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chr12:47,358,286-49,876,065

Best TWAS P=1.04e-43 · Best GWAS P=3.09e-38 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	GTEx	Brain Frontal Cortex BA9	TMEM106C	0.35	0.01	lasso	8	-0.01	6.8e-01	12.93	-13.9	1.0e-43	-0.79	0.02	0.79	TRUE
62	GTEx	Testis	SENP1	0.20	0.13	lasso	5	0.10	2.7e-05	-12.70	-12.9	3.7e-38	-0.57	0.04	0.95	TRUE
92	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SENP1	0.09	0.02	enet	10	0.06	1.1e-04	11.68	11.2	2.9e-29	0.62	0.02	0.89	TRUE
56	GTEx	Skin Sun Exposed Lower leg	ZNF641	0.21	0.03	enet	17	0.08	6.5e-07	4.74	-10.4	3.4e-25	-0.60	0.24	0.75	TRUE
93	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TMEM106C	0.09	0.00	blup	76	0.04	1.5e-03	11.68	10.0	2.3e-23	0.62	0.01	0.51	TRUE
55	GTEx	Skin Sun Exposed Lower leg	PFKM	0.22	0.16	enet	34	0.17	5.0e-14	-6.91	-8.0	1.2e-15	-0.33	1.00	0.00	TRUE
80	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ZNF641	0.09	0.01	blup	50	0.03	8.7e-03	-1.43	7.1	1.0e-12	0.72	0.02	0.80	TRUE
43	GTEx	Liver	RP1-228P16.1	0.19	0.08	lasso	7	0.06	7.1e-03	-11.66	12.8	1.4e-37	0.64	0.16	0.33	FALSE
85	The Cancer Genome Atlas	Brain Lower Grade Glioma	H1FNT	0.08	0.08	enet	3	0.07	1.5e-08	12.93	-12.4	3.3e-35	-0.99	0.00	1.00	FALSE
30	GTEx	Breast Mammary Tissue (Female)	ZNF641	0.04	0.01	lasso	1	-0.01	6.0e-01	-12.36	-12.4	4.3e-35	-0.61	0.04	0.16	FALSE
94	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ZNF641	0.05	0.04	blup	50	0.02	1.2e-02	12.93	12.3	1.2e-34	0.95	0.00	0.89	FALSE
41	GTEx	Heart Atrial Appendage	RP1-228P16.1	0.16	0.02	enet	14	0.02	3.2e-02	-12.38	12.2	1.9e-34	0.55	0.14	0.56	FALSE
89	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SENP1	0.04	0.03	blup	87	0.03	4.4e-04	-12.61	12.0	4.8e-33	0.58	0.00	0.99	FALSE
53	GTEx	Skin Not Sun Exposed Suprapubic	ZNF641	0.15	0.11	enet	30	0.10	3.1e-06	-10.32	-11.9	1.5e-32	-0.55	0.64	0.35	FALSE
36	GTEx	Colon Sigmoid	RP1-228P16.1	0.16	0.18	lasso	6	0.13	2.6e-05	-12.61	11.7	9.0e-32	0.54	0.09	0.84	FALSE
29	GTEx	Breast Mammary Tissue (Male)	RP1-228P16.1	0.13	0.00	lasso	6	0.01	1.8e-01	-12.38	11.7	1.8e-31	0.55	0.07	0.27	FALSE
8	GTEx	Adipose Visceral Omentum	RP1-228P16.1	0.18	0.13	lasso	4	0.15	2.3e-08	-8.73	11.5	1.7e-30	0.51	0.17	0.82	FALSE
28	GTEx	Breast Mammary Tissue	RP1-228P16.1	0.22	0.14	lasso	8	0.20	1.3e-10	-12.61	11.4	3.4e-30	0.49	0.09	0.90	FALSE
