Hub : Genes

KLHL3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.1400	0.0650	9.4e-03	0.039	NA	0.077	NA	0.066	2.7e-02	NA	2.8e-03	NA	5.3e-03
2	NTR	Blood	0.0231	0.0095	6.2e-04	0.008	0.009	0.008	0.010	0.009	1.0e-03	3.4e-04	7.4e-04	1.9e-04	4.4e-04
3	YFS	Blood	0.0609	0.0156	1.6e-14	0.055	0.058	0.060	0.059	0.059	1.8e-17	2.6e-18	6.7e-19	1.1e-18	1.6e-18
4	TCGA	Testicular Germ Cell Tumors	0.1430	0.0700	5.5e-03	0.026	0.030	0.009	NA	0.006	4.3e-02	3.1e-02	1.5e-01	NA	1.9e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.8	1.3	-1.0	-1.1	0.9	-0.1
Bipolar Disorder or Schizophrenia	0.7	1.8	4.7	-0.6	0.1	2.2	-1.5
Depressed Affect (Nagel 2018)	1.7	3.6	10.4	3.2	0.9	1.5	-0.9
Depression (Nagel 2018)	3.2	4.8	10.2	3.2	1.7	2.1	-1.4
Intelligence (Savage-Jansen 2018)	2.9	9.0	14.9	-3.9	-3.6	-0.5	2.9
Neuroticism (Nagel 2018)	2.4	5.6	10.5	3.2	0.9	3.0	-1.5
Schizophrenia (2018)	1.0	2.1	4.1	0.1	1.0	2.0	-1.9
Schizophrenia vs Biploar Disorder	3.4	4.5	7.6	1.8	2.8	0.7	-2.5
Worry (Nagel 2018)	1.2	2.5	5.0	2.2	0.2	2.1	-0.7
Alzheimer’s Disease (in mother)	0.8	0.9	1.7	-1.3	-0.6	-0.4	1.2
Alzheimer’s Disease (in father)	0.3	0.3	0.9	1.0	0.6	0.1	0.4
Alzheimer’s Disease (including proxy)	0.6	0.9	2.2	-0.9	-0.7	0.1	1.5
Crohns Disease (2017)	2.8	6.2	12.5	2.7	3.5	-0.2	-2.2
Irritable Bowel Disease (IBD)	1.6	3.9	8.9	1.6	3.0	-0.2	-2.0
Ulcerative Colitis (UC)	0.2	0.4	1.2	0.1	1.1	-0.3	-0.6
Major Depression (MDD)	2.0	2.5	7.0	2.6	0.3	1.5	-0.7
Reaction Time	0.5	1.0	2.2	0.6	1.5	-0.0	-1.3
Verbal and Numeric Reasoning (VNR)	3.4	8.2	13.3	-3.3	-3.6	-1.3	2.6
Breast Cancer	0.8	1.9	5.7	-1.0	-2.4	-0.3	0.8
Ovarian Cancer	0.2	0.3	0.9	-1.0	-0.5	-0.0	-0.2
Prostate Cancer	0.1	0.1	0.2	0.1	0.3	-0.1	0.4
Age at First Birth	1.2	1.7	2.9	-0.9	-0.7	-1.7	1.7
Bipolar Disorder (2011)	0.2	0.2	0.4	-0.5	0.1	0.2	-0.7
Body Mass Index (BMI) (2010)	2.2	3.0	6.2	-0.9	-0.6	-2.5	2.2
Coronary Artery Disease (CAD)	1.7	2.1	3.7	1.9	1.6	0.3	-1.4
Crohns Disease (2012)	1.0	1.6	2.7	1.6	1.6	-0.3	-0.9
Mean Putamen Volume	0.1	0.2	0.3	0.3	-0.0	0.5	-0.6
Fasting Glucose	1.8	2.1	3.4	-1.8	-1.3	-0.6	1.8
HbA1C	1.4	1.5	3.0	-1.7	-0.8	-1.1	1.1
HDL Cholesterol	0.4	0.7	1.2	-0.6	-1.1	0.9	-0.3
LDL Cholesterol	0.5	0.9	2.1	1.4	0.7	0.5	-0.7
Lupus	1.4	2.1	3.3	0.7	1.3	1.7	-1.8
Neuroticism (2016)	1.0	1.4	2.6	1.6	-0.6	1.5	-0.5
Primary Biliary Cirrhosis	0.5	0.7	2.1	-0.6	-0.5	1.4	-0.4
Rheumatoid Arthritis	1.6	2.2	5.1	1.9	2.3	-0.4	-0.3
Schizophrenia (2014)	1.1	2.3	4.9	-0.3	1.0	1.9	-2.2
Triglycerides	0.8	1.3	3.6	1.9	0.1	0.8	-0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.7	0.5	0.8	-0.6	-0.5
Ulcerative Colitis	0.6	0.8	1.2	0.9	1.1	0.4	-1.1
