.8	2.5	3.3	3.3	3.1
Alzheimer’s Disease (in mother)	2.8	3.3	4.5	2.1	0.6	2.0	1.2	2.1	2.1	2.1	2.1	1.8	1.1	2.1	2.1	1.4
Prostate Cancer	2.8	4.0	9.9	1.6	3.2	1.2	1.4	2.1	1.9	1.9	2.2	1.8	1.8	2.1	2.1	2.0
Angina	2.8	3.7	5.7	-2.3	-1.6	-2.0	-1.0	-2.3	-1.9	-2.1	-2.2	-2.4	-0.7	-2.1	-2.1	-1.2
Angina (self-reported)	2.8	3.7	5.7	-2.3	-1.6	-2.0	-1.0	-2.3	-1.9	-2.1	-2.2	-2.4	-0.6	-2.1	-2.1	-1.2
Chronotype (morning person)	2.7	6.2	11.6	-2.4	-1.9	-2.7	-3.4	-2.5	-2.8	-2.5	-2.6	-2.0	-2.0	-2.5	-2.5	-2.3
Birth weight	2.7	5.8	9.4	-2.2	-2.0	-2.4	-3.1	-2.3	-2.1	-1.9	-2.3	-2.1	-2.8	-2.5	-2.5	-2.9
Mouth/teeth dental problems: Loose teeth	2.7	3.2	5.1	-2.0	-1.8	-1.6	-1.2	-2.3	-1.8	-1.7	-2.2	-1.5	-1.6	-1.9	-1.8	-1.7
Medication: Co-codamol	2.6	3.0	3.9	-1.8	-2.0	-1.9	-1.2	-1.7	-1.8	-1.6	-1.8	-1.8	-1.4	-1.9	-1.9	-1.8
Past tobacco smoking	2.6	4.8	6.7	2.6	2.4	1.7	0.6	2.4	2.2	2.1	2.4	2.3	1.9	2.5	2.5	2.3
Smoking status: Previous	2.6	3.8	5.8	-2.4	-1.9	-1.4	-0.8	-2.1	-1.8	-1.8	-2.1	-2.1	-1.8	-2.2	-2.2	-2.2
Smoking Status	2.5	6.0	10.1	-2.6	-2.5	-2.3	-0.8	-2.5	-2.4	-2.0	-2.5	-1.9	-3.1	-2.5	-2.6	-3.2
Hypothyroidism/myxoedema (self-reported)	2.5	4.9	8.1	2.2	1.0	2.4	2.9	2.3	2.5	2.2	2.2	1.8	1.9	2.2	2.3	2.2
Medication: Blood pressure	2.5	4.4	5.9	-2.3	-1.7	-1.9	-1.6	-2.2	-2.4	-2.0	-2.2	-1.7	-2.2	-2.2	-2.2	-2.4
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.2	7.0	2.6	1.3	2.5	1.8	2.5	2.3	2.4	2.5	2.6	1.4	2.6	2.6	2.0
Financial situation satisfaction	2.5	3.1	6.0	2.0	0.9	2.0	2.4	1.9	1.6	1.8	1.8	2.0	0.7	1.8	1.8	1.2
Hearing difficulty/problems with background noise	2.3	3.7	5.2	-2.2	-1.6	-1.8	-0.6	-2.2	-2.1	-1.9	-2.1	-1.5	-2.2	-2.0	-2.0	-2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.3	3.0	6.0	2.4	0.5	2.4	2.1	1.8	1.9	2.0	1.9	1.6	0.3	1.7	1.7	0.7
Number of full sisters	2.1	2.6	5.4	-1.3	-2.3	-1.8	-0.9	-1.5	-1.4	-1.4	-1.5	-1.7	-1.6	-1.7	-1.7	-1.8
Impedance of whole body	2.1	10.6	14.0	3.7	2.2	3.1	3.6	3.4	3.7	3.5	3.4	3.5	1.8	3.5	3.5	2.7
Severe depression (siblings)	2.0	2.2	3.6	1.6	1.2	1.3	0.7	1.7	1.8	1.8	1.7	1.9	0.6	1.7	1.7	1.1
Pulse rate	1.9	3.1	5.9	-1.9	-1.8	-1.2	-0.8	-1.6	-1.9	-1.4	-1.7	-1.6	-2.2	-1.8	-1.9	-2.4
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	3.7	1.7	1.2	1.6	1.4	1.6	1.3	1.7	1.6	1.9	0.0	1.6	1.6	0.5
Friendships satisfaction	1.9	2.4	4.8	-1.2	-2.2	-1.3	-1.6	-1.8	-1.4	-1.8	-1.8	-1.8	0.5	-1.5	-1.5	-0.1
Tinnitus: Yes, now most or all of the time	1.9	2.3	3.5	-1.2	-1.9	-1.6	-1.7	-1.4	-1.5	-1.7	-1.5	-1.7	-0.6	-1.6	-1.6	-1.0
Pack years adult smoking proportion	1.8	2.8	7.6	-1.5	-1.7	-1.5	-1.0	-1.5	-1.8	-1.1	-1.5	-0.8	-2.8	-1.5	-1.6	-2.6
Alcohol usually taken with meals	1.8	2.9	6.9	-1.7	0.0	-1.3	-2.6	-1.6	-1.8	-1.6	-1.6	-1.2	-1.9	-1.7	-1.7	-2.0
Handedness (chirality/laterality): Left-handed	1.8	2.2	4.2	1.4	0.8	1.8	2.1	1.4	1.5	1.8	1.4	2.0	-0.1	1.6	1.6	0.6
Ever smoked	1.8	3.1	4.7	-2.2	-1.6	-1.4	-0.9	-2.0	-1.9	-1.7	-2.0	-1.7	-1.6	-1.9	-1.9	-1.8
Verbal and Numeric Reasoning (VNR)	1.7	4.2	5.3	2.0	2.3	2.0	1.7	2.3	2.1	2.2	2.2	2.3	1.0	2.3	2.3	1.5
Breast Cancer	1.7	4.0	5.1	1.8	2.1	2.0	1.2	2.1	2.0	2.0	2.1	1.6	2.2	2.1	2.1	2.3
Number of full brothers	1.7	2.1	5.2	1.4	0.7	1.8	2.3	1.4	1.4	1.6	1.4	2.0	-0.3	1.5	1.4	0.4
Knee pain experienced in last month	1.7	2.6	3.5	-1.8	-1.5	-1.6	-0.9	-1.9	-1.8	-1.7	-1.8	-1.5	-1.2	-1.7	-1.7	-1.5
Ever highly irritable/argumentative for 2 days	1.6	1.9	4.5	1.4	0.8	1.4	2.1	1.4	1.4	1.6	1.4	1.6	-0.1	1.4	1.4	0.5
Worry (Nagel 2018)	1.5	3.1	5.3	2.3	0.8	2.1	2.3	1.7	1.9	2.2	1.8	1.8	0.3	1.8	1.8	0.9
Mean Putamen Volume	1.5	1.7	3.1	-1.8	-0.5	-1.4	-1.2	-1.5	-1.6	-1.6	-1.5	0.0	-0.3	-1.5	-1.5	-0.9
Primary Biliary Cirrhosis	1.5	2.1	5.7	-1.4	-2.4	-1.8	-0.6	-1.3	-1.3	-1.0	-1.3	-1.0	-1.7	-1.3	-1.3	-1.7
Triglycerides	1.5	2.4	12.7	2.4	1.9	2.0	3.6	2.2	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Diabetes (mother)	1.5	1.9	5.4	-1.1	-2.3	-1.3	-0.1	-1.3	-1.1	-1.2	-1.3	-1.6	-1.1	-1.5	-1.5	-1.3