79	The Cancer Genome Atlas	Breast Invasive Carcinoma	SENP1	0.01	0.00	blup	87	0.01	1.8e-02	11.68	11.4	3.5e-30	0.65	0.04	0.30	FALSE
52	GTEx	Pituitary	RP1-228P16.1	0.20	0.15	lasso	6	0.16	1.1e-04	-8.73	11.3	1.4e-29	0.48	0.30	0.29	FALSE
31	GTEx	Breast Mammary Tissue (Female)	RP1-228P16.1	0.07	-0.01	enet	2	-0.01	5.9e-01	-8.93	11.2	2.7e-29	0.50	0.06	0.16	FALSE
35	GTEx	Cells Transformed fibroblasts	RP1-228P16.1	0.09	0.03	lasso	3	0.04	8.1e-04	-9.38	11.0	2.6e-28	0.44	0.21	0.71	FALSE
38	GTEx	Esophagus Gastroesophageal Junction	RP1-228P16.1	0.23	0.25	enet	17	0.23	6.8e-09	-8.73	11.0	3.0e-28	0.53	0.43	0.56	FALSE
32	GTEx	Cells EBV-transformed lymphocytes	RP1-228P16.1	0.33	0.20	lasso	9	0.29	6.3e-10	-9.38	10.8	2.9e-27	0.46	0.83	0.16	FALSE
63	GTEx	Testis	ASB8	0.17	0.15	lasso	3	0.13	1.8e-06	-9.14	-10.8	3.1e-27	-0.46	0.22	0.68	FALSE
39	GTEx	Esophagus Mucosa	RP1-228P16.1	0.19	0.18	lasso	4	0.21	8.7e-14	-8.73	10.7	6.2e-27	0.50	0.89	0.11	FALSE
15	GTEx	Artery Tibial	RP1-228P16.1	0.16	0.14	lasso	14	0.15	5.9e-12	-8.52	10.7	7.5e-27	0.51	1.00	0.00	FALSE
90	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ASB8	0.07	0.05	lasso	1	0.04	1.0e-03	10.71	10.7	9.3e-27	0.80	0.00	0.90	FALSE
37	GTEx	Colon Transverse	RP1-228P16.1	0.24	0.18	lasso	5	0.18	4.9e-09	-8.73	10.6	2.5e-26	0.47	0.58	0.42	FALSE
47	GTEx	Nerve Tibial	ZNF641	0.14	0.11	lasso	4	0.08	2.3e-06	-10.32	-10.6	2.7e-26	-0.43	1.00	0.00	FALSE
14	GTEx	Artery Tibial	ZNF641	0.19	0.16	lasso	5	0.16	1.6e-12	-10.32	-10.5	7.7e-26	-0.43	1.00	0.00	FALSE
44	GTEx	Lung	ZNF641	0.08	0.10	lasso	2	0.08	8.0e-07	-10.50	-10.5	8.5e-26	-0.42	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	ZNF641	0.10	0.10	lasso	4	0.10	2.8e-08	-10.36	-10.4	2.0e-25	-0.42	1.00	0.00	FALSE
49	GTEx	Nerve Tibial	RP1-228P16.1	0.18	0.21	enet	22	0.21	4.9e-15	-8.93	10.4	3.8e-25	0.47	0.99	0.01	FALSE
5	GTEx	Adipose Subcutaneous	RP1-228P16.1	0.20	0.20	lasso	8	0.22	4.7e-18	-8.93	10.3	4.2e-25	0.44	1.00	0.00	FALSE
46	GTEx	Muscle Skeletal	RP1-228P16.1	0.12	0.10	lasso	9	0.09	7.4e-09	-8.73	10.3	5.5e-25	0.52	0.96	0.04	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SENP1	0.05	0.02	blup	555	0.04	1.7e-05	-10.45	10.2	1.4e-24	0.39	0.78	0.22	FALSE
71	GTEx	Whole Blood	RP1-228P16.1	0.10	0.06	enet	20	0.09	4.7e-09	-8.97	10.0	1.1e-23	0.42	0.73	0.26	FALSE
26	GTEx	Brain Putamen basal ganglia	RP1-228P16.1	0.21	0.24	lasso	6	0.24	2.1e-06	-10.32	10.0	1.5e-23	0.40	0.48	0.14	FALSE