Blood Eosinophil Count	0.8	5.9	10.3	3.2	2.9	-0.7	-2.1
Blood Platelet Count	0.4	4.4	9.2	-2.7	-3.0	1.0	-0.3
Blood Red Count	2.1	20.2	39.7	6.3	5.3	0.6	-3.5
Blood White Count	0.2	1.5	2.4	1.2	1.0	-1.1	-1.5
Heel T-Score	0.4	3.3	7.5	0.7	1.8	1.4	-2.7
BMI	0.9	5.0	13.7	-0.2	-0.7	-3.7	2.4
Height	0.3	6.1	13.3	-2.9	-1.3	-3.6	1.2
Waist Hip Ratio (WHR)	0.4	1.6	4.0	-1.0	-0.2	2.0	-1.1
Systolic Blood Pressure	1.8	9.2	14.6	-3.8	-3.5	-0.2	3.1
Smoking Status	2.6	6.3	11.4	3.4	2.0	2.1	-2.3
Allergy or Eczema	0.8	2.2	4.8	1.4	1.3	-2.2	0.6
Cardiovascular Disease	1.9	6.4	14.9	-2.4	-1.2	-1.9	3.9
Hypothyroidism (self reported)	0.6	1.3	2.9	1.0	1.7	1.2	-0.0
Respiratory disease	0.7	1.6	5.9	0.6	0.2	-2.4	0.3
Type 2 Diabetes (T2D) (2018)	2.7	5.1	15.6	-0.9	-0.4	-4.0	2.0
Lung FEV1/FVC ratio	1.8	8.9	15.7	-3.4	-4.0	-1.2	2.6
Lung FVC	0.3	1.3	2.1	0.5	0.8	1.4	-1.4
Neuroticism	3.4	8.3	19.4	4.4	1.3	3.0	-1.6
Chronotype (morning person)	0.4	0.9	1.8	-0.6	-1.1	1.4	-0.5
Hair Pigment	0.1	1.4	4.7	0.1	-0.3	1.0	-2.2
Tanning	0.1	1.8	2.1	-1.4	-1.4	-1.4	1.1
Hand grip strength (left)	0.1	0.2	0.5	-0.3	-0.1	-0.7	0.4
Number of treatments/medications taken	0.9	1.7	4.7	2.2	1.1	-0.7	0.5
Average weekly spirits intake	1.6	1.9	4.3	-1.6	-2.1	0.8	-0.5
Sensitivity / hurt feelings	2.5	4.2	7.4	2.7	1.6	1.6	-2.0
Frequency of depressed mood in last 2 weeks	1.8	2.5	6.4	2.5	0.9	1.4	-1.1
Hearing difficulty/problems: Yes	0.2	0.3	0.8	-0.6	0.4	-0.9	0.2
Relative age of first facial hair	3.6	7.5	12.5	2.5	1.2	3.5	-3.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.4	-1.5	-1.0	-1.0	0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.0	0.0	0.4	0.5	1.0
Ever had hysterectomy (womb removed)	0.5	0.5	0.9	-0.9	-0.3	-0.6	0.9
Systolic blood pressure, automated reading	3.1	8.9	12.3	-3.5	-3.2	-1.8	3.2
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	-0.3	-0.2	-0.5	0.3
Angina	1.7	2.2	4.7	2.2	1.9	0.1	-0.7
Medication for hormone replacement therapy	1.3	1.4	3.4	-1.8	-0.9	-1.2	0.0
Vitamin and mineral supplements	2.8	3.8	8.6	2.3	2.9	0.2	-1.0
Supplements: Zinc	2.8	3.1	5.4	-1.9	-2.3	0.2	1.8
Medication: Co-codamol	1.5	1.7	3.8	1.2	1.1	1.9	-0.6
Medication: Metformin	1.5	2.1	6.8	-0.3	-0.6	-2.6	1.2
Diabetes (father)	1.3	1.6	3.0	-0.8	-1.1	-1.3	1.7
Diabetes (mother)	0.4	0.6	1.9	0.1	1.4	-0.5	-0.1
Severe depression (siblings)	1.5	1.7	2.3	-1.5	-1.1	-1.2	1.4
Pack years adult smoking proportion	1.7	2.6	4.4	1.6	1.3	2.1	-1.3
Impedance of leg (right)	1.1	5.5	11.9	0.9	0.3	3.5	-3.0
Leg fat-free mass (left)	1.7	9.2	23.7	-1.3	-0.8	-4.9	3.3
Trunk fat percentage	0.5	2.2	6.8	-0.2	-0.8	-2.6	1.1
Hand grip strength (right)	0.4	1.1	1.9	-0.8	-0.9	-1.4	1.0
