Hub : Genes

BRI3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.0816 0.0304 1.3e-04 0.011 NA 0.012 NA 0.008 4.6e-02 NA 3.9e-02 NA 7.8e-02
2 GTEx Cells Transformed fibroblasts 0.2560 0.0490 6.3e-15 0.156 NA 0.249 NA 0.204 9.3e-12 NA 1.1e-18 NA 3.0e-15
3 GTEx Colon Transverse 0.1680 0.0660 5.8e-03 0.160 NA 0.067 NA 0.146 4.6e-08 NA 4.2e-04 NA 1.8e-07
4 GTEx Liver 0.3930 0.1160 2.9e-03 0.369 NA 0.288 NA 0.366 3.2e-11 NA 1.0e-08 NA 3.9e-11
5 GTEx Pancreas 0.1680 0.0710 1.4e-03 0.174 NA 0.046 NA 0.153 8.1e-08 NA 5.1e-03 NA 5.4e-07
6 GTEx Thyroid 0.1080 0.0390 5.4e-05 0.046 NA 0.056 NA 0.060 1.9e-04 NA 4.0e-05 NA 2.3e-05
7 METSIM Adipose 0.0748 0.0219 2.9e-07 0.069 0.049 0.077 0.065 0.068 1.7e-10 6.0e-08 1.1e-11 5.0e-10 2.4e-10
8 YFS Blood 0.0564 0.0157 3.7e-12 0.031 0.047 0.042 0.046 0.038 1.9e-10 2.9e-15 9.0e-14 8.9e-15 1.6e-12
9 TCGA Bladder Urothelial Carcinoma 0.1340 0.0780 1.6e-03 0.028 0.037 0.047 NA 0.045 1.9e-03 4.1e-04 7.3e-05 NA 1.0e-04
10 TCGA Breast Invasive Carcinoma 0.0646 0.0381 2.8e-04 0.025 0.019 0.017 NA 0.018 6.7e-06 7.6e-05 1.8e-04 NA 8.3e-05
11 TCGA Kidney Renal Clear Cell Carcinoma 0.0942 0.0523 2.9e-03 0.008 0.030 0.021 NA 0.026 3.6e-02 2.1e-04 1.9e-03 NA 6.3e-04
12 TCGA Liver Hepatocellular Carcinoma 0.5450 0.1490 3.6e-06 0.109 0.139 0.152 NA 0.123 8.3e-06 4.6e-07 1.2e-07 NA 2.2e-06
13 TCGA Thyroid Carcinoma 0.0400 0.0270 9.0e-05 0.053 0.046 0.040 NA 0.047 6.2e-06 2.5e-05 7.7e-05 NA 2.1e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bipolar Disorder (2018) 1.4 2.2 5.4 -2.3 -1.4 1.1 0.9 1.4 1.3 1.9 1.9 0.4 -0.1 1.2 1.2 2.3
Bipolar Disorder or Schizophrenia 0.9 2.3 5.9 -0.7 -0.7 2.0 2.0 1.8 1.6 1.2 1.8 -1.6 -0.9 0.8 2.4 0.5
Depressed Affect (Nagel 2018) 1.1 2.3 4.6 2.0 1.9 -1.3 -1.4 -1.7 -2.1 -1.7 -0.8 0.3 1.2 -0.5 -1.3 -2.0
Depression (Nagel 2018) 0.2 0.3 1.1 0.6 1.0 -0.3 -0.2 -0.2 -0.8 0.0 -0.1 0.5 1.0 0.2 -0.3 -0.4
Intelligence (Savage-Jansen 2018) 0.5 1.7 5.8 0.9 -0.2 1.6 1.6 1.6 2.4 1.1 -1.5 -0.3 -0.2 0.7 1.8 0.6
Neuroticism (Nagel 2018) 3.5 8.2 16.6 3.9 4.1 -2.4 -2.4 -2.9 -3.7 -3.0 -2.0 0.6 2.8 -0.4 -1.9 -4.1
Schizophrenia (2018) 0.9 1.8 5.5 1.0 -0.0 1.7 1.9 1.2 1.1 -0.0 0.7 -2.3 -1.1 0.1 2.1 -1.2
Schizophrenia vs Biploar Disorder 0.4 0.6 1.8 0.8 0.4 0.9 1.0 0.7 0.6 0.5 0.9 -1.3 -0.0 0.6 1.0 -0.4
Worry (Nagel 2018) 4.7 9.9 19.1 4.2 3.9 -3.1 -3.0 -3.5 -4.4 -3.4 -2.0 1.0 2.5 -0.9 -2.4 -4.1
Alzheimer’s Disease (in mother) 0.5 0.6 1.7 -0.5 0.9 -0.1 -0.2 0.0 0.1 0.6 -1.2 1.3 1.2 0.9 -0.5 0.7
Alzheimer’s Disease (in father) 0.5 0.5 1.8 -0.7 -0.2 0.7 0.4 0.6 0.5 0.9 1.1 -0.3 0.7 1.3 0.3 1.0
Alzheimer’s Disease (including proxy) 0.4 0.6 2.8 -0.4 0.4 -0.1 -0.3 -0.1 -0.0 0.4 -0.7 1.2 1.7 1.2 -0.9 0.8
Crohns Disease (2017) 0.3 0.6 3.2 -1.6 -1.8 0.1 0.2 0.2 0.6 -0.4 0.4 -0.7 -0.9 -0.2 0.2 0.3
Irritable Bowel Disease (IBD) 0.2 0.5 1.0 -0.3 0.1 -0.6 -0.6 -0.8 -0.6 -0.9 -1.0 0.0 0.7 0.0 -0.8 -1.0
Ulcerative Colitis (UC) 1.1 2.1 4.1 0.9 1.8 -1.2 -1.2 -1.5 -1.9 -1.3 -1.7 0.7 1.7 -0.1 -1.3 -2.0
Major Depression (MDD) 0.1 0.1 0.3 0.4 0.6 -0.3 -0.4 -0.4 -0.2 -0.0 0.2 0.2 0.5 0.0 -0.4 -0.4
Reaction Time 0.8 1.6 6.8 0.6 2.6 -0.1 -0.4 -0.5 -0.9 -0.4 -1.5 1.2 2.5 1.3 -0.2 -0.6
Verbal and Numeric Reasoning (VNR) 1.1 2.7 6.7 0.6 -0.3 2.2 2.2 2.1 2.6 1.8 -0.7 -0.6 0.5 1.6 2.4 1.1
Breast Cancer 1.3 3.2 13.1 -3.0 -1.5 -0.4 -0.4 0.5 0.5 1.7 0.9 3.6 0.8 0.7 -1.0 3.3
Ovarian Cancer 0.9 1.2 4.7 -1.9 -1.6 0.4 0.2 0.7 0.8 0.9 1.1 0.8 -0.7 0.3 -0.2 2.2
Prostate Cancer 16.6 23.3 41.0 -5.5 -5.1 5.0 5.0 5.7 6.4 6.2 3.4 -1.8 -1.9 2.9 4.7 6.0
Age at First Birth 0.1 0.1 0.4 0.7 0.6 -0.0 0.0 0.0 0.1 0.2 -0.4 -0.3 -0.2 -0.0 0.4 -0.0
Bipolar Disorder (2011) 0.8 0.8 1.8 -1.0 -0.9 1.0 0.9 1.0 1.4 0.4 0.5 -0.2 -0.5 0.3 1.1 1.2
Body Mass Index (BMI) (2010) 0.4 0.5 0.8 0.9 0.8 0.8 0.8 0.7 0.8 0.4 -0.8 -0.8 0.3 0.8 0.7 -0.1
Coronary Artery Disease (CAD) 0.4 0.4 2.4 0.0 1.0 -0.3 -0.2 -0.1 0.1 0.1 -0.9 1.6 1.0 0.0 0.2 -0.5
Crohns Disease (2012) 0.6 1.0 2.4 -1.2 -1.5 0.9 1.0 1.0 1.4 0.1 0.4 -1.1 -1.2 -0.2 0.9 0.3
Mean Putamen Volume 1.0 1.1 3.1 -0.2 -1.1 -0.5 -0.8 -0.9 -1.4 -0.9 1.0 -1.1 -1.8 -1.6 -0.5 -0.8
Fasting Glucose 1.9 2.2 4.1 1.0 1.8 -1.5 -1.5 -1.8 -2.0 -2.0 -1.2 -0.7 1.0 -0.4 -1.4 -2.0
HbA1C 1.3 1.5 3.1 0.2 -0.2 -1.6 -1.5 -1.6 -1.3 -1.6 0.3 -0.7 -0.9 -1.8 -1.3 -1.1
HDL Cholesterol 0.1 0.1 0.5 -0.6 -0.3 -0.1 0.0 0.2 0.2 0.2 0.6 0.2 -0.0 -0.0 -0.2 0.7
LDL Cholesterol 5.0 8.0 15.9 0.3 -0.6 -3.9 -4.0 -4.0 -3.6 -3.6 -0.1 0.9 -1.2 -3.0 -3.8 -2.3
Lupus 1.3 1.9 6.3 -1.7 -2.5 -0.3 -0.3 0.1 0.4 0.1 2.5 -0.8 -2.4 -1.1 -0.3 1.3
