Hub : Genes

FAM13B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.1890	0.0770	0.0012	0.024	NA	0.037	NA	0.015	1.3e-02	NA	2.5e-03	NA	4.1e-02
2	NTR	Blood	0.0110	0.0054	0.0036	0.001	0.006	0.001	0.006	0.003	1.3e-01	3.1e-03	1.1e-01	5.1e-03	4.2e-02
3	YFS	Blood	0.0565	0.0152	0.0000	0.083	0.086	0.091	0.089	0.094	1.1e-25	9.0e-27	2.9e-28	1.4e-27	5.3e-29

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.6	0.8	0.8	-0.9	0.4
Bipolar Disorder or Schizophrenia	1.5	3.6	7.5	1.8	-2.7	-0.5
Depressed Affect (Nagel 2018)	1.1	2.3	5.2	2.3	1.2	0.5
Depression (Nagel 2018)	2.3	3.5	8.5	2.9	-0.9	-1.0
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.2	-0.7	0.7	1.1
Neuroticism (Nagel 2018)	1.5	3.6	10.8	3.3	0.0	0.3
Schizophrenia (2018)	1.9	3.9	7.7	1.9	-2.8	-0.8
Schizophrenia vs Biploar Disorder	2.0	2.7	5.3	-0.9	-2.3	-1.4
Worry (Nagel 2018)	1.5	3.2	9.3	3.0	-0.2	-0.4
Alzheimer’s Disease (in mother)	1.3	1.6	3.7	-1.9	0.1	1.0
Alzheimer’s Disease (in father)	0.7	0.8	2.3	-1.5	0.3	-0.2
Alzheimer’s Disease (including proxy)	1.5	2.2	5.8	-2.4	-0.5	0.7
Crohns Disease (2017)	0.5	1.2	2.5	-0.6	1.6	0.8
Irritable Bowel Disease (IBD)	0.5	1.2	1.7	-1.3	1.2	0.8
Ulcerative Colitis (UC)	0.5	1.0	2.5	-1.6	0.5	0.4
Major Depression (MDD)	0.5	0.6	1.4	1.2	0.6	0.3
Reaction Time	0.5	0.9	1.9	-1.4	-0.7	0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.3	-0.5	1.1	0.5
Breast Cancer	1.5	3.7	5.2	2.3	-1.5	-1.9
Ovarian Cancer	0.8	1.0	1.2	1.0	1.1	0.9
Prostate Cancer	1.2	1.7	2.7	-0.0	1.6	1.6
Age at First Birth	0.4	0.7	1.0	-0.9	0.4	1.0
Bipolar Disorder (2011)	0.3	0.3	0.9	0.3	-0.9	-0.0
Body Mass Index (BMI) (2010)	2.5	3.4	5.4	-0.2	2.3	2.2
Coronary Artery Disease (CAD)	0.6	0.7	1.1	0.2	-1.0	-1.1
Crohns Disease (2012)	1.1	1.8	2.3	-1.5	1.5	0.9
Mean Putamen Volume	1.5	1.8	2.4	0.8	-1.5	-1.5
Fasting Glucose	0.0	0.0	0.1	0.4	-0.1	0.0
HbA1C	0.0	0.0	0.1	0.0	-0.1	0.3
HDL Cholesterol	0.3	0.4	1.1	-1.1	-0.3	0.3
LDL Cholesterol	0.4	0.7	0.9	1.0	-0.9	-0.4
Lupus	0.6	0.9	1.2	1.1	-1.0	-0.8
Neuroticism (2016)	0.3	0.5	1.1	1.1	-0.2	-0.5
Primary Biliary Cirrhosis	0.7	1.1	2.8	1.7	-0.6	-0.0
Rheumatoid Arthritis	0.1	0.2	0.4	-0.0	0.6	0.4
Schizophrenia (2014)	1.8	3.9	9.7	1.1	-3.1	-0.8
Triglycerides	2.7	4.5	5.3	2.0	-2.0	-2.3
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.4	0.5	0.7	0.4
Ulcerative Colitis	0.1	0.1	0.2	-0.5	-0.1	-0.4
Blood Eosinophil Count	0.8	6.3	10.4	2.4	-1.7	-3.2
Blood Platelet Count	0.2	2.2	4.4	0.7	-2.1	-1.4
Blood Red Count	1.3	12.7	28.3	2.5	-1.9	-5.3
Blood White Count	0.0	0.1	0.2	0.0	0.3	-0.4
Heel T-Score	0.1	0.6	1.1	0.9	0.3	-1.0
BMI	0.4	2.3	6.3	0.6	2.5	0.6
Height	0.7	12.6	19.9	-3.3	4.5	2.7
Waist Hip Ratio (WHR)	0.4	1.9	3.8	-1.3	-1.9	-0.6
Systolic Blood Pressure	0.0	0.2	0.3	-0.5	0.4	0.6
Smoking Status	2.0	4.8	9.5	0.7	-2.1	-3.1