Townsend deprivation index at recruitment	0.6	0.9	2.3	0.9	0.4	-1.5	-0.6
Current tobacco smoking	2.0	3.2	5.0	2.0	0.9	2.2	-1.8
Average weekly fortified wine intake	0.5	0.6	2.3	0.3	0.1	-1.5	0.2
Maternal smoking around birth	3.7	5.4	7.6	2.3	2.8	1.5	-2.5
Fed-up feelings	1.1	2.0	5.5	2.4	1.1	1.0	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.6	5.4	2.3	1.9	-0.0	-1.1
Relative age voice broke	0.7	1.0	2.0	0.4	-0.2	1.4	-1.4
Taking other prescription medications	0.3	0.5	1.2	0.8	1.1	-0.2	0.0
Age when periods started (menarche)	1.3	3.2	10.0	0.9	0.6	1.3	-3.2
Bilateral oophorectomy (both ovaries removed)	2.5	2.8	7.1	-1.9	-0.1	-2.7	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.0	0.6	1.7	-0.6	-1.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	0.8	0.1	-0.2	0.2
Qualifications: CSEs or equivalent	1.0	1.3	2.7	1.5	1.7	0.4	-0.2
Serious illness, injury or assault to yourself	0.6	0.7	1.3	-1.1	-0.5	-1.1	0.3
High blood pressure	2.6	7.2	13.8	-1.6	-1.0	-3.4	3.7
Hayfever, allergic rhinitis or eczema	1.0	2.2	3.6	1.7	1.4	-1.9	0.5
Multivitamins +/- minerals	4.7	5.9	10.9	-2.8	-3.3	-1.2	1.8
Stomach or abdominal pain in last month	0.2	0.3	0.6	-0.1	-0.8	-0.1	0.6
Supplements: Glucosamine	0.2	0.3	0.7	0.9	-0.3	-0.4	0.2
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.7	1.2	1.3	0.4	-0.5
Medication: Atenolol	0.9	1.2	3.0	-1.2	-0.3	-0.3	1.7
Medication: Levothyroxine sodium	0.4	0.8	2.1	-0.0	0.3	-1.4	0.9
Sitting height	0.9	6.1	9.2	-2.3	-1.3	-3.0	2.8
Chronic bronchitis/emphysema (father)	0.4	0.5	1.6	0.4	-0.1	1.3	-0.2
High blood pressure (mother)	1.8	2.5	4.9	-1.3	-0.5	-1.8	2.2
Body mass index (BMI)	1.3	5.4	14.7	-0.2	-0.2	-3.8	2.6
Impedance of leg (left)	1.2	5.8	13.8	0.5	0.2	3.7	-3.0
Leg predicted mass (left)	1.7	9.2	23.8	-1.4	-0.8	-4.9	3.2
Trunk fat mass	1.1	4.6	12.7	-0.7	-1.2	-3.6	2.0
Waist circumference	0.7	2.5	7.9	-0.3	-0.4	-2.8	1.4
Number of incorrect matches in round	2.1	3.5	6.8	2.6	2.2	-0.8	-1.2
Past tobacco smoking	0.8	1.5	4.3	-2.1	-1.1	-0.4	0.4
Alcohol usually taken with meals	0.4	0.7	1.2	-0.5	-1.0	-1.1	0.2
Nervous feelings	2.1	4.0	6.3	2.5	0.7	2.4	-1.8
Frequency of tenseness / restlessness in last 2 weeks	1.9	2.9	7.6	2.7	1.8	-0.8	-0.5
Hearing difficulty/problems with background noise	0.8	1.2	3.1	0.7	0.9	-1.8	0.7
Hair/balding pattern: Pattern 2	0.6	0.7	2.2	-0.8	0.2	0.1	1.5
Had menopause	0.4	0.5	1.3	-0.8	-0.3	0.1	1.2
Had other major operations	2.0	2.5	3.1	-1.6	-1.3	-1.7	1.8
Forced vital capacity (FVC)	0.2	0.9	2.7	-1.6	0.0	-0.9	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.1	-0.0	1.2	-1.4	-0.2
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.3	1.5	-1.0	-0.3	0.6
