Hub : Genes

ANKIB1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.0421 0.0251 3.5e-03 0.036 NA 0.023 NA 0.003 1.3e-03 NA 8.5e-03 NA 2.0e-01
2 NTR Blood 0.0231 0.0127 1.9e-03 0.006 0.000 0.004 0.003 0.004 3.5e-03 2.4e-01 1.2e-02 3.8e-02 1.5e-02
3 ROSMAP Brain Pre-frontal Cortex 0.0269 0.0154 4.0e-03 0.031 0.007 0.026 0.005 0.011 6.0e-05 3.7e-02 2.6e-04 6.6e-02 1.3e-02
4 YFS Blood 0.0292 0.0108 4.5e-07 0.031 0.024 0.031 0.028 0.031 1.4e-10 1.9e-08 1.5e-10 1.1e-09 1.8e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.8 1.3 3.4 1.8 -0.2 1.3 -0.3
Bipolar Disorder or Schizophrenia 0.6 1.4 3.3 1.1 -0.7 0.9 -1.8
Depressed Affect (Nagel 2018) 0.2 0.3 0.6 0.7 -0.8 0.1 0.5
Depression (Nagel 2018) 1.7 2.6 4.8 1.8 -0.8 2.2 -1.3
Intelligence (Savage-Jansen 2018) 0.6 1.9 4.9 -1.1 2.2 -1.0 0.8
Neuroticism (Nagel 2018) 0.1 0.2 0.2 -0.3 -0.5 -0.5 -0.3
Schizophrenia (2018) 0.6 1.2 4.4 -0.1 -0.7 0.1 -2.1
Schizophrenia vs Biploar Disorder 2.7 3.6 6.8 -2.6 -1.5 -1.8 -1.5
Worry (Nagel 2018) 0.1 0.1 0.3 0.0 -0.5 -0.1 -0.6
Alzheimer’s Disease (in mother) 2.1 2.4 4.0 1.8 1.1 1.0 2.0
Alzheimer’s Disease (in father) 0.5 0.5 1.0 1.0 0.2 1.0 -0.1
Alzheimer’s Disease (including proxy) 2.9 4.1 7.6 2.8 1.3 1.3 2.4
Crohns Disease (2017) 1.2 2.6 5.1 1.6 -0.9 2.3 -1.4
Irritable Bowel Disease (IBD) 0.3 0.8 1.3 1.1 0.4 0.8 1.1
Ulcerative Colitis (UC) 0.5 0.9 3.2 0.1 0.4 -0.6 1.8
Major Depression (MDD) 3.5 4.2 7.1 2.0 -2.0 2.7 -1.3
Reaction Time 1.1 2.1 4.6 -1.9 0.1 -2.1 -0.7
Verbal and Numeric Reasoning (VNR) 0.7 1.6 3.5 -1.1 1.9 -1.2 0.6
Breast Cancer 5.9 14.2 24.5 4.9 3.2 4.1 2.3
Ovarian Cancer 0.3 0.4 0.8 -0.2 -0.9 -0.2 -0.7
Prostate Cancer 0.9 1.3 2.6 -1.6 0.3 -1.5 0.5
Age at First Birth 0.1 0.1 0.2 -0.4 0.4 -0.1 -0.4
Bipolar Disorder (2011) 0.2 0.2 0.6 0.3 0.8 0.0 -0.2
Body Mass Index (BMI) (2010) 1.4 1.9 3.1 -1.6 0.4 -1.8 1.3
Coronary Artery Disease (CAD) 0.4 0.4 0.9 -0.9 0.1 -0.9 0.2
Crohns Disease (2012) 2.8 4.4 8.0 2.0 -1.5 2.8 -1.9
Mean Putamen Volume 3.3 3.8 7.3 -2.3 1.2 -2.7 1.0
Fasting Glucose 0.5 0.6 1.9 0.6 1.4 0.1 -0.4
HbA1C 0.3 0.3 0.9 0.4 0.9 -0.1 0.4
HDL Cholesterol 1.0 1.7 3.6 0.0 -1.9 0.7 -1.7
LDL Cholesterol 0.4 0.6 1.2 0.5 1.1 0.6 0.8
Lupus 0.5 0.8 1.0 1.0 -0.7 0.9 0.9
Neuroticism (2016) 2.7 3.9 6.5 2.5 -1.1 2.5 -1.4
Primary Biliary Cirrhosis 0.3 0.4 1.1 -1.1 -0.6 -0.4 -0.4
Rheumatoid Arthritis 0.5 0.7 2.0 -0.2 0.1 -0.8 1.4
Schizophrenia (2014) 0.4 0.9 2.3 -0.7 -0.7 -0.7 -1.5
Triglycerides 1.1 1.8 4.0 0.2 2.0 -0.4 1.7
Type 2 Diabetes (T2D) (2012) 1.2 1.4 1.6 -1.2 1.3 -1.3 1.1
Ulcerative Colitis 0.5 0.8 1.5 1.2 0.5 0.9 0.7
Blood Eosinophil Count 1.7 13.2 22.0 -4.7 -3.2 -2.9 -3.5
