Best TWAS P=3.05e-10 · Best GWAS P=8.76e-12 conditioned to 0.000883
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cerebellum | KLHL3 | 0.14 | 0.04 | enet | 19 | 0.08 | 2.8e-03 | 5.0 | 6.3 | 3.0e-10 | 0.71 | 0.03 | 0.82 | TRUE |
2 | GTEx | Ovary | KDM3B | 0.21 | 0.01 | lasso | 3 | -0.01 | 4.9e-01 | 5.5 | 5.3 | 1.5e-07 | 0.72 | 0.03 | 0.63 | FALSE |
3 | GTEx | Testis | CDC23 | 0.10 | 0.07 | enet | 10 | 0.07 | 6.1e-04 | 4.9 | 6.0 | 1.9e-09 | 0.56 | 0.52 | 0.15 | FALSE |
4 | NTR | Blood | KLHL3 | 0.02 | 0.01 | bslmm | 437 | 0.01 | 1.9e-04 | -5.2 | 5.3 | 1.1e-07 | 0.44 | 0.19 | 0.22 | FALSE |
5 | ROSMAP | Brain Pre-frontal Cortex | SPOCK1 | 0.10 | 0.01 | blup | 629 | 0.04 | 3.4e-06 | -4.1 | 5.7 | 9.6e-09 | 0.34 | 0.46 | 0.03 | FALSE |
6 | YFS | Blood | CDC23 | 0.01 | 0.01 | lasso | 2 | 0.01 | 3.1e-03 | 4.9 | -5.4 | 7.5e-08 | -0.49 | 0.25 | 0.26 | FALSE |
7 | YFS | Blood | FAM13B | 0.06 | 0.08 | lasso | 21 | 0.09 | 5.3e-29 | -6.0 | -5.3 | 1.0e-07 | -0.74 | 0.16 | 0.84 | FALSE |
8 | The Cancer Genome Atlas | Lung Adenocarcinoma | GFRA3 | 0.02 | 0.01 | lasso | 2 | 0.01 | 2.2e-02 | -5.1 | 5.2 | 1.7e-07 | 0.55 | 0.02 | 0.77 | FALSE |
9 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FAM53C | 0.11 | 0.02 | blup | 34 | 0.06 | 2.8e-03 | -4.9 | -5.6 | 2.3e-08 | -0.52 | 0.01 | 0.58 | FALSE |
10 | The Cancer Genome Atlas | Thyroid Carcinoma | CDC25C | 0.03 | 0.01 | lasso | 8 | 0.02 | 6.5e-03 | 5.7 | -6.1 | 1.1e-09 | -0.43 | 0.00 | 0.90 | FALSE |