Hub : Genes

BRI3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0816	0.0304	1.3e-04	0.011	NA	0.012	NA	0.008	4.6e-02	NA	3.9e-02	NA	7.8e-02
2	GTEx	Cells Transformed fibroblasts	0.2560	0.0490	6.3e-15	0.156	NA	0.249	NA	0.204	9.3e-12	NA	1.1e-18	NA	3.0e-15
3	GTEx	Colon Transverse	0.1680	0.0660	5.8e-03	0.160	NA	0.067	NA	0.146	4.6e-08	NA	4.2e-04	NA	1.8e-07
4	GTEx	Liver	0.3930	0.1160	2.9e-03	0.369	NA	0.288	NA	0.366	3.2e-11	NA	1.0e-08	NA	3.9e-11
5	GTEx	Pancreas	0.1680	0.0710	1.4e-03	0.174	NA	0.046	NA	0.153	8.1e-08	NA	5.1e-03	NA	5.4e-07
6	GTEx	Thyroid	0.1080	0.0390	5.4e-05	0.046	NA	0.056	NA	0.060	1.9e-04	NA	4.0e-05	NA	2.3e-05
7	METSIM	Adipose	0.0748	0.0219	2.9e-07	0.069	0.049	0.077	0.065	0.068	1.7e-10	6.0e-08	1.1e-11	5.0e-10	2.4e-10
8	YFS	Blood	0.0564	0.0157	3.7e-12	0.031	0.047	0.042	0.046	0.038	1.9e-10	2.9e-15	9.0e-14	8.9e-15	1.6e-12
9	TCGA	Bladder Urothelial Carcinoma	0.1340	0.0780	1.6e-03	0.028	0.037	0.047	NA	0.045	1.9e-03	4.1e-04	7.3e-05	NA	1.0e-04
10	TCGA	Breast Invasive Carcinoma	0.0646	0.0381	2.8e-04	0.025	0.019	0.017	NA	0.018	6.7e-06	7.6e-05	1.8e-04	NA	8.3e-05
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.0942	0.0523	2.9e-03	0.008	0.030	0.021	NA	0.026	3.6e-02	2.1e-04	1.9e-03	NA	6.3e-04
12	TCGA	Liver Hepatocellular Carcinoma	0.5450	0.1490	3.6e-06	0.109	0.139	0.152	NA	0.123	8.3e-06	4.6e-07	1.2e-07	NA	2.2e-06
13	TCGA	Thyroid Carcinoma	0.0400	0.0270	9.0e-05	0.053	0.046	0.040	NA	0.047	6.2e-06	2.5e-05	7.7e-05	NA	2.1e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	1.4	2.2	5.4	-2.3	-1.4	1.1	0.9	1.4	1.3	1.9	1.9	0.4	-0.1	1.2	1.2	2.3
Bipolar Disorder or Schizophrenia	0.9	2.3	5.9	-0.7	-0.7	2.0	2.0	1.8	1.6	1.2	1.8	-1.6	-0.9	0.8	2.4	0.5
Depressed Affect (Nagel 2018)	1.1	2.3	4.6	2.0	1.9	-1.3	-1.4	-1.7	-2.1	-1.7	-0.8	0.3	1.2	-0.5	-1.3	-2.0
Depression (Nagel 2018)	0.2	0.3	1.1	0.6	1.0	-0.3	-0.2	-0.2	-0.8	0.0	-0.1	0.5	1.0	0.2	-0.3	-0.4
Intelligence (Savage-Jansen 2018)	0.5	1.7	5.8	0.9	-0.2	1.6	1.6	1.6	2.4	1.1	-1.5	-0.3	-0.2	0.7	1.8	0.6
Neuroticism (Nagel 2018)	3.5	8.2	16.6	3.9	4.1	-2.4	-2.4	-2.9	-3.7	-3.0	-2.0	0.6	2.8	-0.4	-1.9	-4.1
Schizophrenia (2018)	0.9	1.8	5.5	1.0	-0.0	1.7	1.9	1.2	1.1	-0.0	0.7	-2.3	-1.1	0.1	2.1	-1.2
Schizophrenia vs Biploar Disorder	0.4	0.6	1.8	0.8	0.4	0.9	1.0	0.7	0.6	0.5	0.9	-1.3	-0.0	0.6	1.0	-0.4
Worry (Nagel 2018)	4.7	9.9	19.1	4.2	3.9	-3.1	-3.0	-3.5	-4.4	-3.4	-2.0	1.0	2.5	-0.9	-2.4	-4.1
Alzheimer’s Disease (in mother)	0.5	0.6	1.7	-0.5	0.9	-0.1	-0.2	0.0	0.1	0.6	-1.2	1.3	1.2	0.9	-0.5	0.7
Alzheimer’s Disease (in father)	0.5	0.5	1.8	-0.7	-0.2	0.7	0.4	0.6	0.5	0.9	1.1	-0.3	0.7	1.3	0.3	1.0
Alzheimer’s Disease (including proxy)	0.4	0.6	2.8	-0.4	0.4	-0.1	-0.3	-0.1	-0.0	0.4	-0.7	1.2	1.7	1.2	-0.9	0.8
Crohns Disease (2017)	0.3	0.6	3.2	-1.6	-1.8	0.1	0.2	0.2	0.6	-0.4	0.4	-0.7	-0.9	-0.2	0.2	0.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.0	-0.3	0.1	-0.6	-0.6	-0.8	-0.6	-0.9	-1.0	0.0	0.7	0.0	-0.8	-1.0
Ulcerative Colitis (UC)	1.1	2.1	4.1	0.9	1.8	-1.2	-1.2	-1.5	-1.9	-1.3	-1.7	0.7	1.7	-0.1	-1.3	-2.0
Major Depression (MDD)	0.1	0.1	0.3	0.4	0.6	-0.3	-0.4	-0.4	-0.2	-0.0	0.2	0.2	0.5	0.0	-0.4	-0.4
Reaction Time	0.8	1.6	6.8	0.6	2.6	-0.1	-0.4	-0.5	-0.9	-0.4	-1.5	1.2	2.5	1.3	-0.2	-0.6
Verbal and Numeric Reasoning (VNR)	1.1	2.7	6.7	0.6	-0.3	2.2	2.2	2.1	2.6	1.8	-0.7	-0.6	0.5	1.6	2.4	1.1
Breast Cancer	1.3	3.2	13.1	-3.0	-1.5	-0.4	-0.4	0.5	0.5	1.7	0.9	3.6	0.8	0.7	-1.0	3.3
Ovarian Cancer	0.9	1.2	4.7	-1.9	-1.6	0.4	0.2	0.7	0.8	0.9	1.1	0.8	-0.7	0.3	-0.2	2.2
Prostate Cancer	16.6	23.3	41.0	-5.5	-5.1	5.0	5.0	5.7	6.4	6.2	3.4	-1.8	-1.9	2.9	4.7	6.0
Age at First Birth	0.1	0.1	0.4	0.7	0.6	-0.0	0.0	0.0	0.1	0.2	-0.4	-0.3	-0.2	-0.0	0.4	-0.0
Bipolar Disorder (2011)	0.8	0.8	1.8	-1.0	-0.9	1.0	0.9	1.0	1.4	0.4	0.5	-0.2	-0.5	0.3	1.1	1.2
Body Mass Index (BMI) (2010)	0.4	0.5	0.8	0.9	0.8	0.8	0.8	0.7	0.8	0.4	-0.8	-0.8	0.3	0.8	0.7	-0.1
Coronary Artery Disease (CAD)	0.4	0.4	2.4	0.0	1.0	-0.3	-0.2	-0.1	0.1	0.1	-0.9	1.6	1.0	0.0	0.2	-0.5
Crohns Disease (2012)	0.6	1.0	2.4	-1.2	-1.5	0.9	1.0	1.0	1.4	0.1	0.4	-1.1	-1.2	-0.2	0.9	0.3
Mean Putamen Volume	1.0	1.1	3.1	-0.2	-1.1	-0.5	-0.8	-0.9	-1.4	-0.9	1.0	-1.1	-1.8	-1.6	-0.5	-0.8
Fasting Glucose	1.9	2.2	4.1	1.0	1.8	-1.5	-1.5	-1.8	-2.0	-2.0	-1.2	-0.7	1.0	-0.4	-1.4	-2.0
HbA1C	1.3	1.5	3.1	0.2	-0.2	-1.6	-1.5	-1.6	-1.3	-1.6	0.3	-0.7	-0.9	-1.8	-1.3	-1.1
HDL Cholesterol	0.1	0.1	0.5	-0.6	-0.3	-0.1	0.0	0.2	0.2	0.2	0.6	0.2	-0.0	-0.0	-0.2	0.7
LDL Cholesterol	5.0	8.0	15.9	0.3	-0.6	-3.9	-4.0	-4.0	-3.6	-3.6	-0.1	0.9	-1.2	-3.0	-3.8	-2.3