Medication: Simvastatin	1.5	2.2	6.1	1.1	-0.0	1.5	2.5	1.6	1.6	1.8	1.6	1.8	-0.0	1.6	1.5	0.5
Standing height	1.5	14.7	22.1	4.4	2.8	4.4	1.0	4.5	4.2	4.7	4.5	4.4	1.2	4.3	4.3	2.4
Medication: Amlodipine	1.5	2.1	3.6	-1.5	-1.6	-1.4	-0.3	-1.3	-1.8	-1.3	-1.4	-0.9	-1.8	-1.4	-1.5	-1.9
Illnesses of father: Heart disease	1.5	2.1	3.0	1.7	1.1	1.5	1.5	1.5	1.5	1.4	1.5	1.4	1.2	1.5	1.5	1.5
Pack years of smoking	1.5	2.3	5.9	-1.5	-1.3	-1.4	-1.0	-1.3	-1.6	-1.0	-1.3	-0.7	-2.4	-1.4	-1.4	-2.3
Rheumatoid Arthritis	1.4	1.9	3.7	-1.6	-0.7	-1.2	-1.5	-1.7	-1.7	-1.9	-1.7	0.0	-0.0	-1.6	-1.5	-0.5
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.4	1.0	0.6	1.4	1.5	1.1	1.4	1.0	1.1	0.8	1.8	1.2	1.3	1.9
Qualifications: None of the above	1.4	3.0	6.9	-1.6	-2.6	-1.8	-0.1	-1.7	-1.6	-1.7	-1.7	-1.7	-1.5	-1.8	-1.8	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	4.2	1.4	1.0	2.0	0.7	1.3	1.4	1.4	1.3	1.6	0.3	1.4	1.4	0.8
Migraine (self-reported)	1.4	1.7	3.3	1.3	0.8	1.2	1.8	1.2	1.4	1.2	1.2	1.4	1.1	1.4	1.4	1.3
Ever had bowel cancer screening	1.4	1.7	3.8	-1.0	-1.9	-1.2	-1.5	-1.3	-1.2	-1.5	-1.3	-1.7	0.4	-1.3	-1.3	-0.2
Miserableness	1.4	2.4	6.1	-1.1	-2.5	-1.0	-0.8	-1.6	-1.6	-1.3	-1.6	-1.1	-1.8	-1.5	-1.5	-1.9
Vascular/heart problems diagnosed by doctor	1.4	3.7	10.5	2.0	0.7	1.3	1.2	1.6	2.0	1.4	1.6	1.2	3.2	1.9	2.0	3.2
Intelligence (Savage-Jansen 2018)	1.3	4.0	5.0	1.9	1.8	1.9	1.4	2.2	2.2	1.9	2.0	2.1	1.8	2.2	2.2	2.2
Alzheimer’s Disease (including proxy)	1.3	1.8	3.0	1.5	0.5	1.7	0.9	1.6	1.5	1.6	1.5	1.4	0.8	1.5	1.5	1.0
Height	1.3	25.9	34.7	5.7	3.8	5.8	1.0	5.8	5.6	5.9	5.9	5.5	2.9	5.8	5.7	4.1
Exposure to tobacco smoke at home	1.3	1.4	4.3	1.3	0.5	1.0	2.1	1.3	1.4	1.3	1.3	1.1	0.2	1.1	1.1	0.5
Peak expiratory flow (PEF)	1.3	3.0	5.6	1.9	2.4	1.8	0.7	1.7	2.0	1.7	1.7	1.3	1.5	1.7	1.7	1.8
Medication: Paracetamol	1.3	2.1	3.4	1.2	0.8	1.9	1.6	1.6	1.4	1.5	1.6	1.6	0.8	1.6	1.6	1.1
Commuting to job workplace: Cycle	1.3	1.6	3.0	-1.2	-0.8	-1.7	-1.2	-1.2	-1.2	-1.7	-1.2	-1.6	0.8	-1.3	-1.2	0.2
Lung FVC	1.2	6.1	8.8	2.8	2.4	2.9	1.0	2.6	3.0	2.8	2.7	2.2	1.6	2.6	2.6	2.2
Diabetes (father)	1.2	1.5	3.1	1.4	1.3	1.5	1.8	1.0	1.2	0.9	1.0	0.8	1.3	1.1	1.1	1.4
Medication: Cholesterol lowering	1.2	1.9	6.0	1.1	-0.4	1.5	2.5	1.4	1.2	1.4	1.4	1.6	0.5	1.4	1.4	0.8
Lung cancer (father)	1.2	1.4	4.1	-1.1	-0.7	-1.3	-1.0	-1.1	-1.0	-1.6	-1.1	-2.0	0.7	-1.4	-1.3	0.0
Pulse wave reflection index	1.2	1.5	4.1	1.2	0.6	0.9	1.4	1.0	1.2	0.7	1.1	0.5	2.0	1.1	1.1	1.9
Breast cancer (self-reported)	1.2	1.5	2.7	-1.6	-1.2	-1.2	-1.4	-1.1	-1.1	-1.2	-1.1	-1.3	-0.8	-1.2	-1.2	-1.1
Taking other prescription medications	1.1	1.7	4.5	1.6	0.3	1.3	2.1	1.4	1.4	1.5	1.4	1.5	-0.2	1.3	1.3	0.4
High blood pressure	1.1	3.1	12.2	-1.6	-0.4	-0.9	-1.2	-1.3	-1.7	-1.0	-1.4	-0.6	-3.5	-1.6	-1.6	-3.2
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	3.0	0.9	0.2	1.7	0.7	1.1	1.1	1.0	1.1	0.8	1.5	1.2	1.2	1.5
Eye problems/disorders: Cataract	1.1	1.2	2.6	0.9	0.5	1.6	1.0	1.2	1.0	0.9	1.2	1.0	1.2	1.2	1.2	1.3
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.0	0.9	1.1	0.9	1.7	1.3	1.0	1.2	1.3	1.1	0.3	1.1	1.1	0.6
Medication: Atenolol	1.0	1.2	2.8	-1.2	-0.5	-1.3	-0.3	-1.0	-1.1	-1.0	-1.0	-0.6	-1.7	-1.1	-1.1	-1.6
Impedance of arm (left)	1.0	4.6	6.9	2.6	1.2	2.0	2.2	2.2	2.6	2.3	2.2	2.3	1.2	2.3	2.3	1.9
Hypertension (Self-reported)	1.0	2.7	11.6	-1.4	-0.2	-0.7	-1.1	-1.2	-1.5	-0.8	-1.2	-0.4	-3.4	-1.4	-1.5	-3.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	4.2	1.2	1.6	1.5	0.4	1.2	1.9	1.4	1.2	0.9	1.9	1.4	1.5	2.0
Myopia	1.0	1.5	2.5	1.3	-0.5	1.6	0.5	1.5	1.2	1.2	1.5	1.3	0.9	1.4	1.4	1.0
Blood Red Count	0.9	8.7	15.3	2.7	2.4	2.5	3.2	3.0	3.0	2.3	3.0	2.0	3.9	2.9	3.0	3.9
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.7	-1.0	0.3	-0.9	0.1	-1.0	-1.1	-0.9	-1.0	-1.0	-1.2	-1.2	-1.2	-1.3
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.1	1.4	1.1	1.2	0.9	1.0	1.0	1.1	1.0	1.4	0.7	1.2	1.2	1.1
Asthma	0.9	1.9	3.0	1.5	0.6	1.7	1.0	1.7	1.1	1.2	1.6	1.2	1.3	1.5	1.5	1.3