3	CommonMind	Brain Pre-frontal Cortex	ZNF641	0.03	0.01	blup	489	0.02	6.4e-04	-10.50	-9.9	3.1e-23	-0.50	0.28	0.47	FALSE
91	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PFKM	0.10	0.02	lasso	1	0.03	7.5e-03	9.82	9.8	9.2e-23	0.61	0.08	0.75	FALSE
45	GTEx	Lung	RP1-228P16.1	0.18	0.20	enet	21	0.21	7.0e-16	-9.37	9.8	1.6e-22	0.43	1.00	0.00	FALSE
9	GTEx	Adrenal Gland	ZNF641	0.31	0.18	lasso	3	0.21	4.2e-08	-10.61	-9.7	4.7e-22	-0.41	0.76	0.02	FALSE
42	GTEx	Heart Left Ventricle	RP1-228P16.1	0.26	0.14	lasso	16	0.17	1.9e-09	-8.73	9.6	5.0e-22	0.40	0.99	0.01	FALSE
12	GTEx	Artery Aorta	RP1-228P16.1	0.16	0.05	enet	28	0.11	1.7e-06	-10.59	9.6	5.4e-22	0.36	0.22	0.78	FALSE
11	GTEx	Artery Aorta	ZNF641	0.22	0.13	enet	30	0.18	4.9e-10	-10.59	-9.6	7.2e-22	-0.38	0.78	0.22	FALSE
21	GTEx	Brain Cortex	ASB8	0.28	0.19	lasso	7	0.20	3.3e-06	-8.27	-9.6	1.0e-21	-0.42	0.68	0.04	FALSE
87	The Cancer Genome Atlas	Lung Adenocarcinoma	SENP1	0.06	0.03	lasso	3	0.04	4.6e-05	9.82	9.5	3.0e-21	0.59	0.31	0.20	FALSE
34	GTEx	Cells Transformed fibroblasts	ZNF641	0.10	0.05	lasso	4	0.05	7.5e-05	10.73	-9.4	5.4e-21	-0.81	0.25	0.72	FALSE
60	GTEx	Spleen	RP1-228P16.1	0.35	0.23	lasso	7	0.19	1.6e-05	-8.93	9.3	1.5e-20	0.41	0.62	0.24	FALSE
7	GTEx	Adipose Visceral Omentum	ASB8	0.10	0.00	lasso	6	0.00	6.8e-01	-8.97	-9.3	1.8e-20	-0.33	0.30	0.06	FALSE
17	GTEx	Brain Caudate basal ganglia	RP1-228P16.1	0.14	0.12	lasso	4	0.11	5.7e-04	-8.73	9.3	1.8e-20	0.41	0.26	0.09	FALSE
6	GTEx	Adipose Visceral Omentum	ZNF641	0.14	0.09	lasso	4	0.08	3.7e-05	-10.32	-9.3	1.9e-20	-0.38	0.66	0.05	FALSE
72	METSIM	Adipose	ASB8	0.03	0.00	bslmm	526	0.01	3.8e-02	-8.93	-9.2	2.7e-20	-0.46	0.18	0.06	FALSE
77	YFS	Blood	PFKM	0.03	0.00	blup	523	0.01	2.5e-05	4.35	-9.1	1.2e-19	-0.15	0.18	0.04	FALSE
18	GTEx	Brain Cerebellar Hemisphere	RP1-228P16.1	0.30	0.21	lasso	7	0.28	6.5e-08	-8.93	9.0	1.9e-19	0.41	0.94	0.02	FALSE
13	GTEx	Artery Coronary	RP1-228P16.1	0.12	0.06	lasso	2	0.03	2.6e-02	-8.52	8.7	4.0e-18	0.37	0.31	0.40	FALSE
27	GTEx	Breast Mammary Tissue	ASB8	0.17	0.02	enet	12	0.02	1.9e-02	-11.66	-8.7	4.8e-18	-0.25	0.07	0.38	FALSE
48	GTEx	Nerve Tibial	ASB8	0.09	0.08	lasso	4	0.07	1.8e-05	-8.52	-8.5	1.4e-17	-0.39	0.82	0.01	FALSE
23	GTEx	Brain Frontal Cortex BA9	ASB8	0.24	0.16	lasso	6	0.07	7.1e-03	-8.27	-8.5	1.8e-17	-0.41	0.35	0.06	FALSE