Lupus	1.3	1.9	6.3	-1.7	-2.5	-0.3	-0.3	0.1	0.4	0.1	2.5	-0.8	-2.4	-1.1	-0.3	1.3
Neuroticism (2016)	1.3	1.8	3.8	0.6	1.3	-1.4	-1.6	-1.7	-1.9	-1.5	-1.1	1.6	1.3	-0.4	-1.1	-1.1
Primary Biliary Cirrhosis	0.3	0.4	1.3	-0.3	-0.4	0.8	0.9	0.7	0.8	0.3	0.4	-0.7	-0.6	-0.0	1.1	-0.1
Rheumatoid Arthritis	0.4	0.5	1.2	-0.2	0.3	-0.8	-0.6	-0.7	-0.9	-1.1	0.6	-0.5	-0.5	-0.9	-0.7	-0.8
Schizophrenia (2014)	1.2	2.7	5.8	-0.3	-0.1	2.2	2.3	1.9	1.8	1.1	1.9	-2.3	-1.3	0.5	2.4	-0.1
Triglycerides	0.4	0.6	1.2	0.6	-0.0	-1.1	-1.1	-1.1	-1.1	-0.8	0.0	1.1	0.4	-0.4	-0.5	-0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.8	-0.2	-0.8	-0.2	-0.4	-0.3	-0.2	-0.4	0.1	-0.5	-0.9	-0.6	-0.2	0.0
Ulcerative Colitis	0.5	0.8	3.8	0.9	1.4	0.1	0.0	-0.2	-0.6	0.1	-0.7	0.0	2.0	1.3	-0.3	-0.8
Blood Eosinophil Count	0.6	4.3	19.4	2.8	2.1	-1.1	-0.9	-1.6	-1.3	-2.0	-4.4	-1.1	0.5	-1.1	-0.6	-3.3
Blood Platelet Count	0.3	3.8	8.5	1.0	-0.8	-2.3	-2.5	-2.6	-1.9	-2.9	-1.1	-0.8	-1.3	-2.3	-2.1	-1.9
Blood Red Count	0.7	6.5	24.5	-1.9	-0.8	-3.3	-3.4	-2.6	-2.7	-1.0	-0.0	5.0	-0.7	-2.7	-3.1	1.2
Blood White Count	1.2	9.1	24.6	-3.3	-4.5	2.4	2.3	2.2	2.4	1.9	2.4	-4.9	-5.0	-1.1	1.9	1.7
Heel T-Score	1.9	15.2	29.1	0.0	-0.4	5.4	5.3	5.1	5.1	4.5	0.6	-4.3	0.9	4.5	4.8	2.1
BMI	0.5	2.8	5.5	1.9	1.3	1.8	1.9	1.5	1.2	1.6	-2.4	-0.8	1.7	2.1	2.0	-0.5
Height	0.1	2.7	9.7	-1.5	-3.1	0.1	-0.1	0.3	0.8	-0.4	2.1	0.8	-3.1	-1.9	-0.6	2.0
Waist Hip Ratio (WHR)	1.3	5.9	12.0	0.3	-1.6	-2.5	-2.8	-3.0	-2.7	-3.5	-0.7	-1.3	-2.2	-3.4	-2.8	-2.2
Systolic Blood Pressure	0.4	1.8	8.4	-0.6	-0.8	1.1	0.8	1.1	0.7	1.9	2.9	-0.7	-0.2	1.1	1.0	1.9
Smoking Status	2.4	5.8	15.9	-3.5	-4.0	2.0	1.8	2.2	2.6	2.5	2.7	-0.8	-1.9	0.5	1.5	2.9
Allergy or Eczema	1.9	5.0	13.5	3.7	3.6	-1.3	-1.1	-1.8	-1.6	-1.7	-3.4	-0.4	1.6	-0.2	-0.7	-3.5
Cardiovascular Disease	0.9	2.8	6.8	2.6	0.5	-2.0	-2.1	-2.2	-2.6	-1.2	-0.9	0.2	0.7	-0.7	-1.8	-1.8
Hypothyroidism (self reported)	0.9	2.0	4.7	-0.9	-1.9	-1.2	-1.4	-1.1	-1.5	-0.9	1.6	1.2	-1.6	-1.7	-2.2	0.4
Respiratory disease	0.7	1.5	4.9	2.2	1.4	-0.8	-0.9	-1.2	-1.2	-0.9	-1.5	-0.0	1.3	0.3	-0.7	-1.6
Type 2 Diabetes (T2D) (2018)	0.9	1.6	4.1	-0.0	0.0	-1.7	-2.0	-1.9	-1.6	-1.2	-0.7	1.4	0.1	-1.1	-1.8	-0.4
Lung FEV1/FVC ratio	0.3	1.3	5.8	-0.8	-1.8	0.4	0.5	0.5	0.9	0.1	1.0	-2.4	-2.0	-0.8	0.2	0.6
Lung FVC	0.4	2.1	8.6	-1.3	-0.7	-1.4	-1.5	-1.1	-1.4	-0.5	1.9	2.9	-0.6	-1.5	-1.4	0.8
Neuroticism	1.2	2.9	8.2	2.9	2.3	-1.1	-1.1	-1.5	-2.2	-1.3	-1.1	0.4	2.1	0.2	-0.7	-2.4
Chronotype (morning person)	1.6	3.8	7.8	-2.6	-2.4	1.5	1.4	1.8	1.7	2.5	2.8	-0.6	-1.8	0.4	1.2	2.8
Hair Pigment	0.1	1.5	3.8	1.6	0.9	-1.0	-0.9	-1.1	-1.3	-1.4	-1.3	0.5	0.1	-1.2	-2.0	-1.6
Tanning	0.5	6.7	10.5	-3.2	-2.9	2.8	2.7	3.1	3.2	2.6	1.8	-1.3	-1.3	1.6	2.5	3.2
Hand grip strength (left)	1.2	3.1	7.2	-2.0	-2.4	1.4	1.3	1.7	2.0	2.1	1.9	-0.5	-1.2	0.9	1.2	2.7
Number of treatments/medications taken	0.9	1.7	4.7	1.8	1.9	-0.7	-0.6	-0.8	-1.0	-0.5	-1.9	1.3	2.2	0.8	-0.3	-1.2
Average weekly spirits intake	1.2	1.5	5.7	-0.9	-1.0	1.2	1.3	1.5	1.7	2.4	0.1	0.6	0.0	0.9	0.9	1.5
Sensitivity / hurt feelings	2.0	3.4	9.7	2.7	2.4	-1.1	-1.2	-1.8	-2.4	-2.2	-1.2	-0.4	1.2	-0.7	-1.1	-3.1
Frequency of depressed mood in last 2 weeks	0.7	0.9	4.8	0.4	1.6	-0.3	-0.3	-0.3	-0.9	0.4	0.1	1.3	2.2	0.9	-0.6	-0.3
Hearing difficulty/problems: Yes	0.2	0.4	1.3	0.5	0.4	-0.6	-0.5	-0.6	-1.1	-0.4	-0.2	-0.4	0.1	-0.3	-0.9	-0.9
Relative age of first facial hair	0.7	1.3	2.8	1.2	-0.7	-1.4	-1.4	-1.3	-1.4	-1.5	0.4	0.0	-0.8	-1.7	-1.2	-0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	1.1	0.8	-1.1	0.4	0.4	0.5	0.2	0.2	0.2	0.9	-0.4	-0.3	0.3	0.9
Ever used hormone-replacement therapy (HRT)	0.7	0.9	4.1	-0.3	-1.7	0.5	0.5	0.3	0.5	0.4	0.7	-1.6	-2.0	-1.0	0.4	-0.1
Ever had hysterectomy (womb removed)	0.4	0.5	1.9	0.6	-0.5	0.5	0.5	0.3	0.8	-0.3	-1.4	-1.2	-0.4	-0.0	0.7	-0.3
Systolic blood pressure, automated reading	0.7	2.0	5.0	0.4	1.0	1.6	1.5	1.6	1.4	2.2	1.2	-0.4	0.9	1.7	1.8	1.2
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.3	0.3	-0.4	1.4	1.4	1.2	1.1	1.1	0.7	-1.8	-0.3	0.8	1.6	-0.0
Angina	0.5	0.7	1.3	1.1	0.5	-1.0	-0.9	-1.0	-1.0	-0.9	-1.1	0.1	0.9	0.3	-0.5	-0.7
Medication for hormone replacement therapy	0.2	0.2	2.0	-0.2	-0.0	0.3	0.2	0.1	0.5	0.0	-1.4	0.1	0.2	0.2	0.2	-0.2
Vitamin and mineral supplements	5.2	7.0	13.8	3.0	0.5	-2.7	-2.7	-3.2	-3.1	-3.6	-1.8	-1.1	-1.3	-3.1	-2.3	-3.7
Supplements: Zinc	0.9	0.9	3.7	-1.9	-0.8	0.3	0.4	0.7	0.6	1.0	1.1	1.7	-0.3	-0.2	0.1	1.3
Medication: Co-codamol	1.1	1.3	4.5	-0.5	-1.2	1.3	1.5	1.3	1.2	0.7	0.1	-2.1	-1.1	-0.0	1.5	0.1
Medication: Metformin	1.6	2.3	4.4	0.5	0.8	-1.9	-2.1	-2.1	-1.7	-1.7	-1.9	1.2	0.5	-1.0	-1.8	-1.1