Leg fat percentage (right)	0.9	3.4	9.0	1.8	1.3	2.1	3.0	1.8	1.6	1.9	1.8	2.3	0.3	1.9	1.8	0.9
Suffer from ‘nerves’	0.9	1.4	4.6	1.4	-0.1	1.1	2.1	1.0	1.1	1.3	1.1	1.1	0.8	1.2	1.2	1.0
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.3	1.2	0.8	1.3	1.5	1.4	1.3	1.1	1.3	0.4	1.4	1.1	1.0	1.2
Wears glasses or contact lenses	0.9	1.0	2.0	1.1	0.7	1.4	1.2	0.9	1.1	1.1	1.1	1.1	0.5	1.0	1.0	0.8
Hearing aid user	0.9	1.0	6.2	-0.9	-0.2	-0.4	-0.1	-0.7	-0.8	0.1	-0.7	0.5	-2.5	-0.4	-0.5	-2.0
Average weekly beer plus cider intake	0.9	1.2	6.1	1.0	-0.0	0.7	2.5	1.0	1.0	1.2	1.1	1.2	0.0	1.1	1.1	0.4
Fluid intelligence score	0.8	1.6	3.0	0.9	1.7	1.1	0.6	1.4	1.2	1.2	1.3	1.4	1.1	1.5	1.5	1.3
Noisy workplace	0.8	1.0	2.1	1.2	-0.2	1.0	1.3	0.9	1.1	1.5	0.9	1.3	-1.1	0.9	0.9	-0.5
Illnesses of mother	0.8	1.0	3.3	0.8	1.2	0.6	-0.1	0.8	1.1	0.8	0.9	0.3	1.8	0.9	0.9	1.7
Gout (self-reported)	0.8	1.1	1.8	1.2	1.1	1.4	1.0	1.1	1.1	1.2	1.1	0.9	0.3	1.0	1.0	0.5
Overall health rating	0.8	1.7	5.6	1.3	0.0	1.4	2.4	1.3	1.2	1.3	1.3	1.4	0.4	1.3	1.3	0.8
Qualifications: nursing, teaching	0.8	1.2	6.8	0.3	1.1	-0.1	-0.3	0.8	0.7	0.2	0.7	-0.1	2.6	0.7	0.7	2.2
Medication for cholesterol	0.8	1.1	3.0	-0.8	-1.1	-1.1	-1.0	-0.9	-0.6	-1.2	-0.9	-1.5	1.7	-0.8	-0.7	1.0
Guilty feelings	0.8	1.2	2.0	1.4	0.5	1.2	1.3	1.2	1.3	1.1	1.2	0.8	0.8	1.1	1.1	1.0
Eye problems/disorders: Glaucoma	0.8	1.0	1.7	-1.0	0.1	-0.4	-0.5	-1.1	-1.3	-1.1	-1.2	-0.9	-0.9	-1.2	-1.2	-1.1
Townsend deprivation index at recruitment	0.7	1.0	1.5	-1.2	0.1	-0.9	-0.0	-1.0	-1.2	-1.2	-1.1	-1.1	-0.8	-1.2	-1.2	-1.0
Fed-up feelings	0.7	1.4	6.3	1.5	0.5	1.1	2.5	0.8	1.1	1.2	0.8	1.1	0.0	1.0	1.0	0.5
Supplements: Glucosamine	0.7	0.9	4.2	-1.3	-0.3	-0.7	-2.0	-0.7	-0.9	-0.7	-0.7	-0.6	-0.8	-0.7	-0.7	-0.9
Medication: Levothyroxine sodium	0.7	1.3	3.1	1.2	-0.1	1.2	1.8	1.1	1.5	1.2	1.1	0.7	0.9	1.1	1.1	1.0
High blood pressure (mother)	0.7	0.9	1.6	-0.8	0.1	-0.8	-0.3	-1.1	-1.1	-1.1	-1.1	-0.6	-1.3	-1.0	-1.0	-1.2
Neuroticism score	0.7	1.5	3.5	1.9	-0.3	1.5	1.8	1.1	1.2	1.4	1.2	1.2	-0.0	1.1	1.1	0.4
Impedance of arm (right)	0.7	3.3	6.2	2.1	0.9	1.7	2.5	1.8	2.2	1.9	1.8	1.9	0.9	1.9	1.9	1.5
Depression (self-reported)	0.7	0.8	3.9	0.8	-0.3	0.7	0.6	0.4	0.5	1.0	0.4	1.2	-2.0	0.5	0.4	-1.2
Prospective memory result	0.7	0.8	1.6	-0.8	0.1	-0.9	-0.8	-1.0	-1.1	-1.3	-1.0	-1.3	0.1	-1.1	-1.0	-0.3
Medication: Allopurinol	0.7	0.9	1.7	1.3	0.6	1.0	1.2	1.0	1.0	1.2	1.0	1.1	-0.2	0.9	0.9	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.7	0.7	-0.0	1.2	1.4	0.7	0.8	0.4	0.7	-0.0	1.6	0.6	0.6	1.4
Asthma (self-reported)	0.7	1.4	2.3	1.3	0.2	1.5	0.7	1.4	1.0	1.1	1.4	1.0	1.2	1.3	1.3	1.1
Medication: Aspirin	0.7	1.0	3.3	-0.6	-1.7	-0.7	0.1	-0.7	-0.6	-0.3	-0.7	-0.4	-1.8	-0.7	-0.8	-1.6
Alcohol drinker status: Never	0.7	0.8	2.2	-0.9	-1.5	-1.0	-1.3	-0.6	-0.8	-0.7	-0.6	-0.8	-0.8	-0.8	-0.8	-0.9
Number of operations (self-reported)	0.7	1.0	1.9	1.0	1.1	1.4	0.7	0.9	1.1	0.8	0.9	0.7	1.1	0.9	0.9	1.2
Basal cell carcinoma (self-reported)	0.7	0.9	3.1	-1.1	0.6	-1.0	0.1	-0.9	-0.7	-0.4	-0.9	-0.2	-1.8	-0.7	-0.7	-1.5
Heart attack/myocardial infarction (self-reported)	0.7	0.8	1.8	-1.0	-0.4	-0.5	0.3	-0.9	-0.9	-0.8	-0.9	-1.0	-1.2	-1.1	-1.1	-1.4
Schizophrenia (2014)	0.6	1.3	2.3	-1.3	-1.0	-1.2	-0.6	-1.4	-1.3	-1.5	-1.4	0.0	-0.0	-1.4	-1.4	-0.5
Systolic Blood Pressure	0.6	2.8	8.1	-1.1	-0.1	-1.2	-1.7	-1.6	-1.6	-1.2	-1.6	-0.9	-2.8	-1.7	-1.7	-2.6
Leg fat mass (right)	0.6	2.2	4.5	1.6	1.0	2.0	2.1	1.5	1.3	1.6	1.5	1.9	-0.1	1.5	1.5	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.6	0.6	0.7	0.4	0.8	1.0	0.8	1.0	1.0	1.3	-0.1	1.0	1.0	0.2
Leg fat percentage (left)	0.6	2.2	6.4	1.5	1.0	1.9	2.5	1.4	1.2	1.4	1.4	1.8	0.1	1.4	1.4	0.6
Schizophrenia (2018)	0.5	1.0	1.9	-1.4	-0.6	-0.8	-0.3	-1.1	-1.2	-1.4	-1.2	0.0	-0.1	-1.3	-1.2	-0.5
Schizophrenia vs Biploar Disorder	0.5	0.6	1.2	-0.8	-0.7	-1.1	-0.5	-1.0	-0.9	-1.0	-0.9	0.0	-0.0	-0.9	-0.9	-0.4
Waist Hip Ratio (WHR)	0.5	2.1	4.4	-1.5	-1.1	-1.3	-1.2	-1.2	-1.6	-1.1	-1.3	-0.9	-2.1	-1.4	-1.5	-2.1