86	The Cancer Genome Atlas	Brain Lower Grade Glioma	SENP1	0.04	0.01	enet	8	0.02	1.4e-03	9.82	8.5	2.0e-17	0.55	0.06	0.12	FALSE
75	NTR	Blood	RPAP3	0.02	0.00	bslmm	575	0.00	2.3e-02	-2.05	8.5	2.5e-17	0.16	0.07	0.30	FALSE
40	GTEx	Esophagus Muscularis	RP1-228P16.1	0.20	0.17	enet	14	0.17	1.2e-10	-8.73	8.4	3.1e-17	0.34	0.99	0.01	FALSE
100	The Cancer Genome Atlas	Thyroid Carcinoma	SENP1	0.04	0.01	lasso	3	0.00	1.3e-01	8.42	8.4	3.8e-17	0.53	0.02	0.21	FALSE
70	GTEx	Uterus	RP1-228P16.1	0.32	0.09	lasso	15	0.01	2.1e-01	-9.37	8.3	7.9e-17	0.39	0.11	0.22	FALSE
51	GTEx	Pancreas	RP1-228P16.1	0.12	0.05	enet	10	0.05	5.0e-03	-4.31	8.3	9.0e-17	0.31	0.37	0.15	FALSE
61	GTEx	Stomach	RP1-228P16.1	0.12	0.03	lasso	7	0.05	1.9e-03	-8.73	8.3	1.2e-16	0.34	0.77	0.06	FALSE
10	GTEx	Adrenal Gland	RP1-228P16.1	0.19	0.20	lasso	5	0.15	4.4e-06	-8.47	8.3	1.5e-16	0.37	0.91	0.01	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	RP1-228P16.1	0.17	0.10	enet	23	0.16	4.1e-09	-10.47	8.1	6.3e-16	0.20	0.95	0.03	FALSE
68	GTEx	Thyroid	RP1-228P16.1	0.30	0.30	enet	41	0.33	1.4e-25	-8.50	8.1	7.3e-16	0.33	1.00	0.00	FALSE
98	The Cancer Genome Atlas	Thyroid Carcinoma	ASB8	0.04	0.03	lasso	3	0.03	2.3e-04	-8.27	-7.9	2.7e-15	-0.39	0.52	0.12	FALSE
25	GTEx	Brain Nucleus accumbens basal ganglia	ASB8	0.20	0.04	lasso	4	0.02	7.7e-02	-9.37	-7.8	8.4e-15	-0.34	0.13	0.19	FALSE
19	GTEx	Brain Cerebellum	RP1-228P16.1	0.16	0.05	enet	16	0.10	6.0e-04	-4.29	7.7	1.1e-14	0.25	0.33	0.09	FALSE
64	GTEx	Testis	RP1-228P16.1	0.38	0.28	lasso	6	0.31	4.0e-14	-8.93	7.7	1.5e-14	0.37	1.00	0.00	FALSE
95	The Cancer Genome Atlas	Prostate Adenocarcinoma	SENP1	0.06	0.00	blup	87	0.01	5.7e-02	0.31	7.4	1.3e-13	0.62	0.05	0.08	FALSE
83	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF641	0.09	0.01	blup	50	0.06	7.1e-07	6.82	-7.3	3.0e-13	-0.09	0.15	0.03	FALSE
20	GTEx	Brain Cortex	TMEM106C	0.21	0.04	enet	20	0.10	1.0e-03	-8.93	-7.2	4.7e-13	-0.16	0.16	0.11	FALSE
102	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF641	0.11	0.12	enet	10	0.12	5.2e-12	-10.61	-7.1	1.0e-12	-0.14	1.00	0.00	FALSE
65	GTEx	Thyroid	ZNF641	0.16	0.06	enet	26	0.13	2.0e-10	-1.01	-7.0	3.5e-12	-0.19	1.00	0.00	FALSE
16	GTEx	Brain Caudate basal ganglia	ASB8	0.18	0.02	lasso	4	0.04	2.1e-02	-8.27	-6.9	3.7e-12	-0.35	0.12	0.11	FALSE
96	The Cancer Genome Atlas	Stomach Adenocarcinoma	ASB8	0.09	0.01	blup	69	0.04	1.1e-03	9.91	6.9	5.0e-12	0.38	0.02	0.75	FALSE