Qualifications: None of the above	5.3	11.4	20.9	4.0	4.6	1.6	-2.5
Financial difficulties in last 2 years	2.6	3.5	4.9	-2.2	-1.8	-1.1	2.2
Mouth/teeth dental problems	2.1	3.3	5.6	-2.4	-1.7	-0.8	2.0
Heart attack	3.0	3.8	7.6	2.1	2.8	0.4	-1.7
Allergy	0.9	2.2	3.7	-1.9	-1.5	1.7	0.3
Pain all over the body in last month	0.8	0.8	1.6	1.3	0.9	1.0	0.1
Diabetes (self-reported)	1.5	2.3	7.4	-0.7	0.3	-2.7	1.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	0.9	0.6	-1.0	0.1
Medication: Ramipril	2.2	2.8	6.1	0.1	1.6	-2.5	1.6
Medication: Simvastatin	0.8	1.1	2.7	0.3	1.1	-1.6	0.8
Fluid intelligence score	3.1	6.5	10.9	-3.3	-3.1	-1.5	1.8
Illnesses of siblings	1.3	1.8	2.7	1.3	0.6	1.5	-1.6
Neuroticism score	2.4	5.0	11.7	3.4	0.7	2.3	-1.5
Weight	1.6	8.1	21.7	-1.2	-0.9	-4.7	2.9
Impedance of arm (right)	0.9	4.2	8.8	0.4	-0.1	2.8	-3.0
Arm fat percentage (right)	0.7	2.9	8.7	-0.1	-0.7	-3.0	1.5
Trunk fat-free mass	1.7	9.8	22.6	-1.7	-0.9	-4.8	3.6
Hip circumference	1.2	5.2	17.3	-0.5	-0.6	-4.2	1.7
Time employed in main current job	0.1	0.1	0.3	0.2	-0.5	-0.3	-0.2
Alcohol intake versus 10 years previously	0.1	0.2	0.7	0.2	0.8	-0.3	-0.0
Father’s age at death	3.2	4.4	14.7	-1.2	-3.8	-0.0	1.1
Worrier / anxious feelings	2.0	3.8	5.2	2.3	1.9	1.9	-1.7
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.2	0.8	0.8	1.0	-1.1
Falls in the last year	0.9	1.2	2.3	-0.7	-0.5	-1.5	1.3
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.5	-0.2	0.7	-0.2
Number of live births	2.9	4.1	7.4	1.6	1.8	2.7	-1.7
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	6.7	-2.6	-0.9	-1.6	0.9
Pulse rate	5.3	9.0	15.4	-3.9	-3.7	-1.8	1.9
Happiness	2.4	2.9	6.3	2.5	1.8	1.1	-0.7
Noisy workplace	2.0	2.5	3.1	1.7	1.8	1.1	-1.7
Qualifications: A levels/AS levels or equivalent	4.1	9.1	11.4	-3.4	-3.2	-2.6	2.8
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.6	-1.5	-1.6	-0.6	0.6
Mouth/teeth dental problems: Dentures	4.2	7.1	13.3	3.6	3.3	-0.9	-1.9
Asthma	0.6	1.2	3.1	1.0	0.0	-1.8	0.7
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	1.8	1.4	-0.4	1.3	-1.1
Medication: Cholesterol lowering	0.3	0.4	0.8	-0.4	0.1	-0.9	0.8
Depression (self-reported)	2.3	2.7	6.5	1.7	-0.2	2.5	-1.2
Medication: Lansoprazole	0.3	0.4	1.3	1.1	0.3	-0.2	0.1
Prospective memory result	0.5	0.6	1.0	0.3	0.7	0.9	-1.0
Lung cancer (father)	0.4	0.5	1.1	-0.6	0.1	-1.1	0.7
Illnesses of mother	0.5	0.6	1.1	-1.0	-1.0	0.4	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.4	-1.6	-0.1	-1.4	0.5
Pulse wave Arterial Stiffness index	1.3	1.5	2.2	-1.5	-0.3	-1.4	1.4
Impedance of arm (left)	1.0	4.5	10.1	0.6	0.2	2.8	-3.2
Arm fat mass (right)	1.3	5.3	15.0	-0.5	-0.6	-3.9	2.4
