Hub : Genes

EPS8L2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3050	0.0540	1.5e-13	0.072	0.151	0.143	NA	0.122	4.0e-09	6.1e-18	5.1e-17	NA	1.1e-14
2	GTEx	Adrenal Gland	0.4143	0.0933	5.4e-05	0.186	NA	0.162	NA	0.190	3.1e-07	NA	2.0e-06	NA	2.3e-07
3	GTEx	Artery Aorta	0.2350	0.0700	1.9e-04	0.129	NA	0.181	NA	0.171	1.4e-07	NA	2.9e-10	NA	1.1e-09
4	GTEx	Artery Tibial	0.3052	0.0622	3.3e-09	0.212	NA	0.233	NA	0.233	1.6e-16	NA	3.1e-18	NA	3.6e-18
5	GTEx	Brain Cerebellar Hemisphere	0.4850	0.1200	8.8e-05	0.141	NA	0.226	NA	0.215	1.9e-04	NA	1.7e-06	NA	3.3e-06
6	GTEx	Brain Cerebellum	0.4200	0.1080	5.3e-06	0.263	NA	0.374	NA	0.261	2.1e-08	NA	5.3e-12	NA	2.5e-08
7	GTEx	Brain Putamen basal ganglia	0.2870	0.1120	4.2e-03	0.104	NA	0.073	NA	0.280	1.9e-03	NA	8.6e-03	NA	2.3e-07
8	GTEx	Esophagus Muscularis	0.3540	0.0780	1.4e-08	0.227	NA	0.185	NA	0.205	6.4e-14	NA	2.0e-11	NA	1.3e-12
9	GTEx	Heart Left Ventricle	0.3249	0.0744	1.2e-06	0.213	NA	0.174	NA	0.216	1.5e-11	NA	1.5e-09	NA	9.8e-12
10	ROSMAP	Brain Pre-frontal Cortex	0.1346	0.0341	5.7e-06	0.068	0.030	0.078	0.04	0.078	4.1e-09	7.8e-05	3.1e-10	5.7e-06	2.7e-10
11	TCGA	Brain Lower Grade Glioma	0.0647	0.0253	7.1e-06	0.018	0.031	0.048	NA	0.024	3.7e-03	1.7e-04	3.8e-06	NA	8.0e-04
12	TCGA	Thyroid Carcinoma	0.0470	0.0240	1.2e-03	0.048	0.017	0.015	NA	0.032	1.7e-05	7.8e-03	1.2e-02	NA	3.7e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.9	1.5	2.4	-0.8	-0.5	-1.4	-1.1	1.4	1.5	-1.2	-1.0	-0.3	-1.5	1.5	-1.6
Bipolar Disorder or Schizophrenia	0.5	1.3	3.7	-0.7	0.1	0.2	-0.8	-1.6	-1.1	-1.9	-0.4	-1.7	-1.4	-1.0	1.0
Depressed Affect (Nagel 2018)	0.4	0.8	2.3	1.1	-0.1	0.3	-0.8	-1.1	-0.6	-1.1	0.1	-1.5	0.0	-1.0	1.2
Depression (Nagel 2018)	1.8	2.7	5.8	-0.2	-1.7	-0.6	-2.3	-1.0	-1.0	-2.3	-2.0	-2.4	-1.9	-1.2	1.1
Intelligence (Savage-Jansen 2018)	0.7	2.3	4.5	-1.8	1.1	1.8	0.3	-1.5	-1.4	-1.3	1.7	-1.0	-2.1	-1.4	1.8
Neuroticism (Nagel 2018)	0.1	0.2	1.2	1.1	-0.2	0.2	-0.2	-0.2	0.7	0.2	0.6	0.1	0.0	0.2	0.7
Schizophrenia (2018)	1.3	2.7	9.3	-0.9	0.3	1.2	-0.1	-3.0	-2.4	-0.7	0.3	-1.2	0.0	-2.6	2.6
Schizophrenia vs Biploar Disorder	0.1	0.2	1.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.6	1.2
Worry (Nagel 2018)	0.6	1.3	3.1	0.6	-0.6	-0.7	0.5	1.6	1.5	1.4	0.1	1.8	0.6	1.5	-0.8
Alzheimer’s Disease (in mother)	1.8	2.1	6.2	0.8	1.1	2.5	2.2	-1.5	-0.9	0.5	2.5	0.5	0.2	-0.8	1.3
Alzheimer’s Disease (in father)	0.2	0.3	1.4	-0.5	0.8	-0.0	0.5	-0.0	0.3	-1.2	-0.0	-0.2	-0.7	0.1	0.2
Alzheimer’s Disease (including proxy)	1.6	2.2	6.7	1.1	1.4	2.4	2.6	-1.3	-0.7	0.3	2.4	0.5	0.6	-0.7	1.6
Crohns Disease (2017)	1.0	2.1	8.4	-0.1	-0.2	0.4	-0.9	-1.9	-2.9	-0.7	-0.8	-1.7	1.1	-2.5	1.1
Irritable Bowel Disease (IBD)	0.8	1.9	5.6	0.9	-0.0	0.7	-0.4	-1.3	-2.4	-0.5	0.4	-1.2	2.3	-2.3	1.0
Ulcerative Colitis (UC)	0.5	0.9	5.9	1.5	-0.2	0.1	-0.3	0.0	-0.7	-0.5	0.7	-0.5	2.4	-1.1	0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.2	0.4	2.1	0.0	1.5	0.4	0.3	-0.1	0.6	-1.2	0.9	-0.3	0.6	0.0	0.1
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.9	-0.9	1.1	2.0	0.6	-1.4	-1.1	-0.8	1.8	-0.6	-1.6	-1.0	1.1
Breast Cancer	2.7	6.5	18.1	-3.5	1.4	3.1	3.0	-0.9	-0.9	-2.6	2.9	-0.6	-4.2	-1.7	2.6
Ovarian Cancer	1.5	2.0	4.2	1.9	0.7	1.7	1.4	-1.0	-1.1	-1.1	1.9	-1.1	-0.1	-1.7	2.1
Prostate Cancer	0.7	1.0	3.7	1.9	0.6	0.9	0.6	0.3	0.8	1.6	0.5	1.5	1.0	0.4	0.5
Age at First Birth	1.2	1.7	9.9	2.5	-0.2	0.0	-1.0	-0.6	-1.3	0.8	0.0	0.0	3.1	-1.1	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.3	2.9	0.3	1.7	1.3	1.4	-1.6	-1.3	0.6	1.1	-0.6	0.4	-1.1	1.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.7	1.1	4.9	-0.3	-0.2	0.2	-0.8	-1.4	-2.2	-0.3	0.0	-1.1	0.9	-1.7	0.0
Mean Putamen Volume	0.4	0.5	1.2	-0.9	-0.2	-0.6	-0.5	-0.1	-0.9	0.5	-0.9	1.1	1.1	-0.3	0.6
Fasting Glucose	2.1	2.5	5.1	-0.2	2.0	1.9	1.4	-2.3	-1.7	0.2	1.4	-0.3	1.8	-1.8	1.9
HbA1C	1.6	1.8	5.0	-1.5	-0.1	0.1	-0.9	-1.0	-1.3	-2.2	-0.2	-2.1	-2.2	-1.2	0.6
HDL Cholesterol	2.8	4.7	10.6	2.6	-1.2	-1.5	-1.2	3.2	3.3	1.4	-1.3	2.0	1.4	3.0	-2.2
LDL Cholesterol	0.8	1.2	3.3	-0.0	1.7	1.6	1.8	-0.7	-0.7	0.3	1.8	0.5	-0.5	-0.8	0.8
Lupus	9.4	14.2	27.8	-4.0	3.7	3.2	1.9	-4.4	-5.2	-2.6	2.1	-3.6	-2.1	-4.9	5.3
Neuroticism (2016)	1.6	2.3	5.3	1.7	-0.9	-1.7	-1.0	2.3	1.6	1.1	-0.8	1.4	2.0	1.7	-1.2
Primary Biliary Cirrhosis	1.5	2.1	5.9	-0.8	1.7	1.0	0.4	-2.2	-1.8	-0.7	0.8	-1.7	-0.6	-1.7	2.4
