Hub : Genes

BAIAP2L1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0920 0.0320 7.6e-04 0.073 NA 0.064 NA 0.056 1.3e-06 NA 5.8e-06 NA 2.1e-05
2 GTEx Adipose Visceral Omentum 0.3070 0.0780 1.6e-05 0.001 NA 0.001 NA 0.020 2.9e-01 NA 2.8e-01 NA 3.1e-02
3 GTEx Skin Not Sun Exposed Suprapubic 0.0960 0.0350 2.1e-04 0.125 NA 0.124 NA 0.125 2.3e-07 NA 2.7e-07 NA 2.3e-07
4 GTEx Skin Sun Exposed Lower leg 0.1090 0.0350 7.7e-07 0.065 NA 0.084 NA 0.101 4.5e-06 NA 1.9e-07 NA 1.0e-08
5 GTEx Testis 0.3250 0.0740 1.4e-05 0.265 NA 0.178 NA 0.256 3.8e-12 NA 2.5e-08 NA 9.6e-12
6 GTEx Thyroid 0.0890 0.0280 2.0e-06 0.055 NA 0.071 NA 0.071 4.6e-05 NA 3.9e-06 NA 4.1e-06
7 NTR Blood 0.0223 0.0084 1.0e-04 0.015 0.011 0.010 0.011 0.012 1.2e-05 1.5e-04 2.5e-04 0.00011 7.0e-05
8 ROSMAP Brain Pre-frontal Cortex 0.0425 0.0157 4.3e-06 0.039 0.016 0.036 0.015 0.036 7.5e-06 3.5e-03 1.8e-05 0.00380 1.9e-05
9 TCGA Breast Invasive Carcinoma 0.0413 0.0234 7.9e-08 0.031 0.030 0.024 NA 0.025 3.9e-07 7.6e-07 9.5e-06 NA 4.9e-06
10 TCGA Kidney Renal Clear Cell Carcinoma 0.0795 0.0455 5.8e-06 0.057 0.063 0.059 NA 0.057 5.0e-07 1.2e-07 3.1e-07 NA 4.7e-07
11 TCGA Pancreatic Adenocarcinoma 0.1070 0.0840 2.1e-03 0.037 0.032 0.028 NA 0.022 1.1e-02 1.7e-02 2.4e-02 NA 3.9e-02
12 TCGA Thyroid Carcinoma 0.1140 0.0620 9.7e-06 0.048 0.059 0.049 NA 0.050 1.9e-05 1.9e-06 1.6e-05 NA 1.2e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 2.1 3.3 6.2 1.4 0.9 2.4 2.2 1.1 1.9 -1.3 2.5 -1.3 2.4 1.8 1.5
Bipolar Disorder or Schizophrenia 0.8 2.0 6.2 -0.9 -0.6 1.8 1.8 2.3 0.4 -2.0 0.8 -0.7 0.3 0.1 2.5
Depressed Affect (Nagel 2018) 1.7 3.6 5.8 -1.4 -1.6 -2.3 -2.2 -1.3 -2.4 1.2 -2.4 2.0 -1.6 -2.1 -1.7
Depression (Nagel 2018) 0.6 0.9 3.6 -0.8 -1.9 -1.1 -1.3 -0.3 -0.6 0.4 -1.1 0.8 -0.7 -0.7 -0.7
Intelligence (Savage-Jansen 2018) 0.2 0.8 2.1 -0.6 0.6 0.5 1.2 1.4 0.2 -1.4 1.0 -0.5 -0.1 0.3 1.2
Neuroticism (Nagel 2018) 5.8 13.6 22.5 -3.0 -2.5 -4.7 -4.3 -2.3 -4.6 2.4 -4.5 4.2 -3.1 -4.2 -3.1
Schizophrenia (2018) 1.0 2.0 5.0 -2.2 -1.6 0.4 0.5 2.1 -1.1 -1.5 -1.0 0.1 -1.6 -1.3 2.0
Schizophrenia vs Biploar Disorder 0.2 0.3 0.9 -0.6 0.7 0.3 0.5 0.9 0.1 -0.8 -0.1 -0.2 -0.1 -0.3 1.0
Worry (Nagel 2018) 6.5 13.7 22.9 -2.5 -1.7 -4.8 -4.4 -2.9 -4.4 3.4 -4.3 4.0 -3.0 -3.9 -3.8
Alzheimer’s Disease (in mother) 0.1 0.1 0.4 0.4 -0.3 -0.3 -0.5 -0.1 0.1 -0.0 0.1 0.3 0.7 0.5 -0.5
Alzheimer’s Disease (in father) 0.5 0.6 1.1 0.4 -0.2 0.7 1.0 0.6 1.0 -1.0 0.9 -0.2 1.0 0.5 0.7
Alzheimer’s Disease (including proxy) 0.2 0.2 1.0 0.8 -0.2 -0.2 -0.3 -0.2 0.5 -0.2 0.3 0.4 1.0 0.4 -0.5
Crohns Disease (2017) 0.1 0.3 1.0 0.5 0.6 0.7 0.6 0.0 0.0 -0.1 0.8 -1.0 0.2 0.5 0.6
Irritable Bowel Disease (IBD) 0.3 0.7 1.4 -0.3 -0.3 -1.0 -1.2 -0.7 -0.9 0.6 -1.0 0.9 -0.9 -1.0 -0.6
Ulcerative Colitis (UC) 1.7 3.1 5.7 -0.8 -1.1 -2.2 -2.4 -1.3 -1.6 1.2 -2.3 2.1 -1.6 -2.0 -1.8
Major Depression (MDD) 0.3 0.4 1.1 -0.5 -0.7 -0.8 -0.6 -0.5 -0.8 0.4 -0.5 0.3 -0.9 -0.2 -1.1
Reaction Time 0.9 1.7 5.8 -0.8 2.1 -1.5 -1.1 -0.3 -1.2 -0.2 -1.3 2.4 0.2 -1.6 -0.7
Verbal and Numeric Reasoning (VNR) 0.6 1.3 4.2 -0.8 0.5 0.7 1.5 2.0 0.2 -2.0 0.9 -0.3 0.1 0.4 1.7
Breast Cancer 3.8 9.2 21.9 4.2 4.7 2.1 1.6 -0.2 3.4 0.5 3.8 -1.8 4.5 3.7 -0.6
Ovarian Cancer 2.4 3.2 6.6 2.0 0.8 2.2 2.0 0.2 1.9 -0.4 2.5 -2.3 1.9 2.6 0.2
Prostate Cancer 18.0 25.3 43.8 2.4 1.4 6.2 6.6 4.9 5.4 -5.0 6.3 -5.2 3.9 4.8 5.7
Age at First Birth 0.1 0.1 0.4 0.4 0.5 0.2 0.4 0.1 -0.3 0.1 0.5 -0.3 0.6 0.4 0.0
Bipolar Disorder (2011) 0.9 0.8 1.7 0.1 0.1 1.2 1.3 0.8 1.0 -1.0 1.2 -1.0 0.4 0.9 1.0
Body Mass Index (BMI) (2010) 0.2 0.2 0.8 -0.5 -0.1 0.3 0.3 0.9 -0.1 -0.8 -0.3 0.1 0.1 -0.2 0.7
Coronary Artery Disease (CAD) 0.3 0.4 0.9 -0.3 0.2 -0.9 -0.8 -0.4 -0.2 0.5 -0.2 1.0 -0.1 -0.5 -1.0
Crohns Disease (2012) 0.3 0.5 1.6 -0.1 -0.1 0.8 0.8 0.8 0.4 -0.7 0.8 -1.0 -0.0 0.4 1.3
Mean Putamen Volume 0.4 0.5 1.6 -0.2 -1.3 0.0 0.2 -0.9 -0.9 0.4 -0.6 -0.8 -1.1 0.1 -0.7
Fasting Glucose 3.2 3.8 6.7 -1.4 -1.7 -2.6 -2.5 -1.6 -1.3 1.3 -2.4 2.1 -1.8 -2.3 -1.7
HbA1C 0.5 0.6 2.1 -0.1 0.3 -1.2 -0.3 -1.1 -0.3 1.4 -0.8 0.3 -0.5 -0.6 -0.7
HDL Cholesterol 0.3 0.5 2.9 0.8 1.7 0.6 -0.1 0.1 0.9 0.2 0.5 -0.4 0.7 0.7 0.1
LDL Cholesterol 3.1 4.9 18.1 1.8 0.8 -1.6 -2.1 -4.3 -0.9 3.7 -1.1 -0.1 -0.0 0.1 -3.7
Lupus 2.0 3.1 6.2 2.3 1.0 2.3 1.5 -0.3 2.1 0.3 2.0 -2.5 1.8 2.2 0.5
