Hub : Genes

TECPR1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.2029	0.0505	5.8e-06	0.053	NA	0.094	NA	0.093	5.2e-05	NA	8.4e-08	NA	8.8e-08
2	GTEx	Cells EBV-transformed lymphocytes	0.2310	0.0880	8.1e-04	0.054	NA	0.025	NA	0.040	7.6e-03	NA	5.1e-02	NA	1.9e-02
3	GTEx	Esophagus Mucosa	0.1480	0.0480	1.0e-05	0.150	NA	0.098	NA	0.114	3.0e-10	NA	4.4e-07	NA	5.1e-08
4	GTEx	Esophagus Muscularis	0.1680	0.0560	5.0e-04	0.080	NA	0.037	NA	0.052	1.4e-05	NA	2.5e-03	NA	4.0e-04
5	GTEx	Skin Not Sun Exposed Suprapubic	0.1300	0.0460	1.4e-04	0.008	NA	0.020	NA	0.029	1.1e-01	NA	2.6e-02	NA	1.0e-02
6	GTEx	Skin Sun Exposed Lower leg	0.1900	0.0470	1.2e-11	0.087	NA	0.187	NA	0.170	1.0e-07	NA	2.4e-15	NA	5.7e-14
7	GTEx	Thyroid	0.1170	0.0390	2.1e-04	0.052	NA	0.076	NA	0.104	7.1e-05	NA	1.8e-06	NA	2.4e-08
8	METSIM	Adipose	0.0773	0.0270	2.9e-05	0.036	0.045	0.054	0.047	0.044	4.0e-06	2.0e-07	1.3e-08	1.1e-07	3.2e-07
9	NTR	Blood	0.0442	0.0115	4.4e-16	0.066	0.053	0.064	0.064	0.065	1.7e-20	1.3e-16	6.7e-20	9.5e-20	4.0e-20
10	ROSMAP	Brain Pre-frontal Cortex	0.1627	0.0407	0.0e+00	0.247	0.173	0.241	0.222	0.245	1.9e-31	1.1e-21	1.4e-30	4.3e-28	3.2e-31
11	YFS	Blood	0.4275	0.0372	0.0e+00	0.519	0.517	0.533	0.528	0.536	4.2e-203	9.4e-202	8.6e-211	8.0e-208	7.8e-213
12	TCGA	Lung Adenocarcinoma	0.0393	0.0211	1.6e-04	0.029	0.021	0.017	NA	0.022	2.2e-04	1.4e-03	3.4e-03	NA	1.0e-03
13	TCGA	Thyroid Carcinoma	0.0230	0.0140	4.8e-03	0.007	0.011	0.010	NA	0.011	6.8e-02	2.8e-02	3.4e-02	NA	2.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	2.4	3.7	8.1	-0.1	-2.5	1.4	1.4	2.0	2.9	1.4	-1.0	2.3	2.1	2.2	1.9	2.2
Bipolar Disorder or Schizophrenia	0.6	1.5	3.7	1.9	-0.9	1.6	1.4	0.8	1.6	1.4	-1.3	0.4	-0.0	-0.0	1.0	1.5
Depressed Affect (Nagel 2018)	1.6	3.3	6.7	2.0	2.5	-0.9	-0.8	-1.8	-1.6	-0.4	0.7	-2.1	-2.0	-2.0	-2.6	-2.5
Depression (Nagel 2018)	0.4	0.6	1.9	0.3	1.4	-0.6	-0.4	-0.5	-0.2	0.1	0.9	-0.6	-0.6	-0.7	-1.1	-1.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.1	-1.1	-1.8	1.5	1.2	0.7	1.3	0.3	1.1	0.3	-0.1	0.1	1.0	0.7
Neuroticism (Nagel 2018)	4.9	11.4	24.3	2.6	4.1	-2.3	-1.9	-3.2	-3.7	-1.2	0.7	-3.7	-3.6	-3.8	-4.9	-4.9
Schizophrenia (2018)	0.6	1.3	5.6	2.4	0.8	0.8	0.6	-0.6	-0.2	0.6	-1.0	-1.3	-1.7	-1.8	-0.3	0.1
Schizophrenia vs Biploar Disorder	0.2	0.3	1.9	1.4	0.1	0.4	0.5	-0.0	0.1	0.1	0.0	-0.5	-0.8	-0.9	0.1	0.1
Worry (Nagel 2018)	6.2	13.0	25.3	1.3	4.4	-3.4	-2.8	-3.6	-4.9	-2.0	-0.1	-3.6	-3.4	-3.7	-5.0	-4.9
Alzheimer’s Disease (in mother)	0.3	0.3	1.1	0.1	-0.9	0.3	0.5	0.6	0.3	0.2	0.1	0.9	1.0	1.1	0.2	-0.1
Alzheimer’s Disease (in father)	1.4	1.5	3.3	1.1	-1.4	1.3	1.5	1.7	1.1	1.8	0.4	1.2	1.2	1.0	0.9	0.8
Alzheimer’s Disease (including proxy)	0.5	0.7	2.6	0.4	-1.6	0.5	0.7	0.9	0.6	0.2	0.3	1.0	1.2	1.2	0.4	0.0
Crohns Disease (2017)	0.4	0.9	6.9	-0.7	-2.6	0.1	-0.4	1.1	1.1	-0.1	-0.1	0.1	0.1	-0.0	1.1	1.0
Irritable Bowel Disease (IBD)	0.3	0.6	1.2	-0.6	-0.9	-0.6	-0.7	-0.4	-0.1	-1.0	-0.6	-0.9	-1.0	-1.1	-1.0	-0.8
Ulcerative Colitis (UC)	1.3	2.5	7.1	-0.2	1.4	-1.0	-0.9	-2.0	-1.6	-1.6	-0.8	-1.4	-1.7	-1.7	-2.7	-2.2
Major Depression (MDD)	0.1	0.1	0.3	0.5	0.1	-0.1	-0.0	0.1	0.3	0.2	-0.4	-0.4	-0.3	-0.2	-0.4	-0.6
Reaction Time	0.4	0.8	3.3	0.7	0.1	0.5	0.9	-0.6	-1.1	0.7	0.5	-0.4	-0.4	-0.3	-1.7	-1.8
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.5	-0.3	-1.3	1.9	1.9	1.1	1.7	1.3	0.9	0.6	0.4	0.5	0.9	0.9
Breast Cancer	2.7	6.4	14.9	-2.3	-3.9	-0.2	0.2	3.0	1.6	0.9	1.8	3.0	3.5	3.6	2.8	2.3
Ovarian Cancer	2.1	2.8	5.5	-0.1	-1.9	0.9	0.8	2.0	1.1	1.2	-0.5	2.1	2.4	2.4	2.2	2.0
Prostate Cancer	22.9	32.2	57.3	-1.1	-7.3	4.8	4.5	7.5	7.6	5.1	2.1	5.5	5.2	5.0	7.2	6.7
Age at First Birth	0.2	0.4	1.4	0.1	1.1	-0.2	-0.1	-0.2	-1.2	0.3	-0.7	-0.7	-0.7	-0.6	0.1	0.1
Bipolar Disorder (2011)	1.6	1.5	3.0	0.4	-1.1	1.3	1.2	1.4	1.7	1.2	1.6	0.9	0.9	1.1	1.4	1.3
Body Mass Index (BMI) (2010)	0.3	0.5	3.1	1.8	0.6	0.7	0.8	-0.5	-0.3	0.3	0.4	-0.5	-0.4	-0.5	-0.3	-0.2
Coronary Artery Disease (CAD)	0.4	0.4	1.4	-1.1	-0.2	-0.6	-0.6	-0.4	-0.1	-0.8	-1.2	0.2	0.1	0.0	-0.6	-0.9
Crohns Disease (2012)	0.6	1.0	6.4	-0.5	-2.5	0.4	-0.0	1.1	1.0	0.3	1.1	0.2	0.2	0.1	1.2	1.0
Mean Putamen Volume	1.1	1.3	9.5	0.6	3.1	0.2	-0.0	-1.2	-1.3	0.2	0.8	-0.8	-1.1	-0.8	-0.5	-0.1
Fasting Glucose	3.0	3.6	7.1	-0.2	1.4	-1.3	-1.4	-2.0	-1.1	-2.7	-0.7	-2.4	-2.4	-2.5	-2.2	-2.5
HbA1C	1.4	1.5	3.0	-0.4	-0.1	-1.6	-1.2	-1.4	-0.8	-1.1	-1.6	-1.7	-1.5	-1.6	-0.6	-1.1
HDL Cholesterol	0.4	0.7	1.8	-0.7	-1.3	-0.5	-0.3	1.3	0.0	0.9	-0.6	0.8	1.0	0.8	0.9	0.7
LDL Cholesterol	4.4	7.0	18.8	-3.1	2.5	-3.0	-3.3	-3.3	-2.8	-4.3	-1.5	-2.2	-1.9	-1.8	-1.3	-1.3