Rheumatoid Arthritis	0.2	0.2	1.0	-0.5	0.5	-0.3	-0.3	-0.6	-0.2	-1.0	-0.3	-0.6	-0.0	-0.5	0.0
Schizophrenia (2014)	0.5	1.1	4.1	-1.5	0.1	0.0	-1.2	-2.0	-1.0	-0.7	-0.9	-0.8	-0.9	-0.8	1.1
Triglycerides	1.1	1.7	5.2	-2.3	0.7	1.1	0.9	-1.5	-1.9	-0.5	1.0	-0.6	-1.2	-1.7	1.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	3.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.8	0.6
Ulcerative Colitis	0.4	0.6	3.9	1.5	0.1	0.2	0.1	-0.2	-0.8	-0.1	0.6	0.1	2.0	-0.7	-0.2
Blood Eosinophil Count	0.8	6.4	18.1	-4.3	2.4	2.2	0.9	-2.5	-2.7	-2.3	1.0	-2.0	-2.8	-2.8	2.5
Blood Platelet Count	0.4	4.2	19.4	4.4	0.6	0.8	0.7	-1.0	0.7	3.8	0.1	2.2	2.9	1.2	-0.3
Blood Red Count	0.3	3.3	9.1	-0.9	-0.5	-3.0	-1.4	2.9	1.4	0.7	-1.5	-0.2	2.5	1.6	-2.3
Blood White Count	0.3	2.1	13.0	-0.7	3.6	0.9	2.0	0.1	0.1	-0.2	1.6	-0.5	-1.2	-0.1	1.5
Heel T-Score	0.2	1.6	5.0	-1.5	-1.1	-2.2	-1.0	0.8	-0.2	0.9	-2.1	-1.2	-0.0	0.6	-1.6
BMI	0.8	4.8	21.7	3.1	1.9	1.0	2.8	-0.7	-1.2	3.0	1.2	0.8	4.7	-0.9	0.6
Height	0.7	12.8	19.8	-2.6	4.1	4.3	2.7	-3.9	-3.1	-3.2	4.5	-1.7	-4.2	-3.7	3.9
Waist Hip Ratio (WHR)	1.8	7.9	41.1	-4.8	-0.5	0.8	-0.4	-2.2	-2.0	-3.0	-0.5	-1.8	-6.4	-1.8	2.3
Systolic Blood Pressure	0.4	2.1	7.2	0.7	1.1	-0.9	1.4	2.1	1.4	2.7	-0.6	1.1	0.9	1.7	-1.4
Smoking Status	0.4	0.9	2.2	-0.1	-0.5	0.4	1.5	1.2	1.4	-1.2	1.2	0.5	-0.6	0.7	-0.9
Allergy or Eczema	1.1	3.0	6.7	-0.2	2.6	2.2	1.6	-2.3	-1.2	-0.8	2.1	0.1	-0.5	-1.9	2.5
Cardiovascular Disease	0.4	1.5	5.1	-0.3	2.0	1.1	2.2	-0.7	-1.2	-0.1	1.3	-0.3	0.3	-1.2	1.6
Hypothyroidism (self reported)	3.5	8.1	22.1	-1.9	1.2	1.2	0.1	-4.1	-4.7	-3.0	1.0	-4.3	-0.8	-4.3	2.3
Respiratory disease	0.7	1.5	6.4	-0.8	-1.1	-2.5	-1.6	0.8	0.8	0.3	-1.7	0.6	1.0	0.7	-1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.4	2.3	-1.5	-0.4	0.5	-0.5	-0.5	-0.3	-1.2	-0.4	0.2	-0.1	-0.4	0.6
Lung FEV1/FVC ratio	0.5	2.7	9.5	1.8	-2.6	-0.9	-0.9	0.9	1.0	1.7	-1.3	0.7	3.1	1.3	-1.6
Lung FVC	0.1	0.4	1.7	0.8	-0.3	-0.1	-0.5	-1.2	-0.1	-0.1	0.7	-0.5	1.3	-0.3	0.7
Neuroticism	0.2	0.4	1.0	1.0	-0.1	-0.2	0.3	0.6	0.9	0.6	0.2	0.5	0.9	0.8	-0.4
Chronotype (morning person)	0.2	0.6	2.9	-1.1	0.5	-1.7	0.1	1.0	-0.3	0.2	-0.7	-0.2	0.2	0.3	-0.7
Hair Pigment	0.0	1.1	2.8	0.6	-0.1	0.8	0.8	-1.4	-1.2	0.6	0.8	-0.3	1.7	-1.3	1.6
Tanning	0.1	1.2	8.2	-1.3	0.4	0.2	0.4	0.6	-0.4	-2.9	1.0	-0.5	-1.1	-0.9	0.6
Hand grip strength (left)	0.7	1.9	5.6	-0.9	-0.3	0.8	-0.6	-1.5	-1.3	-2.4	0.7	-2.1	-0.6	-1.9	1.5
Number of treatments/medications taken	1.1	2.0	5.0	-0.6	1.9	1.2	1.5	-1.6	-1.6	-0.6	1.3	-1.1	-0.4	-1.7	2.2
Average weekly spirits intake	0.4	0.5	2.3	-1.5	0.7	-0.1	-0.2	-0.3	-0.1	-0.9	-0.4	-0.2	-1.1	-0.3	0.9
Sensitivity / hurt feelings	1.7	2.9	7.3	1.5	0.7	0.3	1.7	1.0	1.9	1.9	1.8	2.4	2.7	1.8	-1.2
Frequency of depressed mood in last 2 weeks	1.4	2.0	5.4	-0.2	-1.4	-0.3	-1.9	-0.9	-1.1	-2.1	-1.5	-2.3	-1.5	-1.2	0.8
Hearing difficulty/problems: Yes	1.4	2.2	5.5	1.0	-0.0	2.0	0.5	-1.7	-2.3	-0.1	1.3	-1.5	1.4	-2.2	1.3
Relative age of first facial hair	0.6	1.2	6.9	-1.8	0.1	0.8	-1.0	-0.1	-0.1	-1.5	0.2	-0.6	-2.6	-0.2	0.2
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	5.5	1.0	-0.8	0.6	-0.7	-1.7	-2.3	-1.8	0.0	-1.5	0.5	-2.2	0.3
Ever used hormone-replacement therapy (HRT)	2.1	2.7	5.8	-2.4	1.3	0.5	0.3	-1.2	-2.1	-1.7	0.7	-1.7	-1.4	-2.4	2.3
Ever had hysterectomy (womb removed)	0.5	0.5	1.9	0.8	1.4	0.9	0.9	0.4	-0.2	0.1	0.6	0.2	0.2	-0.3	1.3
Systolic blood pressure, automated reading	0.5	1.5	5.2	1.3	2.2	0.9	2.3	0.3	-0.2	1.8	1.1	0.2	0.4	-0.1	0.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.2	-1.5	-0.0	0.4	-0.9	-0.7	-0.7	-1.5	-0.1	-0.6	0.1	-0.8	-0.2
Angina	0.7	1.0	5.5	-2.3	0.8	0.4	0.3	-0.9	-0.4	-0.5	0.5	-0.2	-1.7	-0.5	0.8
Medication for hormone replacement therapy	0.1	0.2	0.8	-0.0	-0.5	0.3	0.0	-0.9	-0.1	-0.3	-0.0	0.1	-0.2	-0.3	0.7
Vitamin and mineral supplements	0.7	0.9	2.9	-0.3	-1.2	-1.7	-1.4	0.3	0.8	-0.5	-1.4	-0.1	-0.4	0.7	-0.9
Supplements: Zinc	1.4	1.6	4.0	2.0	-0.3	0.8	0.9	1.0	1.5	1.9	0.7	1.5	1.0	1.5	-0.8
Medication: Co-codamol	1.1	1.3	4.5	2.1	0.9	1.5	1.8	-0.1	-0.1	1.6	0.5	1.0	-0.0	0.3	0.8
Medication: Metformin	0.3	0.4	1.3	-1.1	0.8	0.6	0.5	-0.6	-0.5	-0.6	0.9	0.3	-0.2	-0.4	0.2
Diabetes (father)	1.0	1.3	3.1	0.9	0.8	-0.6	-0.0	1.2	0.9	1.4	0.7	1.3	1.8	1.5	-1.2
Diabetes (mother)	1.2	1.6	4.3	-2.1	-0.9	0.1	-0.5	-0.8	-1.7	-2.0	-0.4	-1.7	-0.9	-1.3	-0.5