Allergy or Eczema	0.4	1.0	1.6	1.2	0.2	-1.3
Cardiovascular Disease	0.3	1.1	2.4	0.4	0.9	1.6
Hypothyroidism (self reported)	0.4	1.0	2.2	1.5	0.2	-0.9
Respiratory disease	0.4	0.9	0.9	0.9	1.0	-0.9
Type 2 Diabetes (T2D) (2018)	5.5	10.3	13.1	-2.3	3.6	3.6
Lung FEV1/FVC ratio	0.5	2.3	6.6	-2.6	0.6	0.2
Lung FVC	0.2	1.2	2.6	1.6	-0.9	-0.1
Neuroticism	1.2	2.9	8.6	2.9	0.3	-0.1
Chronotype (morning person)	0.1	0.2	0.4	-0.7	-0.3	0.1
Hair Pigment	0.1	1.5	3.5	-0.2	-1.9	-0.9
Tanning	0.1	0.7	1.1	-0.9	1.1	0.5
Hand grip strength (left)	0.6	1.5	4.0	2.0	0.0	-0.7
Number of treatments/medications taken	0.1	0.1	0.2	0.4	0.1	-0.3
Average weekly spirits intake	0.3	0.4	0.8	-0.6	0.2	0.9
Sensitivity / hurt feelings	0.4	0.7	1.2	0.7	0.6	1.1
Frequency of depressed mood in last 2 weeks	2.6	3.6	7.8	2.8	-1.0	-1.4
Hearing difficulty/problems: Yes	0.5	0.8	1.3	-1.1	-0.6	-0.8
Relative age of first facial hair	2.6	5.3	6.8	1.7	-2.5	-2.6
Other serious medical condition/disability diagnosed by doctor	2.3	3.0	4.5	-0.4	2.1	2.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	-0.6	-0.1	1.0
Ever had hysterectomy (womb removed)	1.0	1.1	2.2	-0.3	1.0	1.5
Systolic blood pressure, automated reading	0.5	1.6	2.6	-1.6	1.2	0.8
Eye problems/disorders: Diabetes related eye disease	3.6	3.9	6.8	-0.8	2.1	2.6
Angina	0.2	0.3	0.5	0.0	-0.6	-0.7
Medication for hormone replacement therapy	0.2	0.3	0.6	-0.8	-0.2	0.3
Vitamin and mineral supplements	0.1	0.1	0.4	-0.1	0.6	0.2
Supplements: Zinc	0.1	0.1	0.3	0.6	-0.2	0.2
Medication: Co-codamol	1.4	1.6	3.2	1.8	-0.9	-0.9
Medication: Metformin	3.0	4.3	6.9	-1.4	2.6	2.0
Diabetes (father)	1.0	1.3	1.6	-1.3	1.0	1.1
Diabetes (mother)	0.8	1.0	2.9	1.7	0.2	-0.1
Severe depression (siblings)	0.3	0.4	0.6	0.6	-0.3	0.8
Pack years adult smoking proportion	0.3	0.5	0.8	0.5	-0.7	-0.9
Impedance of leg (right)	1.2	5.7	9.9	0.5	-3.1	-2.6
Leg fat-free mass (left)	1.5	7.9	18.0	-0.6	4.2	2.3
Trunk fat percentage	0.2	0.8	2.2	0.0	0.3	-1.5
Hand grip strength (right)	0.0	0.1	0.1	0.2	0.3	-0.2
Townsend deprivation index at recruitment	0.4	0.5	1.4	-1.2	0.4	0.2
Current tobacco smoking	1.8	3.0	4.5	0.3	-2.1	-2.1
Average weekly fortified wine intake	2.0	2.3	3.7	-1.9	1.6	0.9
Maternal smoking around birth	1.0	1.5	2.5	1.2	-1.6	-0.7
Fed-up feelings	1.0	1.7	4.9	2.2	0.3	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.3	1.2	0.2	-0.5
Relative age voice broke	0.7	1.1	2.5	-0.3	-1.6	-0.9
Taking other prescription medications	0.5	0.8	1.3	-0.0	1.0	1.1
Age when periods started (menarche)	1.5	3.5	4.4	1.7	-1.8	-2.1
Bilateral oophorectomy (both ovaries removed)	2.7	3.1	3.5	-1.7	1.9	1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.4	0.5	0.6	0.6
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	3.0	1.7	-0.7	-1.6
