Hub : Genes

DEAF1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0870	0.0280	2.8e-05	0.042	0.054	0.046	0.064	0.049	6.3e-06	3.7e-07	2.8e-06	3.3e-08	1.1e-06
2	GTEx	Adrenal Gland	0.1971	0.0852	8.1e-03	0.164	NA	0.122	NA	0.138	1.7e-06	NA	3.8e-05	NA	1.2e-05
3	GTEx	Muscle Skeletal	0.0982	0.0327	2.8e-04	0.014	NA	0.003	NA	0.003	1.4e-02	NA	1.5e-01	NA	1.5e-01
4	GTEx	Pancreas	0.1920	0.0670	6.8e-04	0.199	NA	0.067	NA	0.043	8.1e-09	NA	8.4e-04	NA	6.8e-03
5	ROSMAP	Brain Pre-frontal Cortex	0.0863	0.0318	2.5e-03	0.033	0.017	0.018	0.022	0.015	3.9e-05	2.3e-03	2.0e-03	6.1e-04	3.9e-03
6	YFS	Blood	0.0119	0.0066	2.2e-02	-0.001	0.002	-0.001	0.001	-0.001	8.8e-01	6.3e-02	6.9e-01	1.1e-01	8.5e-01
7	TCGA	Breast Invasive Carcinoma	0.0242	0.0134	4.3e-03	0.018	0.003	0.001	NA	0.010	1.2e-04	6.1e-02	1.9e-01	NA	2.7e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.8	1.2	3.1	0.1	-1.6	-0.9	1.8	-0.2	0.3	1.5
Bipolar Disorder or Schizophrenia	0.3	0.6	1.4	-1.0	0.5	1.0	-0.6	0.5	-1.2	-0.6
Depressed Affect (Nagel 2018)	0.2	0.5	0.9	-0.8	0.5	1.0	-0.6	-0.6	-0.9	-0.6
Depression (Nagel 2018)	0.3	0.4	0.9	-0.5	0.5	0.5	-0.7	-0.5	-1.0	-0.6
Intelligence (Savage-Jansen 2018)	1.7	5.2	14.5	-3.8	2.0	1.4	-2.0	-1.2	-2.6	-2.1
Neuroticism (Nagel 2018)	0.2	0.4	1.5	-0.6	-0.2	0.4	0.2	-1.2	-0.5	0.3
Schizophrenia (2018)	1.5	3.1	4.7	-1.2	1.9	1.9	-2.1	0.9	-2.2	-1.9
Schizophrenia vs Biploar Disorder	0.1	0.1	0.6	0.0	0.0	0.0	0.0	0.0	-0.3	-0.7
Worry (Nagel 2018)	0.7	1.4	3.5	0.7	-1.7	0.2	1.6	0.4	-0.2	1.9
Alzheimer’s Disease (in mother)	2.8	3.3	6.2	-2.5	1.9	1.5	-1.8	-0.8	-1.8	-1.9
Alzheimer’s Disease (in father)	0.2	0.2	0.9	-0.3	-0.1	-0.3	0.4	-0.9	0.1	0.1
Alzheimer’s Disease (including proxy)	1.6	2.4	3.8	-1.3	1.9	1.2	-1.8	-1.6	-0.9	-1.9
Crohns Disease (2017)	0.9	2.0	3.1	0.9	1.8	1.1	-1.6	1.8	-0.2	-1.7
Irritable Bowel Disease (IBD)	0.6	1.4	3.1	1.6	1.2	0.4	-0.9	1.8	0.5	-1.2
Ulcerative Colitis (UC)	0.4	0.8	2.7	1.6	-0.2	-0.4	0.5	0.9	1.3	0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.8	1.5	5.5	0.8	0.2	-1.3	0.1	-2.3	1.6	-0.2
Verbal and Numeric Reasoning (VNR)	1.8	4.4	12.3	-3.5	1.7	1.3	-1.6	-0.5	-2.7	-1.8
Breast Cancer	1.7	4.2	6.4	-2.5	1.8	-0.4	-2.0	-2.3	-2.4	-2.2
Ovarian Cancer	1.4	1.9	3.2	-1.8	1.5	1.3	-1.4	0.0	-1.4	-1.5
Prostate Cancer	0.9	1.2	2.0	-0.2	1.3	-0.6	-1.1	-1.4	1.4	-1.2
Age at First Birth	0.2	0.2	0.7	-0.3	0.9	-0.0	-0.3	0.5	-0.0	-0.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.6	2.2	6.5	-1.3	2.2	0.4	-2.5	-1.4	0.6	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.9	1.5	4.6	1.3	1.2	-0.4	-0.9	2.2	0.7	-1.1
Mean Putamen Volume	1.1	1.3	4.9	2.2	0.7	0.6	-0.7	1.4	0.8	-0.3
Fasting Glucose	3.5	4.1	6.9	-1.4	2.4	2.4	-2.6	-0.7	-1.6	-2.4
HbA1C	1.1	1.2	2.0	1.3	1.0	-0.3	-1.4	-0.1	-1.4	-1.2
HDL Cholesterol	1.7	2.9	6.2	1.8	-2.3	-1.2	2.5	-1.4	1.4	0.0
LDL Cholesterol	0.4	0.7	2.3	-1.2	0.7	0.4	-0.6	0.3	-1.5	0.0
Lupus	12.2	18.5	30.0	-4.5	4.7	3.4	-5.5	-0.7	-4.6	-4.9
Neuroticism (2016)	2.2	3.1	5.9	1.6	-2.0	-1.2	2.4	1.0	1.3	2.3
Primary Biliary Cirrhosis	3.0	4.3	9.7	-3.1	1.9	1.7	-2.3	-1.7	-1.3	-1.9
Rheumatoid Arthritis	0.0	0.0	0.1	0.3	0.0	-0.1	-0.3	-0.2	0.1	0.0
Schizophrenia (2014)	0.6	1.3	2.4	-1.5	1.3	0.8	-1.3	0.3	-1.2	-1.1
Triglycerides	1.4	2.3	5.8	-2.0	1.3	0.6	-1.7	1.1	-2.4	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.7	1.0	3.2	1.8	0.4	-0.2	-0.0	0.8	1.7	-0.5