Diabetes (father)	0.8	1.0	2.9	-0.9	1.2	1.1	0.9	0.9	0.6	1.1	0.7	-1.1	1.1	1.7	0.6	0.5
Diabetes (mother)	1.4	1.8	3.8	0.4	0.7	-1.6	-1.6	-1.8	-1.9	-1.4	0.5	1.2	-0.0	-1.6	-1.2	-1.7
Severe depression (siblings)	0.8	0.9	3.6	1.9	0.9	-0.7	-0.7	-0.9	-1.1	-1.0	-0.6	0.8	0.2	-0.7	-0.7	-1.3
Pack years adult smoking proportion	0.3	0.4	1.0	-0.6	0.1	0.7	0.6	0.7	0.5	1.0	0.2	-0.1	0.5	1.0	0.8	0.5
Impedance of leg (right)	0.6	2.9	7.1	-2.7	-1.7	-1.7	-2.0	-1.5	-1.0	-0.6	2.1	1.9	-0.9	-1.4	-2.4	0.9
Leg fat-free mass (left)	0.4	1.9	5.2	0.7	-0.8	1.9	2.0	1.8	1.7	1.0	-0.2	-1.6	-0.8	0.6	2.3	0.5
Trunk fat percentage	0.2	0.8	3.4	1.0	0.9	-0.8	-0.7	-1.0	-0.5	-0.6	-1.3	-0.1	-0.2	-0.9	-0.7	-1.9
Hand grip strength (right)	1.0	2.8	6.4	-1.1	-2.2	1.5	1.6	1.9	2.0	2.0	1.2	-0.9	-1.4	0.8	1.4	2.5
Townsend deprivation index at recruitment	0.9	1.3	3.0	-1.7	-1.2	1.0	1.0	1.2	1.0	1.5	0.8	-0.8	-0.1	1.1	0.9	1.6
Current tobacco smoking	1.8	2.9	8.1	-2.9	-2.3	1.4	1.2	1.6	1.9	2.2	1.6	-0.6	-0.5	1.1	0.9	2.3
Average weekly fortified wine intake	0.4	0.5	1.8	1.3	0.9	0.4	0.4	0.1	0.2	-0.0	-1.3	-0.2	0.4	0.2	0.3	-1.0
Maternal smoking around birth	1.1	1.6	3.2	-0.9	-0.6	1.4	1.4	1.5	1.8	1.5	-0.6	-0.8	0.3	1.4	1.7	1.3
Fed-up feelings	0.3	0.6	3.0	0.8	1.2	-0.3	-0.5	-0.5	-0.9	-0.0	-0.5	0.6	1.7	0.8	-0.4	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	1.2	-0.0	0.7	-0.1	-0.1	-0.0	-0.5	0.3	-0.1	0.5	1.1	0.4	-0.2	-0.1
Relative age voice broke	0.6	1.0	2.3	0.6	-0.9	-1.2	-1.2	-1.1	-0.9	-1.4	0.1	0.7	-0.8	-1.5	-0.8	-0.5
Taking other prescription medications	0.2	0.2	0.8	-0.3	-0.6	0.1	0.2	0.3	-0.3	0.9	0.8	0.6	0.1	0.3	0.0	0.6
Age when periods started (menarche)	0.2	0.5	1.4	0.4	0.3	0.9	0.9	0.9	1.0	0.6	0.1	0.7	0.3	0.5	1.2	0.5
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	4.5	-0.8	-1.2	1.4	1.4	1.1	1.6	0.5	-0.5	-2.1	-1.0	0.2	1.7	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.3	-0.0	0.4	0.8	0.6	0.8	0.7	1.2	-0.6	1.1	1.3	1.5	0.5	1.1
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	4.5	2.0	1.4	-0.5	-0.5	-0.9	-1.4	-1.1	-0.5	-0.0	0.9	-0.3	-0.1	-2.1
Qualifications: CSEs or equivalent	0.5	0.7	2.0	-0.4	-0.5	-0.7	-0.8	-0.9	-0.9	-0.2	0.0	-1.4	-0.9	-1.1	-0.9	-0.7
Serious illness, injury or assault to yourself	0.1	0.1	0.4	0.4	-0.6	0.0	0.2	0.2	0.0	0.1	0.1	-0.3	-0.2	0.0	0.1	0.1
High blood pressure	0.6	1.6	7.3	2.7	2.2	-0.6	-0.6	-0.7	-1.0	0.2	-0.8	-0.1	2.1	1.1	-0.1	-0.9
Hayfever, allergic rhinitis or eczema	1.2	2.5	5.8	2.3	1.8	-1.3	-1.2	-1.6	-1.5	-1.7	-2.4	-0.1	0.4	-0.9	-1.0	-2.4
Multivitamins +/- minerals	2.4	3.1	6.5	-2.5	-1.0	1.6	1.6	2.0	2.0	2.1	2.2	0.6	0.1	1.6	1.2	2.5
Stomach or abdominal pain in last month	0.4	0.6	1.8	0.7	0.8	0.5	0.7	0.7	-0.1	0.7	0.8	0.1	1.4	1.2	0.6	0.2
Supplements: Glucosamine	2.3	2.9	6.3	0.1	0.2	2.1	2.3	2.3	2.5	2.3	-0.3	0.0	0.6	1.9	2.5	1.4
Diverticular disease/diverticulitis (self-reported)	2.4	2.8	4.8	1.5	0.7	-1.9	-1.9	-2.1	-1.8	-2.1	-2.2	0.6	0.0	-1.7	-1.5	-2.0
Medication: Atenolol	0.5	0.7	1.4	0.4	0.9	-1.0	-1.0	-1.1	-0.6	-1.0	-1.2	0.3	0.5	-0.0	-0.9	-0.8
Medication: Levothyroxine sodium	1.3	2.3	4.2	0.1	-1.3	-1.6	-1.8	-1.8	-1.8	-1.9	0.9	0.7	-1.5	-2.0	-1.9	-1.0
Sitting height	0.6	4.4	12.8	-1.9	-3.6	1.5	1.3	1.8	2.1	1.8	2.8	0.3	-2.7	-0.4	1.0	3.0
Chronic bronchitis/emphysema (father)	0.6	0.7	2.2	-0.9	-0.4	1.2	1.1	1.0	0.9	0.7	0.8	-1.5	-0.5	0.5	0.7	0.2
High blood pressure (mother)	2.1	3.0	6.0	1.1	1.1	-2.4	-2.4	-2.3	-2.1	-1.8	-1.2	1.6	0.9	-0.9	-2.4	-0.8
Body mass index (BMI)	0.5	2.3	6.2	2.5	1.9	1.1	1.3	0.8	0.7	0.7	-2.4	-1.6	1.0	1.1	1.7	-1.4
Impedance of leg (left)	0.7	3.5	8.5	-2.9	-1.6	-2.0	-2.2	-1.7	-1.4	-0.7	2.3	1.8	-1.0	-1.6	-2.7	0.7
Leg predicted mass (left)	0.3	1.8	5.2	0.7	-0.7	1.8	1.9	1.8	1.7	0.9	-0.1	-1.5	-0.8	0.6	2.3	0.5
Trunk fat mass	0.1	0.4	1.5	1.0	0.5	-0.0	0.1	-0.2	0.2	0.0	-1.2	-0.5	-0.3	-0.4	0.2	-1.2
Waist circumference	0.3	0.9	3.4	1.3	-0.3	0.2	0.2	-0.2	-0.1	-0.7	-1.3	-1.9	-1.1	-0.9	0.4	-1.6
Number of incorrect matches in round	1.4	2.4	7.9	1.6	2.8	-0.1	-0.0	-0.4	-0.7	0.4	-2.5	-0.7	2.8	1.8	-0.5	-1.4
Past tobacco smoking	1.4	2.5	4.4	1.7	1.4	-1.9	-1.8	-1.8	-1.8	-1.3	-2.1	1.1	0.7	-1.0	-1.8	-1.4
Alcohol usually taken with meals	0.5	0.8	3.2	-0.0	-1.1	0.6	0.6	0.7	0.9	0.6	1.5	-0.6	-1.8	-0.5	0.2	0.8
Nervous feelings	5.8	10.7	19.8	4.5	3.5	-3.6	-3.6	-3.9	-4.3	-3.4	-1.7	1.2	2.3	-1.1	-3.5	-3.6
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	9.0	0.8	1.9	1.1	1.2	1.1	0.5	1.7	0.6	0.2	3.0	2.5	1.2	0.1
Hearing difficulty/problems with background noise	1.6	2.6	7.1	1.5	1.6	-1.5	-1.5	-1.9	-2.6	-1.5	-0.4	-0.7	1.2	-0.3	-1.7	-2.7