Qualifications: CSEs or equivalent	1.3	1.7	3.0	1.7	-0.8	-1.2
Serious illness, injury or assault to yourself	0.9	1.1	2.9	-0.4	0.5	1.7
High blood pressure	0.7	2.0	2.8	-1.7	1.5	1.1
Hayfever, allergic rhinitis or eczema	1.0	2.2	3.6	1.7	-0.2	-1.9
Multivitamins +/- minerals	0.6	0.7	1.4	-1.2	0.6	0.6
Stomach or abdominal pain in last month	3.0	3.8	4.6	1.8	-2.2	-1.9
Supplements: Glucosamine	0.1	0.2	0.2	0.4	0.4	-0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.0	-0.3	-0.5
Medication: Atenolol	1.3	1.7	2.7	0.3	1.5	1.6
Medication: Levothyroxine sodium	1.0	1.7	4.0	-0.1	2.0	1.1
Sitting height	2.0	14.3	24.3	-1.2	4.9	4.1
Chronic bronchitis/emphysema (father)	0.3	0.4	0.5	0.5	-0.7	-0.6
High blood pressure (mother)	0.7	0.9	1.0	1.0	0.9	1.0
Body mass index (BMI)	0.3	1.1	3.2	0.0	1.8	0.4
Impedance of leg (left)	1.5	7.5	13.1	0.7	-3.6	-3.0
Leg predicted mass (left)	1.5	7.8	17.7	-0.6	4.2	2.3
Trunk fat mass	0.2	0.9	2.2	-0.3	1.5	-0.6
Waist circumference	0.1	0.5	0.8	-0.9	0.9	-0.1
Number of incorrect matches in round	0.7	1.1	2.0	-0.8	0.8	1.4
Past tobacco smoking	0.2	0.4	0.6	0.4	0.7	0.8
Alcohol usually taken with meals	1.0	1.6	1.7	-1.3	1.3	1.2
Nervous feelings	1.1	2.1	4.9	2.2	-1.0	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.8	1.7	1.0	0.7
Hearing difficulty/problems with background noise	1.1	1.8	4.9	-2.2	-0.2	-0.7
Hair/balding pattern: Pattern 2	2.5	3.1	5.2	-1.0	1.8	2.3
Had menopause	0.2	0.2	0.5	-0.4	-0.0	0.7
Had other major operations	0.3	0.4	1.1	-1.0	-0.1	-0.3
Forced vital capacity (FVC)	0.3	1.2	1.6	0.8	1.3	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.4	-0.2	1.2	0.8
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.5	-0.1	-0.1	-0.7
Qualifications: None of the above	0.6	1.3	2.2	0.3	-1.5	-1.3
Financial difficulties in last 2 years	0.7	0.9	2.0	-0.6	1.4	0.5
Mouth/teeth dental problems	0.2	0.4	0.6	-0.8	0.6	0.5
Heart attack	0.1	0.1	0.4	0.2	-0.6	-0.1
Allergy	1.5	3.5	6.0	-2.4	0.0	2.1
Pain all over the body in last month	1.4	1.5	2.6	0.3	1.6	1.3
Diabetes (self-reported)	6.2	9.5	14.7	-1.2	3.8	3.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.7	0.8	0.1	-0.8
Medication: Ramipril	1.1	1.4	2.6	-0.3	1.6	1.2
Medication: Simvastatin	0.2	0.4	1.0	-0.3	0.1	1.0
Fluid intelligence score	0.7	1.5	2.3	-1.1	1.5	1.0
Illnesses of siblings	2.3	3.3	6.8	2.6	-0.7	-1.6
Neuroticism score	1.0	2.2	6.3	2.5	0.3	0.2
Weight	0.9	4.3	10.8	-0.7	3.3	1.3
Impedance of arm (right)	1.3	6.0	10.0	0.5	-3.2	-2.8
Arm fat percentage (right)	0.1	0.4	1.1	0.1	0.3	-1.1
Trunk fat-free mass	2.1	12.2	23.3	-1.4	4.8	3.4
Hip circumference	0.5	2.0	5.8	-0.2	2.4	0.4
Time employed in main current job	0.6	0.7	0.7	-0.8	0.8	0.8
Alcohol intake versus 10 years previously	0.5	0.8	1.4	-0.2	-1.0	-1.2
Father’s age at death	0.4	0.6	1.1	-1.1	-0.5	-0.6
