Best TWAS P=5.02e-20 · Best GWAS P=6.69e-22 conditioned to 0.0029
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Hippocampus | DDX49 | 0.23 | -0.01 | lasso | 4 | -0.01 | 6.6e-01 | -5.4 | 5.5 | 3.2e-08 | -0.61 | 0.02 | 0.57 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | ATP13A1 | 0.14 | 0.06 | lasso | 5 | 0.05 | 2.2e-04 | -9.4 | -9.2 | 5.0e-20 | 0.93 | 0.03 | 0.94 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | GATAD2A | 0.07 | 0.00 | lasso | 4 | 0.00 | 8.1e-01 | -3.4 | -6.8 | 9.3e-12 | 0.72 | 0.06 | 0.35 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | MEF2B | 0.08 | 0.08 | enet | 15 | 0.09 | 1.7e-07 | -5.5 | 5.7 | 1.1e-08 | -0.48 | 0.84 | 0.03 | FALSE |
| 5 | GTEx | Esophagus Mucosa | MEF2B | 0.09 | 0.10 | enet | 10 | 0.09 | 1.2e-06 | -5.5 | 5.3 | 1.4e-07 | -0.50 | 0.86 | 0.03 | FALSE |
| 6 | GTEx | Esophagus Muscularis | MEF2B | 0.09 | 0.10 | lasso | 2 | 0.10 | 1.4e-06 | -5.5 | 5.2 | 2.6e-07 | -0.50 | 0.85 | 0.04 | FALSE |
| 7 | GTEx | Nerve Tibial | MEF2B | 0.13 | 0.10 | lasso | 3 | 0.08 | 2.0e-06 | -5.5 | 6.7 | 2.3e-11 | -0.64 | 0.16 | 0.82 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | MEF2B | 0.19 | 0.13 | lasso | 5 | 0.11 | 2.3e-09 | -5.4 | 5.1 | 2.8e-07 | -0.52 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Thyroid | MEF2B | 0.15 | 0.16 | lasso | 1 | 0.16 | 5.1e-12 | -5.5 | 5.5 | 4.8e-08 | -0.53 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Whole Blood | GATAD2A | 0.06 | 0.02 | lasso | 9 | 0.03 | 1.7e-03 | -3.3 | -6.0 | 2.6e-09 | 0.63 | 0.35 | 0.54 | FALSE |
| 11 | GTEx | Whole Blood | MEF2B | 0.12 | 0.09 | enet | 9 | 0.11 | 1.5e-10 | -5.5 | 5.8 | 5.4e-09 | -0.49 | 1.00 | 0.00 | FALSE |
| 12 | METSIM | Adipose | GMIP | 0.07 | 0.03 | lasso | 4 | 0.03 | 7.8e-05 | 3.7 | -5.2 | 2.6e-07 | 0.45 | 0.48 | 0.09 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | ATP13A1 | 0.10 | 0.07 | lasso | 5 | 0.06 | 1.3e-08 | -7.3 | 7.9 | 3.7e-15 | -0.78 | 0.16 | 0.84 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MEF2B | 0.05 | 0.01 | blup | 61 | 0.03 | 3.2e-06 | -5.4 | 6.0 | 2.7e-09 | -0.50 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TM6SF2 | 0.04 | 0.03 | blup | 35 | 0.03 | 2.5e-04 | -3.4 | -6.4 | 1.7e-10 | 0.76 | 0.22 | 0.44 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC729991-MEF2B | 0.05 | 0.02 | blup | 66 | 0.01 | 2.1e-02 | -5.4 | -5.8 | 8.1e-09 | 0.56 | 0.00 | 0.91 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | TM6SF2 | 0.05 | 0.04 | blup | 34 | 0.05 | 2.8e-05 | -3.4 | -6.0 | 2.6e-09 | 0.71 | 0.29 | 0.55 | FALSE |