Hub : Genes

BAIAP2L1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0920	0.0320	7.6e-04	0.073	NA	0.064	NA	0.056	1.3e-06	NA	5.8e-06	NA	2.1e-05
2	GTEx	Adipose Visceral Omentum	0.3070	0.0780	1.6e-05	0.001	NA	0.001	NA	0.020	2.9e-01	NA	2.8e-01	NA	3.1e-02
3	GTEx	Skin Not Sun Exposed Suprapubic	0.0960	0.0350	2.1e-04	0.125	NA	0.124	NA	0.125	2.3e-07	NA	2.7e-07	NA	2.3e-07
4	GTEx	Skin Sun Exposed Lower leg	0.1090	0.0350	7.7e-07	0.065	NA	0.084	NA	0.101	4.5e-06	NA	1.9e-07	NA	1.0e-08
5	GTEx	Testis	0.3250	0.0740	1.4e-05	0.265	NA	0.178	NA	0.256	3.8e-12	NA	2.5e-08	NA	9.6e-12
6	GTEx	Thyroid	0.0890	0.0280	2.0e-06	0.055	NA	0.071	NA	0.071	4.6e-05	NA	3.9e-06	NA	4.1e-06
7	NTR	Blood	0.0223	0.0084	1.0e-04	0.015	0.011	0.010	0.011	0.012	1.2e-05	1.5e-04	2.5e-04	0.00011	7.0e-05
8	ROSMAP	Brain Pre-frontal Cortex	0.0425	0.0157	4.3e-06	0.039	0.016	0.036	0.015	0.036	7.5e-06	3.5e-03	1.8e-05	0.00380	1.9e-05
9	TCGA	Breast Invasive Carcinoma	0.0413	0.0234	7.9e-08	0.031	0.030	0.024	NA	0.025	3.9e-07	7.6e-07	9.5e-06	NA	4.9e-06
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0795	0.0455	5.8e-06	0.057	0.063	0.059	NA	0.057	5.0e-07	1.2e-07	3.1e-07	NA	4.7e-07
11	TCGA	Pancreatic Adenocarcinoma	0.1070	0.0840	2.1e-03	0.037	0.032	0.028	NA	0.022	1.1e-02	1.7e-02	2.4e-02	NA	3.9e-02
12	TCGA	Thyroid Carcinoma	0.1140	0.0620	9.7e-06	0.048	0.059	0.049	NA	0.050	1.9e-05	1.9e-06	1.6e-05	NA	1.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	2.1	3.3	6.2	1.4	0.9	2.4	2.2	1.1	1.9	-1.3	2.5	-1.3	2.4	1.8	1.5
Bipolar Disorder or Schizophrenia	0.8	2.0	6.2	-0.9	-0.6	1.8	1.8	2.3	0.4	-2.0	0.8	-0.7	0.3	0.1	2.5
Depressed Affect (Nagel 2018)	1.7	3.6	5.8	-1.4	-1.6	-2.3	-2.2	-1.3	-2.4	1.2	-2.4	2.0	-1.6	-2.1	-1.7
Depression (Nagel 2018)	0.6	0.9	3.6	-0.8	-1.9	-1.1	-1.3	-0.3	-0.6	0.4	-1.1	0.8	-0.7	-0.7	-0.7
Intelligence (Savage-Jansen 2018)	0.2	0.8	2.1	-0.6	0.6	0.5	1.2	1.4	0.2	-1.4	1.0	-0.5	-0.1	0.3	1.2
Neuroticism (Nagel 2018)	5.8	13.6	22.5	-3.0	-2.5	-4.7	-4.3	-2.3	-4.6	2.4	-4.5	4.2	-3.1	-4.2	-3.1
Schizophrenia (2018)	1.0	2.0	5.0	-2.2	-1.6	0.4	0.5	2.1	-1.1	-1.5	-1.0	0.1	-1.6	-1.3	2.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.9	-0.6	0.7	0.3	0.5	0.9	0.1	-0.8	-0.1	-0.2	-0.1	-0.3	1.0
Worry (Nagel 2018)	6.5	13.7	22.9	-2.5	-1.7	-4.8	-4.4	-2.9	-4.4	3.4	-4.3	4.0	-3.0	-3.9	-3.8
Alzheimer’s Disease (in mother)	0.1	0.1	0.4	0.4	-0.3	-0.3	-0.5	-0.1	0.1	-0.0	0.1	0.3	0.7	0.5	-0.5
Alzheimer’s Disease (in father)	0.5	0.6	1.1	0.4	-0.2	0.7	1.0	0.6	1.0	-1.0	0.9	-0.2	1.0	0.5	0.7
Alzheimer’s Disease (including proxy)	0.2	0.2	1.0	0.8	-0.2	-0.2	-0.3	-0.2	0.5	-0.2	0.3	0.4	1.0	0.4	-0.5
Crohns Disease (2017)	0.1	0.3	1.0	0.5	0.6	0.7	0.6	0.0	0.0	-0.1	0.8	-1.0	0.2	0.5	0.6
Irritable Bowel Disease (IBD)	0.3	0.7	1.4	-0.3	-0.3	-1.0	-1.2	-0.7	-0.9	0.6	-1.0	0.9	-0.9	-1.0	-0.6
Ulcerative Colitis (UC)	1.7	3.1	5.7	-0.8	-1.1	-2.2	-2.4	-1.3	-1.6	1.2	-2.3	2.1	-1.6	-2.0	-1.8
Major Depression (MDD)	0.3	0.4	1.1	-0.5	-0.7	-0.8	-0.6	-0.5	-0.8	0.4	-0.5	0.3	-0.9	-0.2	-1.1
Reaction Time	0.9	1.7	5.8	-0.8	2.1	-1.5	-1.1	-0.3	-1.2	-0.2	-1.3	2.4	0.2	-1.6	-0.7
Verbal and Numeric Reasoning (VNR)	0.6	1.3	4.2	-0.8	0.5	0.7	1.5	2.0	0.2	-2.0	0.9	-0.3	0.1	0.4	1.7
Breast Cancer	3.8	9.2	21.9	4.2	4.7	2.1	1.6	-0.2	3.4	0.5	3.8	-1.8	4.5	3.7	-0.6
Ovarian Cancer	2.4	3.2	6.6	2.0	0.8	2.2	2.0	0.2	1.9	-0.4	2.5	-2.3	1.9	2.6	0.2
Prostate Cancer	18.0	25.3	43.8	2.4	1.4	6.2	6.6	4.9	5.4	-5.0	6.3	-5.2	3.9	4.8	5.7
Age at First Birth	0.1	0.1	0.4	0.4	0.5	0.2	0.4	0.1	-0.3	0.1	0.5	-0.3	0.6	0.4	0.0
Bipolar Disorder (2011)	0.9	0.8	1.7	0.1	0.1	1.2	1.3	0.8	1.0	-1.0	1.2	-1.0	0.4	0.9	1.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.8	-0.5	-0.1	0.3	0.3	0.9	-0.1	-0.8	-0.3	0.1	0.1	-0.2	0.7
Coronary Artery Disease (CAD)	0.3	0.4	0.9	-0.3	0.2	-0.9	-0.8	-0.4	-0.2	0.5	-0.2	1.0	-0.1	-0.5	-1.0
Crohns Disease (2012)	0.3	0.5	1.6	-0.1	-0.1	0.8	0.8	0.8	0.4	-0.7	0.8	-1.0	-0.0	0.4	1.3
Mean Putamen Volume	0.4	0.5	1.6	-0.2	-1.3	0.0	0.2	-0.9	-0.9	0.4	-0.6	-0.8	-1.1	0.1	-0.7
Fasting Glucose	3.2	3.8	6.7	-1.4	-1.7	-2.6	-2.5	-1.6	-1.3	1.3	-2.4	2.1	-1.8	-2.3	-1.7
HbA1C	0.5	0.6	2.1	-0.1	0.3	-1.2	-0.3	-1.1	-0.3	1.4	-0.8	0.3	-0.5	-0.6	-0.7
HDL Cholesterol	0.3	0.5	2.9	0.8	1.7	0.6	-0.1	0.1	0.9	0.2	0.5	-0.4	0.7	0.7	0.1
LDL Cholesterol	3.1	4.9	18.1	1.8	0.8	-1.6	-2.1	-4.3	-0.9	3.7	-1.1	-0.1	-0.0	0.1	-3.7
Lupus	2.0	3.1	6.2	2.3	1.0	2.3	1.5	-0.3	2.1	0.3	2.0	-2.5	1.8	2.2	0.5
