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chr11:198,510-1,423,176

Best TWAS P=1.58e-12 · Best GWAS P=3.5e-11 conditioned to 0.0237

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Adipose Subcutaneous	HRAS	0.15	0.06	enet	36	0.07	4.1e-06	-6.1	7.1	1.6e-12	-0.55	0.04	0.95	TRUE
29	GTEx	Whole Blood	TMEM80	0.26	0.12	enet	47	0.16	6.1e-15	-2.5	-5.8	4.9e-09	0.45	0.93	0.07	TRUE
9	GTEx	Brain Putamen basal ganglia	RP11-496I9.1	0.26	0.00	lasso	7	0.04	3.2e-02	-5.7	-6.8	9.1e-12	0.68	0.07	0.50	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	IRF7	0.07	0.10	lasso	5	0.09	3.5e-09	-6.5	-6.5	5.9e-11	0.91	0.01	0.99	FALSE
5	GTEx	Artery Tibial	HRAS	0.19	0.10	lasso	6	0.09	9.4e-08	-5.7	6.4	1.3e-10	-0.61	0.09	0.91	FALSE
51	The Cancer Genome Atlas	Soft Tissue Sarcoma	C11orf35	0.04	0.02	blup	41	0.03	7.6e-03	-6.2	-6.3	2.2e-10	0.74	0.01	0.69	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	HRAS	0.02	0.00	blup	41	0.01	2.8e-02	-5.7	6.3	3.7e-10	-0.59	0.02	0.68	FALSE
12	GTEx	Esophagus Mucosa	DRD4	0.09	0.02	lasso	5	0.05	1.7e-04	-6.6	6.1	7.8e-10	-0.72	0.01	0.97	FALSE
19	GTEx	Nerve Tibial	HRAS	0.16	0.10	enet	10	0.11	2.1e-08	-5.7	6.0	1.7e-09	-0.60	0.55	0.44	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	CDHR5	0.03	0.02	lasso	2	0.01	4.1e-02	-5.7	5.9	2.8e-09	-0.74	0.05	0.67	FALSE
28	GTEx	Thyroid	IRF7	0.10	0.01	lasso	4	0.00	2.3e-01	-4.5	-5.9	3.8e-09	0.74	0.02	0.84	FALSE
14	GTEx	Esophagus Muscularis	HRAS	0.12	0.14	lasso	4	0.13	1.7e-08	-5.7	5.9	3.9e-09	-0.51	0.47	0.52	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	TMEM80	0.31	0.18	lasso	5	0.27	3.8e-15	5.3	-5.8	5.9e-09	0.42	0.91	0.09	FALSE
4	GTEx	Artery Aorta	TMEM80	0.44	0.33	lasso	11	0.37	2.6e-21	5.0	-5.7	1.0e-08	0.47	0.97	0.03	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HRAS	0.03	0.00	blup	41	0.02	4.9e-03	-5.6	5.7	1.0e-08	-0.45	0.02	0.67	FALSE
40	The Cancer Genome Atlas	Glioblastoma Multiforme	CDHR5	0.15	0.01	blup	44	0.02	9.6e-02	-2.8	5.7	1.2e-08	-0.59	0.01	0.19	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM80	0.26	0.33	enet	11	0.38	1.2e-41	5.3	-5.7	1.2e-08	0.41	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	IRF7	0.10	0.05	blup	46	0.07	7.6e-09	-6.6	-5.7	1.3e-08	0.68	0.01	0.99	FALSE
16	GTEx	Lung	HRAS	0.11	0.04	enet	8	0.07	5.7e-06	-2.7	5.7	1.4e-08	-0.58	0.24	0.73	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM80	0.33	0.32	enet	12	0.38	1.6e-45	5.3	-5.7	1.4e-08	0.37	0.00	1.00	FALSE
23	GTEx	Pituitary	HRAS	0.18	0.05	lasso	3	0.01	1.9e-01	-6.1	5.7	1.5e-08	-0.76	0.04	0.61	FALSE
3	GTEx	Artery Aorta	HRAS	0.22	0.20	lasso	4	0.18	4.0e-10	-5.7	5.6	2.0e-08	-0.45	0.54	0.46	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	DRD4	0.03	0.01	blup	48	0.01	9.0e-04	-6.3	-5.6	2.3e-08	0.40	0.03	0.50	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TMEM80	0.39	0.33	enet	43	0.36	1.6e-46	5.3	-5.6	2.4e-08	0.41	0.89	0.11	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	TMEM80	0.56	0.30	lasso	7	0.27	3.8e-10	5.0	-5.6	2.4e-08	0.39	0.94	0.06	FALSE
17	GTEx	Muscle Skeletal	HRAS	0.09	0.05	enet	14	0.04	3.2e-05	-5.7	5.6	2.6e-08	-0.70	0.02	0.97	FALSE
53	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM80	0.09	0.03	blup	49	0.04	8.4e-04	5.0	-5.6	2.8e-08	0.37	0.00	0.94	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	IRF7	0.03	0.03	blup	46	0.03	9.9e-07	-6.6	-5.5	3.3e-08	0.77	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	HRAS	0.07	0.01	blup	41	0.04	4.2e-03	-2.6	5.5	3.5e-08	-0.59	0.02	0.71	FALSE