Neuroticism (2016) 1.5 2.2 5.2 -0.3 -1.2 -2.1 -1.6 -1.6 -1.5 1.3 -1.3 1.4 -1.2 -1.0 -2.3
Primary Biliary Cirrhosis 0.2 0.3 1.5 -0.3 -1.2 0.2 0.7 0.7 0.3 -0.6 0.2 -0.4 -0.3 -0.0 0.8
Rheumatoid Arthritis 0.3 0.5 1.4 0.1 -1.2 -0.9 -0.9 -0.7 -0.4 0.9 -0.6 0.3 -0.7 -0.5 -0.4
Schizophrenia (2014) 1.0 2.1 7.1 -1.7 -0.5 1.3 1.6 2.4 -0.3 -2.1 0.2 -0.6 -0.3 -0.4 2.7
Triglycerides 0.3 0.5 1.2 -0.0 -1.1 -0.8 -0.7 -1.1 -0.1 1.0 -0.5 0.9 0.0 -0.6 -0.7
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.8 0.0 -0.4 0.4 0.5 -0.6 0.2 0.4 0.4 -0.9 -0.9 0.5 -0.8
Ulcerative Colitis 0.7 1.0 2.8 -1.0 -0.6 -1.3 -0.9 -0.0 -0.9 -0.3 -1.3 1.7 -0.5 -1.4 -0.2
Blood Eosinophil Count 1.0 8.1 14.0 -3.2 -3.7 -3.0 -2.8 -0.9 -3.0 1.2 -3.4 2.7 -3.6 -3.5 -1.1
Blood Platelet Count 0.2 2.2 5.9 -0.3 -1.3 -1.4 -1.2 -2.4 -1.2 2.1 -1.2 0.3 -1.8 -1.0 -1.9
Blood Red Count 0.9 8.7 20.9 4.6 4.3 0.9 -0.2 -3.3 1.4 3.3 2.2 -1.5 3.1 3.1 -3.8
Blood White Count 1.1 8.1 18.4 0.5 -1.6 3.8 4.2 2.2 2.3 -2.5 2.6 -4.3 0.2 2.4 3.9
Heel T-Score 1.3 10.3 36.8 -3.1 0.0 2.3 3.0 5.3 1.1 -5.6 0.7 -0.1 -0.1 -0.7 6.1
BMI 0.4 2.2 5.3 -2.3 -2.1 -0.7 -0.0 1.8 -1.0 -1.7 -0.9 1.6 -0.8 -1.8 1.4
Height 0.3 6.7 15.3 2.8 3.1 3.1 2.4 -0.1 1.7 -0.2 2.9 -3.9 2.3 3.8 0.1
Waist Hip Ratio (WHR) 0.7 3.1 8.8 -0.2 -1.5 -1.1 -1.2 -3.0 -1.4 2.3 -1.7 -0.8 -2.6 -0.5 -2.5
Systolic Blood Pressure 0.6 3.2 6.2 1.4 2.1 2.3 2.5 0.9 1.8 -1.5 2.0 -1.6 2.0 1.6 1.0
Smoking Status 3.2 7.6 13.5 1.6 1.3 3.4 3.6 1.8 3.7 -2.2 3.4 -3.1 2.3 2.8 2.7
Allergy or Eczema 3.3 8.7 14.6 -2.8 -1.8 -3.5 -3.4 -1.1 -3.8 1.6 -3.8 3.2 -3.2 -3.5 -1.9
Cardiovascular Disease 0.6 2.1 4.3 -0.1 -0.1 -1.6 -1.5 -2.1 -1.5 1.8 -1.5 1.3 -0.6 -1.3 -2.1
Hypothyroidism (self reported) 0.5 1.3 3.0 1.7 1.1 0.9 -0.1 -1.4 0.9 0.9 0.5 -1.2 1.3 1.4 -1.0
Respiratory disease 1.5 3.3 10.8 -1.5 -3.3 -2.2 -1.4 -0.7 -2.0 0.6 -2.0 1.7 -1.7 -1.9 -1.1
Type 2 Diabetes (T2D) (2018) 0.7 1.4 4.3 1.3 1.7 -0.4 -0.1 -2.0 -0.2 1.2 0.3 -0.1 1.0 0.6 -2.1
Lung FEV1/FVC ratio 0.3 1.4 3.6 0.6 1.9 1.5 1.1 0.3 0.7 -0.5 0.9 -1.9 0.4 1.1 1.4
Lung FVC 0.5 2.5 6.2 2.5 0.5 0.9 0.6 -1.4 1.0 1.6 1.6 -1.4 1.6 2.2 -2.2
Neuroticism 2.1 5.1 8.8 -2.1 -2.0 -3.0 -2.3 -1.1 -2.9 1.1 -2.7 2.4 -2.2 -2.5 -1.9
Chronotype (morning person) 3.5 8.1 13.0 2.2 3.0 3.6 3.3 1.7 3.1 -1.6 3.4 -3.1 3.0 3.2 2.1
Hair Pigment 0.1 2.2 4.2 -1.1 1.0 -1.8 -2.1 -1.0 -1.4 1.0 -1.9 1.9 -1.1 -1.9 -0.9
Tanning 0.6 6.9 12.8 0.9 -0.5 2.9 3.6 2.7 2.7 -2.8 3.2 -3.0 1.3 2.8 3.1
Hand grip strength (left) 2.1 5.5 8.6 1.6 2.5 2.7 2.7 1.3 2.9 -1.6 2.9 -2.1 2.3 2.3 2.3
Number of treatments/medications taken 1.3 2.3 4.5 -1.3 -1.3 -2.0 -1.8 -0.6 -2.0 0.8 -1.6 2.1 -0.8 -1.7 -1.3
Average weekly spirits intake 1.0 1.2 2.5 0.4 -0.5 1.1 0.9 1.4 1.1 -1.2 1.3 -0.3 1.5 0.8 1.6
Sensitivity / hurt feelings 4.1 7.1 13.4 -2.5 -2.5 -3.1 -2.8 -1.2 -3.3 1.0 -3.7 2.8 -2.8 -3.2 -1.6
Frequency of depressed mood in last 2 weeks 0.8 1.1 2.5 -0.8 -1.0 -1.5 -1.6 -0.3 -0.4 0.4 -1.4 1.5 -0.6 -1.0 -1.0
Hearing difficulty/problems: Yes 0.4 0.5 1.3 -0.7 -0.7 -0.6 -1.0 -0.5 -0.9 0.6 -1.1 0.5 -0.6 -0.9 -0.2
Relative age of first facial hair 0.4 0.9 2.2 0.5 -1.3 -0.6 -0.8 -1.4 -0.8 1.5 -0.5 -0.1 -0.7 -0.0 -1.3
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.6 0.8 1.3 1.1 0.7 0.3 0.4 -0.3 0.7 -1.0 0.6 1.3 -0.1
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.4 -0.1 -0.8 0.6 0.9 0.5 0.2 -0.5 0.4 -1.0 -0.3 0.3 1.2
Ever had hysterectomy (womb removed) 0.4 0.5 1.6 -1.1 -1.3 -0.2 0.2 0.3 -0.8 -0.6 -0.4 0.1 -0.8 -0.7 0.8
Systolic blood pressure, automated reading 0.5 1.6 2.9 0.1 1.7 1.4 1.3 1.6 0.7 -1.6 1.0 -0.1 1.7 0.4 1.4
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 1.9 -1.2 -1.0 0.7 1.2 1.4 0.5 -1.3 0.6 -0.5 -0.3 -0.2 1.3
Angina 0.7 0.9 1.9 -0.3 -1.0 -1.4 -1.0 -0.9 -0.9 1.0 -0.8 1.1 -0.6 -1.0 -0.7
Medication for hormone replacement therapy 0.2 0.2 0.5 -0.7 -0.2 -0.6 0.0 0.2 0.1 -0.4 -0.3 0.5 -0.6 -0.7 0.3
Vitamin and mineral supplements 4.4 6.0 8.6 -1.3 -2.3 -2.5 -2.5 -2.7 -2.9 2.6 -2.9 1.4 -2.9 -2.4 -2.5
Supplements: Zinc 1.6 1.8 5.1 1.5 2.3 1.6 0.8 0.3 1.4 -0.0 1.4 -1.1 1.7 1.5 0.3
Medication: Co-codamol 0.8 1.0 3.8 -0.5 -1.2 0.8 1.0 1.4 -0.1 -1.2 0.3 -0.8 -0.4 -0.0 1.9
Medication: Metformin 1.0 1.4 4.6 0.2 -0.5 -1.2 -1.0 -2.1 -1.1 1.6 -0.5 0.9 0.4 -0.3 -2.1
Diabetes (father) 0.3 0.4 1.7 -0.7 -0.1 0.1 0.3 1.0 0.4 -1.3 -0.3 0.5 -0.0 -0.3 0.8