Neuroticism (2016)	1.5	2.2	5.2	-0.3	-1.2	-2.1	-1.6	-1.6	-1.5	1.3	-1.3	1.4	-1.2	-1.0	-2.3
Primary Biliary Cirrhosis	0.2	0.3	1.5	-0.3	-1.2	0.2	0.7	0.7	0.3	-0.6	0.2	-0.4	-0.3	-0.0	0.8
Rheumatoid Arthritis	0.3	0.5	1.4	0.1	-1.2	-0.9	-0.9	-0.7	-0.4	0.9	-0.6	0.3	-0.7	-0.5	-0.4
Schizophrenia (2014)	1.0	2.1	7.1	-1.7	-0.5	1.3	1.6	2.4	-0.3	-2.1	0.2	-0.6	-0.3	-0.4	2.7
Triglycerides	0.3	0.5	1.2	-0.0	-1.1	-0.8	-0.7	-1.1	-0.1	1.0	-0.5	0.9	0.0	-0.6	-0.7
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.8	0.0	-0.4	0.4	0.5	-0.6	0.2	0.4	0.4	-0.9	-0.9	0.5	-0.8
Ulcerative Colitis	0.7	1.0	2.8	-1.0	-0.6	-1.3	-0.9	-0.0	-0.9	-0.3	-1.3	1.7	-0.5	-1.4	-0.2
Blood Eosinophil Count	1.0	8.1	14.0	-3.2	-3.7	-3.0	-2.8	-0.9	-3.0	1.2	-3.4	2.7	-3.6	-3.5	-1.1
Blood Platelet Count	0.2	2.2	5.9	-0.3	-1.3	-1.4	-1.2	-2.4	-1.2	2.1	-1.2	0.3	-1.8	-1.0	-1.9
Blood Red Count	0.9	8.7	20.9	4.6	4.3	0.9	-0.2	-3.3	1.4	3.3	2.2	-1.5	3.1	3.1	-3.8
Blood White Count	1.1	8.1	18.4	0.5	-1.6	3.8	4.2	2.2	2.3	-2.5	2.6	-4.3	0.2	2.4	3.9
Heel T-Score	1.3	10.3	36.8	-3.1	0.0	2.3	3.0	5.3	1.1	-5.6	0.7	-0.1	-0.1	-0.7	6.1
BMI	0.4	2.2	5.3	-2.3	-2.1	-0.7	-0.0	1.8	-1.0	-1.7	-0.9	1.6	-0.8	-1.8	1.4
Height	0.3	6.7	15.3	2.8	3.1	3.1	2.4	-0.1	1.7	-0.2	2.9	-3.9	2.3	3.8	0.1
Waist Hip Ratio (WHR)	0.7	3.1	8.8	-0.2	-1.5	-1.1	-1.2	-3.0	-1.4	2.3	-1.7	-0.8	-2.6	-0.5	-2.5
Systolic Blood Pressure	0.6	3.2	6.2	1.4	2.1	2.3	2.5	0.9	1.8	-1.5	2.0	-1.6	2.0	1.6	1.0
Smoking Status	3.2	7.6	13.5	1.6	1.3	3.4	3.6	1.8	3.7	-2.2	3.4	-3.1	2.3	2.8	2.7
Allergy or Eczema	3.3	8.7	14.6	-2.8	-1.8	-3.5	-3.4	-1.1	-3.8	1.6	-3.8	3.2	-3.2	-3.5	-1.9
Cardiovascular Disease	0.6	2.1	4.3	-0.1	-0.1	-1.6	-1.5	-2.1	-1.5	1.8	-1.5	1.3	-0.6	-1.3	-2.1
Hypothyroidism (self reported)	0.5	1.3	3.0	1.7	1.1	0.9	-0.1	-1.4	0.9	0.9	0.5	-1.2	1.3	1.4	-1.0
Respiratory disease	1.5	3.3	10.8	-1.5	-3.3	-2.2	-1.4	-0.7	-2.0	0.6	-2.0	1.7	-1.7	-1.9	-1.1
Type 2 Diabetes (T2D) (2018)	0.7	1.4	4.3	1.3	1.7	-0.4	-0.1	-2.0	-0.2	1.2	0.3	-0.1	1.0	0.6	-2.1
Lung FEV1/FVC ratio	0.3	1.4	3.6	0.6	1.9	1.5	1.1	0.3	0.7	-0.5	0.9	-1.9	0.4	1.1	1.4
Lung FVC	0.5	2.5	6.2	2.5	0.5	0.9	0.6	-1.4	1.0	1.6	1.6	-1.4	1.6	2.2	-2.2
Neuroticism	2.1	5.1	8.8	-2.1	-2.0	-3.0	-2.3	-1.1	-2.9	1.1	-2.7	2.4	-2.2	-2.5	-1.9
Chronotype (morning person)	3.5	8.1	13.0	2.2	3.0	3.6	3.3	1.7	3.1	-1.6	3.4	-3.1	3.0	3.2	2.1
Hair Pigment	0.1	2.2	4.2	-1.1	1.0	-1.8	-2.1	-1.0	-1.4	1.0	-1.9	1.9	-1.1	-1.9	-0.9
Tanning	0.6	6.9	12.8	0.9	-0.5	2.9	3.6	2.7	2.7	-2.8	3.2	-3.0	1.3	2.8	3.1
Hand grip strength (left)	2.1	5.5	8.6	1.6	2.5	2.7	2.7	1.3	2.9	-1.6	2.9	-2.1	2.3	2.3	2.3
Number of treatments/medications taken	1.3	2.3	4.5	-1.3	-1.3	-2.0	-1.8	-0.6	-2.0	0.8	-1.6	2.1	-0.8	-1.7	-1.3
Average weekly spirits intake	1.0	1.2	2.5	0.4	-0.5	1.1	0.9	1.4	1.1	-1.2	1.3	-0.3	1.5	0.8	1.6
Sensitivity / hurt feelings	4.1	7.1	13.4	-2.5	-2.5	-3.1	-2.8	-1.2	-3.3	1.0	-3.7	2.8	-2.8	-3.2	-1.6
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.5	-0.8	-1.0	-1.5	-1.6	-0.3	-0.4	0.4	-1.4	1.5	-0.6	-1.0	-1.0
Hearing difficulty/problems: Yes	0.4	0.5	1.3	-0.7	-0.7	-0.6	-1.0	-0.5	-0.9	0.6	-1.1	0.5	-0.6	-0.9	-0.2
Relative age of first facial hair	0.4	0.9	2.2	0.5	-1.3	-0.6	-0.8	-1.4	-0.8	1.5	-0.5	-0.1	-0.7	-0.0	-1.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.6	0.8	1.3	1.1	0.7	0.3	0.4	-0.3	0.7	-1.0	0.6	1.3	-0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.4	-0.1	-0.8	0.6	0.9	0.5	0.2	-0.5	0.4	-1.0	-0.3	0.3	1.2
Ever had hysterectomy (womb removed)	0.4	0.5	1.6	-1.1	-1.3	-0.2	0.2	0.3	-0.8	-0.6	-0.4	0.1	-0.8	-0.7	0.8
Systolic blood pressure, automated reading	0.5	1.6	2.9	0.1	1.7	1.4	1.3	1.6	0.7	-1.6	1.0	-0.1	1.7	0.4	1.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.9	-1.2	-1.0	0.7	1.2	1.4	0.5	-1.3	0.6	-0.5	-0.3	-0.2	1.3
Angina	0.7	0.9	1.9	-0.3	-1.0	-1.4	-1.0	-0.9	-0.9	1.0	-0.8	1.1	-0.6	-1.0	-0.7
Medication for hormone replacement therapy	0.2	0.2	0.5	-0.7	-0.2	-0.6	0.0	0.2	0.1	-0.4	-0.3	0.5	-0.6	-0.7	0.3
Vitamin and mineral supplements	4.4	6.0	8.6	-1.3	-2.3	-2.5	-2.5	-2.7	-2.9	2.6	-2.9	1.4	-2.9	-2.4	-2.5
Supplements: Zinc	1.6	1.8	5.1	1.5	2.3	1.6	0.8	0.3	1.4	-0.0	1.4	-1.1	1.7	1.5	0.3
Medication: Co-codamol	0.8	1.0	3.8	-0.5	-1.2	0.8	1.0	1.4	-0.1	-1.2	0.3	-0.8	-0.4	-0.0	1.9
Medication: Metformin	1.0	1.4	4.6	0.2	-0.5	-1.2	-1.0	-2.1	-1.1	1.6	-0.5	0.9	0.4	-0.3	-2.1