Blood Eosinophil Count	0.5	3.6	7.0	-2.6	1.7	1.4	-1.6	1.3	-2.5	-1.9
Blood Platelet Count	0.2	2.6	10.0	1.2	0.8	-0.3	-2.1	-1.1	3.2	-0.7
Blood Red Count	0.5	4.9	8.2	1.6	-2.4	-2.2	2.1	2.9	0.9	2.7
Blood White Count	0.4	2.8	7.7	-2.2	1.4	-2.8	-1.4	-0.4	0.9	-1.4
Heel T-Score	0.3	2.0	5.3	0.4	-1.4	-1.1	1.3	2.3	1.1	1.6
BMI	0.4	2.4	4.1	1.0	1.6	1.5	-2.0	-1.5	1.5	-1.6
Height	0.7	13.1	23.8	-4.9	3.5	3.3	-3.1	-0.1	-4.0	-4.4
Waist Hip Ratio (WHR)	1.5	6.6	20.4	-2.8	2.5	0.2	-2.6	0.3	-4.5	-2.2
Systolic Blood Pressure	1.0	5.1	12.9	2.5	-2.2	-0.7	2.2	1.1	3.6	2.4
Smoking Status	1.0	2.5	4.8	2.0	-1.6	-2.2	1.6	-1.3	0.5	1.3
Allergy or Eczema	0.2	0.6	2.3	-0.6	1.1	0.3	-0.3	0.0	-0.6	-1.5
Cardiovascular Disease	0.2	0.6	1.8	1.3	-0.1	1.0	-0.3	1.0	0.0	-0.1
Hypothyroidism (self reported)	3.6	8.2	14.5	-2.0	2.5	3.8	-3.5	-0.4	-3.6	-2.6
Respiratory disease	0.8	1.8	3.4	0.3	-1.5	-1.8	1.7	0.5	0.9	1.6
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.9	1.3	0.7	-0.8	-0.6	-2.0	0.3	-0.9
Lung FEV1/FVC ratio	0.5	2.4	8.1	2.9	-1.2	-1.0	1.4	0.1	1.4	1.5
Lung FVC	0.6	3.3	13.7	-3.7	0.4	1.5	-0.7	-0.3	-2.5	-0.3
Neuroticism	0.2	0.5	0.8	-0.1	-0.8	0.9	0.7	-0.7	-0.7	0.9
Chronotype (morning person)	0.4	0.8	3.2	0.4	-0.7	1.8	0.0	1.1	-0.3	0.8
Hair Pigment	0.1	2.0	3.7	-0.1	1.6	1.8	-1.9	-0.9	-1.4	-1.3
Tanning	0.1	0.8	2.8	-0.6	-0.7	-0.8	0.8	0.5	-1.7	0.4
Hand grip strength (left)	0.7	1.7	3.4	-1.7	0.9	1.9	-1.5	-0.2	-1.2	-1.2
Number of treatments/medications taken	1.3	2.3	5.4	-0.9	2.1	0.4	-2.3	-0.5	-0.4	-2.2
Average weekly spirits intake	0.5	0.6	1.3	0.3	0.9	0.2	-1.0	-1.1	-0.5	-1.0
Sensitivity / hurt feelings	0.7	1.2	3.1	-1.8	-0.6	-1.1	0.7	-1.4	-0.7	0.8
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	-0.2	0.1	0.2	-0.1	0.3	0.3	-0.3
Hearing difficulty/problems: Yes	1.2	1.9	3.3	-1.1	1.8	1.3	-1.4	0.9	-0.9	-1.8
Relative age of first facial hair	0.3	0.6	1.6	-0.5	-0.1	-1.2	0.4	0.9	-1.3	-0.1
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	2.3	0.3	1.5	0.5	-1.4	1.5	-1.2	-1.4
Ever used hormone-replacement therapy (HRT)	0.7	0.8	3.1	-0.4	0.7	1.7	-0.6	-0.0	-1.0	-0.8
Ever had hysterectomy (womb removed)	0.4	0.4	1.2	-1.1	0.1	1.1	0.2	0.7	-0.4	-0.1
Systolic blood pressure, automated reading	0.2	0.6	1.8	0.5	-0.4	1.1	0.5	0.4	1.4	0.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.7	1.3	0.5	0.2	-0.3	0.2	0.1	-0.7
Angina	0.3	0.4	1.1	-0.4	0.5	0.3	-1.0	-0.5	-0.7	-0.6
Medication for hormone replacement therapy	0.4	0.4	1.0	1.0	0.3	0.9	0.2	-1.0	0.2	-0.4
Vitamin and mineral supplements	0.3	0.4	1.3	0.9	-0.5	-1.1	0.5	-0.2	-0.3	0.4
Supplements: Zinc	0.7	0.8	2.3	0.3	-0.7	-0.4	0.9	-0.9	1.5	1.0
Medication: Co-codamol	0.4	0.5	0.9	0.1	0.6	0.8	-0.7	-0.8	0.9	-0.6
Medication: Metformin	0.2	0.2	1.0	1.0	0.2	-0.1	-0.3	-0.7	-0.1	-0.3
Diabetes (father)	0.6	0.7	1.5	-1.2	-0.7	-0.9	0.9	-1.0	-0.4	0.6
Diabetes (mother)	0.7	0.9	3.2	0.9	-0.4	1.8	0.1	1.1	-0.9	0.2
Severe depression (siblings)	0.3	0.3	0.7	-0.5	-0.6	-0.0	0.9	0.4	-0.4	0.6
Pack years adult smoking proportion	0.3	0.5	0.7	0.8	-0.6	-0.8	0.5	-0.8	0.3	0.6
Impedance of leg (right)	0.8	3.9	14.9	0.3	-0.2	0.8	0.5	3.4	-3.9	0.4
Leg fat-free mass (left)	0.6	3.1	5.6	-0.7	1.5	1.0	-1.8	-2.4	2.3	-1.9