Severe depression (siblings)	0.3	0.3	1.1	0.4	-1.0	0.2	-0.3	0.3	0.4	1.0	-0.0	0.6	0.8	0.5	-0.3
Pack years adult smoking proportion	0.5	0.8	2.8	1.3	-0.2	-1.1	-1.0	0.5	-0.1	-0.9	0.2	-1.0	1.7	-0.0	-0.8
Impedance of leg (right)	1.2	5.7	20.5	-4.5	-1.3	-1.6	-3.4	-0.5	-1.4	-2.2	-2.4	-1.4	-3.9	-1.1	0.4
Leg fat-free mass (left)	0.6	3.2	8.9	2.8	2.1	2.0	3.0	-1.4	-0.6	0.6	2.3	-0.3	1.9	-0.9	0.9
Trunk fat percentage	0.5	2.1	4.8	1.7	1.6	1.8	2.2	-1.7	-1.4	0.2	1.3	-0.3	0.6	-1.4	1.7
Hand grip strength (right)	0.8	2.3	6.4	-0.9	1.0	0.4	-0.2	-1.6	-1.7	-2.4	1.0	-2.5	-0.7	-2.1	1.6
Townsend deprivation index at recruitment	0.2	0.3	1.0	0.5	0.4	0.0	0.9	0.3	0.4	0.7	-0.1	0.6	-0.0	0.6	-1.0
Current tobacco smoking	0.6	1.0	2.6	-1.2	-1.4	-0.8	-0.5	1.0	0.8	-1.6	-0.6	-0.2	-0.7	0.5	-1.6
Average weekly fortified wine intake	1.0	1.2	3.1	-0.7	-1.7	-0.5	-1.4	-0.5	-0.9	-0.7	-1.8	-0.9	-1.2	-0.9	0.8
Maternal smoking around birth	0.1	0.2	0.5	-0.7	-0.2	0.1	-0.1	0.3	0.5	-0.5	-0.7	0.4	-0.4	0.4	0.1
Fed-up feelings	0.6	1.0	3.4	1.0	0.8	1.9	1.1	-0.2	-0.1	-0.5	1.5	-0.6	-0.1	-0.6	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	3.2	1.1	-0.7	0.1	-0.5	-1.2	-0.8	-1.7	-0.3	-1.8	-0.4	-1.2	0.9
Relative age voice broke	0.7	1.1	4.5	0.3	1.5	0.3	0.3	1.1	1.2	1.1	0.6	2.1	-0.5	1.1	-0.0
Taking other prescription medications	2.2	3.4	8.4	0.5	1.6	1.5	1.2	-2.3	-2.6	-1.5	1.8	-1.5	0.2	-2.9	2.4
Age when periods started (menarche)	0.9	2.2	5.6	-0.0	-1.0	-1.0	-1.0	2.3	2.4	1.2	-0.2	2.0	0.7	2.1	-1.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	2.4	-1.0	1.5	0.1	-0.0	0.1	-0.4	0.5	0.2	-0.0	-0.3	-0.4	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	5.4	-2.1	-0.7	-0.0	-0.5	-0.8	-1.1	-1.1	-1.4	-1.6	-2.3	-0.6	0.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.7	-0.7	-0.0	-0.7	-0.6	0.4	-0.5	0.7	-1.3	-0.1	-0.3	-0.1	-0.5
Qualifications: CSEs or equivalent	0.2	0.3	1.1	0.2	-0.5	-0.5	0.1	0.5	-0.4	0.7	-0.1	-0.1	1.0	0.1	-0.9
Serious illness, injury or assault to yourself	0.6	0.8	2.9	0.6	0.2	-0.2	-0.7	-0.8	-1.7	-0.1	0.1	-1.2	1.1	-1.4	0.1
High blood pressure	0.5	1.5	7.1	-0.1	2.3	0.7	2.7	0.1	-0.3	0.1	1.8	0.3	0.6	-0.4	0.9
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.8	-0.5	1.3	1.3	1.0	-0.5	-0.3	-0.2	1.2	0.5	-0.3	-0.9	1.1
Multivitamins +/- minerals	1.0	1.2	3.7	0.3	1.6	1.9	1.9	0.2	-0.2	0.6	1.8	0.7	0.3	-0.3	0.8
Stomach or abdominal pain in last month	0.5	0.6	3.0	0.2	-1.2	-0.9	-0.9	0.0	-0.2	0.3	-1.7	-0.4	1.1	-0.3	0.5
Supplements: Glucosamine	0.4	0.5	2.8	0.8	0.3	0.3	-0.3	0.3	-0.3	1.3	0.5	-0.3	1.7	-0.1	0.6
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	5.6	-1.4	1.4	1.8	0.3	-2.0	-1.7	-1.6	0.2	-1.0	-1.9	-1.8	2.4
Medication: Atenolol	0.4	0.5	1.3	-0.5	0.6	0.7	0.3	-0.9	-0.1	-0.7	0.1	-1.0	-1.1	-0.3	1.1
Medication: Levothyroxine sodium	1.2	2.0	5.2	-1.0	1.5	0.5	0.7	-2.1	-2.3	-0.8	1.0	-1.8	-0.6	-1.8	1.4
Sitting height	1.0	6.8	14.4	-1.9	2.6	2.0	1.1	-3.6	-3.3	-2.0	2.1	-2.5	-1.2	-3.8	3.2
Chronic bronchitis/emphysema (father)	0.4	0.5	2.0	1.4	-0.7	0.3	0.2	0.1	0.8	0.8	0.6	0.3	0.4	0.9	0.1
High blood pressure (mother)	0.9	1.2	2.8	1.6	0.0	0.6	-0.1	-1.7	-1.5	0.2	0.0	-1.1	1.1	-1.5	1.4
Body mass index (BMI)	1.0	4.1	12.0	3.5	1.9	1.8	3.3	-1.0	-0.9	1.6	1.8	0.4	3.2	-0.9	1.0
Impedance of leg (left)	0.9	4.5	19.5	-4.4	-0.6	-0.8	-2.4	-1.2	-1.5	-2.2	-1.3	-0.9	-3.7	-1.4	1.2
Leg predicted mass (left)	0.6	3.0	8.2	2.7	2.0	2.0	2.9	-1.4	-0.7	0.5	2.1	-0.3	1.8	-1.0	0.9
Trunk fat mass	0.8	3.4	8.6	1.9	2.1	2.4	2.9	-2.1	-1.5	0.3	2.0	-0.3	1.0	-1.7	2.0
Waist circumference	0.9	3.3	8.2	1.3	2.2	2.3	2.9	-2.2	-1.8	0.0	1.9	-0.2	0.5	-1.8	2.1
Number of incorrect matches in round	0.5	0.8	2.5	-0.7	1.5	1.0	1.3	-0.3	-0.0	-0.3	1.0	0.4	-1.6	-0.2	0.6
Past tobacco smoking	0.3	0.6	2.8	-0.1	0.1	-1.3	-1.5	0.0	-0.5	0.2	-1.7	-0.3	0.3	0.0	-0.3
Alcohol usually taken with meals	2.7	4.3	11.7	-1.8	-0.1	0.3	-1.3	-1.4	-2.3	-3.4	-0.1	-3.2	-2.6	-2.7	1.8
Nervous feelings	0.5	0.9	2.7	0.2	0.6	-0.6	0.7	1.0	1.6	1.1	0.5	1.4	-0.1	1.7	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	0.8	-0.6	-0.7	-0.7	0.5	0.8	-0.5	-0.2	-0.4	-0.2	0.5	-0.8
Hearing difficulty/problems with background noise	0.2	0.3	1.7	0.6	-0.4	0.4	0.2	-0.4	-0.4	-0.1	0.3	0.0	1.3	-0.4	0.3
Hair/balding pattern: Pattern 2	1.8	2.3	8.8	0.1	-0.1	1.7	0.2	-1.6	-1.8	-3.0	0.7	-1.9	-0.5	-2.0	1.3
