Hub : Genes

FAM13B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Muscularis 0.1890 0.0770 0.0012 0.024 NA 0.037 NA 0.015 1.3e-02 NA 2.5e-03 NA 4.1e-02
2 NTR Blood 0.0110 0.0054 0.0036 0.001 0.006 0.001 0.006 0.003 1.3e-01 3.1e-03 1.1e-01 5.1e-03 4.2e-02
3 YFS Blood 0.0565 0.0152 0.0000 0.083 0.086 0.091 0.089 0.094 1.1e-25 9.0e-27 2.9e-28 1.4e-27 5.3e-29

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.4 0.6 0.8 0.8 -0.9 0.4
Bipolar Disorder or Schizophrenia 1.5 3.6 7.5 1.8 -2.7 -0.5
Depressed Affect (Nagel 2018) 1.1 2.3 5.2 2.3 1.2 0.5
Depression (Nagel 2018) 2.3 3.5 8.5 2.9 -0.9 -1.0
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.2 -0.7 0.7 1.1
Neuroticism (Nagel 2018) 1.5 3.6 10.8 3.3 0.0 0.3
Schizophrenia (2018) 1.9 3.9 7.7 1.9 -2.8 -0.8
Schizophrenia vs Biploar Disorder 2.0 2.7 5.3 -0.9 -2.3 -1.4
Worry (Nagel 2018) 1.5 3.2 9.3 3.0 -0.2 -0.4
Alzheimer’s Disease (in mother) 1.3 1.6 3.7 -1.9 0.1 1.0
Alzheimer’s Disease (in father) 0.7 0.8 2.3 -1.5 0.3 -0.2
Alzheimer’s Disease (including proxy) 1.5 2.2 5.8 -2.4 -0.5 0.7
Crohns Disease (2017) 0.5 1.2 2.5 -0.6 1.6 0.8
Irritable Bowel Disease (IBD) 0.5 1.2 1.7 -1.3 1.2 0.8
Ulcerative Colitis (UC) 0.5 1.0 2.5 -1.6 0.5 0.4
Major Depression (MDD) 0.5 0.6 1.4 1.2 0.6 0.3
Reaction Time 0.5 0.9 1.9 -1.4 -0.7 0.4
Verbal and Numeric Reasoning (VNR) 0.3 0.6 1.3 -0.5 1.1 0.5
Breast Cancer 1.5 3.7 5.2 2.3 -1.5 -1.9
Ovarian Cancer 0.8 1.0 1.2 1.0 1.1 0.9
Prostate Cancer 1.2 1.7 2.7 -0.0 1.6 1.6
Age at First Birth 0.4 0.7 1.0 -0.9 0.4 1.0
Bipolar Disorder (2011) 0.3 0.3 0.9 0.3 -0.9 -0.0
Body Mass Index (BMI) (2010) 2.5 3.4 5.4 -0.2 2.3 2.2
Coronary Artery Disease (CAD) 0.6 0.7 1.1 0.2 -1.0 -1.1
Crohns Disease (2012) 1.1 1.8 2.3 -1.5 1.5 0.9
Mean Putamen Volume 1.5 1.8 2.4 0.8 -1.5 -1.5
Fasting Glucose 0.0 0.0 0.1 0.4 -0.1 0.0
HbA1C 0.0 0.0 0.1 0.0 -0.1 0.3
HDL Cholesterol 0.3 0.4 1.1 -1.1 -0.3 0.3
LDL Cholesterol 0.4 0.7 0.9 1.0 -0.9 -0.4
Lupus 0.6 0.9 1.2 1.1 -1.0 -0.8
Neuroticism (2016) 0.3 0.5 1.1 1.1 -0.2 -0.5
Primary Biliary Cirrhosis 0.7 1.1 2.8 1.7 -0.6 -0.0
Rheumatoid Arthritis 0.1 0.2 0.4 -0.0 0.6 0.4
Schizophrenia (2014) 1.8 3.9 9.7 1.1 -3.1 -0.8
Triglycerides 2.7 4.5 5.3 2.0 -2.0 -2.3
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.4 0.5 0.7 0.4
Ulcerative Colitis 0.1 0.1 0.2 -0.5 -0.1 -0.4
Blood Eosinophil Count 0.8 6.3 10.4 2.4 -1.7 -3.2
Blood Platelet Count 0.2 2.2 4.4 0.7 -2.1 -1.4
Blood Red Count 1.3 12.7 28.3 2.5 -1.9 -5.3
Blood White Count 0.0 0.1 0.2 0.0 0.3 -0.4
Heel T-Score 0.1 0.6 1.1 0.9 0.3 -1.0
BMI 0.4 2.3 6.3 0.6 2.5 0.6
Height 0.7 12.6 19.9 -3.3 4.5 2.7
Waist Hip Ratio (WHR) 0.4 1.9 3.8 -1.3 -1.9 -0.6
Systolic Blood Pressure 0.0 0.2 0.3 -0.5 0.4 0.6
Smoking Status 2.0 4.8 9.5 0.7 -2.1 -3.1