Diabetes (father)	0.3	0.4	1.7	-0.7	-0.1	0.1	0.3	1.0	0.4	-1.3	-0.3	0.5	-0.0	-0.3	0.8
Diabetes (mother)	1.1	1.4	3.1	-0.2	-0.6	-1.3	-1.3	-1.7	-0.9	1.6	-1.2	1.1	-0.2	-0.9	-1.8
Severe depression (siblings)	0.8	0.8	1.6	-0.7	1.0	-1.0	-1.1	-0.7	-0.8	0.8	-1.2	0.8	-0.7	-0.7	-1.2
Pack years adult smoking proportion	0.2	0.4	0.8	0.5	-0.9	0.4	0.9	0.6	0.2	-0.9	0.7	0.0	0.6	0.1	0.6
Impedance of leg (right)	0.6	2.8	8.6	2.9	1.7	1.0	0.3	-1.9	1.6	1.3	1.2	-1.5	1.7	2.0	-1.6
Leg fat-free mass (left)	0.3	1.4	3.7	-1.1	-0.1	1.1	1.6	1.9	0.2	-1.7	0.9	-0.9	-0.1	0.3	1.9
Trunk fat percentage	0.3	1.2	4.0	-1.1	-0.9	-1.0	-1.2	-0.7	-2.0	0.8	-1.2	0.9	-0.8	-1.2	-0.7
Hand grip strength (right)	1.8	4.8	6.9	1.4	2.4	2.6	2.5	1.6	2.6	-1.6	2.5	-2.1	1.9	2.0	2.5
Townsend deprivation index at recruitment	0.8	1.1	3.2	0.5	-0.8	0.8	1.1	1.1	1.5	-1.4	1.0	-0.4	0.6	0.6	1.8
Current tobacco smoking	2.5	4.0	11.6	1.5	-0.0	2.1	2.4	1.2	3.4	-1.7	2.4	-1.8	1.9	2.0	1.9
Average weekly fortified wine intake	0.8	0.9	2.6	-1.6	0.3	-0.8	-0.7	0.5	-1.0	-0.4	-1.1	1.4	-0.7	-1.4	0.6
Maternal smoking around birth	1.0	1.4	3.0	-0.2	1.5	0.8	1.7	1.3	1.0	-1.6	1.3	-0.6	0.7	0.5	1.7
Fed-up feelings	0.5	0.8	2.0	-0.5	-1.2	-1.3	-1.0	-0.4	-0.9	0.1	-1.0	1.4	-0.4	-0.9	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.5	-0.3	-1.2	-0.5	-0.7	0.1	0.3	0.3	-0.4	0.4	-0.2	-0.3	-0.5
Relative age voice broke	0.4	0.6	1.9	0.8	-0.7	0.0	-0.1	-1.2	-0.5	1.2	0.2	-0.7	-0.2	0.5	-1.4
Taking other prescription medications	0.3	0.5	2.0	1.0	0.2	0.7	0.4	0.1	0.7	-0.0	0.8	-0.5	1.4	0.9	0.2
Age when periods started (menarche)	0.1	0.2	1.0	-0.1	-0.5	0.7	0.6	1.0	-0.0	-0.6	0.3	-0.3	-0.1	0.3	0.4
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	3.0	-1.4	-1.7	0.6	1.1	1.3	-0.3	-1.4	0.1	-0.5	-1.1	-0.5	1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	-0.1	0.9	0.1	0.6	0.7	0.9	-0.9	0.5	0.4	0.7	0.2	0.6
Tinnitus: Yes, but not now, but have in the past	2.3	2.4	4.8	-1.6	-1.2	-1.8	-1.4	-0.5	-2.2	0.6	-2.2	1.6	-1.7	-1.9	-1.1
Qualifications: CSEs or equivalent	0.1	0.1	0.6	0.2	-0.3	-0.1	-0.2	-0.8	0.2	0.6	-0.4	-0.3	-0.4	-0.2	-0.2
Serious illness, injury or assault to yourself	0.0	0.1	0.2	0.3	0.1	-0.2	-0.2	-0.0	0.4	0.2	0.1	-0.2	-0.2	0.3	0.0
High blood pressure	0.4	1.2	4.0	-0.7	0.3	-1.4	-1.1	-0.4	-1.7	0.4	-1.1	2.0	0.0	-1.5	-0.7
Hayfever, allergic rhinitis or eczema	1.9	4.1	8.6	-1.7	-1.4	-2.5	-2.2	-1.2	-2.9	1.5	-2.4	1.8	-2.3	-2.1	-1.7
Multivitamins +/- minerals	2.7	3.4	5.2	1.2	2.2	1.9	1.8	1.5	2.1	-1.6	2.3	-1.5	2.1	2.0	1.7
Stomach or abdominal pain in last month	0.1	0.2	0.5	-0.5	-0.2	-0.3	-0.5	0.6	0.0	-0.2	-0.4	0.7	0.0	-0.5	0.3
Supplements: Glucosamine	1.2	1.5	5.5	-1.2	-0.2	0.8	1.4	2.4	0.1	-1.8	1.0	-0.2	0.3	0.2	2.1
Diverticular disease/diverticulitis (self-reported)	2.3	2.8	5.4	-0.7	-0.6	-1.9	-1.9	-2.0	-2.3	2.1	-1.6	0.9	-1.4	-1.2	-2.2
Medication: Atenolol	0.7	0.9	2.1	-0.5	-0.4	-1.2	-1.1	-0.9	-1.4	0.9	-0.8	0.9	-0.8	-0.9	-1.0
Medication: Levothyroxine sodium	0.5	0.8	3.1	1.0	0.3	-0.0	-0.5	-1.8	-0.4	1.4	-0.3	-0.5	0.1	0.5	-1.6
Sitting height	1.3	9.4	15.3	2.4	3.5	3.9	3.6	1.3	3.2	-1.6	3.7	-3.9	2.5	3.8	1.6
Chronic bronchitis/emphysema (father)	0.6	0.7	2.3	-0.9	-1.1	0.7	0.7	1.0	-0.3	-1.5	0.1	-0.2	0.2	-0.1	1.5
High blood pressure (mother)	1.5	2.2	6.2	1.1	0.7	-1.7	-1.7	-2.5	-1.0	2.2	-0.6	1.2	0.5	-0.4	-2.1
Body mass index (BMI)	0.7	2.9	8.0	-2.8	-2.2	-1.2	-0.6	1.3	-2.0	-0.9	-1.4	1.9	-1.3	-2.3	1.2
Impedance of leg (left)	0.6	3.1	9.5	3.1	1.7	1.0	0.0	-2.1	1.6	1.7	1.1	-1.6	1.6	2.1	-2.0
Leg predicted mass (left)	0.3	1.4	3.6	-1.1	-0.0	1.1	1.6	1.9	0.2	-1.6	1.0	-0.9	-0.0	0.3	1.9
Trunk fat mass	0.1	0.5	2.1	-1.2	-0.6	-0.4	-0.4	0.1	-1.5	0.1	-0.6	0.5	-0.5	-0.8	0.1
Waist circumference	0.3	1.0	2.9	-1.7	-1.7	-0.3	-0.1	0.1	-1.5	-0.2	-0.9	0.0	-1.3	-1.0	0.3
Number of incorrect matches in round	1.7	2.8	5.8	-1.3	-2.4	-2.0	-2.1	-0.0	-1.8	0.2	-2.1	2.2	-0.9	-1.9	-0.6
Past tobacco smoking	1.4	2.5	5.1	0.1	-1.2	-2.0	-2.3	-1.9	-1.3	2.0	-1.5	1.4	-1.0	-1.1	-2.1
Alcohol usually taken with meals	0.9	1.5	3.9	1.0	0.8	1.7	1.4	0.8	0.7	-0.4	1.4	-2.0	1.0	1.8	0.6
Nervous feelings	6.6	12.3	21.7	-1.7	-1.2	-4.3	-4.7	-3.6	-3.5	3.5	-4.2	3.8	-2.3	-3.3	-4.1
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.8	-1.5	-1.6	-0.9	-0.8	1.3	-0.4	-1.0	-1.0	2.0	-0.6	-1.4	0.5
Hearing difficulty/problems with background noise	2.5	4.0	7.9	-1.5	-1.9	-2.2	-2.5	-1.5	-2.1	1.4	-2.8	2.0	-1.7	-2.3	-1.6