Had menopause	1.2	1.6	5.3	-0.3	1.4	1.6	1.8	-0.8	-1.0	-0.4	2.3	-0.0	0.6	-1.4	1.3
Had other major operations	1.1	1.4	5.0	0.1	1.1	2.0	0.8	-1.5	-0.8	0.3	1.3	-0.0	-0.3	-0.9	2.2
Forced vital capacity (FVC)	0.2	0.9	4.5	0.2	-0.1	0.1	-0.5	-2.1	-1.2	-0.2	0.2	-0.7	0.7	-1.2	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	4.2	-1.6	0.4	0.7	0.4	-0.8	-1.4	-1.0	-0.3	-1.3	-2.0	-0.8	1.0
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.7	-1.7	1.0	0.1	0.2	-1.0	-1.5	-0.9	0.9	-1.5	-0.8	-1.3	1.2
Qualifications: None of the above	0.4	0.9	3.0	-1.7	-0.6	-1.5	-0.5	0.3	-0.3	-0.2	-1.6	-0.8	-0.2	0.2	-1.1
Financial difficulties in last 2 years	0.1	0.2	0.6	-0.5	0.1	-0.8	-0.3	0.3	0.4	0.7	-0.6	0.2	0.1	0.4	-0.1
Mouth/teeth dental problems	0.6	0.9	3.4	0.1	1.4	1.2	1.8	0.2	-0.0	0.7	1.0	0.9	-1.1	0.4	0.6
Heart attack	1.1	1.4	5.4	-2.3	-0.0	-1.5	-1.1	0.9	0.1	-1.3	-0.6	-1.0	-1.6	0.1	-1.3
Allergy	0.2	0.4	2.1	0.5	-1.4	-0.7	-0.5	0.4	0.0	0.1	-0.6	-0.3	0.4	0.7	-1.0
Pain all over the body in last month	0.3	0.3	1.0	-0.0	-0.8	0.5	-0.2	-1.0	-0.4	-1.0	-0.5	-0.1	-0.1	-0.5	0.7
Diabetes (self-reported)	0.4	0.6	1.9	-1.2	1.0	1.1	0.7	-0.4	-0.5	-0.4	1.4	0.3	0.7	-0.6	0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	0.8	-0.2	0.6	-0.0	-0.1	-0.1	0.3	0.4	0.6	0.6	-0.8	0.9
Medication: Ramipril	0.4	0.5	1.5	0.3	0.7	0.2	1.2	1.2	0.8	0.2	1.1	0.0	0.7	0.7	-0.3
Medication: Simvastatin	0.2	0.3	1.0	0.2	0.6	0.3	1.0	-0.1	0.1	1.0	0.7	0.7	-0.4	0.4	0.4
Fluid intelligence score	1.0	2.0	4.1	-1.5	0.4	1.8	0.0	-2.0	-1.6	-1.6	1.0	-1.3	-1.2	-1.5	1.5
Illnesses of siblings	1.5	2.1	6.4	-0.7	-1.2	-0.9	-2.5	-1.4	-1.8	-1.6	-1.8	-1.6	-0.7	-1.5	0.5
Neuroticism score	0.3	0.6	2.3	0.9	0.7	0.8	1.2	-0.2	-0.1	0.3	1.5	0.3	0.8	-0.2	0.7
Weight	1.0	4.9	12.8	2.6	2.7	2.6	3.6	-2.2	-1.5	0.6	2.6	-0.2	1.9	-1.7	1.8
Impedance of arm (right)	0.6	2.9	11.1	-2.4	-1.7	-1.6	-3.3	0.6	0.3	-0.6	-2.1	-0.3	-2.6	0.4	-0.4
Arm fat percentage (right)	0.5	2.1	8.3	2.9	0.9	1.4	2.2	-1.0	-0.7	1.4	1.0	0.3	2.0	-0.6	1.0
Trunk fat-free mass	0.6	3.4	6.9	1.2	2.0	2.3	2.4	-2.6	-1.8	-0.4	2.2	-0.9	1.1	-2.1	1.7
Hip circumference	1.2	5.1	12.9	3.6	3.1	2.0	3.1	-1.6	-1.2	0.6	2.5	-0.0	3.1	-1.5	1.5
Time employed in main current job	0.2	0.3	0.7	0.8	0.4	0.8	0.5	0.6	0.6	-0.2	0.6	-0.3	-0.2	0.3	0.6
Alcohol intake versus 10 years previously	0.6	0.9	1.8	0.3	0.6	-1.1	0.9	0.7	1.3	0.8	0.6	1.2	1.3	1.0	-0.9
Father’s age at death	0.8	1.1	5.5	-0.3	-0.8	-1.7	-2.3	-0.4	-0.1	-0.1	-2.0	-0.1	-0.1	0.2	-0.2
Worrier / anxious feelings	0.9	1.7	4.0	0.5	-0.5	-1.0	0.0	1.7	2.0	1.1	0.1	2.0	1.0	2.0	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.4	0.7	0.0	0.3	-0.5	-1.2	-0.5	-1.0	-0.2	-1.0	-0.7	-0.7	0.7
Falls in the last year	0.4	0.6	1.8	-1.4	-0.8	0.8	-0.5	-1.0	-0.6	-0.8	-0.7	-0.5	-0.7	-0.2	-0.3
Hair/balding pattern: Pattern 3	3.6	5.3	12.1	1.1	-0.8	-2.0	-0.9	2.8	3.1	3.0	-1.5	2.6	1.4	3.5	-2.7
Number of live births	0.3	0.4	1.4	-1.2	-1.1	-0.2	-0.4	0.2	-0.0	-0.9	-1.0	0.0	-0.2	-0.3	0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	4.1	1.8	-1.0	-0.2	-0.6	-1.6	-0.8	0.9	-0.3	-0.2	2.0	-0.6	0.7
Pulse rate	0.2	0.3	0.9	0.1	0.2	0.8	0.8	-0.6	-0.4	0.6	0.5	0.2	0.5	-0.4	0.9
Happiness	1.7	2.0	5.8	0.2	0.1	1.4	0.7	-1.9	-1.9	-1.5	1.4	-1.2	0.2	-2.4	1.8
Noisy workplace	0.3	0.4	1.1	-0.1	-0.2	-0.9	0.7	1.0	0.9	-0.5	-0.3	-0.4	0.1	0.6	-1.0
Qualifications: A levels/AS levels or equivalent	0.1	0.2	1.0	-0.5	-0.1	0.4	-0.0	1.0	0.2	-0.5	0.5	0.1	-1.0	0.1	-0.1
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.1	1.6	-0.9	-1.8	-0.8	1.6	1.0	0.5	-0.9	0.6	1.2	1.0	-1.4
Mouth/teeth dental problems: Dentures	0.5	0.8	4.2	-0.1	-1.3	-0.7	-0.3	-0.5	-1.0	-0.3	-0.2	-0.6	2.0	-1.1	-0.1
Asthma	0.1	0.2	0.5	-0.6	0.5	-0.7	0.2	-0.0	0.0	-0.0	-0.1	0.3	0.7	-0.2	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.5	0.0	0.8	0.4	0.3	-1.0	-0.7	-0.5	0.2	-1.2	-0.9	-0.3	0.5
Medication: Cholesterol lowering	0.2	0.3	2.2	-0.3	-0.2	0.1	0.6	0.0	0.3	-0.6	0.5	0.2	-1.5	0.3	0.2
Depression (self-reported)	0.1	0.2	0.5	0.3	-0.3	-0.1	-0.6	0.6	-0.2	-0.3	0.5	-0.2	0.7	-0.3	-0.0
Medication: Lansoprazole	4.3	4.9	11.6	-0.7	1.6	2.3	2.1	-3.4	-3.0	-0.9	1.9	-1.3	-0.5	-3.2	3.1
Prospective memory result	0.9	1.1	5.9	0.6	0.4	-0.4	0.3	1.0	1.0	1.2	0.3	1.4	2.4	1.0	-0.6
Lung cancer (father)	1.3	1.6	5.6	-0.3	-1.1	0.0	0.9	2.4	2.0	-0.3	0.0	1.4	-1.2	1.7	-0.9