Trunk predicted mass	1.7	9.8	22.8	-1.7	-1.0	-4.8	3.6
Standing height	0.4	3.8	6.0	-2.2	-1.6	-2.4	1.3
Length of working week for main job	1.8	2.0	5.5	-0.9	-2.3	-0.7	1.2
Exposure to tobacco smoke at home	0.6	0.6	1.1	-0.7	-0.5	1.1	-0.8
Breastfed as a baby	0.4	0.5	0.7	-0.1	-0.8	-0.8	0.8
Tense / ‘highly strung’	2.1	3.4	6.4	2.5	0.9	2.2	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.4	1.2	-0.8	0.5	-0.6
Hair/balding pattern: Pattern 4	1.2	3.0	9.5	-0.6	-0.4	-3.1	1.3
Birth weight of first child	0.3	0.5	1.7	-0.2	-0.3	-0.4	-1.3
Peak expiratory flow (PEF)	1.6	3.7	7.5	-2.1	-0.8	-2.7	1.5
Pulse wave reflection index	1.5	1.8	3.5	1.5	1.9	0.2	-1.3
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.7	0.6	-0.2	0.8	-0.5
Loud music exposure frequency	0.8	0.9	2.9	-0.1	-0.2	1.7	0.8
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	5.7	-2.4	-2.3	-0.3	1.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.7	0.8	0.1	0.8	-0.8
Blood clot in the leg (DVT)	0.3	0.4	0.8	0.9	0.3	-0.8	0.1
Medication: Paracetamol	1.0	1.7	3.7	1.9	1.7	-0.4	-0.5
Headache pain in last month	0.1	0.2	0.7	-0.4	-0.9	0.1	0.3
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	4.7	1.3	0.8	1.6	-2.2
Glaucoma (self-reported)	0.3	0.3	1.1	0.1	-1.1	0.2	0.1
Gout (self-reported)	1.7	2.4	5.5	0.7	0.1	1.9	-2.3
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.4	1.2	1.5	0.9	-0.1
Medication: Amlodipine	0.5	0.7	2.2	-0.4	-0.5	0.4	1.5
Medication: Ventolin 100micrograms inhaler	1.4	1.8	5.8	1.1	-0.1	-2.4	-0.1
Birth weight	1.4	2.9	7.1	1.5	1.1	1.1	-2.7
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.0	-0.2	-0.2	-1.4	1.0
High blood pressure (siblings)	1.4	2.1	3.9	-2.0	-0.8	-0.7	1.8
Forced vital capacity (FVC), Best measure	0.1	0.4	0.6	-0.4	0.8	-0.7	-0.6
Body fat percentage	0.5	2.1	7.0	0.1	-0.6	-2.6	1.1
Leg fat percentage (right)	0.5	1.7	5.2	0.7	-0.4	-2.3	1.0
Arm fat-free mass (right)	1.8	9.1	22.3	-1.5	-0.6	-4.7	3.4
Exposure to tobacco smoke outside home	0.3	0.4	1.0	-1.0	-0.3	-0.6	-0.4
Comparative body size at age 10	1.5	4.2	8.2	-1.6	-1.2	-2.9	2.1
Number of full brothers	0.4	0.5	1.9	1.4	0.5	-0.1	0.0
Worry too long after embarrassment	1.4	2.4	5.7	1.5	-0.7	2.4	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.1	1.8	0.1	1.5	-1.4
Wheeze or whistling in the chest in last year	0.7	1.3	4.5	0.5	0.3	-2.1	0.6
Number of children fathered	2.2	2.5	4.9	2.2	1.4	1.7	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	0.0	0.2	-0.3	0.4
Age at first live birth	0.2	0.4	0.6	-0.1	-0.7	-0.7	-0.7
Pulse wave peak to peak time	1.1	1.3	1.8	1.2	0.3	1.3	-1.3
Health satisfaction	0.9	1.2	4.7	2.2	0.4	-0.1	0.1