Neuroticism	0.5	1.2	2.5	1.6	-0.1	1.4	1.3	1.0	1.1	1.4	1.0	1.3	-0.7	1.0	1.0	-0.1
Chronic bronchitis/emphysema (father)	0.5	0.6	2.2	0.7	0.7	0.8	0.6	0.5	0.7	0.4	0.5	0.0	1.5	0.5	0.6	1.3
Allergy	0.5	1.1	2.5	-1.4	0.9	-1.6	-0.9	-1.2	-0.7	-0.9	-1.2	-1.0	-0.5	-1.0	-1.0	-0.6
Father’s age at death	0.5	0.7	2.3	-0.6	-0.7	-0.5	-1.5	-0.8	-0.6	-0.9	-0.7	-1.2	0.6	-0.8	-0.8	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	4.5	0.7	0.1	0.9	2.1	0.9	0.7	0.9	0.8	0.7	-0.2	0.7	0.7	0.0
Exposure to tobacco smoke outside home	0.5	0.7	5.0	-0.5	-2.2	-0.4	0.7	-0.5	-0.6	-0.4	-0.5	-0.1	-1.1	-0.5	-0.5	-0.9
Eye problems/disorders: None of the above	0.5	0.5	1.4	-0.7	-1.0	-1.2	-0.9	-0.7	-0.6	-0.7	-0.7	-0.5	-0.5	-0.6	-0.6	-0.5
Medication for pain relief, constipation, heartburn	0.5	0.9	6.3	0.7	0.4	-0.1	-0.0	0.3	0.5	-0.1	0.3	-0.3	2.5	0.4	0.5	2.0
Pulse rate, automated reading	0.5	1.6	3.2	-1.4	-1.2	-0.9	-0.0	-1.1	-1.6	-1.1	-1.2	-1.1	-1.6	-1.4	-1.4	-1.8
Commuting to job workplace: Walk	0.5	0.5	1.3	-0.6	-0.5	-0.2	-1.1	-0.7	-0.6	-0.6	-0.7	-0.6	-0.8	-0.7	-0.7	-0.8
Osteoporosis (self-reported)	0.5	0.6	3.6	0.4	0.8	0.1	0.5	0.4	0.5	-0.0	0.4	-0.2	1.9	0.4	0.5	1.6
Number of self-reported non-cancer illnesses	0.5	0.9	2.5	0.8	0.5	1.2	1.6	1.1	0.8	0.9	1.1	0.9	0.3	0.9	0.8	0.5
Mother’s age at death	0.5	0.7	2.8	-0.6	-1.0	-1.1	-1.7	-0.7	-0.6	-0.5	-0.7	-0.6	-0.6	-0.6	-0.7	-0.6
Commuting to job workplace: Public transport	0.5	0.6	4.1	0.6	0.5	0.5	-0.2	0.4	0.3	-0.1	0.5	-0.2	2.0	0.4	0.4	1.6
Medication: Blood pressure	0.5	0.9	3.4	-0.8	0.0	-0.6	-0.6	-0.5	-0.9	-0.6	-0.6	-0.3	-1.9	-0.8	-0.9	-1.7
Medication: Bendroflumethiazide	0.5	0.8	4.3	-0.9	-0.8	-0.4	0.3	-0.6	-0.3	-0.0	-0.7	-0.2	-2.1	-0.6	-0.7	-1.7
Ever had prostate specific antigen (PSA) test	0.5	0.5	3.8	-0.0	-0.8	0.2	-2.0	-0.1	0.1	-0.2	-0.1	-0.5	1.2	-0.0	-0.0	0.9
Age started oral contraceptive pill	0.5	0.6	2.8	0.0	1.2	0.1	0.6	0.5	0.5	0.2	0.5	0.2	1.7	0.6	0.6	1.5
Leg fat mass (left)	0.5	1.8	3.6	1.4	0.9	1.9	1.9	1.4	1.1	1.4	1.4	1.7	-0.2	1.3	1.3	0.3
Neuroticism (2016)	0.4	0.5	2.7	-0.6	-1.6	0.0	-0.6	-0.6	-0.6	-0.2	-0.9	-0.2	-1.0	-0.4	-0.4	-1.0
BMI	0.4	2.1	3.4	-1.8	-1.0	-1.2	-1.0	-1.7	-1.6	-1.6	-1.7	-1.1	-1.3	-1.5	-1.5	-1.4
Cardiovascular Disease	0.4	1.4	8.4	0.3	0.9	0.8	1.0	0.4	0.2	1.0	0.4	1.3	-2.9	0.3	0.2	-2.0
Hand grip strength (left)	0.4	1.0	1.5	1.2	0.8	0.8	-0.0	1.1	1.0	1.1	1.1	0.8	1.2	1.1	1.1	1.2
Medication for hormone replacement therapy	0.4	0.4	0.8	0.1	0.7	0.6	0.9	0.6	0.5	0.9	0.7	0.8	-0.8	0.5	0.5	-0.5
Maternal smoking around birth	0.4	0.5	2.6	0.1	-0.9	-0.1	1.1	-0.4	-0.2	0.1	-0.4	0.1	-1.6	-0.3	-0.4	-1.3
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.8	1.2	-0.3	1.4	0.8	1.0	0.7	0.8	1.0	0.6	0.8	0.9	0.9	0.7
Sitting height	0.4	2.6	5.4	1.9	1.1	2.3	-0.2	1.8	1.7	2.2	1.8	2.0	-0.7	1.7	1.7	0.0
Body mass index (BMI)	0.4	1.6	2.5	-1.5	-1.1	-0.9	-0.4	-1.4	-1.6	-1.4	-1.4	-1.0	-1.3	-1.4	-1.4	-1.4
Trunk fat mass	0.4	1.9	3.7	1.5	0.8	1.9	1.4	1.5	1.2	1.5	1.5	1.8	-0.1	1.4	1.4	0.4
Heart attack	0.4	0.6	1.2	-0.8	-0.1	-0.4	0.4	-0.7	-0.7	-0.6	-0.7	-0.9	-1.0	-0.8	-0.9	-1.1
Pain all over the body in last month	0.4	0.5	1.8	-0.3	-1.0	-0.3	-0.5	-0.5	-0.3	-0.1	-0.5	-0.3	-1.3	-0.5	-0.5	-1.2
Falls in the last year	0.4	0.5	2.0	0.4	0.1	0.6	1.1	0.3	0.6	0.2	0.3	0.1	1.4	0.4	0.5	1.2
Loud music exposure frequency	0.4	0.4	1.3	0.5	0.1	0.3	1.1	0.7	0.8	0.6	0.6	0.6	0.5	0.6	0.7	0.7
Heart disease (mother)	0.4	0.5	1.5	0.5	0.1	0.9	0.8	0.6	0.4	0.8	0.6	1.2	-1.1	0.6	0.6	-0.5
Chest pain or discomfort	0.4	0.5	2.7	1.0	-0.2	0.6	1.6	0.7	0.6	0.6	0.7	0.5	0.3	0.6	0.6	0.5
Had major operations	0.4	0.5	0.8	0.6	0.9	0.7	0.5	0.7	0.9	0.7	0.7	0.7	0.3	0.7	0.7	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.9	0.4	0.6	0.8	0.7	0.2	0.9	1.0	0.3	0.8	-0.9	0.5	0.5	-0.4
Medication: Aspirin	0.4	0.5	2.6	-0.4	-1.1	-0.4	0.2	-0.5	-0.4	-0.0	-0.4	0.1	-1.6	-0.4	-0.4	-1.3
Ulcerative Colitis (UC)	0.3	0.6	1.3	-0.7	0.2	-1.1	-1.0	-0.8	-0.8	-0.7	-0.4	-0.3	-1.1	-0.7	-0.7	-1.0
