Hub : Genes

ANKIB1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.0421	0.0251	3.5e-03	0.036	NA	0.023	NA	0.003	1.3e-03	NA	8.5e-03	NA	2.0e-01
2	NTR	Blood	0.0231	0.0127	1.9e-03	0.006	0.000	0.004	0.003	0.004	3.5e-03	2.4e-01	1.2e-02	3.8e-02	1.5e-02
3	ROSMAP	Brain Pre-frontal Cortex	0.0269	0.0154	4.0e-03	0.031	0.007	0.026	0.005	0.011	6.0e-05	3.7e-02	2.6e-04	6.6e-02	1.3e-02
4	YFS	Blood	0.0292	0.0108	4.5e-07	0.031	0.024	0.031	0.028	0.031	1.4e-10	1.9e-08	1.5e-10	1.1e-09	1.8e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.8	1.3	3.4	1.8	-0.2	1.3	-0.3
Bipolar Disorder or Schizophrenia	0.6	1.4	3.3	1.1	-0.7	0.9	-1.8
Depressed Affect (Nagel 2018)	0.2	0.3	0.6	0.7	-0.8	0.1	0.5
Depression (Nagel 2018)	1.7	2.6	4.8	1.8	-0.8	2.2	-1.3
Intelligence (Savage-Jansen 2018)	0.6	1.9	4.9	-1.1	2.2	-1.0	0.8
Neuroticism (Nagel 2018)	0.1	0.2	0.2	-0.3	-0.5	-0.5	-0.3
Schizophrenia (2018)	0.6	1.2	4.4	-0.1	-0.7	0.1	-2.1
Schizophrenia vs Biploar Disorder	2.7	3.6	6.8	-2.6	-1.5	-1.8	-1.5
Worry (Nagel 2018)	0.1	0.1	0.3	0.0	-0.5	-0.1	-0.6
Alzheimer’s Disease (in mother)	2.1	2.4	4.0	1.8	1.1	1.0	2.0
Alzheimer’s Disease (in father)	0.5	0.5	1.0	1.0	0.2	1.0	-0.1
Alzheimer’s Disease (including proxy)	2.9	4.1	7.6	2.8	1.3	1.3	2.4
Crohns Disease (2017)	1.2	2.6	5.1	1.6	-0.9	2.3	-1.4
Irritable Bowel Disease (IBD)	0.3	0.8	1.3	1.1	0.4	0.8	1.1
Ulcerative Colitis (UC)	0.5	0.9	3.2	0.1	0.4	-0.6	1.8
Major Depression (MDD)	3.5	4.2	7.1	2.0	-2.0	2.7	-1.3
Reaction Time	1.1	2.1	4.6	-1.9	0.1	-2.1	-0.7
Verbal and Numeric Reasoning (VNR)	0.7	1.6	3.5	-1.1	1.9	-1.2	0.6
Breast Cancer	5.9	14.2	24.5	4.9	3.2	4.1	2.3
Ovarian Cancer	0.3	0.4	0.8	-0.2	-0.9	-0.2	-0.7
Prostate Cancer	0.9	1.3	2.6	-1.6	0.3	-1.5	0.5
Age at First Birth	0.1	0.1	0.2	-0.4	0.4	-0.1	-0.4
Bipolar Disorder (2011)	0.2	0.2	0.6	0.3	0.8	0.0	-0.2
Body Mass Index (BMI) (2010)	1.4	1.9	3.1	-1.6	0.4	-1.8	1.3
Coronary Artery Disease (CAD)	0.4	0.4	0.9	-0.9	0.1	-0.9	0.2
Crohns Disease (2012)	2.8	4.4	8.0	2.0	-1.5	2.8	-1.9
Mean Putamen Volume	3.3	3.8	7.3	-2.3	1.2	-2.7	1.0
Fasting Glucose	0.5	0.6	1.9	0.6	1.4	0.1	-0.4
HbA1C	0.3	0.3	0.9	0.4	0.9	-0.1	0.4
HDL Cholesterol	1.0	1.7	3.6	0.0	-1.9	0.7	-1.7
LDL Cholesterol	0.4	0.6	1.2	0.5	1.1	0.6	0.8
Lupus	0.5	0.8	1.0	1.0	-0.7	0.9	0.9
Neuroticism (2016)	2.7	3.9	6.5	2.5	-1.1	2.5	-1.4
Primary Biliary Cirrhosis	0.3	0.4	1.1	-1.1	-0.6	-0.4	-0.4
Rheumatoid Arthritis	0.5	0.7	2.0	-0.2	0.1	-0.8	1.4
Schizophrenia (2014)	0.4	0.9	2.3	-0.7	-0.7	-0.7	-1.5
Triglycerides	1.1	1.8	4.0	0.2	2.0	-0.4	1.7
Type 2 Diabetes (T2D) (2012)	1.2	1.4	1.6	-1.2	1.3	-1.3	1.1
Ulcerative Colitis	0.5	0.8	1.5	1.2	0.5	0.9	0.7