Lupus	1.2	1.8	5.6	-2.0	-0.9	-0.3	-0.6	0.9	0.6	-0.4	-1.1	0.9	1.3	1.3	2.4	2.3
Neuroticism (2016)	0.7	1.0	3.7	0.2	0.1	-0.7	-0.6	-1.0	-1.0	-0.7	1.1	-0.8	-0.8	-0.6	-1.9	-1.9
Primary Biliary Cirrhosis	0.1	0.2	0.6	0.1	0.7	0.4	0.3	0.0	0.7	0.1	0.8	0.1	-0.2	-0.2	0.4	0.3
Rheumatoid Arthritis	0.5	0.6	1.4	-0.6	0.8	-1.2	-1.2	-0.8	-0.9	-1.0	0.2	-0.7	-0.6	-0.7	-0.6	-0.5
Schizophrenia (2014)	0.6	1.4	5.3	2.3	0.2	1.6	1.3	0.2	1.2	1.1	-1.6	-0.4	-0.8	-0.9	0.7	1.0
Triglycerides	0.7	1.2	4.0	-0.1	1.5	-1.0	-0.9	-1.6	-1.1	-2.0	-1.0	-0.8	-0.6	-0.5	-1.0	-0.9
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.7	-0.5	-0.3	0.3	-0.1	-0.3	0.8	-0.8	0.7	-0.1	-0.3	-0.1	0.3	0.3
Ulcerative Colitis	0.5	0.7	2.9	1.2	1.0	0.2	0.6	-0.4	-0.4	0.3	0.3	-0.4	-0.7	-0.9	-1.7	-1.3
Blood Eosinophil Count	0.7	5.3	10.5	0.7	1.9	-1.5	-1.6	-2.2	-2.1	-1.7	-0.3	-3.0	-3.1	-3.2	-3.0	-3.0
Blood Platelet Count	0.1	1.6	3.9	0.1	0.9	-1.6	-1.7	-0.5	-0.9	-0.5	1.7	-2.0	-1.5	-1.5	-1.0	-1.1
Blood Red Count	0.5	4.4	21.9	-4.7	-1.5	-2.2	-2.3	-0.8	-1.5	-2.5	-1.2	1.4	1.8	2.4	0.9	0.9
Blood White Count	0.8	5.6	16.3	0.9	-1.4	2.4	1.6	2.7	2.8	2.4	1.2	1.5	1.5	1.5	4.0	4.0
Heel T-Score	1.2	9.9	23.2	3.7	-1.8	4.7	4.8	3.5	3.9	4.6	1.6	2.1	1.6	1.1	1.9	1.9
BMI	0.2	1.0	2.9	1.7	0.6	1.2	1.2	-0.9	-0.0	-0.4	-1.1	-0.5	-0.8	-1.0	-1.1	-1.1
Height	0.1	2.5	10.2	-2.0	-1.2	0.7	0.0	0.3	0.7	-0.5	-0.4	1.3	1.4	1.8	3.0	3.2
Waist Hip Ratio (WHR)	0.5	2.3	4.5	-1.1	1.5	-1.2	-1.7	-1.9	-1.6	-1.6	0.1	-2.1	-2.0	-1.8	-1.0	-0.8
Systolic Blood Pressure	0.6	2.8	4.7	1.3	-0.8	2.0	2.2	1.6	1.1	2.1	0.3	1.9	1.8	1.8	1.7	1.9
Smoking Status	3.7	8.8	19.0	-0.6	-4.3	2.3	1.9	3.1	4.4	1.7	0.6	3.0	3.0	3.0	3.8	3.6
Allergy or Eczema	2.8	7.5	14.0	0.4	3.2	-1.9	-1.6	-2.7	-3.5	-1.1	-0.2	-3.2	-3.3	-3.4	-3.7	-3.7
Cardiovascular Disease	1.0	3.2	7.6	0.3	1.7	-1.6	-1.4	-2.2	-2.8	-2.0	-1.8	-1.6	-1.5	-1.7	-2.0	-1.9
Hypothyroidism (self reported)	0.2	0.4	2.3	-0.4	0.5	-0.5	-0.7	-0.8	-1.5	-0.7	0.4	-0.3	-0.1	0.1	0.6	0.8
Respiratory disease	0.9	2.1	4.3	1.5	1.7	-0.4	-0.2	-1.0	-1.7	0.0	-1.1	-1.5	-1.5	-1.7	-2.1	-2.1
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.9	-1.0	0.7	-0.4	-0.6	-0.8	-0.5	-0.9	-0.2	-0.6	-0.5	-0.3	-0.2	-0.2
Lung FEV1/FVC ratio	0.2	0.9	3.3	-1.6	-0.3	0.3	-0.3	0.4	1.2	-0.7	-0.9	0.3	0.2	0.2	1.7	1.8
Lung FVC	0.2	1.1	3.8	-1.4	-0.7	-0.8	-1.0	-1.2	-0.6	-1.9	-0.1	0.9	1.1	1.4	0.5	0.7
Neuroticism	1.9	4.5	10.2	2.8	2.8	-0.9	-0.5	-1.5	-2.4	0.4	0.6	-2.1	-2.1	-2.2	-3.2	-3.1
Chronotype (morning person)	2.0	4.6	11.4	0.1	-1.9	1.4	1.2	2.0	1.5	1.2	0.0	2.7	2.8	2.9	3.2	3.4
Hair Pigment	0.1	1.9	3.7	0.2	1.7	-1.5	-1.4	-1.5	-1.7	-1.0	0.0	-1.2	-1.1	-1.2	-1.9	-1.9
Tanning	0.8	9.9	21.7	-0.1	-3.8	2.9	2.6	3.8	4.7	2.8	1.3	3.1	3.0	3.1	3.7	3.5
Hand grip strength (left)	1.7	4.5	8.1	-0.8	-2.6	1.6	1.3	2.2	2.3	0.9	-0.6	2.6	2.6	2.6	2.9	2.7
Number of treatments/medications taken	0.8	1.4	4.7	0.1	0.6	-0.9	-0.6	-1.3	-1.3	-0.9	-0.2	-1.1	-0.9	-1.1	-2.1	-2.2
Average weekly spirits intake	1.1	1.4	3.4	-0.1	-1.2	0.8	0.8	1.8	1.2	1.3	-1.1	1.1	1.2	1.2	1.5	1.3
Sensitivity / hurt feelings	3.7	6.3	12.0	1.9	3.4	-1.0	-0.8	-2.5	-2.6	-0.4	-0.5	-3.0	-3.2	-3.2	-3.5	-3.3
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.3	1.0	0.8	-0.4	0.2	-0.3	-0.2	0.4	0.7	-0.1	-0.1	-0.2	-1.5	-1.5
Hearing difficulty/problems: Yes	0.7	1.0	5.6	0.3	2.4	-1.0	-0.8	-0.8	-1.0	-0.3	-0.4	-0.8	-0.6	-0.9	-1.1	-0.8
Relative age of first facial hair	0.5	1.1	3.3	-1.0	1.2	-1.4	-1.3	-1.0	-1.8	-0.7	1.0	-0.8	-0.6	-0.5	-0.6	-0.7
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.9	-0.6	0.2	0.4	0.2	-1.0	-1.4	-1.0	0.7	0.4	0.3	0.6	0.5	0.9
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.9	-0.1	-0.1	0.3	0.0	-0.0	0.4	0.1	-0.9	-0.2	-0.1	-0.1	0.8	0.9
Ever had hysterectomy (womb removed)	0.2	0.3	1.5	-0.2	0.4	0.5	0.5	0.4	0.5	0.6	1.2	-0.5	-0.3	-0.3	0.1	-0.0
Systolic blood pressure, automated reading	0.5	1.4	4.0	0.9	-0.4	1.4	1.8	1.4	1.0	2.0	-0.1	0.9	1.1	1.0	0.9	1.0
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	5.1	2.2	-0.3	1.0	1.0	0.5	1.3	0.6	1.8	-0.3	-0.5	-0.6	0.6	0.6
Angina	0.4	0.6	1.5	-0.2	0.0	-1.0	-0.8	-0.5	-0.9	-1.2	-0.8	-0.4	-0.1	-0.3	-0.9	-1.2
Medication for hormone replacement therapy	0.3	0.3	1.7	-0.2	-1.3	0.6	0.6	0.4	1.1	0.4	0.1	0.4	0.4	0.4	-0.0	-0.3
Vitamin and mineral supplements	6.0	8.1	15.5	0.1	3.3	-2.5	-2.7	-3.2	-3.9	-2.2	-0.3	-3.6	-3.5	-3.5	-2.7	-2.5
Supplements: Zinc	1.5	1.6	3.6	-1.9	-1.9	-0.1	0.0	1.2	0.9	0.4	-0.3	1.4	1.6	1.6	1.6	1.5
Medication: Co-codamol	0.5	0.6	1.7	1.1	0.2	0.6	0.4	0.7	1.0	1.0	1.3	0.3	0.1	0.1	0.9	0.9
Medication: Metformin	1.1	1.5	2.9	-1.1	1.1	-1.1	-1.2	-1.6	-1.4	-1.7	-0.2	-1.4	-1.2	-1.0	-1.2	-1.2