Worrier / anxious feelings	1.6	3.0	8.6	2.9	-0.6	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	0.7	0.8	0.9	0.7
Falls in the last year	0.0	0.0	0.1	0.3	-0.0	-0.1
Hair/balding pattern: Pattern 3	0.4	0.6	1.4	-1.2	-0.1	0.7
Number of live births	6.2	8.7	9.2	3.0	-2.9	-3.0
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	4.8	-0.2	2.2	2.0
Pulse rate	0.4	0.6	1.2	-1.1	-0.5	-0.7
Happiness	0.6	0.7	1.5	1.2	-0.6	-0.6
Noisy workplace	0.5	0.6	1.7	1.3	-0.3	-0.4
Qualifications: A levels/AS levels or equivalent	4.0	8.8	11.6	-1.9	3.4	3.3
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.9	0.9	-0.6	-0.5
Mouth/teeth dental problems: Dentures	0.3	0.5	0.8	-0.7	-0.4	-0.9
Asthma	0.6	1.2	2.4	1.6	0.0	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	0.9	1.0	-0.7	-0.6
Medication: Cholesterol lowering	1.8	2.8	4.0	-1.9	1.0	2.0
Depression (self-reported)	0.1	0.1	0.2	0.4	0.2	0.4
Medication: Lansoprazole	0.5	0.6	1.6	-0.4	-0.3	-1.3
Prospective memory result	0.2	0.3	0.4	0.5	0.4	0.6
Lung cancer (father)	0.1	0.1	0.3	-0.1	-0.2	-0.6
Illnesses of mother	0.1	0.1	0.3	-0.5	-0.2	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.2	6.1	-1.0	2.5	2.3
Pulse wave Arterial Stiffness index	0.9	1.0	1.9	-1.4	0.9	0.6
Impedance of arm (left)	1.3	6.1	9.3	0.9	-3.0	-2.9
Arm fat mass (right)	0.2	0.8	2.5	-0.2	1.6	-0.1
Trunk predicted mass	2.1	11.9	22.7	-1.3	4.8	3.4
Standing height	0.6	6.3	12.8	-1.3	3.6	2.1
Length of working week for main job	0.8	0.9	1.6	0.4	-1.3	-0.9
Exposure to tobacco smoke at home	0.3	0.4	0.6	0.6	-0.8	-0.4
Breastfed as a baby	0.9	1.1	3.1	-1.7	0.1	-0.6
Tense / ‘highly strung’	0.8	1.3	3.8	2.0	-0.1	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	1.8	1.3	1.3	1.3
Hair/balding pattern: Pattern 4	1.4	3.4	4.4	-1.5	1.9	2.1
Birth weight of first child	0.5	1.0	1.7	0.9	-0.6	-1.3
Peak expiratory flow (PEF)	4.3	10.0	20.1	-0.9	4.5	3.0
Pulse wave reflection index	0.4	0.5	1.0	-1.0	0.5	0.5
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.0	0.4	-1.0	-0.1
Loud music exposure frequency	1.2	1.3	3.0	1.7	-0.8	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.6	0.3	0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.8	0.9	0.1	0.1
Blood clot in the leg (DVT)	0.9	1.1	2.4	0.4	1.6	0.9
Medication: Paracetamol	0.2	0.3	0.8	-0.9	0.3	-0.2
Headache pain in last month	0.7	1.3	3.2	1.8	0.1	0.8
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	5.1	1.0	-1.8	-2.3
Glaucoma (self-reported)	0.1	0.1	0.1	-0.3	0.2	0.3
Gout (self-reported)	2.4	3.4	4.8	2.2	-1.4	-1.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.5	1.2	0.7	0.2
Medication: Amlodipine	0.1	0.2	0.3	-0.4	-0.3	0.5
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.2	1.1	-0.5	-1.8
Birth weight	2.8	6.1	11.0	1.9	-1.9	-3.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	0.3	-0.5	-0.5