Illnesses of mother	0.5	0.6	1.4	-0.8	1.2	-0.3	0.0	1.1	1.0	-0.1	0.2	0.9	-1.0	0.9	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	3.6	1.9	-0.7	-0.5	-0.7	-1.2	-0.4	0.2	-0.5	-0.5	1.1	-0.4	0.3
Pulse wave Arterial Stiffness index	1.0	1.1	2.8	-0.9	1.4	0.2	0.1	-0.9	-1.1	-1.4	1.0	-0.9	-1.7	-1.1	0.9
Impedance of arm (left)	0.8	3.7	12.1	-2.3	-2.0	-1.9	-3.5	1.0	0.6	-0.9	-2.6	-0.4	-3.0	0.8	-0.9
Arm fat mass (right)	0.8	3.5	9.8	2.9	1.8	2.0	3.1	-1.3	-1.0	1.2	1.9	0.2	2.4	-1.1	1.4
Trunk predicted mass	0.6	3.3	6.6	1.1	1.9	2.3	2.4	-2.6	-1.8	-0.3	2.2	-0.9	1.1	-2.1	1.7
Standing height	0.4	4.2	8.9	-1.8	2.1	1.9	0.8	-3.0	-2.0	-2.0	1.9	-1.4	-2.3	-2.5	2.2
Length of working week for main job	2.7	3.0	9.4	1.8	1.6	0.5	2.2	0.7	1.1	3.1	1.4	1.9	2.5	1.5	-0.7
Exposure to tobacco smoke at home	0.3	0.4	1.3	-0.1	-0.4	0.1	-0.3	-0.8	-1.1	0.3	-0.8	-0.7	0.2	-1.0	0.5
Breastfed as a baby	1.9	2.3	4.8	-1.3	-0.9	0.3	-1.1	-2.2	-2.2	-1.7	-1.1	-1.4	-0.6	-2.0	2.0
Tense / ‘highly strung’	1.0	1.7	3.6	1.3	1.3	0.7	1.8	1.3	1.6	1.0	1.4	1.9	0.2	1.2	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.8	-0.8	-1.1	-0.4	-1.0	-1.1	-1.7	-0.9	-0.5	-1.4	0.9	-1.5	1.0
Hair/balding pattern: Pattern 4	0.2	0.5	2.2	-0.2	0.4	0.3	0.6	-1.3	-0.1	-0.5	0.8	0.2	-0.4	-0.6	1.5
Birth weight of first child	0.5	0.9	2.5	0.2	0.9	1.5	0.6	-0.3	-1.0	-0.7	1.6	-0.9	-0.3	-1.2	1.2
Peak expiratory flow (PEF)	0.4	0.9	2.3	0.9	-0.3	-0.3	-1.5	-1.4	-1.0	-0.6	-0.5	-1.1	0.8	-1.0	0.9
Pulse wave reflection index	1.3	1.6	3.6	-0.7	1.9	0.5	0.4	-1.1	-1.6	-1.4	1.2	-0.9	-0.7	-1.7	1.8
Ever highly irritable/argumentative for 2 days	0.5	0.6	3.9	1.3	-0.7	-0.0	0.3	-0.3	0.2	1.0	0.2	0.2	2.0	-0.1	-0.2
Loud music exposure frequency	3.1	3.4	10.0	-1.0	2.2	2.6	3.2	-1.5	-1.7	-0.7	2.4	-0.5	-0.5	-1.7	1.9
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	1.0	0.5	0.6	0.2	0.2	-0.1	-0.2	-0.7	1.0	-0.1	0.5	-0.4	-0.2
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	5.2	-0.4	-0.6	-1.6	-2.3	0.2	0.7	-0.1	-1.3	-0.1	0.3	0.5	-0.8
Blood clot in the leg (DVT)	0.3	0.3	1.2	1.0	-0.1	-0.4	-0.9	-0.2	0.3	0.2	-1.1	-0.1	0.0	0.1	0.8
Medication: Paracetamol	0.7	1.2	2.5	0.9	-1.4	-1.6	-1.5	1.2	1.0	-0.6	-1.5	0.1	0.3	0.7	-1.1
Headache pain in last month	0.9	1.6	4.0	-2.0	0.1	0.2	-0.8	-1.8	-1.6	-1.2	-1.2	-0.8	-1.1	-1.5	1.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.6	-0.1	-0.2	0.1	-0.8	-0.5	-0.1	0.3	-0.7	0.2	-0.0	-0.1	0.1
Glaucoma (self-reported)	1.8	2.2	5.2	-1.2	1.8	2.1	2.0	-1.3	-0.8	-0.5	2.3	0.2	-1.4	-0.9	1.5
Gout (self-reported)	0.3	0.3	1.6	0.7	-0.1	-0.7	-0.3	1.3	0.6	-0.4	-0.5	-0.4	0.1	0.3	-0.6
Hypothyroidism/myxoedema (self-reported)	2.7	5.3	11.8	-1.2	1.8	1.4	0.6	-3.1	-3.4	-2.6	1.4	-3.4	-1.6	-3.1	1.8
Medication: Amlodipine	0.5	0.7	2.3	-0.6	1.5	0.3	1.5	0.7	-0.2	-0.1	1.5	0.3	0.4	-0.1	0.7
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.6	-0.7	1.2	0.5	1.1	-0.1	0.8	0.9	0.9	1.3	0.3	0.5	0.6
Birth weight	0.7	1.5	5.0	0.3	-2.2	-0.8	-1.9	0.9	1.0	0.3	-0.5	0.3	2.0	0.9	-1.1
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.3	0.7	-0.8	-1.0	-0.6	0.5	0.2	0.1	-1.1	0.0	0.2	0.6	-0.7
High blood pressure (siblings)	0.7	1.0	5.6	0.4	1.5	0.9	2.4	0.3	-0.0	0.5	1.8	0.1	-0.2	0.0	0.3
Forced vital capacity (FVC), Best measure	0.2	0.9	4.5	0.6	0.5	0.4	-0.2	-2.1	-1.0	-0.6	0.4	-0.7	0.2	-1.1	1.3
Body fat percentage	0.6	2.2	4.8	1.8	1.5	1.9	2.2	-1.8	-1.4	0.1	1.2	-0.3	0.6	-1.5	1.8
Leg fat percentage (right)	0.4	1.5	2.9	1.6	0.9	1.5	1.7	-1.5	-1.4	0.2	0.6	-0.4	0.8	-1.3	1.4
Arm fat-free mass (right)	0.9	4.7	11.6	2.0	2.8	2.5	3.4	-2.3	-1.6	-0.1	2.8	-0.6	1.5	-2.0	2.0
Exposure to tobacco smoke outside home	0.3	0.3	1.3	1.0	-0.6	-0.4	0.2	-0.4	0.0	-0.2	-0.3	-0.9	0.4	0.2	-1.1
Comparative body size at age 10	0.4	1.0	3.5	1.4	1.5	0.3	1.9	-0.0	-0.1	1.4	0.8	0.1	1.2	0.2	-0.6
Number of full brothers	0.6	0.8	2.5	0.4	-0.9	0.1	0.9	1.6	0.8	1.0	-0.2	1.1	0.3	1.1	-1.0
Worry too long after embarrassment	0.7	1.2	3.0	0.0	1.2	0.7	1.3	-1.5	-1.2	0.8	1.1	0.4	1.0	-1.0	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.1	0.1	0.5	0.2	-0.0	-1.1	-1.4	-0.7	0.7	-1.3	0.7	-1.5	0.5
Wheeze or whistling in the chest in last year	0.9	1.5	3.3	-0.5	1.5	0.8	1.2	-1.3	-0.5	-1.8	1.7	-1.2	-1.5	-1.1	0.9
Number of children fathered	0.9	1.0	3.0	-0.9	0.7	0.9	0.7	-1.7	-1.2	-0.6	0.3	-0.5	-0.5	-1.2	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	3.6	-0.7	1.0	-0.8	1.0	1.5	0.9	-0.1	-0.3	0.2	-1.9	1.4	-0.7