Diabetes (father)	0.9	1.1	3.0	1.4	-0.5	1.4	1.7	0.7	1.5	1.7	-0.4	0.7	0.3	0.3	-0.2	-0.0
Diabetes (mother)	2.7	3.5	6.9	-1.1	2.6	-1.6	-1.4	-2.5	-2.0	-1.9	-1.5	-2.0	-2.1	-1.9	-1.7	-1.4
Severe depression (siblings)	2.0	2.2	5.5	-0.2	1.9	-0.7	-0.7	-2.1	-2.3	-1.5	-1.6	-1.4	-1.4	-1.3	-1.4	-1.3
Pack years adult smoking proportion	0.3	0.5	1.3	0.5	0.2	0.8	0.9	0.8	1.0	1.1	1.1	0.6	0.5	0.4	0.3	0.3
Impedance of leg (right)	0.4	1.8	3.5	-1.8	-1.7	-0.6	-0.5	1.4	1.0	0.6	1.2	1.3	1.8	1.9	1.4	1.4
Leg fat-free mass (left)	0.1	0.4	1.4	0.5	0.4	1.2	0.8	-0.6	-0.1	-0.4	-1.0	-0.3	-0.7	-0.6	0.7	0.7
Trunk fat percentage	0.6	2.3	4.7	-0.9	0.9	-1.2	-1.4	-1.6	-1.5	-1.6	-1.3	-2.2	-2.1	-2.1	-1.0	-1.0
Hand grip strength (right)	1.2	3.3	6.2	-1.0	-2.1	1.3	1.0	1.5	1.4	0.3	-0.7	2.5	2.5	2.4	2.4	2.4
Townsend deprivation index at recruitment	1.4	2.0	4.0	1.3	-1.3	1.1	1.2	2.0	1.5	1.7	0.4	1.6	1.6	1.6	1.2	1.1
Current tobacco smoking	4.0	6.5	13.8	-0.7	-3.7	1.9	1.8	3.1	3.6	2.0	1.1	2.7	2.7	2.6	2.9	2.6
Average weekly fortified wine intake	0.6	0.7	1.5	1.2	0.8	0.1	-0.0	-0.6	-0.9	-0.3	0.1	-1.1	-1.1	-1.2	-0.8	-0.8
Maternal smoking around birth	1.0	1.5	3.4	0.1	-1.3	1.4	1.3	1.2	1.9	0.6	1.1	1.2	1.3	1.1	1.2	1.1
Fed-up feelings	0.4	0.8	3.6	1.9	1.0	0.4	0.5	-0.4	-0.1	0.5	0.4	-0.4	-0.4	-0.4	-1.3	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	3.0	0.5	0.6	-0.3	0.0	0.3	0.0	0.9	1.7	0.1	0.1	0.1	-0.7	-0.7
Relative age voice broke	0.4	0.6	2.1	-1.0	0.9	-1.0	-1.0	-0.3	-1.4	-0.2	0.9	-0.6	-0.3	-0.2	-0.0	0.0
Taking other prescription medications	0.2	0.2	0.7	-0.8	0.3	-0.3	-0.3	-0.1	-0.8	-0.5	-0.0	0.4	0.6	0.6	0.4	0.5
Age when periods started (menarche)	0.2	0.5	1.3	1.1	-0.2	0.6	0.8	0.4	0.9	0.7	0.4	0.7	0.9	0.9	0.3	0.4
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	3.2	0.2	-1.8	1.3	1.1	1.1	1.6	0.9	0.0	-0.1	-0.2	-0.2	1.0	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.6	-0.3	-1.0	1.1	1.2	0.7	0.4	0.4	-1.6	1.3	1.3	1.2	0.2	0.2
Tinnitus: Yes, but not now, but have in the past	3.8	4.0	10.2	1.7	2.7	-0.6	-0.6	-3.2	-1.9	-1.8	-0.9	-1.9	-2.1	-2.0	-2.6	-2.2
Qualifications: CSEs or equivalent	0.4	0.5	2.8	-0.4	0.6	-0.5	-0.5	-0.3	-0.6	-0.4	-1.7	-0.7	-0.9	-1.0	0.1	0.1
Serious illness, injury or assault to yourself	0.2	0.3	2.6	-0.4	0.5	-0.5	-0.4	0.0	-0.3	-0.1	1.6	0.2	0.1	0.0	-0.0	0.0
High blood pressure	0.5	1.5	3.3	1.1	1.2	-0.6	-0.3	-1.3	-1.7	-0.8	-1.3	-1.1	-0.9	-1.1	-1.8	-1.7
Hayfever, allergic rhinitis or eczema	2.0	4.4	8.9	-0.2	2.5	-1.6	-1.5	-1.9	-3.0	-0.7	-0.1	-2.6	-2.6	-2.6	-2.6	-2.5
Multivitamins +/- minerals	2.8	3.6	6.8	-0.3	-2.5	1.5	1.4	1.9	2.6	0.9	0.2	2.2	2.4	2.4	2.1	2.0
Stomach or abdominal pain in last month	0.1	0.2	0.5	0.7	-0.3	-0.1	0.2	0.2	-0.2	0.2	-0.7	0.3	0.4	0.1	-0.6	-0.5
Supplements: Glucosamine	1.1	1.5	3.0	0.8	-1.2	1.4	1.5	1.6	1.7	1.7	0.4	0.8	1.1	1.0	1.0	0.9
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	5.7	-1.0	1.0	-1.9	-1.8	-1.6	-1.3	-1.6	0.2	-2.4	-2.0	-1.9	-1.5	-1.5
Medication: Atenolol	0.3	0.4	1.1	-0.5	-0.3	-0.9	-0.7	0.1	-0.7	-0.2	-1.1	-0.5	-0.3	-0.4	-0.8	-0.9
Medication: Levothyroxine sodium	0.5	0.9	2.7	-0.2	0.5	-0.7	-1.1	-1.6	-1.7	-1.4	0.1	-1.1	-1.0	-0.7	-0.1	-0.0
Sitting height	0.7	5.0	13.4	-0.8	-2.2	2.0	1.4	1.7	2.1	1.0	0.8	2.4	2.4	2.7	3.5	3.7
Chronic bronchitis/emphysema (father)	0.6	0.7	1.8	1.3	0.2	1.4	1.1	0.3	1.0	0.9	0.5	-0.5	-0.7	-0.7	0.6	0.7
High blood pressure (mother)	2.0	2.8	7.8	-2.6	0.5	-2.1	-2.0	-1.7	-2.1	-2.8	-1.0	-1.1	-0.8	-0.8	-1.2	-1.3
Body mass index (BMI)	0.5	2.2	4.8	1.4	1.8	0.1	0.1	-1.6	-1.2	-0.8	-1.2	-1.9	-2.0	-2.2	-1.6	-1.5
Impedance of leg (left)	0.3	1.6	2.9	-1.7	-1.6	-0.8	-0.8	1.3	0.9	0.4	1.1	1.2	1.6	1.7	1.3	1.3
Leg predicted mass (left)	0.1	0.4	1.4	0.5	0.4	1.2	0.8	-0.6	-0.1	-0.4	-1.0	-0.3	-0.6	-0.6	0.7	0.7
Trunk fat mass	0.3	1.3	3.1	-0.4	0.8	-0.5	-0.8	-1.2	-1.0	-1.2	-1.1	-1.7	-1.7	-1.8	-0.5	-0.5
Waist circumference	0.5	1.7	4.8	0.4	1.6	-0.0	-0.4	-1.7	-1.2	-1.0	-0.2	-2.0	-2.2	-2.1	-0.7	-0.5
Number of incorrect matches in round	1.0	1.6	4.8	2.2	1.9	-0.4	0.2	-0.3	-0.7	0.5	-0.5	-1.1	-1.0	-1.3	-1.9	-2.0
Past tobacco smoking	1.3	2.4	4.9	-1.4	2.1	-2.0	-1.7	-1.1	-2.2	-1.4	0.4	-1.3	-1.1	-1.1	-1.6	-1.8
Alcohol usually taken with meals	0.3	0.5	2.3	0.2	-0.7	0.5	0.2	0.2	-0.0	0.4	-0.7	0.4	0.5	0.6	1.4	1.5
Nervous feelings	6.3	11.8	22.9	0.5	4.0	-3.2	-2.7	-3.6	-4.8	-2.2	-2.6	-3.3	-3.0	-3.1	-4.7	-4.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	4.3	2.1	0.4	0.8	1.4	0.9	0.9	2.0	1.7	0.3	0.1	-0.1	-1.2	-1.2
Hearing difficulty/problems with background noise	3.0	4.8	13.5	1.9	3.7	-1.5	-1.1	-1.7	-2.2	-0.1	-0.2	-2.5	-2.5	-2.8	-2.7	-2.5
