Best TWAS P=6.58e-12 · Best GWAS P=1.55e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ARFRP1 | 0.07 | 0.07 | lasso | 3 | 0.06 | 5.3e-08 | -4.9 | 5.2 | 2.6e-07 | -0.56 | 0.93 | 0.07 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | STMN3 | 0.07 | 0.02 | lasso | 4 | 0.05 | 2.8e-06 | -5.0 | -5.5 | 4.2e-08 | 0.51 | 0.75 | 0.21 | FALSE |
| 3 | GTEx | Brain Cerebellum | STMN3 | 0.33 | 0.12 | lasso | 10 | 0.20 | 1.8e-06 | -4.9 | -5.3 | 1.5e-07 | 0.51 | 0.71 | 0.07 | FALSE |
| 4 | METSIM | Adipose | STMN3 | 0.20 | 0.08 | enet | 30 | 0.11 | 1.0e-16 | -5.9 | 5.6 | 1.9e-08 | -0.39 | 0.18 | 0.82 | TRUE |
| 5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LIME1 | 0.08 | 0.07 | lasso | 4 | 0.06 | 2.0e-04 | -6.7 | 6.9 | 6.6e-12 | -0.97 | 0.00 | 1.00 | TRUE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | TNFRSF6B | 0.02 | 0.01 | enet | 7 | 0.01 | 6.9e-03 | -4.8 | -5.2 | 1.7e-07 | 0.61 | 0.11 | 0.24 | FALSE |
| 7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RTEL1 | 0.05 | 0.04 | blup | 56 | 0.03 | 4.2e-03 | -5.3 | -6.3 | 2.3e-10 | 0.57 | 0.05 | 0.15 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LIME1 | 0.04 | 0.05 | blup | 47 | 0.05 | 9.0e-06 | -4.9 | -5.7 | 1.1e-08 | 0.56 | 0.68 | 0.26 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZGPAT | 0.05 | 0.06 | lasso | 3 | 0.06 | 5.5e-07 | -5.0 | 5.1 | 2.7e-07 | -0.61 | 0.96 | 0.03 | FALSE |
| 10 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | LIME1 | 0.10 | 0.02 | blup | 47 | 0.04 | 1.5e-02 | -5.0 | -6.1 | 1.3e-09 | 0.60 | 0.02 | 0.27 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | LIME1 | 0.05 | 0.03 | blup | 47 | 0.04 | 3.9e-05 | -4.8 | -6.0 | 2.0e-09 | 0.63 | 0.25 | 0.67 | FALSE |