Neuroticism (2016) 1.3 1.8 3.8 0.6 1.3 -1.4 -1.6 -1.7 -1.9 -1.5 -1.1 1.6 1.3 -0.4 -1.1 -1.1
Primary Biliary Cirrhosis 0.3 0.4 1.3 -0.3 -0.4 0.8 0.9 0.7 0.8 0.3 0.4 -0.7 -0.6 -0.0 1.1 -0.1
Rheumatoid Arthritis 0.4 0.5 1.2 -0.2 0.3 -0.8 -0.6 -0.7 -0.9 -1.1 0.6 -0.5 -0.5 -0.9 -0.7 -0.8
Schizophrenia (2014) 1.2 2.7 5.8 -0.3 -0.1 2.2 2.3 1.9 1.8 1.1 1.9 -2.3 -1.3 0.5 2.4 -0.1
Triglycerides 0.4 0.6 1.2 0.6 -0.0 -1.1 -1.1 -1.1 -1.1 -0.8 0.0 1.1 0.4 -0.4 -0.5 -0.7
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.8 -0.2 -0.8 -0.2 -0.4 -0.3 -0.2 -0.4 0.1 -0.5 -0.9 -0.6 -0.2 0.0
Ulcerative Colitis 0.5 0.8 3.8 0.9 1.4 0.1 0.0 -0.2 -0.6 0.1 -0.7 0.0 2.0 1.3 -0.3 -0.8
Blood Eosinophil Count 0.6 4.3 19.4 2.8 2.1 -1.1 -0.9 -1.6 -1.3 -2.0 -4.4 -1.1 0.5 -1.1 -0.6 -3.3
Blood Platelet Count 0.3 3.8 8.5 1.0 -0.8 -2.3 -2.5 -2.6 -1.9 -2.9 -1.1 -0.8 -1.3 -2.3 -2.1 -1.9
Blood Red Count 0.7 6.5 24.5 -1.9 -0.8 -3.3 -3.4 -2.6 -2.7 -1.0 -0.0 5.0 -0.7 -2.7 -3.1 1.2
Blood White Count 1.2 9.1 24.6 -3.3 -4.5 2.4 2.3 2.2 2.4 1.9 2.4 -4.9 -5.0 -1.1 1.9 1.7
Heel T-Score 1.9 15.2 29.1 0.0 -0.4 5.4 5.3 5.1 5.1 4.5 0.6 -4.3 0.9 4.5 4.8 2.1
BMI 0.5 2.8 5.5 1.9 1.3 1.8 1.9 1.5 1.2 1.6 -2.4 -0.8 1.7 2.1 2.0 -0.5
Height 0.1 2.7 9.7 -1.5 -3.1 0.1 -0.1 0.3 0.8 -0.4 2.1 0.8 -3.1 -1.9 -0.6 2.0
Waist Hip Ratio (WHR) 1.3 5.9 12.0 0.3 -1.6 -2.5 -2.8 -3.0 -2.7 -3.5 -0.7 -1.3 -2.2 -3.4 -2.8 -2.2
Systolic Blood Pressure 0.4 1.8 8.4 -0.6 -0.8 1.1 0.8 1.1 0.7 1.9 2.9 -0.7 -0.2 1.1 1.0 1.9
Smoking Status 2.4 5.8 15.9 -3.5 -4.0 2.0 1.8 2.2 2.6 2.5 2.7 -0.8 -1.9 0.5 1.5 2.9
Allergy or Eczema 1.9 5.0 13.5 3.7 3.6 -1.3 -1.1 -1.8 -1.6 -1.7 -3.4 -0.4 1.6 -0.2 -0.7 -3.5
Cardiovascular Disease 0.9 2.8 6.8 2.6 0.5 -2.0 -2.1 -2.2 -2.6 -1.2 -0.9 0.2 0.7 -0.7 -1.8 -1.8
Hypothyroidism (self reported) 0.9 2.0 4.7 -0.9 -1.9 -1.2 -1.4 -1.1 -1.5 -0.9 1.6 1.2 -1.6 -1.7 -2.2 0.4
Respiratory disease 0.7 1.5 4.9 2.2 1.4 -0.8 -0.9 -1.2 -1.2 -0.9 -1.5 -0.0 1.3 0.3 -0.7 -1.6
Type 2 Diabetes (T2D) (2018) 0.9 1.6 4.1 -0.0 0.0 -1.7 -2.0 -1.9 -1.6 -1.2 -0.7 1.4 0.1 -1.1 -1.8 -0.4
Lung FEV1/FVC ratio 0.3 1.3 5.8 -0.8 -1.8 0.4 0.5 0.5 0.9 0.1 1.0 -2.4 -2.0 -0.8 0.2 0.6
Lung FVC 0.4 2.1 8.6 -1.3 -0.7 -1.4 -1.5 -1.1 -1.4 -0.5 1.9 2.9 -0.6 -1.5 -1.4 0.8
Neuroticism 1.2 2.9 8.2 2.9 2.3 -1.1 -1.1 -1.5 -2.2 -1.3 -1.1 0.4 2.1 0.2 -0.7 -2.4
Chronotype (morning person) 1.6 3.8 7.8 -2.6 -2.4 1.5 1.4 1.8 1.7 2.5 2.8 -0.6 -1.8 0.4 1.2 2.8
Hair Pigment 0.1 1.5 3.8 1.6 0.9 -1.0 -0.9 -1.1 -1.3 -1.4 -1.3 0.5 0.1 -1.2 -2.0 -1.6
Tanning 0.5 6.7 10.5 -3.2 -2.9 2.8 2.7 3.1 3.2 2.6 1.8 -1.3 -1.3 1.6 2.5 3.2
Hand grip strength (left) 1.2 3.1 7.2 -2.0 -2.4 1.4 1.3 1.7 2.0 2.1 1.9 -0.5 -1.2 0.9 1.2 2.7
Number of treatments/medications taken 0.9 1.7 4.7 1.8 1.9 -0.7 -0.6 -0.8 -1.0 -0.5 -1.9 1.3 2.2 0.8 -0.3 -1.2
Average weekly spirits intake 1.2 1.5 5.7 -0.9 -1.0 1.2 1.3 1.5 1.7 2.4 0.1 0.6 0.0 0.9 0.9 1.5
Sensitivity / hurt feelings 2.0 3.4 9.7 2.7 2.4 -1.1 -1.2 -1.8 -2.4 -2.2 -1.2 -0.4 1.2 -0.7 -1.1 -3.1
Frequency of depressed mood in last 2 weeks 0.7 0.9 4.8 0.4 1.6 -0.3 -0.3 -0.3 -0.9 0.4 0.1 1.3 2.2 0.9 -0.6 -0.3
Hearing difficulty/problems: Yes 0.2 0.4 1.3 0.5 0.4 -0.6 -0.5 -0.6 -1.1 -0.4 -0.2 -0.4 0.1 -0.3 -0.9 -0.9
Relative age of first facial hair 0.7 1.3 2.8 1.2 -0.7 -1.4 -1.4 -1.3 -1.4 -1.5 0.4 0.0 -0.8 -1.7 -1.2 -0.8
Other serious medical condition/disability diagnosed by doctor 0.3 0.3 1.1 0.8 -1.1 0.4 0.4 0.5 0.2 0.2 0.2 0.9 -0.4 -0.3 0.3 0.9
Ever used hormone-replacement therapy (HRT) 0.7 0.9 4.1 -0.3 -1.7 0.5 0.5 0.3 0.5 0.4 0.7 -1.6 -2.0 -1.0 0.4 -0.1
Ever had hysterectomy (womb removed) 0.4 0.5 1.9 0.6 -0.5 0.5 0.5 0.3 0.8 -0.3 -1.4 -1.2 -0.4 -0.0 0.7 -0.3
Systolic blood pressure, automated reading 0.7 2.0 5.0 0.4 1.0 1.6 1.5 1.6 1.4 2.2 1.2 -0.4 0.9 1.7 1.8 1.2
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 3.3 0.3 -0.4 1.4 1.4 1.2 1.1 1.1 0.7 -1.8 -0.3 0.8 1.6 -0.0
Angina 0.5 0.7 1.3 1.1 0.5 -1.0 -0.9 -1.0 -1.0 -0.9 -1.1 0.1 0.9 0.3 -0.5 -0.7
Medication for hormone replacement therapy 0.2 0.2 2.0 -0.2 -0.0 0.3 0.2 0.1 0.5 0.0 -1.4 0.1 0.2 0.2 0.2 -0.2
Vitamin and mineral supplements 5.2 7.0 13.8 3.0 0.5 -2.7 -2.7 -3.2 -3.1 -3.6 -1.8 -1.1 -1.3 -3.1 -2.3 -3.7
Supplements: Zinc 0.9 0.9 3.7 -1.9 -0.8 0.3 0.4 0.7 0.6 1.0 1.1 1.7 -0.3 -0.2 0.1 1.3
Medication: Co-codamol 1.1 1.3 4.5 -0.5 -1.2 1.3 1.5 1.3 1.2 0.7 0.1 -2.1 -1.1 -0.0 1.5 0.1
Medication: Metformin 1.6 2.3 4.4 0.5 0.8 -1.9 -2.1 -2.1 -1.7 -1.7 -1.9 1.2 0.5 -1.0 -1.8 -1.1