Allergy or Eczema 0.4 1.0 1.6 1.2 0.2 -1.3
Cardiovascular Disease 0.3 1.1 2.4 0.4 0.9 1.6
Hypothyroidism (self reported) 0.4 1.0 2.2 1.5 0.2 -0.9
Respiratory disease 0.4 0.9 0.9 0.9 1.0 -0.9
Type 2 Diabetes (T2D) (2018) 5.5 10.3 13.1 -2.3 3.6 3.6
Lung FEV1/FVC ratio 0.5 2.3 6.6 -2.6 0.6 0.2
Lung FVC 0.2 1.2 2.6 1.6 -0.9 -0.1
Neuroticism 1.2 2.9 8.6 2.9 0.3 -0.1
Chronotype (morning person) 0.1 0.2 0.4 -0.7 -0.3 0.1
Hair Pigment 0.1 1.5 3.5 -0.2 -1.9 -0.9
Tanning 0.1 0.7 1.1 -0.9 1.1 0.5
Hand grip strength (left) 0.6 1.5 4.0 2.0 0.0 -0.7
Number of treatments/medications taken 0.1 0.1 0.2 0.4 0.1 -0.3
Average weekly spirits intake 0.3 0.4 0.8 -0.6 0.2 0.9
Sensitivity / hurt feelings 0.4 0.7 1.2 0.7 0.6 1.1
Frequency of depressed mood in last 2 weeks 2.6 3.6 7.8 2.8 -1.0 -1.4
Hearing difficulty/problems: Yes 0.5 0.8 1.3 -1.1 -0.6 -0.8
Relative age of first facial hair 2.6 5.3 6.8 1.7 -2.5 -2.6
Other serious medical condition/disability diagnosed by doctor 2.3 3.0 4.5 -0.4 2.1 2.1
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.0 -0.6 -0.1 1.0
Ever had hysterectomy (womb removed) 1.0 1.1 2.2 -0.3 1.0 1.5
Systolic blood pressure, automated reading 0.5 1.6 2.6 -1.6 1.2 0.8
Eye problems/disorders: Diabetes related eye disease 3.6 3.9 6.8 -0.8 2.1 2.6
Angina 0.2 0.3 0.5 0.0 -0.6 -0.7
Medication for hormone replacement therapy 0.2 0.3 0.6 -0.8 -0.2 0.3
Vitamin and mineral supplements 0.1 0.1 0.4 -0.1 0.6 0.2
Supplements: Zinc 0.1 0.1 0.3 0.6 -0.2 0.2
Medication: Co-codamol 1.4 1.6 3.2 1.8 -0.9 -0.9
Medication: Metformin 3.0 4.3 6.9 -1.4 2.6 2.0
Diabetes (father) 1.0 1.3 1.6 -1.3 1.0 1.1
Diabetes (mother) 0.8 1.0 2.9 1.7 0.2 -0.1
Severe depression (siblings) 0.3 0.4 0.6 0.6 -0.3 0.8
Pack years adult smoking proportion 0.3 0.5 0.8 0.5 -0.7 -0.9
Impedance of leg (right) 1.2 5.7 9.9 0.5 -3.1 -2.6
Leg fat-free mass (left) 1.5 7.9 18.0 -0.6 4.2 2.3
Trunk fat percentage 0.2 0.8 2.2 0.0 0.3 -1.5
Hand grip strength (right) 0.0 0.1 0.1 0.2 0.3 -0.2
Townsend deprivation index at recruitment 0.4 0.5 1.4 -1.2 0.4 0.2
Current tobacco smoking 1.8 3.0 4.5 0.3 -2.1 -2.1
Average weekly fortified wine intake 2.0 2.3 3.7 -1.9 1.6 0.9
Maternal smoking around birth 1.0 1.5 2.5 1.2 -1.6 -0.7
Fed-up feelings 1.0 1.7 4.9 2.2 0.3 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.3 1.2 0.2 -0.5
Relative age voice broke 0.7 1.1 2.5 -0.3 -1.6 -0.9
Taking other prescription medications 0.5 0.8 1.3 -0.0 1.0 1.1
Age when periods started (menarche) 1.5 3.5 4.4 1.7 -1.8 -2.1
Bilateral oophorectomy (both ovaries removed) 2.7 3.1 3.5 -1.7 1.9 1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 0.4 0.5 0.6 0.6
Tinnitus: Yes, but not now, but have in the past 1.9 2.0 3.0 1.7 -0.7 -1.6