Hair/balding pattern: Pattern 2	0.9	1.1	3.0	0.4	-0.3	1.0	1.4	1.4	1.4	0.8	0.8	-1.7	-0.8	0.4	1.5	0.7
Had menopause	1.0	1.3	2.2	1.3	1.0	1.5	1.5	1.2	1.5	0.9	-1.0	-0.2	0.7	1.3	1.3	-0.2
Had other major operations	0.1	0.1	0.4	-0.2	-0.4	-0.3	-0.2	-0.3	-0.1	0.1	-0.7	-0.5	-0.5	-0.3	-0.3	-0.1
Forced vital capacity (FVC)	1.0	4.0	12.9	-2.6	-3.6	-1.1	-1.2	-0.5	-0.6	-0.1	2.8	2.0	-2.6	-2.2	-1.3	1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.0	-0.4	0.0	0.8	0.7	0.9	1.0	1.3	0.2	0.5	0.9	1.4	0.3	1.4
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	3.6	1.9	1.8	-1.2	-1.2	-1.4	-1.8	-1.3	-1.5	1.2	1.4	-0.4	-0.7	-1.8
Qualifications: None of the above	0.2	0.5	1.6	-1.2	0.4	-0.6	-0.6	-0.6	-0.9	0.3	-0.8	0.5	1.1	0.5	-0.5	-0.3
Financial difficulties in last 2 years	0.7	0.9	5.5	-0.5	-0.8	0.9	0.8	1.0	0.3	0.9	2.3	0.4	0.1	0.7	0.7	1.0
Mouth/teeth dental problems	0.2	0.3	1.1	0.1	-0.0	-0.4	-0.3	-0.4	0.1	-0.4	-1.0	0.0	-0.7	-0.9	-0.2	-0.6
Heart attack	1.8	2.3	9.8	1.6	2.8	-0.0	-0.1	-0.4	-0.4	-0.3	-1.7	-0.1	3.1	2.0	-0.1	-1.3
Allergy	1.2	2.7	6.2	-2.4	-1.8	1.5	1.4	1.8	1.7	1.8	2.2	0.5	-0.5	0.7	1.1	2.5
Pain all over the body in last month	0.5	0.5	1.5	-0.8	0.5	-1.0	-0.9	-0.8	-0.9	-0.1	0.2	0.6	0.3	-0.2	-1.2	0.1
Diabetes (self-reported)	0.2	0.3	1.3	-0.0	0.3	-0.3	-0.6	-0.7	-0.3	-0.6	-1.1	0.1	0.4	-0.0	-0.4	-0.5
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	5.7	1.9	0.6	-0.0	-0.1	-0.4	0.1	-0.5	-2.4	0.3	0.6	-0.1	0.2	-1.1
Medication: Ramipril	0.3	0.4	1.4	1.0	0.6	0.4	0.2	0.2	-0.0	0.4	0.1	-0.6	1.1	1.2	0.7	-0.0
Medication: Simvastatin	0.2	0.3	1.4	0.2	0.3	-0.1	-0.3	-0.6	-0.5	-0.6	-0.4	-1.0	-0.2	-0.4	-0.2	-1.2
Fluid intelligence score	0.4	0.8	3.0	-0.0	-1.2	0.9	0.9	0.9	1.7	0.5	-0.4	-0.5	-0.9	-0.0	1.0	0.7
Illnesses of siblings	0.4	0.6	2.1	1.1	0.2	-0.6	-0.5	-0.6	-0.5	-1.5	-1.1	0.5	0.2	-0.6	-0.4	-0.9
Neuroticism score	1.4	2.9	7.7	2.8	2.7	-1.0	-1.0	-1.4	-2.1	-1.2	-1.1	-0.1	2.3	0.5	-0.8	-2.3
Weight	0.2	0.8	2.1	0.9	-0.3	1.1	1.2	1.0	1.0	0.7	-0.6	-1.4	-0.7	0.1	1.4	-0.3
Impedance of arm (right)	1.8	8.6	16.9	-2.4	-1.8	-3.6	-3.8	-3.4	-3.1	-2.7	1.8	3.0	-2.0	-3.7	-4.1	-0.4
Arm fat percentage (right)	0.4	1.7	5.6	2.4	1.9	-0.7	-0.4	-0.9	-0.8	-0.7	-2.3	-0.0	0.7	-0.4	-0.1	-2.2
Trunk fat-free mass	0.7	4.2	9.5	-0.0	-1.3	2.8	2.8	2.8	2.7	1.9	0.5	-1.9	-0.9	1.4	3.1	1.6
Hip circumference	0.2	0.7	1.6	0.6	-0.5	1.0	1.2	1.0	1.1	1.1	0.0	-0.9	-0.6	0.2	1.3	-0.0
Time employed in main current job	1.4	1.6	2.9	0.3	-1.6	-1.5	-1.6	-1.5	-0.7	-1.7	0.6	0.3	-1.3	-1.7	-1.7	-0.1
Alcohol intake versus 10 years previously	0.5	0.8	3.3	-0.9	-0.5	-0.9	-1.0	-0.6	-0.8	-0.3	1.8	1.0	0.3	0.1	-0.8	1.1
Father’s age at death	0.4	0.6	2.0	-0.1	-0.5	-0.9	-0.8	-0.6	-0.7	-0.3	1.1	1.4	0.3	-0.6	-1.1	0.3
Worrier / anxious feelings	1.8	3.5	7.4	2.7	2.4	-1.4	-1.6	-1.9	-2.7	-2.0	-0.7	0.6	1.9	0.0	-1.5	-2.4
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	10.0	3.2	2.6	-1.2	-1.2	-1.4	-2.2	-0.8	-1.0	0.8	2.8	0.6	-0.9	-2.0
Falls in the last year	3.0	4.1	7.4	-0.7	-0.6	2.6	2.6	2.7	2.6	2.4	-0.8	-0.2	1.0	2.7	2.4	2.3
Hair/balding pattern: Pattern 3	2.1	3.2	7.4	2.3	2.7	-1.1	-1.2	-1.7	-1.7	-1.2	-2.6	1.2	2.0	-0.0	-0.9	-2.5
Number of live births	0.3	0.5	1.8	0.0	-0.1	-0.0	-0.1	-0.4	-0.7	-0.8	0.1	-1.4	-0.8	-0.7	-0.1	-1.3
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	10.2	-2.2	-3.2	-1.2	-1.2	-0.7	-0.7	-0.6	2.5	1.0	-2.8	-2.6	-1.3	1.2
Pulse rate	1.0	1.7	5.9	-2.4	-1.7	0.8	0.9	0.8	0.9	0.8	1.0	-1.6	-2.2	-0.8	0.6	0.2
Happiness	0.7	0.8	2.4	0.5	0.7	-0.8	-1.0	-1.0	-1.3	-1.5	-0.7	0.7	0.1	-0.7	-1.0	-0.9
Noisy workplace	1.1	1.3	5.7	1.4	1.3	-0.2	0.2	-0.4	-0.5	-0.8	-2.2	-0.8	-0.2	-0.9	0.3	-2.4
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.4	1.0	-0.8	0.3	0.2	0.2	0.3	-0.3	1.2	-0.7	-0.8	-0.1	-0.1	0.3
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.7	4.0	1.8	1.7	-1.6	-1.9	-2.0	-2.0	-1.4	-1.8	-0.5	1.7	0.4	-1.8	-1.7
Mouth/teeth dental problems: Dentures	1.6	2.6	6.2	1.0	0.9	1.9	1.9	1.9	1.4	2.0	-0.3	-0.4	1.9	2.5	2.2	0.7
Asthma	0.5	1.0	5.9	2.4	1.1	-0.2	-0.1	-0.5	-0.6	-0.6	-1.2	-0.4	0.5	-0.1	-0.1	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.0	-1.1	0.5	-0.4	-0.5	-0.2	0.2	0.3	-0.6	1.4	1.4	1.0	-0.3	0.8
Medication: Cholesterol lowering	0.9	1.4	5.5	1.0	2.3	-0.8	-1.0	-1.0	-1.1	-0.2	-0.9	0.8	2.2	0.9	-0.8	-0.7
Depression (self-reported)	1.4	1.7	4.5	0.5	2.1	-1.1	-1.0	-1.4	-1.6	-1.1	-1.3	0.3	1.1	-0.5	-1.2	-2.1
Medication: Lansoprazole	0.3	0.4	0.8	-0.7	0.4	0.7	0.9	0.9	0.7	0.8	-0.2	-0.2	0.3	0.8	0.5	0.2
Prospective memory result	1.3	1.6	7.6	1.7	2.8	0.5	0.8	0.3	-0.4	0.2	-0.1	-0.9	2.0	1.4	1.0	-1.3