Blood Platelet Count 0.8 9.3 19.6 4.2 0.4 4.4 -0.2
Blood Red Count 3.5 33.8 67.1 8.2 -0.8 8.2 -0.6
Blood White Count 0.9 6.9 11.3 2.9 -2.7 3.4 -0.4
Heel T-Score 2.0 16.1 38.2 6.2 -0.1 5.1 0.7
BMI 0.0 0.2 0.7 -0.3 -0.2 0.0 -0.9
Height 2.5 48.1 93.7 -9.2 -2.9 -9.7 2.4
Waist Hip Ratio (WHR) 0.5 2.2 4.5 -0.6 -1.9 0.3 -2.1
Systolic Blood Pressure 3.8 19.0 34.5 5.9 -1.3 5.9 -2.3
Smoking Status 1.5 3.5 5.2 -1.6 2.0 -1.6 2.3
Allergy or Eczema 0.5 1.2 2.5 1.0 -0.2 1.6 -1.2
Cardiovascular Disease 1.4 4.5 6.7 2.4 -1.8 2.6 -1.4
Hypothyroidism (self reported) 0.3 0.7 1.7 -0.5 -1.3 -0.8 0.1
Respiratory disease 0.7 1.6 2.6 1.2 -1.6 1.2 -0.8
Type 2 Diabetes (T2D) (2018) 1.3 2.3 4.6 2.1 0.2 2.1 0.5
Lung FEV1/FVC ratio 0.1 0.3 1.1 -0.4 1.0 0.1 0.3
Lung FVC 1.8 9.2 20.2 4.5 1.9 3.1 1.7
Neuroticism 0.2 0.6 1.6 0.2 -1.3 0.1 -0.8
Chronotype (morning person) 2.0 4.5 9.8 3.1 -0.8 2.8 0.2
Hair Pigment 0.5 14.0 24.8 4.6 -2.7 5.0 -1.6
Tanning 0.1 0.6 1.9 0.4 1.4 0.4 0.5
Hand grip strength (left) 0.1 0.2 0.2 -0.5 0.4 -0.5 0.1
Number of treatments/medications taken 0.8 1.5 4.7 2.2 0.1 1.0 0.6
Average weekly spirits intake 0.5 0.6 2.4 0.2 -1.5 0.1 -0.2
Sensitivity / hurt feelings 0.1 0.2 0.3 0.3 -0.4 0.3 -0.5
Frequency of depressed mood in last 2 weeks 2.7 3.7 5.7 1.9 -1.7 2.4 -1.6
Hearing difficulty/problems: Yes 0.4 0.7 2.2 0.2 -1.5 0.0 -0.6
Relative age of first facial hair 1.3 2.8 5.8 -2.0 0.3 -2.4 1.0
Other serious medical condition/disability diagnosed by doctor 2.2 2.8 4.6 1.9 -2.1 1.6 -0.7
Ever used hormone-replacement therapy (HRT) 6.6 8.4 19.4 4.4 -1.8 3.3 -0.3
Ever had hysterectomy (womb removed) 3.7 4.1 6.2 2.5 -1.8 2.4 -1.2
Systolic blood pressure, automated reading 5.1 14.7 25.2 4.9 -1.6 5.0 -2.6
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 1.5 1.2 -0.1 1.1 0.8
Angina 1.6 2.1 5.3 2.3 0.2 1.7 -0.4
Medication for hormone replacement therapy 4.4 4.9 11.7 3.4 0.1 2.2 1.8
Vitamin and mineral supplements 1.3 1.7 4.8 -2.2 -0.2 -1.4 -0.2
Supplements: Zinc 2.5 2.7 5.3 2.2 -0.7 2.3 -0.3
Medication: Co-codamol 0.8 0.9 2.0 1.4 -0.2 1.1 -0.5
Medication: Metformin 2.3 3.2 8.1 2.9 -0.1 2.2 0.3
Diabetes (father) 0.8 0.9 1.4 1.2 1.1 1.0 -0.3
Diabetes (mother) 0.3 0.4 1.4 1.2 0.3 0.5 0.3
Severe depression (siblings) 0.7 0.7 1.7 1.3 0.6 0.9 0.4
Pack years adult smoking proportion 0.0 0.1 0.2 0.2 0.4 0.2 -0.0
Impedance of leg (right) 0.2 0.8 2.0 1.1 -0.3 1.4 -0.4
Leg fat-free mass (left) 1.7 9.1 17.6 -4.2 -1.4 -4.1 -0.1
Trunk fat percentage 0.2 0.6 1.6 0.0 -1.3 0.4 -0.8
Hand grip strength (right) 0.0 0.0 0.0 -0.0 -0.2 -0.2 -0.1