Blood Eosinophil Count	1.7	13.2	22.0	-4.7	-3.2	-2.9	-3.5
Blood Platelet Count	0.8	9.3	19.6	4.2	0.4	4.4	-0.2
Blood Red Count	3.5	33.8	67.1	8.2	-0.8	8.2	-0.6
Blood White Count	0.9	6.9	11.3	2.9	-2.7	3.4	-0.4
Heel T-Score	2.0	16.1	38.2	6.2	-0.1	5.1	0.7
BMI	0.0	0.2	0.7	-0.3	-0.2	0.0	-0.9
Height	2.5	48.1	93.7	-9.2	-2.9	-9.7	2.4
Waist Hip Ratio (WHR)	0.5	2.2	4.5	-0.6	-1.9	0.3	-2.1
Systolic Blood Pressure	3.8	19.0	34.5	5.9	-1.3	5.9	-2.3
Smoking Status	1.5	3.5	5.2	-1.6	2.0	-1.6	2.3
Allergy or Eczema	0.5	1.2	2.5	1.0	-0.2	1.6	-1.2
Cardiovascular Disease	1.4	4.5	6.7	2.4	-1.8	2.6	-1.4
Hypothyroidism (self reported)	0.3	0.7	1.7	-0.5	-1.3	-0.8	0.1
Respiratory disease	0.7	1.6	2.6	1.2	-1.6	1.2	-0.8
Type 2 Diabetes (T2D) (2018)	1.3	2.3	4.6	2.1	0.2	2.1	0.5
Lung FEV1/FVC ratio	0.1	0.3	1.1	-0.4	1.0	0.1	0.3
Lung FVC	1.8	9.2	20.2	4.5	1.9	3.1	1.7
Neuroticism	0.2	0.6	1.6	0.2	-1.3	0.1	-0.8
Chronotype (morning person)	2.0	4.5	9.8	3.1	-0.8	2.8	0.2
Hair Pigment	0.5	14.0	24.8	4.6	-2.7	5.0	-1.6
Tanning	0.1	0.6	1.9	0.4	1.4	0.4	0.5
Hand grip strength (left)	0.1	0.2	0.2	-0.5	0.4	-0.5	0.1
Number of treatments/medications taken	0.8	1.5	4.7	2.2	0.1	1.0	0.6
Average weekly spirits intake	0.5	0.6	2.4	0.2	-1.5	0.1	-0.2
Sensitivity / hurt feelings	0.1	0.2	0.3	0.3	-0.4	0.3	-0.5
Frequency of depressed mood in last 2 weeks	2.7	3.7	5.7	1.9	-1.7	2.4	-1.6
Hearing difficulty/problems: Yes	0.4	0.7	2.2	0.2	-1.5	0.0	-0.6
Relative age of first facial hair	1.3	2.8	5.8	-2.0	0.3	-2.4	1.0
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	4.6	1.9	-2.1	1.6	-0.7
Ever used hormone-replacement therapy (HRT)	6.6	8.4	19.4	4.4	-1.8	3.3	-0.3
Ever had hysterectomy (womb removed)	3.7	4.1	6.2	2.5	-1.8	2.4	-1.2
Systolic blood pressure, automated reading	5.1	14.7	25.2	4.9	-1.6	5.0	-2.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.5	1.2	-0.1	1.1	0.8
Angina	1.6	2.1	5.3	2.3	0.2	1.7	-0.4
Medication for hormone replacement therapy	4.4	4.9	11.7	3.4	0.1	2.2	1.8
Vitamin and mineral supplements	1.3	1.7	4.8	-2.2	-0.2	-1.4	-0.2
Supplements: Zinc	2.5	2.7	5.3	2.2	-0.7	2.3	-0.3
Medication: Co-codamol	0.8	0.9	2.0	1.4	-0.2	1.1	-0.5
Medication: Metformin	2.3	3.2	8.1	2.9	-0.1	2.2	0.3
Diabetes (father)	0.8	0.9	1.4	1.2	1.1	1.0	-0.3
Diabetes (mother)	0.3	0.4	1.4	1.2	0.3	0.5	0.3
Severe depression (siblings)	0.7	0.7	1.7	1.3	0.6	0.9	0.4
Pack years adult smoking proportion	0.0	0.1	0.2	0.2	0.4	0.2	-0.0
Impedance of leg (right)	0.2	0.8	2.0	1.1	-0.3	1.4	-0.4
Leg fat-free mass (left)	1.7	9.1	17.6	-4.2	-1.4	-4.1	-0.1
Trunk fat percentage	0.2	0.6	1.6	0.0	-1.3	0.4	-0.8
Hand grip strength (right)	0.0	0.0	0.0	-0.0	-0.2	-0.2	-0.1