Diabetes (mother) 1.1 1.4 3.1 -0.2 -0.6 -1.3 -1.3 -1.7 -0.9 1.6 -1.2 1.1 -0.2 -0.9 -1.8
Severe depression (siblings) 0.8 0.8 1.6 -0.7 1.0 -1.0 -1.1 -0.7 -0.8 0.8 -1.2 0.8 -0.7 -0.7 -1.2
Pack years adult smoking proportion 0.2 0.4 0.8 0.5 -0.9 0.4 0.9 0.6 0.2 -0.9 0.7 0.0 0.6 0.1 0.6
Impedance of leg (right) 0.6 2.8 8.6 2.9 1.7 1.0 0.3 -1.9 1.6 1.3 1.2 -1.5 1.7 2.0 -1.6
Leg fat-free mass (left) 0.3 1.4 3.7 -1.1 -0.1 1.1 1.6 1.9 0.2 -1.7 0.9 -0.9 -0.1 0.3 1.9
Trunk fat percentage 0.3 1.2 4.0 -1.1 -0.9 -1.0 -1.2 -0.7 -2.0 0.8 -1.2 0.9 -0.8 -1.2 -0.7
Hand grip strength (right) 1.8 4.8 6.9 1.4 2.4 2.6 2.5 1.6 2.6 -1.6 2.5 -2.1 1.9 2.0 2.5
Townsend deprivation index at recruitment 0.8 1.1 3.2 0.5 -0.8 0.8 1.1 1.1 1.5 -1.4 1.0 -0.4 0.6 0.6 1.8
Current tobacco smoking 2.5 4.0 11.6 1.5 -0.0 2.1 2.4 1.2 3.4 -1.7 2.4 -1.8 1.9 2.0 1.9
Average weekly fortified wine intake 0.8 0.9 2.6 -1.6 0.3 -0.8 -0.7 0.5 -1.0 -0.4 -1.1 1.4 -0.7 -1.4 0.6
Maternal smoking around birth 1.0 1.4 3.0 -0.2 1.5 0.8 1.7 1.3 1.0 -1.6 1.3 -0.6 0.7 0.5 1.7
Fed-up feelings 0.5 0.8 2.0 -0.5 -1.2 -1.3 -1.0 -0.4 -0.9 0.1 -1.0 1.4 -0.4 -0.9 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 1.5 -0.3 -1.2 -0.5 -0.7 0.1 0.3 0.3 -0.4 0.4 -0.2 -0.3 -0.5
Relative age voice broke 0.4 0.6 1.9 0.8 -0.7 0.0 -0.1 -1.2 -0.5 1.2 0.2 -0.7 -0.2 0.5 -1.4
Taking other prescription medications 0.3 0.5 2.0 1.0 0.2 0.7 0.4 0.1 0.7 -0.0 0.8 -0.5 1.4 0.9 0.2
Age when periods started (menarche) 0.1 0.2 1.0 -0.1 -0.5 0.7 0.6 1.0 -0.0 -0.6 0.3 -0.3 -0.1 0.3 0.4
Bilateral oophorectomy (both ovaries removed) 1.1 1.2 3.0 -1.4 -1.7 0.6 1.1 1.3 -0.3 -1.4 0.1 -0.5 -1.1 -0.5 1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 0.9 -0.1 0.9 0.1 0.6 0.7 0.9 -0.9 0.5 0.4 0.7 0.2 0.6
Tinnitus: Yes, but not now, but have in the past 2.3 2.4 4.8 -1.6 -1.2 -1.8 -1.4 -0.5 -2.2 0.6 -2.2 1.6 -1.7 -1.9 -1.1
Qualifications: CSEs or equivalent 0.1 0.1 0.6 0.2 -0.3 -0.1 -0.2 -0.8 0.2 0.6 -0.4 -0.3 -0.4 -0.2 -0.2
Serious illness, injury or assault to yourself 0.0 0.1 0.2 0.3 0.1 -0.2 -0.2 -0.0 0.4 0.2 0.1 -0.2 -0.2 0.3 0.0
High blood pressure 0.4 1.2 4.0 -0.7 0.3 -1.4 -1.1 -0.4 -1.7 0.4 -1.1 2.0 0.0 -1.5 -0.7
Hayfever, allergic rhinitis or eczema 1.9 4.1 8.6 -1.7 -1.4 -2.5 -2.2 -1.2 -2.9 1.5 -2.4 1.8 -2.3 -2.1 -1.7
Multivitamins +/- minerals 2.7 3.4 5.2 1.2 2.2 1.9 1.8 1.5 2.1 -1.6 2.3 -1.5 2.1 2.0 1.7
Stomach or abdominal pain in last month 0.1 0.2 0.5 -0.5 -0.2 -0.3 -0.5 0.6 0.0 -0.2 -0.4 0.7 0.0 -0.5 0.3
Supplements: Glucosamine 1.2 1.5 5.5 -1.2 -0.2 0.8 1.4 2.4 0.1 -1.8 1.0 -0.2 0.3 0.2 2.1
Diverticular disease/diverticulitis (self-reported) 2.3 2.8 5.4 -0.7 -0.6 -1.9 -1.9 -2.0 -2.3 2.1 -1.6 0.9 -1.4 -1.2 -2.2
Medication: Atenolol 0.7 0.9 2.1 -0.5 -0.4 -1.2 -1.1 -0.9 -1.4 0.9 -0.8 0.9 -0.8 -0.9 -1.0
Medication: Levothyroxine sodium 0.5 0.8 3.1 1.0 0.3 -0.0 -0.5 -1.8 -0.4 1.4 -0.3 -0.5 0.1 0.5 -1.6
Sitting height 1.3 9.4 15.3 2.4 3.5 3.9 3.6 1.3 3.2 -1.6 3.7 -3.9 2.5 3.8 1.6
Chronic bronchitis/emphysema (father) 0.6 0.7 2.3 -0.9 -1.1 0.7 0.7 1.0 -0.3 -1.5 0.1 -0.2 0.2 -0.1 1.5
High blood pressure (mother) 1.5 2.2 6.2 1.1 0.7 -1.7 -1.7 -2.5 -1.0 2.2 -0.6 1.2 0.5 -0.4 -2.1
Body mass index (BMI) 0.7 2.9 8.0 -2.8 -2.2 -1.2 -0.6 1.3 -2.0 -0.9 -1.4 1.9 -1.3 -2.3 1.2
Impedance of leg (left) 0.6 3.1 9.5 3.1 1.7 1.0 0.0 -2.1 1.6 1.7 1.1 -1.6 1.6 2.1 -2.0
Leg predicted mass (left) 0.3 1.4 3.6 -1.1 -0.0 1.1 1.6 1.9 0.2 -1.6 1.0 -0.9 -0.0 0.3 1.9
Trunk fat mass 0.1 0.5 2.1 -1.2 -0.6 -0.4 -0.4 0.1 -1.5 0.1 -0.6 0.5 -0.5 -0.8 0.1
Waist circumference 0.3 1.0 2.9 -1.7 -1.7 -0.3 -0.1 0.1 -1.5 -0.2 -0.9 0.0 -1.3 -1.0 0.3
Number of incorrect matches in round 1.7 2.8 5.8 -1.3 -2.4 -2.0 -2.1 -0.0 -1.8 0.2 -2.1 2.2 -0.9 -1.9 -0.6
Past tobacco smoking 1.4 2.5 5.1 0.1 -1.2 -2.0 -2.3 -1.9 -1.3 2.0 -1.5 1.4 -1.0 -1.1 -2.1
Alcohol usually taken with meals 0.9 1.5 3.9 1.0 0.8 1.7 1.4 0.8 0.7 -0.4 1.4 -2.0 1.0 1.8 0.6
Nervous feelings 6.6 12.3 21.7 -1.7 -1.2 -4.3 -4.7 -3.6 -3.5 3.5 -4.2 3.8 -2.3 -3.3 -4.1
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 3.8 -1.5 -1.6 -0.9 -0.8 1.3 -0.4 -1.0 -1.0 2.0 -0.6 -1.4 0.5
Hearing difficulty/problems with background noise 2.5 4.0 7.9 -1.5 -1.9 -2.2 -2.5 -1.5 -2.1 1.4 -2.8 2.0 -1.7 -2.3 -1.6
Hair/balding pattern: Pattern 2 0.6 0.8 3.4 -0.6 -0.6 1.0 0.5 1.6 0.6 -0.7 0.3 -0.6 -0.1 0.1 1.8