Hair/balding pattern: Pattern 2	0.6	0.8	3.4	-0.6	-0.6	1.0	0.5	1.6	0.6	-0.7	0.3	-0.6	-0.1	0.1	1.8
Had menopause	0.9	1.1	4.2	-2.0	-0.7	-0.3	0.0	1.5	-0.9	-1.4	-0.6	0.7	-0.6	-0.9	1.1
Had other major operations	0.1	0.1	0.9	0.2	-1.0	0.1	-0.0	-0.4	-0.1	0.2	0.0	-0.3	-0.1	0.0	0.3
Forced vital capacity (FVC)	1.6	6.1	12.0	3.4	2.2	2.6	1.8	-1.3	2.7	1.1	2.9	-3.2	2.2	3.5	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.3	0.4	0.5	0.7	0.8	0.7	1.1	-0.9	0.9	-0.2	1.0	0.8	0.8
Ever unenthusiastic/disinterested for a whole week	3.0	3.7	6.5	-1.5	-2.0	-2.5	-2.1	-1.2	-2.3	1.4	-2.0	2.0	-1.9	-1.9	-1.8
Qualifications: None of the above	0.3	0.7	2.2	-0.4	-1.5	-1.1	-0.9	-0.6	-0.5	0.6	-0.6	1.0	-0.3	-0.7	-0.6
Financial difficulties in last 2 years	1.1	1.4	3.6	0.8	1.0	1.3	1.4	0.8	1.5	-1.1	1.3	-0.5	1.9	0.8	1.2
Mouth/teeth dental problems	0.2	0.3	1.0	-0.6	0.6	-1.0	-0.3	-0.2	-0.1	0.3	-0.4	0.5	-0.9	-0.7	0.0
Heart attack	2.5	3.2	7.0	-1.5	-1.3	-2.6	-1.8	-0.2	-2.2	0.1	-2.1	2.5	-1.8	-2.2	-1.0
Allergy	2.2	5.0	10.1	1.6	2.3	2.8	2.4	1.3	3.2	-1.7	2.5	-1.9	2.5	2.2	1.8
Pain all over the body in last month	0.6	0.6	1.4	1.0	1.2	0.2	-0.6	-1.0	0.8	1.0	0.1	0.0	1.0	0.4	-0.7
Diabetes (self-reported)	0.1	0.1	0.5	-0.3	0.0	-0.2	0.0	-0.5	-0.7	-0.0	-0.2	0.3	0.2	-0.3	-0.7
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.2	-1.0	-1.8	-1.4	-0.9	0.0	-1.4	0.1	-1.2	1.1	-1.4	-1.1	-0.6
Medication: Ramipril	0.1	0.1	0.5	-0.4	-0.5	-0.1	0.4	0.1	-0.1	-0.7	0.1	0.4	0.3	-0.3	0.1
Medication: Simvastatin	0.4	0.6	1.7	-1.1	-1.2	-0.7	-0.2	-0.2	-1.3	-0.1	-0.8	0.4	-1.0	-0.8	-0.3
Fluid intelligence score	0.4	0.8	2.0	-0.1	1.4	0.9	1.2	0.7	0.4	-0.9	1.0	-0.9	0.3	0.7	1.0
Illnesses of siblings	0.7	1.0	2.3	-0.8	-0.9	-1.2	-1.4	-0.5	-0.4	0.9	-1.2	0.8	-1.5	-1.0	-0.9
Neuroticism score	2.5	5.2	8.7	-2.1	-1.9	-2.9	-2.4	-0.9	-2.9	0.9	-3.0	2.7	-2.0	-2.7	-1.6
Weight	0.1	0.6	1.5	-1.2	-0.7	0.6	1.0	1.2	-0.6	-1.0	0.3	-0.4	-0.2	-0.2	1.2
Impedance of arm (right)	1.1	5.3	14.8	3.4	2.2	-0.1	-1.0	-3.9	0.6	3.3	0.4	-1.5	0.8	1.9	-3.7
Arm fat percentage (right)	0.7	2.8	6.2	-1.8	-1.9	-1.8	-1.6	-0.5	-2.5	0.8	-1.8	1.9	-1.2	-2.1	-0.7
Trunk fat-free mass	0.7	4.0	8.4	-0.6	0.3	2.4	2.9	2.8	1.2	-2.6	2.0	-1.7	0.8	1.2	2.8
Hip circumference	0.2	0.6	1.5	-0.5	-0.1	1.0	1.1	1.1	-0.1	-1.0	0.8	-0.6	0.8	0.3	1.2
Time employed in main current job	0.7	0.8	2.7	1.0	-0.6	0.0	-0.2	-1.6	-0.0	1.3	0.3	-1.0	-0.4	0.7	-1.4
Alcohol intake versus 10 years previously	0.9	1.4	4.0	1.9	1.1	0.8	0.5	-1.1	1.1	0.7	1.3	-0.7	2.0	1.3	-0.8
Father’s age at death	0.6	0.8	2.5	1.4	1.6	0.3	-0.4	-0.6	0.6	0.8	0.4	0.1	1.5	0.7	-0.6
Worrier / anxious feelings	2.5	4.7	9.2	-1.6	-0.9	-2.9	-2.5	-1.5	-2.5	1.1	-3.0	2.6	-1.8	-2.3	-2.2
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.5	9.9	-1.5	-0.8	-3.1	-2.7	-1.0	-1.9	1.3	-2.6	2.9	-1.6	-2.6	-1.8
Falls in the last year	2.0	2.7	7.3	-0.5	-0.3	1.4	2.0	2.7	1.3	-2.6	1.4	-1.0	0.8	1.0	2.5
Hair/balding pattern: Pattern 3	3.5	5.2	8.3	-1.8	-2.5	-2.9	-2.2	-1.3	-2.9	0.9	-2.8	2.7	-1.9	-2.5	-2.1
Number of live births	0.8	1.1	4.5	-1.2	-2.1	-0.5	-0.5	-0.1	-1.3	0.1	-1.4	0.2	-1.7	-0.9	-0.1
Forced expiratory volume in 1-second (FEV1)	1.2	4.2	8.2	2.7	2.2	2.1	1.3	-1.3	2.0	1.3	2.2	-2.9	1.4	2.8	-0.9
Pulse rate	0.7	1.1	3.0	0.3	-0.8	1.3	1.3	1.0	1.3	-0.8	0.8	-1.4	0.5	0.6	1.7
Happiness	0.5	0.6	2.0	-0.3	-0.3	-1.0	-0.7	-1.0	-0.8	0.7	-0.8	0.3	-0.7	-0.2	-1.4
Noisy workplace	3.3	4.1	8.4	-2.7	-2.9	-1.7	-2.0	0.1	-2.1	0.7	-2.6	1.6	-2.6	-2.5	-0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	5.5	0.5	2.4	0.4	0.5	0.3	0.0	-0.3	0.3	-0.8	0.1	0.7	0.3
Serious illness, injury or assault of a close relative in last 2 years	2.6	3.0	5.7	-1.1	-0.3	-2.4	-1.9	-2.0	-1.9	1.3	-1.8	2.0	-1.2	-1.8	-1.9
Mouth/teeth dental problems: Dentures	0.7	1.1	3.7	-1.2	-1.5	0.4	0.4	1.9	-0.2	-1.6	-0.1	0.8	-0.0	-0.5	1.5
Asthma	1.1	2.2	4.3	-1.6	-2.1	-1.6	-1.2	-0.0	-2.0	0.4	-1.8	1.4	-1.6	-1.8	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.8	1.1	1.1	0.2	0.0	-0.4	1.0	0.5	0.9	0.1	1.4	0.7	-0.8
Medication: Cholesterol lowering	0.7	1.1	2.7	-0.3	-0.7	-1.7	-1.1	-0.8	-1.3	0.7	-0.9	1.6	-0.1	-0.9	-1.5
Depression (self-reported)	3.2	3.8	7.2	-1.6	-1.1	-2.4	-2.7	-1.1	-1.9	1.4	-2.6	1.8	-2.3	-1.9	-1.7
Medication: Lansoprazole	0.2	0.2	0.9	-0.2	-0.8	0.2	-0.1	1.0	0.2	-0.5	-0.0	-0.1	-0.1	0.0	0.7
Prospective memory result	2.3	2.9	5.5	-2.2	-2.0	-1.7	-1.5	0.8	-1.5	-0.1	-2.0	2.2	-1.6	-2.3	0.2
