Best TWAS P=4.8e-16 · Best GWAS P=1.52e-14 conditioned to 0.021
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ZNF259 | 0.08 | 0.03 | enet | 6 | 0.03 | 1.2e-04 | 5.9 | -8.1 | 4.8e-16 | -0.17 | 0.02 | 0.98 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | PAFAH1B2 | 0.11 | 0.00 | lasso | 3 | 0.00 | 1.3e-01 | 5.6 | -5.9 | 3.0e-09 | -0.59 | 0.06 | 0.22 | TRUE |
| 3 | GTEx | Colon Sigmoid | PCSK7 | 0.28 | 0.09 | lasso | 8 | 0.15 | 6.5e-06 | 6.5 | -5.4 | 6.5e-08 | -0.56 | 0.82 | 0.01 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | PCSK7 | 0.20 | 0.05 | enet | 31 | 0.07 | 7.0e-05 | 3.4 | 5.8 | 6.1e-09 | 0.31 | 0.26 | 0.08 | TRUE |
| 5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZNF259 | 0.04 | 0.03 | lasso | 3 | 0.02 | 8.4e-04 | 6.6 | -7.2 | 6.9e-13 | 0.05 | 0.19 | 0.08 | FALSE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | BUD13 | 0.08 | 0.00 | blup | 76 | 0.01 | 9.2e-02 | -1.6 | -6.8 | 8.0e-12 | -0.25 | 0.02 | 0.04 | TRUE |