Shortness of breath walking on level ground	0.7	0.8	1.5	-0.8	-1.2	-0.8	0.8
Qualifications: College or University degree	1.3	4.0	6.6	-2.6	-2.4	-1.4	1.3
Eye problems/disorders: None of the above	2.6	3.0	5.1	-2.2	-1.4	-0.7	2.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.6	0.1	0.3	-0.8	-0.5
Emphysema/chronic bronchitis	3.3	3.7	5.4	2.3	0.9	1.8	-2.3
Medication for pain relief, constipation, heartburn	1.0	1.8	5.1	-2.2	-1.4	0.1	-0.3
Neck or shoulder pain in last month	0.3	0.5	1.8	0.2	0.1	1.3	-0.2
Medication: Blood pressure	1.9	3.4	6.7	-1.0	-1.1	-2.6	2.1
Angina (self-reported)	1.6	2.1	4.6	2.1	1.9	0.2	-0.7
Migraine (self-reported)	0.5	0.6	1.1	-0.7	-1.0	1.0	-0.1
Medication: Ibuprofen	0.5	0.6	1.0	1.0	-0.6	1.0	-0.4
Medication: Allopurinol	1.5	2.0	4.4	0.6	0.5	1.8	-2.1
Medication: Omeprazole	1.3	1.5	4.3	2.1	1.2	-0.1	0.5
Medication: Seretide 50 evohaler	0.2	0.2	0.6	0.2	-0.4	-0.3	0.8
Mean time to correctly identify matches	1.0	1.8	3.7	1.1	1.9	0.2	-1.6
Heart disease (mother)	1.2	1.5	3.3	1.3	1.8	0.5	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.9	3.5	7.0	2.6	1.1	2.2	-0.9
Whole body fat mass	1.2	5.1	14.8	-0.5	-0.8	-3.8	2.2
Leg fat mass (right)	1.0	4.0	11.1	-0.3	-0.7	-3.3	2.1
Arm predicted mass (right)	1.7	8.6	21.2	-1.4	-0.6	-4.6	3.3
Pulse rate, automated reading	11.7	37.8	70.0	-8.4	-7.8	-3.4	3.0
Alcohol intake frequency.	2.0	4.5	7.3	2.4	1.9	1.3	-2.7
Comparative height size at age 10	1.3	7.4	21.4	-2.0	-0.6	-4.6	2.0
Number of full sisters	3.1	3.8	5.8	1.7	1.5	2.4	-2.0
Suffer from ‘nerves’	1.1	1.7	4.2	2.0	0.1	1.5	-0.5
Overall health rating	0.8	1.6	3.8	2.0	1.6	0.1	-0.5
Chest pain or discomfort	0.8	1.2	2.5	-0.2	-0.6	-1.6	1.4
Had major operations	0.9	1.0	2.8	1.0	-1.7	0.5	-0.2
Age at last live birth	0.3	0.4	1.2	0.5	0.4	0.1	-1.1
Family relationship satisfaction	3.4	4.1	6.6	2.3	2.6	1.5	-1.5
Leg pain on walking	1.2	1.5	3.6	1.9	1.5	0.2	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.4	0.6	-0.4	0.0	-0.1
Commuting to job workplace: Car/motor vehicle	1.0	1.1	4.3	0.0	2.1	-0.3	-0.3
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	4.8	1.9	2.2	0.7	-1.3
Medication: Aspirin	0.1	0.2	0.5	0.5	-0.1	-0.7	-0.2
Supplements: Vitamin C	2.4	2.9	6.8	-1.1	-2.6	1.8	-0.4
Knee pain experienced in last month	0.5	0.7	1.0	-0.6	-1.0	-0.8	1.0
Hypertension (Self-reported)	2.5	7.0	12.9	-1.6	-0.9	-3.6	3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.4	7.0	2.6	1.0	1.2	-0.4
Illnesses of father: Heart disease	0.3	0.4	1.2	-1.1	0.4	-0.4	0.3
Illnesses of siblings: Diabetes	3.6	4.4	7.9	-1.9	-0.9	-2.8	2.3
Smoking status: Previous	0.3	0.5	0.8	0.9	0.7	-0.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.6	0.5	-0.8	-0.0	0.2