Ovarian Cancer	0.3	0.5	1.5	0.9	1.2	0.9	0.3	0.5	0.7	0.6	0.6	0.6	0.2	0.6	0.6	0.4
HbA1C	0.3	0.3	1.7	0.8	0.5	1.3	0.7	1.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.3	2.5	13.0	1.4	-0.9	2.0	3.6	1.1	0.8	1.4	1.1	1.8	-1.1	1.1	1.1	-0.5
Number of treatments/medications taken	0.3	0.6	2.9	-0.5	-1.2	0.1	0.6	-0.2	-0.4	-0.0	-0.3	0.2	-1.7	-0.3	-0.4	-1.4
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.7	0.4	0.0	0.1	0.6	0.4	0.7	0.2	0.4	-0.6	1.3	0.2	0.2	1.0
Trunk fat percentage	0.3	1.4	3.1	1.3	0.6	1.6	1.7	1.2	1.0	1.2	1.2	1.6	-0.2	1.2	1.2	0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.7	0.7	0.6	0.7	0.4	0.5	0.5	0.4	0.4	0.1	0.8	0.5	0.5	0.8
Had other major operations	0.3	0.3	1.1	0.4	-0.2	1.0	1.0	0.4	0.5	0.3	0.3	0.1	0.9	0.4	0.4	0.7
Hair/balding pattern: Pattern 3	0.3	0.4	3.9	-0.3	2.0	0.5	-0.9	-0.0	-0.2	-0.0	-0.0	0.0	-0.4	-0.1	-0.1	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	2.0	0.6	0.2	0.6	0.2	0.2	0.5	0.8	0.3	1.1	-1.4	0.4	0.4	-0.7
Chronic bronchitis/emphysema (mother)	0.3	0.4	2.3	-0.1	-1.5	-0.3	0.6	-0.3	-0.6	-0.6	-0.3	-0.3	-0.5	-0.5	-0.5	-0.6
Body fat percentage	0.3	1.4	3.7	1.2	0.6	1.6	1.9	1.1	0.9	1.1	1.1	1.5	-0.1	1.1	1.1	0.4
Health satisfaction	0.3	0.4	3.3	0.1	-1.8	-0.3	0.5	-0.2	-0.2	-0.1	-0.2	-0.2	-0.6	-0.2	-0.2	-0.6
Qualifications: College or University degree	0.3	0.8	3.3	0.3	0.8	0.3	-1.6	0.5	0.3	0.1	0.5	0.2	1.8	0.6	0.6	1.5
Emphysema/chronic bronchitis	0.3	0.3	1.3	0.3	-1.1	0.4	0.6	0.2	-0.1	0.4	0.1	0.6	-1.1	0.2	0.1	-0.7
Medication: Ibuprofen	0.3	0.4	1.4	0.4	1.2	0.9	0.8	0.6	0.6	0.5	0.6	0.2	0.3	0.5	0.5	0.3
Whole body fat mass	0.3	1.1	2.5	1.1	0.6	1.6	1.3	1.1	0.9	1.1	1.1	1.5	-0.3	1.1	1.0	0.1
Family relationship satisfaction	0.3	0.4	1.6	0.5	-0.8	0.3	1.1	0.2	0.2	0.0	0.2	-0.4	1.3	0.2	0.2	0.9
Leg pain on walking	0.3	0.4	0.8	-0.6	-0.7	-0.4	0.7	-0.6	-0.5	-0.4	-0.6	-0.3	-0.9	-0.6	-0.6	-0.8
Illnesses of siblings: Diabetes	0.3	0.4	1.1	0.8	0.3	0.4	0.7	0.6	0.2	0.6	0.5	1.1	-0.9	0.5	0.5	-0.5
Leg fat-free mass (right)	0.3	1.6	6.5	-1.0	-1.1	-0.5	-2.5	-1.0	-1.3	-1.0	-1.0	-0.9	-1.2	-1.1	-1.2	-1.4
Average weekly red wine intake	0.3	0.4	1.0	-0.6	0.6	-0.4	-1.0	-0.6	-0.6	-0.8	-0.6	-0.4	0.7	-0.4	-0.4	0.4
Mood swings	0.3	0.6	0.8	-0.3	-0.9	-0.5	0.4	-0.8	-0.8	-0.8	-0.8	-0.9	-0.5	-0.9	-0.9	-0.7
Diabetes diagnosed by doctor	0.3	0.5	2.2	-0.4	-0.4	-0.4	0.7	-0.3	-0.6	-0.3	-0.4	0.1	-1.5	-0.5	-0.5	-1.3
Medication: Gliclazide	0.3	0.3	0.8	-0.9	-0.3	-0.4	0.3	-0.6	-0.6	-0.4	-0.6	-0.4	-0.5	-0.5	-0.5	-0.6
Leg predicted mass (right)	0.3	1.5	6.2	-0.9	-1.1	-0.5	-2.5	-1.0	-1.2	-0.9	-0.9	-0.8	-1.2	-1.1	-1.1	-1.4
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.7	0.4	0.1	0.7	-1.3	0.6	0.6	0.7	0.6	0.4	-0.0	0.5	0.5	0.1
Illnesses of father: High blood pressure	0.3	0.4	1.3	-0.7	0.2	-0.5	-0.6	-0.6	-0.6	-0.4	-0.6	-0.3	-1.1	-0.6	-0.6	-1.1
Fractured/broken bones in last 5 years	0.3	0.4	1.6	0.4	0.5	0.2	1.3	0.4	0.3	-0.1	0.4	-0.1	1.2	0.3	0.3	0.9
Heart disease (siblings)	0.3	0.4	0.5	-0.5	-0.7	-0.5	-0.4	-0.6	-0.7	-0.7	-0.6	-0.3	-0.7	-0.6	-0.6	-0.7
Neuroticism (Nagel 2018)	0.2	0.6	1.6	1.3	-0.1	1.0	1.1	0.5	0.8	0.8	0.6	0.4	0.5	0.6	0.7	0.6
Age at First Birth	0.2	0.4	1.2	1.1	1.0	0.7	1.0	0.9	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.2	0.2	0.5	-0.2	-0.1	-0.6	-0.4	-0.5	-0.7	-0.7	-0.6	0.0	-0.1	-0.7	-0.6	-0.3
Blood White Count	0.2	1.6	3.7	1.1	-0.9	1.5	1.5	1.2	1.1	1.5	1.1	1.9	-0.4	1.4	1.4	0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.6	-0.3	-0.1	-0.4	0.8	-0.3	-0.3	-0.2	-0.3	0.1	-1.3	-0.4	-0.4	-1.0
Average weekly spirits intake	0.2	0.2	0.6	-0.6	-0.6	-0.3	-0.8	-0.6	-0.4	-0.4	-0.5	0.0	0.5	-0.2	-0.1	0.4
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.9	0.6	-0.1	0.9	1.0	0.2	0.5	0.4	0.2	0.0	0.2	0.2	0.2	0.3
Vitamin and mineral supplements	0.2	0.3	1.3	-0.5	-0.7	-1.0	1.1	-0.4	-0.6	-0.4	-0.3	-0.1	-0.3	-0.3	-0.3	-0.3
Supplements: Zinc	0.2	0.3	0.8	0.6	0.5	0.5	0.5	0.3	0.5	0.7	0.3	0.6	-0.9	0.3	0.3	-0.5