Qualifications: CSEs or equivalent 1.3 1.7 3.0 1.7 -0.8 -1.2
Serious illness, injury or assault to yourself 0.9 1.1 2.9 -0.4 0.5 1.7
High blood pressure 0.7 2.0 2.8 -1.7 1.5 1.1
Hayfever, allergic rhinitis or eczema 1.0 2.2 3.6 1.7 -0.2 -1.9
Multivitamins +/- minerals 0.6 0.7 1.4 -1.2 0.6 0.6
Stomach or abdominal pain in last month 3.0 3.8 4.6 1.8 -2.2 -1.9
Supplements: Glucosamine 0.1 0.2 0.2 0.4 0.4 -0.4
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.3 0.0 -0.3 -0.5
Medication: Atenolol 1.3 1.7 2.7 0.3 1.5 1.6
Medication: Levothyroxine sodium 1.0 1.7 4.0 -0.1 2.0 1.1
Sitting height 2.0 14.3 24.3 -1.2 4.9 4.1
Chronic bronchitis/emphysema (father) 0.3 0.4 0.5 0.5 -0.7 -0.6
High blood pressure (mother) 0.7 0.9 1.0 1.0 0.9 1.0
Body mass index (BMI) 0.3 1.1 3.2 0.0 1.8 0.4
Impedance of leg (left) 1.5 7.5 13.1 0.7 -3.6 -3.0
Leg predicted mass (left) 1.5 7.8 17.7 -0.6 4.2 2.3
Trunk fat mass 0.2 0.9 2.2 -0.3 1.5 -0.6
Waist circumference 0.1 0.5 0.8 -0.9 0.9 -0.1
Number of incorrect matches in round 0.7 1.1 2.0 -0.8 0.8 1.4
Past tobacco smoking 0.2 0.4 0.6 0.4 0.7 0.8
Alcohol usually taken with meals 1.0 1.6 1.7 -1.3 1.3 1.2
Nervous feelings 1.1 2.1 4.9 2.2 -1.0 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 2.8 1.7 1.0 0.7
Hearing difficulty/problems with background noise 1.1 1.8 4.9 -2.2 -0.2 -0.7
Hair/balding pattern: Pattern 2 2.5 3.1 5.2 -1.0 1.8 2.3
Had menopause 0.2 0.2 0.5 -0.4 -0.0 0.7
Had other major operations 0.3 0.4 1.1 -1.0 -0.1 -0.3
Forced vital capacity (FVC) 0.3 1.2 1.6 0.8 1.3 1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.4 -0.2 1.2 0.8
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.5 -0.1 -0.1 -0.7
Qualifications: None of the above 0.6 1.3 2.2 0.3 -1.5 -1.3
Financial difficulties in last 2 years 0.7 0.9 2.0 -0.6 1.4 0.5
Mouth/teeth dental problems 0.2 0.4 0.6 -0.8 0.6 0.5
Heart attack 0.1 0.1 0.4 0.2 -0.6 -0.1
Allergy 1.5 3.5 6.0 -2.4 0.0 2.1
Pain all over the body in last month 1.4 1.5 2.6 0.3 1.6 1.3
Diabetes (self-reported) 6.2 9.5 14.7 -1.2 3.8 3.5
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.7 0.8 0.1 -0.8
Medication: Ramipril 1.1 1.4 2.6 -0.3 1.6 1.2
Medication: Simvastatin 0.2 0.4 1.0 -0.3 0.1 1.0
Fluid intelligence score 0.7 1.5 2.3 -1.1 1.5 1.0
Illnesses of siblings 2.3 3.3 6.8 2.6 -0.7 -1.6
Neuroticism score 1.0 2.2 6.3 2.5 0.3 0.2
Weight 0.9 4.3 10.8 -0.7 3.3 1.3
Impedance of arm (right) 1.3 6.0 10.0 0.5 -3.2 -2.8
Arm fat percentage (right) 0.1 0.4 1.1 0.1 0.3 -1.1
Trunk fat-free mass 2.1 12.2 23.3 -1.4 4.8 3.4
Hip circumference 0.5 2.0 5.8 -0.2 2.4 0.4
Time employed in main current job 0.6 0.7 0.7 -0.8 0.8 0.8
Alcohol intake versus 10 years previously 0.5 0.8 1.4 -0.2 -1.0 -1.2
Father’s age at death 0.4 0.6 1.1 -1.1 -0.5 -0.6