22	GTEx	Pancreas	DEAF1	0.19	0.20	enet	8	0.07	8.4e-04	-4.7	-5.5	4.3e-08	0.53	0.77	0.18	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	TMEM80	0.52	0.51	enet	24	0.56	1.2e-86	5.3	-5.5	4.5e-08	0.41	0.90	0.10	FALSE
47	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM80	0.13	0.08	blup	49	0.11	7.8e-13	4.9	-5.5	4.8e-08	0.38	0.00	1.00	FALSE
13	GTEx	Esophagus Mucosa	HRAS	0.13	0.10	enet	6	0.07	1.8e-05	-5.7	5.5	4.9e-08	-0.70	0.09	0.90	FALSE
27	GTEx	Thyroid	TMEM80	0.46	0.39	enet	30	0.40	2.0e-32	-4.7	-5.4	5.2e-08	0.48	0.99	0.01	FALSE
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM80	0.11	0.06	blup	49	0.08	1.7e-09	5.0	-5.4	6.4e-08	0.37	0.00	1.00	FALSE
44	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM80	0.15	0.21	enet	10	0.20	1.3e-11	5.0	-5.4	6.7e-08	0.40	0.00	1.00	FALSE
20	GTEx	Ovary	HRAS	0.29	0.10	enet	13	0.05	1.9e-02	-6.2	5.4	8.7e-08	-0.46	0.06	0.28	FALSE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM80	0.17	0.12	enet	17	0.16	1.2e-09	5.0	-5.3	9.0e-08	0.44	0.00	1.00	FALSE
15	GTEx	Esophagus Muscularis	TMEM80	0.68	0.42	enet	71	0.48	1.4e-32	5.0	-5.3	9.3e-08	0.39	0.97	0.03	FALSE
21	GTEx	Ovary	TMEM80	0.43	0.27	enet	20	0.16	8.1e-05	5.0	-5.3	9.6e-08	0.47	0.17	0.44	FALSE
48	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TMEM80	0.35	0.17	lasso	3	0.17	2.5e-11	5.3	-5.3	1.1e-07	0.36	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM80	0.23	0.20	blup	49	0.21	7.0e-43	5.3	-5.3	1.2e-07	0.37	0.00	1.00	FALSE
26	GTEx	Testis	TMEM80	0.64	0.37	lasso	7	0.43	1.2e-20	5.0	-5.3	1.3e-07	0.39	0.97	0.03	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	EPS8L2	0.05	0.05	lasso	2	0.03	3.7e-04	5.3	5.3	1.3e-07	-0.34	0.00	0.99	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	HRAS	0.24	0.19	lasso	7	0.27	1.4e-34	-3.0	5.3	1.4e-07	-0.48	0.84	0.16	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM80	0.40	0.49	lasso	8	0.49	2.9e-54	5.0	-5.3	1.4e-07	0.38	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TMEM80	0.13	0.12	enet	16	0.12	6.0e-10	5.3	-5.2	1.8e-07	0.33	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Stomach Adenocarcinoma	PTDSS2	0.05	0.05	lasso	4	0.06	4.6e-05	-5.6	5.2	1.8e-07	-0.50	0.01	0.97	FALSE
30	METSIM	Adipose	TMEM80	0.37	0.20	enet	23	0.30	1.3e-45	5.3	-5.2	2.0e-07	0.38	0.92	0.08	FALSE
31	NTR	Blood	TMEM80	0.01	0.01	enet	5	0.00	3.9e-02	5.0	-5.2	2.2e-07	0.43	0.14	0.46	FALSE
8	GTEx	Brain Cerebellum	EPS8L2	0.42	0.26	enet	15	0.37	5.3e-12	-2.5	-5.2	2.3e-07	0.50	0.44	0.54	FALSE
24	GTEx	Prostate	TMEM80	0.45	0.31	enet	21	0.24	8.3e-07	5.0	-5.2	2.4e-07	0.47	0.32	0.62	FALSE
7	GTEx	Brain Cerebellum	HRAS	0.25	0.12	lasso	5	0.14	6.5e-05	-5.7	5.1	2.7e-07	-0.49	0.16	0.56	FALSE
10	GTEx	Colon Sigmoid	HRAS	0.22	0.15	lasso	5	0.16	3.4e-06	-4.5	5.1	2.7e-07	-0.52	0.41	0.47	FALSE
50	The Cancer Genome Atlas	Rectum Adenocarcinoma	TMEM80	0.34	0.13	blup	49	0.08	6.6e-03	5.0	-5.1	2.8e-07	0.40	0.00	0.77	FALSE
6	GTEx	Brain Caudate basal ganglia	RP11-496I9.1	0.37	0.07	lasso	7	0.03	3.6e-02	-5.7	-5.1	2.9e-07	0.68	0.06	0.56	FALSE
18	GTEx	Muscle Skeletal	TMEM80	0.40	0.25	lasso	8	0.26	6.1e-26	5.0	-5.1	3.1e-07	0.39	0.97	0.03	FALSE