50	GTEx	Ovary	C12orf68	0.38	0.08	enet	29	0.05	1.9e-02	-6.59	-6.9	5.9e-12	-0.30	0.07	0.07	FALSE
67	GTEx	Thyroid	ASB8	0.09	0.00	enet	34	0.01	2.8e-02	-8.54	-6.8	9.2e-12	-0.16	0.65	0.04	FALSE
57	GTEx	Skin Sun Exposed Lower leg	RP1-228P16.1	0.29	0.24	enet	28	0.26	2.0e-21	-8.50	6.8	1.2e-11	0.26	1.00	0.00	FALSE
58	GTEx	Spleen	ZNF641	0.42	0.21	lasso	11	0.28	5.4e-08	-0.35	-6.8	1.3e-11	-0.20	0.70	0.02	FALSE
78	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SENP1	0.10	0.05	blup	87	0.04	2.2e-04	8.42	6.8	1.3e-11	0.48	0.39	0.09	FALSE
97	The Cancer Genome Atlas	Stomach Adenocarcinoma	SENP1	0.09	0.03	lasso	4	0.03	4.8e-03	8.64	6.6	3.3e-11	0.47	0.40	0.06	FALSE
101	The Cancer Genome Atlas	Thyroid Carcinoma	VDR	0.06	0.03	enet	18	0.03	3.1e-04	5.09	6.5	7.5e-11	0.26	0.16	0.06	FALSE
88	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM106C	0.04	0.01	blup	76	0.02	1.3e-03	8.42	6.4	1.2e-10	0.41	0.02	0.47	FALSE
84	The Cancer Genome Atlas	Brain Lower Grade Glioma	ASB8	0.08	0.01	blup	69	0.04	3.9e-05	-8.27	-6.4	1.9e-10	-0.20	0.41	0.26	FALSE
81	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SENP1	0.07	0.01	blup	87	0.02	1.9e-03	8.42	6.3	3.7e-10	0.55	0.11	0.04	FALSE
59	GTEx	Spleen	C12orf68	0.24	0.01	lasso	4	0.03	6.8e-02	-6.88	-6.2	4.4e-10	-0.32	0.12	0.16	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TMEM106C	0.13	0.06	enet	21	0.11	3.2e-13	-8.33	-6.2	7.7e-10	-0.20	1.00	0.00	FALSE
82	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ASB8	0.04	0.03	blup	69	0.03	4.1e-04	-10.47	-6.1	1.0e-09	-0.25	0.05	0.83	FALSE
74	METSIM	Adipose	PFKM	0.05	0.01	bslmm	525	0.02	7.3e-04	-6.40	6.0	1.6e-09	0.34	0.48	0.02	FALSE
24	GTEx	Brain Hippocampus	ZNF641	0.19	0.07	enet	10	0.04	3.3e-02	6.41	6.0	1.8e-09	0.41	0.07	0.28	FALSE
73	METSIM	Adipose	DKFZP779L1853	0.03	0.02	lasso	5	0.03	9.8e-06	-0.93	5.9	3.0e-09	0.45	0.62	0.23	FALSE
66	GTEx	Thyroid	ADCY6	0.11	0.01	enet	29	0.03	3.1e-03	-2.14	-5.9	4.6e-09	-0.01	0.07	0.04	FALSE
69	GTEx	Thyroid	RP11-579D7.2	0.14	0.02	enet	31	0.02	7.3e-03	1.83	-5.8	8.1e-09	-0.13	0.14	0.04	FALSE
99	The Cancer Genome Atlas	Thyroid Carcinoma	OR10AD1	0.06	0.03	lasso	3	0.05	7.6e-06	-0.62	-5.5	4.0e-08	-0.08	0.12	0.63	FALSE
33	GTEx	Cells Transformed fibroblasts	VDR	0.22	0.17	lasso	5	0.16	3.3e-12	-5.26	-5.3	1.2e-07	-0.28	1.00	0.00	FALSE
76	NTR	Blood	VDR	0.05	0.02	enet	24	0.02	1.5e-08	5.39	5.2	2.0e-07	0.26	0.99	0.00	FALSE