Hair/balding pattern: Pattern 2	0.2	0.2	0.8	0.6	-0.0	-0.2	-0.2	0.9	-0.3	0.7	0.0	0.1	0.4	0.2	0.7	0.8
Had menopause	0.5	0.6	2.1	1.4	-0.8	1.2	1.1	0.0	0.9	0.5	-0.8	-0.4	-0.4	-0.4	-0.2	-0.2
Had other major operations	0.2	0.2	1.1	0.3	1.1	-0.5	-0.6	0.1	-0.5	0.1	0.8	-0.0	-0.0	-0.2	0.1	0.2
Forced vital capacity (FVC)	0.8	2.9	7.9	-2.8	-1.8	-0.5	-1.0	-0.3	-0.1	-2.0	0.0	1.6	1.8	2.2	2.2	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.6	-0.7	-1.3	1.0	1.1	1.0	0.8	0.4	-1.5	1.5	1.6	1.5	0.8	0.8
Ever unenthusiastic/disinterested for a whole week	3.3	4.1	10.8	0.4	3.3	-1.4	-1.2	-2.4	-1.9	-1.6	-0.6	-2.1	-2.0	-1.9	-2.6	-2.7
Qualifications: None of the above	0.1	0.3	0.8	0.1	-0.7	-0.5	-0.4	-0.5	0.3	-0.9	-0.5	-0.4	-0.2	-0.3	-0.9	-0.8
Financial difficulties in last 2 years	0.7	1.0	3.6	1.9	0.5	0.8	1.0	0.7	1.1	0.8	0.3	1.0	1.0	0.9	1.0	1.1
Mouth/teeth dental problems	0.2	0.3	1.2	-1.0	0.2	-0.4	-0.5	-0.3	0.0	-0.2	1.1	-0.6	-0.6	-0.5	-0.4	-0.6
Heart attack	1.1	1.4	6.2	1.5	-0.6	0.2	0.6	-0.5	-0.2	-0.0	-1.3	-0.5	-0.7	-0.9	-2.3	-2.5
Allergy	1.9	4.4	9.6	-0.2	-2.0	1.6	1.5	1.7	3.1	0.7	0.4	2.7	2.6	2.7	2.6	2.6
Pain all over the body in last month	0.4	0.5	2.8	-1.7	-0.2	-1.1	-1.0	0.0	0.1	-0.9	-0.1	0.0	0.5	0.3	0.1	0.2
Diabetes (self-reported)	0.1	0.2	0.3	0.3	0.5	0.5	0.3	0.1	0.6	0.2	0.3	-0.6	-0.6	-0.5	-0.1	-0.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.5	-0.0	0.9	0.1	0.2	0.3	-0.5	1.2	1.0	-0.8	-0.7	-0.6	-1.0	-1.2
Medication: Ramipril	0.2	0.2	1.0	1.0	-0.0	0.8	0.8	-0.2	0.3	-0.0	-0.7	0.2	0.0	0.0	-0.4	-0.2
Medication: Simvastatin	0.2	0.3	1.0	0.1	-0.7	0.4	0.2	-0.4	-0.3	0.1	-0.1	-0.9	-1.0	-1.0	-0.5	-0.7
Fluid intelligence score	0.4	0.9	2.5	-1.5	-1.6	1.0	0.8	0.8	1.0	0.6	0.5	0.3	0.2	0.3	1.2	1.1
Illnesses of siblings	0.5	0.7	1.2	-1.0	-0.0	-0.9	-1.0	-0.7	-0.9	-1.0	-0.2	-0.7	-0.8	-0.8	-1.1	-1.1
Neuroticism score	2.1	4.4	10.4	2.6	2.6	-0.8	-0.4	-1.4	-2.3	0.6	0.0	-2.2	-2.2	-2.4	-3.2	-3.1
Weight	0.1	0.5	1.3	0.5	1.0	0.5	0.3	-0.9	-0.5	-0.6	-0.7	-1.0	-1.1	-1.1	0.1	0.2
Impedance of arm (right)	0.5	2.2	12.7	-3.6	-0.6	-2.3	-2.4	-0.3	-0.9	-1.3	0.9	-0.3	0.1	0.5	0.6	0.6
Arm fat percentage (right)	0.9	3.7	6.9	-0.2	2.1	-1.4	-1.3	-2.1	-2.1	-1.7	-1.1	-2.6	-2.5	-2.6	-1.9	-1.9
Trunk fat-free mass	0.3	1.7	5.7	1.5	-0.5	2.4	2.0	0.7	1.1	1.0	-0.2	0.8	0.5	0.6	1.7	1.8
Hip circumference	0.1	0.3	0.6	0.2	0.8	0.4	0.2	-0.6	-0.2	-0.5	-0.2	-0.7	-0.8	-0.7	0.6	0.6
Time employed in main current job	0.6	0.7	4.0	-1.3	0.3	-1.0	-1.1	0.7	-0.1	0.2	2.0	-0.5	-0.4	-0.3	0.5	0.2
Alcohol intake versus 10 years previously	0.2	0.4	1.3	-1.1	0.2	-0.4	-0.2	0.5	0.3	0.0	-0.4	0.6	0.9	0.9	0.6	0.7
Father’s age at death	0.4	0.5	1.5	-0.7	-0.7	-0.9	-0.9	-0.3	-1.2	-0.9	-1.2	0.1	0.2	0.2	0.2	0.2
Worrier / anxious feelings	2.6	4.9	10.8	1.5	3.1	-0.7	-0.2	-2.3	-3.3	-0.1	-0.9	-2.0	-2.2	-2.2	-3.3	-3.1
Frequency of tiredness / lethargy in last 2 weeks	2.6	4.2	10.8	1.7	2.5	-1.4	-0.8	-1.7	-2.5	-0.5	1.2	-1.9	-1.9	-2.0	-3.2	-3.3
Falls in the last year	3.4	4.7	6.7	2.3	-1.7	2.4	2.5	2.6	2.2	2.4	2.3	2.2	2.1	1.9	1.7	1.6
Hair/balding pattern: Pattern 3	3.2	4.7	10.2	1.3	2.5	-0.5	-0.3	-3.1	-1.9	-1.6	-1.7	-2.0	-2.3	-2.2	-3.2	-3.1
Number of live births	0.6	0.9	2.9	0.8	1.0	0.2	-0.1	-1.7	-0.5	-0.7	-0.4	-1.1	-1.4	-1.3	-1.0	-0.6
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	9.7	-3.1	-1.1	-0.8	-1.4	-0.8	-0.5	-2.5	-0.6	0.8	0.9	1.3	1.8	1.9
Pulse rate	0.5	0.9	2.2	-0.4	-0.5	0.3	0.1	1.1	1.4	1.3	0.9	0.6	0.6	0.4	1.5	1.5
Happiness	0.4	0.5	1.4	-0.0	0.4	-0.1	-0.2	-1.2	-0.8	-0.6	0.8	-0.8	-0.9	-0.7	-0.9	-0.9
Noisy workplace	2.8	3.4	6.7	-0.3	1.7	-1.5	-1.5	-2.0	-1.9	-1.7	-0.7	-2.6	-2.5	-2.6	-1.8	-1.8
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.7	0.5	0.6	0.4	0.2	-0.4	-0.8	0.3	0.7	0.0	-0.0	-0.0	0.1	0.3
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	4.9	0.4	1.2	-0.8	-0.5	-0.7	-1.3	-0.4	-1.3	-1.4	-1.5	-1.7	-2.1	-2.2
Mouth/teeth dental problems: Dentures	0.5	0.9	4.0	2.0	-0.8	1.3	1.5	0.6	0.9	0.6	-0.9	0.6	0.5	0.4	-0.1	0.0
Asthma	1.0	2.0	4.6	1.0	2.1	-0.7	-0.5	-1.1	-2.0	0.0	-1.0	-1.7	-1.5	-1.6	-1.7	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	3.9	-1.0	-2.0	-0.2	0.1	0.7	0.5	-0.2	-0.6	1.1	1.1	1.0	0.3	0.1
Medication: Cholesterol lowering	0.3	0.5	2.3	0.5	-0.7	-0.3	0.0	-0.4	-0.5	-0.2	-0.9	-0.3	-0.3	-0.4	-1.3	-1.5
Depression (self-reported)	2.0	2.5	5.5	-0.3	1.5	-1.4	-1.3	-1.2	-1.3	-1.0	0.4	-1.8	-2.0	-2.0	-2.1	-2.3
Medication: Lansoprazole	0.2	0.2	0.8	-0.4	-0.8	0.2	0.2	0.7	0.9	0.3	0.0	0.2	0.2	0.1	0.4	0.3
Prospective memory result	1.6	1.9	8.1	2.8	1.7	-0.4	0.0	-0.8	-0.4	0.2	0.3	-1.0	-0.9	-1.2	-2.1	-2.2