Lung cancer (father)	1.1	1.3	3.8	-1.8	-1.9	-0.6	-0.2	0.5	-1.0	-0.8	-1.1	0.3	-2.0	-0.9	0.5
Illnesses of mother	1.3	1.6	4.5	-0.4	0.6	1.5	1.8	2.1	1.1	-1.6	1.2	-0.8	0.1	0.4	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	9.6	2.4	1.9	2.3	1.9	-0.5	2.1	0.4	2.3	-3.1	1.0	2.8	-0.1
Pulse wave Arterial Stiffness index	0.6	0.7	3.6	0.2	-1.9	0.8	0.4	0.8	1.0	-0.3	0.8	-0.6	0.4	0.5	0.9
Impedance of arm (left)	1.3	5.8	16.5	3.6	1.8	0.1	-1.1	-4.1	0.5	3.6	0.4	-1.9	0.8	2.1	-3.7
Arm fat mass (right)	0.4	1.5	3.6	-1.9	-1.6	-0.9	-0.6	0.5	-1.9	-0.3	-1.0	1.3	-1.0	-1.6	0.3
Trunk predicted mass	0.8	4.4	9.1	-0.6	0.3	2.5	3.0	3.0	1.3	-2.8	2.1	-1.8	0.8	1.3	2.9
Standing height	1.0	10.1	23.0	3.2	3.1	4.0	3.5	0.1	3.1	-0.5	3.8	-4.8	2.4	4.5	0.5
Length of working week for main job	1.8	2.0	4.2	0.4	-2.1	1.7	1.6	0.8	1.7	-0.9	1.3	-2.0	-0.0	1.1	1.5
Exposure to tobacco smoke at home	5.9	6.6	10.9	-1.6	-2.2	-3.3	-3.2	-2.1	-2.5	2.3	-3.0	2.6	-2.4	-2.8	-2.3
Breastfed as a baby	1.4	1.7	6.2	0.8	2.0	0.9	1.3	0.6	0.4	-1.3	1.8	0.4	2.5	1.2	0.1
Tense / ‘highly strung’	4.7	7.8	12.4	-3.5	-2.1	-3.3	-2.6	-0.0	-3.5	0.6	-3.4	3.4	-3.2	-3.5	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.3	0.3	1.5	-1.7	-1.7	-0.9	-0.8	1.3	-0.9	1.5	0.0	-0.8	-1.8
Hair/balding pattern: Pattern 4	0.2	0.6	2.7	0.1	1.6	-0.7	-0.7	-0.8	-0.9	0.7	-0.6	0.4	-0.2	-0.4	-0.6
Birth weight of first child	0.5	0.9	3.4	0.0	-0.7	-0.6	-1.8	-0.8	-0.7	1.1	-1.3	1.0	-0.1	-0.9	-0.7
Peak expiratory flow (PEF)	0.4	0.8	2.9	0.5	0.8	1.2	1.1	0.3	0.7	-0.0	1.0	-1.7	-0.1	1.3	0.5
Pulse wave reflection index	1.3	1.6	3.0	1.1	-0.4	1.5	1.3	0.8	1.7	-0.9	1.7	-1.2	1.4	1.4	1.2
Ever highly irritable/argumentative for 2 days	0.7	0.9	3.1	-1.8	-1.5	-0.4	-0.1	0.7	-1.0	-0.4	-0.7	0.4	-1.4	-0.8	-0.1
Loud music exposure frequency	1.1	1.2	3.1	-1.4	-1.8	-1.2	-0.7	0.7	-0.9	-0.1	-0.9	1.4	-1.0	-1.3	-0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.5	0.1	1.2	0.7	0.5	0.6	0.6	-0.8	0.0	-0.3	0.3	0.1	1.0
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.7	-0.2	-1.6	-0.6	-1.1	-1.1	-1.3	1.3	-1.1	0.1	-1.0	-0.5	-1.4
Blood clot in the leg (DVT)	1.9	2.4	6.0	-1.3	-0.9	-1.8	-1.9	-0.9	-1.6	1.1	-2.2	1.0	-2.5	-1.6	-0.9
Medication: Paracetamol	0.2	0.3	1.0	-0.1	-0.2	-0.3	-1.0	-0.1	-0.7	0.3	-0.6	0.9	0.1	-0.6	-0.2
Headache pain in last month	0.6	1.1	2.3	-1.3	-0.8	-1.2	-1.0	0.4	-0.9	-0.1	-1.3	1.5	-0.9	-1.3	0.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	4.8	1.0	1.0	1.9	1.4	0.2	1.6	-0.1	1.4	-2.2	0.6	1.6	0.8
Glaucoma (self-reported)	0.5	0.6	4.0	0.5	2.0	0.3	-0.2	0.1	0.4	-0.1	0.4	0.4	1.2	0.6	-0.5
Gout (self-reported)	1.5	2.0	4.8	-0.1	0.0	-1.9	-1.4	-1.8	-1.7	1.3	-1.4	1.4	-0.7	-1.2	-2.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	2.1	1.1	0.7	0.1	-0.6	-1.5	0.0	1.0	-0.1	-0.1	0.9	0.5	-1.3
Medication: Amlodipine	1.2	1.7	6.0	-1.5	0.6	-1.4	-1.2	1.0	-1.2	-0.8	-1.6	2.4	-0.6	-1.8	-0.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	3.5	-1.5	-1.9	-0.4	0.2	0.9	-0.9	-0.6	-0.3	0.6	-0.6	-0.9	0.5
Birth weight	0.3	0.8	1.8	0.6	1.3	1.2	0.6	0.2	0.9	-0.4	0.8	-0.9	1.0	1.2	0.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	4.0	-1.5	-0.8	-1.3	-0.9	-0.2	-2.0	0.3	-1.4	0.8	-1.6	-1.0	-1.0
High blood pressure (siblings)	1.2	1.7	4.4	1.1	1.9	1.4	1.2	0.7	1.0	-0.9	1.5	-0.7	2.1	1.3	1.1
Forced vital capacity (FVC), Best measure	1.3	4.6	9.9	2.8	1.6	2.4	2.1	-0.8	2.4	0.6	2.6	-3.1	1.5	3.1	-0.5
Body fat percentage	0.5	1.8	4.6	-1.5	-1.5	-1.3	-1.4	-0.5	-2.1	0.7	-1.4	1.4	-0.9	-1.7	-0.6
Leg fat percentage (right)	0.6	2.1	4.8	-2.2	-1.8	-1.2	-1.0	0.5	-1.8	-0.2	-1.3	2.1	-0.5	-2.1	0.3
Arm fat-free mass (right)	0.7	3.8	10.3	-1.2	-0.2	2.0	2.6	3.2	0.8	-2.9	1.6	-1.4	0.2	0.7	3.2
Exposure to tobacco smoke outside home	1.1	1.5	4.4	2.1	1.2	-0.2	-0.1	-1.9	0.9	1.4	0.7	-0.5	1.3	1.1	-1.7
Comparative body size at age 10	0.6	1.8	4.8	2.2	1.9	0.9	-0.2	-1.4	1.2	1.6	1.0	-0.9	1.7	1.1	-0.6
Number of full brothers	0.8	1.0	3.3	1.3	0.4	-0.4	-1.1	-1.6	-0.2	1.8	-0.4	-0.2	0.4	0.2	-1.3
Worry too long after embarrassment	2.4	4.0	9.2	-2.7	-1.4	-2.4	-1.5	-0.3	-3.0	0.2	-2.3	2.5	-1.9	-2.5	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.8	0.7	0.3	0.5	0.4	0.4	1.3	-0.2	1.0	-0.2	0.9	0.8	0.3
Wheeze or whistling in the chest in last year	3.1	5.5	13.1	-2.0	-3.6	-2.9	-2.3	-0.7	-2.3	1.2	-2.7	2.6	-2.1	-2.7	-1.4
Number of children fathered	2.0	2.3	5.9	-0.0	0.5	1.4	1.6	2.3	1.8	-2.4	1.1	-0.5	0.9	0.6	2.3