Medication: Metformin	0.2	0.3	0.9	-0.5	-0.9	-0.3	0.5	-0.4	-0.5	-0.3	-0.4	-0.1	-0.9	-0.4	-0.4	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.2	0.6	0.2	0.5	1.1	0.4	0.6	0.5	0.3	0.3	0.1	0.4	0.4	0.2
Serious illness, injury or assault to yourself	0.2	0.2	1.2	0.1	-0.5	-0.1	0.5	0.2	0.1	-0.1	0.3	-0.3	1.1	0.1	0.1	0.8
Multivitamins +/- minerals	0.2	0.2	1.0	0.5	0.3	0.9	-1.0	0.3	0.6	0.4	0.2	-0.0	0.4	0.2	0.3	0.4
Stomach or abdominal pain in last month	0.2	0.3	2.8	-0.1	-1.7	-0.5	-0.1	-0.2	-0.1	-0.2	-0.1	-0.4	0.1	-0.2	-0.2	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	-0.1	-0.8	-0.4	0.9	-0.4	-0.2	-0.5	-0.4	-1.0	0.6	-0.5	-0.5	0.2
Financial difficulties in last 2 years	0.2	0.3	1.3	0.1	-0.9	-0.3	0.1	0.1	-0.2	-0.0	0.0	0.0	-1.1	-0.2	-0.3	-1.0
Mouth/teeth dental problems	0.2	0.2	0.6	-0.4	-0.0	-0.6	-0.8	-0.6	-0.4	-0.6	-0.6	-0.3	0.5	-0.4	-0.3	0.3
Illnesses of siblings	0.2	0.3	1.1	0.4	-0.0	0.3	0.5	0.5	0.6	0.4	0.5	0.0	1.1	0.4	0.4	0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.5	2.1	0.2	1.0	0.4	-1.3	0.2	0.4	0.1	0.3	-0.3	1.4	0.2	0.3	1.2
Medication: Lansoprazole	0.2	0.3	1.8	-0.1	-0.4	0.3	0.2	0.1	0.2	-0.2	-0.0	-0.4	1.4	0.1	0.1	1.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.3	-0.6	0.9	-0.6	-1.1	-0.6	-0.3	-0.5	-0.5	-0.7	0.2	-0.5	-0.4	0.1
Medication: Paracetamol	0.2	0.3	0.8	0.2	0.3	0.9	0.5	0.4	0.4	0.7	0.4	0.8	-0.7	0.5	0.4	-0.3
Glaucoma (self-reported)	0.2	0.2	1.4	0.3	1.2	0.8	0.4	-0.0	-0.0	-0.0	-0.1	0.3	0.2	0.1	0.1	0.3
Number of children fathered	0.2	0.2	0.7	-0.1	-0.1	-0.1	0.0	0.2	0.4	0.6	0.2	0.9	-0.7	0.4	0.4	-0.3
Age at first live birth	0.2	0.3	1.9	-0.4	1.4	-0.1	-0.8	-0.0	-0.3	-0.3	-0.1	-0.4	0.7	-0.1	-0.1	0.4
Neck or shoulder pain in last month	0.2	0.3	1.4	0.2	-0.7	0.6	1.2	0.3	0.1	0.1	0.3	0.5	0.4	0.4	0.4	0.4
Medication: Omeprazole	0.2	0.3	0.6	-0.3	-0.8	-0.2	-0.1	-0.4	-0.5	-0.4	-0.5	-0.4	-0.7	-0.6	-0.6	-0.7
Alcohol intake frequency.	0.2	0.5	1.6	-0.5	-1.2	-0.5	-1.2	-0.2	-0.5	-0.3	-0.3	-0.1	-1.1	-0.4	-0.4	-1.1
Loneliness, isolation	0.2	0.3	0.8	-0.1	-0.8	-0.3	-0.4	-0.7	-0.4	-0.6	-0.6	-0.9	-0.2	-0.7	-0.7	-0.4
Long-standing illness, disability or infirmity	0.2	0.3	0.7	-0.7	-0.4	-0.7	0.5	-0.3	-0.6	-0.4	-0.4	-0.4	-0.7	-0.5	-0.5	-0.8
Back pain experienced in last month	0.2	0.3	1.7	-0.2	-1.3	-0.5	0.5	-0.3	-0.3	-0.4	-0.3	-0.5	-0.2	-0.4	-0.4	-0.3
Mineral and other dietary supplements	0.2	0.3	3.1	0.3	0.7	-0.1	1.8	0.0	0.1	0.1	-0.0	0.3	0.3	0.2	0.2	0.4
Ever taken oral contraceptive pill	0.2	0.2	1.1	-0.6	0.1	-0.2	-0.1	-0.2	-0.4	-0.1	-0.2	-0.2	-1.0	-0.4	-0.4	-1.0
Pain type(s) experienced in last month: Hip pain	0.2	0.2	1.3	-0.3	-1.2	-0.3	-0.3	-0.4	-0.4	-0.4	-0.4	-0.4	0.4	-0.3	-0.3	0.1
Irritability	0.2	0.4	2.0	0.8	-0.4	0.9	1.4	0.5	0.4	0.7	0.5	0.3	-0.1	0.4	0.4	-0.0
Diastolic blood pressure, automated reading	0.2	0.7	2.0	-0.8	1.4	-0.5	-0.7	-0.5	-1.0	-0.6	-0.6	-0.4	-1.1	-0.7	-0.7	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	-0.6	-0.4	-0.5	-0.1	-0.5	-0.4	-0.4	-0.5	0.0	-0.7	-0.3	-0.3	-0.6
Alcohol drinker status: Previous	0.2	0.2	0.8	-0.9	-0.1	-0.4	-0.6	-0.3	-0.4	-0.4	-0.4	-0.2	-0.5	-0.4	-0.4	-0.5
Bipolar Disorder (2018)	0.1	0.2	1.0	0.2	0.9	0.3	1.0	0.2	0.5	0.4	0.3	0.0	0.1	0.4	0.4	0.3
Bipolar Disorder or Schizophrenia	0.1	0.4	0.9	-0.9	0.2	-0.5	0.4	-0.8	-0.6	-0.8	-0.8	0.0	0.0	-0.8	-0.7	-0.2
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.0	0.0	0.1	-0.2	-0.3	-0.5	-0.3	-0.3	-0.1	-0.3	-0.3	-0.3	-0.3
Irritable Bowel Disease (IBD)	0.1	0.2	1.0	-0.1	0.5	-0.3	-0.4	-0.4	-0.1	-0.1	-0.1	-0.2	-1.0	-0.4	-0.4	-0.8
Bipolar Disorder (2011)	0.1	0.1	0.4	-0.6	-0.0	-0.4	-0.4	-0.7	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.1	0.2	0.4	-0.4	-0.4	-0.1	-0.5	-0.6	-0.4	-0.6	-0.6	0.0	0.1	-0.6	-0.6	-0.1
HDL Cholesterol	0.1	0.2	0.9	0.7	0.5	1.0	-0.0	0.8	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Lupus	0.1	0.1	1.0	-0.0	-0.1	-0.3	1.0	-0.1	-0.1	-0.2	-0.2	-0.4	-0.1	-0.3	-0.3	-0.2