Lung cancer (father)	0.3	0.3	1.0	0.3	0.1	1.0	0.8	0.3	0.6	0.7	0.6	-0.6	-0.8	-0.6	-0.1	-0.2
Illnesses of mother	1.9	2.3	6.8	2.3	-1.1	1.3	1.4	2.0	1.5	2.6	0.6	1.4	1.3	1.1	1.0	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	4.5	-2.1	-1.0	0.0	-0.7	-0.6	-0.2	-1.8	-0.2	1.2	1.1	1.4	1.9	2.1
Pulse wave Arterial Stiffness index	0.5	0.6	2.9	0.0	-0.5	-0.2	-0.0	1.7	1.2	0.9	0.7	0.4	0.4	0.1	1.1	0.9
Impedance of arm (left)	0.7	3.1	17.4	-4.2	-1.2	-2.7	-3.0	-0.1	-0.8	-1.4	1.1	-0.4	0.0	0.3	0.9	0.9
Arm fat mass (right)	0.4	1.7	3.9	0.5	1.4	-0.3	-0.3	-1.5	-1.4	-1.1	-1.0	-1.9	-1.9	-2.0	-1.2	-1.2
Trunk predicted mass	0.4	2.0	6.4	1.6	-0.5	2.5	2.2	0.8	1.2	1.2	-0.0	0.9	0.6	0.7	1.8	1.9
Standing height	0.4	4.1	14.9	-1.4	-1.8	1.3	0.6	1.4	1.5	0.6	1.0	1.8	1.8	2.2	3.8	3.9
Length of working week for main job	1.7	1.9	4.4	-0.1	-1.7	0.8	0.5	2.0	1.6	1.2	1.5	0.8	0.8	0.8	2.1	1.9
Exposure to tobacco smoke at home	5.5	6.2	11.9	1.3	3.4	-2.4	-2.0	-2.3	-2.3	-1.8	-0.4	-2.6	-2.3	-2.7	-3.5	-3.4
Breastfed as a baby	1.7	2.2	5.0	0.4	-1.5	2.0	2.2	1.5	1.4	1.5	0.2	1.8	1.7	1.8	0.8	0.7
Tense / ‘highly strung’	3.6	6.0	15.1	2.6	3.4	-0.9	-0.3	-2.2	-2.4	-0.2	1.1	-2.2	-2.4	-2.6	-3.9	-3.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	3.1	-0.3	1.0	-1.5	-1.0	-1.0	-1.7	-0.5	0.9	-0.6	-0.5	-0.6	-1.7	-1.7
Hair/balding pattern: Pattern 4	0.2	0.4	1.1	-1.1	0.1	-0.8	-0.8	-0.2	-0.1	-0.5	-1.1	-0.6	-0.6	-0.7	-0.4	-0.4
Birth weight of first child	0.8	1.4	3.5	-0.1	1.4	-1.7	-1.5	-1.4	-1.9	-1.2	-0.9	-0.8	-0.6	-0.8	-1.2	-1.0
Peak expiratory flow (PEF)	0.2	0.6	1.7	-1.3	-0.6	-0.0	-0.5	-0.8	-0.4	-1.3	-0.4	0.2	0.2	0.4	0.9	1.2
Pulse wave reflection index	1.6	1.9	5.2	0.3	-1.2	0.8	0.9	2.3	1.6	1.4	0.1	1.6	1.6	1.4	1.7	1.5
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.5	1.0	-0.0	0.5	0.4	-0.2	0.7	0.4	1.6	-1.0	-1.2	-1.1	-0.5	-0.5
Loud music exposure frequency	0.4	0.4	1.8	0.8	0.3	-0.1	0.2	-0.3	0.0	0.2	-0.0	-0.5	-0.6	-0.8	-1.3	-1.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.6	0.4	0.1	0.8	0.7	0.3	0.2	0.7	-0.1	0.1	-0.2	-0.2	0.4	0.4
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.2	0.0	1.1	-1.1	-1.1	-1.4	-1.0	-1.1	-1.5	-1.1	-1.0	-1.1	-1.1	-0.8
Blood clot in the leg (DVT)	1.3	1.7	3.2	0.5	1.5	-1.0	-1.0	-1.1	-1.8	-0.4	1.3	-1.5	-1.4	-1.4	-1.7	-1.6
Medication: Paracetamol	0.2	0.4	1.0	0.6	0.5	-0.7	-0.5	-0.8	-0.2	-0.7	0.4	-0.4	-0.3	-0.6	-1.0	-0.8
Headache pain in last month	0.3	0.6	2.1	0.6	1.0	-0.2	0.2	-0.5	-0.2	0.2	0.5	-0.6	-0.6	-0.8	-1.4	-1.5
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.8	-1.3	-0.4	0.1	-0.2	0.7	0.8	0.2	1.0	0.5	0.4	0.6	1.9	2.0
Glaucoma (self-reported)	0.1	0.1	0.5	-0.7	-0.3	0.1	0.3	-0.3	-0.4	-0.5	-0.3	0.4	0.3	0.5	0.1	0.0
Gout (self-reported)	1.6	2.2	4.1	-1.0	2.0	-0.8	-0.6	-1.8	-1.9	-1.0	-1.0	-1.4	-1.6	-1.5	-2.0	-1.9
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	3.4	-0.0	0.8	-0.5	-0.6	-1.2	-1.8	-0.8	0.5	-0.7	-0.6	-0.3	-0.2	-0.1
Medication: Amlodipine	0.9	1.2	5.0	2.2	0.8	0.6	1.1	-0.4	-0.4	0.8	-0.1	-0.3	-0.5	-0.5	-1.9	-1.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.5	0.8	1.2	0.4	0.5	0.0	-0.5	0.5	0.5	-0.6	-0.5	-0.7	-0.7	-0.7
Birth weight	0.3	0.6	1.9	-1.4	0.0	0.7	0.4	-0.4	0.3	-0.8	1.0	0.6	0.5	0.8	0.8	1.0
Chronic bronchitis/emphysema (mother)	1.3	1.5	3.8	-0.7	-0.2	-0.0	-0.2	-1.8	0.3	-1.5	-1.0	-1.8	-2.0	-1.8	-1.0	-0.9
High blood pressure (siblings)	0.5	0.8	1.6	0.5	-0.1	0.6	0.8	0.9	0.8	0.7	0.5	0.8	1.2	1.2	1.2	1.3
Forced vital capacity (FVC), Best measure	0.6	2.1	4.9	-2.0	-1.4	0.1	-0.5	-0.5	-0.1	-1.8	0.0	1.6	1.5	1.9	2.0	2.2
Body fat percentage	0.6	2.4	5.0	-0.4	1.3	-1.2	-1.2	-1.6	-1.5	-1.5	-1.1	-2.2	-2.1	-2.2	-1.4	-1.4
Leg fat percentage (right)	0.4	1.3	2.8	0.5	1.3	-0.5	-0.2	-1.0	-1.0	-0.6	-0.6	-1.7	-1.5	-1.7	-1.5	-1.5
Arm fat-free mass (right)	0.3	1.6	5.3	1.8	-0.5	2.3	2.0	0.8	1.2	1.1	-0.3	0.8	0.4	0.4	1.4	1.4
Exposure to tobacco smoke outside home	0.2	0.3	1.2	-1.1	-0.5	-0.6	-0.7	-0.2	0.1	-0.8	0.4	0.1	0.1	0.4	0.3	0.2
Comparative body size at age 10	0.6	1.7	4.7	-2.1	1.1	-2.1	-2.2	-0.4	-1.2	-1.8	-1.0	0.2	0.5	0.2	0.6	0.8
Number of full brothers	1.5	1.9	4.5	-0.9	1.3	-2.0	-2.1	-1.4	-1.5	-2.0	-2.0	-0.7	-0.2	-0.3	-0.6	-0.4
Worry too long after embarrassment	1.8	3.0	6.5	2.2	1.1	-0.0	0.4	-0.9	-1.4	1.1	0.3	-2.1	-2.3	-2.4	-2.5	-2.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	6.6	0.4	-0.1	0.1	0.4	1.2	0.7	1.0	2.6	0.9	0.9	1.0	0.7	0.5
Wheeze or whistling in the chest in last year	1.5	2.7	8.5	1.2	1.8	-1.3	-0.8	-1.2	-1.6	-0.2	-0.4	-1.4	-1.4	-1.7	-2.9	-2.9
