[Hub]/) : Traits : LDL Cholesterol : ← →

chr19:44,190,626-46,547,330

Best TWAS P=1.2e-84 · Best GWAS P=8.72e-147 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PVR	0.22	0.17	enet	26	0.17	2.3e-20	-8.17	-6.0	2.1e-09	-0.04	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	CEACAM19	0.13	0.11	enet	9	0.12	4.6e-10	4.88	5.9	3.5e-09	0.04	0.99	0.00	TRUE
3	GTEx	Adipose Visceral Omentum	ZNF285	0.17	0.05	enet	20	0.07	1.3e-04	-0.77	-7.3	2.2e-13	-0.17	0.39	0.15	TRUE
4	GTEx	Artery Aorta	CTB-179K24.3	0.17	0.05	lasso	3	0.06	1.9e-04	-8.02	7.4	9.7e-14	0.02	0.29	0.03	TRUE
5	GTEx	Artery Tibial	CEACAM19	0.26	0.14	lasso	12	0.20	2.7e-15	4.88	8.0	1.7e-15	0.01	1.00	0.00	FALSE
6	GTEx	Cells Transformed fibroblasts	PVR	0.27	0.09	lasso	8	0.12	1.2e-09	-7.24	-5.3	1.2e-07	-0.02	1.00	0.00	TRUE
7	GTEx	Esophagus Mucosa	PVRL2	0.15	0.01	enet	10	0.02	1.7e-02	-20.10	16.2	5.4e-59	-0.07	0.14	0.04	FALSE
8	GTEx	Esophagus Muscularis	CEACAM19	0.19	0.06	lasso	5	0.08	8.6e-06	4.88	7.8	5.9e-15	-0.02	0.54	0.02	TRUE
9	GTEx	Skin Not Sun Exposed Suprapubic	ZNF229	0.28	0.09	enet	58	0.08	2.2e-05	3.59	-7.5	4.5e-14	-0.27	0.19	0.06	TRUE
10	GTEx	Skin Sun Exposed Lower leg	PVR	0.11	0.05	lasso	2	0.06	2.1e-05	-8.10	-6.6	3.5e-11	-0.04	0.84	0.01	FALSE
11	GTEx	Stomach	BCAM	0.33	0.00	enet	3	0.01	9.6e-02	1.82	-13.1	5.4e-39	-0.05	0.07	0.08	TRUE
12	GTEx	Thyroid	CEACAM19	0.34	0.28	enet	26	0.30	9.9e-24	4.88	6.8	8.5e-12	0.09	1.00	0.00	FALSE
13	METSIM	Adipose	BLOC1S3	0.08	0.06	enet	26	0.07	8.6e-11	0.35	-5.5	3.7e-08	0.00	1.00	0.00	TRUE
14	METSIM	Adipose	CEACAM19	0.24	0.07	enet	29	0.12	7.7e-18	-3.97	7.2	5.4e-13	0.06	1.00	0.00	TRUE
15	METSIM	Adipose	GEMIN7	0.08	0.03	enet	13	0.05	1.6e-08	4.07	5.8	8.0e-09	-0.01	0.96	0.00	FALSE
16	NTR	Blood	KLC3	0.02	0.00	blup	367	0.00	2.6e-02	-0.67	-5.8	6.6e-09	-0.15	0.31	0.02	TRUE
17	NTR	Blood	PVRL2	0.24	0.25	lasso	2	0.28	8.4e-92	8.90	7.9	2.5e-15	-0.09	1.00	0.00	TRUE
18	YFS	Blood	TOMM40	0.04	0.00	bslmm	371	0.01	2.6e-04	-11.90	12.1	8.3e-34	0.02	0.05	0.02	TRUE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	GEMIN7	0.03	0.02	blup	42	0.02	5.8e-06	4.23	7.0	1.9e-12	0.13	0.02	0.90	FALSE
20	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	GEMIN7	0.20	0.06	blup	42	0.08	1.0e-04	4.23	6.5	7.9e-11	0.03	0.01	0.97	TRUE
21	The Cancer Genome Atlas	Glioblastoma Multiforme	GEMIN7	0.24	0.05	lasso	3	0.13	9.6e-05	4.69	5.7	1.3e-08	0.25	0.02	0.14	TRUE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CEACAM16	0.04	0.00	enet	6	0.02	1.4e-03	-10.40	6.5	9.7e-11	0.15	0.03	0.03	TRUE
23	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GEMIN7	0.07	0.04	enet	8	0.04	6.4e-05	-7.83	7.1	1.6e-12	0.02	0.00	0.99	TRUE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GEMIN7	0.03	0.01	enet	9	0.02	8.1e-04	4.23	7.0	2.0e-12	0.08	0.01	0.77	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PVR	0.08	0.10	lasso	4	0.09	9.8e-11	-7.19	-7.0	3.6e-12	-0.05	1.00	0.00	TRUE
26	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GEMIN7	0.14	0.02	blup	42	0.08	1.8e-05	3.15	7.3	3.2e-13	0.14	0.01	0.86	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	GEMIN7	0.36	0.16	enet	19	0.20	2.4e-22	4.23	8.6	1.2e-17	0.07	0.98	0.02	TRUE
28	The Cancer Genome Atlas	Lung Adenocarcinoma	APOC1	0.06	0.05	enet	8	0.06	4.6e-07	1.79	-5.4	6.5e-08	-0.11	0.76	0.01	TRUE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	NKPD1	0.03	0.00	blup	37	0.01	4.5e-02	4.12	-6.7	2.0e-11	-0.17	0.02	0.47	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	PVR	0.03	0.02	blup	51	0.02	1.4e-03	-7.63	-6.3	3.0e-10	-0.01	0.08	0.04	FALSE
31	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	APOC1	0.05	0.00	blup	47	0.01	4.3e-02	1.91	5.8	5.8e-09	-0.32	0.01	0.06	TRUE
32	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	APOE	0.06	0.00	blup	49	0.01	4.5e-02	1.91	9.2	2.6e-20	-0.29	0.02	0.12	TRUE
33	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GEMIN7	0.06	0.01	blup	42	0.02	3.5e-03	4.23	6.0	2.5e-09	0.12	0.01	0.77	FALSE
34	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	APOC2	0.18	0.12	enet	14	0.13	5.2e-06	-2.79	9.2	4.9e-20	0.19	0.65	0.03	FALSE
35	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	GEMIN7	0.11	-0.01	lasso	5	0.00	2.3e-01	-4.33	5.2	2.2e-07	0.06	0.01	0.20	TRUE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	CEACAM19	0.15	0.08	lasso	3	0.07	4.0e-08	4.88	5.2	2.6e-07	0.03	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Stomach Adenocarcinoma	GEMIN7	0.12	0.00	blup	42	0.03	3.7e-03	4.23	5.6	1.9e-08	0.13	0.01	0.76	FALSE
38	The Cancer Genome Atlas	Stomach Adenocarcinoma	PVR	0.04	0.00	blup	50	0.02	8.6e-03	-7.77	-5.2	2.6e-07	-0.05	0.03	0.10	FALSE
39	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CEACAM19	0.17	0.11	enet	7	0.14	1.3e-05	4.88	5.4	7.1e-08	0.06	0.10	0.06	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	GEMIN7	0.32	0.10	enet	18	0.16	2.5e-15	4.23	6.1	1.2e-09	0.11	0.06	0.94	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	PVRL2	0.09	0.05	blup	55	0.03	4.6e-04	8.42	-19.5	1.2e-84	-0.05	0.46	0.09	TRUE