Lung cancer (father)	0.6	0.6	4.2	-0.1	0.6	0.8	0.7	0.5	0.6	0.3	-2.0	-1.2	-0.1	0.1	0.6	-0.4
Illnesses of mother	1.8	2.2	5.1	-1.0	-0.5	1.8	1.9	1.9	1.7	1.7	1.6	-1.0	-0.2	1.1	2.2	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	11.6	-2.2	-3.4	-0.4	-0.4	-0.0	-0.2	0.1	2.1	-0.0	-2.9	-1.9	-0.5	1.6
Pulse wave Arterial Stiffness index	0.5	0.6	2.1	-0.2	-0.1	0.6	0.9	0.9	1.0	1.4	-0.1	-1.0	0.1	0.7	0.6	0.6
Impedance of arm (left)	2.3	10.5	21.0	-2.9	-2.3	-3.9	-4.0	-3.6	-3.1	-3.0	2.1	2.9	-2.6	-4.3	-4.6	-0.5
Arm fat mass (right)	0.3	1.0	4.2	1.9	1.2	0.4	0.5	0.1	0.3	0.1	-2.0	-0.8	0.5	0.2	0.9	-1.4
Trunk predicted mass	0.8	4.6	10.3	-0.1	-1.4	3.0	2.9	2.9	2.9	2.0	0.6	-1.9	-0.9	1.5	3.2	1.7
Standing height	0.5	5.4	21.1	-3.2	-4.6	0.4	0.1	0.6	0.9	0.2	3.7	0.1	-3.7	-1.7	-0.2	2.5
Length of working week for main job	1.5	1.6	4.7	-1.7	-2.2	0.9	0.9	1.0	1.4	-0.2	0.4	-1.6	-2.0	-0.6	0.8	0.9
Exposure to tobacco smoke at home	4.1	4.6	8.9	3.0	2.1	-2.2	-2.0	-2.5	-2.9	-2.1	-2.0	-0.2	1.7	-0.5	-1.9	-2.9
Breastfed as a baby	1.9	2.3	6.7	0.8	0.1	0.9	0.5	1.0	1.1	1.4	-0.1	2.6	2.4	2.5	0.9	2.1
Tense / ‘highly strung’	2.5	4.1	14.4	3.7	3.8	-0.2	-0.0	-0.6	-1.3	-0.8	-2.3	-0.4	2.8	1.2	0.6	-2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	4.0	1.6	1.8	-1.1	-0.9	-1.0	-1.4	-0.4	0.7	2.0	1.9	0.2	-0.8	-1.0
Hair/balding pattern: Pattern 4	0.2	0.5	0.9	-0.8	0.6	-0.8	-0.8	-0.8	-0.9	-0.6	0.5	-0.2	-0.1	-0.6	-1.0	-0.5
Birth weight of first child	0.4	0.8	2.2	1.3	1.2	-1.1	-0.8	-0.8	-1.1	-0.4	-0.1	0.2	0.2	-0.6	-1.5	-0.7
Peak expiratory flow (PEF)	0.4	0.9	4.0	-0.6	-2.0	0.2	0.3	0.4	0.3	0.1	0.8	-0.3	-2.0	-1.4	0.2	0.7
Pulse wave reflection index	1.0	1.2	3.1	-0.7	-0.9	0.9	0.9	1.2	1.0	1.7	1.4	-0.7	0.1	1.2	0.6	1.8
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.5	0.3	0.6	0.7	0.8	0.5	0.4	0.2	-1.1	-0.4	0.3	0.1	1.2	-0.7
Loud music exposure frequency	0.7	0.8	3.3	-0.3	1.8	0.4	0.6	0.3	-0.1	0.0	-1.1	-0.0	1.5	1.1	0.8	-1.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.8	0.7	-0.5	0.7	0.6	0.5	0.6	0.1	0.9	-0.8	-0.4	0.1	0.2	0.2
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.2	0.4	0.3	-1.1	-1.1	-1.2	-1.5	-1.5	0.5	-0.2	-0.1	-0.9	-1.2	-1.3
Blood clot in the leg (DVT)	1.3	1.7	3.6	1.9	1.1	-1.0	-1.0	-1.3	-1.1	-1.6	-1.9	-1.3	-0.4	-0.8	-1.2	-1.7
Medication: Paracetamol	0.2	0.3	1.6	-0.0	0.3	-0.3	-0.1	-0.1	-0.6	-0.5	1.1	0.2	1.2	0.8	-0.4	-0.1
Headache pain in last month	0.3	0.5	2.9	0.9	1.1	0.3	0.4	0.3	-0.0	0.0	-0.1	0.3	1.7	1.0	0.4	-0.6
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	6.6	-1.5	-2.6	0.3	0.4	0.5	0.7	-0.4	1.5	-0.1	-2.6	-1.5	0.2	0.8
Glaucoma (self-reported)	0.5	0.6	3.3	0.1	1.5	0.1	0.2	0.4	0.1	0.8	-0.5	1.8	1.0	0.6	0.2	0.7
Gout (self-reported)	1.7	2.4	4.6	1.9	1.8	-1.5	-1.7	-1.7	-1.9	-1.2	-2.1	0.8	1.4	-0.3	-1.1	-1.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.5	0.2	-0.6	-1.2	-1.4	-1.3	-1.5	-1.2	0.7	1.6	-0.5	-1.1	-1.9	-0.2
Medication: Amlodipine	1.8	2.5	11.0	1.7	3.3	0.8	0.7	0.6	0.2	0.9	-1.3	0.4	2.9	2.1	0.9	-0.5
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.9	2.0	1.2	0.8	0.9	0.7	0.6	0.6	-0.7	-0.4	0.8	1.1	1.4	-0.5
Birth weight	0.2	0.4	1.7	0.5	-0.7	0.5	0.4	0.6	0.5	0.9	0.4	1.3	-0.3	-0.1	0.1	1.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	3.6	0.1	1.1	-0.1	-0.1	-0.5	-0.2	-0.6	-1.9	0.2	0.4	-0.5	0.0	-1.5
High blood pressure (siblings)	0.7	1.1	3.4	-0.8	-0.6	0.8	0.8	1.1	0.8	1.7	1.8	-0.1	0.2	0.9	0.6	1.5
Forced vital capacity (FVC), Best measure	0.8	2.9	12.0	-2.4	-3.5	-0.6	-0.7	-0.2	-0.4	0.1	2.2	0.8	-2.7	-1.8	-0.7	1.8
Body fat percentage	0.3	1.1	3.7	1.7	1.4	-0.7	-0.5	-0.9	-0.5	-0.5	-1.8	-0.1	0.4	-0.5	-0.3	-1.9
Leg fat percentage (right)	0.4	1.5	5.3	2.3	2.1	0.3	0.5	0.1	0.3	0.5	-1.9	-0.3	1.5	0.8	0.9	-1.4
Arm fat-free mass (right)	1.0	5.0	10.9	-0.1	-0.9	3.1	3.2	3.0	3.0	2.1	0.1	-2.4	-0.7	1.7	3.3	1.3
Exposure to tobacco smoke outside home	1.5	2.0	4.5	-1.5	-0.8	-1.7	-2.0	-1.7	-1.8	-0.6	0.5	1.7	-0.4	-1.3	-2.1	0.0
Comparative body size at age 10	0.5	1.3	2.7	-0.6	-1.6	-1.5	-1.3	-1.0	-1.0	-0.3	1.1	0.9	-1.1	-1.5	-1.5	0.5
Number of full brothers	1.3	1.6	4.0	0.7	0.0	-1.8	-1.7	-1.6	-1.5	-1.4	0.4	-0.3	-0.7	-1.3	-2.0	-0.8
Worry too long after embarrassment	1.1	1.8	6.5	2.2	2.6	-0.3	-0.4	-0.9	-1.0	-0.5	-0.9	-0.4	2.0	0.8	-0.1	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.2	-0.9	0.1	0.3	0.4	0.6	0.2	1.5	1.3	0.5	0.7	0.8	0.8	1.0
Wheeze or whistling in the chest in last year	1.3	2.4	6.1	2.5	2.3	-1.0	-0.9	-1.2	-1.8	-0.9	-1.7	0.1	2.1	0.5	-0.6	-2.2
Number of children fathered	3.4	3.8	7.7	0.1	-0.5	2.4	2.4	2.5	2.3	2.5	1.0	-0.9	1.3	2.8	2.1	2.0
