Best TWAS P=9.51e-19 · Best GWAS P=3.13e-18 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CYP51A1 | 0.05 | 0.08 | lasso | 5 | 0.06 | 2.4e-08 | -8.10 | 7.9 | 3.4e-15 | 0.18 | 0.20 | 0.80 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | KRIT1 | 0.04 | 0.01 | blup | 318 | 0.02 | 1.2e-03 | -8.33 | 5.6 | 2.8e-08 | 0.18 | 0.16 | 0.73 | FALSE |
3 | GTEx | Adrenal Gland | GATAD1 | 0.40 | 0.22 | lasso | 7 | 0.25 | 2.0e-09 | -2.56 | 5.5 | 5.1e-08 | 0.42 | 0.65 | 0.10 | TRUE |
4 | GTEx | Artery Aorta | AC000120.7 | 0.06 | 0.09 | lasso | 4 | 0.08 | 3.4e-05 | -8.30 | 8.3 | 1.4e-16 | 0.17 | 0.19 | 0.80 | FALSE |
5 | GTEx | Artery Coronary | AC000120.7 | 0.07 | 0.04 | lasso | 4 | 0.02 | 6.8e-02 | -7.88 | 8.5 | 2.3e-17 | 0.18 | 0.12 | 0.44 | TRUE |
6 | GTEx | Artery Tibial | AC000120.7 | 0.08 | 0.06 | lasso | 4 | 0.06 | 3.2e-05 | -7.67 | 7.8 | 4.4e-15 | 0.24 | 0.25 | 0.74 | FALSE |
7 | GTEx | Brain Cortex | AC000120.7 | 0.12 | 0.08 | enet | 16 | 0.07 | 7.0e-03 | -8.11 | 7.0 | 2.5e-12 | 0.23 | 0.09 | 0.35 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | AC000120.7 | 0.04 | 0.05 | lasso | 4 | 0.04 | 5.2e-04 | -7.91 | 8.3 | 1.0e-16 | 0.16 | 0.20 | 0.76 | FALSE |
9 | GTEx | Colon Sigmoid | AC000120.7 | 0.09 | 0.08 | lasso | 3 | 0.07 | 2.2e-03 | -6.96 | 6.5 | 8.5e-11 | 0.15 | 0.16 | 0.51 | TRUE |
10 | GTEx | Colon Transverse | KRIT1 | 0.32 | 0.00 | lasso | 8 | 0.00 | 3.7e-01 | -8.30 | 7.0 | 3.7e-12 | 0.03 | 0.08 | 0.30 | FALSE |
11 | GTEx | Colon Transverse | AC000120.7 | 0.09 | 0.04 | lasso | 5 | 0.01 | 9.4e-02 | -8.19 | 8.2 | 3.6e-16 | 0.17 | 0.12 | 0.50 | FALSE |
12 | GTEx | Esophagus Mucosa | AKAP9 | 0.04 | 0.03 | lasso | 15 | 0.02 | 2.7e-02 | -8.24 | -8.2 | 2.7e-16 | -0.17 | 0.14 | 0.83 | FALSE |
13 | GTEx | Esophagus Muscularis | FAM133B | 0.07 | 0.01 | enet | 2 | 0.01 | 1.2e-01 | 8.71 | 8.2 | 2.0e-16 | 0.94 | 0.01 | 0.89 | TRUE |
14 | GTEx | Heart Atrial Appendage | AKAP9 | 0.06 | 0.01 | enet | 11 | 0.02 | 4.5e-02 | -7.92 | 8.1 | 5.8e-16 | 0.17 | 0.11 | 0.66 | FALSE |
15 | GTEx | Lung | AC000120.7 | 0.04 | 0.03 | lasso | 3 | 0.01 | 4.8e-02 | -8.17 | 8.2 | 1.5e-16 | 0.17 | 0.16 | 0.65 | FALSE |
16 | GTEx | Muscle Skeletal | CYP51A1 | 0.10 | 0.18 | enet | 21 | 0.17 | 5.0e-16 | -8.30 | 8.4 | 4.8e-17 | 0.19 | 0.10 | 0.90 | FALSE |
17 | GTEx | Muscle Skeletal | AC000120.7 | 0.05 | 0.01 | enet | 10 | 0.01 | 5.4e-02 | -8.25 | 6.1 | 1.2e-09 | 0.15 | 0.14 | 0.49 | TRUE |
18 | GTEx | Nerve Tibial | ANKIB1 | 0.04 | 0.04 | enet | 2 | 0.02 | 8.5e-03 | -7.30 | 8.2 | 2.7e-16 | 0.15 | 0.13 | 0.71 | FALSE |
19 | GTEx | Nerve Tibial | AKAP9 | 0.03 | 0.05 | lasso | 2 | 0.03 | 2.7e-03 | -8.25 | -8.2 | 1.6e-16 | -0.17 | 0.12 | 0.75 | FALSE |