Townsend deprivation index at recruitment	0.8	1.1	3.9	-0.4	-2.0	-0.2	-0.5
Current tobacco smoking	0.3	0.5	1.2	-0.2	0.9	-0.3	1.1
Average weekly fortified wine intake	0.3	0.4	1.2	0.2	-0.2	-0.3	1.1
Maternal smoking around birth	0.8	1.1	3.0	0.0	-1.7	0.0	-1.3
Fed-up feelings	0.4	0.7	1.7	-0.0	-0.0	-1.0	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.2	0.2	-1.1	0.2	-0.5
Relative age voice broke	0.5	0.8	1.5	-1.1	-0.1	-1.2	0.5
Taking other prescription medications	1.3	2.0	4.7	1.0	-2.2	0.9	-1.2
Age when periods started (menarche)	0.2	0.4	1.1	-0.4	-1.1	-0.6	-0.2
Bilateral oophorectomy (both ovaries removed)	7.6	8.8	17.3	4.2	-1.7	3.9	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	6.0	2.5	-0.4	2.1	-0.4
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.9	-0.4	-1.7	-0.0	-1.1
Qualifications: CSEs or equivalent	1.9	2.5	6.4	0.1	-2.5	0.5	-1.9
Serious illness, injury or assault to yourself	2.3	2.8	6.7	2.6	-0.5	2.0	-0.3
High blood pressure	1.6	4.4	6.8	2.6	-2.1	2.3	-1.0
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.6	0.3	0.1	0.8	-0.8
Multivitamins +/- minerals	1.6	2.0	5.5	2.4	-0.2	1.5	0.2
Stomach or abdominal pain in last month	4.2	5.3	8.0	2.2	-2.0	2.8	-2.1
Supplements: Glucosamine	0.9	1.2	2.7	1.6	-0.0	1.3	0.5
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.7	1.6	-0.7	1.5	-0.3
Medication: Atenolol	0.4	0.5	1.1	1.1	-0.5	0.7	-0.1
Medication: Levothyroxine sodium	1.5	2.5	4.2	-2.1	-1.3	-1.6	-1.3
Sitting height	1.7	11.8	23.6	-4.3	-1.7	-4.9	1.3
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.1	0.5	0.3	-0.5
High blood pressure (mother)	0.4	0.6	1.7	0.3	-0.6	0.4	-1.3
Body mass index (BMI)	0.0	0.1	0.3	-0.3	0.1	-0.3	-0.5
Impedance of leg (left)	0.4	1.9	4.4	1.7	-0.2	2.1	-0.3
Leg predicted mass (left)	1.7	9.1	17.9	-4.2	-1.4	-4.1	-0.2
Trunk fat mass	0.3	1.1	1.7	-1.3	-1.2	-1.1	-0.5
Waist circumference	0.4	1.4	2.0	-1.4	-1.2	-1.2	-0.8
Number of incorrect matches in round	0.5	0.8	2.0	1.4	-0.3	1.0	0.3
Past tobacco smoking	1.8	3.3	6.2	2.5	-0.5	2.3	-1.0
Alcohol usually taken with meals	3.1	5.1	8.6	2.8	-1.0	2.9	-1.8
Nervous feelings	0.4	0.8	1.7	-1.3	0.1	-1.3	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.6	1.3	0.1	1.0	-0.4
Hearing difficulty/problems with background noise	0.6	0.9	1.6	-1.2	-0.2	-1.3	0.7
Hair/balding pattern: Pattern 2	0.6	0.8	1.7	-0.7	1.3	-0.2	-0.9
Had menopause	0.1	0.2	0.3	0.4	-0.3	-0.1	0.6
Had other major operations	1.5	1.9	3.2	1.5	-1.1	1.8	-1.0
Forced vital capacity (FVC)	0.1	0.5	1.4	0.7	-0.0	0.4	1.2
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.8	8.7	3.0	-1.2	2.8	-1.1
Ever unenthusiastic/disinterested for a whole week	2.9	3.6	8.2	2.9	-0.0	2.4	0.7