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	6.3	-2.3	-0.1	0.0	0.3	2.5	-1.2	-2.5	-0.9	0.9	-0.8	-0.8	1.5
Age at first live birth	1.1	2.0	7.9	1.1	2.8	1.6	1.6	0.4	0.5	-0.2	1.6	-1.4	1.4	1.6	-0.0
Pulse wave peak to peak time	0.6	0.7	4.3	0.1	2.1	-0.6	-0.3	-0.9	-0.7	0.4	-0.6	0.4	-0.3	-0.3	-1.1
Health satisfaction	0.3	0.4	0.8	-0.9	0.3	-0.5	-0.8	0.3	-0.6	0.1	-0.7	0.8	-0.4	-0.8	-0.3
Shortness of breath walking on level ground	2.1	2.5	4.4	-1.6	-2.1	-1.5	-1.7	-0.3	-2.1	0.5	-2.0	1.7	-1.6	-1.9	-0.8
Qualifications: College or University degree	0.2	0.8	2.0	-0.1	1.4	1.1	1.0	0.9	0.1	-0.6	0.8	-1.1	-0.2	0.6	1.3
Eye problems/disorders: None of the above	0.6	0.7	1.9	0.3	0.4	-1.2	-1.0	-1.2	-0.5	1.4	-0.4	0.4	-0.4	-0.2	-1.3
Mouth/teeth dental problems: Loose teeth	2.4	2.8	5.2	1.5	1.1	2.3	1.9	0.8	1.9	-1.7	1.8	-1.8	2.0	2.0	0.9
Emphysema/chronic bronchitis	0.8	0.8	2.0	0.1	0.0	0.5	1.4	1.3	0.8	-1.4	1.1	-0.0	0.8	0.2	1.3
Medication for pain relief, constipation, heartburn	0.6	1.0	2.4	1.1	1.0	1.1	1.0	0.1	1.4	-0.2	1.1	-1.5	0.5	1.2	0.8
Neck or shoulder pain in last month	0.9	1.2	2.9	-1.4	-1.7	-1.1	-1.0	0.6	-0.5	-0.5	-1.2	1.5	-0.9	-1.4	0.5
Medication: Blood pressure	0.8	1.4	5.5	-0.6	-1.3	-1.7	-1.2	0.1	-1.3	-0.2	-1.0	2.3	0.2	-1.4	-0.4
Angina (self-reported)	0.2	0.2	0.7	-0.1	-0.7	-0.8	-0.4	-0.4	-0.3	0.4	-0.2	0.7	-0.1	-0.6	-0.2
Migraine (self-reported)	2.5	3.0	9.5	0.1	-0.5	-1.7	-1.9	-2.5	-1.8	2.5	-1.5	0.8	-1.4	-0.7	-3.1
Medication: Ibuprofen	0.7	0.8	2.2	1.3	0.7	0.7	0.4	-0.2	1.5	0.3	1.1	-0.5	1.1	1.2	-0.7
Medication: Allopurinol	1.1	1.4	2.7	-0.6	0.1	-1.6	-1.2	-1.2	-1.4	0.4	-1.5	1.6	-0.8	-1.5	-1.2
Medication: Omeprazole	0.1	0.1	0.2	-0.1	-0.1	-0.4	-0.4	-0.5	-0.5	0.2	-0.4	0.3	-0.0	-0.3	-0.4
Medication: Seretide 50 evohaler	0.4	0.5	1.8	-1.4	-0.8	-0.5	0.9	0.4	-0.6	-0.8	0.1	0.4	-0.6	-0.6	0.4
Mean time to correctly identify matches	1.4	2.7	7.6	-1.6	0.7	-2.2	-1.5	-0.3	-2.4	-0.0	-1.8	2.8	-0.5	-2.1	-0.9
Heart disease (mother)	0.2	0.3	1.1	0.7	0.3	-0.3	-0.4	-1.0	-0.4	0.8	0.1	-0.0	0.5	0.3	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	4.2	-1.0	0.3	-1.4	-1.4	-0.3	-1.2	0.5	-1.2	2.0	-0.4	-1.4	-0.7
Whole body fat mass	0.2	0.8	2.6	-1.5	-1.2	-0.6	-0.4	0.3	-1.6	-0.1	-0.7	0.8	-0.5	-1.2	0.3
Leg fat mass (right)	0.3	1.1	3.2	-1.8	-1.2	-0.7	-0.2	0.8	-1.3	-0.6	-0.6	1.4	-0.3	-1.4	0.7
Arm predicted mass (right)	0.7	3.8	9.9	-1.2	-0.2	1.9	2.6	3.1	0.9	-2.9	1.6	-1.3	0.3	0.7	3.1
Pulse rate, automated reading	1.0	3.3	10.8	2.4	-0.3	2.0	1.7	-1.6	1.6	1.1	1.6	-3.3	0.9	2.4	-0.4
Alcohol intake frequency.	0.3	0.8	2.2	0.9	0.5	-0.2	-1.1	-1.5	0.3	1.5	-0.3	0.1	0.6	0.3	-1.4
Comparative height size at age 10	1.2	6.6	11.5	2.0	1.8	3.1	3.4	1.2	2.6	-2.1	3.2	-3.1	2.3	3.1	1.7
Number of full sisters	0.4	0.5	1.5	0.8	0.5	0.3	0.5	-0.8	0.2	0.6	0.7	-1.2	0.1	1.1	-0.8
Suffer from ‘nerves’	10.3	16.2	25.6	-3.0	-2.7	-5.0	-4.5	-3.2	-5.1	3.6	-4.8	3.7	-4.1	-4.3	-3.5
Overall health rating	1.4	3.0	6.0	-0.3	-0.4	-2.2	-2.4	-2.0	-1.3	2.0	-1.7	2.1	-0.6	-1.5	-2.4
Chest pain or discomfort	0.2	0.3	3.2	0.1	-1.8	-0.5	-0.2	0.1	0.2	0.0	-0.2	0.1	-0.2	0.3	-0.6
Had major operations	0.9	1.0	2.8	-1.6	-1.4	-1.0	-0.4	0.2	-0.5	-0.1	-0.8	0.6	-1.7	-1.3	0.9
Age at last live birth	0.7	1.1	3.6	0.5	1.9	1.2	1.4	0.5	0.3	-0.4	1.4	-0.7	1.2	1.0	0.2
Family relationship satisfaction	0.4	0.5	1.1	0.6	1.0	0.3	0.8	-1.1	0.3	0.4	0.6	-1.0	0.3	0.7	-0.2
Leg pain on walking	0.6	0.8	2.7	-0.8	-0.1	0.9	0.4	1.6	-0.4	-1.4	-0.0	-0.0	0.1	-0.4	1.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	1.0	-0.2	-1.0	-0.1	0.6	0.2	0.2	-0.6	0.1	-0.1	-0.3	-0.2	0.4
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.2	-1.1	0.1	-0.8	-0.1	0.4	-0.4	-0.4	-0.3	1.1	-0.4	-0.8	-0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.4	-0.4	-0.5	0.1	-0.4	0.3	-0.4	-0.0	-0.6	0.2	-0.6	-0.5	0.1
Medication: Aspirin	0.1	0.2	0.6	-0.4	0.7	-0.4	-0.2	0.4	-0.4	-0.3	-0.1	0.8	0.1	-0.3	-0.4
Supplements: Vitamin C	1.3	1.5	4.8	-0.5	-0.7	1.0	1.0	2.2	1.0	-2.1	0.8	0.2	0.8	0.2	2.0
Knee pain experienced in last month	1.2	1.9	6.4	-1.4	-1.9	0.1	0.4	2.2	0.2	-2.1	-0.2	0.7	-0.3	-1.0	2.5
Hypertension (Self-reported)	0.4	1.0	3.0	-0.6	0.5	-1.1	-0.9	-0.5	-1.7	0.4	-1.0	1.7	0.0	-1.4	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	4.2	-1.9	-1.9	-0.4	-0.5	-0.0	-1.2	0.0	-1.4	-0.0	-2.0	-1.1	0.2
Illnesses of father: Heart disease	1.1	1.5	4.5	1.5	0.9	0.5	-0.4	-2.0	-0.1	2.1	0.1	-1.5	0.2	1.1	-1.6