Had menopause 0.9 1.1 4.2 -2.0 -0.7 -0.3 0.0 1.5 -0.9 -1.4 -0.6 0.7 -0.6 -0.9 1.1
Had other major operations 0.1 0.1 0.9 0.2 -1.0 0.1 -0.0 -0.4 -0.1 0.2 0.0 -0.3 -0.1 0.0 0.3
Forced vital capacity (FVC) 1.6 6.1 12.0 3.4 2.2 2.6 1.8 -1.3 2.7 1.1 2.9 -3.2 2.2 3.5 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 1.3 0.4 0.5 0.7 0.8 0.7 1.1 -0.9 0.9 -0.2 1.0 0.8 0.8
Ever unenthusiastic/disinterested for a whole week 3.0 3.7 6.5 -1.5 -2.0 -2.5 -2.1 -1.2 -2.3 1.4 -2.0 2.0 -1.9 -1.9 -1.8
Qualifications: None of the above 0.3 0.7 2.2 -0.4 -1.5 -1.1 -0.9 -0.6 -0.5 0.6 -0.6 1.0 -0.3 -0.7 -0.6
Financial difficulties in last 2 years 1.1 1.4 3.6 0.8 1.0 1.3 1.4 0.8 1.5 -1.1 1.3 -0.5 1.9 0.8 1.2
Mouth/teeth dental problems 0.2 0.3 1.0 -0.6 0.6 -1.0 -0.3 -0.2 -0.1 0.3 -0.4 0.5 -0.9 -0.7 0.0
Heart attack 2.5 3.2 7.0 -1.5 -1.3 -2.6 -1.8 -0.2 -2.2 0.1 -2.1 2.5 -1.8 -2.2 -1.0
Allergy 2.2 5.0 10.1 1.6 2.3 2.8 2.4 1.3 3.2 -1.7 2.5 -1.9 2.5 2.2 1.8
Pain all over the body in last month 0.6 0.6 1.4 1.0 1.2 0.2 -0.6 -1.0 0.8 1.0 0.1 0.0 1.0 0.4 -0.7
Diabetes (self-reported) 0.1 0.1 0.5 -0.3 0.0 -0.2 0.0 -0.5 -0.7 -0.0 -0.2 0.3 0.2 -0.3 -0.7
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 3.2 -1.0 -1.8 -1.4 -0.9 0.0 -1.4 0.1 -1.2 1.1 -1.4 -1.1 -0.6
Medication: Ramipril 0.1 0.1 0.5 -0.4 -0.5 -0.1 0.4 0.1 -0.1 -0.7 0.1 0.4 0.3 -0.3 0.1
Medication: Simvastatin 0.4 0.6 1.7 -1.1 -1.2 -0.7 -0.2 -0.2 -1.3 -0.1 -0.8 0.4 -1.0 -0.8 -0.3
Fluid intelligence score 0.4 0.8 2.0 -0.1 1.4 0.9 1.2 0.7 0.4 -0.9 1.0 -0.9 0.3 0.7 1.0
Illnesses of siblings 0.7 1.0 2.3 -0.8 -0.9 -1.2 -1.4 -0.5 -0.4 0.9 -1.2 0.8 -1.5 -1.0 -0.9
Neuroticism score 2.5 5.2 8.7 -2.1 -1.9 -2.9 -2.4 -0.9 -2.9 0.9 -3.0 2.7 -2.0 -2.7 -1.6
Weight 0.1 0.6 1.5 -1.2 -0.7 0.6 1.0 1.2 -0.6 -1.0 0.3 -0.4 -0.2 -0.2 1.2
Impedance of arm (right) 1.1 5.3 14.8 3.4 2.2 -0.1 -1.0 -3.9 0.6 3.3 0.4 -1.5 0.8 1.9 -3.7
Arm fat percentage (right) 0.7 2.8 6.2 -1.8 -1.9 -1.8 -1.6 -0.5 -2.5 0.8 -1.8 1.9 -1.2 -2.1 -0.7
Trunk fat-free mass 0.7 4.0 8.4 -0.6 0.3 2.4 2.9 2.8 1.2 -2.6 2.0 -1.7 0.8 1.2 2.8
Hip circumference 0.2 0.6 1.5 -0.5 -0.1 1.0 1.1 1.1 -0.1 -1.0 0.8 -0.6 0.8 0.3 1.2
Time employed in main current job 0.7 0.8 2.7 1.0 -0.6 0.0 -0.2 -1.6 -0.0 1.3 0.3 -1.0 -0.4 0.7 -1.4
Alcohol intake versus 10 years previously 0.9 1.4 4.0 1.9 1.1 0.8 0.5 -1.1 1.1 0.7 1.3 -0.7 2.0 1.3 -0.8
Father’s age at death 0.6 0.8 2.5 1.4 1.6 0.3 -0.4 -0.6 0.6 0.8 0.4 0.1 1.5 0.7 -0.6
Worrier / anxious feelings 2.5 4.7 9.2 -1.6 -0.9 -2.9 -2.5 -1.5 -2.5 1.1 -3.0 2.6 -1.8 -2.3 -2.2
Frequency of tiredness / lethargy in last 2 weeks 2.8 4.5 9.9 -1.5 -0.8 -3.1 -2.7 -1.0 -1.9 1.3 -2.6 2.9 -1.6 -2.6 -1.8
Falls in the last year 2.0 2.7 7.3 -0.5 -0.3 1.4 2.0 2.7 1.3 -2.6 1.4 -1.0 0.8 1.0 2.5
Hair/balding pattern: Pattern 3 3.5 5.2 8.3 -1.8 -2.5 -2.9 -2.2 -1.3 -2.9 0.9 -2.8 2.7 -1.9 -2.5 -2.1
Number of live births 0.8 1.1 4.5 -1.2 -2.1 -0.5 -0.5 -0.1 -1.3 0.1 -1.4 0.2 -1.7 -0.9 -0.1
Forced expiratory volume in 1-second (FEV1) 1.2 4.2 8.2 2.7 2.2 2.1 1.3 -1.3 2.0 1.3 2.2 -2.9 1.4 2.8 -0.9
Pulse rate 0.7 1.1 3.0 0.3 -0.8 1.3 1.3 1.0 1.3 -0.8 0.8 -1.4 0.5 0.6 1.7
Happiness 0.5 0.6 2.0 -0.3 -0.3 -1.0 -0.7 -1.0 -0.8 0.7 -0.8 0.3 -0.7 -0.2 -1.4
Noisy workplace 3.3 4.1 8.4 -2.7 -2.9 -1.7 -2.0 0.1 -2.1 0.7 -2.6 1.6 -2.6 -2.5 -0.1
Qualifications: A levels/AS levels or equivalent 0.3 0.6 5.5 0.5 2.4 0.4 0.5 0.3 0.0 -0.3 0.3 -0.8 0.1 0.7 0.3
Serious illness, injury or assault of a close relative in last 2 years 2.6 3.0 5.7 -1.1 -0.3 -2.4 -1.9 -2.0 -1.9 1.3 -1.8 2.0 -1.2 -1.8 -1.9
Mouth/teeth dental problems: Dentures 0.7 1.1 3.7 -1.2 -1.5 0.4 0.4 1.9 -0.2 -1.6 -0.1 0.8 -0.0 -0.5 1.5
Asthma 1.1 2.2 4.3 -1.6 -2.1 -1.6 -1.2 -0.0 -2.0 0.4 -1.8 1.4 -1.6 -1.8 -0.3
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.8 1.1 1.1 0.2 0.0 -0.4 1.0 0.5 0.9 0.1 1.4 0.7 -0.8
Medication: Cholesterol lowering 0.7 1.1 2.7 -0.3 -0.7 -1.7 -1.1 -0.8 -1.3 0.7 -0.9 1.6 -0.1 -0.9 -1.5
Depression (self-reported) 3.2 3.8 7.2 -1.6 -1.1 -2.4 -2.7 -1.1 -1.9 1.4 -2.6 1.8 -2.3 -1.9 -1.7
Medication: Lansoprazole 0.2 0.2 0.9 -0.2 -0.8 0.2 -0.1 1.0 0.2 -0.5 -0.0 -0.1 -0.1 0.0 0.7
Prospective memory result 2.3 2.9 5.5 -2.2 -2.0 -1.7 -1.5 0.8 -1.5 -0.1 -2.0 2.2 -1.6 -2.3 0.2