20 | GTEx | Pancreas | AC000120.7 | 0.05 | 0.03 | enet | 12 | 0.02 | 4.4e-02 | -5.53 | 7.0 | 2.8e-12 | 0.21 | 0.14 | 0.53 | FALSE |
21 | GTEx | Prostate | AC000120.7 | 0.13 | 0.09 | lasso | 3 | 0.09 | 2.8e-03 | -8.33 | 8.3 | 1.5e-16 | 0.17 | 0.08 | 0.43 | FALSE |
22 | GTEx | Skin Sun Exposed Lower leg | AC000120.7 | 0.06 | 0.00 | enet | 24 | 0.00 | 7.9e-01 | -4.20 | 5.9 | 4.1e-09 | 0.31 | 0.10 | 0.34 | FALSE |
23 | GTEx | Spleen | PEX1 | 0.18 | 0.00 | enet | 38 | 0.05 | 2.4e-02 | -8.32 | 5.9 | 3.9e-09 | 0.16 | 0.06 | 0.36 | FALSE |
24 | GTEx | Spleen | AC000120.7 | 0.10 | 0.07 | lasso | 5 | 0.04 | 3.9e-02 | -8.17 | 8.2 | 2.3e-16 | 0.17 | 0.09 | 0.45 | FALSE |
25 | GTEx | Testis | AC000120.7 | 0.05 | 0.03 | enet | 24 | 0.01 | 8.5e-02 | -7.74 | 7.0 | 1.7e-12 | 0.15 | 0.12 | 0.60 | FALSE |
26 | GTEx | Thyroid | AC000120.7 | 0.04 | 0.01 | lasso | 6 | 0.02 | 2.2e-02 | -7.13 | 5.9 | 3.7e-09 | 0.16 | 0.17 | 0.51 | TRUE |
27 | ROSMAP | Brain Pre-frontal Cortex | ANKIB1 | 0.03 | 0.03 | enet | 8 | 0.03 | 2.6e-04 | -8.37 | 8.2 | 2.6e-16 | 0.15 | 0.06 | 0.92 | FALSE |
28 | ROSMAP | Brain Pre-frontal Cortex | CYP51A1 | 0.04 | 0.02 | blup | 287 | 0.03 | 4.7e-05 | -7.89 | 5.7 | 9.7e-09 | 0.14 | 0.23 | 0.76 | FALSE |
29 | ROSMAP | Brain Pre-frontal Cortex | KRIT1 | 0.04 | 0.03 | bslmm | 311 | 0.01 | 9.0e-03 | -8.39 | -7.4 | 1.7e-13 | -0.32 | 0.09 | 0.89 | TRUE |
30 | ROSMAP | Brain Pre-frontal Cortex | MTERF | 0.04 | 0.00 | blup | 375 | 0.02 | 7.5e-04 | 0.91 | -5.7 | 1.3e-08 | -0.12 | 0.09 | 0.37 | FALSE |
31 | YFS | Blood | CYP51A1 | 0.03 | 0.06 | blup | 288 | 0.05 | 1.2e-16 | -8.13 | 8.8 | 9.5e-19 | 0.28 | 0.17 | 0.83 | TRUE |
32 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CYP51A1 | 0.01 | 0.02 | blup | 51 | 0.02 | 2.0e-04 | -8.29 | 8.5 | 1.9e-17 | 0.18 | 0.05 | 0.92 | FALSE |
33 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CYP51A1 | 0.07 | 0.04 | lasso | 2 | 0.04 | 4.3e-05 | -8.37 | 8.3 | 1.2e-16 | 0.15 | 0.02 | 0.98 | FALSE |
34 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CYP51A1 | 0.04 | 0.05 | blup | 51 | 0.05 | 9.4e-07 | -8.25 | 8.4 | 4.5e-17 | 0.18 | 0.06 | 0.94 | FALSE |
35 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CYP51A1 | 0.01 | 0.01 | blup | 51 | 0.01 | 1.2e-02 | -8.17 | 8.4 | 4.3e-17 | 0.18 | 0.04 | 0.62 | FALSE |
36 | The Cancer Genome Atlas | Lung Adenocarcinoma | CYP51A1 | 0.03 | 0.03 | enet | 12 | 0.03 | 1.2e-04 | -8.39 | 8.6 | 8.4e-18 | 0.17 | 0.02 | 0.95 | FALSE |
37 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LOC401387 | 0.04 | 0.00 | lasso | 1 | 0.00 | 1.6e-01 | -8.11 | -8.1 | 5.1e-16 | -0.19 | 0.03 | 0.58 | FALSE |
38 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MTERF | 0.03 | 0.03 | blup | 47 | 0.04 | 1.2e-04 | -7.37 | -8.0 | 1.3e-15 | -0.17 | 0.03 | 0.95 | FALSE |