Trunk fat percentage	0.3	1.3	2.3	-0.8	1.4	1.1	-1.5	-0.5	-0.7	-1.5
Hand grip strength (right)	0.9	2.6	6.9	-2.6	1.0	1.7	-1.7	0.2	-1.6	-1.4
Townsend deprivation index at recruitment	0.6	0.9	2.5	1.3	-0.7	-0.8	0.7	-0.3	1.6	0.6
Current tobacco smoking	1.4	2.4	4.2	2.0	-1.9	-1.2	1.9	0.1	0.7	1.8
Average weekly fortified wine intake	0.5	0.6	2.1	0.3	0.2	1.3	-0.2	1.4	0.2	-0.1
Maternal smoking around birth	0.1	0.2	0.6	0.4	-0.1	0.2	0.1	-0.8	-0.6	0.2
Fed-up feelings	0.7	1.2	3.9	-2.0	0.7	0.8	-0.7	-1.3	-0.8	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.0	-0.4	0.7	0.8	-0.9	-1.0	-0.6	-0.9
Relative age voice broke	0.3	0.5	1.3	-0.8	-0.3	-0.5	0.9	1.1	-0.5	0.4
Taking other prescription medications	1.9	3.0	6.2	-0.9	2.3	1.0	-2.5	0.6	-1.0	-2.5
Age when periods started (menarche)	0.6	1.5	5.2	-0.4	-1.0	-2.3	1.5	-0.8	0.2	1.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.8	-0.7	0.4	1.0	0.1	1.7	-1.0	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.1	-1.1	0.6	-0.6	-0.7	0.5	-0.4	-0.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.9	0.2	-0.0	0.2	-0.0	1.4	0.4	0.3
Qualifications: CSEs or equivalent	0.2	0.3	0.8	0.8	0.2	0.2	-0.5	0.1	-0.9	-0.1
Serious illness, injury or assault to yourself	1.3	1.5	2.5	-1.1	1.6	0.6	-1.5	1.4	-0.4	-1.6
High blood pressure	0.0	0.1	0.4	0.5	-0.4	0.6	-0.0	0.0	0.2	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.4	-0.2	-0.1	-0.0	0.7	0.6	-0.0	-0.3
Multivitamins +/- minerals	0.4	0.6	1.6	-1.2	-0.0	1.3	-0.2	-0.9	-0.1	0.0
Stomach or abdominal pain in last month	0.3	0.4	0.9	0.4	-0.7	0.4	0.3	0.8	-0.3	0.9
Supplements: Glucosamine	0.3	0.4	1.9	-1.4	0.1	0.4	-0.2	0.5	0.2	-0.0
Diverticular disease/diverticulitis (self-reported)	2.6	3.1	7.6	-1.9	1.4	1.9	-1.4	0.7	-2.8	-1.6
Medication: Atenolol	0.5	0.6	1.3	-0.7	0.7	0.3	-1.1	-1.0	-0.5	-0.7
Medication: Levothyroxine sodium	2.2	3.8	8.6	-1.8	1.5	2.9	-2.2	-0.5	-2.2	-1.6
Sitting height	1.2	8.3	13.3	-2.4	3.1	3.2	-3.4	-0.2	-2.8	-3.6
Chronic bronchitis/emphysema (father)	1.0	1.2	3.8	-2.0	0.6	-0.9	-0.7	-1.5	-0.7	-0.3
High blood pressure (mother)	1.6	2.2	8.9	0.1	1.4	3.0	-1.3	0.1	0.2	-1.6
Body mass index (BMI)	0.4	1.7	3.2	0.3	1.3	0.6	-1.8	-1.8	1.2	-1.4
Impedance of leg (left)	0.8	4.1	19.8	-0.6	0.6	0.6	-0.2	2.7	-4.5	-0.3
Leg predicted mass (left)	0.6	3.0	5.5	-0.6	1.5	1.0	-1.8	-2.3	2.3	-2.0
Trunk fat mass	0.5	2.3	4.4	-1.0	1.9	1.2	-2.0	-1.1	-0.3	-2.1
Waist circumference	0.9	3.1	6.8	-0.5	2.4	1.2	-2.6	-1.3	-0.4	-2.4
Number of incorrect matches in round	0.5	0.8	2.6	-0.9	0.7	1.6	-0.6	-0.2	-0.5	-0.8
Past tobacco smoking	0.4	0.7	2.6	-1.1	0.3	1.6	-0.6	0.7	-0.1	-0.2
Alcohol usually taken with meals	0.9	1.5	3.1	-1.0	1.6	-0.2	-1.4	1.4	-0.2	-1.8
Nervous feelings	0.3	0.6	1.4	-0.5	-1.0	-0.9	0.9	-0.3	-0.3	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	0.3	-0.8	-0.3	0.7	-0.4	0.4	0.6
Hearing difficulty/problems with background noise	0.2	0.4	1.2	1.1	-0.1	0.6	0.1	0.3	0.9	0.2
Hair/balding pattern: Pattern 2	1.2	1.6	3.8	0.1	1.4	-0.2	-1.6	-0.4	-1.9	-1.5
Had menopause	0.3	0.3	1.4	-0.6	0.5	1.2	-0.2	0.2	-0.1	-0.5
Had other major operations	2.5	3.1	6.6	-2.6	1.6	1.1	-1.6	-1.2	-2.1	-1.7
Forced vital capacity (FVC)	0.8	3.0	7.4	-2.7	1.4	1.7	-1.5	0.1	-2.3	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.7	-1.3	1.1	0.3	-1.2	0.2	-0.2	-0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.0	-0.2	0.6	-0.9	-1.0	0.2	-0.1	-0.6