Townsend deprivation index at recruitment 0.8 1.1 3.9 -0.4 -2.0 -0.2 -0.5
Current tobacco smoking 0.3 0.5 1.2 -0.2 0.9 -0.3 1.1
Average weekly fortified wine intake 0.3 0.4 1.2 0.2 -0.2 -0.3 1.1
Maternal smoking around birth 0.8 1.1 3.0 0.0 -1.7 0.0 -1.3
Fed-up feelings 0.4 0.7 1.7 -0.0 -0.0 -1.0 1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.2 0.2 -1.1 0.2 -0.5
Relative age voice broke 0.5 0.8 1.5 -1.1 -0.1 -1.2 0.5
Taking other prescription medications 1.3 2.0 4.7 1.0 -2.2 0.9 -1.2
Age when periods started (menarche) 0.2 0.4 1.1 -0.4 -1.1 -0.6 -0.2
Bilateral oophorectomy (both ovaries removed) 7.6 8.8 17.3 4.2 -1.7 3.9 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.7 6.0 2.5 -0.4 2.1 -0.4
Tinnitus: Yes, but not now, but have in the past 1.0 1.1 2.9 -0.4 -1.7 -0.0 -1.1
Qualifications: CSEs or equivalent 1.9 2.5 6.4 0.1 -2.5 0.5 -1.9
Serious illness, injury or assault to yourself 2.3 2.8 6.7 2.6 -0.5 2.0 -0.3
High blood pressure 1.6 4.4 6.8 2.6 -2.1 2.3 -1.0
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.6 0.3 0.1 0.8 -0.8
Multivitamins +/- minerals 1.6 2.0 5.5 2.4 -0.2 1.5 0.2
Stomach or abdominal pain in last month 4.2 5.3 8.0 2.2 -2.0 2.8 -2.1
Supplements: Glucosamine 0.9 1.2 2.7 1.6 -0.0 1.3 0.5
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 2.7 1.6 -0.7 1.5 -0.3
Medication: Atenolol 0.4 0.5 1.1 1.1 -0.5 0.7 -0.1
Medication: Levothyroxine sodium 1.5 2.5 4.2 -2.1 -1.3 -1.6 -1.3
Sitting height 1.7 11.8 23.6 -4.3 -1.7 -4.9 1.3
Chronic bronchitis/emphysema (father) 0.1 0.1 0.3 -0.1 0.5 0.3 -0.5
High blood pressure (mother) 0.4 0.6 1.7 0.3 -0.6 0.4 -1.3
Body mass index (BMI) 0.0 0.1 0.3 -0.3 0.1 -0.3 -0.5
Impedance of leg (left) 0.4 1.9 4.4 1.7 -0.2 2.1 -0.3
Leg predicted mass (left) 1.7 9.1 17.9 -4.2 -1.4 -4.1 -0.2
Trunk fat mass 0.3 1.1 1.7 -1.3 -1.2 -1.1 -0.5
Waist circumference 0.4 1.4 2.0 -1.4 -1.2 -1.2 -0.8
Number of incorrect matches in round 0.5 0.8 2.0 1.4 -0.3 1.0 0.3
Past tobacco smoking 1.8 3.3 6.2 2.5 -0.5 2.3 -1.0
Alcohol usually taken with meals 3.1 5.1 8.6 2.8 -1.0 2.9 -1.8
Nervous feelings 0.4 0.8 1.7 -1.3 0.1 -1.3 -0.3
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 1.6 1.3 0.1 1.0 -0.4
Hearing difficulty/problems with background noise 0.6 0.9 1.6 -1.2 -0.2 -1.3 0.7
Hair/balding pattern: Pattern 2 0.6 0.8 1.7 -0.7 1.3 -0.2 -0.9
Had menopause 0.1 0.2 0.3 0.4 -0.3 -0.1 0.6
Had other major operations 1.5 1.9 3.2 1.5 -1.1 1.8 -1.0
Forced vital capacity (FVC) 0.1 0.5 1.4 0.7 -0.0 0.4 1.2
Heel bone mineral density (BMD) T-score, automated (right) 2.1 4.8 8.7 3.0 -1.2 2.8 -1.1
Ever unenthusiastic/disinterested for a whole week 2.9 3.6 8.2 2.9 -0.0 2.4 0.7