Diabetes (father) 0.8 1.0 2.9 -0.9 1.2 1.1 0.9 0.9 0.6 1.1 0.7 -1.1 1.1 1.7 0.6 0.5
Diabetes (mother) 1.4 1.8 3.8 0.4 0.7 -1.6 -1.6 -1.8 -1.9 -1.4 0.5 1.2 -0.0 -1.6 -1.2 -1.7
Severe depression (siblings) 0.8 0.9 3.6 1.9 0.9 -0.7 -0.7 -0.9 -1.1 -1.0 -0.6 0.8 0.2 -0.7 -0.7 -1.3
Pack years adult smoking proportion 0.3 0.4 1.0 -0.6 0.1 0.7 0.6 0.7 0.5 1.0 0.2 -0.1 0.5 1.0 0.8 0.5
Impedance of leg (right) 0.6 2.9 7.1 -2.7 -1.7 -1.7 -2.0 -1.5 -1.0 -0.6 2.1 1.9 -0.9 -1.4 -2.4 0.9
Leg fat-free mass (left) 0.4 1.9 5.2 0.7 -0.8 1.9 2.0 1.8 1.7 1.0 -0.2 -1.6 -0.8 0.6 2.3 0.5
Trunk fat percentage 0.2 0.8 3.4 1.0 0.9 -0.8 -0.7 -1.0 -0.5 -0.6 -1.3 -0.1 -0.2 -0.9 -0.7 -1.9
Hand grip strength (right) 1.0 2.8 6.4 -1.1 -2.2 1.5 1.6 1.9 2.0 2.0 1.2 -0.9 -1.4 0.8 1.4 2.5
Townsend deprivation index at recruitment 0.9 1.3 3.0 -1.7 -1.2 1.0 1.0 1.2 1.0 1.5 0.8 -0.8 -0.1 1.1 0.9 1.6
Current tobacco smoking 1.8 2.9 8.1 -2.9 -2.3 1.4 1.2 1.6 1.9 2.2 1.6 -0.6 -0.5 1.1 0.9 2.3
Average weekly fortified wine intake 0.4 0.5 1.8 1.3 0.9 0.4 0.4 0.1 0.2 -0.0 -1.3 -0.2 0.4 0.2 0.3 -1.0
Maternal smoking around birth 1.1 1.6 3.2 -0.9 -0.6 1.4 1.4 1.5 1.8 1.5 -0.6 -0.8 0.3 1.4 1.7 1.3
Fed-up feelings 0.3 0.6 3.0 0.8 1.2 -0.3 -0.5 -0.5 -0.9 -0.0 -0.5 0.6 1.7 0.8 -0.4 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 1.2 -0.0 0.7 -0.1 -0.1 -0.0 -0.5 0.3 -0.1 0.5 1.1 0.4 -0.2 -0.1
Relative age voice broke 0.6 1.0 2.3 0.6 -0.9 -1.2 -1.2 -1.1 -0.9 -1.4 0.1 0.7 -0.8 -1.5 -0.8 -0.5
Taking other prescription medications 0.2 0.2 0.8 -0.3 -0.6 0.1 0.2 0.3 -0.3 0.9 0.8 0.6 0.1 0.3 0.0 0.6
Age when periods started (menarche) 0.2 0.5 1.4 0.4 0.3 0.9 0.9 0.9 1.0 0.6 0.1 0.7 0.3 0.5 1.2 0.5
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 4.5 -0.8 -1.2 1.4 1.4 1.1 1.6 0.5 -0.5 -2.1 -1.0 0.2 1.7 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 2.3 -0.0 0.4 0.8 0.6 0.8 0.7 1.2 -0.6 1.1 1.3 1.5 0.5 1.1
Tinnitus: Yes, but not now, but have in the past 1.2 1.2 4.5 2.0 1.4 -0.5 -0.5 -0.9 -1.4 -1.1 -0.5 -0.0 0.9 -0.3 -0.1 -2.1
Qualifications: CSEs or equivalent 0.5 0.7 2.0 -0.4 -0.5 -0.7 -0.8 -0.9 -0.9 -0.2 0.0 -1.4 -0.9 -1.1 -0.9 -0.7
Serious illness, injury or assault to yourself 0.1 0.1 0.4 0.4 -0.6 0.0 0.2 0.2 0.0 0.1 0.1 -0.3 -0.2 0.0 0.1 0.1
High blood pressure 0.6 1.6 7.3 2.7 2.2 -0.6 -0.6 -0.7 -1.0 0.2 -0.8 -0.1 2.1 1.1 -0.1 -0.9
Hayfever, allergic rhinitis or eczema 1.2 2.5 5.8 2.3 1.8 -1.3 -1.2 -1.6 -1.5 -1.7 -2.4 -0.1 0.4 -0.9 -1.0 -2.4
Multivitamins +/- minerals 2.4 3.1 6.5 -2.5 -1.0 1.6 1.6 2.0 2.0 2.1 2.2 0.6 0.1 1.6 1.2 2.5
Stomach or abdominal pain in last month 0.4 0.6 1.8 0.7 0.8 0.5 0.7 0.7 -0.1 0.7 0.8 0.1 1.4 1.2 0.6 0.2
Supplements: Glucosamine 2.3 2.9 6.3 0.1 0.2 2.1 2.3 2.3 2.5 2.3 -0.3 0.0 0.6 1.9 2.5 1.4
Diverticular disease/diverticulitis (self-reported) 2.4 2.8 4.8 1.5 0.7 -1.9 -1.9 -2.1 -1.8 -2.1 -2.2 0.6 0.0 -1.7 -1.5 -2.0
Medication: Atenolol 0.5 0.7 1.4 0.4 0.9 -1.0 -1.0 -1.1 -0.6 -1.0 -1.2 0.3 0.5 -0.0 -0.9 -0.8
Medication: Levothyroxine sodium 1.3 2.3 4.2 0.1 -1.3 -1.6 -1.8 -1.8 -1.8 -1.9 0.9 0.7 -1.5 -2.0 -1.9 -1.0
Sitting height 0.6 4.4 12.8 -1.9 -3.6 1.5 1.3 1.8 2.1 1.8 2.8 0.3 -2.7 -0.4 1.0 3.0
Chronic bronchitis/emphysema (father) 0.6 0.7 2.2 -0.9 -0.4 1.2 1.1 1.0 0.9 0.7 0.8 -1.5 -0.5 0.5 0.7 0.2
High blood pressure (mother) 2.1 3.0 6.0 1.1 1.1 -2.4 -2.4 -2.3 -2.1 -1.8 -1.2 1.6 0.9 -0.9 -2.4 -0.8
Body mass index (BMI) 0.5 2.3 6.2 2.5 1.9 1.1 1.3 0.8 0.7 0.7 -2.4 -1.6 1.0 1.1 1.7 -1.4
Impedance of leg (left) 0.7 3.5 8.5 -2.9 -1.6 -2.0 -2.2 -1.7 -1.4 -0.7 2.3 1.8 -1.0 -1.6 -2.7 0.7
Leg predicted mass (left) 0.3 1.8 5.2 0.7 -0.7 1.8 1.9 1.8 1.7 0.9 -0.1 -1.5 -0.8 0.6 2.3 0.5
Trunk fat mass 0.1 0.4 1.5 1.0 0.5 -0.0 0.1 -0.2 0.2 0.0 -1.2 -0.5 -0.3 -0.4 0.2 -1.2
Waist circumference 0.3 0.9 3.4 1.3 -0.3 0.2 0.2 -0.2 -0.1 -0.7 -1.3 -1.9 -1.1 -0.9 0.4 -1.6
Number of incorrect matches in round 1.4 2.4 7.9 1.6 2.8 -0.1 -0.0 -0.4 -0.7 0.4 -2.5 -0.7 2.8 1.8 -0.5 -1.4
Past tobacco smoking 1.4 2.5 4.4 1.7 1.4 -1.9 -1.8 -1.8 -1.8 -1.3 -2.1 1.1 0.7 -1.0 -1.8 -1.4
Alcohol usually taken with meals 0.5 0.8 3.2 -0.0 -1.1 0.6 0.6 0.7 0.9 0.6 1.5 -0.6 -1.8 -0.5 0.2 0.8
Nervous feelings 5.8 10.7 19.8 4.5 3.5 -3.6 -3.6 -3.9 -4.3 -3.4 -1.7 1.2 2.3 -1.1 -3.5 -3.6
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.2 9.0 0.8 1.9 1.1 1.2 1.1 0.5 1.7 0.6 0.2 3.0 2.5 1.2 0.1
Hearing difficulty/problems with background noise 1.6 2.6 7.1 1.5 1.6 -1.5 -1.5 -1.9 -2.6 -1.5 -0.4 -0.7 1.2 -0.3 -1.7 -2.7