Qualifications: None of the above	0.5	1.0	2.8	1.7	-0.7	-0.5	0.3	1.7	0.5	0.7
Financial difficulties in last 2 years	0.2	0.3	0.8	0.6	-0.4	-0.6	0.4	-0.4	0.9	0.2
Mouth/teeth dental problems	0.2	0.4	1.2	-0.7	0.2	0.9	-0.2	-1.1	0.4	-0.0
Heart attack	0.8	1.1	4.6	1.3	-0.7	-2.1	0.2	0.2	0.6	0.4
Allergy	0.2	0.5	1.7	0.3	0.3	1.3	-0.8	-0.0	-1.0	0.0
Pain all over the body in last month	0.5	0.5	0.9	-0.4	0.9	0.1	-0.9	-0.7	-0.6	-0.9
Diabetes (self-reported)	0.3	0.4	1.4	0.2	0.5	-0.0	-0.6	-1.2	-0.4	-0.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	0.4	0.1	-0.8	0.6	0.8	0.5	-0.1
Medication: Ramipril	0.8	1.1	2.2	0.1	-1.2	-0.8	1.2	-1.5	0.9	1.0
Medication: Simvastatin	0.2	0.3	0.8	-0.3	0.5	-0.1	-0.7	-0.9	0.1	-0.6
Fluid intelligence score	1.8	3.7	7.5	-2.2	1.9	1.3	-1.9	-0.5	-2.7	-2.1
Illnesses of siblings	0.7	0.9	4.4	2.1	0.7	0.0	-0.3	1.2	-0.0	-0.4
Neuroticism score	0.2	0.5	1.2	-1.1	0.3	0.7	-0.4	-0.5	-1.1	-0.2
Weight	0.7	3.4	6.4	-1.0	2.2	1.4	-2.5	-1.9	0.5	-2.5
Impedance of arm (right)	0.7	3.2	9.0	-0.2	-1.6	-1.0	2.5	3.0	-0.6	1.8
Arm fat percentage (right)	0.2	0.6	1.1	0.1	0.9	0.4	-1.1	-0.8	0.8	-0.9
Trunk fat-free mass	0.9	5.4	10.6	-1.2	2.8	2.2	-3.0	-1.9	0.6	-3.3
Hip circumference	0.5	2.1	3.4	0.1	1.5	1.4	-1.7	-1.5	1.5	-1.8
Time employed in main current job	0.4	0.5	1.9	-1.4	-0.5	0.5	0.4	-0.7	0.1	0.4
Alcohol intake versus 10 years previously	1.6	2.4	5.8	2.4	-1.7	-1.4	1.5	-0.4	1.0	1.7
Father’s age at death	0.2	0.2	1.1	0.2	0.4	0.5	0.3	1.0	-0.0	-0.2
Worrier / anxious feelings	1.2	2.3	5.0	0.5	-2.1	-1.0	2.2	0.7	0.3	2.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	3.6	-0.3	0.8	-1.9	-0.6	-1.0	1.1	-1.0
Falls in the last year	0.8	1.1	2.2	-1.1	1.1	-0.5	-1.1	0.5	-1.5	-1.2
Hair/balding pattern: Pattern 3	3.4	5.0	8.3	1.0	-2.8	-2.1	2.9	-0.9	2.1	2.9
Number of live births	0.7	0.9	3.9	2.0	-0.8	0.4	0.8	0.5	0.6	0.7
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.7	-1.6	0.9	1.2	-0.9	0.4	-1.1	-0.7
Pulse rate	0.2	0.4	0.8	0.4	0.9	-0.1	-0.6	-0.1	0.9	-0.8
Happiness	1.0	1.2	2.7	0.4	1.4	0.7	-1.6	-0.5	-0.7	-1.6
Noisy workplace	1.6	2.0	4.5	2.1	-1.6	-1.0	1.4	-0.2	1.3	1.4
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.0	-1.2	-0.8	-0.9	0.7	0.6	-1.4	0.6
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.8	5.0	1.7	-2.0	-1.3	2.0	0.9	1.2	2.2
Mouth/teeth dental problems: Dentures	0.3	0.5	1.9	1.4	0.2	0.2	-0.4	1.2	-0.1	-0.4
Asthma	0.3	0.7	2.8	0.1	-0.6	-1.7	0.8	0.4	0.6	0.5
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	3.1	-1.1	1.8	0.6	-1.5	-1.3	-0.6	-1.7
Medication: Cholesterol lowering	0.3	0.5	1.7	0.8	-0.0	-0.9	-0.3	-1.3	0.2	-0.1
Depression (self-reported)	0.6	0.8	1.2	0.2	-1.1	-0.9	1.1	1.0	-0.2	1.0
Medication: Lansoprazole	6.4	7.3	13.6	-1.1	3.5	2.5	-3.7	-1.5	-1.6	-3.6
Prospective memory result	0.5	0.6	1.5	1.2	-0.3	0.9	0.4	-0.1	1.1	0.6
Lung cancer (father)	1.0	1.2	3.2	0.9	-1.5	-0.5	1.8	-0.0	0.2	1.4
Illnesses of mother	0.5	0.7	3.4	0.1	-0.3	-1.8	0.1	-0.7	0.7	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.1	-1.4	0.2	1.2	-0.1	0.3	-1.1	-0.1
Pulse wave Arterial Stiffness index	1.5	1.8	7.4	-1.7	0.9	-0.5	-0.6	0.2	-2.7	-0.9
Impedance of arm (left)	0.9	4.0	10.4	-0.2	-1.9	-1.0	2.8	3.2	-0.7	2.1