Qualifications: None of the above 0.7 1.5 2.8 1.7 -0.0 0.7 1.6
Financial difficulties in last 2 years 4.0 5.3 12.9 3.6 0.5 2.5 1.3
Mouth/teeth dental problems 1.1 1.7 3.3 1.8 -1.2 1.4 -0.3
Heart attack 1.0 1.3 2.5 1.3 -0.6 1.6 -0.9
Allergy 0.4 1.0 2.1 -1.3 0.1 -1.4 0.5
Pain all over the body in last month 1.1 1.1 1.6 -1.0 0.8 -1.2 1.3
Diabetes (self-reported) 2.3 3.6 8.1 2.9 -0.1 2.5 0.2
Hayfever/allergic rhinitis (self-reported) 1.4 1.9 2.9 1.7 -1.2 1.6 -0.8
Medication: Ramipril 0.8 1.0 1.8 1.3 -0.3 0.8 -1.2
Medication: Simvastatin 0.3 0.4 1.0 1.0 -0.0 0.6 -0.4
Fluid intelligence score 1.2 2.5 6.0 -1.2 2.5 -1.5 0.8
Illnesses of siblings 0.9 1.2 3.4 -1.8 -0.4 -1.1 -0.1
Neuroticism score 0.2 0.5 0.8 0.6 -0.9 0.5 -0.7
Weight 0.8 4.1 7.3 -2.7 -1.3 -2.7 -0.1
Impedance of arm (right) 0.0 0.2 0.4 0.0 -0.6 0.5 0.4
Arm fat percentage (right) 0.1 0.3 0.8 -0.0 -0.6 0.2 -0.9
Trunk fat-free mass 2.3 13.4 27.5 -4.9 -1.4 -5.2 0.3
Hip circumference 0.4 1.8 3.6 -1.8 -0.6 -1.9 0.2
Time employed in main current job 1.5 1.7 2.0 -1.4 1.4 -1.1 1.3
Alcohol intake versus 10 years previously 2.0 3.0 6.5 2.5 -0.3 2.1 1.0
Father’s age at death 0.9 1.2 3.0 1.7 0.5 1.3 0.2
Worrier / anxious feelings 0.1 0.2 0.5 0.3 -0.7 0.2 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.6 1.3 -0.2 1.1 -0.6
Falls in the last year 0.6 0.8 2.0 0.8 1.4 0.4 0.7
Hair/balding pattern: Pattern 3 0.1 0.1 0.2 -0.4 0.1 -0.1 -0.5
Number of live births 0.1 0.1 0.4 0.2 0.6 0.2 0.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 0.7 0.8 0.2 0.8 0.6
Pulse rate 1.2 2.1 2.6 -1.2 1.6 -1.6 1.3
Happiness 0.9 1.0 2.2 1.4 -0.1 1.5 -0.2
Noisy workplace 2.0 2.5 4.6 2.1 -0.9 2.0 -0.9
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.0 0.7 -0.3 1.0 -0.8
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 1.9 1.4 0.7 1.1 0.9
Mouth/teeth dental problems: Dentures 0.9 1.5 5.0 0.9 0.6 -0.1 2.2
Asthma 0.5 1.0 2.4 1.5 -0.2 1.2 0.4
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.7 -0.7 -0.1 0.1 -0.8
Medication: Cholesterol lowering 1.1 1.7 4.0 2.0 0.4 1.6 -0.1
Depression (self-reported) 0.6 0.7 2.1 1.4 -0.3 0.6 -0.4
Medication: Lansoprazole 5.2 6.0 13.1 3.6 -0.2 3.3 -0.4
Prospective memory result 0.2 0.2 0.6 -0.8 0.6 -0.1 0.0
Lung cancer (father) 0.5 0.6 1.1 -1.0 0.1 -1.1 0.4
Illnesses of mother 0.2 0.2 0.4 -0.6 0.3 -0.3 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.1 0.2 0.7 0.2 1.1
Pulse wave Arterial Stiffness index 0.1 0.2 0.5 -0.1 -0.7 -0.4 0.1
Impedance of arm (left) 0.1 0.7 1.6 0.7 -0.7 1.3 -0.1
Arm fat mass (right) 0.3 1.1 1.9 -1.4 -0.7 -1.2 -0.6
Trunk predicted mass 2.3 13.3 26.9 -4.9 -1.4 -5.2 0.2