Whole body fat-free mass	1.8	10.2	24.1	-1.7	-1.0	-4.9	3.6
Leg fat-free mass (right)	1.7	8.9	21.2	-1.7	-1.0	-4.6	3.2
Arm fat percentage (left)	0.7	2.7	8.8	0.0	-0.4	-3.0	1.3
Average weekly red wine intake	1.0	1.4	3.8	-0.8	-1.9	-0.7	0.9
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.0	0.1	-0.1	0.2	-0.1
Mood swings	0.5	1.0	2.7	1.6	0.0	1.1	-0.0
Loneliness, isolation	2.5	3.4	7.3	2.7	1.9	0.7	-1.5
Long-standing illness, disability or infirmity	0.8	1.2	2.8	1.2	0.2	-1.7	0.7
Ever had bowel cancer screening	1.4	1.7	3.6	1.9	1.1	0.6	-1.2
Diabetes diagnosed by doctor	1.7	2.8	8.9	-0.6	0.3	-3.0	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	0.1	0.3	-0.1	-0.3
Friendships satisfaction	2.9	3.6	5.6	2.4	2.3	1.3	-1.4
Qualifications: nursing, teaching	3.9	6.0	9.3	-2.8	-3.0	-1.1	2.5
Commuting to job workplace: Walk	5.0	5.4	7.5	-2.4	-2.7	-2.4	1.5
Eye problems/disorders: Cataract	3.9	4.5	10.2	3.2	2.6	-0.1	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	-0.2	0.4	0.9	-0.5
Medication for cholesterol	1.3	2.0	4.4	0.1	-1.6	2.1	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.6	0.2	1.3	0.1	-0.2
Back pain experienced in last month	0.3	0.5	1.8	-0.1	1.3	0.2	0.4
Mineral and other dietary supplements	0.6	0.8	2.2	-1.5	-0.1	-0.7	0.8
Breast cancer (self-reported)	0.4	0.5	1.1	-1.1	0.2	-0.4	0.8
Asthma (self-reported)	0.7	1.4	3.8	1.1	0.1	-1.9	0.7
Osteoporosis (self-reported)	1.4	1.7	3.7	0.8	1.4	0.9	-1.9
Osteoarthritis (self-reported)	0.4	0.5	1.8	-0.1	1.4	-0.4	-0.1
Medication: Aspirin	0.2	0.3	0.4	0.6	-0.0	-0.7	-0.5
Medication: Gliclazide	2.0	2.3	4.9	-2.2	-0.7	-1.7	0.9
Illnesses of father: None of the above (group 1)	0.1	0.2	0.3	0.3	-0.5	-0.4	-0.4
Smoking status: Current	2.1	3.4	4.9	2.1	0.9	2.2	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	2.9	-1.5	-0.7	-1.7	0.9
Whole body water mass	1.8	10.0	23.3	-1.7	-1.0	-4.8	3.6
Leg predicted mass (right)	1.7	9.1	22.0	-1.7	-1.0	-4.7	3.3
Arm fat mass (left)	1.4	5.8	16.2	-0.7	-0.6	-4.0	2.5
Number of self-reported non-cancer illnesses	0.3	0.5	0.8	0.7	0.2	-0.7	0.9
Average weekly champagne plus white wine intake	0.6	0.8	3.0	0.1	-1.7	-0.3	-0.1
Miserableness	1.9	3.4	11.4	3.4	1.4	-0.1	-0.4
Guilty feelings	0.3	0.4	0.8	0.7	-0.1	0.9	-0.5
Wears glasses or contact lenses	0.9	1.0	3.4	0.2	0.6	-1.8	0.4
Ever taken oral contraceptive pill	1.5	1.7	2.1	-1.3	-1.3	-1.2	1.4
Hearing aid user	0.1	0.1	0.3	-0.0	0.4	-0.5	-0.1
Mother’s age at death	5.3	6.7	9.7	-3.1	-2.6	-1.4	2.8
Financial situation satisfaction	0.4	0.5	1.3	-0.2	-0.4	-0.6	1.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.4	0.2	0.3	0.4