Arm fat mass (right)	0.4	1.6	2.9	-0.2	1.4	0.7	-1.7	-1.4	0.8	-1.6
Trunk predicted mass	1.0	5.5	10.6	-1.3	2.8	2.1	-3.1	-2.0	0.6	-3.3
Standing height	0.5	4.6	7.8	-2.7	2.3	2.1	-2.0	0.0	-1.9	-2.8
Length of working week for main job	0.8	0.9	3.6	-1.4	-0.2	0.5	-0.3	-1.9	0.2	0.3
Exposure to tobacco smoke at home	0.5	0.5	1.1	0.3	1.0	-0.4	-1.1	0.3	0.4	-1.0
Breastfed as a baby	1.4	1.7	2.6	-1.1	1.6	1.1	-1.5	1.4	-1.0	-1.5
Tense / ‘highly strung’	0.1	0.1	0.5	-0.7	-0.2	0.2	0.5	-0.3	-0.2	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	5.0	0.6	0.0	-0.9	0.1	2.2	-0.7	0.1
Hair/balding pattern: Pattern 4	0.8	1.8	4.6	-2.1	1.1	1.9	-1.3	-0.6	-0.7	-1.1
Birth weight of first child	0.8	1.5	3.3	-1.8	1.0	0.8	-1.3	-0.1	-1.5	-1.2
Peak expiratory flow (PEF)	0.5	1.2	2.1	-1.4	1.4	0.3	-1.2	0.5	-1.1	-1.3
Pulse wave reflection index	1.4	1.7	6.0	-1.5	1.1	-0.2	-1.1	-0.2	-2.5	-1.2
Ever highly irritable/argumentative for 2 days	0.7	0.8	3.2	0.9	-0.2	-0.1	0.2	-1.8	1.2	0.3
Loud music exposure frequency	2.4	2.7	5.0	0.0	2.0	1.7	-2.2	-1.1	-0.9	-2.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	-0.7	-0.5	0.6	0.6	-0.0	-0.6	0.4
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	8.0	0.1	-0.0	-2.8	0.5	1.6	-0.1	0.2
Blood clot in the leg (DVT)	0.9	1.1	3.3	-0.0	0.8	-1.8	-0.8	-0.9	1.4	-0.6
Medication: Paracetamol	1.8	3.0	6.9	2.2	-1.4	-1.7	1.6	0.2	2.6	1.3
Headache pain in last month	0.7	1.1	4.3	-0.1	0.3	2.1	-0.5	1.3	-1.3	-0.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.9	-1.0	0.9	0.1	-0.5	0.8	-0.8	-0.6
Glaucoma (self-reported)	1.9	2.2	3.2	-1.8	1.7	0.3	-1.8	-1.3	-1.2	-1.7
Gout (self-reported)	1.1	1.5	2.9	1.6	-1.7	1.0	1.5	0.4	0.4	1.3
Hypothyroidism/myxoedema (self-reported)	2.8	5.5	9.5	-2.1	1.9	3.1	-2.7	-1.0	-2.8	-2.1
Medication: Amlodipine	0.3	0.4	1.0	-0.8	0.2	-0.9	-0.4	-1.0	-0.7	-0.1
Medication: Ventolin 100micrograms inhaler	0.8	1.0	6.0	-0.8	0.2	-2.4	0.1	0.5	-0.2	-0.2
Birth weight	0.2	0.3	1.4	-1.2	-0.3	-0.7	0.6	0.1	-0.2	0.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.6	1.3	-0.5	-1.0	0.6	0.8	-0.3	0.7
High blood pressure (siblings)	0.8	1.2	3.4	-1.9	0.3	1.8	-0.6	-0.2	-0.9	-0.4
Forced vital capacity (FVC), Best measure	0.7	2.5	7.1	-2.7	1.1	1.6	-1.0	-0.1	-2.0	-1.1
Body fat percentage	0.4	1.5	2.9	-0.5	1.6	1.0	-1.7	-0.8	-0.6	-1.6
Leg fat percentage (right)	0.3	1.1	2.5	0.1	1.3	1.1	-1.6	-0.5	-0.7	-1.3
Arm fat-free mass (right)	1.2	6.0	10.8	-1.3	2.8	1.9	-3.3	-2.7	0.2	-3.2
Exposure to tobacco smoke outside home	0.5	0.7	1.7	1.1	-0.6	-1.0	0.6	-0.4	1.3	0.5
Comparative body size at age 10	0.3	0.7	2.1	-0.1	-0.5	1.0	0.1	1.3	1.4	0.2
Number of full brothers	0.2	0.2	0.6	0.4	-0.8	0.3	0.4	0.0	0.0	0.7
Worry too long after embarrassment	1.0	1.6	3.4	-1.0	1.8	-0.1	-1.8	-1.1	-0.9	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	-0.8	0.4	-0.9	-0.4	1.0	0.1	-0.4
Wheeze or whistling in the chest in last year	1.5	2.6	5.4	-2.3	1.2	-0.9	-1.4	-2.0	-1.7	-1.4
Number of children fathered	1.9	2.2	4.5	0.8	2.1	-1.0	-2.0	-0.7	0.6	-2.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	-0.3	-0.4	-0.8	-0.2	0.9	-0.6	0.6
Age at first live birth	0.2	0.4	1.6	-0.7	0.2	1.3	-0.2	-0.2	-0.7	-0.4
Pulse wave peak to peak time	0.9	1.1	5.2	1.1	-0.4	0.9	0.2	-0.1	2.3	0.4