Standing height 1.8 17.9 31.8 -5.6 -2.9 -5.5 1.0
Length of working week for main job 1.5 1.6 2.9 1.7 -0.2 1.5 1.2
Exposure to tobacco smoke at home 0.3 0.3 0.7 0.6 -0.8 -0.1 0.4
Breastfed as a baby 0.5 0.6 0.7 0.5 -0.8 0.8 -0.8
Tense / ‘highly strung’ 1.4 2.3 4.4 2.1 -0.5 1.7 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 2.3 3.5 6.4 2.5 -1.8 1.8 -1.2
Hair/balding pattern: Pattern 4 0.4 1.0 2.6 1.6 -0.6 1.0 0.0
Birth weight of first child 1.1 2.0 4.2 -2.0 0.7 -1.6 0.8
Peak expiratory flow (PEF) 2.2 5.1 7.3 2.2 -2.2 2.7 -1.8
Pulse wave reflection index 0.5 0.6 1.0 0.6 -1.0 0.7 -0.7
Ever highly irritable/argumentative for 2 days 1.1 1.3 3.9 0.8 2.0 0.4 0.8
Loud music exposure frequency 1.1 1.2 3.4 -1.0 -0.7 0.2 -1.8
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.5 -1.2 -0.1 -1.0 -0.9
Mouth/teeth dental problems: Bleeding gums 2.8 3.6 6.6 -2.6 -0.8 -1.4 -2.3
Blood clot in the leg (DVT) 0.1 0.2 0.5 0.4 -0.7 0.1 0.1
Medication: Paracetamol 0.8 1.3 1.7 1.1 1.2 1.0 1.3
Headache pain in last month 0.9 1.5 3.9 -0.2 -1.3 0.6 -2.0
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.7 -1.3 -0.3 -0.7 -0.0
Glaucoma (self-reported) 1.2 1.4 3.0 0.1 -1.7 0.3 -1.6
Gout (self-reported) 0.3 0.5 1.3 -1.2 -0.4 -0.6 0.2
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 2.4 -1.3 -0.8 -1.5 0.2
Medication: Amlodipine 0.1 0.1 0.2 -0.4 0.5 -0.4 0.2
Medication: Ventolin 100micrograms inhaler 0.6 0.7 2.2 -0.6 -1.5 -0.4 -0.1
Birth weight 0.1 0.2 0.3 0.5 0.5 0.5 0.5
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.1 0.2 -0.3 0.3 0.4
High blood pressure (siblings) 0.4 0.6 1.5 1.2 0.3 0.8 -0.2
Forced vital capacity (FVC), Best measure 0.1 0.3 1.2 0.2 0.1 0.0 1.1
Body fat percentage 0.1 0.4 0.6 0.3 -0.8 0.5 -0.7
Leg fat percentage (right) 0.0 0.1 0.5 0.2 -0.1 0.2 -0.7
Arm fat-free mass (right) 1.3 6.6 13.0 -3.4 -1.4 -3.6 0.1
Exposure to tobacco smoke outside home 2.8 3.7 6.7 -2.3 0.9 -2.6 1.4
Comparative body size at age 10 1.0 2.9 4.9 -2.2 0.0 -1.6 -2.0
Number of full brothers 0.2 0.3 0.9 -0.9 0.0 -0.5 -0.1
Worry too long after embarrassment 1.3 2.2 3.9 -1.0 -1.9 -0.1 -2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 3.6 4.6 12.6 3.5 0.3 2.3 0.7
Wheeze or whistling in the chest in last year 0.7 1.2 3.2 -0.1 -1.2 0.4 -1.8
Number of children fathered 1.9 2.1 3.1 1.5 -1.1 1.8 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 2.0 2.3 4.5 -2.0 0.4 -2.1 0.6
Age at first live birth 0.6 1.1 2.0 -1.4 1.3 -0.9 -0.2
Pulse wave peak to peak time 0.1 0.1 0.2 -0.4 0.4 -0.1 0.1
Health satisfaction 0.1 0.1 0.2 -0.4 0.3 -0.4 -0.1