Qualifications: None of the above	0.7	1.5	2.8	1.7	-0.0	0.7	1.6
Financial difficulties in last 2 years	4.0	5.3	12.9	3.6	0.5	2.5	1.3
Mouth/teeth dental problems	1.1	1.7	3.3	1.8	-1.2	1.4	-0.3
Heart attack	1.0	1.3	2.5	1.3	-0.6	1.6	-0.9
Allergy	0.4	1.0	2.1	-1.3	0.1	-1.4	0.5
Pain all over the body in last month	1.1	1.1	1.6	-1.0	0.8	-1.2	1.3
Diabetes (self-reported)	2.3	3.6	8.1	2.9	-0.1	2.5	0.2
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	2.9	1.7	-1.2	1.6	-0.8
Medication: Ramipril	0.8	1.0	1.8	1.3	-0.3	0.8	-1.2
Medication: Simvastatin	0.3	0.4	1.0	1.0	-0.0	0.6	-0.4
Fluid intelligence score	1.2	2.5	6.0	-1.2	2.5	-1.5	0.8
Illnesses of siblings	0.9	1.2	3.4	-1.8	-0.4	-1.1	-0.1
Neuroticism score	0.2	0.5	0.8	0.6	-0.9	0.5	-0.7
Weight	0.8	4.1	7.3	-2.7	-1.3	-2.7	-0.1
Impedance of arm (right)	0.0	0.2	0.4	0.0	-0.6	0.5	0.4
Arm fat percentage (right)	0.1	0.3	0.8	-0.0	-0.6	0.2	-0.9
Trunk fat-free mass	2.3	13.4	27.5	-4.9	-1.4	-5.2	0.3
Hip circumference	0.4	1.8	3.6	-1.8	-0.6	-1.9	0.2
Time employed in main current job	1.5	1.7	2.0	-1.4	1.4	-1.1	1.3
Alcohol intake versus 10 years previously	2.0	3.0	6.5	2.5	-0.3	2.1	1.0
Father’s age at death	0.9	1.2	3.0	1.7	0.5	1.3	0.2
Worrier / anxious feelings	0.1	0.2	0.5	0.3	-0.7	0.2	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.6	1.3	-0.2	1.1	-0.6
Falls in the last year	0.6	0.8	2.0	0.8	1.4	0.4	0.7
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.4	0.1	-0.1	-0.5
Number of live births	0.1	0.1	0.4	0.2	0.6	0.2	0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.7	0.8	0.2	0.8	0.6
Pulse rate	1.2	2.1	2.6	-1.2	1.6	-1.6	1.3
Happiness	0.9	1.0	2.2	1.4	-0.1	1.5	-0.2
Noisy workplace	2.0	2.5	4.6	2.1	-0.9	2.0	-0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.0	0.7	-0.3	1.0	-0.8
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	1.9	1.4	0.7	1.1	0.9
Mouth/teeth dental problems: Dentures	0.9	1.5	5.0	0.9	0.6	-0.1	2.2
Asthma	0.5	1.0	2.4	1.5	-0.2	1.2	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.7	-0.7	-0.1	0.1	-0.8
Medication: Cholesterol lowering	1.1	1.7	4.0	2.0	0.4	1.6	-0.1
Depression (self-reported)	0.6	0.7	2.1	1.4	-0.3	0.6	-0.4
Medication: Lansoprazole	5.2	6.0	13.1	3.6	-0.2	3.3	-0.4
Prospective memory result	0.2	0.2	0.6	-0.8	0.6	-0.1	0.0
Lung cancer (father)	0.5	0.6	1.1	-1.0	0.1	-1.1	0.4
Illnesses of mother	0.2	0.2	0.4	-0.6	0.3	-0.3	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.1	0.2	0.7	0.2	1.1
Pulse wave Arterial Stiffness index	0.1	0.2	0.5	-0.1	-0.7	-0.4	0.1
Impedance of arm (left)	0.1	0.7	1.6	0.7	-0.7	1.3	-0.1
Arm fat mass (right)	0.3	1.1	1.9	-1.4	-0.7	-1.2	-0.6