Health satisfaction	1.5	1.9	2.7	-0.8	1.6	1.6	-1.7	-1.3	-0.9	-1.5
Shortness of breath walking on level ground	2.1	2.5	6.6	-0.1	1.4	2.6	-1.8	-0.0	-1.8	-1.5
Qualifications: College or University degree	0.2	0.6	1.5	-1.2	0.7	-0.1	-0.7	-0.2	-1.1	-0.8
Eye problems/disorders: None of the above	0.6	0.7	2.0	0.9	-0.5	-0.6	0.9	0.6	1.4	0.4
Mouth/teeth dental problems: Loose teeth	2.5	3.0	5.2	2.3	-1.5	-1.9	2.1	1.0	1.7	1.3
Emphysema/chronic bronchitis	0.4	0.5	1.6	-0.7	0.4	-0.5	-0.2	-1.3	-0.5	-0.8
Medication for pain relief, constipation, heartburn	0.5	0.9	1.6	-0.3	-1.3	-0.3	1.0	1.1	-0.9	1.3
Neck or shoulder pain in last month	0.6	0.9	2.5	1.6	-0.5	-0.4	0.8	0.9	1.1	0.7
Medication: Blood pressure	0.1	0.2	0.7	0.4	-0.3	-0.1	0.1	-0.7	0.8	0.2
Angina (self-reported)	0.5	0.7	1.3	-0.7	0.7	0.5	-1.1	-0.6	-1.1	-0.7
Migraine (self-reported)	0.5	0.7	2.6	-0.7	-0.6	1.6	0.3	-0.5	-0.8	0.5
Medication: Ibuprofen	0.7	0.8	1.9	0.1	1.4	0.6	-1.1	-0.2	-0.6	-1.2
Medication: Allopurinol	0.3	0.5	1.6	1.0	-0.5	1.3	0.4	-0.2	0.5	0.2
Medication: Omeprazole	2.1	2.5	4.4	-1.6	2.0	0.5	-2.1	-0.2	-1.7	-1.8
Medication: Seretide 50 evohaler	2.0	2.3	7.2	-2.7	1.3	-0.3	-1.3	-1.5	-1.0	-1.4
Mean time to correctly identify matches	0.7	1.3	3.7	0.7	-0.4	-1.5	0.7	-1.9	1.4	0.3
Heart disease (mother)	0.6	0.7	1.6	-1.3	-0.5	-0.7	0.8	-1.3	-0.0	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	5.1	1.9	-0.4	0.4	0.7	2.3	0.2	0.5
Whole body fat mass	0.6	2.3	4.6	-0.6	2.0	1.1	-2.1	-1.3	-0.0	-2.1
Leg fat mass (right)	0.5	2.1	4.4	-0.3	1.8	1.2	-2.1	-1.3	-0.1	-2.0
Arm predicted mass (right)	1.2	6.0	10.8	-1.3	2.8	2.1	-3.3	-2.5	0.0	-3.3
Pulse rate, automated reading	0.3	0.8	2.0	0.5	1.4	0.1	-1.4	0.2	-0.4	-1.2
Alcohol intake frequency.	1.0	2.3	3.7	1.4	-1.9	-1.1	1.9	-0.0	1.7	1.6
Comparative height size at age 10	0.4	2.1	4.8	-0.1	1.0	2.2	-1.2	1.7	-1.5	-1.5
Number of full sisters	0.3	0.3	1.8	0.2	-0.3	-0.3	0.2	-1.3	0.3	0.4
Suffer from ‘nerves’	0.4	0.6	2.4	-0.5	-0.3	0.1	0.0	-1.6	-1.0	0.4
Overall health rating	0.2	0.4	1.4	1.2	0.1	-0.5	-0.2	-0.6	0.5	-0.3
Chest pain or discomfort	0.6	0.8	3.7	-0.1	0.7	-0.7	-1.0	-0.0	-1.9	-0.6
Had major operations	0.3	0.3	1.2	-0.6	0.4	-1.1	-0.1	0.0	-0.4	-0.8
Age at last live birth	0.1	0.1	0.3	0.5	-0.4	-0.6	0.4	-0.2	-0.2	0.1
Family relationship satisfaction	0.2	0.3	0.6	0.8	-0.4	-0.3	0.4	-0.4	0.8	0.1
Leg pain on walking	0.3	0.4	1.5	1.2	0.0	0.9	-0.3	0.6	0.4	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.0	-0.0	1.4	0.3	-0.8	-0.5	0.8	-1.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.9	-0.3	-0.3	-0.9	0.4	-0.1	0.1	0.5
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	1.2	-0.1	1.0	0.7	-0.9	-1.1	-0.0	-1.0
Medication: Aspirin	1.1	1.5	3.2	-0.8	1.4	1.0	-1.8	-0.8	-1.0	-1.4
Supplements: Vitamin C	0.7	0.9	2.6	1.6	-0.4	-0.1	0.5	1.0	1.2	0.6
Knee pain experienced in last month	0.4	0.7	1.6	0.3	0.8	1.2	-1.0	0.7	0.3	-0.9
Hypertension (Self-reported)	0.0	0.1	0.1	0.2	-0.4	0.3	0.0	-0.3	0.1	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.4	5.2	13.4	-2.3	2.0	2.0	-2.4	-0.5	-3.7	-2.0
Illnesses of father: Heart disease	1.7	2.4	3.7	1.0	-1.6	-1.9	1.6	-1.0	1.8	1.6
Illnesses of siblings: Diabetes	0.6	0.7	2.6	-1.6	-0.3	1.1	0.2	-0.3	-1.1	0.2