Worrier / anxious feelings 1.6 3.0 8.6 2.9 -0.6 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 0.7 0.8 0.9 0.7
Falls in the last year 0.0 0.0 0.1 0.3 -0.0 -0.1
Hair/balding pattern: Pattern 3 0.4 0.6 1.4 -1.2 -0.1 0.7
Number of live births 6.2 8.7 9.2 3.0 -2.9 -3.0
Forced expiratory volume in 1-second (FEV1) 0.9 2.9 4.8 -0.2 2.2 2.0
Pulse rate 0.4 0.6 1.2 -1.1 -0.5 -0.7
Happiness 0.6 0.7 1.5 1.2 -0.6 -0.6
Noisy workplace 0.5 0.6 1.7 1.3 -0.3 -0.4
Qualifications: A levels/AS levels or equivalent 4.0 8.8 11.6 -1.9 3.4 3.3
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 0.9 0.9 -0.6 -0.5
Mouth/teeth dental problems: Dentures 0.3 0.5 0.8 -0.7 -0.4 -0.9
Asthma 0.6 1.2 2.4 1.6 0.0 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 0.9 1.0 -0.7 -0.6
Medication: Cholesterol lowering 1.8 2.8 4.0 -1.9 1.0 2.0
Depression (self-reported) 0.1 0.1 0.2 0.4 0.2 0.4
Medication: Lansoprazole 0.5 0.6 1.6 -0.4 -0.3 -1.3
Prospective memory result 0.2 0.3 0.4 0.5 0.4 0.6
Lung cancer (father) 0.1 0.1 0.3 -0.1 -0.2 -0.6
Illnesses of mother 0.1 0.1 0.3 -0.5 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.2 6.1 -1.0 2.5 2.3
Pulse wave Arterial Stiffness index 0.9 1.0 1.9 -1.4 0.9 0.6
Impedance of arm (left) 1.3 6.1 9.3 0.9 -3.0 -2.9
Arm fat mass (right) 0.2 0.8 2.5 -0.2 1.6 -0.1
Trunk predicted mass 2.1 11.9 22.7 -1.3 4.8 3.4
Standing height 0.6 6.3 12.8 -1.3 3.6 2.1
Length of working week for main job 0.8 0.9 1.6 0.4 -1.3 -0.9
Exposure to tobacco smoke at home 0.3 0.4 0.6 0.6 -0.8 -0.4
Breastfed as a baby 0.9 1.1 3.1 -1.7 0.1 -0.6
Tense / ‘highly strung’ 0.8 1.3 3.8 2.0 -0.1 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 1.8 1.3 1.3 1.3
Hair/balding pattern: Pattern 4 1.4 3.4 4.4 -1.5 1.9 2.1
Birth weight of first child 0.5 1.0 1.7 0.9 -0.6 -1.3
Peak expiratory flow (PEF) 4.3 10.0 20.1 -0.9 4.5 3.0
Pulse wave reflection index 0.4 0.5 1.0 -1.0 0.5 0.5
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.0 0.4 -1.0 -0.1
Loud music exposure frequency 1.2 1.3 3.0 1.7 -0.8 0.3
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.3 0.6 0.3 0.3
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.8 0.9 0.1 0.1
Blood clot in the leg (DVT) 0.9 1.1 2.4 0.4 1.6 0.9
Medication: Paracetamol 0.2 0.3 0.8 -0.9 0.3 -0.2
Headache pain in last month 0.7 1.3 3.2 1.8 0.1 0.8
Medication for cholesterol, blood pressure or diabetes 1.9 3.1 5.1 1.0 -1.8 -2.3
Glaucoma (self-reported) 0.1 0.1 0.1 -0.3 0.2 0.3
Gout (self-reported) 2.4 3.4 4.8 2.2 -1.4 -1.8
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 1.5 1.2 0.7 0.2
Medication: Amlodipine 0.1 0.2 0.3 -0.4 -0.3 0.5
Medication: Ventolin 100micrograms inhaler 1.2 1.5 3.2 1.1 -0.5 -1.8
Birth weight 2.8 6.1 11.0 1.9 -1.9 -3.3