Trunk predicted mass	2.3	13.3	26.9	-4.9	-1.4	-5.2	0.2
Standing height	1.8	17.9	31.8	-5.6	-2.9	-5.5	1.0
Length of working week for main job	1.5	1.6	2.9	1.7	-0.2	1.5	1.2
Exposure to tobacco smoke at home	0.3	0.3	0.7	0.6	-0.8	-0.1	0.4
Breastfed as a baby	0.5	0.6	0.7	0.5	-0.8	0.8	-0.8
Tense / ‘highly strung’	1.4	2.3	4.4	2.1	-0.5	1.7	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.5	6.4	2.5	-1.8	1.8	-1.2
Hair/balding pattern: Pattern 4	0.4	1.0	2.6	1.6	-0.6	1.0	0.0
Birth weight of first child	1.1	2.0	4.2	-2.0	0.7	-1.6	0.8
Peak expiratory flow (PEF)	2.2	5.1	7.3	2.2	-2.2	2.7	-1.8
Pulse wave reflection index	0.5	0.6	1.0	0.6	-1.0	0.7	-0.7
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.9	0.8	2.0	0.4	0.8
Loud music exposure frequency	1.1	1.2	3.4	-1.0	-0.7	0.2	-1.8
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.5	-1.2	-0.1	-1.0	-0.9
Mouth/teeth dental problems: Bleeding gums	2.8	3.6	6.6	-2.6	-0.8	-1.4	-2.3
Blood clot in the leg (DVT)	0.1	0.2	0.5	0.4	-0.7	0.1	0.1
Medication: Paracetamol	0.8	1.3	1.7	1.1	1.2	1.0	1.3
Headache pain in last month	0.9	1.5	3.9	-0.2	-1.3	0.6	-2.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.7	-1.3	-0.3	-0.7	-0.0
Glaucoma (self-reported)	1.2	1.4	3.0	0.1	-1.7	0.3	-1.6
Gout (self-reported)	0.3	0.5	1.3	-1.2	-0.4	-0.6	0.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.4	-1.3	-0.8	-1.5	0.2
Medication: Amlodipine	0.1	0.1	0.2	-0.4	0.5	-0.4	0.2
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.2	-0.6	-1.5	-0.4	-0.1
Birth weight	0.1	0.2	0.3	0.5	0.5	0.5	0.5
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	0.2	-0.3	0.3	0.4
High blood pressure (siblings)	0.4	0.6	1.5	1.2	0.3	0.8	-0.2
Forced vital capacity (FVC), Best measure	0.1	0.3	1.2	0.2	0.1	0.0	1.1
Body fat percentage	0.1	0.4	0.6	0.3	-0.8	0.5	-0.7
Leg fat percentage (right)	0.0	0.1	0.5	0.2	-0.1	0.2	-0.7
Arm fat-free mass (right)	1.3	6.6	13.0	-3.4	-1.4	-3.6	0.1
Exposure to tobacco smoke outside home	2.8	3.7	6.7	-2.3	0.9	-2.6	1.4
Comparative body size at age 10	1.0	2.9	4.9	-2.2	0.0	-1.6	-2.0
Number of full brothers	0.2	0.3	0.9	-0.9	0.0	-0.5	-0.1
Worry too long after embarrassment	1.3	2.2	3.9	-1.0	-1.9	-0.1	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	3.6	4.6	12.6	3.5	0.3	2.3	0.7
Wheeze or whistling in the chest in last year	0.7	1.2	3.2	-0.1	-1.2	0.4	-1.8
Number of children fathered	1.9	2.1	3.1	1.5	-1.1	1.8	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	4.5	-2.0	0.4	-2.1	0.6
Age at first live birth	0.6	1.1	2.0	-1.4	1.3	-0.9	-0.2
Pulse wave peak to peak time	0.1	0.1	0.2	-0.4	0.4	-0.1	0.1
Health satisfaction	0.1	0.1	0.2	-0.4	0.3	-0.4	-0.1