Shortness of breath walking on level ground 0.4 0.5 1.4 -1.2 0.2 -0.7 -0.1
Qualifications: College or University degree 0.6 1.8 4.2 -0.0 -1.5 0.9 -2.1
Eye problems/disorders: None of the above 0.8 0.9 2.4 0.1 1.1 -0.3 1.5
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.1 0.2 -0.2 0.1 0.2
Emphysema/chronic bronchitis 0.2 0.2 0.4 0.3 -0.7 0.6 -0.3
Medication for pain relief, constipation, heartburn 0.1 0.2 0.5 -0.7 -0.0 -0.6 -0.1
Neck or shoulder pain in last month 2.1 2.9 5.7 0.9 -2.4 1.2 -2.0
Medication: Blood pressure 0.2 0.3 0.7 0.8 0.3 -0.1 0.8
Angina (self-reported) 2.4 3.2 7.3 2.7 -0.0 2.2 -0.8
Migraine (self-reported) 1.8 2.3 5.9 1.0 -2.4 1.1 -1.0
Medication: Ibuprofen 0.1 0.1 0.1 -0.3 0.1 0.3 -0.3
Medication: Allopurinol 0.0 0.1 0.2 -0.1 -0.4 0.2 -0.0
Medication: Omeprazole 1.0 1.1 3.4 -0.9 -0.4 -0.5 -1.9
Medication: Seretide 50 evohaler 3.0 3.5 7.7 2.8 -0.7 2.2 0.8
Mean time to correctly identify matches 1.1 2.0 3.5 -1.9 -0.7 -1.9 -0.8
Heart disease (mother) 0.5 0.7 1.1 -0.8 0.6 -1.1 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.2 1.1 -0.3 0.8 0.3
Whole body fat mass 0.2 0.9 1.5 -1.2 -0.9 -1.0 -0.6
Leg fat mass (right) 0.2 0.7 1.3 -1.1 -0.5 -1.0 -0.6
Arm predicted mass (right) 1.5 7.6 15.6 -3.6 -1.3 -4.0 0.3
Pulse rate, automated reading 0.8 2.6 4.6 -2.1 -0.5 -1.7 -1.6
Alcohol intake frequency. 1.5 3.6 6.8 2.6 -1.8 2.1 -0.2
Comparative height size at age 10 1.5 8.2 13.5 -3.7 -3.2 -3.0 -0.1
Number of full sisters 0.1 0.1 0.3 0.4 -0.2 -0.1 0.5
Suffer from ‘nerves’ 0.2 0.2 0.6 -0.5 -0.1 -0.7 0.4
Overall health rating 0.9 1.9 4.3 2.1 -0.2 1.8 -0.2
Chest pain or discomfort 0.4 0.6 2.1 -0.1 -0.7 0.2 -1.4
Had major operations 2.8 3.2 6.0 2.5 -1.3 2.1 -0.8
Age at last live birth 0.4 0.6 1.2 -0.9 1.1 0.0 -0.8
Family relationship satisfaction 0.1 0.1 0.2 0.1 -0.2 0.4 -0.3
Leg pain on walking 0.3 0.4 1.4 0.2 0.2 -0.1 1.2
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.4 3.6 -1.2 -0.1 -0.6 -1.9
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.5 1.2 -1.2 0.9 -0.0
Illness, injury, bereavement, stress in last 2 years 2.6 3.2 7.5 -2.7 -0.3 -1.9 -1.3
Medication: Aspirin 0.4 0.6 1.9 1.4 -0.3 0.5 0.1
Supplements: Vitamin C 2.8 3.3 6.5 2.2 -1.0 2.5 -0.9
Knee pain experienced in last month 1.9 2.9 3.4 1.9 -1.6 1.6 -1.7
Hypertension (Self-reported) 2.2 6.0 8.1 2.8 -2.5 2.7 -1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.1 0.5 -0.8 0.6 -1.1
Illnesses of father: Heart disease 0.7 0.9 2.3 -0.1 -1.5 -0.6 -1.0
Illnesses of siblings: Diabetes 2.4 2.9 6.6 2.6 -0.1 2.3 -0.1
Smoking status: Previous 1.0 1.5 2.7 -1.6 0.3 -1.6 0.9
Forced expiratory volume in 1-second (FEV1), predicted 2.4 5.0 9.1 -3.0 -2.2 -2.4 -0.8