Lung cancer (father) 1.1 1.3 3.8 -1.8 -1.9 -0.6 -0.2 0.5 -1.0 -0.8 -1.1 0.3 -2.0 -0.9 0.5
Illnesses of mother 1.3 1.6 4.5 -0.4 0.6 1.5 1.8 2.1 1.1 -1.6 1.2 -0.8 0.1 0.4 1.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.9 9.6 2.4 1.9 2.3 1.9 -0.5 2.1 0.4 2.3 -3.1 1.0 2.8 -0.1
Pulse wave Arterial Stiffness index 0.6 0.7 3.6 0.2 -1.9 0.8 0.4 0.8 1.0 -0.3 0.8 -0.6 0.4 0.5 0.9
Impedance of arm (left) 1.3 5.8 16.5 3.6 1.8 0.1 -1.1 -4.1 0.5 3.6 0.4 -1.9 0.8 2.1 -3.7
Arm fat mass (right) 0.4 1.5 3.6 -1.9 -1.6 -0.9 -0.6 0.5 -1.9 -0.3 -1.0 1.3 -1.0 -1.6 0.3
Trunk predicted mass 0.8 4.4 9.1 -0.6 0.3 2.5 3.0 3.0 1.3 -2.8 2.1 -1.8 0.8 1.3 2.9
Standing height 1.0 10.1 23.0 3.2 3.1 4.0 3.5 0.1 3.1 -0.5 3.8 -4.8 2.4 4.5 0.5
Length of working week for main job 1.8 2.0 4.2 0.4 -2.1 1.7 1.6 0.8 1.7 -0.9 1.3 -2.0 -0.0 1.1 1.5
Exposure to tobacco smoke at home 5.9 6.6 10.9 -1.6 -2.2 -3.3 -3.2 -2.1 -2.5 2.3 -3.0 2.6 -2.4 -2.8 -2.3
Breastfed as a baby 1.4 1.7 6.2 0.8 2.0 0.9 1.3 0.6 0.4 -1.3 1.8 0.4 2.5 1.2 0.1
Tense / ‘highly strung’ 4.7 7.8 12.4 -3.5 -2.1 -3.3 -2.6 -0.0 -3.5 0.6 -3.4 3.4 -3.2 -3.5 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 3.3 0.3 1.5 -1.7 -1.7 -0.9 -0.8 1.3 -0.9 1.5 0.0 -0.8 -1.8
Hair/balding pattern: Pattern 4 0.2 0.6 2.7 0.1 1.6 -0.7 -0.7 -0.8 -0.9 0.7 -0.6 0.4 -0.2 -0.4 -0.6
Birth weight of first child 0.5 0.9 3.4 0.0 -0.7 -0.6 -1.8 -0.8 -0.7 1.1 -1.3 1.0 -0.1 -0.9 -0.7
Peak expiratory flow (PEF) 0.4 0.8 2.9 0.5 0.8 1.2 1.1 0.3 0.7 -0.0 1.0 -1.7 -0.1 1.3 0.5
Pulse wave reflection index 1.3 1.6 3.0 1.1 -0.4 1.5 1.3 0.8 1.7 -0.9 1.7 -1.2 1.4 1.4 1.2
Ever highly irritable/argumentative for 2 days 0.7 0.9 3.1 -1.8 -1.5 -0.4 -0.1 0.7 -1.0 -0.4 -0.7 0.4 -1.4 -0.8 -0.1
Loud music exposure frequency 1.1 1.2 3.1 -1.4 -1.8 -1.2 -0.7 0.7 -0.9 -0.1 -0.9 1.4 -1.0 -1.3 -0.2
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 1.5 0.1 1.2 0.7 0.5 0.6 0.6 -0.8 0.0 -0.3 0.3 0.1 1.0
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 2.7 -0.2 -1.6 -0.6 -1.1 -1.1 -1.3 1.3 -1.1 0.1 -1.0 -0.5 -1.4
Blood clot in the leg (DVT) 1.9 2.4 6.0 -1.3 -0.9 -1.8 -1.9 -0.9 -1.6 1.1 -2.2 1.0 -2.5 -1.6 -0.9
Medication: Paracetamol 0.2 0.3 1.0 -0.1 -0.2 -0.3 -1.0 -0.1 -0.7 0.3 -0.6 0.9 0.1 -0.6 -0.2
Headache pain in last month 0.6 1.1 2.3 -1.3 -0.8 -1.2 -1.0 0.4 -0.9 -0.1 -1.3 1.5 -0.9 -1.3 0.0
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 4.8 1.0 1.0 1.9 1.4 0.2 1.6 -0.1 1.4 -2.2 0.6 1.6 0.8
Glaucoma (self-reported) 0.5 0.6 4.0 0.5 2.0 0.3 -0.2 0.1 0.4 -0.1 0.4 0.4 1.2 0.6 -0.5
Gout (self-reported) 1.5 2.0 4.8 -0.1 0.0 -1.9 -1.4 -1.8 -1.7 1.3 -1.4 1.4 -0.7 -1.2 -2.2
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 2.1 1.1 0.7 0.1 -0.6 -1.5 0.0 1.0 -0.1 -0.1 0.9 0.5 -1.3
Medication: Amlodipine 1.2 1.7 6.0 -1.5 0.6 -1.4 -1.2 1.0 -1.2 -0.8 -1.6 2.4 -0.6 -1.8 -0.1
Medication: Ventolin 100micrograms inhaler 0.6 0.8 3.5 -1.5 -1.9 -0.4 0.2 0.9 -0.9 -0.6 -0.3 0.6 -0.6 -0.9 0.5
Birth weight 0.3 0.8 1.8 0.6 1.3 1.2 0.6 0.2 0.9 -0.4 0.8 -0.9 1.0 1.2 0.2
Chronic bronchitis/emphysema (mother) 1.2 1.4 4.0 -1.5 -0.8 -1.3 -0.9 -0.2 -2.0 0.3 -1.4 0.8 -1.6 -1.0 -1.0
High blood pressure (siblings) 1.2 1.7 4.4 1.1 1.9 1.4 1.2 0.7 1.0 -0.9 1.5 -0.7 2.1 1.3 1.1
Forced vital capacity (FVC), Best measure 1.3 4.6 9.9 2.8 1.6 2.4 2.1 -0.8 2.4 0.6 2.6 -3.1 1.5 3.1 -0.5
Body fat percentage 0.5 1.8 4.6 -1.5 -1.5 -1.3 -1.4 -0.5 -2.1 0.7 -1.4 1.4 -0.9 -1.7 -0.6
Leg fat percentage (right) 0.6 2.1 4.8 -2.2 -1.8 -1.2 -1.0 0.5 -1.8 -0.2 -1.3 2.1 -0.5 -2.1 0.3
Arm fat-free mass (right) 0.7 3.8 10.3 -1.2 -0.2 2.0 2.6 3.2 0.8 -2.9 1.6 -1.4 0.2 0.7 3.2
Exposure to tobacco smoke outside home 1.1 1.5 4.4 2.1 1.2 -0.2 -0.1 -1.9 0.9 1.4 0.7 -0.5 1.3 1.1 -1.7
Comparative body size at age 10 0.6 1.8 4.8 2.2 1.9 0.9 -0.2 -1.4 1.2 1.6 1.0 -0.9 1.7 1.1 -0.6
Number of full brothers 0.8 1.0 3.3 1.3 0.4 -0.4 -1.1 -1.6 -0.2 1.8 -0.4 -0.2 0.4 0.2 -1.3
Worry too long after embarrassment 2.4 4.0 9.2 -2.7 -1.4 -2.4 -1.5 -0.3 -3.0 0.2 -2.3 2.5 -1.9 -2.5 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.8 0.7 0.3 0.5 0.4 0.4 1.3 -0.2 1.0 -0.2 0.9 0.8 0.3
Wheeze or whistling in the chest in last year 3.1 5.5 13.1 -2.0 -3.6 -2.9 -2.3 -0.7 -2.3 1.2 -2.7 2.6 -2.1 -2.7 -1.4
Number of children fathered 2.0 2.3 5.9 -0.0 0.5 1.4 1.6 2.3 1.8 -2.4 1.1 -0.5 0.9 0.6 2.3