Shortness of breath walking on level ground	0.4	0.5	1.4	-1.2	0.2	-0.7	-0.1
Qualifications: College or University degree	0.6	1.8	4.2	-0.0	-1.5	0.9	-2.1
Eye problems/disorders: None of the above	0.8	0.9	2.4	0.1	1.1	-0.3	1.5
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	0.2	-0.2	0.1	0.2
Emphysema/chronic bronchitis	0.2	0.2	0.4	0.3	-0.7	0.6	-0.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	-0.7	-0.0	-0.6	-0.1
Neck or shoulder pain in last month	2.1	2.9	5.7	0.9	-2.4	1.2	-2.0
Medication: Blood pressure	0.2	0.3	0.7	0.8	0.3	-0.1	0.8
Angina (self-reported)	2.4	3.2	7.3	2.7	-0.0	2.2	-0.8
Migraine (self-reported)	1.8	2.3	5.9	1.0	-2.4	1.1	-1.0
Medication: Ibuprofen	0.1	0.1	0.1	-0.3	0.1	0.3	-0.3
Medication: Allopurinol	0.0	0.1	0.2	-0.1	-0.4	0.2	-0.0
Medication: Omeprazole	1.0	1.1	3.4	-0.9	-0.4	-0.5	-1.9
Medication: Seretide 50 evohaler	3.0	3.5	7.7	2.8	-0.7	2.2	0.8
Mean time to correctly identify matches	1.1	2.0	3.5	-1.9	-0.7	-1.9	-0.8
Heart disease (mother)	0.5	0.7	1.1	-0.8	0.6	-1.1	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.2	1.1	-0.3	0.8	0.3
Whole body fat mass	0.2	0.9	1.5	-1.2	-0.9	-1.0	-0.6
Leg fat mass (right)	0.2	0.7	1.3	-1.1	-0.5	-1.0	-0.6
Arm predicted mass (right)	1.5	7.6	15.6	-3.6	-1.3	-4.0	0.3
Pulse rate, automated reading	0.8	2.6	4.6	-2.1	-0.5	-1.7	-1.6
Alcohol intake frequency.	1.5	3.6	6.8	2.6	-1.8	2.1	-0.2
Comparative height size at age 10	1.5	8.2	13.5	-3.7	-3.2	-3.0	-0.1
Number of full sisters	0.1	0.1	0.3	0.4	-0.2	-0.1	0.5
Suffer from ‘nerves’	0.2	0.2	0.6	-0.5	-0.1	-0.7	0.4
Overall health rating	0.9	1.9	4.3	2.1	-0.2	1.8	-0.2
Chest pain or discomfort	0.4	0.6	2.1	-0.1	-0.7	0.2	-1.4
Had major operations	2.8	3.2	6.0	2.5	-1.3	2.1	-0.8
Age at last live birth	0.4	0.6	1.2	-0.9	1.1	0.0	-0.8
Family relationship satisfaction	0.1	0.1	0.2	0.1	-0.2	0.4	-0.3
Leg pain on walking	0.3	0.4	1.4	0.2	0.2	-0.1	1.2
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	3.6	-1.2	-0.1	-0.6	-1.9
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.5	1.2	-1.2	0.9	-0.0
Illness, injury, bereavement, stress in last 2 years	2.6	3.2	7.5	-2.7	-0.3	-1.9	-1.3
Medication: Aspirin	0.4	0.6	1.9	1.4	-0.3	0.5	0.1
Supplements: Vitamin C	2.8	3.3	6.5	2.2	-1.0	2.5	-0.9
Knee pain experienced in last month	1.9	2.9	3.4	1.9	-1.6	1.6	-1.7
Hypertension (Self-reported)	2.2	6.0	8.1	2.8	-2.5	2.7	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	0.5	-0.8	0.6	-1.1
Illnesses of father: Heart disease	0.7	0.9	2.3	-0.1	-1.5	-0.6	-1.0
Illnesses of siblings: Diabetes	2.4	2.9	6.6	2.6	-0.1	2.3	-0.1
Smoking status: Previous	1.0	1.5	2.7	-1.6	0.3	-1.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	9.1	-3.0	-2.2	-2.4	-0.8