Allergy or Eczema	0.1	0.2	1.1	0.4	-1.1	0.6	0.1	0.3	0.2	0.2	0.3	0.0	0.4	0.3	0.3	0.3
Respiratory disease	0.1	0.3	1.4	0.3	-0.6	0.6	-0.4	0.7	0.1	0.1	0.6	0.0	1.2	0.4	0.4	0.9
Hair Pigment	0.1	2.0	4.3	-1.7	0.2	-1.4	0.5	-1.5	-1.5	-1.9	-1.4	-2.1	1.1	-1.5	-1.5	0.3
Relative age of first facial hair	0.1	0.1	0.5	0.1	0.3	-0.5	-0.5	-0.1	0.0	0.1	-0.0	0.5	-0.7	0.1	0.1	-0.4
Ever had hysterectomy (womb removed)	0.1	0.2	1.0	0.4	-0.1	0.6	1.0	-0.1	0.0	-0.2	-0.1	0.1	0.4	0.0	0.1	0.4
Systolic blood pressure, automated reading	0.1	0.3	2.4	0.3	1.6	0.5	-0.3	0.1	-0.1	0.1	0.0	0.2	-0.5	-0.0	-0.0	-0.4
Leg fat-free mass (left)	0.1	0.6	3.4	-0.5	-0.6	-0.0	-1.8	-0.4	-0.7	-0.4	-0.4	-0.3	-1.0	-0.5	-0.6	-1.0
Hand grip strength (right)	0.1	0.4	0.5	0.5	0.7	0.2	-0.7	0.7	0.7	0.7	0.7	0.3	0.6	0.6	0.6	0.6
Current tobacco smoking	0.1	0.1	0.6	-0.1	-0.5	-0.2	0.8	-0.0	-0.1	0.1	-0.0	0.5	-0.5	0.1	0.1	-0.3
Age when periods started (menarche)	0.1	0.3	0.6	0.5	-0.3	0.7	0.6	0.6	0.7	0.8	0.6	0.8	-0.2	0.6	0.6	0.1
Qualifications: CSEs or equivalent	0.1	0.1	0.3	-0.1	0.2	-0.2	-0.5	-0.2	-0.1	-0.1	-0.2	-0.0	-0.5	-0.2	-0.2	-0.4
Leg predicted mass (left)	0.1	0.6	3.3	-0.5	-0.6	0.0	-1.8	-0.4	-0.7	-0.4	-0.4	-0.3	-1.0	-0.5	-0.6	-1.0
Waist circumference	0.1	0.5	2.1	-0.7	-0.6	-0.1	-0.2	-0.5	-0.9	-0.5	-0.5	0.0	-1.4	-0.5	-0.6	-1.3
Nervous feelings	0.1	0.2	0.7	0.6	-0.2	0.8	0.8	0.3	0.4	0.5	0.4	0.3	0.0	0.3	0.3	0.1
Diabetes (self-reported)	0.1	0.2	1.8	0.0	0.1	-0.1	1.4	0.2	0.0	0.1	0.2	0.4	-0.5	0.1	0.1	-0.3
Weight	0.1	0.5	1.4	0.7	0.2	1.2	0.2	0.7	0.4	0.8	0.7	1.0	-0.7	0.7	0.6	-0.3
Arm fat percentage (right)	0.1	0.4	0.6	-0.7	-0.5	-0.1	0.6	-0.6	-0.8	-0.8	-0.6	-0.3	-0.6	-0.6	-0.6	-0.7
Trunk fat-free mass	0.1	0.7	1.7	0.6	0.9	1.0	-1.3	1.0	0.6	1.0	1.0	0.9	-0.1	0.8	0.8	0.1
Hip circumference	0.1	0.4	0.9	0.6	0.4	0.9	0.7	0.7	0.5	0.7	0.7	0.9	0.0	0.7	0.7	0.3
Time employed in main current job	0.1	0.1	0.2	-0.3	0.4	-0.2	-0.4	-0.3	-0.2	-0.2	-0.3	-0.3	-0.2	-0.3	-0.3	-0.2
Alcohol intake versus 10 years previously	0.1	0.2	0.6	0.3	-0.0	0.4	0.8	0.5	0.5	0.6	0.5	0.5	0.1	0.5	0.5	0.2
Worrier / anxious feelings	0.1	0.1	0.5	0.0	-0.4	-0.1	-0.7	-0.2	-0.3	-0.3	-0.2	-0.4	0.1	-0.3	-0.3	-0.1
Number of live births	0.1	0.2	0.8	-0.3	-0.9	-0.2	0.9	-0.3	-0.3	-0.1	-0.4	0.2	-0.6	-0.1	-0.1	-0.4
Happiness	0.1	0.2	1.1	0.5	-1.1	-0.1	0.1	-0.3	-0.1	-0.2	-0.2	-0.6	-0.2	-0.3	-0.3	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	1.2	-0.2	1.1	0.2	-0.3	-0.0	-0.1	-0.2	-0.1	-0.4	-0.2	-0.2	-0.2	-0.4
Pulse wave Arterial Stiffness index	0.1	0.1	0.4	0.3	-0.3	0.5	0.6	0.3	0.1	-0.0	0.2	-0.3	0.5	-0.0	-0.0	0.3
Trunk predicted mass	0.1	0.6	1.9	0.5	0.8	0.9	-1.4	0.9	0.6	0.9	0.9	0.8	-0.2	0.8	0.7	-0.0
Birth weight of first child	0.1	0.1	0.5	-0.1	0.7	0.5	-0.5	0.1	0.4	0.2	0.1	-0.2	0.6	0.1	0.1	0.6
Blood clot in the leg (DVT)	0.1	0.1	0.5	-0.5	-0.5	-0.2	0.1	-0.4	-0.3	-0.2	-0.4	0.3	-0.7	-0.2	-0.1	-0.5
Headache pain in last month	0.1	0.2	0.7	-0.9	0.1	-0.7	-0.2	-0.5	-0.3	-0.2	-0.4	-0.1	-0.7	-0.4	-0.4	-0.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.7	0.6	0.5	0.1	-0.8	0.1	0.3	0.1	0.1	-0.2	0.7	0.1	0.1	0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	0.1	0.1	0.0	0.2	0.2	0.1	0.4	0.1	0.6	-0.5	0.3	0.3	-0.4
High blood pressure (siblings)	0.1	0.2	0.5	0.3	0.7	0.6	0.1	0.5	0.4	0.4	0.5	0.5	0.2	0.5	0.5	0.3
Arm fat-free mass (right)	0.1	0.4	1.2	0.5	0.5	0.9	-1.1	0.8	0.3	0.7	0.7	0.6	-0.1	0.6	0.5	0.0
Wheeze or whistling in the chest in last year	0.1	0.2	1.7	-0.6	-1.3	-0.1	0.3	0.0	-0.5	-0.1	-0.0	0.2	-0.2	0.0	-0.0	-0.3
Pulse wave peak to peak time	0.1	0.1	0.4	0.0	0.5	-0.2	-0.6	0.1	0.2	0.3	0.1	0.5	-0.3	0.3	0.3	-0.1
Shortness of breath walking on level ground	0.1	0.2	0.4	0.6	-0.6	-0.1	0.3	0.2	0.2	0.4	0.3	0.5	-0.7	0.3	0.2	-0.4
Medication: Seretide 50 evohaler	0.1	0.1	1.0	-0.0	-1.0	-0.4	-0.5	0.1	0.1	0.0	0.1	-0.3	0.3	-0.0	-0.0	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.6	0.3	0.8	0.3	0.4	-0.1	-0.1	-0.1	-0.1	0.4	-0.2	0.1	0.1	-0.0
