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chr11:60,549,966-62,605,067

Best TWAS P=1.11e-21 · Best GWAS P=1.17e-21 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Artery Tibial	TMEM258	0.08	0.05	lasso	5	0.02	1.1e-02	-9.52	-9.6	1.1e-21	0.97	0.01	0.98	TRUE
2	CommonMind	Brain Pre-frontal Cortex	FEN1	0.07	0.06	lasso	4	0.06	1.1e-07	-9.51	-9.6	1.1e-21	0.96	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FADS1	0.20	0.01	blup	51	0.07	3.2e-04	-9.59	9.5	1.7e-21	-0.85	0.01	0.95	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FADS1	0.14	0.16	lasso	2	0.16	7.2e-19	-9.50	9.5	1.8e-21	-0.96	0.01	0.99	FALSE
7	GTEx	Brain Cerebellum	FADS1	0.35	0.24	enet	16	0.30	2.1e-09	-9.13	9.5	1.8e-21	-0.90	0.02	0.98	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	FADS1	0.08	0.08	enet	10	0.09	1.5e-11	-9.40	9.5	3.1e-21	-0.95	0.02	0.98	FALSE
39	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FADS2	0.02	0.01	blup	71	0.02	1.9e-03	-9.56	-9.4	4.5e-21	0.90	0.02	0.83	FALSE
19	GTEx	Pancreas	FADS1	0.17	0.13	lasso	6	0.12	1.2e-05	-9.16	9.4	5.9e-21	-0.91	0.03	0.97	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf10	0.02	0.02	blup	44	0.02	1.8e-03	-8.67	-9.3	9.6e-21	0.95	0.02	0.72	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	TMEM258	0.14	0.16	lasso	4	0.15	4.7e-19	-9.09	-9.3	9.9e-21	0.92	0.06	0.94	FALSE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	FADS1	0.05	0.05	blup	53	0.04	6.8e-05	-8.53	9.3	9.9e-21	-0.86	0.04	0.96	FALSE
8	GTEx	Brain Cerebellum	FADS3	0.26	0.18	lasso	4	0.14	5.7e-05	-9.16	9.3	1.4e-20	-0.91	0.03	0.84	FALSE
25	NTR	Blood	C11orf10	0.06	0.08	bslmm	399	0.08	1.3e-24	-9.09	-9.1	7.0e-20	0.91	0.06	0.94	FALSE
17	GTEx	Muscle Skeletal	FADS2	0.08	0.04	lasso	2	0.03	5.9e-04	-9.56	-8.9	3.7e-19	0.94	0.01	0.99	FALSE
9	GTEx	Brain Putamen basal ganglia	FADS1	0.29	0.21	enet	30	0.16	1.4e-04	-9.50	8.7	3.0e-18	-0.78	0.02	0.92	FALSE
5	GTEx	Artery Tibial	FADS2	0.08	0.02	lasso	4	0.02	6.9e-03	-9.09	-8.7	4.2e-18	0.79	0.02	0.96	FALSE
31	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FADS1	0.06	0.03	lasso	4	0.04	7.4e-03	-9.16	8.6	8.4e-18	-0.81	0.02	0.70	FALSE
14	GTEx	Esophagus Mucosa	FADS1	0.11	0.00	lasso	4	0.02	1.9e-02	-9.37	8.1	7.4e-16	-0.85	0.02	0.93	FALSE
10	GTEx	Breast Mammary Tissue (Female)	TMEM258	0.20	0.02	lasso	7	0.00	2.3e-01	-6.88	-8.0	1.1e-15	0.78	0.04	0.51	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf10	0.02	0.01	enet	11	0.01	1.6e-02	-9.09	-7.7	1.9e-14	0.77	0.01	0.78	FALSE
12	GTEx	Cells Transformed fibroblasts	TMEM258	0.15	0.05	enet	15	0.07	1.1e-05	-9.09	-7.6	3.8e-14	0.77	0.04	0.95	FALSE
29	YFS	Blood	FADS1	0.11	0.08	lasso	8	0.09	6.1e-29	-5.08	-7.4	1.4e-13	0.76	1.00	0.00	FALSE