Reason for reducing amount of alcohol drunk: Health precaution	3.1	3.6	7.2	1.7	1.7	2.7	2.6	2.4	2.0	1.4	-0.6	0.0	1.7	2.5	2.5	0.5
Age at first live birth	0.2	0.4	0.8	-0.2	-0.3	0.4	0.4	0.6	0.8	-0.4	0.4	0.9	-0.8	-0.4	0.9	0.9
Pulse wave peak to peak time	0.5	0.6	2.2	-0.1	-0.0	-0.7	-1.0	-1.0	-1.0	-1.5	0.3	1.1	-0.2	-0.8	-0.7	-0.5
Health satisfaction	0.2	0.3	1.2	0.5	1.1	0.1	0.2	0.1	-0.2	0.2	-0.6	0.4	1.1	0.5	0.1	-0.5
Shortness of breath walking on level ground	0.9	1.1	4.3	2.1	1.8	-0.3	-0.2	-0.6	-0.5	-0.6	-1.0	-0.5	1.2	0.3	-0.3	-1.8
Qualifications: College or University degree	0.3	1.0	1.8	1.0	-0.8	1.0	1.1	1.2	1.2	0.5	0.3	-1.3	-1.2	-0.1	1.3	0.9
Eye problems/disorders: None of the above	0.7	0.8	1.5	0.3	-0.0	-1.2	-1.1	-1.1	-1.0	-0.8	-1.2	1.2	-0.0	-0.9	-0.9	-0.7
Mouth/teeth dental problems: Loose teeth	1.2	1.4	5.6	-2.4	-0.7	1.2	0.8	1.1	1.4	1.0	0.8	-0.2	-0.1	1.2	0.1	2.0
Emphysema/chronic bronchitis	1.3	1.4	3.5	-1.1	-0.5	1.3	1.2	1.3	1.4	1.2	0.5	-0.4	1.1	1.9	1.7	1.0
Medication for pain relief, constipation, heartburn	0.6	0.9	5.1	-0.8	-1.7	0.1	0.2	0.3	0.5	0.4	0.4	-0.3	-2.3	-1.5	0.1	0.8
Neck or shoulder pain in last month	0.5	0.8	3.5	0.5	1.2	0.5	0.6	0.4	0.2	0.2	-1.1	-0.2	1.9	1.5	0.4	-0.3
Medication: Blood pressure	1.2	2.2	10.0	1.7	2.6	-0.0	-0.1	-0.1	-0.5	1.0	-1.4	0.3	3.2	2.3	-0.0	-0.3
Angina (self-reported)	0.2	0.3	1.0	0.7	0.1	-0.5	-0.4	-0.4	-0.4	-0.2	-0.8	0.1	1.0	0.7	-0.0	-0.1
Migraine (self-reported)	2.9	3.6	6.4	0.8	0.6	-2.3	-2.4	-2.5	-2.4	-2.4	-1.3	1.6	-0.0	-1.9	-2.3	-1.8
Medication: Ibuprofen	0.5	0.5	2.7	-1.6	-0.1	-0.2	-0.2	0.1	0.4	0.5	-0.5	1.1	0.8	0.7	-0.1	1.1
Medication: Allopurinol	1.3	1.8	6.1	2.5	1.6	-0.8	-1.0	-1.1	-1.4	-0.8	-2.2	-0.1	1.4	0.3	-0.7	-1.1
Medication: Omeprazole	0.2	0.3	0.8	-0.1	0.3	-0.4	-0.5	-0.6	-0.8	-0.9	0.1	-0.0	0.1	-0.1	-0.8	-0.5
Medication: Seretide 50 evohaler	0.5	0.6	2.3	1.2	0.4	0.6	0.5	0.4	0.5	0.4	-1.2	-0.6	0.4	0.5	1.5	-0.2
Mean time to correctly identify matches	1.2	2.3	9.6	1.2	3.1	-0.2	-0.4	-0.7	-0.8	-0.5	-2.5	1.1	2.4	1.0	0.0	-1.5
Heart disease (mother)	0.5	0.6	1.3	0.9	-1.1	-0.9	-1.0	-0.8	-0.7	-1.0	-0.1	0.3	-0.5	-0.7	-1.0	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	5.0	1.7	2.2	-0.5	-0.4	-0.5	-0.8	-0.2	-1.6	1.1	1.6	0.3	-0.1	-1.0
Whole body fat mass	0.1	0.6	2.2	1.5	0.8	0.1	0.3	-0.0	0.2	0.2	-1.4	-0.8	0.1	-0.0	0.5	-1.3
Leg fat mass (right)	0.3	1.0	3.5	1.9	1.2	0.6	0.8	0.5	0.5	0.6	-1.5	-0.5	1.0	0.9	1.2	-0.9
Arm predicted mass (right)	1.0	4.9	10.6	0.2	-0.9	3.1	3.1	3.0	3.0	2.1	-0.1	-2.2	-0.6	1.8	3.3	1.4
Pulse rate, automated reading	1.7	5.4	21.2	-3.0	-3.7	-1.4	-1.6	-1.4	-0.9	-1.1	1.2	-0.8	-4.6	-3.7	-1.5	0.1
Alcohol intake frequency.	0.6	1.4	4.3	-0.4	0.1	-1.5	-1.5	-1.3	-1.9	-0.9	0.1	1.0	-0.3	-1.2	-2.1	-0.1
Comparative height size at age 10	0.7	3.6	9.1	-2.5	-3.0	1.7	1.2	1.7	2.0	1.7	2.2	-0.4	-1.4	0.8	1.0	3.0
Number of full sisters	0.6	0.8	2.8	-1.7	-1.5	-0.6	-0.7	-0.5	-0.8	-0.4	1.0	0.3	-0.9	-0.9	-0.8	0.4
Suffer from ‘nerves’	6.6	10.3	24.7	3.5	2.6	-3.4	-3.2	-3.9	-4.3	-4.0	-2.4	-0.4	0.9	-2.3	-2.5	-5.0
Overall health rating	1.4	2.9	6.4	1.4	1.7	-2.0	-2.0	-1.9	-2.5	-1.4	-1.3	1.4	2.3	0.2	-1.8	-1.2
Chest pain or discomfort	0.2	0.2	1.1	0.2	0.5	0.2	0.1	0.2	-0.4	0.3	-0.4	1.1	0.9	0.7	-0.0	0.1
Had major operations	0.3	0.3	1.7	0.1	-0.4	0.1	0.3	0.1	0.1	-0.4	-1.3	-1.1	-0.2	-0.1	0.6	-0.5
Age at last live birth	0.3	0.4	1.3	-0.1	-0.2	0.5	0.5	0.6	0.8	0.0	-0.6	0.9	-0.3	0.1	1.1	0.9
Family relationship satisfaction	0.8	1.0	2.6	-0.7	-1.3	-0.8	-1.0	-1.0	-0.9	-1.2	0.6	-0.7	-1.6	-1.4	-0.7	-0.2
Leg pain on walking	1.1	1.4	2.8	0.4	0.7	1.6	1.7	1.6	1.2	1.5	0.2	-1.1	0.4	1.4	1.3	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.6	0.2	-0.4	0.4	0.2	0.2	-0.4	0.5	0.9	-1.3	0.2	0.7	0.4	-0.0
Commuting to job workplace: Car/motor vehicle	0.6	0.7	3.1	0.7	1.0	0.4	0.4	0.3	0.5	0.2	-1.1	1.0	1.8	1.1	0.7	-0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.2	0.5	0.1	0.1	-0.0	0.4	-0.4	-0.1	-0.5	-0.4	-0.4	0.2	-0.4
Medication: Aspirin	0.8	1.1	4.5	1.2	1.5	0.4	0.3	0.3	0.3	0.7	-0.7	0.7	2.1	1.8	0.6	0.2
Supplements: Vitamin C	2.7	3.2	6.5	-0.7	0.3	2.2	2.2	2.3	2.4	2.5	0.0	-0.0	1.3	2.4	2.0	1.5
Knee pain experienced in last month	1.8	2.8	6.3	-0.4	0.3	2.1	2.2	2.0	2.0	1.6	0.3	-2.3	1.2	2.5	1.8	0.6
Hypertension (Self-reported)	0.5	1.4	8.1	2.8	1.8	-0.6	-0.6	-0.7	-1.1	-0.1	-0.6	-0.2	1.5	0.7	-0.1	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.8	0.1	-0.3	-0.0	-0.0	-0.4	-0.3	-1.3	-0.8	-1.9	-1.5	-1.0	0.1	-1.3
Illnesses of father: Heart disease	2.8	3.8	10.5	-0.3	-1.7	-2.0	-2.0	-1.9	-2.0	-2.1	1.2	0.4	-2.9	-3.2	-2.4	-0.8