Whole body fat-free mass	1.9	11.0	21.3	-4.5	-1.6	-4.6	0.0
Leg fat-free mass (right)	1.5	8.1	15.7	-4.0	-1.4	-3.8	0.0
Arm fat percentage (left)	0.1	0.2	0.6	-0.0	-0.4	0.2	-0.8
Average weekly red wine intake	0.1	0.1	0.3	-0.6	0.5	-0.1	0.1
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.6	-0.8	0.6	-0.7	0.1
Mood swings	0.2	0.3	0.8	-0.0	-0.7	0.1	-0.9
Loneliness, isolation	2.2	3.0	6.3	2.5	-1.4	1.9	0.5
Long-standing illness, disability or infirmity	1.2	1.8	2.6	1.6	-1.4	1.4	-0.9
Ever had bowel cancer screening	0.5	0.6	1.2	0.2	-0.9	0.6	-1.1
Diabetes diagnosed by doctor	1.8	3.0	6.9	2.6	0.2	2.0	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.3	0.4	1.2	0.2	0.9
Friendships satisfaction	0.0	0.0	0.1	-0.0	-0.2	-0.0	-0.2
Qualifications: nursing, teaching	0.1	0.2	0.2	-0.3	0.5	-0.4	0.5
Commuting to job workplace: Walk	0.5	0.5	1.0	-0.5	1.0	-0.3	0.9
Eye problems/disorders: Cataract	0.2	0.3	0.5	0.6	-0.4	0.7	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	4.6	-0.8	2.2	-0.1	-0.6
Medication for cholesterol	5.0	7.5	12.1	-3.5	2.5	-3.0	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.7	-1.3	-0.5	-1.6	0.0
Back pain experienced in last month	1.8	2.6	3.9	1.7	-1.5	2.0	-1.1
Mineral and other dietary supplements	0.4	0.5	1.1	-1.1	0.3	-0.8	0.3
Breast cancer (self-reported)	4.1	4.9	7.2	-2.1	-2.7	-1.2	-2.6
Asthma (self-reported)	0.4	0.7	1.7	1.3	-0.2	0.9	0.6
Osteoporosis (self-reported)	0.3	0.3	1.0	-0.3	-1.0	-0.0	-0.5
Osteoarthritis (self-reported)	0.3	0.4	1.2	1.1	-0.1	0.5	-0.2
Medication: Aspirin	0.7	0.9	3.0	1.7	-0.1	0.8	-0.0
Medication: Gliclazide	1.2	1.3	2.2	1.2	-1.5	1.1	-0.7
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	0.3	0.1	0.5	0.2
Smoking status: Current	0.3	0.4	0.7	-0.5	0.6	-0.5	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	2.8	0.6	1.5	0.1	1.7
Whole body water mass	2.0	11.3	22.1	-4.5	-1.5	-4.7	0.1
Leg predicted mass (right)	1.5	8.0	15.5	-3.9	-1.5	-3.8	-0.1
Arm fat mass (left)	0.2	0.9	1.9	-1.4	-0.6	-1.2	-0.5
Number of self-reported non-cancer illnesses	5.0	8.7	10.8	3.3	-3.3	3.1	-1.9
Average weekly champagne plus white wine intake	1.0	1.3	2.3	-1.1	-1.0	-0.8	-1.5
Miserableness	0.2	0.4	0.8	-0.1	-0.9	-0.2	-0.9
Guilty feelings	3.1	4.6	8.4	-2.9	-1.9	-2.4	-0.9
Wears glasses or contact lenses	2.9	3.4	5.8	-2.3	1.1	-2.4	1.1
Ever taken oral contraceptive pill	3.7	4.2	7.3	2.7	1.5	2.6	0.3
Hearing aid user	0.1	0.1	0.4	0.2	-0.3	0.0	0.6
Mother’s age at death	0.5	0.6	2.2	0.3	1.5	0.2	0.2
Financial situation satisfaction	0.3	0.4	1.0	1.0	-0.1	0.7	0.2
Tinnitus: Yes, now most or all of the time	2.7	3.1	5.7	2.4	1.8	1.6	1.0