High blood pressure (siblings)	0.4	0.6	1.5	-1.2	-0.4	0.3
Forced vital capacity (FVC), Best measure	0.4	1.5	2.3	-0.3	1.5	1.5
Body fat percentage	0.2	0.8	2.3	0.1	0.2	-1.5
Leg fat percentage (right)	0.2	0.7	2.1	0.0	0.1	-1.4
Arm fat-free mass (right)	1.6	8.2	17.8	-0.6	4.2	2.5
Exposure to tobacco smoke outside home	0.1	0.2	0.3	0.3	-0.4	0.5
Comparative body size at age 10	0.4	1.2	1.9	1.2	1.4	0.3
Number of full brothers	0.4	0.4	0.9	-0.3	-0.6	-0.9
Worry too long after embarrassment	0.4	0.7	1.5	1.2	-0.8	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.6	-0.4	0.8	1.6
Wheeze or whistling in the chest in last year	0.4	0.8	1.6	1.2	0.7	-0.6
Number of children fathered	0.4	0.5	0.7	0.9	0.6	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.5	1.6	0.3	0.4
Age at first live birth	0.4	0.6	1.0	-1.0	-0.2	-0.9
Pulse wave peak to peak time	0.8	0.9	1.7	1.3	-0.9	-0.6
Health satisfaction	0.3	0.4	0.9	-0.0	0.9	0.7
Shortness of breath walking on level ground	0.5	0.6	1.4	-1.2	0.6	0.3
Qualifications: College or University degree	0.3	1.1	1.7	-1.0	1.3	0.7
Eye problems/disorders: None of the above	3.2	3.7	5.5	-1.6	2.3	1.8
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.4	0.0	0.6	0.7
Emphysema/chronic bronchitis	8.8	9.9	13.9	2.8	-2.9	-3.7
Medication for pain relief, constipation, heartburn	0.0	0.0	0.1	0.1	-0.3	0.0
Neck or shoulder pain in last month	0.3	0.5	0.8	0.6	-0.9	-0.4
Medication: Blood pressure	1.0	1.8	3.5	-0.5	1.9	1.4
Angina (self-reported)	0.2	0.3	0.5	0.1	-0.7	-0.7
Migraine (self-reported)	0.8	1.0	2.2	1.5	-0.5	-0.7
Medication: Ibuprofen	0.3	0.4	0.8	0.9	-0.5	-0.4
Medication: Allopurinol	4.3	5.7	6.7	2.6	-2.0	-2.5
Medication: Omeprazole	0.2	0.3	0.6	-0.2	-0.4	-0.8
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.4	-0.5	0.4
Mean time to correctly identify matches	0.8	1.5	2.8	-1.7	-1.3	0.1
Heart disease (mother)	0.4	0.5	0.7	0.8	-0.8	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	2.8	1.4	-0.7	-1.7
Whole body fat mass	0.2	0.8	2.0	-0.3	1.4	-0.5
Leg fat mass (right)	0.2	0.6	1.8	-0.1	1.3	-0.3
Arm predicted mass (right)	1.6	8.1	17.1	-0.6	4.1	2.6
Pulse rate, automated reading	0.2	0.6	1.2	-1.1	-0.6	-0.4
Alcohol intake frequency.	1.7	4.0	5.8	2.4	-1.8	-1.7
Comparative height size at age 10	1.7	9.3	16.4	-2.1	4.0	2.6
Number of full sisters	1.9	2.3	3.3	1.6	-1.8	-1.0
Suffer from ‘nerves’	0.6	0.9	2.4	1.5	0.3	-0.5
Overall health rating	0.0	0.0	0.0	0.0	-0.1	0.0
Chest pain or discomfort	0.3	0.5	0.9	-0.0	0.8	0.9
Had major operations	0.4	0.5	0.9	-0.0	1.0	-0.7
Age at last live birth	0.7	1.1	2.4	-0.2	-0.9	-1.5
Family relationship satisfaction	0.2	0.2	0.2	0.4	-0.4	0.5
Leg pain on walking	0.2	0.3	0.5	0.7	0.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	4.2	2.0	-0.2	-0.8