Whole body fat-free mass 1.9 11.0 21.3 -4.5 -1.6 -4.6 0.0
Leg fat-free mass (right) 1.5 8.1 15.7 -4.0 -1.4 -3.8 0.0
Arm fat percentage (left) 0.1 0.2 0.6 -0.0 -0.4 0.2 -0.8
Average weekly red wine intake 0.1 0.1 0.3 -0.6 0.5 -0.1 0.1
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.6 -0.8 0.6 -0.7 0.1
Mood swings 0.2 0.3 0.8 -0.0 -0.7 0.1 -0.9
Loneliness, isolation 2.2 3.0 6.3 2.5 -1.4 1.9 0.5
Long-standing illness, disability or infirmity 1.2 1.8 2.6 1.6 -1.4 1.4 -0.9
Ever had bowel cancer screening 0.5 0.6 1.2 0.2 -0.9 0.6 -1.1
Diabetes diagnosed by doctor 1.8 3.0 6.9 2.6 0.2 2.0 1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.3 0.4 1.2 0.2 0.9
Friendships satisfaction 0.0 0.0 0.1 -0.0 -0.2 -0.0 -0.2
Qualifications: nursing, teaching 0.1 0.2 0.2 -0.3 0.5 -0.4 0.5
Commuting to job workplace: Walk 0.5 0.5 1.0 -0.5 1.0 -0.3 0.9
Eye problems/disorders: Cataract 0.2 0.3 0.5 0.6 -0.4 0.7 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 4.6 -0.8 2.2 -0.1 -0.6
Medication for cholesterol 5.0 7.5 12.1 -3.5 2.5 -3.0 1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.1 2.7 -1.3 -0.5 -1.6 0.0
Back pain experienced in last month 1.8 2.6 3.9 1.7 -1.5 2.0 -1.1
Mineral and other dietary supplements 0.4 0.5 1.1 -1.1 0.3 -0.8 0.3
Breast cancer (self-reported) 4.1 4.9 7.2 -2.1 -2.7 -1.2 -2.6
Asthma (self-reported) 0.4 0.7 1.7 1.3 -0.2 0.9 0.6
Osteoporosis (self-reported) 0.3 0.3 1.0 -0.3 -1.0 -0.0 -0.5
Osteoarthritis (self-reported) 0.3 0.4 1.2 1.1 -0.1 0.5 -0.2
Medication: Aspirin 0.7 0.9 3.0 1.7 -0.1 0.8 -0.0
Medication: Gliclazide 1.2 1.3 2.2 1.2 -1.5 1.1 -0.7
Illnesses of father: None of the above (group 1) 0.1 0.1 0.2 0.3 0.1 0.5 0.2
Smoking status: Current 0.3 0.4 0.7 -0.5 0.6 -0.5 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.4 2.8 0.6 1.5 0.1 1.7
Whole body water mass 2.0 11.3 22.1 -4.5 -1.5 -4.7 0.1
Leg predicted mass (right) 1.5 8.0 15.5 -3.9 -1.5 -3.8 -0.1
Arm fat mass (left) 0.2 0.9 1.9 -1.4 -0.6 -1.2 -0.5
Number of self-reported non-cancer illnesses 5.0 8.7 10.8 3.3 -3.3 3.1 -1.9
Average weekly champagne plus white wine intake 1.0 1.3 2.3 -1.1 -1.0 -0.8 -1.5
Miserableness 0.2 0.4 0.8 -0.1 -0.9 -0.2 -0.9
Guilty feelings 3.1 4.6 8.4 -2.9 -1.9 -2.4 -0.9
Wears glasses or contact lenses 2.9 3.4 5.8 -2.3 1.1 -2.4 1.1
Ever taken oral contraceptive pill 3.7 4.2 7.3 2.7 1.5 2.6 0.3
Hearing aid user 0.1 0.1 0.4 0.2 -0.3 0.0 0.6
Mother’s age at death 0.5 0.6 2.2 0.3 1.5 0.2 0.2
Financial situation satisfaction 0.3 0.4 1.0 1.0 -0.1 0.7 0.2
Tinnitus: Yes, now most or all of the time 2.7 3.1 5.7 2.4 1.8 1.6 1.0