Commuting to job workplace: Public transport	1.9	2.3	3.4	-0.8	1.9	-1.7	1.4
Eye problems/disorders: Glaucoma	1.5	1.8	3.8	0.7	-1.2	1.1	-2.0
Medication: Blood pressure	3.9	7.4	9.2	2.4	-2.9	2.5	-3.0
Pain type(s) experienced in last month: Hip pain	3.0	3.8	8.9	3.0	-0.3	2.5	0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.6	0.8	0.4	0.2	0.5
High cholesterol (Self-reported)	0.3	0.5	1.3	1.2	0.4	0.8	0.3
Medication: Bendroflumethiazide	0.1	0.2	0.4	0.6	0.5	0.2	0.4
Medication: Paracetamol	1.1	1.7	2.7	1.6	1.1	1.4	1.1
Medication: Lisinopril	0.2	0.3	0.7	-0.1	-0.6	0.3	-0.8
Medication: Atorvastatin	0.3	0.3	0.7	0.6	0.8	0.5	-0.4
Illnesses of father: High blood pressure	1.3	1.6	2.7	1.0	-1.2	1.1	-1.6
Alcohol drinker status: Never	0.8	1.0	2.2	-0.4	-1.3	-0.0	-1.5
Ever smoked	1.3	2.3	5.3	-2.3	0.8	-1.8	0.5
Basal metabolic rate	1.7	9.4	17.8	-4.2	-1.5	-4.2	-0.1
Leg fat percentage (left)	0.0	0.1	0.3	0.3	0.1	0.4	-0.5
Arm fat-free mass (left)	1.6	8.1	15.1	-3.7	-1.9	-3.9	-0.2
Number of operations (self-reported)	7.7	11.5	15.3	3.9	-3.5	3.6	-2.4
Average weekly beer plus cider intake	1.5	2.2	3.0	-1.4	1.1	-1.6	1.7
Irritability	0.3	0.5	0.9	0.8	1.0	0.6	-0.5
Risk taking	8.3	12.2	13.8	3.6	-3.4	3.7	-3.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.2	-0.5	-0.3	-0.2
Fractured/broken bones in last 5 years	0.4	0.5	1.2	-1.1	0.5	-0.5	-0.4
Age started oral contraceptive pill	0.5	0.7	2.1	0.2	0.7	-0.2	1.5
Diastolic blood pressure, automated reading	1.5	4.8	8.2	1.0	-2.4	2.0	-2.9
Ever depressed for a whole week	5.7	7.0	13.6	3.7	-1.6	3.4	-0.5
Unable to work because of sickness or disability	0.9	1.2	2.9	0.4	1.2	-0.6	1.7
Commuting to job workplace: Cycle	0.4	0.5	1.5	-0.2	-0.1	-0.7	1.2
Myopia	1.2	1.8	5.7	-0.6	0.3	-1.0	2.4
Vascular/heart problems diagnosed by doctor	1.8	4.9	7.6	-2.8	2.2	-2.3	1.4
Cholesterol lowering medication	0.5	0.8	1.7	0.6	-1.3	0.5	-0.9
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	6.2	-0.2	-0.4	0.3	-2.5
Pain experienced in last month	2.3	3.9	4.6	-1.7	2.1	-1.9	2.1
Supplements: Calcium	0.6	0.7	1.7	0.5	0.9	-0.4	1.3
Basal cell carcinoma (self-reported)	0.8	0.9	2.2	-1.5	0.0	-1.2	0.3
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.9	1.0	-0.5	1.4	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	0.6	-0.2	0.2	0.5
Heart disease (siblings)	1.1	1.3	2.4	1.5	-0.6	1.3	-0.8
Alcohol drinker status: Previous	1.4	1.6	2.6	1.6	1.0	1.0	1.4
Pack years of smoking	0.0	0.1	0.2	0.4	0.2	0.2	0.0
Impedance of whole body	0.3	1.8	4.3	1.5	-0.6	2.1	-0.2
Leg fat mass (left)	0.1	0.6	1.1	-1.0	-0.3	-0.9	-0.5
Arm predicted mass (left)	1.6	8.3	15.8	-3.8	-1.7	-4.0	-0.2