Hair/balding pattern: Pattern 2 0.9 1.1 3.0 0.4 -0.3 1.0 1.4 1.4 1.4 0.8 0.8 -1.7 -0.8 0.4 1.5 0.7
Had menopause 1.0 1.3 2.2 1.3 1.0 1.5 1.5 1.2 1.5 0.9 -1.0 -0.2 0.7 1.3 1.3 -0.2
Had other major operations 0.1 0.1 0.4 -0.2 -0.4 -0.3 -0.2 -0.3 -0.1 0.1 -0.7 -0.5 -0.5 -0.3 -0.3 -0.1
Forced vital capacity (FVC) 1.0 4.0 12.9 -2.6 -3.6 -1.1 -1.2 -0.5 -0.6 -0.1 2.8 2.0 -2.6 -2.2 -1.3 1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 2.0 -0.4 0.0 0.8 0.7 0.9 1.0 1.3 0.2 0.5 0.9 1.4 0.3 1.4
Ever unenthusiastic/disinterested for a whole week 1.6 2.0 3.6 1.9 1.8 -1.2 -1.2 -1.4 -1.8 -1.3 -1.5 1.2 1.4 -0.4 -0.7 -1.8
Qualifications: None of the above 0.2 0.5 1.6 -1.2 0.4 -0.6 -0.6 -0.6 -0.9 0.3 -0.8 0.5 1.1 0.5 -0.5 -0.3
Financial difficulties in last 2 years 0.7 0.9 5.5 -0.5 -0.8 0.9 0.8 1.0 0.3 0.9 2.3 0.4 0.1 0.7 0.7 1.0
Mouth/teeth dental problems 0.2 0.3 1.1 0.1 -0.0 -0.4 -0.3 -0.4 0.1 -0.4 -1.0 0.0 -0.7 -0.9 -0.2 -0.6
Heart attack 1.8 2.3 9.8 1.6 2.8 -0.0 -0.1 -0.4 -0.4 -0.3 -1.7 -0.1 3.1 2.0 -0.1 -1.3
Allergy 1.2 2.7 6.2 -2.4 -1.8 1.5 1.4 1.8 1.7 1.8 2.2 0.5 -0.5 0.7 1.1 2.5
Pain all over the body in last month 0.5 0.5 1.5 -0.8 0.5 -1.0 -0.9 -0.8 -0.9 -0.1 0.2 0.6 0.3 -0.2 -1.2 0.1
Diabetes (self-reported) 0.2 0.3 1.3 -0.0 0.3 -0.3 -0.6 -0.7 -0.3 -0.6 -1.1 0.1 0.4 -0.0 -0.4 -0.5
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 5.7 1.9 0.6 -0.0 -0.1 -0.4 0.1 -0.5 -2.4 0.3 0.6 -0.1 0.2 -1.1
Medication: Ramipril 0.3 0.4 1.4 1.0 0.6 0.4 0.2 0.2 -0.0 0.4 0.1 -0.6 1.1 1.2 0.7 -0.0
Medication: Simvastatin 0.2 0.3 1.4 0.2 0.3 -0.1 -0.3 -0.6 -0.5 -0.6 -0.4 -1.0 -0.2 -0.4 -0.2 -1.2
Fluid intelligence score 0.4 0.8 3.0 -0.0 -1.2 0.9 0.9 0.9 1.7 0.5 -0.4 -0.5 -0.9 -0.0 1.0 0.7
Illnesses of siblings 0.4 0.6 2.1 1.1 0.2 -0.6 -0.5 -0.6 -0.5 -1.5 -1.1 0.5 0.2 -0.6 -0.4 -0.9
Neuroticism score 1.4 2.9 7.7 2.8 2.7 -1.0 -1.0 -1.4 -2.1 -1.2 -1.1 -0.1 2.3 0.5 -0.8 -2.3
Weight 0.2 0.8 2.1 0.9 -0.3 1.1 1.2 1.0 1.0 0.7 -0.6 -1.4 -0.7 0.1 1.4 -0.3
Impedance of arm (right) 1.8 8.6 16.9 -2.4 -1.8 -3.6 -3.8 -3.4 -3.1 -2.7 1.8 3.0 -2.0 -3.7 -4.1 -0.4
Arm fat percentage (right) 0.4 1.7 5.6 2.4 1.9 -0.7 -0.4 -0.9 -0.8 -0.7 -2.3 -0.0 0.7 -0.4 -0.1 -2.2
Trunk fat-free mass 0.7 4.2 9.5 -0.0 -1.3 2.8 2.8 2.8 2.7 1.9 0.5 -1.9 -0.9 1.4 3.1 1.6
Hip circumference 0.2 0.7 1.6 0.6 -0.5 1.0 1.2 1.0 1.1 1.1 0.0 -0.9 -0.6 0.2 1.3 -0.0
Time employed in main current job 1.4 1.6 2.9 0.3 -1.6 -1.5 -1.6 -1.5 -0.7 -1.7 0.6 0.3 -1.3 -1.7 -1.7 -0.1
Alcohol intake versus 10 years previously 0.5 0.8 3.3 -0.9 -0.5 -0.9 -1.0 -0.6 -0.8 -0.3 1.8 1.0 0.3 0.1 -0.8 1.1
Father’s age at death 0.4 0.6 2.0 -0.1 -0.5 -0.9 -0.8 -0.6 -0.7 -0.3 1.1 1.4 0.3 -0.6 -1.1 0.3
Worrier / anxious feelings 1.8 3.5 7.4 2.7 2.4 -1.4 -1.6 -1.9 -2.7 -2.0 -0.7 0.6 1.9 0.0 -1.5 -2.4
Frequency of tiredness / lethargy in last 2 weeks 2.0 3.2 10.0 3.2 2.6 -1.2 -1.2 -1.4 -2.2 -0.8 -1.0 0.8 2.8 0.6 -0.9 -2.0
Falls in the last year 3.0 4.1 7.4 -0.7 -0.6 2.6 2.6 2.7 2.6 2.4 -0.8 -0.2 1.0 2.7 2.4 2.3
Hair/balding pattern: Pattern 3 2.1 3.2 7.4 2.3 2.7 -1.1 -1.2 -1.7 -1.7 -1.2 -2.6 1.2 2.0 -0.0 -0.9 -2.5
Number of live births 0.3 0.5 1.8 0.0 -0.1 -0.0 -0.1 -0.4 -0.7 -0.8 0.1 -1.4 -0.8 -0.7 -0.1 -1.3
Forced expiratory volume in 1-second (FEV1) 1.0 3.4 10.2 -2.2 -3.2 -1.2 -1.2 -0.7 -0.7 -0.6 2.5 1.0 -2.8 -2.6 -1.3 1.2
Pulse rate 1.0 1.7 5.9 -2.4 -1.7 0.8 0.9 0.8 0.9 0.8 1.0 -1.6 -2.2 -0.8 0.6 0.2
Happiness 0.7 0.8 2.4 0.5 0.7 -0.8 -1.0 -1.0 -1.3 -1.5 -0.7 0.7 0.1 -0.7 -1.0 -0.9
Noisy workplace 1.1 1.3 5.7 1.4 1.3 -0.2 0.2 -0.4 -0.5 -0.8 -2.2 -0.8 -0.2 -0.9 0.3 -2.4
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.4 1.0 -0.8 0.3 0.2 0.2 0.3 -0.3 1.2 -0.7 -0.8 -0.1 -0.1 0.3
Serious illness, injury or assault of a close relative in last 2 years 2.4 2.7 4.0 1.8 1.7 -1.6 -1.9 -2.0 -2.0 -1.4 -1.8 -0.5 1.7 0.4 -1.8 -1.7
Mouth/teeth dental problems: Dentures 1.6 2.6 6.2 1.0 0.9 1.9 1.9 1.9 1.4 2.0 -0.3 -0.4 1.9 2.5 2.2 0.7
Asthma 0.5 1.0 5.9 2.4 1.1 -0.2 -0.1 -0.5 -0.6 -0.6 -1.2 -0.4 0.5 -0.1 -0.1 -1.6
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 2.0 -1.1 0.5 -0.4 -0.5 -0.2 0.2 0.3 -0.6 1.4 1.4 1.0 -0.3 0.8
Medication: Cholesterol lowering 0.9 1.4 5.5 1.0 2.3 -0.8 -1.0 -1.0 -1.1 -0.2 -0.9 0.8 2.2 0.9 -0.8 -0.7
Depression (self-reported) 1.4 1.7 4.5 0.5 2.1 -1.1 -1.0 -1.4 -1.6 -1.1 -1.3 0.3 1.1 -0.5 -1.2 -2.1
Medication: Lansoprazole 0.3 0.4 0.8 -0.7 0.4 0.7 0.9 0.9 0.7 0.8 -0.2 -0.2 0.3 0.8 0.5 0.2
Prospective memory result 1.3 1.6 7.6 1.7 2.8 0.5 0.8 0.3 -0.4 0.2 -0.1 -0.9 2.0 1.4 1.0 -1.3