Number of children fathered	2.7	3.1	5.7	1.1	-0.6	2.1	2.4	1.8	2.0	1.8	1.9	2.3	1.9	1.6	1.2	1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	6.4	2.1	0.2	2.5	2.5	-0.7	0.8	0.8	-0.1	0.2	-0.2	-0.0	-0.7	-0.5
Age at first live birth	0.3	0.6	1.7	-1.3	-0.5	0.3	0.2	-0.2	0.3	-0.2	-0.5	0.8	0.7	0.9	1.1	1.2
Pulse wave peak to peak time	0.4	0.5	2.4	-0.2	0.3	0.2	0.0	-1.6	-1.1	-0.8	-0.6	-0.2	-0.3	-0.0	-0.9	-0.7
Health satisfaction	0.3	0.3	1.1	0.0	-0.0	-0.3	-0.2	-0.8	-0.5	-0.5	0.4	-0.5	-0.5	-0.6	-1.0	-0.8
Shortness of breath walking on level ground	1.7	2.1	4.1	1.8	1.8	-0.7	-0.4	-0.8	-0.9	0.1	0.4	-1.9	-1.9	-2.0	-1.8	-1.9
Qualifications: College or University degree	0.1	0.4	1.9	-0.8	0.7	0.3	0.1	0.3	0.0	0.2	1.4	0.2	0.2	0.3	0.9	1.1
Eye problems/disorders: None of the above	1.1	1.3	4.2	-0.9	0.2	-1.3	-1.4	-1.3	-1.5	-2.1	-1.4	-0.7	-0.5	-0.5	-0.7	-0.7
Mouth/teeth dental problems: Loose teeth	3.8	4.5	7.0	0.7	-2.2	2.3	2.3	2.6	2.4	2.7	-0.0	2.1	2.0	2.0	2.3	2.2
Emphysema/chronic bronchitis	1.4	1.6	3.8	0.8	-1.8	1.2	1.5	1.5	2.0	1.3	0.2	1.3	1.1	0.9	0.9	0.7
Medication for pain relief, constipation, heartburn	0.4	0.6	2.4	-1.5	-0.1	0.1	-0.4	0.6	-0.1	-0.2	-0.1	0.4	0.4	0.7	1.6	1.5
Neck or shoulder pain in last month	0.3	0.5	1.3	0.5	0.6	0.3	0.6	0.1	0.9	0.5	1.2	0.1	-0.0	-0.2	-1.1	-1.0
Medication: Blood pressure	0.5	0.9	3.2	1.7	0.6	0.0	0.5	-0.5	-0.6	-0.0	-1.0	-0.0	0.1	-0.2	-1.8	-1.8
Angina (self-reported)	0.1	0.2	0.4	-0.2	-0.5	-0.5	-0.3	0.3	-0.2	-0.6	-0.4	0.2	0.5	0.3	-0.3	-0.6
Migraine (self-reported)	1.9	2.4	5.3	-1.4	1.4	-1.8	-1.7	-1.6	-2.3	-1.1	-0.3	-1.4	-1.4	-1.2	-1.8	-1.8
Medication: Ibuprofen	1.0	1.1	5.3	-1.6	-2.3	0.2	0.4	0.9	0.8	-0.0	-0.0	1.3	1.2	1.1	0.8	0.6
Medication: Allopurinol	1.3	1.7	5.8	-0.0	2.4	0.1	0.3	-1.6	-1.4	-0.5	0.1	-1.2	-1.4	-1.4	-1.9	-1.8
Medication: Omeprazole	0.2	0.3	1.6	0.4	-0.3	0.0	-0.1	-0.5	-0.2	-0.3	-1.3	-0.5	-0.6	-0.6	-0.4	-0.4
Medication: Seretide 50 evohaler	0.4	0.4	1.5	0.8	0.3	0.9	0.9	-0.3	-0.1	0.5	1.2	-0.5	-0.5	-0.3	-0.4	-0.4
Mean time to correctly identify matches	0.7	1.4	5.1	0.5	0.5	0.2	0.5	-1.1	-1.1	0.4	0.4	-1.4	-1.3	-1.3	-2.1	-2.2
Heart disease (mother)	0.7	0.8	3.9	-1.3	-0.0	-0.7	-0.9	-1.3	-1.0	-2.0	-0.6	-0.7	-0.5	-0.4	-0.0	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	2.5	0.0	0.7	-0.8	-0.3	-0.7	-1.2	-0.2	0.1	-1.1	-1.0	-1.1	-1.4	-1.6
Whole body fat mass	0.4	1.5	3.5	0.1	1.2	-0.5	-0.6	-1.4	-1.1	-1.2	-1.1	-1.8	-1.8	-1.9	-0.8	-0.8
Leg fat mass (right)	0.2	0.9	2.0	0.6	1.1	0.0	0.1	-1.1	-0.8	-0.7	-1.0	-1.3	-1.3	-1.4	-1.0	-1.0
Arm predicted mass (right)	0.3	1.6	5.7	1.7	-0.4	2.4	2.1	0.6	1.0	0.9	-0.4	0.9	0.5	0.5	1.4	1.4
Pulse rate, automated reading	0.6	2.0	12.0	-3.5	-0.5	-0.5	-1.3	-0.6	0.1	-1.1	-0.1	0.0	0.2	0.6	2.1	2.4
Alcohol intake frequency.	0.5	1.1	3.7	-0.7	1.9	-1.5	-1.4	-1.0	-1.9	-0.8	-0.2	-0.5	-0.4	-0.3	-0.7	-0.5
Comparative height size at age 10	1.1	6.1	11.2	0.0	-2.3	2.8	2.4	2.5	2.7	2.1	1.1	2.6	2.4	2.6	3.3	3.2
Number of full sisters	0.3	0.4	1.8	-1.4	-0.4	-0.2	-0.4	0.1	-0.3	-0.1	-1.2	0.3	0.3	0.4	0.5	0.5
Suffer from ‘nerves’	8.9	13.9	23.6	0.3	3.6	-3.6	-3.4	-4.0	-4.3	-2.8	-0.8	-4.3	-4.2	-4.3	-4.9	-4.8
Overall health rating	1.0	2.2	5.5	-0.5	1.4	-1.9	-1.4	-1.0	-2.0	-0.9	0.5	-1.2	-0.8	-1.0	-2.3	-2.3
Chest pain or discomfort	0.1	0.2	0.5	0.3	0.3	0.3	0.5	-0.1	-0.1	0.2	0.6	0.7	0.6	0.6	-0.3	-0.3
Had major operations	0.3	0.3	2.5	-0.4	0.6	-0.4	-0.5	0.3	0.3	-0.1	1.6	-0.0	-0.1	-0.2	-0.4	-0.5
Age at last live birth	0.3	0.5	1.0	-1.0	-0.1	0.5	0.5	-0.0	0.5	0.2	-0.2	1.0	0.9	1.0	0.7	0.8
Family relationship satisfaction	0.2	0.2	0.9	-0.9	0.9	0.1	-0.2	-0.2	-0.2	0.2	0.0	-0.6	-0.4	-0.3	0.5	0.6
Leg pain on walking	0.4	0.5	2.0	1.4	-0.0	0.9	0.9	0.4	1.1	0.8	-0.7	0.2	0.2	-0.0	0.2	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.3	1.5	1.1	0.6	0.6	0.1	0.2	0.4	1.4	0.4	0.2	0.1	-0.2	-0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.2	0.1	-0.6	0.5	0.8	0.2	0.7	0.5	1.1	-0.0	-0.2	-0.3	-0.7	-0.7
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.4	0.1	-0.6	-0.1	-0.2	-0.5	-0.0	-0.2	0.5	-0.3	-0.3	-0.1	-0.1	-0.0
Medication: Aspirin	0.3	0.3	0.9	0.7	-0.5	0.6	0.9	0.6	0.2	0.8	-0.0	0.5	0.6	0.5	-0.5	-0.6
Supplements: Vitamin C	2.9	3.4	7.3	0.7	-1.9	2.0	2.2	2.5	2.7	2.6	0.9	1.6	1.4	1.3	1.3	1.0
Knee pain experienced in last month	1.1	1.7	4.9	2.2	-0.8	1.6	1.7	1.5	2.0	1.8	1.3	0.6	0.3	-0.1	0.3	0.1
Hypertension (Self-reported)	0.6	1.5	3.8	1.0	1.2	-0.6	-0.4	-1.5	-1.9	-0.9	-1.3	-1.2	-1.0	-1.1	-1.7	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.9	0.4	1.0	-0.1	-0.5	-0.9	0.2	-0.3	-0.4	-1.2	-1.4	-1.4	-0.7	-0.6
Illnesses of father: Heart disease	1.4	2.0	6.2	-2.0	0.8	-1.9	-2.5	-1.6	-1.2	-2.1	-1.2	-0.8	-0.5	-0.3	0.2	0.4