Age at first live birth	0.2	0.4	0.9	-0.9	0.8	0.9	-0.5	-0.5	-0.6	-0.6	0.3	-0.1	-0.8	-0.6	0.5
Pulse wave peak to peak time	0.5	0.5	1.9	0.9	-1.0	0.3	0.1	0.3	0.6	1.0	-0.5	0.5	1.4	0.6	-0.4
Health satisfaction	1.7	2.2	5.8	2.1	0.1	1.1	-0.2	-1.9	-2.0	-0.1	1.1	-1.0	2.4	-2.0	1.3
Shortness of breath walking on level ground	2.1	2.5	7.4	-1.0	0.1	1.2	0.7	-2.2	-2.6	-0.9	1.2	-1.4	1.1	-2.7	1.5
Qualifications: College or University degree	0.2	0.7	1.5	0.0	-0.9	0.8	-1.2	-0.6	-0.9	-1.0	-0.5	-1.0	-0.3	-1.0	1.0
Eye problems/disorders: None of the above	0.6	0.6	2.2	0.4	-1.0	0.1	0.2	0.8	1.0	1.5	-0.9	1.0	0.0	0.9	-0.2
Mouth/teeth dental problems: Loose teeth	1.7	2.0	5.9	-0.1	-2.3	-1.7	-2.1	1.1	0.6	-0.2	-1.5	-0.6	0.7	0.7	-2.4
Emphysema/chronic bronchitis	0.7	0.8	2.2	0.4	0.4	1.0	0.1	-1.3	-0.2	-1.4	0.8	-0.6	-1.5	-0.6	0.7
Medication for pain relief, constipation, heartburn	0.2	0.3	1.2	-1.1	-0.2	-0.1	-0.3	0.7	0.3	0.4	-0.2	-0.2	-0.3	0.5	-0.9
Neck or shoulder pain in last month	0.1	0.2	0.5	-0.4	-0.3	-0.6	-0.3	-0.5	-0.1	-0.6	-0.7	-0.4	-0.6	-0.2	-0.1
Medication: Blood pressure	0.3	0.5	1.7	-0.5	0.8	0.1	1.3	0.9	0.0	0.2	1.1	0.2	0.7	0.0	-0.2
Angina (self-reported)	0.8	1.0	5.2	-2.3	0.8	0.5	0.3	-0.9	-0.5	-0.5	0.6	-0.0	-1.8	-0.5	0.9
Migraine (self-reported)	0.5	0.6	3.5	-1.2	0.1	0.2	0.3	-0.2	0.7	-1.0	-0.3	-0.3	-1.9	0.3	0.8
Medication: Ibuprofen	1.2	1.5	4.2	-1.4	-0.3	-0.9	-1.3	-1.1	-1.4	-1.4	-1.3	-2.1	-1.0	-0.9	0.4
Medication: Allopurinol	0.1	0.2	1.3	1.1	0.3	0.2	0.5	0.4	-0.1	0.4	0.3	-0.1	-0.0	-0.1	0.1
Medication: Omeprazole	0.9	1.1	4.7	-0.2	0.2	0.8	0.4	-1.6	-1.6	0.1	0.4	-0.1	0.5	-1.6	2.2
Medication: Seretide 50 evohaler	1.4	1.6	4.0	1.4	2.0	1.7	1.2	-0.1	-0.0	1.3	1.5	1.0	1.6	0.1	1.2
Mean time to correctly identify matches	0.3	0.6	2.7	-0.8	0.8	-0.4	-0.9	0.3	1.0	-1.6	-0.2	-0.8	-0.4	0.4	-0.3
Heart disease (mother)	2.0	2.4	7.2	1.2	-0.6	-0.4	0.7	1.3	1.8	2.7	-0.1	2.2	1.8	2.3	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	5.2	-0.8	-2.2	-2.2	-2.3	0.4	-0.6	0.1	-1.8	0.1	1.3	-0.2	-1.7
Whole body fat mass	0.8	3.4	8.8	1.9	2.2	2.3	3.0	-2.0	-1.5	0.3	2.0	-0.2	1.2	-1.7	2.0
Leg fat mass (right)	0.8	2.9	7.3	1.9	1.9	2.0	2.7	-1.9	-1.5	0.2	1.7	-0.4	1.1	-1.7	1.8
Arm predicted mass (right)	0.9	4.5	11.1	1.9	2.7	2.6	3.3	-2.3	-1.7	-0.4	2.8	-0.8	1.2	-2.1	1.8
Pulse rate, automated reading	0.1	0.3	0.8	0.3	-0.6	0.1	-0.1	-0.9	-0.9	-0.2	-0.7	-0.3	0.1	-0.5	0.8
Alcohol intake frequency.	0.3	0.8	2.5	-0.1	-0.6	-1.2	-0.9	0.8	1.3	-0.2	-0.8	-0.7	0.3	0.8	-1.6
Comparative height size at age 10	0.6	3.2	8.8	-1.6	1.2	1.0	0.5	-2.2	-2.9	-2.0	1.0	-1.9	-0.8	-3.0	1.2
Number of full sisters	0.5	0.6	1.6	0.1	-0.7	0.1	0.9	0.1	0.9	1.2	-0.8	1.1	0.7	1.2	-0.3
Suffer from ‘nerves’	0.5	0.8	2.3	0.1	0.0	0.7	1.5	1.3	0.9	0.2	1.5	1.0	-0.9	0.8	-0.3
Overall health rating	0.3	0.7	2.5	0.7	1.6	0.8	1.2	-0.5	-0.2	-0.7	1.2	-0.2	0.6	-0.6	0.3
Chest pain or discomfort	1.9	2.8	7.6	-2.8	0.1	-0.5	-0.4	-2.0	-1.9	-1.8	-0.3	-1.9	-2.1	-1.9	1.7
Had major operations	0.3	0.4	1.3	0.2	0.7	1.1	0.1	-1.0	-0.1	-0.7	0.9	0.3	-0.0	-0.8	0.5
Age at last live birth	0.4	0.5	2.3	-1.4	0.1	0.2	-0.6	0.8	0.4	-0.5	-0.3	0.3	-1.5	0.3	-0.6
Family relationship satisfaction	0.4	0.5	1.7	1.1	-1.0	-0.1	-1.3	-0.0	-0.4	-0.9	-0.2	-1.0	0.3	-0.6	-0.2
Leg pain on walking	0.8	1.0	2.6	-0.4	-0.2	-0.2	-0.7	-0.4	-1.4	-1.6	-0.1	-1.6	1.1	-1.6	0.2
Qualifications: NVQ or HND or HNC or equivalent	2.7	3.3	7.4	1.8	2.0	2.7	2.3	-1.0	-0.2	1.9	2.5	1.4	2.0	-0.4	1.4
Commuting to job workplace: Car/motor vehicle	0.7	0.9	2.7	1.1	-0.1	0.5	0.3	0.1	1.0	1.2	0.8	1.7	1.5	0.5	-0.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.8	-0.2	1.3	1.2	1.1	-0.5	-0.9	-0.2	1.0	0.2	-0.2	-0.7	1.3
Medication: Aspirin	0.7	1.0	2.2	-0.2	0.6	1.2	1.2	-1.0	-0.8	-0.7	1.5	-0.3	-1.1	-0.9	1.5
Supplements: Vitamin C	0.1	0.1	0.6	0.3	-0.2	-0.0	0.0	0.7	0.1	0.3	-0.0	0.8	0.2	0.2	-0.2
Knee pain experienced in last month	0.3	0.5	3.3	0.8	-0.0	-0.5	-0.1	-0.2	-0.8	-0.1	0.2	-0.3	1.8	-0.9	-0.1
Hypertension (Self-reported)	0.6	1.8	8.4	0.0	2.4	1.1	2.9	0.3	0.0	0.3	2.1	0.5	0.6	-0.2	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.7	3.2	9.1	-1.5	2.1	1.7	2.2	-1.8	-1.9	0.1	1.6	0.8	-0.8	-1.9	3.0
Illnesses of father: Heart disease	1.3	1.9	5.4	0.6	-0.0	-1.1	0.1	1.6	2.3	1.1	-0.3	1.7	0.6	2.1	-2.0