Reason for reducing amount of alcohol drunk: Health precaution 1.7 2.0 6.3 -2.3 -0.1 0.0 0.3 2.5 -1.2 -2.5 -0.9 0.9 -0.8 -0.8 1.5
Age at first live birth 1.1 2.0 7.9 1.1 2.8 1.6 1.6 0.4 0.5 -0.2 1.6 -1.4 1.4 1.6 -0.0
Pulse wave peak to peak time 0.6 0.7 4.3 0.1 2.1 -0.6 -0.3 -0.9 -0.7 0.4 -0.6 0.4 -0.3 -0.3 -1.1
Health satisfaction 0.3 0.4 0.8 -0.9 0.3 -0.5 -0.8 0.3 -0.6 0.1 -0.7 0.8 -0.4 -0.8 -0.3
Shortness of breath walking on level ground 2.1 2.5 4.4 -1.6 -2.1 -1.5 -1.7 -0.3 -2.1 0.5 -2.0 1.7 -1.6 -1.9 -0.8
Qualifications: College or University degree 0.2 0.8 2.0 -0.1 1.4 1.1 1.0 0.9 0.1 -0.6 0.8 -1.1 -0.2 0.6 1.3
Eye problems/disorders: None of the above 0.6 0.7 1.9 0.3 0.4 -1.2 -1.0 -1.2 -0.5 1.4 -0.4 0.4 -0.4 -0.2 -1.3
Mouth/teeth dental problems: Loose teeth 2.4 2.8 5.2 1.5 1.1 2.3 1.9 0.8 1.9 -1.7 1.8 -1.8 2.0 2.0 0.9
Emphysema/chronic bronchitis 0.8 0.8 2.0 0.1 0.0 0.5 1.4 1.3 0.8 -1.4 1.1 -0.0 0.8 0.2 1.3
Medication for pain relief, constipation, heartburn 0.6 1.0 2.4 1.1 1.0 1.1 1.0 0.1 1.4 -0.2 1.1 -1.5 0.5 1.2 0.8
Neck or shoulder pain in last month 0.9 1.2 2.9 -1.4 -1.7 -1.1 -1.0 0.6 -0.5 -0.5 -1.2 1.5 -0.9 -1.4 0.5
Medication: Blood pressure 0.8 1.4 5.5 -0.6 -1.3 -1.7 -1.2 0.1 -1.3 -0.2 -1.0 2.3 0.2 -1.4 -0.4
Angina (self-reported) 0.2 0.2 0.7 -0.1 -0.7 -0.8 -0.4 -0.4 -0.3 0.4 -0.2 0.7 -0.1 -0.6 -0.2
Migraine (self-reported) 2.5 3.0 9.5 0.1 -0.5 -1.7 -1.9 -2.5 -1.8 2.5 -1.5 0.8 -1.4 -0.7 -3.1
Medication: Ibuprofen 0.7 0.8 2.2 1.3 0.7 0.7 0.4 -0.2 1.5 0.3 1.1 -0.5 1.1 1.2 -0.7
Medication: Allopurinol 1.1 1.4 2.7 -0.6 0.1 -1.6 -1.2 -1.2 -1.4 0.4 -1.5 1.6 -0.8 -1.5 -1.2
Medication: Omeprazole 0.1 0.1 0.2 -0.1 -0.1 -0.4 -0.4 -0.5 -0.5 0.2 -0.4 0.3 -0.0 -0.3 -0.4
Medication: Seretide 50 evohaler 0.4 0.5 1.8 -1.4 -0.8 -0.5 0.9 0.4 -0.6 -0.8 0.1 0.4 -0.6 -0.6 0.4
Mean time to correctly identify matches 1.4 2.7 7.6 -1.6 0.7 -2.2 -1.5 -0.3 -2.4 -0.0 -1.8 2.8 -0.5 -2.1 -0.9
Heart disease (mother) 0.2 0.3 1.1 0.7 0.3 -0.3 -0.4 -1.0 -0.4 0.8 0.1 -0.0 0.5 0.3 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 4.2 -1.0 0.3 -1.4 -1.4 -0.3 -1.2 0.5 -1.2 2.0 -0.4 -1.4 -0.7
Whole body fat mass 0.2 0.8 2.6 -1.5 -1.2 -0.6 -0.4 0.3 -1.6 -0.1 -0.7 0.8 -0.5 -1.2 0.3
Leg fat mass (right) 0.3 1.1 3.2 -1.8 -1.2 -0.7 -0.2 0.8 -1.3 -0.6 -0.6 1.4 -0.3 -1.4 0.7
Arm predicted mass (right) 0.7 3.8 9.9 -1.2 -0.2 1.9 2.6 3.1 0.9 -2.9 1.6 -1.3 0.3 0.7 3.1
Pulse rate, automated reading 1.0 3.3 10.8 2.4 -0.3 2.0 1.7 -1.6 1.6 1.1 1.6 -3.3 0.9 2.4 -0.4
Alcohol intake frequency. 0.3 0.8 2.2 0.9 0.5 -0.2 -1.1 -1.5 0.3 1.5 -0.3 0.1 0.6 0.3 -1.4
Comparative height size at age 10 1.2 6.6 11.5 2.0 1.8 3.1 3.4 1.2 2.6 -2.1 3.2 -3.1 2.3 3.1 1.7
Number of full sisters 0.4 0.5 1.5 0.8 0.5 0.3 0.5 -0.8 0.2 0.6 0.7 -1.2 0.1 1.1 -0.8
Suffer from ‘nerves’ 10.3 16.2 25.6 -3.0 -2.7 -5.0 -4.5 -3.2 -5.1 3.6 -4.8 3.7 -4.1 -4.3 -3.5
Overall health rating 1.4 3.0 6.0 -0.3 -0.4 -2.2 -2.4 -2.0 -1.3 2.0 -1.7 2.1 -0.6 -1.5 -2.4
Chest pain or discomfort 0.2 0.3 3.2 0.1 -1.8 -0.5 -0.2 0.1 0.2 0.0 -0.2 0.1 -0.2 0.3 -0.6
Had major operations 0.9 1.0 2.8 -1.6 -1.4 -1.0 -0.4 0.2 -0.5 -0.1 -0.8 0.6 -1.7 -1.3 0.9
Age at last live birth 0.7 1.1 3.6 0.5 1.9 1.2 1.4 0.5 0.3 -0.4 1.4 -0.7 1.2 1.0 0.2
Family relationship satisfaction 0.4 0.5 1.1 0.6 1.0 0.3 0.8 -1.1 0.3 0.4 0.6 -1.0 0.3 0.7 -0.2
Leg pain on walking 0.6 0.8 2.7 -0.8 -0.1 0.9 0.4 1.6 -0.4 -1.4 -0.0 -0.0 0.1 -0.4 1.6
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 1.0 -0.2 -1.0 -0.1 0.6 0.2 0.2 -0.6 0.1 -0.1 -0.3 -0.2 0.4
Commuting to job workplace: Car/motor vehicle 0.3 0.4 1.2 -1.1 0.1 -0.8 -0.1 0.4 -0.4 -0.4 -0.3 1.1 -0.4 -0.8 -0.1
Illness, injury, bereavement, stress in last 2 years 0.1 0.2 0.4 -0.4 -0.5 0.1 -0.4 0.3 -0.4 -0.0 -0.6 0.2 -0.6 -0.5 0.1
Medication: Aspirin 0.1 0.2 0.6 -0.4 0.7 -0.4 -0.2 0.4 -0.4 -0.3 -0.1 0.8 0.1 -0.3 -0.4
Supplements: Vitamin C 1.3 1.5 4.8 -0.5 -0.7 1.0 1.0 2.2 1.0 -2.1 0.8 0.2 0.8 0.2 2.0
Knee pain experienced in last month 1.2 1.9 6.4 -1.4 -1.9 0.1 0.4 2.2 0.2 -2.1 -0.2 0.7 -0.3 -1.0 2.5
Hypertension (Self-reported) 0.4 1.0 3.0 -0.6 0.5 -1.1 -0.9 -0.5 -1.7 0.4 -1.0 1.7 0.0 -1.4 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 4.2 -1.9 -1.9 -0.4 -0.5 -0.0 -1.2 0.0 -1.4 -0.0 -2.0 -1.1 0.2
Illnesses of father: Heart disease 1.1 1.5 4.5 1.5 0.9 0.5 -0.4 -2.0 -0.1 2.1 0.1 -1.5 0.2 1.1 -1.6