Lung cancer (father) 0.6 0.6 4.2 -0.1 0.6 0.8 0.7 0.5 0.6 0.3 -2.0 -1.2 -0.1 0.1 0.6 -0.4
Illnesses of mother 1.8 2.2 5.1 -1.0 -0.5 1.8 1.9 1.9 1.7 1.7 1.6 -1.0 -0.2 1.1 2.2 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.8 11.6 -2.2 -3.4 -0.4 -0.4 -0.0 -0.2 0.1 2.1 -0.0 -2.9 -1.9 -0.5 1.6
Pulse wave Arterial Stiffness index 0.5 0.6 2.1 -0.2 -0.1 0.6 0.9 0.9 1.0 1.4 -0.1 -1.0 0.1 0.7 0.6 0.6
Impedance of arm (left) 2.3 10.5 21.0 -2.9 -2.3 -3.9 -4.0 -3.6 -3.1 -3.0 2.1 2.9 -2.6 -4.3 -4.6 -0.5
Arm fat mass (right) 0.3 1.0 4.2 1.9 1.2 0.4 0.5 0.1 0.3 0.1 -2.0 -0.8 0.5 0.2 0.9 -1.4
Trunk predicted mass 0.8 4.6 10.3 -0.1 -1.4 3.0 2.9 2.9 2.9 2.0 0.6 -1.9 -0.9 1.5 3.2 1.7
Standing height 0.5 5.4 21.1 -3.2 -4.6 0.4 0.1 0.6 0.9 0.2 3.7 0.1 -3.7 -1.7 -0.2 2.5
Length of working week for main job 1.5 1.6 4.7 -1.7 -2.2 0.9 0.9 1.0 1.4 -0.2 0.4 -1.6 -2.0 -0.6 0.8 0.9
Exposure to tobacco smoke at home 4.1 4.6 8.9 3.0 2.1 -2.2 -2.0 -2.5 -2.9 -2.1 -2.0 -0.2 1.7 -0.5 -1.9 -2.9
Breastfed as a baby 1.9 2.3 6.7 0.8 0.1 0.9 0.5 1.0 1.1 1.4 -0.1 2.6 2.4 2.5 0.9 2.1
Tense / ‘highly strung’ 2.5 4.1 14.4 3.7 3.8 -0.2 -0.0 -0.6 -1.3 -0.8 -2.3 -0.4 2.8 1.2 0.6 -2.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.6 4.0 1.6 1.8 -1.1 -0.9 -1.0 -1.4 -0.4 0.7 2.0 1.9 0.2 -0.8 -1.0
Hair/balding pattern: Pattern 4 0.2 0.5 0.9 -0.8 0.6 -0.8 -0.8 -0.8 -0.9 -0.6 0.5 -0.2 -0.1 -0.6 -1.0 -0.5
Birth weight of first child 0.4 0.8 2.2 1.3 1.2 -1.1 -0.8 -0.8 -1.1 -0.4 -0.1 0.2 0.2 -0.6 -1.5 -0.7
Peak expiratory flow (PEF) 0.4 0.9 4.0 -0.6 -2.0 0.2 0.3 0.4 0.3 0.1 0.8 -0.3 -2.0 -1.4 0.2 0.7
Pulse wave reflection index 1.0 1.2 3.1 -0.7 -0.9 0.9 0.9 1.2 1.0 1.7 1.4 -0.7 0.1 1.2 0.6 1.8
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.5 0.3 0.6 0.7 0.8 0.5 0.4 0.2 -1.1 -0.4 0.3 0.1 1.2 -0.7
Loud music exposure frequency 0.7 0.8 3.3 -0.3 1.8 0.4 0.6 0.3 -0.1 0.0 -1.1 -0.0 1.5 1.1 0.8 -1.0
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.8 0.7 -0.5 0.7 0.6 0.5 0.6 0.1 0.9 -0.8 -0.4 0.1 0.2 0.2
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.2 0.4 0.3 -1.1 -1.1 -1.2 -1.5 -1.5 0.5 -0.2 -0.1 -0.9 -1.2 -1.3
Blood clot in the leg (DVT) 1.3 1.7 3.6 1.9 1.1 -1.0 -1.0 -1.3 -1.1 -1.6 -1.9 -1.3 -0.4 -0.8 -1.2 -1.7
Medication: Paracetamol 0.2 0.3 1.6 -0.0 0.3 -0.3 -0.1 -0.1 -0.6 -0.5 1.1 0.2 1.2 0.8 -0.4 -0.1
Headache pain in last month 0.3 0.5 2.9 0.9 1.1 0.3 0.4 0.3 -0.0 0.0 -0.1 0.3 1.7 1.0 0.4 -0.6
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 6.6 -1.5 -2.6 0.3 0.4 0.5 0.7 -0.4 1.5 -0.1 -2.6 -1.5 0.2 0.8
Glaucoma (self-reported) 0.5 0.6 3.3 0.1 1.5 0.1 0.2 0.4 0.1 0.8 -0.5 1.8 1.0 0.6 0.2 0.7
Gout (self-reported) 1.7 2.4 4.6 1.9 1.8 -1.5 -1.7 -1.7 -1.9 -1.2 -2.1 0.8 1.4 -0.3 -1.1 -1.4
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 3.5 0.2 -0.6 -1.2 -1.4 -1.3 -1.5 -1.2 0.7 1.6 -0.5 -1.1 -1.9 -0.2
Medication: Amlodipine 1.8 2.5 11.0 1.7 3.3 0.8 0.7 0.6 0.2 0.9 -1.3 0.4 2.9 2.1 0.9 -0.5
Medication: Ventolin 100micrograms inhaler 0.8 1.0 3.9 2.0 1.2 0.8 0.9 0.7 0.6 0.6 -0.7 -0.4 0.8 1.1 1.4 -0.5
Birth weight 0.2 0.4 1.7 0.5 -0.7 0.5 0.4 0.6 0.5 0.9 0.4 1.3 -0.3 -0.1 0.1 1.0
Chronic bronchitis/emphysema (mother) 0.5 0.6 3.6 0.1 1.1 -0.1 -0.1 -0.5 -0.2 -0.6 -1.9 0.2 0.4 -0.5 0.0 -1.5
High blood pressure (siblings) 0.7 1.1 3.4 -0.8 -0.6 0.8 0.8 1.1 0.8 1.7 1.8 -0.1 0.2 0.9 0.6 1.5
Forced vital capacity (FVC), Best measure 0.8 2.9 12.0 -2.4 -3.5 -0.6 -0.7 -0.2 -0.4 0.1 2.2 0.8 -2.7 -1.8 -0.7 1.8
Body fat percentage 0.3 1.1 3.7 1.7 1.4 -0.7 -0.5 -0.9 -0.5 -0.5 -1.8 -0.1 0.4 -0.5 -0.3 -1.9
Leg fat percentage (right) 0.4 1.5 5.3 2.3 2.1 0.3 0.5 0.1 0.3 0.5 -1.9 -0.3 1.5 0.8 0.9 -1.4
Arm fat-free mass (right) 1.0 5.0 10.9 -0.1 -0.9 3.1 3.2 3.0 3.0 2.1 0.1 -2.4 -0.7 1.7 3.3 1.3
Exposure to tobacco smoke outside home 1.5 2.0 4.5 -1.5 -0.8 -1.7 -2.0 -1.7 -1.8 -0.6 0.5 1.7 -0.4 -1.3 -2.1 0.0
Comparative body size at age 10 0.5 1.3 2.7 -0.6 -1.6 -1.5 -1.3 -1.0 -1.0 -0.3 1.1 0.9 -1.1 -1.5 -1.5 0.5
Number of full brothers 1.3 1.6 4.0 0.7 0.0 -1.8 -1.7 -1.6 -1.5 -1.4 0.4 -0.3 -0.7 -1.3 -2.0 -0.8
Worry too long after embarrassment 1.1 1.8 6.5 2.2 2.6 -0.3 -0.4 -0.9 -1.0 -0.5 -0.9 -0.4 2.0 0.8 -0.1 -2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 2.2 -0.9 0.1 0.3 0.4 0.6 0.2 1.5 1.3 0.5 0.7 0.8 0.8 1.0
Wheeze or whistling in the chest in last year 1.3 2.4 6.1 2.5 2.3 -1.0 -0.9 -1.2 -1.8 -0.9 -1.7 0.1 2.1 0.5 -0.6 -2.2
Number of children fathered 3.4 3.8 7.7 0.1 -0.5 2.4 2.4 2.5 2.3 2.5 1.0 -0.9 1.3 2.8 2.1 2.0