Illnesses of siblings: Diabetes	0.3	0.4	2.0	0.2	1.4	-0.6	-0.5	-0.6	-0.8	0.3	-0.5	0.3	0.8	0.1	-0.3	-0.6
Smoking status: Previous	1.1	1.7	3.2	-1.1	-0.9	1.7	1.7	1.7	1.7	1.2	1.4	-0.4	-0.4	0.9	1.8	1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	10.2	-1.6	-3.2	-0.8	-0.8	-0.6	-0.6	-0.8	1.8	-0.1	-2.4	-2.0	-0.8	0.5
Whole body fat-free mass	0.7	3.9	9.2	0.3	-1.0	2.7	2.8	2.7	2.6	1.7	0.2	-2.0	-0.9	1.3	3.0	1.2
Leg fat-free mass (right)	0.3	1.5	4.2	0.7	-0.6	1.7	1.8	1.6	1.4	0.8	-0.1	-1.5	-0.8	0.5	2.0	0.4
Arm fat percentage (left)	0.4	1.6	5.2	2.1	1.7	-0.7	-0.5	-0.9	-0.7	-0.8	-2.3	-0.1	0.5	-0.6	-0.2	-2.2
Average weekly red wine intake	1.7	2.4	6.5	-0.9	-2.5	1.6	1.6	1.6	1.4	1.4	2.3	-0.4	-2.1	-0.5	1.4	0.9
Handedness (chirality/laterality): Left-handed	1.2	1.4	4.1	-0.8	0.3	-0.4	-0.6	-0.1	-0.5	1.6	1.5	1.8	2.0	1.5	-0.7	1.4
Mood swings	1.0	1.9	5.9	1.1	2.4	-1.0	-1.1	-1.4	-1.8	-0.9	-0.3	0.4	2.1	0.6	-1.0	-1.7
Loneliness, isolation	0.1	0.2	0.5	0.5	0.1	-0.2	-0.2	-0.3	-0.6	-0.7	0.0	-0.5	-0.2	-0.4	-0.1	-0.5
Long-standing illness, disability or infirmity	0.3	0.4	1.3	0.4	0.8	-0.6	-0.8	-0.6	-0.9	-0.2	-0.2	0.8	1.2	0.3	-0.4	0.0
Ever had bowel cancer screening	2.1	2.5	6.4	1.3	1.5	-1.9	-1.9	-1.7	-1.7	-1.4	-1.0	2.5	1.4	-0.6	-1.8	-0.8
Diabetes diagnosed by doctor	0.4	0.7	2.1	0.1	0.9	-0.6	-1.1	-1.1	-0.8	-0.9	-1.4	0.2	0.8	-0.1	-0.7	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.5	5.3	-0.5	-1.2	-2.0	-2.0	-1.9	-1.7	-2.0	-0.1	-0.0	-2.0	-2.3	-1.7	-0.7
Friendships satisfaction	0.3	0.4	1.3	1.1	0.2	-0.5	-0.7	-0.6	-1.0	-0.9	0.2	0.0	0.0	-0.1	-0.6	-0.3
Qualifications: nursing, teaching	0.6	0.9	3.2	1.8	-0.4	-0.9	-0.8	-0.9	-1.1	-1.4	-0.2	0.4	-0.3	-1.0	-0.9	-0.8
Commuting to job workplace: Walk	1.9	2.1	3.4	-0.5	-1.9	1.7	1.6	1.6	1.4	1.5	1.7	-1.5	-1.5	0.4	1.3	1.3
Eye problems/disorders: Cataract	1.2	1.4	3.3	-0.2	-0.5	1.8	1.6	1.5	1.6	0.8	1.4	-0.8	0.1	1.3	1.3	0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.5	0.4	0.3	-0.7	-0.5	-0.6	-1.0	-0.9	0.4	-0.6	-0.8	-1.2	-0.5	-0.8
Medication for cholesterol	0.5	0.8	2.7	-1.3	-0.3	0.5	0.4	0.8	0.4	1.0	1.4	1.0	0.4	0.7	0.0	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.7	-0.0	0.6	0.9	1.0	0.8	0.6	0.8	-0.1	-0.9	1.0	1.3	1.0	0.0
Back pain experienced in last month	1.5	2.2	4.0	-0.5	-0.3	1.5	1.5	1.8	1.4	1.8	1.2	1.3	1.3	1.9	1.5	2.0
Mineral and other dietary supplements	1.9	2.6	5.7	0.6	0.4	-2.1	-2.2	-2.2	-2.0	-2.4	-0.7	0.1	-0.3	-1.6	-2.1	-1.4
Breast cancer (self-reported)	0.3	0.3	2.5	-0.5	0.9	0.1	0.1	0.0	0.3	0.0	-1.6	-0.0	0.1	-0.1	-0.2	-0.3
Asthma (self-reported)	0.6	1.3	6.0	2.4	1.3	-0.4	-0.4	-0.8	-0.9	-0.9	-1.4	-0.5	0.5	-0.3	-0.2	-1.9
Osteoporosis (self-reported)	0.7	0.9	3.4	0.6	1.3	-0.6	-0.5	-0.6	-0.3	-0.6	-1.3	1.3	1.9	0.5	-0.3	-0.9
Osteoarthritis (self-reported)	1.2	1.5	3.9	0.7	0.9	1.0	1.1	1.3	1.5	1.8	-0.8	0.3	1.7	2.0	0.9	1.2
Medication: Aspirin	0.9	1.2	4.7	1.4	1.7	0.3	0.1	0.1	0.3	0.6	-1.1	0.7	2.2	1.7	0.5	0.1
Medication: Gliclazide	1.0	1.1	2.9	0.8	0.6	-0.8	-0.8	-1.1	-0.9	-1.6	-1.7	-0.1	-0.5	-1.4	-0.1	-1.5
Illnesses of father: None of the above (group 1)	1.0	1.2	2.2	-0.2	0.5	0.9	0.9	1.0	1.2	1.1	-1.4	0.9	1.5	1.4	1.4	0.9
Smoking status: Current	1.7	2.7	7.0	-2.6	-2.1	1.5	1.3	1.6	1.8	2.2	1.5	-0.7	-0.5	1.1	1.0	2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.7	-0.3	0.1	-0.1	0.0	0.2	-0.2	0.8	0.4	0.1	0.0	0.1	-0.3	0.5
Whole body water mass	0.7	3.9	9.2	0.3	-1.1	2.7	2.8	2.7	2.6	1.7	0.2	-2.0	-0.9	1.3	3.0	1.3
Leg predicted mass (right)	0.3	1.6	4.2	0.6	-0.7	1.7	1.8	1.6	1.5	0.8	-0.0	-1.5	-0.9	0.5	2.0	0.4
Arm fat mass (left)	0.2	0.9	3.6	1.7	1.0	0.4	0.6	0.2	0.4	0.2	-1.9	-0.9	0.3	0.1	0.9	-1.4
Number of self-reported non-cancer illnesses	1.8	3.2	6.8	2.6	1.9	-1.5	-1.5	-1.9	-2.1	-1.9	-2.3	0.6	1.5	-0.3	-1.1	-2.5
Average weekly champagne plus white wine intake	0.1	0.1	1.1	1.0	0.5	-0.0	-0.3	-0.2	-0.1	-0.2	-0.3	0.3	0.2	0.2	-0.1	0.0
Miserableness	1.7	3.0	7.0	1.1	1.8	-1.8	-1.9	-2.2	-2.6	-1.9	-0.5	0.2	0.6	-1.1	-2.1	-2.4
Guilty feelings	0.2	0.3	0.7	-0.5	-0.4	0.4	0.5	0.5	0.0	0.8	0.7	-0.9	0.3	0.6	0.5	0.5
Wears glasses or contact lenses	0.6	0.6	3.4	1.8	1.2	0.3	0.6	0.2	-0.1	0.1	-0.9	-0.6	0.6	0.4	0.4	-1.0
Ever taken oral contraceptive pill	1.4	1.6	5.9	-2.4	-1.4	0.8	0.8	1.1	1.1	1.2	1.7	0.0	-0.5	0.6	0.7	1.8
Hearing aid user	2.2	2.5	5.8	1.1	1.3	-1.6	-1.7	-1.9	-1.5	-2.1	-2.2	-0.2	0.2	-1.0	-2.4	-1.6
Mother’s age at death	0.7	0.8	2.7	0.9	1.7	-0.7	-0.5	-0.7	-0.3	-0.9	-0.9	1.6	0.5	-0.6	-0.6	-0.9
Financial situation satisfaction	0.5	0.6	1.3	0.7	1.1	-0.7	-0.6	-0.7	-1.0	-1.0	-0.8	0.1	0.6	0.1	-0.7	-0.9