Commuting to job workplace: Public transport	3.1	3.7	5.4	-1.9	-2.3	-1.9	1.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	0.4	-0.3	0.5	-0.6
Medication: Blood pressure	1.3	2.5	4.7	0.4	1.2	-1.9	2.2
Pain type(s) experienced in last month: Hip pain	2.2	2.8	5.6	1.4	2.4	1.4	-1.3
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.6	-0.2	-0.8	0.6	-0.1
High cholesterol (Self-reported)	0.2	0.4	0.6	0.3	0.7	0.8	0.7
Medication: Bendroflumethiazide	0.5	0.7	1.5	-0.4	-1.1	-0.1	1.2
Medication: Paracetamol	0.7	1.1	3.4	1.8	0.8	-0.4	-0.5
Medication: Lisinopril	0.7	1.0	1.2	-1.1	-0.7	-1.1	1.0
Medication: Atorvastatin	0.5	0.6	1.1	-0.5	-1.1	0.3	1.0
Illnesses of father: High blood pressure	2.8	3.5	4.8	-2.1	-1.1	-1.9	2.2
Alcohol drinker status: Never	0.2	0.2	0.5	-0.7	-0.6	0.3	-0.0
Ever smoked	0.8	1.4	2.7	1.6	0.8	0.8	-1.2
Basal metabolic rate	1.8	10.0	24.5	-1.6	-0.9	-5.0	3.5
Leg fat percentage (left)	0.5	1.7	5.2	0.5	-0.4	-2.3	1.1
Arm fat-free mass (left)	2.1	10.8	25.9	-1.7	-0.8	-5.1	3.7
Number of operations (self-reported)	1.7	2.5	4.0	-0.2	-1.6	-1.9	2.0
Average weekly beer plus cider intake	0.6	0.9	2.1	-0.9	-0.1	0.8	1.5
Irritability	2.6	4.4	7.0	2.2	1.7	2.6	-1.7
Risk taking	2.8	4.0	8.3	-1.4	-2.9	-1.4	1.9
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.8	-0.3	-0.6	-1.7	-0.8
Fractured/broken bones in last 5 years	0.2	0.3	0.8	-0.4	-0.2	-0.9	-0.1
Age started oral contraceptive pill	0.6	0.7	2.0	1.4	0.7	-0.1	-0.7
Diastolic blood pressure, automated reading	2.9	8.9	13.2	-3.6	-3.6	-1.3	2.8
Ever depressed for a whole week	1.3	1.7	3.2	1.4	-1.8	-0.9	0.8
Unable to work because of sickness or disability	1.2	1.5	2.5	1.4	1.1	-0.6	-1.6
Commuting to job workplace: Cycle	0.2	0.2	0.8	-0.2	-0.4	-0.9	0.0
Myopia	1.2	1.7	4.7	0.8	1.2	0.1	-2.2
Vascular/heart problems diagnosed by doctor	1.6	4.3	8.9	0.5	0.0	2.8	-3.0
Cholesterol lowering medication	0.3	0.5	1.4	0.8	1.2	-0.2	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.1	1.7	0.5	-0.3	1.2
Pain experienced in last month	0.1	0.2	0.4	-0.6	-0.2	-0.6	-0.1
Supplements: Calcium	0.5	0.5	1.4	-0.1	-0.7	0.5	-1.2
Basal cell carcinoma (self-reported)	0.5	0.6	1.4	1.2	0.5	0.6	-0.8
Heart attack/myocardial infarction (self-reported)	2.6	3.4	6.8	2.0	2.6	0.4	-1.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.6	1.3	0.3	-0.7	-0.3
Heart disease (siblings)	0.4	0.5	0.8	0.5	0.9	-0.9	0.2
Alcohol drinker status: Previous	2.6	3.0	5.7	1.8	1.1	2.4	-1.4
Pack years of smoking	2.0	2.9	4.0	1.7	1.5	2.0	-1.5
Impedance of whole body	1.3	6.5	13.3	0.6	0.2	3.6	-3.5
Leg fat mass (left)	1.1	4.3	12.1	-0.3	-0.6	-3.5	2.1
Arm predicted mass (left)	1.9	9.6	22.8	-1.6	-0.7	-4.8	3.5