Smoking status: Previous	0.8	1.2	3.4	1.7	-0.8	-1.8	0.9	-0.2	0.7	0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	5.7	-1.1	2.4	2.2	-2.0	-0.8	0.5	-2.4
Whole body fat-free mass	0.8	4.7	8.1	-1.1	2.4	1.8	-2.7	-2.4	1.2	-2.9
Leg fat-free mass (right)	0.7	3.9	8.3	-1.2	1.8	0.7	-2.0	-2.9	2.2	-2.2
Arm fat percentage (left)	0.2	0.6	1.1	0.2	0.8	0.5	-0.9	-1.0	1.0	-0.8
Average weekly red wine intake	0.3	0.5	2.0	-1.4	-0.2	-0.5	0.7	0.8	-0.0	0.0
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.0	0.3	-0.9	-1.7	1.3	1.1	-0.2	1.2
Mood swings	0.2	0.4	2.0	0.8	0.1	1.4	-0.1	-0.3	0.4	0.0
Loneliness, isolation	0.5	0.7	2.4	0.1	-0.9	1.6	0.5	0.8	-0.3	0.6
Long-standing illness, disability or infirmity	0.6	0.9	1.1	1.0	1.0	0.2	-1.1	1.1	-1.0	-1.1
Ever had bowel cancer screening	1.0	1.2	5.4	-0.3	-0.6	-0.2	0.4	2.3	-1.5	0.5
Diabetes diagnosed by doctor	0.4	0.7	1.5	-0.2	0.6	0.2	-0.8	-1.2	-1.1	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.8	0.9	0.4	0.8	-0.4	-0.2	0.3	-0.3
Friendships satisfaction	0.2	0.3	0.7	-0.2	0.5	0.2	-0.8	-0.3	-0.7	-0.5
Qualifications: nursing, teaching	1.0	1.5	4.9	-2.2	1.2	-0.2	-0.7	-0.9	-1.1	-1.3
Commuting to job workplace: Walk	0.1	0.1	0.4	0.4	-0.6	-0.0	0.4	-0.3	-0.0	0.4
Eye problems/disorders: Cataract	0.4	0.4	1.7	-0.2	-0.7	-0.6	0.3	-1.3	-0.1	0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.6	-0.0	-0.8	-0.4	0.8	0.0	-0.3	0.4
Medication for cholesterol	0.5	0.8	3.7	-0.9	-0.3	-1.9	0.4	-0.6	0.2	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.8	0.1	0.4	0.6	-0.5	0.5	-0.9	-0.6
Back pain experienced in last month	0.8	1.1	2.6	1.2	0.7	0.5	-0.5	-1.6	1.6	-0.5
Mineral and other dietary supplements	0.5	0.7	1.8	0.4	0.7	1.0	-0.5	0.6	-1.4	-0.9
Breast cancer (self-reported)	0.2	0.3	0.7	0.2	-0.7	-0.1	0.8	0.0	0.4	0.8
Asthma (self-reported)	0.4	0.9	3.9	-0.0	-0.7	-2.0	1.0	0.4	0.5	0.7
Osteoporosis (self-reported)	0.7	0.8	2.2	-0.3	0.5	-1.4	-0.9	-0.2	-1.5	-0.6
Osteoarthritis (self-reported)	1.1	1.4	5.5	1.8	-0.0	0.9	0.1	2.4	-0.1	0.3
Medication: Aspirin	0.6	0.8	1.8	-0.6	1.0	0.9	-1.3	-0.6	-0.8	-1.0
Medication: Gliclazide	0.5	0.6	2.6	1.6	-0.3	0.4	0.1	0.9	-0.8	0.2
Illnesses of father: None of the above (group 1)	0.5	0.7	3.5	0.5	0.2	1.9	-0.2	0.8	0.2	-0.5
Smoking status: Current	1.0	1.6	2.9	1.6	-1.7	-0.5	1.7	-0.1	0.4	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	5.3	-2.3	1.2	2.3	-1.2	0.2	-1.8	-0.9
Whole body water mass	0.8	4.7	8.1	-1.1	2.4	1.7	-2.7	-2.5	1.2	-2.8
Leg predicted mass (right)	0.7	4.0	8.6	-1.2	1.8	0.7	-2.0	-2.9	2.2	-2.3
Arm fat mass (left)	0.5	2.0	3.6	-0.4	1.7	1.0	-1.9	-1.6	0.7	-1.8
Number of self-reported non-cancer illnesses	0.1	0.1	0.3	0.6	-0.0	-0.1	-0.0	0.5	-0.5	-0.2
Average weekly champagne plus white wine intake	2.8	3.9	10.2	-1.8	1.8	3.2	-1.9	-0.2	-1.7	-2.0
Miserableness	0.3	0.6	1.5	-0.0	0.5	1.1	-0.6	0.1	-1.2	-0.7
Guilty feelings	1.1	1.7	2.8	-1.1	1.6	0.7	-1.4	-1.7	0.3	-1.6
Wears glasses or contact lenses	1.3	1.5	3.8	-1.7	1.1	0.5	-0.9	0.0	-1.9	-1.2
Ever taken oral contraceptive pill	0.4	0.5	1.4	-0.0	1.2	-0.0	-0.9	-0.4	0.3	-1.0
Hearing aid user	0.8	0.9	4.7	0.4	0.7	0.4	-0.5	2.2	-0.7	-0.5
Mother’s age at death	0.4	0.5	2.1	-0.2	-0.3	-0.6	0.5	1.4	-0.9	0.3
Financial situation satisfaction	0.3	0.4	1.0	0.4	0.6	1.0	-0.8	-0.0	0.1	-0.9
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	-0.4	-0.7	0.8	0.6	0.2	0.1	0.7