Tinnitus: Yes, now most or all of the time	2.5	2.9	5.4	2.2	1.1	-1.8	-1.7	-2.0	-1.5	-2.3	-1.6	1.3	-0.0	-1.7	-1.5	-2.1
Commuting to job workplace: Public transport	0.9	1.1	4.2	-1.0	-1.3	0.5	0.4	0.9	0.8	1.1	2.0	0.6	-0.6	0.3	0.2	2.0
Eye problems/disorders: Glaucoma	0.4	0.5	2.6	-0.0	1.6	-0.2	-0.3	-0.2	-0.4	0.1	-0.5	1.5	1.1	0.4	-0.4	-0.0
Medication: Blood pressure	0.3	0.5	1.8	1.3	-0.1	-0.8	-0.7	-0.7	-0.6	-0.8	-0.6	-0.4	-0.8	-0.9	-0.0	-0.8
Pain type(s) experienced in last month: Hip pain	5.3	6.7	13.8	-0.4	0.2	3.5	3.6	3.4	3.1	3.0	0.4	-1.9	1.3	3.2	3.7	1.3
Supplements: Fish oil (including cod liver oil)	1.1	1.4	3.2	-0.3	-0.1	1.7	1.7	1.6	1.5	1.6	0.3	-0.2	0.4	1.1	1.8	0.6
High cholesterol (Self-reported)	1.9	3.3	7.2	0.7	0.6	-2.5	-2.7	-2.5	-2.7	-1.9	0.1	1.5	0.2	-1.5	-2.5	-1.1
Medication: Bendroflumethiazide	0.6	0.9	2.4	1.3	1.6	-0.5	-0.4	-0.5	-1.0	0.3	-1.5	-0.7	1.3	0.9	0.2	-0.6
Medication: Paracetamol	0.4	0.6	1.3	-0.0	0.2	-0.8	-0.7	-0.6	-1.0	-0.9	1.2	0.7	1.2	0.4	-0.9	-0.2
Medication: Lisinopril	1.1	1.5	5.8	1.3	2.4	-0.8	-0.7	-0.7	-0.8	-0.1	-1.6	1.7	1.8	0.6	-0.6	-0.5
Medication: Atorvastatin	1.1	1.3	3.9	1.5	1.6	-0.7	-0.9	-0.6	-0.5	0.0	-1.6	2.0	1.8	0.9	-0.5	0.4
Illnesses of father: High blood pressure	0.4	0.5	2.0	1.4	0.5	-0.7	-0.5	-0.4	-0.8	0.1	1.4	0.6	0.8	0.1	-0.2	-0.2
Alcohol drinker status: Never	0.1	0.1	0.7	-0.1	-0.1	0.1	0.1	0.1	-0.3	0.3	0.9	-0.0	0.1	0.2	-0.4	0.1
Ever smoked	0.8	1.3	6.2	-1.6	-1.8	0.7	0.7	0.8	0.6	0.5	2.5	-0.9	-1.1	0.0	0.4	1.0
Basal metabolic rate	0.5	2.9	7.0	0.4	-1.0	2.3	2.4	2.2	2.2	1.5	0.1	-1.9	-0.9	1.0	2.6	0.9
Leg fat percentage (left)	0.4	1.4	4.7	2.2	2.1	0.2	0.4	0.0	0.1	0.5	-1.8	-0.7	1.2	0.6	0.8	-1.6
Arm fat-free mass (left)	0.9	4.6	10.4	0.3	-0.7	3.0	3.0	2.9	2.9	2.1	0.1	-2.1	-0.4	1.9	3.2	1.3
Number of operations (self-reported)	0.6	0.8	3.9	-0.4	-2.0	-0.8	-0.6	-0.5	-0.5	-0.5	-0.8	-0.4	-1.6	-1.2	-0.6	0.1
Average weekly beer plus cider intake	2.7	3.9	9.4	-0.4	0.4	-3.0	-3.1	-2.8	-2.5	-1.9	0.1	2.2	0.9	-1.4	-2.5	-0.9
Irritability	0.5	0.8	3.2	1.0	1.8	-0.3	-0.2	-0.3	-0.6	0.0	-1.0	0.3	1.7	0.9	0.0	-0.7
Risk taking	2.7	4.0	7.7	-1.7	-1.3	2.6	2.6	2.6	2.7	2.3	0.8	-1.1	-0.3	1.5	2.8	1.6
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.6	-1.1	-0.5	0.6	0.6	0.8	0.8	0.9	1.2	0.6	0.1	0.8	0.3	1.2
Fractured/broken bones in last 5 years	0.3	0.3	1.0	-0.6	-0.3	-0.5	-0.6	-0.5	-0.1	-0.8	-0.2	1.0	-0.6	-0.9	-0.2	-0.2
Age started oral contraceptive pill	1.1	1.4	5.4	2.3	1.3	0.4	0.6	0.4	0.7	-0.4	-2.0	1.8	1.2	0.6	0.9	-0.4
Diastolic blood pressure, automated reading	0.1	0.3	1.3	0.3	-0.0	0.1	0.2	0.3	0.3	1.1	1.0	-0.6	-0.6	-0.2	0.3	0.5
Ever depressed for a whole week	0.7	0.9	1.9	1.3	1.2	0.9	1.0	0.7	0.4	0.2	-1.4	-0.6	0.8	0.6	1.4	-1.0
Unable to work because of sickness or disability	2.3	3.0	6.7	-2.1	-1.7	1.5	1.3	1.8	1.6	2.5	1.9	0.5	0.7	1.8	1.0	2.6
Commuting to job workplace: Cycle	0.2	0.2	0.5	-0.4	0.2	0.4	0.7	0.4	0.7	-0.5	-0.2	-0.6	-0.2	0.0	0.6	-0.4
Myopia	0.2	0.3	2.2	1.5	0.2	-0.1	-0.3	-0.4	-0.6	-0.1	0.4	-0.9	0.2	0.4	-0.3	-0.4
Vascular/heart problems diagnosed by doctor	1.0	2.8	9.7	-3.1	-2.9	0.8	0.8	1.1	1.4	0.3	1.6	-0.0	-2.7	-1.3	0.2	1.6
Cholesterol lowering medication	1.0	1.4	3.3	0.9	0.3	-1.2	-1.2	-1.5	-1.3	-1.8	-0.8	-0.3	-0.8	-1.5	-1.0	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.9	0.1	0.2	-0.6	-0.6	-0.8	-1.0	-1.4	0.1	-0.9	-0.3	-0.4	-1.1	-1.2
Pain experienced in last month	0.8	1.4	5.7	-0.8	-1.0	-1.1	-1.1	-1.1	-0.6	-0.9	-0.3	0.8	-2.1	-2.4	-1.1	-0.2
Supplements: Calcium	0.2	0.2	0.6	-0.7	-0.2	0.2	0.1	0.3	0.2	0.2	0.8	0.2	0.3	0.4	-0.3	0.7
Basal cell carcinoma (self-reported)	0.8	0.9	2.1	1.5	0.6	-0.9	-1.2	-1.1	-1.2	-1.4	-0.5	0.1	0.3	-0.4	-1.2	-0.7
Heart attack/myocardial infarction (self-reported)	2.0	2.5	11.3	1.7	3.0	-0.1	-0.2	-0.5	-0.6	-0.3	-1.7	-0.0	3.4	2.1	-0.1	-1.4
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	4.9	2.0	1.5	-1.1	-1.1	-1.5	-1.2	-1.8	-2.2	-1.4	-0.2	-0.9	-1.3	-2.1
Heart disease (siblings)	0.1	0.1	0.5	-0.7	0.3	0.3	0.1	0.1	0.6	-0.3	0.0	-0.1	0.0	0.2	0.1	0.1
Alcohol drinker status: Previous	1.5	1.7	3.9	-2.0	-1.8	1.1	1.1	1.4	1.6	1.8	0.7	0.1	-0.9	0.4	0.4	2.0
Pack years of smoking	0.5	0.8	2.1	0.2	1.0	0.9	0.9	0.8	0.6	1.1	-0.7	-0.2	1.2	1.4	1.2	0.1
Impedance of whole body	1.5	7.7	17.2	-3.0	-2.1	-3.3	-3.5	-3.0	-2.5	-2.1	2.4	2.5	-2.1	-3.3	-4.2	0.1
Leg fat mass (left)	0.3	1.0	3.0	1.7	1.2	0.7	0.8	0.5	0.5	0.7	-1.5	-0.8	0.8	0.8	1.2	-1.0
Arm predicted mass (left)	1.0	4.8	10.8	0.4	-0.6	3.0	3.0	3.0	3.0	2.3	-0.1	-2.1	-0.4	1.9	3.3	1.4