Reason for reducing amount of alcohol drunk: Health precaution 3.1 3.6 7.2 1.7 1.7 2.7 2.6 2.4 2.0 1.4 -0.6 0.0 1.7 2.5 2.5 0.5
Age at first live birth 0.2 0.4 0.8 -0.2 -0.3 0.4 0.4 0.6 0.8 -0.4 0.4 0.9 -0.8 -0.4 0.9 0.9
Pulse wave peak to peak time 0.5 0.6 2.2 -0.1 -0.0 -0.7 -1.0 -1.0 -1.0 -1.5 0.3 1.1 -0.2 -0.8 -0.7 -0.5
Health satisfaction 0.2 0.3 1.2 0.5 1.1 0.1 0.2 0.1 -0.2 0.2 -0.6 0.4 1.1 0.5 0.1 -0.5
Shortness of breath walking on level ground 0.9 1.1 4.3 2.1 1.8 -0.3 -0.2 -0.6 -0.5 -0.6 -1.0 -0.5 1.2 0.3 -0.3 -1.8
Qualifications: College or University degree 0.3 1.0 1.8 1.0 -0.8 1.0 1.1 1.2 1.2 0.5 0.3 -1.3 -1.2 -0.1 1.3 0.9
Eye problems/disorders: None of the above 0.7 0.8 1.5 0.3 -0.0 -1.2 -1.1 -1.1 -1.0 -0.8 -1.2 1.2 -0.0 -0.9 -0.9 -0.7
Mouth/teeth dental problems: Loose teeth 1.2 1.4 5.6 -2.4 -0.7 1.2 0.8 1.1 1.4 1.0 0.8 -0.2 -0.1 1.2 0.1 2.0
Emphysema/chronic bronchitis 1.3 1.4 3.5 -1.1 -0.5 1.3 1.2 1.3 1.4 1.2 0.5 -0.4 1.1 1.9 1.7 1.0
Medication for pain relief, constipation, heartburn 0.6 0.9 5.1 -0.8 -1.7 0.1 0.2 0.3 0.5 0.4 0.4 -0.3 -2.3 -1.5 0.1 0.8
Neck or shoulder pain in last month 0.5 0.8 3.5 0.5 1.2 0.5 0.6 0.4 0.2 0.2 -1.1 -0.2 1.9 1.5 0.4 -0.3
Medication: Blood pressure 1.2 2.2 10.0 1.7 2.6 -0.0 -0.1 -0.1 -0.5 1.0 -1.4 0.3 3.2 2.3 -0.0 -0.3
Angina (self-reported) 0.2 0.3 1.0 0.7 0.1 -0.5 -0.4 -0.4 -0.4 -0.2 -0.8 0.1 1.0 0.7 -0.0 -0.1
Migraine (self-reported) 2.9 3.6 6.4 0.8 0.6 -2.3 -2.4 -2.5 -2.4 -2.4 -1.3 1.6 -0.0 -1.9 -2.3 -1.8
Medication: Ibuprofen 0.5 0.5 2.7 -1.6 -0.1 -0.2 -0.2 0.1 0.4 0.5 -0.5 1.1 0.8 0.7 -0.1 1.1
Medication: Allopurinol 1.3 1.8 6.1 2.5 1.6 -0.8 -1.0 -1.1 -1.4 -0.8 -2.2 -0.1 1.4 0.3 -0.7 -1.1
Medication: Omeprazole 0.2 0.3 0.8 -0.1 0.3 -0.4 -0.5 -0.6 -0.8 -0.9 0.1 -0.0 0.1 -0.1 -0.8 -0.5
Medication: Seretide 50 evohaler 0.5 0.6 2.3 1.2 0.4 0.6 0.5 0.4 0.5 0.4 -1.2 -0.6 0.4 0.5 1.5 -0.2
Mean time to correctly identify matches 1.2 2.3 9.6 1.2 3.1 -0.2 -0.4 -0.7 -0.8 -0.5 -2.5 1.1 2.4 1.0 0.0 -1.5
Heart disease (mother) 0.5 0.6 1.3 0.9 -1.1 -0.9 -1.0 -0.8 -0.7 -1.0 -0.1 0.3 -0.5 -0.7 -1.0 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 5.0 1.7 2.2 -0.5 -0.4 -0.5 -0.8 -0.2 -1.6 1.1 1.6 0.3 -0.1 -1.0
Whole body fat mass 0.1 0.6 2.2 1.5 0.8 0.1 0.3 -0.0 0.2 0.2 -1.4 -0.8 0.1 -0.0 0.5 -1.3
Leg fat mass (right) 0.3 1.0 3.5 1.9 1.2 0.6 0.8 0.5 0.5 0.6 -1.5 -0.5 1.0 0.9 1.2 -0.9
Arm predicted mass (right) 1.0 4.9 10.6 0.2 -0.9 3.1 3.1 3.0 3.0 2.1 -0.1 -2.2 -0.6 1.8 3.3 1.4
Pulse rate, automated reading 1.7 5.4 21.2 -3.0 -3.7 -1.4 -1.6 -1.4 -0.9 -1.1 1.2 -0.8 -4.6 -3.7 -1.5 0.1
Alcohol intake frequency. 0.6 1.4 4.3 -0.4 0.1 -1.5 -1.5 -1.3 -1.9 -0.9 0.1 1.0 -0.3 -1.2 -2.1 -0.1
Comparative height size at age 10 0.7 3.6 9.1 -2.5 -3.0 1.7 1.2 1.7 2.0 1.7 2.2 -0.4 -1.4 0.8 1.0 3.0
Number of full sisters 0.6 0.8 2.8 -1.7 -1.5 -0.6 -0.7 -0.5 -0.8 -0.4 1.0 0.3 -0.9 -0.9 -0.8 0.4
Suffer from ‘nerves’ 6.6 10.3 24.7 3.5 2.6 -3.4 -3.2 -3.9 -4.3 -4.0 -2.4 -0.4 0.9 -2.3 -2.5 -5.0
Overall health rating 1.4 2.9 6.4 1.4 1.7 -2.0 -2.0 -1.9 -2.5 -1.4 -1.3 1.4 2.3 0.2 -1.8 -1.2
Chest pain or discomfort 0.2 0.2 1.1 0.2 0.5 0.2 0.1 0.2 -0.4 0.3 -0.4 1.1 0.9 0.7 -0.0 0.1
Had major operations 0.3 0.3 1.7 0.1 -0.4 0.1 0.3 0.1 0.1 -0.4 -1.3 -1.1 -0.2 -0.1 0.6 -0.5
Age at last live birth 0.3 0.4 1.3 -0.1 -0.2 0.5 0.5 0.6 0.8 0.0 -0.6 0.9 -0.3 0.1 1.1 0.9
Family relationship satisfaction 0.8 1.0 2.6 -0.7 -1.3 -0.8 -1.0 -1.0 -0.9 -1.2 0.6 -0.7 -1.6 -1.4 -0.7 -0.2
Leg pain on walking 1.1 1.4 2.8 0.4 0.7 1.6 1.7 1.6 1.2 1.5 0.2 -1.1 0.4 1.4 1.3 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.6 0.2 -0.4 0.4 0.2 0.2 -0.4 0.5 0.9 -1.3 0.2 0.7 0.4 -0.0
Commuting to job workplace: Car/motor vehicle 0.6 0.7 3.1 0.7 1.0 0.4 0.4 0.3 0.5 0.2 -1.1 1.0 1.8 1.1 0.7 -0.2
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.3 -0.2 0.5 0.1 0.1 -0.0 0.4 -0.4 -0.1 -0.5 -0.4 -0.4 0.2 -0.4
Medication: Aspirin 0.8 1.1 4.5 1.2 1.5 0.4 0.3 0.3 0.3 0.7 -0.7 0.7 2.1 1.8 0.6 0.2
Supplements: Vitamin C 2.7 3.2 6.5 -0.7 0.3 2.2 2.2 2.3 2.4 2.5 0.0 -0.0 1.3 2.4 2.0 1.5
Knee pain experienced in last month 1.8 2.8 6.3 -0.4 0.3 2.1 2.2 2.0 2.0 1.6 0.3 -2.3 1.2 2.5 1.8 0.6
Hypertension (Self-reported) 0.5 1.4 8.1 2.8 1.8 -0.6 -0.6 -0.7 -1.1 -0.1 -0.6 -0.2 1.5 0.7 -0.1 -1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 3.8 0.1 -0.3 -0.0 -0.0 -0.4 -0.3 -1.3 -0.8 -1.9 -1.5 -1.0 0.1 -1.3
Illnesses of father: Heart disease 2.8 3.8 10.5 -0.3 -1.7 -2.0 -2.0 -1.9 -2.0 -2.1 1.2 0.4 -2.9 -3.2 -2.4 -0.8