Illnesses of siblings: Diabetes	0.3	0.4	1.0	-0.1	0.3	0.1	0.5	0.6	0.4	0.8	0.8	0.8	1.0	0.5	-0.6
Smoking status: Previous	0.2	0.3	1.1	-0.0	-0.2	0.5	0.9	0.3	0.6	0.2	1.0	0.5	0.5	0.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.8	0.3	0.3	1.3	0.6	-1.9	-0.8	0.6	-0.0	0.4	-0.1	-0.8	1.6
Whole body fat-free mass	0.6	3.5	8.2	1.9	2.2	2.3	2.9	-2.2	-1.3	-0.1	2.5	-0.7	1.5	-1.7	1.5
Leg fat-free mass (right)	0.7	4.0	11.5	2.9	2.3	2.4	3.4	-1.6	-0.5	0.7	2.8	0.0	2.0	-0.9	1.1
Arm fat percentage (left)	0.6	2.4	10.9	3.3	1.0	1.5	2.3	-0.8	-0.5	1.3	1.0	0.4	2.0	-0.4	0.9
Average weekly red wine intake	0.3	0.4	1.9	-0.6	0.3	0.5	0.2	0.6	0.8	-0.9	0.2	0.2	-1.4	0.6	-0.4
Handedness (chirality/laterality): Left-handed	1.4	1.7	4.4	-0.7	-1.3	-2.1	-2.1	1.3	1.1	0.3	-2.0	0.5	-0.1	1.2	-0.7
Mood swings	0.3	0.5	1.7	0.6	-0.5	-0.5	-0.6	-0.5	-0.6	-1.0	-0.4	-1.3	0.6	-0.7	0.8
Loneliness, isolation	0.5	0.7	3.0	1.0	-0.4	-0.2	-0.4	-0.7	-1.3	-0.9	0.0	-1.7	0.2	-1.2	-0.2
Long-standing illness, disability or infirmity	1.1	1.7	4.8	-0.8	0.0	0.2	-0.2	-1.7	-2.1	-2.1	0.2	-1.6	0.4	-2.2	1.0
Ever had bowel cancer screening	0.7	0.9	2.7	-1.6	0.1	-0.4	-0.7	-0.6	-1.0	-1.4	0.4	-1.2	-0.4	-1.1	0.7
Diabetes diagnosed by doctor	0.2	0.4	1.7	-1.3	0.4	0.8	0.1	-0.6	-0.4	-0.8	0.8	0.1	-0.3	-0.4	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.4	0.1	-0.3	0.2	0.1	-0.1	-0.4	0.3	-0.1	-0.6	0.2	-0.2	0.1
Friendships satisfaction	0.6	0.7	3.0	0.5	0.3	0.8	0.0	-0.6	-0.9	-0.7	1.6	-0.3	1.7	-0.9	0.4
Qualifications: nursing, teaching	0.3	0.5	1.9	0.8	0.2	1.3	0.3	-0.7	0.0	0.2	0.8	0.5	0.2	-0.6	1.4
Commuting to job workplace: Walk	0.5	0.5	1.8	-0.7	-0.1	-0.2	0.1	0.4	0.9	-0.7	-0.3	-0.1	-1.3	1.1	-1.1
Eye problems/disorders: Cataract	0.5	0.6	3.2	0.2	1.0	-0.7	-0.5	0.8	0.2	-1.8	0.4	-0.7	-0.7	0.0	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.3	0.2	0.4	1.3	0.5	0.8	0.6	0.7	1.5	0.5	0.0	-0.0	0.2
Medication for cholesterol	0.5	0.7	1.9	0.9	-1.1	-0.5	-1.4	0.9	0.9	-0.5	-0.5	0.1	-0.5	0.9	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	3.6	-1.8	-0.1	0.4	0.3	-1.2	-1.7	-1.5	-0.1	-1.9	-1.2	-1.7	1.1
Back pain experienced in last month	0.4	0.6	1.5	0.4	0.8	1.0	1.2	-0.3	-0.0	0.4	1.0	1.0	1.2	-0.2	0.6
Mineral and other dietary supplements	2.1	2.9	7.3	-1.2	-0.8	-0.9	-1.6	-1.9	-1.4	-2.7	-1.4	-2.2	-1.9	-1.9	1.3
Breast cancer (self-reported)	1.5	1.8	5.5	2.4	-1.4	-0.3	-0.3	1.0	0.8	1.4	0.0	0.9	2.1	1.3	-1.9
Asthma (self-reported)	0.1	0.2	0.6	-0.6	0.7	-0.8	0.3	0.3	0.3	0.0	0.2	0.5	0.7	0.0	0.0
Osteoporosis (self-reported)	1.2	1.4	5.5	-1.4	0.2	0.8	-0.2	0.2	-0.6	-2.3	0.6	-1.2	-2.3	-1.0	0.8
Osteoarthritis (self-reported)	0.9	1.2	6.6	0.6	-1.7	-0.7	-0.9	-0.4	-1.0	0.0	-1.0	-0.4	2.6	-0.7	-0.4
Medication: Aspirin	0.4	0.5	1.1	-0.6	0.2	0.7	0.9	-0.7	-0.6	-0.4	0.9	0.0	-1.0	-0.5	0.9
Medication: Gliclazide	0.8	0.9	4.8	-2.2	-0.2	-0.7	-0.7	-0.6	-0.9	-0.9	-1.1	-0.6	0.4	-1.1	0.6
Illnesses of father: None of the above (group 1)	0.9	1.2	3.5	0.9	-0.9	0.7	-0.8	-0.5	-1.1	-1.7	-0.4	-1.9	-0.6	-1.5	0.8
Smoking status: Current	0.5	0.8	2.8	-1.2	-1.2	-0.5	-0.2	0.7	0.6	-1.7	-0.4	-0.4	-1.0	0.3	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	3.9	0.5	-0.2	0.1	-0.3	-1.3	-0.9	0.0	-0.4	-0.7	0.1	-0.9	2.0
Whole body water mass	0.6	3.6	8.9	1.9	2.3	2.4	3.0	-2.1	-1.3	0.0	2.5	-0.5	1.5	-1.6	1.5
Leg predicted mass (right)	0.8	4.0	11.5	2.9	2.3	2.4	3.4	-1.6	-0.5	0.6	2.8	0.0	2.0	-0.9	1.1
Arm fat mass (left)	0.9	3.9	10.0	3.2	1.9	2.2	3.1	-1.4	-1.0	1.3	1.9	0.3	2.4	-1.0	1.4
Number of self-reported non-cancer illnesses	0.7	1.2	2.8	0.0	1.0	0.8	1.2	-1.0	-1.0	-1.6	0.9	-0.8	-0.5	-1.7	1.5
Average weekly champagne plus white wine intake	2.4	3.4	8.2	0.1	0.5	1.6	-0.2	-2.8	-2.6	-1.6	1.1	-2.3	-0.8	-2.9	2.2
Miserableness	0.6	1.1	3.0	-0.7	0.2	0.3	-0.2	-1.2	-1.1	-1.7	0.6	-1.7	-0.4	-1.4	1.3
Guilty feelings	0.3	0.5	1.2	1.0	0.6	1.0	0.6	-1.1	0.0	0.1	1.0	-0.1	-0.1	-0.2	1.1
Wears glasses or contact lenses	1.3	1.5	4.8	-1.0	0.4	-0.1	-1.4	-1.3	-0.9	-1.5	-0.6	-1.5	-2.2	-1.0	1.6
Ever taken oral contraceptive pill	1.1	1.2	6.5	2.5	-0.6	0.1	-0.5	-1.4	-0.5	1.0	-0.5	0.1	1.9	-0.2	0.4
Hearing aid user	0.9	1.0	2.6	-0.5	-0.5	0.4	-0.7	-1.3	-1.6	-0.5	-0.4	-0.9	0.9	-1.5	1.5
Mother’s age at death	0.2	0.3	1.0	0.2	-0.6	-0.2	-1.0	0.3	0.1	-0.8	0.8	0.1	0.6	-0.3	-0.1
Financial situation satisfaction	0.8	0.9	3.1	0.5	0.1	0.4	-0.1	-1.2	-1.8	0.0	0.5	-1.6	0.9	-1.5	0.5