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.3 0.3 -0.5 -0.5
High blood pressure (siblings) 0.4 0.6 1.5 -1.2 -0.4 0.3
Forced vital capacity (FVC), Best measure 0.4 1.5 2.3 -0.3 1.5 1.5
Body fat percentage 0.2 0.8 2.3 0.1 0.2 -1.5
Leg fat percentage (right) 0.2 0.7 2.1 0.0 0.1 -1.4
Arm fat-free mass (right) 1.6 8.2 17.8 -0.6 4.2 2.5
Exposure to tobacco smoke outside home 0.1 0.2 0.3 0.3 -0.4 0.5
Comparative body size at age 10 0.4 1.2 1.9 1.2 1.4 0.3
Number of full brothers 0.4 0.4 0.9 -0.3 -0.6 -0.9
Worry too long after embarrassment 0.4 0.7 1.5 1.2 -0.8 -0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.1 2.6 -0.4 0.8 1.6
Wheeze or whistling in the chest in last year 0.4 0.8 1.6 1.2 0.7 -0.6
Number of children fathered 0.4 0.5 0.7 0.9 0.6 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 2.5 1.6 0.3 0.4
Age at first live birth 0.4 0.6 1.0 -1.0 -0.2 -0.9
Pulse wave peak to peak time 0.8 0.9 1.7 1.3 -0.9 -0.6
Health satisfaction 0.3 0.4 0.9 -0.0 0.9 0.7
Shortness of breath walking on level ground 0.5 0.6 1.4 -1.2 0.6 0.3
Qualifications: College or University degree 0.3 1.1 1.7 -1.0 1.3 0.7
Eye problems/disorders: None of the above 3.2 3.7 5.5 -1.6 2.3 1.8
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.4 0.0 0.6 0.7
Emphysema/chronic bronchitis 8.8 9.9 13.9 2.8 -2.9 -3.7
Medication for pain relief, constipation, heartburn 0.0 0.0 0.1 0.1 -0.3 0.0
Neck or shoulder pain in last month 0.3 0.5 0.8 0.6 -0.9 -0.4
Medication: Blood pressure 1.0 1.8 3.5 -0.5 1.9 1.4
Angina (self-reported) 0.2 0.3 0.5 0.1 -0.7 -0.7
Migraine (self-reported) 0.8 1.0 2.2 1.5 -0.5 -0.7
Medication: Ibuprofen 0.3 0.4 0.8 0.9 -0.5 -0.4
Medication: Allopurinol 4.3 5.7 6.7 2.6 -2.0 -2.5
Medication: Omeprazole 0.2 0.3 0.6 -0.2 -0.4 -0.8
Medication: Seretide 50 evohaler 0.2 0.2 0.3 -0.4 -0.5 0.4
Mean time to correctly identify matches 0.8 1.5 2.8 -1.7 -1.3 0.1
Heart disease (mother) 0.4 0.5 0.7 0.8 -0.8 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.5 1.8 2.8 1.4 -0.7 -1.7
Whole body fat mass 0.2 0.8 2.0 -0.3 1.4 -0.5
Leg fat mass (right) 0.2 0.6 1.8 -0.1 1.3 -0.3
Arm predicted mass (right) 1.6 8.1 17.1 -0.6 4.1 2.6
Pulse rate, automated reading 0.2 0.6 1.2 -1.1 -0.6 -0.4
Alcohol intake frequency. 1.7 4.0 5.8 2.4 -1.8 -1.7
Comparative height size at age 10 1.7 9.3 16.4 -2.1 4.0 2.6
Number of full sisters 1.9 2.3 3.3 1.6 -1.8 -1.0
Suffer from ‘nerves’ 0.6 0.9 2.4 1.5 0.3 -0.5
Overall health rating 0.0 0.0 0.0 0.0 -0.1 0.0
Chest pain or discomfort 0.3 0.5 0.9 -0.0 0.8 0.9
Had major operations 0.4 0.5 0.9 -0.0 1.0 -0.7
Age at last live birth 0.7 1.1 2.4 -0.2 -0.9 -1.5
Family relationship satisfaction 0.2 0.2 0.2 0.4 -0.4 0.5
Leg pain on walking 0.2 0.3 0.5 0.7 0.5 0.1
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 4.2 2.0 -0.2 -0.8