Illnesses of siblings: Diabetes 0.3 0.4 2.0 0.2 1.4 -0.6 -0.5 -0.6 -0.8 0.3 -0.5 0.3 0.8 0.1 -0.3 -0.6
Smoking status: Previous 1.1 1.7 3.2 -1.1 -0.9 1.7 1.7 1.7 1.7 1.2 1.4 -0.4 -0.4 0.9 1.8 1.1
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.2 10.2 -1.6 -3.2 -0.8 -0.8 -0.6 -0.6 -0.8 1.8 -0.1 -2.4 -2.0 -0.8 0.5
Whole body fat-free mass 0.7 3.9 9.2 0.3 -1.0 2.7 2.8 2.7 2.6 1.7 0.2 -2.0 -0.9 1.3 3.0 1.2
Leg fat-free mass (right) 0.3 1.5 4.2 0.7 -0.6 1.7 1.8 1.6 1.4 0.8 -0.1 -1.5 -0.8 0.5 2.0 0.4
Arm fat percentage (left) 0.4 1.6 5.2 2.1 1.7 -0.7 -0.5 -0.9 -0.7 -0.8 -2.3 -0.1 0.5 -0.6 -0.2 -2.2
Average weekly red wine intake 1.7 2.4 6.5 -0.9 -2.5 1.6 1.6 1.6 1.4 1.4 2.3 -0.4 -2.1 -0.5 1.4 0.9
Handedness (chirality/laterality): Left-handed 1.2 1.4 4.1 -0.8 0.3 -0.4 -0.6 -0.1 -0.5 1.6 1.5 1.8 2.0 1.5 -0.7 1.4
Mood swings 1.0 1.9 5.9 1.1 2.4 -1.0 -1.1 -1.4 -1.8 -0.9 -0.3 0.4 2.1 0.6 -1.0 -1.7
Loneliness, isolation 0.1 0.2 0.5 0.5 0.1 -0.2 -0.2 -0.3 -0.6 -0.7 0.0 -0.5 -0.2 -0.4 -0.1 -0.5
Long-standing illness, disability or infirmity 0.3 0.4 1.3 0.4 0.8 -0.6 -0.8 -0.6 -0.9 -0.2 -0.2 0.8 1.2 0.3 -0.4 0.0
Ever had bowel cancer screening 2.1 2.5 6.4 1.3 1.5 -1.9 -1.9 -1.7 -1.7 -1.4 -1.0 2.5 1.4 -0.6 -1.8 -0.8
Diabetes diagnosed by doctor 0.4 0.7 2.1 0.1 0.9 -0.6 -1.1 -1.1 -0.8 -0.9 -1.4 0.2 0.8 -0.1 -0.7 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 2.3 2.5 5.3 -0.5 -1.2 -2.0 -2.0 -1.9 -1.7 -2.0 -0.1 -0.0 -2.0 -2.3 -1.7 -0.7
Friendships satisfaction 0.3 0.4 1.3 1.1 0.2 -0.5 -0.7 -0.6 -1.0 -0.9 0.2 0.0 0.0 -0.1 -0.6 -0.3
Qualifications: nursing, teaching 0.6 0.9 3.2 1.8 -0.4 -0.9 -0.8 -0.9 -1.1 -1.4 -0.2 0.4 -0.3 -1.0 -0.9 -0.8
Commuting to job workplace: Walk 1.9 2.1 3.4 -0.5 -1.9 1.7 1.6 1.6 1.4 1.5 1.7 -1.5 -1.5 0.4 1.3 1.3
Eye problems/disorders: Cataract 1.2 1.4 3.3 -0.2 -0.5 1.8 1.6 1.5 1.6 0.8 1.4 -0.8 0.1 1.3 1.3 0.9
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.5 0.4 0.3 -0.7 -0.5 -0.6 -1.0 -0.9 0.4 -0.6 -0.8 -1.2 -0.5 -0.8
Medication for cholesterol 0.5 0.8 2.7 -1.3 -0.3 0.5 0.4 0.8 0.4 1.0 1.4 1.0 0.4 0.7 0.0 1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.7 -0.0 0.6 0.9 1.0 0.8 0.6 0.8 -0.1 -0.9 1.0 1.3 1.0 0.0
Back pain experienced in last month 1.5 2.2 4.0 -0.5 -0.3 1.5 1.5 1.8 1.4 1.8 1.2 1.3 1.3 1.9 1.5 2.0
Mineral and other dietary supplements 1.9 2.6 5.7 0.6 0.4 -2.1 -2.2 -2.2 -2.0 -2.4 -0.7 0.1 -0.3 -1.6 -2.1 -1.4
Breast cancer (self-reported) 0.3 0.3 2.5 -0.5 0.9 0.1 0.1 0.0 0.3 0.0 -1.6 -0.0 0.1 -0.1 -0.2 -0.3
Asthma (self-reported) 0.6 1.3 6.0 2.4 1.3 -0.4 -0.4 -0.8 -0.9 -0.9 -1.4 -0.5 0.5 -0.3 -0.2 -1.9
Osteoporosis (self-reported) 0.7 0.9 3.4 0.6 1.3 -0.6 -0.5 -0.6 -0.3 -0.6 -1.3 1.3 1.9 0.5 -0.3 -0.9
Osteoarthritis (self-reported) 1.2 1.5 3.9 0.7 0.9 1.0 1.1 1.3 1.5 1.8 -0.8 0.3 1.7 2.0 0.9 1.2
Medication: Aspirin 0.9 1.2 4.7 1.4 1.7 0.3 0.1 0.1 0.3 0.6 -1.1 0.7 2.2 1.7 0.5 0.1
Medication: Gliclazide 1.0 1.1 2.9 0.8 0.6 -0.8 -0.8 -1.1 -0.9 -1.6 -1.7 -0.1 -0.5 -1.4 -0.1 -1.5
Illnesses of father: None of the above (group 1) 1.0 1.2 2.2 -0.2 0.5 0.9 0.9 1.0 1.2 1.1 -1.4 0.9 1.5 1.4 1.4 0.9
Smoking status: Current 1.7 2.7 7.0 -2.6 -2.1 1.5 1.3 1.6 1.8 2.2 1.5 -0.7 -0.5 1.1 1.0 2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.1 0.7 -0.3 0.1 -0.1 0.0 0.2 -0.2 0.8 0.4 0.1 0.0 0.1 -0.3 0.5
Whole body water mass 0.7 3.9 9.2 0.3 -1.1 2.7 2.8 2.7 2.6 1.7 0.2 -2.0 -0.9 1.3 3.0 1.3
Leg predicted mass (right) 0.3 1.6 4.2 0.6 -0.7 1.7 1.8 1.6 1.5 0.8 -0.0 -1.5 -0.9 0.5 2.0 0.4
Arm fat mass (left) 0.2 0.9 3.6 1.7 1.0 0.4 0.6 0.2 0.4 0.2 -1.9 -0.9 0.3 0.1 0.9 -1.4
Number of self-reported non-cancer illnesses 1.8 3.2 6.8 2.6 1.9 -1.5 -1.5 -1.9 -2.1 -1.9 -2.3 0.6 1.5 -0.3 -1.1 -2.5
Average weekly champagne plus white wine intake 0.1 0.1 1.1 1.0 0.5 -0.0 -0.3 -0.2 -0.1 -0.2 -0.3 0.3 0.2 0.2 -0.1 0.0
Miserableness 1.7 3.0 7.0 1.1 1.8 -1.8 -1.9 -2.2 -2.6 -1.9 -0.5 0.2 0.6 -1.1 -2.1 -2.4
Guilty feelings 0.2 0.3 0.7 -0.5 -0.4 0.4 0.5 0.5 0.0 0.8 0.7 -0.9 0.3 0.6 0.5 0.5
Wears glasses or contact lenses 0.6 0.6 3.4 1.8 1.2 0.3 0.6 0.2 -0.1 0.1 -0.9 -0.6 0.6 0.4 0.4 -1.0
Ever taken oral contraceptive pill 1.4 1.6 5.9 -2.4 -1.4 0.8 0.8 1.1 1.1 1.2 1.7 0.0 -0.5 0.6 0.7 1.8
Hearing aid user 2.2 2.5 5.8 1.1 1.3 -1.6 -1.7 -1.9 -1.5 -2.1 -2.2 -0.2 0.2 -1.0 -2.4 -1.6
Mother’s age at death 0.7 0.8 2.7 0.9 1.7 -0.7 -0.5 -0.7 -0.3 -0.9 -0.9 1.6 0.5 -0.6 -0.6 -0.9