Commuting to job workplace: Car/motor vehicle	1.4	1.6	4.2	2.1	0.5	0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	0.2	-0.8	-0.3
Medication: Aspirin	0.7	0.9	1.5	-0.9	0.8	1.2
Supplements: Vitamin C	2.5	2.9	4.3	2.1	-1.7	-1.3
Knee pain experienced in last month	0.4	0.7	1.7	-0.4	-0.4	-1.3
Hypertension (Self-reported)	1.2	3.3	4.0	-1.9	2.0	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	3.1	0.8	-1.5	-1.8
Illnesses of father: Heart disease	0.6	0.8	2.0	-0.6	-0.1	1.4
Illnesses of siblings: Diabetes	3.4	4.2	6.0	-1.9	1.7	2.4
Smoking status: Previous	0.2	0.3	0.5	-0.2	0.7	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	3.0	-0.9	1.7	1.3
Whole body fat-free mass	1.9	11.0	22.7	-1.0	4.8	3.1
Leg fat-free mass (right)	1.4	7.5	16.6	-0.4	4.1	2.4
Arm fat percentage (left)	0.1	0.4	1.0	0.1	0.4	-1.0
Average weekly red wine intake	2.2	3.3	4.0	-2.0	1.7	1.7
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.3	1.1	-0.1	1.1
Mood swings	0.9	1.6	4.0	2.0	0.1	0.8
Loneliness, isolation	0.9	1.2	3.1	1.8	0.5	-0.6
Long-standing illness, disability or infirmity	0.4	0.5	1.0	-0.1	1.0	0.8
Ever had bowel cancer screening	0.9	1.0	2.6	-0.1	-0.7	-1.6
Diabetes diagnosed by doctor	6.6	10.8	15.8	-1.7	4.0	3.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	-0.1	0.2	0.7
Friendships satisfaction	0.2	0.3	0.6	0.2	-0.8	-0.5
Qualifications: nursing, teaching	0.3	0.5	0.5	-0.7	0.7	0.7
Commuting to job workplace: Walk	2.1	2.2	5.1	-2.3	1.0	0.8
Eye problems/disorders: Cataract	4.5	5.2	7.4	1.4	-2.7	-2.5
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	1.9	1.4	-1.1	-0.8
Medication for cholesterol	0.2	0.3	0.8	0.9	0.0	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	0.1	0.6	0.6
Back pain experienced in last month	0.2	0.3	0.9	1.0	0.1	-0.2
Mineral and other dietary supplements	0.8	1.1	3.1	-1.8	0.1	0.5
Breast cancer (self-reported)	0.7	0.9	1.7	0.8	0.6	1.3
Asthma (self-reported)	0.6	1.2	1.9	1.4	0.2	-1.2
Osteoporosis (self-reported)	1.3	1.6	2.6	1.6	-0.8	-1.2
Osteoarthritis (self-reported)	0.2	0.3	0.4	0.7	0.6	-0.2
Medication: Aspirin	0.5	0.6	1.0	-0.7	0.6	1.0
Medication: Gliclazide	0.6	0.6	1.3	-0.3	1.2	0.7
Illnesses of father: None of the above (group 1)	0.3	0.4	0.9	1.0	-0.2	-0.5
Smoking status: Current	2.0	3.3	5.0	0.4	-2.2	-2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	3.2	-1.2	1.8	1.8
Whole body water mass	1.8	10.2	21.2	-0.9	4.6	2.9
Leg predicted mass (right)	1.5	8.0	17.6	-0.4	4.2	2.5
Arm fat mass (left)	0.2	0.9	2.7	-0.2	1.6	0.0
Number of self-reported non-cancer illnesses	0.9	1.5	4.0	0.3	2.0	0.7
Average weekly champagne plus white wine intake	1.4	1.9	3.6	-1.9	0.9	1.1
Miserableness	0.6	1.1	1.6	1.2	1.2	-0.3
Guilty feelings	0.6	0.9	1.6	1.3	0.2	1.0