Illnesses of siblings: Diabetes 0.2 0.3 0.6 0.2 0.5 -0.3 -0.5 -0.4 -0.6 0.6 -0.3 0.7 0.8 -0.3 -0.6
Smoking status: Previous 1.0 1.5 3.0 -0.6 1.4 1.4 1.7 1.7 0.6 -1.7 1.0 -0.9 0.4 0.6 1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.6 5.4 1.6 0.8 1.2 1.0 -1.0 1.5 0.8 1.3 -2.3 0.1 1.6 -0.6
Whole body fat-free mass 0.6 3.3 7.5 -1.0 0.1 2.0 2.5 2.7 0.8 -2.5 1.7 -1.5 0.4 0.9 2.7
Leg fat-free mass (right) 0.2 1.1 2.8 -1.0 -0.0 1.1 1.5 1.7 0.2 -1.5 0.8 -0.9 -0.1 0.3 1.7
Arm fat percentage (left) 0.7 2.8 6.4 -1.8 -2.0 -1.8 -1.7 -0.5 -2.5 0.8 -1.8 1.9 -1.2 -2.1 -0.6
Average weekly red wine intake 1.4 2.0 4.8 0.3 0.2 1.6 2.2 1.7 0.6 -1.6 1.5 -1.8 0.6 1.4 1.7
Handedness (chirality/laterality): Left-handed 1.0 1.3 6.0 1.9 1.2 0.3 0.2 -0.3 1.3 -0.1 1.1 0.6 2.4 0.7 -0.3
Mood swings 1.9 3.4 5.7 -1.4 -1.8 -2.4 -2.2 -0.9 -1.9 0.9 -2.3 2.4 -1.5 -2.2 -1.4
Loneliness, isolation 0.1 0.1 0.9 -0.0 -0.9 0.1 -0.2 -0.2 -0.1 0.1 -0.4 0.1 -0.2 -0.3 0.1
Long-standing illness, disability or infirmity 0.3 0.4 1.2 0.8 0.5 -0.5 -0.5 -0.8 -0.9 0.4 -0.1 0.7 0.8 0.1 -1.1
Ever had bowel cancer screening 1.8 2.1 7.3 0.5 -0.2 -1.5 -1.9 -1.9 -1.5 2.0 -0.9 1.0 0.0 -0.2 -2.7
Diabetes diagnosed by doctor 0.2 0.4 1.5 -0.4 0.3 -0.6 -0.1 -1.0 -0.8 0.2 -0.4 0.5 0.1 -0.4 -1.2
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 4.1 1.4 0.1 0.0 -0.1 -2.0 -0.5 1.8 0.5 -0.9 0.3 0.6 -1.4
Friendships satisfaction 0.1 0.1 0.4 0.1 0.2 -0.5 -0.3 -0.5 -0.2 0.4 -0.3 0.1 -0.1 0.1 -0.6
Qualifications: nursing, teaching 0.4 0.6 1.5 0.0 -0.0 -0.7 -1.0 -1.0 -0.5 1.1 -0.9 -0.0 -0.9 -0.2 -1.2
Commuting to job workplace: Walk 2.3 2.5 5.5 0.4 0.4 1.9 2.1 1.5 1.4 -2.0 1.4 -1.7 1.1 1.3 2.3
Eye problems/disorders: Cataract 1.0 1.2 4.4 -0.7 -0.3 1.0 1.5 1.6 0.5 -2.1 0.5 -0.4 0.1 0.3 1.6
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 3.7 -0.1 -1.9 -0.4 -0.7 -0.4 -0.4 0.9 -0.7 0.0 -0.8 -0.3 -0.4
Medication for cholesterol 0.8 1.3 2.7 1.6 0.8 1.3 0.7 0.4 1.6 -0.4 1.2 -0.9 1.5 1.6 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.3 -1.1 -1.0 -0.3 0.2 1.1 -0.0 -1.0 -0.3 1.0 0.1 -1.1 1.5
Back pain experienced in last month 1.2 1.7 3.2 0.7 0.2 1.2 1.5 1.6 1.4 -1.7 1.5 -0.3 1.8 1.0 1.6
Mineral and other dietary supplements 1.2 1.6 5.0 0.5 -0.4 -1.0 -1.5 -2.2 -0.6 2.0 -1.0 0.5 -0.6 -0.5 -2.2
Breast cancer (self-reported) 0.2 0.3 1.2 -0.5 -1.1 -0.1 -0.7 0.1 -0.5 -0.1 -0.7 0.5 -0.3 -0.7 0.4
Asthma (self-reported) 1.4 2.8 5.6 -1.9 -2.2 -1.9 -1.3 -0.2 -2.4 0.5 -2.0 1.6 -1.8 -2.0 -0.6
Osteoporosis (self-reported) 1.4 1.8 3.7 -1.0 -1.1 -1.8 -1.7 -0.4 -1.6 0.7 -1.3 1.9 -0.9 -1.5 -1.0
Osteoarthritis (self-reported) 0.3 0.4 1.5 0.1 0.4 0.4 -0.0 1.2 0.8 -0.9 0.5 0.4 0.7 0.1 1.0
Medication: Aspirin 0.2 0.2 0.9 -0.4 0.4 -0.5 -0.2 0.3 -0.6 -0.3 -0.2 0.9 0.1 -0.5 -0.5
Medication: Gliclazide 0.9 1.0 2.0 -0.9 -1.4 -1.0 -0.4 -0.9 -1.2 0.9 -0.8 0.3 -1.3 -0.7 -1.3
Illnesses of father: None of the above (group 1) 0.3 0.4 0.9 -0.2 -0.7 -0.1 0.4 0.9 0.9 -0.8 0.5 0.6 0.3 -0.0 0.7
Smoking status: Current 2.5 3.9 10.1 1.4 -0.2 2.1 2.5 1.3 3.2 -1.7 2.4 -1.7 1.9 1.9 1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.8 0.9 0.4 0.2 -0.0 0.1 0.4 0.2 0.4 -0.3 0.6 0.6 0.0
Whole body water mass 0.6 3.3 7.7 -1.0 0.1 2.0 2.5 2.8 0.8 -2.5 1.6 -1.5 0.4 0.9 2.8
Leg predicted mass (right) 0.2 1.2 3.0 -1.0 -0.0 1.2 1.6 1.7 0.2 -1.5 0.9 -0.9 -0.1 0.3 1.7
Arm fat mass (left) 0.3 1.4 3.5 -1.9 -1.7 -0.8 -0.5 0.6 -1.9 -0.3 -0.9 1.1 -0.9 -1.5 0.5
Number of self-reported non-cancer illnesses 2.8 4.8 9.7 -1.6 -0.9 -3.0 -2.3 -1.4 -3.1 1.4 -2.5 2.5 -1.9 -2.4 -2.0
Average weekly champagne plus white wine intake 0.1 0.1 0.4 0.1 -0.3 -0.1 0.4 -0.2 -0.6 -0.0 0.1 0.0 -0.2 0.2 -0.6
Miserableness 2.5 4.3 7.6 -1.4 -1.2 -2.4 -2.8 -1.8 -2.6 1.6 -2.7 2.1 -1.6 -2.1 -1.8
Guilty feelings 0.4 0.5 4.6 -0.2 -2.1 -0.2 -0.0 0.5 -0.0 -0.6 -0.2 0.2 -0.1 -0.2 1.0
Wears glasses or contact lenses 1.6 1.9 4.0 -1.7 -2.0 -1.3 -1.3 0.7 -1.7 -0.1 -1.6 1.2 -1.5 -1.5 0.5
Ever taken oral contraceptive pill 1.9 2.2 3.7 1.6 1.3 1.6 1.6 0.9 1.6 -0.8 1.9 -1.6 1.5 1.8 0.9
Hearing aid user 2.0 2.2 5.8 -1.0 0.2 -1.7 -2.4 -1.5 -0.8 1.5 -2.2 1.3 -1.3 -1.3 -1.3
Mother’s age at death 0.8 1.0 2.6 -0.9 0.0 -1.0 -1.4 -0.4 -1.6 1.0 -1.1 0.9 -0.7 -0.7 -1.2
Financial situation satisfaction 0.6 0.7 1.6 -0.3 -1.0 -1.2 -1.3 -0.4 -0.5 0.8 -1.0 0.8 -0.6 -0.7 -0.8