Financial situation satisfaction 0.5 0.6 1.3 0.7 1.1 -0.7 -0.6 -0.7 -1.0 -1.0 -0.8 0.1 0.6 0.1 -0.7 -0.9
Tinnitus: Yes, now most or all of the time 2.5 2.9 5.4 2.2 1.1 -1.8 -1.7 -2.0 -1.5 -2.3 -1.6 1.3 -0.0 -1.7 -1.5 -2.1
Commuting to job workplace: Public transport 0.9 1.1 4.2 -1.0 -1.3 0.5 0.4 0.9 0.8 1.1 2.0 0.6 -0.6 0.3 0.2 2.0
Eye problems/disorders: Glaucoma 0.4 0.5 2.6 -0.0 1.6 -0.2 -0.3 -0.2 -0.4 0.1 -0.5 1.5 1.1 0.4 -0.4 -0.0
Medication: Blood pressure 0.3 0.5 1.8 1.3 -0.1 -0.8 -0.7 -0.7 -0.6 -0.8 -0.6 -0.4 -0.8 -0.9 -0.0 -0.8
Pain type(s) experienced in last month: Hip pain 5.3 6.7 13.8 -0.4 0.2 3.5 3.6 3.4 3.1 3.0 0.4 -1.9 1.3 3.2 3.7 1.3
Supplements: Fish oil (including cod liver oil) 1.1 1.4 3.2 -0.3 -0.1 1.7 1.7 1.6 1.5 1.6 0.3 -0.2 0.4 1.1 1.8 0.6
High cholesterol (Self-reported) 1.9 3.3 7.2 0.7 0.6 -2.5 -2.7 -2.5 -2.7 -1.9 0.1 1.5 0.2 -1.5 -2.5 -1.1
Medication: Bendroflumethiazide 0.6 0.9 2.4 1.3 1.6 -0.5 -0.4 -0.5 -1.0 0.3 -1.5 -0.7 1.3 0.9 0.2 -0.6
Medication: Paracetamol 0.4 0.6 1.3 -0.0 0.2 -0.8 -0.7 -0.6 -1.0 -0.9 1.2 0.7 1.2 0.4 -0.9 -0.2
Medication: Lisinopril 1.1 1.5 5.8 1.3 2.4 -0.8 -0.7 -0.7 -0.8 -0.1 -1.6 1.7 1.8 0.6 -0.6 -0.5
Medication: Atorvastatin 1.1 1.3 3.9 1.5 1.6 -0.7 -0.9 -0.6 -0.5 0.0 -1.6 2.0 1.8 0.9 -0.5 0.4
Illnesses of father: High blood pressure 0.4 0.5 2.0 1.4 0.5 -0.7 -0.5 -0.4 -0.8 0.1 1.4 0.6 0.8 0.1 -0.2 -0.2
Alcohol drinker status: Never 0.1 0.1 0.7 -0.1 -0.1 0.1 0.1 0.1 -0.3 0.3 0.9 -0.0 0.1 0.2 -0.4 0.1
Ever smoked 0.8 1.3 6.2 -1.6 -1.8 0.7 0.7 0.8 0.6 0.5 2.5 -0.9 -1.1 0.0 0.4 1.0
Basal metabolic rate 0.5 2.9 7.0 0.4 -1.0 2.3 2.4 2.2 2.2 1.5 0.1 -1.9 -0.9 1.0 2.6 0.9
Leg fat percentage (left) 0.4 1.4 4.7 2.2 2.1 0.2 0.4 0.0 0.1 0.5 -1.8 -0.7 1.2 0.6 0.8 -1.6
Arm fat-free mass (left) 0.9 4.6 10.4 0.3 -0.7 3.0 3.0 2.9 2.9 2.1 0.1 -2.1 -0.4 1.9 3.2 1.3
Number of operations (self-reported) 0.6 0.8 3.9 -0.4 -2.0 -0.8 -0.6 -0.5 -0.5 -0.5 -0.8 -0.4 -1.6 -1.2 -0.6 0.1
Average weekly beer plus cider intake 2.7 3.9 9.4 -0.4 0.4 -3.0 -3.1 -2.8 -2.5 -1.9 0.1 2.2 0.9 -1.4 -2.5 -0.9
Irritability 0.5 0.8 3.2 1.0 1.8 -0.3 -0.2 -0.3 -0.6 0.0 -1.0 0.3 1.7 0.9 0.0 -0.7
Risk taking 2.7 4.0 7.7 -1.7 -1.3 2.6 2.6 2.6 2.7 2.3 0.8 -1.1 -0.3 1.5 2.8 1.6
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.6 -1.1 -0.5 0.6 0.6 0.8 0.8 0.9 1.2 0.6 0.1 0.8 0.3 1.2
Fractured/broken bones in last 5 years 0.3 0.3 1.0 -0.6 -0.3 -0.5 -0.6 -0.5 -0.1 -0.8 -0.2 1.0 -0.6 -0.9 -0.2 -0.2
Age started oral contraceptive pill 1.1 1.4 5.4 2.3 1.3 0.4 0.6 0.4 0.7 -0.4 -2.0 1.8 1.2 0.6 0.9 -0.4
Diastolic blood pressure, automated reading 0.1 0.3 1.3 0.3 -0.0 0.1 0.2 0.3 0.3 1.1 1.0 -0.6 -0.6 -0.2 0.3 0.5
Ever depressed for a whole week 0.7 0.9 1.9 1.3 1.2 0.9 1.0 0.7 0.4 0.2 -1.4 -0.6 0.8 0.6 1.4 -1.0
Unable to work because of sickness or disability 2.3 3.0 6.7 -2.1 -1.7 1.5 1.3 1.8 1.6 2.5 1.9 0.5 0.7 1.8 1.0 2.6
Commuting to job workplace: Cycle 0.2 0.2 0.5 -0.4 0.2 0.4 0.7 0.4 0.7 -0.5 -0.2 -0.6 -0.2 0.0 0.6 -0.4
Myopia 0.2 0.3 2.2 1.5 0.2 -0.1 -0.3 -0.4 -0.6 -0.1 0.4 -0.9 0.2 0.4 -0.3 -0.4
Vascular/heart problems diagnosed by doctor 1.0 2.8 9.7 -3.1 -2.9 0.8 0.8 1.1 1.4 0.3 1.6 -0.0 -2.7 -1.3 0.2 1.6
Cholesterol lowering medication 1.0 1.4 3.3 0.9 0.3 -1.2 -1.2 -1.5 -1.3 -1.8 -0.8 -0.3 -0.8 -1.5 -1.0 -1.6
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.9 0.1 0.2 -0.6 -0.6 -0.8 -1.0 -1.4 0.1 -0.9 -0.3 -0.4 -1.1 -1.2
Pain experienced in last month 0.8 1.4 5.7 -0.8 -1.0 -1.1 -1.1 -1.1 -0.6 -0.9 -0.3 0.8 -2.1 -2.4 -1.1 -0.2
Supplements: Calcium 0.2 0.2 0.6 -0.7 -0.2 0.2 0.1 0.3 0.2 0.2 0.8 0.2 0.3 0.4 -0.3 0.7
Basal cell carcinoma (self-reported) 0.8 0.9 2.1 1.5 0.6 -0.9 -1.2 -1.1 -1.2 -1.4 -0.5 0.1 0.3 -0.4 -1.2 -0.7
Heart attack/myocardial infarction (self-reported) 2.0 2.5 11.3 1.7 3.0 -0.1 -0.2 -0.5 -0.6 -0.3 -1.7 -0.0 3.4 2.1 -0.1 -1.4
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 4.9 2.0 1.5 -1.1 -1.1 -1.5 -1.2 -1.8 -2.2 -1.4 -0.2 -0.9 -1.3 -2.1
Heart disease (siblings) 0.1 0.1 0.5 -0.7 0.3 0.3 0.1 0.1 0.6 -0.3 0.0 -0.1 0.0 0.2 0.1 0.1
Alcohol drinker status: Previous 1.5 1.7 3.9 -2.0 -1.8 1.1 1.1 1.4 1.6 1.8 0.7 0.1 -0.9 0.4 0.4 2.0
Pack years of smoking 0.5 0.8 2.1 0.2 1.0 0.9 0.9 0.8 0.6 1.1 -0.7 -0.2 1.2 1.4 1.2 0.1
Impedance of whole body 1.5 7.7 17.2 -3.0 -2.1 -3.3 -3.5 -3.0 -2.5 -2.1 2.4 2.5 -2.1 -3.3 -4.2 0.1
Leg fat mass (left) 0.3 1.0 3.0 1.7 1.2 0.7 0.8 0.5 0.5 0.7 -1.5 -0.8 0.8 0.8 1.2 -1.0
Arm predicted mass (left) 1.0 4.8 10.8 0.4 -0.6 3.0 3.0 3.0 3.0 2.3 -0.1 -2.1 -0.4 1.9 3.3 1.4