Illnesses of siblings: Diabetes	0.2	0.3	0.6	0.2	0.5	-0.3	-0.5	-0.4	-0.6	0.6	-0.3	0.7	0.8	-0.3	-0.6
Smoking status: Previous	1.0	1.5	3.0	-0.6	1.4	1.4	1.7	1.7	0.6	-1.7	1.0	-0.9	0.4	0.6	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	5.4	1.6	0.8	1.2	1.0	-1.0	1.5	0.8	1.3	-2.3	0.1	1.6	-0.6
Whole body fat-free mass	0.6	3.3	7.5	-1.0	0.1	2.0	2.5	2.7	0.8	-2.5	1.7	-1.5	0.4	0.9	2.7
Leg fat-free mass (right)	0.2	1.1	2.8	-1.0	-0.0	1.1	1.5	1.7	0.2	-1.5	0.8	-0.9	-0.1	0.3	1.7
Arm fat percentage (left)	0.7	2.8	6.4	-1.8	-2.0	-1.8	-1.7	-0.5	-2.5	0.8	-1.8	1.9	-1.2	-2.1	-0.6
Average weekly red wine intake	1.4	2.0	4.8	0.3	0.2	1.6	2.2	1.7	0.6	-1.6	1.5	-1.8	0.6	1.4	1.7
Handedness (chirality/laterality): Left-handed	1.0	1.3	6.0	1.9	1.2	0.3	0.2	-0.3	1.3	-0.1	1.1	0.6	2.4	0.7	-0.3
Mood swings	1.9	3.4	5.7	-1.4	-1.8	-2.4	-2.2	-0.9	-1.9	0.9	-2.3	2.4	-1.5	-2.2	-1.4
Loneliness, isolation	0.1	0.1	0.9	-0.0	-0.9	0.1	-0.2	-0.2	-0.1	0.1	-0.4	0.1	-0.2	-0.3	0.1
Long-standing illness, disability or infirmity	0.3	0.4	1.2	0.8	0.5	-0.5	-0.5	-0.8	-0.9	0.4	-0.1	0.7	0.8	0.1	-1.1
Ever had bowel cancer screening	1.8	2.1	7.3	0.5	-0.2	-1.5	-1.9	-1.9	-1.5	2.0	-0.9	1.0	0.0	-0.2	-2.7
Diabetes diagnosed by doctor	0.2	0.4	1.5	-0.4	0.3	-0.6	-0.1	-1.0	-0.8	0.2	-0.4	0.5	0.1	-0.4	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	4.1	1.4	0.1	0.0	-0.1	-2.0	-0.5	1.8	0.5	-0.9	0.3	0.6	-1.4
Friendships satisfaction	0.1	0.1	0.4	0.1	0.2	-0.5	-0.3	-0.5	-0.2	0.4	-0.3	0.1	-0.1	0.1	-0.6
Qualifications: nursing, teaching	0.4	0.6	1.5	0.0	-0.0	-0.7	-1.0	-1.0	-0.5	1.1	-0.9	-0.0	-0.9	-0.2	-1.2
Commuting to job workplace: Walk	2.3	2.5	5.5	0.4	0.4	1.9	2.1	1.5	1.4	-2.0	1.4	-1.7	1.1	1.3	2.3
Eye problems/disorders: Cataract	1.0	1.2	4.4	-0.7	-0.3	1.0	1.5	1.6	0.5	-2.1	0.5	-0.4	0.1	0.3	1.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	3.7	-0.1	-1.9	-0.4	-0.7	-0.4	-0.4	0.9	-0.7	0.0	-0.8	-0.3	-0.4
Medication for cholesterol	0.8	1.3	2.7	1.6	0.8	1.3	0.7	0.4	1.6	-0.4	1.2	-0.9	1.5	1.6	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.3	-1.1	-1.0	-0.3	0.2	1.1	-0.0	-1.0	-0.3	1.0	0.1	-1.1	1.5
Back pain experienced in last month	1.2	1.7	3.2	0.7	0.2	1.2	1.5	1.6	1.4	-1.7	1.5	-0.3	1.8	1.0	1.6
Mineral and other dietary supplements	1.2	1.6	5.0	0.5	-0.4	-1.0	-1.5	-2.2	-0.6	2.0	-1.0	0.5	-0.6	-0.5	-2.2
Breast cancer (self-reported)	0.2	0.3	1.2	-0.5	-1.1	-0.1	-0.7	0.1	-0.5	-0.1	-0.7	0.5	-0.3	-0.7	0.4
Asthma (self-reported)	1.4	2.8	5.6	-1.9	-2.2	-1.9	-1.3	-0.2	-2.4	0.5	-2.0	1.6	-1.8	-2.0	-0.6
Osteoporosis (self-reported)	1.4	1.8	3.7	-1.0	-1.1	-1.8	-1.7	-0.4	-1.6	0.7	-1.3	1.9	-0.9	-1.5	-1.0
Osteoarthritis (self-reported)	0.3	0.4	1.5	0.1	0.4	0.4	-0.0	1.2	0.8	-0.9	0.5	0.4	0.7	0.1	1.0
Medication: Aspirin	0.2	0.2	0.9	-0.4	0.4	-0.5	-0.2	0.3	-0.6	-0.3	-0.2	0.9	0.1	-0.5	-0.5
Medication: Gliclazide	0.9	1.0	2.0	-0.9	-1.4	-1.0	-0.4	-0.9	-1.2	0.9	-0.8	0.3	-1.3	-0.7	-1.3
Illnesses of father: None of the above (group 1)	0.3	0.4	0.9	-0.2	-0.7	-0.1	0.4	0.9	0.9	-0.8	0.5	0.6	0.3	-0.0	0.7
Smoking status: Current	2.5	3.9	10.1	1.4	-0.2	2.1	2.5	1.3	3.2	-1.7	2.4	-1.7	1.9	1.9	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.8	0.9	0.4	0.2	-0.0	0.1	0.4	0.2	0.4	-0.3	0.6	0.6	0.0
Whole body water mass	0.6	3.3	7.7	-1.0	0.1	2.0	2.5	2.8	0.8	-2.5	1.6	-1.5	0.4	0.9	2.8
Leg predicted mass (right)	0.2	1.2	3.0	-1.0	-0.0	1.2	1.6	1.7	0.2	-1.5	0.9	-0.9	-0.1	0.3	1.7
Arm fat mass (left)	0.3	1.4	3.5	-1.9	-1.7	-0.8	-0.5	0.6	-1.9	-0.3	-0.9	1.1	-0.9	-1.5	0.5
Number of self-reported non-cancer illnesses	2.8	4.8	9.7	-1.6	-0.9	-3.0	-2.3	-1.4	-3.1	1.4	-2.5	2.5	-1.9	-2.4	-2.0
Average weekly champagne plus white wine intake	0.1	0.1	0.4	0.1	-0.3	-0.1	0.4	-0.2	-0.6	-0.0	0.1	0.0	-0.2	0.2	-0.6
Miserableness	2.5	4.3	7.6	-1.4	-1.2	-2.4	-2.8	-1.8	-2.6	1.6	-2.7	2.1	-1.6	-2.1	-1.8
Guilty feelings	0.4	0.5	4.6	-0.2	-2.1	-0.2	-0.0	0.5	-0.0	-0.6	-0.2	0.2	-0.1	-0.2	1.0
Wears glasses or contact lenses	1.6	1.9	4.0	-1.7	-2.0	-1.3	-1.3	0.7	-1.7	-0.1	-1.6	1.2	-1.5	-1.5	0.5
Ever taken oral contraceptive pill	1.9	2.2	3.7	1.6	1.3	1.6	1.6	0.9	1.6	-0.8	1.9	-1.6	1.5	1.8	0.9
Hearing aid user	2.0	2.2	5.8	-1.0	0.2	-1.7	-2.4	-1.5	-0.8	1.5	-2.2	1.3	-1.3	-1.3	-1.3
Mother’s age at death	0.8	1.0	2.6	-0.9	0.0	-1.0	-1.4	-0.4	-1.6	1.0	-1.1	0.9	-0.7	-0.7	-1.2
Financial situation satisfaction	0.6	0.7	1.6	-0.3	-1.0	-1.2	-1.3	-0.4	-0.5	0.8	-1.0	0.8	-0.6	-0.7	-0.8