Tinnitus: Yes, now most or all of the time 2.5 2.9 6.8 -1.0 0.2 -1.8 -1.8 -1.7 -2.6 1.9 -1.8 1.0 -1.6 -1.1 -2.4
Commuting to job workplace: Public transport 2.1 2.5 4.8 1.9 0.9 2.2 1.3 0.4 2.0 -0.5 1.9 -1.7 2.0 2.0 0.5
Eye problems/disorders: Glaucoma 0.3 0.3 0.9 0.1 1.0 -0.3 -0.8 -0.4 -0.2 0.1 -0.5 0.9 0.5 -0.2 -0.7
Medication: Blood pressure 0.2 0.4 1.0 -0.7 0.6 -0.5 -0.3 -0.7 -1.0 0.8 -0.3 0.4 -0.5 -0.8 -0.2
Pain type(s) experienced in last month: Hip pain 3.2 4.0 13.3 -1.9 -2.2 1.1 1.9 3.7 0.1 -3.3 0.5 -0.1 -0.7 -0.4 3.1
Supplements: Fish oil (including cod liver oil) 0.6 0.8 3.0 -0.7 -0.2 0.4 1.0 1.7 -0.0 -1.6 0.3 0.1 0.1 -0.0 1.6
High cholesterol (Self-reported) 1.2 2.1 7.6 0.9 0.5 -1.4 -1.5 -2.5 -0.7 2.3 -0.7 0.6 -0.0 -0.2 -2.8
Medication: Bendroflumethiazide 0.6 1.0 2.6 -0.8 -1.1 -1.1 -0.7 -0.4 -1.6 0.3 -0.9 1.6 -0.3 -1.5 -0.0
Medication: Paracetamol 0.3 0.4 1.4 0.3 0.3 -0.5 -1.2 -0.7 -0.3 0.8 -0.6 0.9 0.3 -0.4 -0.8
Medication: Lisinopril 0.8 1.1 2.6 -0.4 -0.3 -1.3 -1.6 -0.6 -1.0 0.9 -1.1 1.6 -0.2 -1.1 -1.3
Medication: Atorvastatin 0.4 0.5 1.8 0.8 0.5 -0.5 -0.0 -0.8 0.0 0.6 0.8 0.5 1.3 0.3 -1.2
Illnesses of father: High blood pressure 0.8 1.0 8.4 1.0 2.9 -0.3 -0.4 -0.6 -0.5 0.7 0.2 0.7 1.0 -0.2 -0.6
Alcohol drinker status: Never 0.1 0.1 0.3 0.4 0.6 0.3 -0.2 0.0 0.4 -0.1 -0.1 -0.1 0.4 0.1 -0.1
Ever smoked 0.8 1.4 2.5 0.8 1.1 1.6 1.4 0.8 1.5 -0.7 1.3 -1.5 0.9 1.2 1.1
Basal metabolic rate 0.4 2.4 5.7 -0.9 -0.0 1.7 2.2 2.4 0.5 -2.1 1.4 -1.3 0.3 0.6 2.4
Leg fat percentage (left) 0.6 2.3 5.0 -2.2 -2.0 -1.2 -1.1 0.5 -1.9 -0.0 -1.5 2.0 -0.8 -2.1 0.3
Arm fat-free mass (left) 0.7 3.5 9.5 -1.1 -0.1 2.0 2.5 3.1 0.8 -2.8 1.5 -1.2 0.4 0.7 2.9
Number of operations (self-reported) 0.3 0.5 2.1 0.7 -1.4 0.0 0.2 -0.7 0.2 0.9 0.6 -0.9 -0.1 0.6 0.2
Average weekly beer plus cider intake 2.1 3.0 11.0 1.9 0.9 -1.4 -1.5 -3.3 -0.2 2.6 -0.1 1.3 1.1 -0.5 -2.7
Irritability 0.6 1.0 2.7 -0.6 -0.7 -1.3 -1.3 -0.1 -1.1 0.3 -1.1 1.6 -0.3 -1.3 -0.5
Risk taking 2.0 3.0 7.1 -0.1 -1.6 1.5 2.1 2.6 1.4 -2.5 1.4 -1.2 0.1 0.8 2.7
Ever had prostate specific antigen (PSA) test 1.3 1.5 3.0 1.2 1.2 1.1 1.3 0.8 1.1 -0.5 1.6 -1.4 1.5 1.7 0.3
Fractured/broken bones in last 5 years 0.1 0.2 0.4 0.6 -0.1 -0.2 0.0 -0.4 -0.6 0.6 0.3 -0.2 -0.1 0.4 -0.6
Age started oral contraceptive pill 0.5 0.6 1.7 -1.2 0.2 -0.8 -0.6 0.6 -1.3 -0.1 -0.6 1.2 -0.5 -0.8 -0.3
Diastolic blood pressure, automated reading 0.2 0.6 2.0 0.9 0.7 1.1 0.6 0.3 0.4 -0.1 0.7 -0.6 1.4 0.7 0.5
Ever depressed for a whole week 1.8 2.2 6.0 -1.9 -2.4 -1.3 -0.8 1.0 -1.6 -0.7 -1.4 1.4 -1.6 -1.7 0.7
Unable to work because of sickness or disability 2.2 2.8 7.1 1.5 -0.0 2.0 1.6 1.3 2.7 -1.5 2.0 -1.3 1.8 1.9 1.3
Commuting to job workplace: Cycle 0.4 0.5 1.7 -1.0 -1.3 -0.2 -0.6 0.6 -0.6 -0.2 -0.7 0.4 -1.0 -0.8 0.6
Myopia 0.1 0.2 0.7 -0.3 0.8 -0.2 -0.1 -0.2 -0.6 -0.3 -0.5 0.3 -0.1 -0.4 0.1
Vascular/heart problems diagnosed by doctor 1.1 2.9 7.7 1.4 0.6 2.2 1.7 0.8 2.4 -0.6 1.8 -2.8 0.7 2.3 1.2
Cholesterol lowering medication 0.6 0.9 2.0 -0.6 -1.0 -0.9 -0.8 -1.2 -1.4 1.2 -0.8 0.2 -1.0 -0.7 -1.3
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.3 -0.7 -1.2 -0.8 -0.9 -0.6 -0.9 0.4 -1.1 0.6 -0.7 -1.0 -0.2
Pain experienced in last month 0.6 1.0 2.0 1.4 1.2 0.5 0.2 -1.2 0.3 1.1 0.5 -1.4 0.2 1.3 -1.4
Supplements: Calcium 0.2 0.3 0.8 0.5 0.9 0.5 0.3 0.1 0.7 -0.2 0.4 -0.5 0.5 0.6 0.1
Basal cell carcinoma (self-reported) 0.5 0.6 1.8 -0.1 0.5 -0.9 -0.7 -1.1 -0.8 0.6 -1.1 0.4 -0.7 -0.3 -1.4
Heart attack/myocardial infarction (self-reported) 2.8 3.6 8.1 -1.5 -1.4 -2.8 -1.8 -0.3 -2.3 0.1 -2.1 2.7 -1.8 -2.3 -1.1
Deep venous thrombosis (DVT) (self-reported) 2.8 3.6 8.5 -1.7 -1.3 -2.2 -2.3 -1.0 -2.0 1.2 -2.6 1.4 -2.9 -2.0 -1.1
Heart disease (siblings) 0.1 0.2 0.8 0.3 0.9 0.4 0.6 0.2 0.1 -0.3 0.4 -0.4 0.4 0.4 -0.0
Alcohol drinker status: Previous 2.5 2.9 4.4 1.2 2.1 2.0 1.6 1.1 1.9 -1.1 2.0 -1.7 1.8 2.0 1.3
Pack years of smoking 0.4 0.6 3.1 -0.3 -1.8 -0.2 0.4 0.9 -0.6 -1.0 0.1 0.8 0.0 -0.7 0.7
Impedance of whole body 1.0 5.2 14.1 3.8 2.2 0.5 -0.6 -3.5 1.2 3.0 0.8 -1.9 1.3 2.3 -3.1
Leg fat mass (left) 0.3 1.1 3.4 -1.8 -1.5 -0.6 -0.3 0.9 -1.3 -0.6 -0.7 1.3 -0.5 -1.5 0.7
Arm predicted mass (left) 0.7 3.7 9.6 -1.2 -0.1 2.0 2.6 3.1 0.8 -2.9 1.6 -1.2 0.5 0.7 3.0