Commuting to job workplace: Car/motor vehicle 1.4 1.6 4.2 2.1 0.5 0.3
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.7 0.2 -0.8 -0.3
Medication: Aspirin 0.7 0.9 1.5 -0.9 0.8 1.2
Supplements: Vitamin C 2.5 2.9 4.3 2.1 -1.7 -1.3
Knee pain experienced in last month 0.4 0.7 1.7 -0.4 -0.4 -1.3
Hypertension (Self-reported) 1.2 3.3 4.0 -1.9 2.0 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 2.0 3.1 0.8 -1.5 -1.8
Illnesses of father: Heart disease 0.6 0.8 2.0 -0.6 -0.1 1.4
Illnesses of siblings: Diabetes 3.4 4.2 6.0 -1.9 1.7 2.4
Smoking status: Previous 0.2 0.3 0.5 -0.2 0.7 0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 3.0 -0.9 1.7 1.3
Whole body fat-free mass 1.9 11.0 22.7 -1.0 4.8 3.1
Leg fat-free mass (right) 1.4 7.5 16.6 -0.4 4.1 2.4
Arm fat percentage (left) 0.1 0.4 1.0 0.1 0.4 -1.0
Average weekly red wine intake 2.2 3.3 4.0 -2.0 1.7 1.7
Handedness (chirality/laterality): Left-handed 0.7 0.9 1.3 1.1 -0.1 1.1
Mood swings 0.9 1.6 4.0 2.0 0.1 0.8
Loneliness, isolation 0.9 1.2 3.1 1.8 0.5 -0.6
Long-standing illness, disability or infirmity 0.4 0.5 1.0 -0.1 1.0 0.8
Ever had bowel cancer screening 0.9 1.0 2.6 -0.1 -0.7 -1.6
Diabetes diagnosed by doctor 6.6 10.8 15.8 -1.7 4.0 3.7
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.5 -0.1 0.2 0.7
Friendships satisfaction 0.2 0.3 0.6 0.2 -0.8 -0.5
Qualifications: nursing, teaching 0.3 0.5 0.5 -0.7 0.7 0.7
Commuting to job workplace: Walk 2.1 2.2 5.1 -2.3 1.0 0.8
Eye problems/disorders: Cataract 4.5 5.2 7.4 1.4 -2.7 -2.5
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 1.9 1.4 -1.1 -0.8
Medication for cholesterol 0.2 0.3 0.8 0.9 0.0 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.4 0.1 0.6 0.6
Back pain experienced in last month 0.2 0.3 0.9 1.0 0.1 -0.2
Mineral and other dietary supplements 0.8 1.1 3.1 -1.8 0.1 0.5
Breast cancer (self-reported) 0.7 0.9 1.7 0.8 0.6 1.3
Asthma (self-reported) 0.6 1.2 1.9 1.4 0.2 -1.2
Osteoporosis (self-reported) 1.3 1.6 2.6 1.6 -0.8 -1.2
Osteoarthritis (self-reported) 0.2 0.3 0.4 0.7 0.6 -0.2
Medication: Aspirin 0.5 0.6 1.0 -0.7 0.6 1.0
Medication: Gliclazide 0.6 0.6 1.3 -0.3 1.2 0.7
Illnesses of father: None of the above (group 1) 0.3 0.4 0.9 1.0 -0.2 -0.5
Smoking status: Current 2.0 3.3 5.0 0.4 -2.2 -2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.6 3.2 -1.2 1.8 1.8
Whole body water mass 1.8 10.2 21.2 -0.9 4.6 2.9
Leg predicted mass (right) 1.5 8.0 17.6 -0.4 4.2 2.5
Arm fat mass (left) 0.2 0.9 2.7 -0.2 1.6 0.0
Number of self-reported non-cancer illnesses 0.9 1.5 4.0 0.3 2.0 0.7
Average weekly champagne plus white wine intake 1.4 1.9 3.6 -1.9 0.9 1.1
Miserableness 0.6 1.1 1.6 1.2 1.2 -0.3
Guilty feelings 0.6 0.9 1.6 1.3 0.2 1.0