Tinnitus: Yes, now most or all of the time	2.5	2.9	6.8	-1.0	0.2	-1.8	-1.8	-1.7	-2.6	1.9	-1.8	1.0	-1.6	-1.1	-2.4
Commuting to job workplace: Public transport	2.1	2.5	4.8	1.9	0.9	2.2	1.3	0.4	2.0	-0.5	1.9	-1.7	2.0	2.0	0.5
Eye problems/disorders: Glaucoma	0.3	0.3	0.9	0.1	1.0	-0.3	-0.8	-0.4	-0.2	0.1	-0.5	0.9	0.5	-0.2	-0.7
Medication: Blood pressure	0.2	0.4	1.0	-0.7	0.6	-0.5	-0.3	-0.7	-1.0	0.8	-0.3	0.4	-0.5	-0.8	-0.2
Pain type(s) experienced in last month: Hip pain	3.2	4.0	13.3	-1.9	-2.2	1.1	1.9	3.7	0.1	-3.3	0.5	-0.1	-0.7	-0.4	3.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.0	-0.7	-0.2	0.4	1.0	1.7	-0.0	-1.6	0.3	0.1	0.1	-0.0	1.6
High cholesterol (Self-reported)	1.2	2.1	7.6	0.9	0.5	-1.4	-1.5	-2.5	-0.7	2.3	-0.7	0.6	-0.0	-0.2	-2.8
Medication: Bendroflumethiazide	0.6	1.0	2.6	-0.8	-1.1	-1.1	-0.7	-0.4	-1.6	0.3	-0.9	1.6	-0.3	-1.5	-0.0
Medication: Paracetamol	0.3	0.4	1.4	0.3	0.3	-0.5	-1.2	-0.7	-0.3	0.8	-0.6	0.9	0.3	-0.4	-0.8
Medication: Lisinopril	0.8	1.1	2.6	-0.4	-0.3	-1.3	-1.6	-0.6	-1.0	0.9	-1.1	1.6	-0.2	-1.1	-1.3
Medication: Atorvastatin	0.4	0.5	1.8	0.8	0.5	-0.5	-0.0	-0.8	0.0	0.6	0.8	0.5	1.3	0.3	-1.2
Illnesses of father: High blood pressure	0.8	1.0	8.4	1.0	2.9	-0.3	-0.4	-0.6	-0.5	0.7	0.2	0.7	1.0	-0.2	-0.6
Alcohol drinker status: Never	0.1	0.1	0.3	0.4	0.6	0.3	-0.2	0.0	0.4	-0.1	-0.1	-0.1	0.4	0.1	-0.1
Ever smoked	0.8	1.4	2.5	0.8	1.1	1.6	1.4	0.8	1.5	-0.7	1.3	-1.5	0.9	1.2	1.1
Basal metabolic rate	0.4	2.4	5.7	-0.9	-0.0	1.7	2.2	2.4	0.5	-2.1	1.4	-1.3	0.3	0.6	2.4
Leg fat percentage (left)	0.6	2.3	5.0	-2.2	-2.0	-1.2	-1.1	0.5	-1.9	-0.0	-1.5	2.0	-0.8	-2.1	0.3
Arm fat-free mass (left)	0.7	3.5	9.5	-1.1	-0.1	2.0	2.5	3.1	0.8	-2.8	1.5	-1.2	0.4	0.7	2.9
Number of operations (self-reported)	0.3	0.5	2.1	0.7	-1.4	0.0	0.2	-0.7	0.2	0.9	0.6	-0.9	-0.1	0.6	0.2
Average weekly beer plus cider intake	2.1	3.0	11.0	1.9	0.9	-1.4	-1.5	-3.3	-0.2	2.6	-0.1	1.3	1.1	-0.5	-2.7
Irritability	0.6	1.0	2.7	-0.6	-0.7	-1.3	-1.3	-0.1	-1.1	0.3	-1.1	1.6	-0.3	-1.3	-0.5
Risk taking	2.0	3.0	7.1	-0.1	-1.6	1.5	2.1	2.6	1.4	-2.5	1.4	-1.2	0.1	0.8	2.7
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.0	1.2	1.2	1.1	1.3	0.8	1.1	-0.5	1.6	-1.4	1.5	1.7	0.3
Fractured/broken bones in last 5 years	0.1	0.2	0.4	0.6	-0.1	-0.2	0.0	-0.4	-0.6	0.6	0.3	-0.2	-0.1	0.4	-0.6
Age started oral contraceptive pill	0.5	0.6	1.7	-1.2	0.2	-0.8	-0.6	0.6	-1.3	-0.1	-0.6	1.2	-0.5	-0.8	-0.3
Diastolic blood pressure, automated reading	0.2	0.6	2.0	0.9	0.7	1.1	0.6	0.3	0.4	-0.1	0.7	-0.6	1.4	0.7	0.5
Ever depressed for a whole week	1.8	2.2	6.0	-1.9	-2.4	-1.3	-0.8	1.0	-1.6	-0.7	-1.4	1.4	-1.6	-1.7	0.7
Unable to work because of sickness or disability	2.2	2.8	7.1	1.5	-0.0	2.0	1.6	1.3	2.7	-1.5	2.0	-1.3	1.8	1.9	1.3
Commuting to job workplace: Cycle	0.4	0.5	1.7	-1.0	-1.3	-0.2	-0.6	0.6	-0.6	-0.2	-0.7	0.4	-1.0	-0.8	0.6
Myopia	0.1	0.2	0.7	-0.3	0.8	-0.2	-0.1	-0.2	-0.6	-0.3	-0.5	0.3	-0.1	-0.4	0.1
Vascular/heart problems diagnosed by doctor	1.1	2.9	7.7	1.4	0.6	2.2	1.7	0.8	2.4	-0.6	1.8	-2.8	0.7	2.3	1.2
Cholesterol lowering medication	0.6	0.9	2.0	-0.6	-1.0	-0.9	-0.8	-1.2	-1.4	1.2	-0.8	0.2	-1.0	-0.7	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.3	-0.7	-1.2	-0.8	-0.9	-0.6	-0.9	0.4	-1.1	0.6	-0.7	-1.0	-0.2
Pain experienced in last month	0.6	1.0	2.0	1.4	1.2	0.5	0.2	-1.2	0.3	1.1	0.5	-1.4	0.2	1.3	-1.4
Supplements: Calcium	0.2	0.3	0.8	0.5	0.9	0.5	0.3	0.1	0.7	-0.2	0.4	-0.5	0.5	0.6	0.1
Basal cell carcinoma (self-reported)	0.5	0.6	1.8	-0.1	0.5	-0.9	-0.7	-1.1	-0.8	0.6	-1.1	0.4	-0.7	-0.3	-1.4
Heart attack/myocardial infarction (self-reported)	2.8	3.6	8.1	-1.5	-1.4	-2.8	-1.8	-0.3	-2.3	0.1	-2.1	2.7	-1.8	-2.3	-1.1
Deep venous thrombosis (DVT) (self-reported)	2.8	3.6	8.5	-1.7	-1.3	-2.2	-2.3	-1.0	-2.0	1.2	-2.6	1.4	-2.9	-2.0	-1.1
Heart disease (siblings)	0.1	0.2	0.8	0.3	0.9	0.4	0.6	0.2	0.1	-0.3	0.4	-0.4	0.4	0.4	-0.0
Alcohol drinker status: Previous	2.5	2.9	4.4	1.2	2.1	2.0	1.6	1.1	1.9	-1.1	2.0	-1.7	1.8	2.0	1.3
Pack years of smoking	0.4	0.6	3.1	-0.3	-1.8	-0.2	0.4	0.9	-0.6	-1.0	0.1	0.8	0.0	-0.7	0.7
Impedance of whole body	1.0	5.2	14.1	3.8	2.2	0.5	-0.6	-3.5	1.2	3.0	0.8	-1.9	1.3	2.3	-3.1
Leg fat mass (left)	0.3	1.1	3.4	-1.8	-1.5	-0.6	-0.3	0.9	-1.3	-0.6	-0.7	1.3	-0.5	-1.5	0.7
Arm predicted mass (left)	0.7	3.7	9.6	-1.2	-0.1	2.0	2.6	3.1	0.8	-2.9	1.6	-1.2	0.5	0.7	3.0