Arm predicted mass (right)	0.1	0.3	1.5	0.4	0.5	0.8	-1.2	0.6	0.2	0.5	0.6	0.5	-0.2	0.4	0.4	-0.1
Comparative height size at age 10	0.1	0.5	6.2	-0.3	-0.3	0.3	-2.5	-0.1	-0.3	-0.2	-0.1	-0.1	0.1	-0.1	-0.1	-0.0
Age at last live birth	0.1	0.2	0.8	0.2	0.9	0.1	-0.0	0.4	0.2	0.3	0.4	0.3	0.5	0.4	0.4	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.5	-0.2	0.3	-0.4	0.7	-0.1	-0.1	-0.1	-0.2	-0.1	-0.3	-0.2	-0.2	-0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.5	0.1	0.7	0.3	0.2	0.2	0.3	0.3	0.2	0.6	0.1	0.3	0.3	0.3
Supplements: Vitamin C	0.1	0.1	0.9	-0.2	0.2	-0.2	-1.0	-0.1	-0.2	-0.2	-0.1	-0.2	0.2	-0.1	-0.1	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.9	0.6	0.1	0.3	-0.1	0.1	0.3	-0.0	0.2	-0.3	0.9	0.1	0.1	0.7
Whole body fat-free mass	0.1	0.3	2.8	-0.0	0.2	0.4	-1.7	0.2	-0.1	0.2	0.3	0.2	-0.5	0.1	0.1	-0.5
Osteoarthritis (self-reported)	0.1	0.1	0.3	-0.4	-0.0	-0.5	-0.3	-0.2	-0.5	-0.3	-0.2	-0.1	-0.3	-0.3	-0.3	-0.4
Smoking status: Current	0.1	0.2	0.7	-0.2	-0.8	-0.4	0.7	-0.2	-0.3	-0.0	-0.2	0.3	-0.7	-0.1	-0.1	-0.5
Medication: Atorvastatin	0.1	0.1	1.2	0.5	-0.3	0.0	1.1	0.2	0.1	0.1	0.2	0.3	0.1	0.2	0.2	0.2
Unable to work because of sickness or disability	0.1	0.1	0.7	-0.5	-0.9	-0.4	0.4	0.0	-0.1	-0.1	0.0	-0.2	-0.2	-0.1	-0.1	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	0.2	-0.3	0.6	0.2	0.0	-0.0	0.1	0.0	0.1	-0.7	-0.0	-0.1	-0.5
Pain experienced in last month	0.1	0.2	1.0	-0.2	0.2	-0.2	-1.0	-0.2	-0.3	-0.5	-0.3	-0.9	0.2	-0.5	-0.5	-0.2
Supplements: Calcium	0.1	0.2	0.7	0.3	-0.7	-0.0	-0.5	-0.1	-0.0	-0.4	-0.0	-0.8	0.1	-0.4	-0.4	-0.1
Depressed Affect (Nagel 2018)	0.0	0.1	0.5	0.3	-0.4	0.3	0.7	-0.2	0.1	0.1	-0.2	0.1	-0.4	-0.0	-0.0	-0.2
Depression (Nagel 2018)	0.0	0.1	0.2	-0.1	-0.4	-0.0	0.4	-0.3	0.2	0.0	-0.3	-0.3	0.1	-0.1	-0.1	0.1
Crohns Disease (2017)	0.0	0.1	0.3	-0.1	-0.1	-0.0	-0.0	-0.4	0.1	-0.1	-0.3	-0.5	-0.3	-0.4	-0.4	-0.3
Reaction Time	0.0	0.0	0.2	-0.2	-0.1	-0.2	-0.2	-0.3	0.1	0.0	-0.2	-0.1	-0.4	-0.1	-0.1	-0.3
Body Mass Index (BMI) (2010)	0.0	0.0	0.2	0.2	0.5	0.1	-0.4	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.1	0.3	0.3	0.3	-0.1	0.5	0.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Fasting Glucose	0.0	0.0	0.3	-0.1	-0.2	0.2	0.5	-0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.2	-0.2	0.4	-0.4	0.2	-0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Lung FEV1/FVC ratio	0.0	0.1	0.4	-0.1	0.2	-0.6	-0.1	-0.4	-0.1	-0.2	-0.4	-0.3	-0.1	-0.3	-0.3	-0.1
Tanning	0.0	0.3	2.4	-0.2	1.6	-0.5	-0.9	-0.2	-0.2	-0.2	-0.2	-0.3	0.0	-0.2	-0.2	-0.1
Sensitivity / hurt feelings	0.0	0.1	0.3	0.6	0.0	0.3	0.4	-0.1	-0.0	-0.2	-0.1	-0.3	0.3	-0.2	-0.1	0.2
Relative age voice broke	0.0	0.0	0.2	0.0	0.4	-0.3	0.4	-0.0	0.2	0.1	0.0	0.2	-0.3	0.0	0.0	-0.1
Medication: Ramipril	0.0	0.1	0.2	0.0	-0.2	-0.0	0.4	-0.1	-0.3	-0.2	0.0	-0.4	-0.2	-0.3	-0.3	-0.3
Arm fat mass (right)	0.0	0.2	0.7	-0.3	-0.4	0.3	0.3	-0.2	-0.5	-0.3	-0.2	0.1	-0.8	-0.3	-0.3	-0.8
Worry too long after embarrassment	0.0	0.1	0.2	0.3	-0.4	-0.3	-0.4	-0.1	0.1	-0.1	-0.1	-0.5	0.5	-0.1	-0.1	0.3
Mean time to correctly identify matches	0.0	0.0	0.2	-0.2	0.5	-0.1	0.2	-0.1	0.3	0.1	-0.0	-0.1	0.1	0.0	0.0	0.2
Arm fat percentage (left)	0.0	0.2	0.3	-0.4	-0.4	0.1	0.5	-0.4	-0.5	-0.6	-0.4	-0.2	-0.4	-0.4	-0.4	-0.5
Illnesses of father: None of the above (group 1)	0.0	0.1	0.2	-0.1	-0.4	-0.1	0.1	0.2	-0.1	-0.0	0.1	-0.2	-0.4	-0.1	-0.2	-0.5
Whole body water mass	0.0	0.3	2.8	-0.0	0.1	0.4	-1.7	0.2	-0.2	0.2	0.2	0.2	-0.5	0.1	0.0	-0.5
Arm fat mass (left)	0.0	0.2	0.7	-0.3	-0.4	0.2	0.1	-0.2	-0.5	-0.3	-0.2	0.1	-0.8	-0.3	-0.3	-0.8
Basal metabolic rate	0.0	0.3	1.6	0.2	0.2	0.7	-1.3	0.4	0.1	0.4	0.4	0.4	-0.5	0.3	0.2	-0.4
Arm fat-free mass (left)	0.0	0.2	1.2	0.1	0.4	0.6	-1.1	0.3	-0.0	0.4	0.3	0.4	-0.6	0.2	0.2	-0.5
Risk taking	0.0	0.0	0.2	0.0	-0.3	-0.1	0.4	0.2	-0.2	-0.0	0.1	-0.1	0.2	0.0	-0.0	0.1
Arm predicted mass (left)	0.0	0.3	0.7	0.3	0.5	0.8	-0.7	0.6	0.1	0.5	0.5	0.6	-0.3	0.4	0.4	-0.2

Hub : Genes

TMEM57

Models

Trait associations