Illnesses of siblings: Diabetes	0.5	0.6	1.2	0.0	1.0	-0.7	-0.5	-1.1	-0.7	-0.8	-0.7	-0.6	-0.7	-0.8	-0.8	-0.8
Smoking status: Previous	0.8	1.2	2.5	1.2	-1.3	1.6	1.4	0.8	1.6	1.0	-0.1	0.9	0.7	0.7	1.0	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.9	-1.4	-0.3	-0.6	-1.0	0.0	-0.2	-1.0	0.2	0.4	0.2	0.4	1.2	1.2
Whole body fat-free mass	0.2	1.1	4.5	1.3	-0.1	2.1	1.8	0.3	0.7	0.6	-0.5	0.5	0.1	0.2	1.4	1.4
Leg fat-free mass (right)	0.1	0.4	1.2	0.6	0.5	1.1	0.7	-0.7	-0.3	-0.5	-0.9	-0.4	-0.7	-0.6	0.6	0.6
Arm fat percentage (left)	0.9	3.6	7.1	-0.5	1.7	-1.4	-1.4	-2.0	-2.1	-1.7	-0.9	-2.6	-2.6	-2.7	-1.8	-1.8
Average weekly red wine intake	0.7	1.1	3.2	0.6	-1.5	1.4	0.9	0.7	0.7	0.7	-0.4	0.3	0.3	0.5	1.8	1.7
Handedness (chirality/laterality): Left-handed	1.1	1.4	3.9	1.1	-1.0	0.2	0.6	1.6	0.1	1.2	-0.5	1.9	2.0	1.8	0.4	0.3
Mood swings	1.4	2.6	6.8	2.5	1.9	-0.6	-0.2	-1.0	-1.1	0.3	-0.2	-1.5	-1.5	-1.7	-2.6	-2.6
Loneliness, isolation	0.3	0.4	2.5	0.8	1.1	-0.2	-0.2	-0.0	-0.5	0.4	1.6	-0.5	-0.4	-0.5	-0.2	-0.1
Long-standing illness, disability or infirmity	0.2	0.3	1.4	-0.1	0.4	-0.1	-0.1	-0.8	-1.2	-0.7	-0.2	-0.5	-0.5	-0.3	-0.6	-0.6
Ever had bowel cancer screening	1.5	1.7	3.5	-1.3	0.7	-1.6	-1.4	-1.5	-1.9	-1.5	-0.6	-1.2	-0.8	-0.7	-1.5	-1.4
Diabetes diagnosed by doctor	0.2	0.3	1.0	0.4	1.0	0.6	0.5	-0.5	0.1	0.0	0.5	-0.8	-0.8	-0.6	-0.6	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	4.7	-2.2	0.2	-1.5	-1.9	-0.9	-1.4	-1.4	-0.8	-1.0	-0.8	-0.7	0.1	0.2
Friendships satisfaction	0.2	0.2	0.6	0.4	0.7	-0.0	-0.0	-0.6	-0.8	0.4	0.5	-0.1	-0.0	0.0	-0.7	-0.6
Qualifications: nursing, teaching	0.9	1.3	2.7	-1.3	1.6	-1.2	-1.1	-1.4	-1.5	-1.6	-1.0	-0.7	-0.7	-0.7	-0.8	-0.6
Commuting to job workplace: Walk	1.5	1.6	3.9	1.3	0.5	1.7	1.4	0.9	0.9	1.3	1.1	1.1	0.9	0.9	1.7	2.0
Eye problems/disorders: Cataract	2.3	2.7	7.5	1.1	-0.4	2.3	2.4	1.6	2.2	2.7	2.0	1.0	0.7	0.7	0.9	0.9
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	4.1	-0.3	1.2	-1.3	-1.4	-1.3	-2.0	-1.2	-0.9	-0.6	-0.5	-0.5	-0.7	-0.5
Medication for cholesterol	0.5	0.8	2.0	0.6	0.0	0.7	0.7	0.6	0.6	0.3	0.2	1.4	1.3	1.4	0.9	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	6.1	2.1	0.6	0.4	0.8	1.1	1.0	2.1	2.5	0.3	0.4	0.0	-0.5	-0.4
Back pain experienced in last month	1.3	1.9	4.2	0.8	-0.9	1.4	1.5	1.2	2.0	1.0	1.0	1.8	1.7	1.7	0.9	1.0
Mineral and other dietary supplements	1.4	1.9	4.9	-0.9	0.8	-1.7	-1.8	-1.2	-2.2	-1.7	-0.2	-1.5	-1.5	-1.4	-0.9	-1.0
Breast cancer (self-reported)	0.2	0.3	1.6	0.0	-1.0	-0.1	-0.3	-0.3	0.4	-0.5	-1.3	-0.1	-0.1	-0.1	-0.2	-0.1
Asthma (self-reported)	1.4	2.8	5.5	1.2	2.3	-0.7	-0.6	-1.5	-2.4	-0.1	-1.1	-2.0	-1.9	-2.0	-2.0	-1.9
Osteoporosis (self-reported)	0.6	0.7	2.8	-0.6	-1.1	-0.7	-0.5	-0.3	-0.0	-0.7	-0.4	-0.7	-0.5	-0.6	-1.4	-1.7
Osteoarthritis (self-reported)	0.8	1.0	3.7	0.2	-1.9	0.7	0.8	1.8	0.6	1.0	0.7	1.0	1.2	1.1	0.5	0.4
Medication: Aspirin	0.2	0.3	0.9	0.6	-0.6	0.6	0.9	0.5	0.0	0.7	0.0	0.3	0.5	0.4	-0.6	-0.6
Medication: Gliclazide	2.0	2.2	4.6	0.1	1.8	-0.6	-0.8	-1.9	-1.6	-1.4	1.5	-2.1	-2.1	-1.8	-1.0	-1.0
Illnesses of father: None of the above (group 1)	0.9	1.1	2.9	-0.0	-1.1	0.7	1.1	1.7	0.6	1.5	1.0	1.3	1.2	1.2	0.4	0.2
Smoking status: Current	3.7	5.9	12.6	-0.4	-3.5	2.0	1.9	2.8	3.4	1.9	0.6	2.6	2.5	2.4	2.7	2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	3.2	-0.5	-0.2	-0.5	-0.6	-1.1	-0.6	-1.8	-0.8	0.6	0.6	0.6	-0.1	0.1
Whole body water mass	0.2	1.2	4.7	1.3	-0.2	2.2	1.8	0.4	0.8	0.7	-0.5	0.5	0.2	0.3	1.4	1.4
Leg predicted mass (right)	0.1	0.4	1.3	0.7	0.5	1.1	0.8	-0.6	-0.2	-0.4	-0.9	-0.4	-0.7	-0.6	0.6	0.6
Arm fat mass (left)	0.4	1.7	4.2	0.3	1.1	-0.3	-0.4	-1.5	-1.2	-1.2	-1.1	-1.9	-2.0	-2.1	-1.0	-1.0
Number of self-reported non-cancer illnesses	2.1	3.6	8.2	0.5	1.4	-1.1	-1.0	-2.0	-2.5	-1.1	0.0	-2.3	-2.2	-2.2	-2.9	-2.8
Average weekly champagne plus white wine intake	0.1	0.2	1.1	0.1	-0.1	0.7	0.8	0.2	-0.0	1.1	-0.0	0.1	0.0	0.2	-0.2	-0.2
Miserableness	2.2	3.9	6.8	1.5	2.5	-1.5	-1.3	-1.9	-1.9	-0.4	-0.4	-2.5	-2.3	-2.4	-2.6	-2.5
Guilty feelings	0.2	0.4	1.8	1.0	-0.3	0.2	0.3	0.9	0.1	1.3	0.8	0.5	0.4	0.2	0.0	0.0
Wears glasses or contact lenses	0.8	0.9	1.7	0.8	0.8	-0.6	-0.6	-1.0	-1.0	-0.7	-1.0	-1.1	-1.1	-1.3	-1.2	-1.1
Ever taken oral contraceptive pill	1.8	2.0	3.9	0.3	-1.3	0.7	0.7	1.6	1.5	1.1	-0.1	1.9	2.0	1.9	1.7	1.7
Hearing aid user	1.1	1.3	2.2	-0.7	1.3	-1.4	-1.3	-0.7	-1.5	-0.4	0.0	-1.4	-1.0	-1.1	-1.4	-1.4
Mother’s age at death	0.6	0.7	1.5	-0.7	0.3	-1.0	-0.8	-0.5	-0.4	-0.1	-1.0	-1.2	-1.0	-0.9	-1.1	-1.1
Financial situation satisfaction	0.5	0.6	1.2	0.5	0.6	-0.9	-0.8	-0.9	-1.0	-0.7	-0.6	-0.4	-0.3	-0.4	-1.1	-1.1
