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chr7:90,624,416-92,918,588

Best TWAS P=9.51e-19 · Best GWAS P=3.13e-18 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
31	YFS	Blood	CYP51A1	0.03	0.06	blup	288	0.05	1.2e-16	-8.13	8.8	9.5e-19	0.28	0.17	0.83	TRUE
5	GTEx	Artery Coronary	AC000120.7	0.07	0.04	lasso	4	0.02	6.8e-02	-7.88	8.5	2.3e-17	0.18	0.12	0.44	TRUE
13	GTEx	Esophagus Muscularis	FAM133B	0.07	0.01	enet	2	0.01	1.2e-01	8.71	8.2	2.0e-16	0.94	0.01	0.89	TRUE
29	ROSMAP	Brain Pre-frontal Cortex	KRIT1	0.04	0.03	bslmm	311	0.01	9.0e-03	-8.39	-7.4	1.7e-13	-0.32	0.09	0.89	TRUE
9	GTEx	Colon Sigmoid	AC000120.7	0.09	0.08	lasso	3	0.07	2.2e-03	-6.96	6.5	8.5e-11	0.15	0.16	0.51	TRUE
17	GTEx	Muscle Skeletal	AC000120.7	0.05	0.01	enet	10	0.01	5.4e-02	-8.25	6.1	1.2e-09	0.15	0.14	0.49	TRUE
26	GTEx	Thyroid	AC000120.7	0.04	0.01	lasso	6	0.02	2.2e-02	-7.13	5.9	3.7e-09	0.16	0.17	0.51	TRUE
3	GTEx	Adrenal Gland	GATAD1	0.40	0.22	lasso	7	0.25	2.0e-09	-2.56	5.5	5.1e-08	0.42	0.65	0.10	TRUE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	CYP51A1	0.03	0.03	enet	12	0.03	1.2e-04	-8.39	8.6	8.4e-18	0.17	0.02	0.95	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	CYP51A1	0.01	0.02	blup	51	0.02	2.0e-04	-8.29	8.5	1.9e-17	0.18	0.05	0.92	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	CYP51A1	0.01	0.01	blup	51	0.01	1.2e-02	-8.17	8.4	4.3e-17	0.18	0.04	0.62	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CYP51A1	0.04	0.05	blup	51	0.05	9.4e-07	-8.25	8.4	4.5e-17	0.18	0.06	0.94	FALSE
16	GTEx	Muscle Skeletal	CYP51A1	0.10	0.18	enet	21	0.17	5.0e-16	-8.30	8.4	4.8e-17	0.19	0.10	0.90	FALSE
8	GTEx	Cells Transformed fibroblasts	AC000120.7	0.04	0.05	lasso	4	0.04	5.2e-04	-7.91	8.3	1.0e-16	0.16	0.20	0.76	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CYP51A1	0.07	0.04	lasso	2	0.04	4.3e-05	-8.37	8.3	1.2e-16	0.15	0.02	0.98	FALSE
4	GTEx	Artery Aorta	AC000120.7	0.06	0.09	lasso	4	0.08	3.4e-05	-8.30	8.3	1.4e-16	0.17	0.19	0.80	FALSE
15	GTEx	Lung	AC000120.7	0.04	0.03	lasso	3	0.01	4.8e-02	-8.17	8.2	1.5e-16	0.17	0.16	0.65	FALSE
21	GTEx	Prostate	AC000120.7	0.13	0.09	lasso	3	0.09	2.8e-03	-8.33	8.3	1.5e-16	0.17	0.08	0.43	FALSE
19	GTEx	Nerve Tibial	AKAP9	0.03	0.05	lasso	2	0.03	2.7e-03	-8.25	-8.2	1.6e-16	-0.17	0.12	0.75	FALSE
24	GTEx	Spleen	AC000120.7	0.10	0.07	lasso	5	0.04	3.9e-02	-8.17	8.2	2.3e-16	0.17	0.09	0.45	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	ANKIB1	0.03	0.03	enet	8	0.03	2.6e-04	-8.37	8.2	2.6e-16	0.15	0.06	0.92	FALSE
12	GTEx	Esophagus Mucosa	AKAP9	0.04	0.03	lasso	15	0.02	2.7e-02	-8.24	-8.2	2.7e-16	-0.17	0.14	0.83	FALSE
18	GTEx	Nerve Tibial	ANKIB1	0.04	0.04	enet	2	0.02	8.5e-03	-7.30	8.2	2.7e-16	0.15	0.13	0.71	FALSE
11	GTEx	Colon Transverse	AC000120.7	0.09	0.04	lasso	5	0.01	9.4e-02	-8.19	8.2	3.6e-16	0.17	0.12	0.50	FALSE
37	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LOC401387	0.04	0.00	lasso	1	0.00	1.6e-01	-8.11	-8.1	5.1e-16	-0.19	0.03	0.58	FALSE
14	GTEx	Heart Atrial Appendage	AKAP9	0.06	0.01	enet	11	0.02	4.5e-02	-7.92	8.1	5.8e-16	0.17	0.11	0.66	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	MTERF	0.03	0.03	blup	47	0.04	1.2e-04	-7.37	-8.0	1.3e-15	-0.17	0.03	0.95	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CYP51A1	0.05	0.08	lasso	5	0.06	2.4e-08	-8.10	7.9	3.4e-15	0.18	0.20	0.80	FALSE
6	GTEx	Artery Tibial	AC000120.7	0.08	0.06	lasso	4	0.06	3.2e-05	-7.67	7.8	4.4e-15	0.24	0.25	0.74	FALSE
25	GTEx	Testis	AC000120.7	0.05	0.03	enet	24	0.01	8.5e-02	-7.74	7.0	1.7e-12	0.15	0.12	0.60	FALSE
7	GTEx	Brain Cortex	AC000120.7	0.12	0.08	enet	16	0.07	7.0e-03	-8.11	7.0	2.5e-12	0.23	0.09	0.35	FALSE
20	GTEx	Pancreas	AC000120.7	0.05	0.03	enet	12	0.02	4.4e-02	-5.53	7.0	2.8e-12	0.21	0.14	0.53	FALSE
10	GTEx	Colon Transverse	KRIT1	0.32	0.00	lasso	8	0.00	3.7e-01	-8.30	7.0	3.7e-12	0.03	0.08	0.30	FALSE
23	GTEx	Spleen	PEX1	0.18	0.00	enet	38	0.05	2.4e-02	-8.32	5.9	3.9e-09	0.16	0.06	0.36	FALSE
22	GTEx	Skin Sun Exposed Lower leg	AC000120.7	0.06	0.00	enet	24	0.00	7.9e-01	-4.20	5.9	4.1e-09	0.31	0.10	0.34	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	CYP51A1	0.04	0.02	blup	287	0.03	4.7e-05	-7.89	5.7	9.7e-09	0.14	0.23	0.76	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	MTERF	0.04	0.00	blup	375	0.02	7.5e-04	0.91	-5.7	1.3e-08	-0.12	0.09	0.37	FALSE
2	CommonMind	Brain Pre-frontal Cortex	KRIT1	0.04	0.01	blup	318	0.02	1.2e-03	-8.33	5.6	2.8e-08	0.18	0.16	0.73	FALSE