[Hub]/) : Traits : LDL Cholesterol : ← →

chr19:18,333,894-20,451,172

Best TWAS P=5.02e-20 · Best GWAS P=6.69e-22 conditioned to 0.0029

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Cells Transformed fibroblasts	ATP13A1	0.14	0.06	lasso	5	0.05	2.2e-04	-9.4	-9.2	5.0e-20	0.93	0.03	0.94	TRUE
13	ROSMAP	Brain Pre-frontal Cortex	ATP13A1	0.10	0.07	lasso	5	0.06	1.3e-08	-7.3	7.9	3.7e-15	-0.78	0.16	0.84	FALSE
3	GTEx	Cells Transformed fibroblasts	GATAD2A	0.07	0.00	lasso	4	0.00	8.1e-01	-3.4	-6.8	9.3e-12	0.72	0.06	0.35	FALSE
7	GTEx	Nerve Tibial	MEF2B	0.13	0.10	lasso	3	0.08	2.0e-06	-5.5	6.7	2.3e-11	-0.64	0.16	0.82	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TM6SF2	0.04	0.03	blup	35	0.03	2.5e-04	-3.4	-6.4	1.7e-10	0.76	0.22	0.44	FALSE
10	GTEx	Whole Blood	GATAD2A	0.06	0.02	lasso	9	0.03	1.7e-03	-3.3	-6.0	2.6e-09	0.63	0.35	0.54	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	TM6SF2	0.05	0.04	blup	34	0.05	2.8e-05	-3.4	-6.0	2.6e-09	0.71	0.29	0.55	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	MEF2B	0.05	0.01	blup	61	0.03	3.2e-06	-5.4	6.0	2.7e-09	-0.50	0.01	0.99	FALSE
11	GTEx	Whole Blood	MEF2B	0.12	0.09	enet	9	0.11	1.5e-10	-5.5	5.8	5.4e-09	-0.49	1.00	0.00	FALSE
16	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC729991-MEF2B	0.05	0.02	blup	66	0.01	2.1e-02	-5.4	-5.8	8.1e-09	0.56	0.00	0.91	FALSE
4	GTEx	Cells Transformed fibroblasts	MEF2B	0.08	0.08	enet	15	0.09	1.7e-07	-5.5	5.7	1.1e-08	-0.48	0.84	0.03	FALSE
1	GTEx	Brain Hippocampus	DDX49	0.23	-0.01	lasso	4	-0.01	6.6e-01	-5.4	5.5	3.2e-08	-0.61	0.02	0.57	FALSE
9	GTEx	Thyroid	MEF2B	0.15	0.16	lasso	1	0.16	5.1e-12	-5.5	5.5	4.8e-08	-0.53	1.00	0.00	FALSE
5	GTEx	Esophagus Mucosa	MEF2B	0.09	0.10	enet	10	0.09	1.2e-06	-5.5	5.3	1.4e-07	-0.50	0.86	0.03	FALSE
6	GTEx	Esophagus Muscularis	MEF2B	0.09	0.10	lasso	2	0.10	1.4e-06	-5.5	5.2	2.6e-07	-0.50	0.85	0.04	FALSE
12	METSIM	Adipose	GMIP	0.07	0.03	lasso	4	0.03	7.8e-05	3.7	-5.2	2.6e-07	0.45	0.48	0.09	FALSE
8	GTEx	Skin Sun Exposed Lower leg	MEF2B	0.19	0.13	lasso	5	0.11	2.3e-09	-5.4	5.1	2.8e-07	-0.52	1.00	0.00	FALSE