Wears glasses or contact lenses	0.3	0.3	0.7	-0.5	0.9	0.2
Ever taken oral contraceptive pill	1.7	1.9	3.8	-0.7	2.0	1.2
Hearing aid user	0.4	0.5	1.1	-1.1	0.6	0.3
Mother’s age at death	1.7	2.2	6.4	-2.5	-0.1	0.3
Financial situation satisfaction	0.1	0.1	0.2	0.4	0.3	0.2
Tinnitus: Yes, now most or all of the time	1.7	2.0	5.6	2.4	0.4	0.5
Commuting to job workplace: Public transport	1.1	1.3	2.5	-1.6	1.0	0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	0.4	0.3	0.6
Medication: Blood pressure	0.3	0.6	1.2	-1.1	0.7	0.1
Pain type(s) experienced in last month: Hip pain	2.2	2.7	6.3	2.5	-0.0	-1.4
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.5	1.6	0.7	0.9
High cholesterol (Self-reported)	0.1	0.3	0.5	-0.2	-0.7	0.5
Medication: Bendroflumethiazide	0.6	0.9	1.6	-0.2	1.0	1.3
Medication: Paracetamol	0.5	0.7	1.7	-1.3	-0.4	-0.6
Medication: Lisinopril	1.2	1.6	2.1	-1.4	0.9	1.5
Medication: Atorvastatin	1.2	1.5	3.1	-1.8	0.6	1.0
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.4	-0.0	-0.2
Alcohol drinker status: Never	0.0	0.0	0.1	0.3	-0.1	-0.1
Ever smoked	0.3	0.5	0.6	-0.8	-0.6	-0.8
Basal metabolic rate	1.6	8.6	18.9	-0.8	4.3	2.5
Leg fat percentage (left)	0.2	0.8	2.4	-0.0	0.0	-1.5
Arm fat-free mass (left)	2.0	10.2	20.2	-1.1	4.5	3.1
Number of operations (self-reported)	1.5	2.3	3.6	-1.9	1.7	0.6
Average weekly beer plus cider intake	0.1	0.2	0.2	0.5	-0.4	-0.3
Irritability	1.5	2.5	6.2	2.5	-1.1	0.0
Risk taking	2.6	3.8	9.8	-3.1	0.3	1.2
Ever had prostate specific antigen (PSA) test	1.4	1.6	2.3	-1.1	1.5	1.2
Fractured/broken bones in last 5 years	1.3	1.7	3.6	1.9	0.1	1.2
Age started oral contraceptive pill	0.6	0.8	1.5	-0.1	-1.0	-1.2
Diastolic blood pressure, automated reading	0.1	0.4	0.7	0.2	-0.7	-0.9
Ever depressed for a whole week	0.3	0.4	0.7	-0.7	0.9	-0.3
Unable to work because of sickness or disability	0.0	0.0	0.1	-0.2	-0.0	-0.2
Commuting to job workplace: Cycle	2.0	2.4	3.8	-1.4	1.2	2.0
Myopia	3.0	4.4	6.6	2.0	-1.6	-2.6
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.0	1.4	-1.0	-0.6
Cholesterol lowering medication	0.2	0.3	0.8	-0.0	-0.9	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.6	-0.2	-0.2	-1.3
Pain experienced in last month	0.4	0.7	2.0	-1.4	-0.3	0.2
Supplements: Calcium	1.3	1.4	2.2	1.5	-1.0	-1.0
Basal cell carcinoma (self-reported)	0.9	1.1	1.9	1.4	-0.5	-1.0
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.4	0.2	-0.6	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.9	0.5	1.4	0.5
Heart disease (siblings)	2.0	2.4	3.3	-1.6	1.1	1.8
Alcohol drinker status: Previous	2.0	2.3	3.6	1.9	-1.2	-1.3
Pack years of smoking	0.3	0.4	0.6	0.4	-0.7	-0.8
Impedance of whole body	1.8	9.0	14.2	1.2	-3.8	-3.4
Leg fat mass (left)	0.2	0.7	2.1	-0.3	1.4	-0.2
Arm predicted mass (left)	1.7	8.6	17.1	-0.9	4.1	2.8