Wears glasses or contact lenses 0.3 0.3 0.7 -0.5 0.9 0.2
Ever taken oral contraceptive pill 1.7 1.9 3.8 -0.7 2.0 1.2
Hearing aid user 0.4 0.5 1.1 -1.1 0.6 0.3
Mother’s age at death 1.7 2.2 6.4 -2.5 -0.1 0.3
Financial situation satisfaction 0.1 0.1 0.2 0.4 0.3 0.2
Tinnitus: Yes, now most or all of the time 1.7 2.0 5.6 2.4 0.4 0.5
Commuting to job workplace: Public transport 1.1 1.3 2.5 -1.6 1.0 0.6
Eye problems/disorders: Glaucoma 0.2 0.2 0.3 0.4 0.3 0.6
Medication: Blood pressure 0.3 0.6 1.2 -1.1 0.7 0.1
Pain type(s) experienced in last month: Hip pain 2.2 2.7 6.3 2.5 -0.0 -1.4
Supplements: Fish oil (including cod liver oil) 1.0 1.3 2.5 1.6 0.7 0.9
High cholesterol (Self-reported) 0.1 0.3 0.5 -0.2 -0.7 0.5
Medication: Bendroflumethiazide 0.6 0.9 1.6 -0.2 1.0 1.3
Medication: Paracetamol 0.5 0.7 1.7 -1.3 -0.4 -0.6
Medication: Lisinopril 1.2 1.6 2.1 -1.4 0.9 1.5
Medication: Atorvastatin 1.2 1.5 3.1 -1.8 0.6 1.0
Illnesses of father: High blood pressure 0.1 0.1 0.2 0.4 -0.0 -0.2
Alcohol drinker status: Never 0.0 0.0 0.1 0.3 -0.1 -0.1
Ever smoked 0.3 0.5 0.6 -0.8 -0.6 -0.8
Basal metabolic rate 1.6 8.6 18.9 -0.8 4.3 2.5
Leg fat percentage (left) 0.2 0.8 2.4 -0.0 0.0 -1.5
Arm fat-free mass (left) 2.0 10.2 20.2 -1.1 4.5 3.1
Number of operations (self-reported) 1.5 2.3 3.6 -1.9 1.7 0.6
Average weekly beer plus cider intake 0.1 0.2 0.2 0.5 -0.4 -0.3
Irritability 1.5 2.5 6.2 2.5 -1.1 0.0
Risk taking 2.6 3.8 9.8 -3.1 0.3 1.2
Ever had prostate specific antigen (PSA) test 1.4 1.6 2.3 -1.1 1.5 1.2
Fractured/broken bones in last 5 years 1.3 1.7 3.6 1.9 0.1 1.2
Age started oral contraceptive pill 0.6 0.8 1.5 -0.1 -1.0 -1.2
Diastolic blood pressure, automated reading 0.1 0.4 0.7 0.2 -0.7 -0.9
Ever depressed for a whole week 0.3 0.4 0.7 -0.7 0.9 -0.3
Unable to work because of sickness or disability 0.0 0.0 0.1 -0.2 -0.0 -0.2
Commuting to job workplace: Cycle 2.0 2.4 3.8 -1.4 1.2 2.0
Myopia 3.0 4.4 6.6 2.0 -1.6 -2.6
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.0 1.4 -1.0 -0.6
Cholesterol lowering medication 0.2 0.3 0.8 -0.0 -0.9 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.6 -0.2 -0.2 -1.3
Pain experienced in last month 0.4 0.7 2.0 -1.4 -0.3 0.2
Supplements: Calcium 1.3 1.4 2.2 1.5 -1.0 -1.0
Basal cell carcinoma (self-reported) 0.9 1.1 1.9 1.4 -0.5 -1.0
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.4 0.2 -0.6 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.9 0.5 1.4 0.5
Heart disease (siblings) 2.0 2.4 3.3 -1.6 1.1 1.8
Alcohol drinker status: Previous 2.0 2.3 3.6 1.9 -1.2 -1.3
Pack years of smoking 0.3 0.4 0.6 0.4 -0.7 -0.8
Impedance of whole body 1.8 9.0 14.2 1.2 -3.8 -3.4
Leg fat mass (left) 0.2 0.7 2.1 -0.3 1.4 -0.2
Arm predicted mass (left) 1.7 8.6 17.1 -0.9 4.1 2.8