Commuting to job workplace: Public transport 1.9 2.3 3.4 -0.8 1.9 -1.7 1.4
Eye problems/disorders: Glaucoma 1.5 1.8 3.8 0.7 -1.2 1.1 -2.0
Medication: Blood pressure 3.9 7.4 9.2 2.4 -2.9 2.5 -3.0
Pain type(s) experienced in last month: Hip pain 3.0 3.8 8.9 3.0 -0.3 2.5 0.1
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.6 0.8 0.4 0.2 0.5
High cholesterol (Self-reported) 0.3 0.5 1.3 1.2 0.4 0.8 0.3
Medication: Bendroflumethiazide 0.1 0.2 0.4 0.6 0.5 0.2 0.4
Medication: Paracetamol 1.1 1.7 2.7 1.6 1.1 1.4 1.1
Medication: Lisinopril 0.2 0.3 0.7 -0.1 -0.6 0.3 -0.8
Medication: Atorvastatin 0.3 0.3 0.7 0.6 0.8 0.5 -0.4
Illnesses of father: High blood pressure 1.3 1.6 2.7 1.0 -1.2 1.1 -1.6
Alcohol drinker status: Never 0.8 1.0 2.2 -0.4 -1.3 -0.0 -1.5
Ever smoked 1.3 2.3 5.3 -2.3 0.8 -1.8 0.5
Basal metabolic rate 1.7 9.4 17.8 -4.2 -1.5 -4.2 -0.1
Leg fat percentage (left) 0.0 0.1 0.3 0.3 0.1 0.4 -0.5
Arm fat-free mass (left) 1.6 8.1 15.1 -3.7 -1.9 -3.9 -0.2
Number of operations (self-reported) 7.7 11.5 15.3 3.9 -3.5 3.6 -2.4
Average weekly beer plus cider intake 1.5 2.2 3.0 -1.4 1.1 -1.6 1.7
Irritability 0.3 0.5 0.9 0.8 1.0 0.6 -0.5
Risk taking 8.3 12.2 13.8 3.6 -3.4 3.7 -3.2
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.3 -0.2 -0.5 -0.3 -0.2
Fractured/broken bones in last 5 years 0.4 0.5 1.2 -1.1 0.5 -0.5 -0.4
Age started oral contraceptive pill 0.5 0.7 2.1 0.2 0.7 -0.2 1.5
Diastolic blood pressure, automated reading 1.5 4.8 8.2 1.0 -2.4 2.0 -2.9
Ever depressed for a whole week 5.7 7.0 13.6 3.7 -1.6 3.4 -0.5
Unable to work because of sickness or disability 0.9 1.2 2.9 0.4 1.2 -0.6 1.7
Commuting to job workplace: Cycle 0.4 0.5 1.5 -0.2 -0.1 -0.7 1.2
Myopia 1.2 1.8 5.7 -0.6 0.3 -1.0 2.4
Vascular/heart problems diagnosed by doctor 1.8 4.9 7.6 -2.8 2.2 -2.3 1.4
Cholesterol lowering medication 0.5 0.8 1.7 0.6 -1.3 0.5 -0.9
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 6.2 -0.2 -0.4 0.3 -2.5
Pain experienced in last month 2.3 3.9 4.6 -1.7 2.1 -1.9 2.1
Supplements: Calcium 0.6 0.7 1.7 0.5 0.9 -0.4 1.3
Basal cell carcinoma (self-reported) 0.8 0.9 2.2 -1.5 0.0 -1.2 0.3
Heart attack/myocardial infarction (self-reported) 0.8 1.0 1.9 1.0 -0.5 1.4 -0.9
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.4 0.6 -0.2 0.2 0.5
Heart disease (siblings) 1.1 1.3 2.4 1.5 -0.6 1.3 -0.8
Alcohol drinker status: Previous 1.4 1.6 2.6 1.6 1.0 1.0 1.4
Pack years of smoking 0.0 0.1 0.2 0.4 0.2 0.2 0.0
Impedance of whole body 0.3 1.8 4.3 1.5 -0.6 2.1 -0.2
Leg fat mass (left) 0.1 0.6 1.1 -1.0 -0.3 -0.9 -0.5
Arm predicted mass (left) 1.6 8.3 15.8 -3.8 -1.7 -4.0 -0.2