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.4	0.1	0.6	0.3	1.2	0.2	0.0	0.1	1.0	-0.3	1.2	-0.1	0.0
Commuting to job workplace: Public transport	0.5	0.6	2.1	-0.1	-0.2	0.4	-0.7	-1.4	-1.1	-0.1	-0.4	-0.5	-0.7	-0.9	1.2
Eye problems/disorders: Glaucoma	1.8	2.1	4.6	-1.0	1.8	1.8	1.7	-1.3	-1.5	-0.4	2.1	0.2	-0.8	-1.4	1.9
Medication: Blood pressure	0.7	1.4	6.0	-0.9	2.4	0.7	2.2	-0.0	-0.9	0.3	1.1	-0.2	0.7	-0.8	0.9
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.2	-0.6	-0.0	-0.6	-0.1	0.2	0.1	-1.5	0.4	-0.7	-0.7	-0.3	-1.4
Supplements: Fish oil (including cod liver oil)	2.7	3.6	6.5	1.6	0.8	0.6	1.3	2.5	2.2	2.1	1.4	2.2	2.6	2.3	-2.0
High cholesterol (Self-reported)	0.6	1.0	4.8	-0.1	0.7	1.3	2.2	-0.9	-0.4	0.8	1.4	0.8	0.3	-0.2	0.9
Medication: Bendroflumethiazide	0.8	1.2	4.5	-0.9	2.1	0.6	1.9	-0.6	-1.0	0.1	1.4	-0.2	0.6	-0.8	1.0
Medication: Paracetamol	0.9	1.3	3.7	0.6	-1.7	-1.9	-1.9	0.7	0.3	-0.4	-1.7	-0.4	1.2	0.3	-0.6
Medication: Lisinopril	1.3	1.7	5.0	0.2	1.3	1.1	1.5	-1.3	-2.2	-0.2	0.8	-0.7	1.1	-2.0	1.5
Medication: Atorvastatin	2.9	3.6	6.7	-1.6	0.4	2.1	0.5	-2.1	-2.4	-2.2	1.1	-2.1	-1.7	-2.6	2.4
Illnesses of father: High blood pressure	0.5	0.6	1.5	-1.2	1.1	-0.7	0.4	0.1	-0.4	0.8	-1.1	0.9	-1.0	0.1	0.6
Alcohol drinker status: Never	1.9	2.3	6.5	-0.9	-1.8	-1.9	-2.5	1.1	0.7	-0.7	-1.9	-0.9	-1.1	0.9	-2.2
Ever smoked	0.3	0.6	2.0	0.1	-0.2	0.8	1.1	0.7	1.3	-0.6	1.4	0.4	-0.7	0.6	-0.1
Basal metabolic rate	0.7	4.0	9.9	2.3	2.3	2.4	3.1	-2.2	-1.4	0.2	2.5	-0.5	1.8	-1.7	1.6
Leg fat percentage (left)	0.7	2.4	5.3	1.7	1.4	1.9	2.3	-1.9	-1.5	0.2	1.2	-0.2	1.2	-1.5	1.9
Arm fat-free mass (left)	1.1	5.5	13.8	1.9	2.9	2.8	3.7	-2.5	-1.8	0.0	3.1	-0.4	1.7	-2.2	2.2
Number of operations (self-reported)	0.2	0.3	0.7	-0.4	0.7	0.8	-0.1	-0.2	0.4	-0.5	0.7	0.1	-0.5	-0.3	0.8
Average weekly beer plus cider intake	0.8	1.1	2.9	0.8	1.2	0.7	1.4	0.5	1.2	1.4	0.5	1.7	0.9	1.1	-0.1
Irritability	1.2	2.0	5.9	-0.0	2.1	2.4	2.1	-0.4	0.3	0.8	2.4	0.9	-0.2	-0.2	1.4
Risk taking	0.4	0.6	1.5	0.3	0.9	1.1	1.2	-0.7	-0.5	0.7	1.1	0.3	0.9	-0.7	0.2
Ever had prostate specific antigen (PSA) test	2.3	2.7	5.2	-1.1	-1.6	-0.8	-2.2	-1.6	-1.4	-2.3	-1.9	-2.2	-1.7	-1.2	0.2
Fractured/broken bones in last 5 years	0.8	1.1	4.5	-1.5	-0.9	-0.5	-0.8	0.5	-0.2	-2.1	-1.0	-1.0	-1.2	-0.2	-0.7
Age started oral contraceptive pill	1.0	1.3	4.1	0.5	-0.6	-2.0	-1.3	1.6	0.8	0.7	-1.3	0.7	0.9	0.9	-1.2
Diastolic blood pressure, automated reading	0.6	2.0	4.6	2.0	1.4	-0.2	2.1	2.0	1.1	1.2	0.4	1.8	0.8	1.2	-0.6
Ever depressed for a whole week	0.9	1.2	3.6	-1.1	1.6	1.2	1.4	-0.2	-0.7	-0.0	1.9	0.1	-0.4	-0.8	1.4
Unable to work because of sickness or disability	1.6	2.1	6.0	1.9	1.3	2.0	2.2	-1.3	-0.5	0.0	2.4	-0.1	1.0	-1.1	1.0
Commuting to job workplace: Cycle	1.0	1.2	2.8	-0.1	-1.1	-1.6	-1.2	1.3	0.2	0.9	-1.7	-0.1	0.9	0.8	-1.5
Myopia	0.6	0.8	3.0	-0.5	1.4	1.2	1.2	-0.2	0.8	0.2	1.7	0.4	-0.8	0.5	0.3
Vascular/heart problems diagnosed by doctor	0.4	1.0	5.1	0.4	-1.9	-0.3	-2.3	-0.3	0.0	-0.0	-1.5	-0.2	-0.7	0.3	-0.5
Cholesterol lowering medication	1.7	2.5	5.0	-1.5	1.4	1.7	1.2	-2.1	-2.2	-0.4	1.4	-1.2	-0.3	-2.2	1.9
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	5.3	0.1	0.2	0.6	0.1	-2.1	-1.8	-0.1	-0.1	-0.3	0.1	-1.7	2.3
Pain experienced in last month	0.5	0.8	2.6	0.0	-0.1	0.3	-0.3	1.5	1.1	1.0	0.3	0.6	-0.8	1.6	-1.1
Supplements: Calcium	1.4	1.6	5.2	0.8	-0.2	0.1	0.5	2.3	1.7	1.3	0.2	1.7	0.2	2.0	-1.1
Basal cell carcinoma (self-reported)	0.6	0.7	2.5	-0.8	0.0	0.2	0.3	1.2	1.2	0.8	-0.2	1.2	-0.7	1.6	-0.4
Heart attack/myocardial infarction (self-reported)	1.2	1.5	4.7	-2.2	-0.2	-1.6	-1.2	1.0	0.3	-1.4	-0.7	-1.1	-1.7	0.2	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.6	0.7	-0.4	-0.5	-1.1	-0.1	0.1	-0.1	-1.3	-0.4	-0.1	-0.1	0.9
Heart disease (siblings)	1.8	2.2	6.6	-1.1	0.4	-0.1	1.5	1.9	2.6	0.5	0.7	2.0	-1.2	2.3	-1.0
Alcohol drinker status: Previous	0.1	0.2	0.4	-0.6	0.1	-0.2	0.0	0.4	0.6	-0.2	0.3	-0.1	0.6	0.2	-0.6
Pack years of smoking	0.6	0.9	2.4	1.1	0.3	-0.8	-0.9	-0.1	-0.8	-1.2	0.6	-1.5	1.6	-0.7	-0.2
Impedance of whole body	0.8	3.9	14.2	-3.5	-1.2	-1.4	-3.1	0.1	-0.5	-1.6	-2.0	-0.8	-3.8	-0.3	0.3
Leg fat mass (left)	1.0	3.9	9.9	2.2	2.4	2.3	3.1	-2.1	-1.5	0.3	2.2	-0.2	1.5	-1.7	2.1
Arm predicted mass (left)	0.9	4.7	12.0	1.9	2.8	2.5	3.5	-2.1	-1.6	0.1	2.9	-0.4	1.8	-1.9	1.9