35	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FADS2	0.33	0.27	lasso	9	0.35	9.3e-21	-5.08	-7.2	4.7e-13	0.78	0.56	0.44	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS1	0.06	0.04	blup	53	0.03	2.0e-04	-9.13	7.1	9.2e-13	-0.68	0.06	0.55	FALSE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	FADS2	0.30	0.21	lasso	2	0.22	6.7e-13	-5.08	-7.0	3.0e-12	0.75	0.64	0.36	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FADS2	0.05	0.04	lasso	3	0.05	1.9e-06	-5.08	-6.8	7.5e-12	0.70	0.21	0.75	FALSE
13	GTEx	Colon Transverse	FADS2	0.18	0.11	lasso	7	0.16	8.1e-08	-5.08	-6.8	8.8e-12	0.75	0.07	0.93	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	FADS1	0.04	0.00	blup	53	0.01	1.4e-03	-1.12	6.7	2.1e-11	-0.62	0.02	0.38	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FADS2	0.26	0.29	enet	15	0.29	2.9e-33	-5.08	-6.7	2.1e-11	0.72	1.00	0.00	FALSE
16	GTEx	Heart Left Ventricle	FADS2	0.17	0.12	enet	3	0.13	1.5e-07	-6.24	-6.7	2.8e-11	0.72	0.25	0.75	FALSE
21	GTEx	Spleen	FADS2	0.30	0.27	lasso	3	0.27	1.6e-07	-5.08	-6.5	8.1e-11	0.71	0.08	0.91	FALSE
15	GTEx	Esophagus Muscularis	FADS2	0.32	0.30	lasso	6	0.31	3.7e-19	-5.08	-6.5	8.2e-11	0.70	0.99	0.01	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS2	0.07	0.07	lasso	4	0.06	1.9e-06	-5.08	-6.5	9.7e-11	0.69	0.12	0.86	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	FADS2	0.30	0.33	lasso	8	0.33	5.6e-33	-5.08	-6.5	9.8e-11	0.71	1.00	0.00	FALSE
23	GTEx	Uterus	PPP1R32	0.66	-0.01	lasso	13	0.14	8.8e-04	0.21	-6.3	2.3e-10	0.58	0.03	0.47	FALSE
44	The Cancer Genome Atlas	Stomach Adenocarcinoma	FADS2	0.15	0.05	blup	71	0.11	2.5e-08	-5.08	-6.2	5.7e-10	0.71	0.04	0.96	FALSE
4	GTEx	Artery Aorta	FADS2	0.18	0.17	lasso	3	0.14	3.2e-08	-5.08	-6.1	9.5e-10	0.69	0.23	0.76	FALSE
43	The Cancer Genome Atlas	Rectum Adenocarcinoma	FADS2	0.47	0.34	lasso	5	0.30	7.9e-08	-5.08	-6.1	1.4e-09	0.68	0.03	0.95	FALSE
3	GTEx	Adrenal Gland	INCENP	0.23	0.05	lasso	3	0.03	3.8e-02	4.96	5.7	1.2e-08	-0.43	0.08	0.08	FALSE
20	GTEx	Spleen	MYRF	0.23	0.00	lasso	4	-0.01	4.6e-01	-6.58	-5.6	1.8e-08	0.52	0.04	0.37	FALSE
26	NTR	Blood	FADS2	0.30	0.33	lasso	7	0.33	9.0e-109	-5.08	-5.6	2.0e-08	0.63	1.00	0.00	FALSE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	FADS2	0.04	0.04	lasso	4	0.02	1.7e-03	-5.08	-5.4	5.3e-08	0.62	0.06	0.78	FALSE
24	GTEx	Whole Blood	FADS2	0.49	0.48	lasso	5	0.48	3.0e-49	-5.08	-5.3	1.1e-07	0.60	1.00	0.00	FALSE
11	GTEx	Cells Transformed fibroblasts	FADS2	0.20	0.23	lasso	3	0.23	4.6e-17	-5.08	-5.3	1.4e-07	0.60	1.00	0.00	FALSE
18	GTEx	Nerve Tibial	FADS2	0.20	0.14	lasso	3	0.13	1.5e-09	-5.08	-5.2	1.7e-07	0.60	0.85	0.15	FALSE
22	GTEx	Thyroid	FADS2	0.16	0.18	lasso	4	0.17	7.0e-13	-5.08	-5.1	3.1e-07	0.59	1.00	0.00	FALSE