Commuting to job workplace: Public transport	0.5	0.6	1.8	-0.4	1.3	0.1	-0.6	0.0	-0.6	-1.2
Eye problems/disorders: Glaucoma	1.3	1.5	2.6	-1.2	1.6	0.6	-1.6	-0.2	-1.3	-1.5
Medication: Blood pressure	0.3	0.6	1.6	1.1	-0.1	1.1	-0.1	1.3	0.3	0.1
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.2	1.3	-0.8	-0.6	1.1	1.5	-0.2	0.7
Supplements: Fish oil (including cod liver oil)	1.7	2.2	4.6	0.3	-1.6	-1.2	1.7	-1.2	2.1	1.7
High cholesterol (Self-reported)	0.7	1.3	2.9	-0.0	1.3	0.4	-1.7	-1.4	-0.5	-1.4
Medication: Bendroflumethiazide	0.5	0.7	1.8	0.2	1.1	0.7	-1.3	0.1	0.4	-1.2
Medication: Paracetamol	0.9	1.4	2.7	1.4	-0.9	-1.4	1.0	0.7	1.6	1.1
Medication: Lisinopril	1.3	1.7	4.3	1.3	1.0	2.1	-1.2	1.2	0.9	-1.0
Medication: Atorvastatin	3.2	4.0	6.0	-1.0	2.2	2.2	-2.5	-1.2	-2.0	-2.4
Illnesses of father: High blood pressure	0.4	0.5	1.5	-0.2	0.5	-0.2	-0.4	1.2	-1.1	-0.3
Alcohol drinker status: Never	1.3	1.5	2.9	0.7	-1.7	-1.1	1.6	0.4	0.6	1.6
Ever smoked	0.7	1.2	3.2	0.5	-1.1	-1.8	1.4	-0.9	0.1	0.9
Basal metabolic rate	0.9	4.8	8.3	-1.0	2.5	1.8	-2.8	-2.5	1.1	-2.9
Leg fat percentage (left)	0.6	2.0	4.4	-0.5	1.8	1.1	-2.1	-0.9	-1.0	-1.8
Arm fat-free mass (left)	1.3	6.7	12.7	-1.3	3.1	1.9	-3.6	-2.6	0.1	-3.5
Number of operations (self-reported)	0.8	1.2	4.1	-1.5	-0.7	-0.8	0.9	-0.1	-2.0	0.5
Average weekly beer plus cider intake	0.7	1.1	4.1	0.2	-0.6	-0.6	0.5	-2.0	1.4	0.6
Irritability	1.5	2.6	9.0	-1.7	1.3	1.1	-0.9	-3.0	0.6	-1.5
Risk taking	0.2	0.3	0.7	-0.1	0.6	-0.3	-0.4	-0.8	0.8	-0.7
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.1	0.8	0.5	0.4	-0.4	1.4	-0.6	-0.6
Fractured/broken bones in last 5 years	0.9	1.1	3.0	1.7	-0.1	-1.7	-0.0	1.4	0.1	-0.0
Age started oral contraceptive pill	3.1	3.8	7.8	1.4	-1.8	-0.6	2.4	2.8	1.8	2.1
Diastolic blood pressure, automated reading	0.5	1.6	3.0	1.6	-1.7	-0.5	1.4	0.0	0.1	1.7
Ever depressed for a whole week	0.9	1.2	2.3	-1.5	0.9	-0.5	-1.4	-0.0	-1.4	-0.9
Unable to work because of sickness or disability	0.1	0.2	0.5	-0.4	0.2	-0.3	-0.5	-0.7	-0.0	-0.4
Commuting to job workplace: Cycle	0.4	0.5	1.8	-0.9	-0.5	0.1	0.3	1.3	-0.0	0.7
Myopia	0.4	0.6	2.0	-1.2	0.2	0.6	-0.0	-1.4	-0.4	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.8	-0.9	0.8	-0.3	-0.3	-0.0	-0.6	-0.6
Cholesterol lowering medication	1.7	2.5	5.0	-0.5	2.0	1.7	-2.2	-0.1	-0.5	-2.2
Medication: Omeprazole (e.g. Zanprol)	2.5	3.1	4.9	-2.0	2.1	0.9	-2.2	-0.3	-1.9	-2.0
Pain experienced in last month	0.6	1.0	3.9	-1.2	-0.4	-2.0	0.6	-0.8	-0.2	0.4
Supplements: Calcium	0.8	0.9	2.2	0.2	-0.9	-1.5	1.0	-0.7	0.8	1.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.8	-0.9	-0.1	-0.2	0.2	-0.6	0.6	0.2
Heart attack/myocardial infarction (self-reported)	0.8	1.1	4.7	1.2	-0.9	-2.2	0.4	0.2	0.5	0.6
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	3.1	0.3	0.8	-1.8	-0.8	-0.8	1.5	-0.6
Heart disease (siblings)	1.2	1.5	4.8	-0.8	-1.1	-2.2	0.9	-1.1	0.7	1.1
Alcohol drinker status: Previous	0.8	0.9	1.9	0.9	-1.2	0.6	1.4	0.5	0.3	1.1
Pack years of smoking	0.1	0.1	0.3	0.1	0.0	-0.4	-0.1	-0.6	-0.4	-0.0
Impedance of whole body	0.7	3.5	10.8	-0.6	-0.8	-0.2	1.4	3.3	-3.0	1.1
Leg fat mass (left)	0.7	2.9	5.8	-0.7	2.1	1.2	-2.4	-1.7	-0.3	-2.3
Arm predicted mass (left)	1.1	5.7	10.7	-1.2	2.8	2.0	-3.3	-2.5	0.3	-3.1