Tinnitus: Yes, now most or all of the time	2.8	3.3	7.0	-1.3	0.8	-1.6	-1.7	-2.1	-2.1	-1.8	-2.6	-2.1	-1.9	-1.7	-1.6	-1.5
Commuting to job workplace: Public transport	1.9	2.3	5.0	-0.6	-1.2	0.6	0.5	1.7	1.0	0.9	-1.0	2.1	2.2	2.2	2.0	1.9
Eye problems/disorders: Glaucoma	0.2	0.2	1.0	-0.8	-0.1	0.0	0.1	-0.5	-0.4	-0.5	-1.0	-0.1	-0.2	-0.1	-0.5	-0.5
Medication: Blood pressure	0.4	0.8	1.6	-1.1	0.0	-1.1	-1.2	-0.8	-1.3	-1.2	-0.6	-0.9	-0.6	-0.6	-0.6	-0.5
Pain type(s) experienced in last month: Hip pain	3.5	4.4	9.6	2.4	-2.2	2.9	3.0	2.2	3.1	3.0	1.2	1.5	0.8	0.6	0.9	0.8
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.0	0.9	-0.4	1.3	1.4	0.5	1.7	1.1	0.8	0.7	0.5	0.5	0.3	0.4
High cholesterol (Self-reported)	0.8	1.4	3.4	-0.6	0.3	-1.8	-1.7	-1.2	-1.9	-1.3	-0.2	-0.9	-0.7	-0.6	-1.2	-1.3
Medication: Bendroflumethiazide	0.6	1.0	2.7	0.7	1.7	-0.6	-0.4	-1.2	-1.1	-0.8	-0.1	-0.4	-0.3	-0.5	-1.6	-1.4
Medication: Paracetamol	0.3	0.5	1.1	-0.1	0.5	-1.1	-0.8	-0.9	-0.6	-0.9	0.7	-0.5	-0.3	-0.5	-1.0	-0.9
Medication: Lisinopril	0.5	0.7	2.2	0.1	-0.8	-0.7	-0.5	-0.5	-1.5	-0.6	-1.1	-0.2	-0.1	-0.1	-1.3	-1.4
Medication: Atorvastatin	0.3	0.4	2.3	-0.2	-0.5	-0.2	0.1	0.0	-0.0	-0.4	-1.5	0.7	0.9	0.8	-0.3	-0.3
Illnesses of father: High blood pressure	0.9	1.2	2.6	-0.3	1.1	-1.1	-1.0	-1.4	-1.0	-1.6	-1.6	-0.9	-0.8	-0.8	-0.9	-0.7
Alcohol drinker status: Never	0.3	0.3	1.7	1.0	1.3	-0.0	0.1	0.2	-0.6	0.6	-0.3	0.5	0.6	0.5	-0.2	-0.1
Ever smoked	0.6	1.0	2.8	0.5	-1.7	0.6	0.3	0.8	1.4	0.5	-0.4	0.9	0.9	0.8	1.5	1.6
Basal metabolic rate	0.1	0.7	2.9	1.1	0.1	1.7	1.3	-0.0	0.4	0.2	-0.6	0.1	-0.2	-0.2	1.1	1.2
Leg fat percentage (left)	0.5	1.8	4.0	0.6	1.6	-0.7	-0.5	-1.2	-1.0	-0.7	-0.7	-2.0	-1.8	-2.0	-1.5	-1.6
Arm fat-free mass (left)	0.3	1.6	5.7	1.9	-0.2	2.4	2.1	0.5	1.0	0.9	-0.8	0.8	0.4	0.4	1.2	1.3
Number of operations (self-reported)	0.8	1.1	4.7	-1.8	1.0	-1.3	-1.4	-0.2	-0.5	-1.0	2.2	0.2	0.4	0.4	0.5	0.5
Average weekly beer plus cider intake	1.9	2.8	9.0	-3.0	-0.0	-2.4	-2.2	-1.3	-1.2	-2.8	-1.1	-1.0	-0.6	-0.6	-1.1	-1.2
Irritability	0.6	1.0	2.4	1.6	1.1	-0.6	-0.3	-0.3	-0.9	0.5	1.1	-0.9	-0.8	-1.0	-1.6	-1.5
Risk taking	2.9	4.2	9.4	1.1	-1.6	2.1	2.1	2.5	3.1	2.7	2.1	1.9	1.7	1.7	1.8	1.6
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.8	0.2	-1.1	0.5	0.6	1.1	0.8	0.8	1.7	1.1	1.2	1.2	1.3	1.2
Fractured/broken bones in last 5 years	0.1	0.2	0.7	-0.8	-0.3	-0.3	-0.5	-0.0	-0.3	-0.1	0.9	-0.3	-0.2	0.1	0.2	0.2
Age started oral contraceptive pill	0.3	0.4	2.0	-0.6	-0.3	-0.2	0.0	-0.2	-0.7	0.1	1.4	-0.4	-0.2	-0.1	-0.8	-0.9
Diastolic blood pressure, automated reading	0.1	0.3	1.2	-0.8	0.8	-0.3	-0.0	0.2	-0.4	0.4	-1.1	-0.1	0.2	0.2	0.6	0.9
Ever depressed for a whole week	1.0	1.3	4.0	1.2	2.0	0.2	0.1	-1.3	-0.3	-0.3	-0.5	-1.2	-1.4	-1.4	-1.4	-1.4
Unable to work because of sickness or disability	4.7	6.1	10.6	0.7	-2.5	1.8	2.0	3.2	2.9	2.5	2.0	3.0	3.0	2.9	2.2	2.0
Commuting to job workplace: Cycle	0.2	0.2	0.9	-0.1	-0.6	-0.4	-0.4	0.5	1.0	0.1	-0.4	-0.6	-0.4	-0.6	-0.1	-0.2
Myopia	0.5	0.8	3.0	1.5	1.7	0.3	0.3	-0.6	-1.4	0.1	-0.6	-0.5	-0.7	-0.8	-0.6	-0.4
Vascular/heart problems diagnosed by doctor	1.0	2.7	6.6	-1.4	-1.5	0.7	0.3	1.6	2.1	1.0	1.6	1.5	1.4	1.6	2.6	2.5
Cholesterol lowering medication	0.7	1.0	2.1	-0.5	0.7	-0.9	-1.1	-1.1	-1.1	-0.7	-0.0	-1.4	-1.4	-1.3	-0.9	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.7	0.5	0.3	-0.5	-0.6	-0.9	-0.4	-0.7	-0.7	-1.1	-1.2	-1.3	-0.7	-0.7
Pain experienced in last month	0.4	0.6	2.7	-1.6	-0.5	-0.7	-1.0	-0.5	-0.8	-1.1	-0.2	-0.2	-0.2	0.3	0.9	0.9
Supplements: Calcium	0.2	0.3	0.6	-0.2	-0.8	0.4	0.5	0.6	0.6	0.5	0.4	0.5	0.4	0.3	0.5	0.6
Basal cell carcinoma (self-reported)	0.9	1.1	4.2	0.8	2.1	0.1	0.2	-1.4	-1.7	-0.4	0.5	-0.7	-0.9	-0.8	-1.0	-0.7
Heart attack/myocardial infarction (self-reported)	1.2	1.5	7.1	1.7	-0.4	0.3	0.7	-0.4	-0.2	0.2	-1.0	-0.6	-0.8	-1.0	-2.4	-2.7
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	4.0	0.7	1.6	-1.1	-1.1	-1.3	-1.7	-0.5	1.4	-1.8	-1.8	-1.9	-2.0	-2.0
Heart disease (siblings)	0.3	0.4	0.8	0.4	-0.8	0.6	0.8	0.7	0.9	0.9	-0.2	0.4	0.4	0.4	0.7	0.5
Alcohol drinker status: Previous	1.9	2.2	5.0	-0.3	-2.2	1.1	0.9	1.6	1.4	1.0	0.5	1.3	1.4	1.5	2.1	2.1
Pack years of smoking	0.3	0.4	0.9	0.9	0.5	0.9	1.0	0.4	0.8	0.9	0.9	0.1	-0.0	-0.2	-0.4	-0.3
Impedance of whole body	0.4	2.2	11.0	-3.3	-1.4	-2.0	-2.1	0.5	-0.1	-0.8	0.9	0.4	0.9	1.1	1.2	1.2
Leg fat mass (left)	0.3	1.0	2.4	0.7	1.2	-0.0	0.0	-1.1	-0.7	-0.7	-1.0	-1.4	-1.4	-1.5	-1.0	-1.0
Arm predicted mass (left)	0.3	1.8	6.3	1.9	-0.4	2.5	2.2	0.6	1.1	1.0	-0.7	0.8	0.5	0.5	1.4	1.4