Hub : Genes

VDR

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.2160 0.0490 5.5e-09 0.166 NA 0.144 NA 0.162 1.9e-12 NA 5.9e-11 NA 3.3e-12
2 NTR Blood 0.0543 0.0155 3.4e-07 0.021 0.019 0.025 0.023 0.022 2.2e-07 4.7e-07 1.6e-08 4.1e-08 7.1e-08
3 TCGA Ovarian Serous Cystadenocarcinoma 0.1200 0.0490 2.2e-03 0.063 0.016 0.014 NA 0.045 4.5e-05 2.6e-02 3.5e-02 NA 5.4e-04
4 TCGA Thyroid Carcinoma 0.0640 0.0310 2.0e-03 0.034 0.019 0.033 NA 0.023 2.8e-04 5.2e-03 3.1e-04 NA 2.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.7 1.1 1.6 1.1 -1.3 -1.1 -0.7
Bipolar Disorder or Schizophrenia 0.6 1.5 2.9 -1.2 -1.2 -1.7 -0.4
Depressed Affect (Nagel 2018) 0.9 1.9 4.0 2.0 -0.2 -0.4 -1.9
Depression (Nagel 2018) 0.5 0.7 1.7 1.3 0.3 -0.3 -0.9
Intelligence (Savage-Jansen 2018) 0.6 1.7 4.0 -0.8 1.3 -0.7 2.0
Neuroticism (Nagel 2018) 0.5 1.1 3.6 1.9 0.6 0.5 -0.4
Schizophrenia (2018) 0.8 1.6 5.8 -2.4 -0.5 -0.7 0.2
Schizophrenia vs Biploar Disorder 0.4 0.5 1.3 -1.1 0.5 0.7 0.1
Worry (Nagel 2018) 1.1 2.2 3.5 1.5 1.8 0.0 1.9
Alzheimer’s Disease (in mother) 0.5 0.6 1.5 0.6 1.2 0.6 0.2
Alzheimer’s Disease (in father) 0.7 0.8 1.7 -0.8 -0.4 1.3 0.8
Alzheimer’s Disease (including proxy) 0.3 0.5 1.9 0.1 0.1 1.4 0.0
Crohns Disease (2017) 0.3 0.6 2.3 0.2 0.5 -0.1 -1.5
Irritable Bowel Disease (IBD) 0.6 1.4 2.9 -1.3 -0.4 -0.9 -1.7
Ulcerative Colitis (UC) 1.0 1.8 2.9 -1.7 -1.0 -1.4 -1.1
Major Depression (MDD) 0.6 0.7 2.5 0.4 0.5 -1.6 0.0
Reaction Time 0.7 1.2 3.9 -0.4 0.9 -2.0 0.2
Verbal and Numeric Reasoning (VNR) 0.2 0.4 0.8 -0.9 0.4 -0.0 0.9
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.8 1.1 2.9 1.7 0.3 0.3 -1.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.2 1.7 4.1 -1.4 -2.0 -0.1 -0.7
Bipolar Disorder (2011) 0.7 0.7 1.4 -1.2 -1.0 -0.7 -0.1
Body Mass Index (BMI) (2010) 0.4 0.6 1.7 -0.7 0.4 0.3 1.3
Coronary Artery Disease (CAD) 0.7 0.9 1.5 -1.0 -0.8 0.4 -1.2
Crohns Disease (2012) 0.2 0.3 0.8 0.1 0.3 -0.4 -0.9
Mean Putamen Volume 0.4 0.4 1.0 -0.1 0.7 0.5 -1.0
Fasting Glucose 0.5 0.6 1.7 0.4 0.4 -0.5 -1.3
HbA1C 0.4 0.4 1.1 0.4 -1.1 -0.1 0.6
HDL Cholesterol 0.4 0.6 2.3 -1.5 -0.2 -0.2 -0.1
LDL Cholesterol 0.8 1.3 3.3 0.5 -1.8 0.3 -1.3
Lupus 1.3 2.0 4.0 -2.0 0.7 1.5 1.2
Neuroticism (2016) 0.2 0.3 0.6 0.6 0.8 -0.5 0.2
Primary Biliary Cirrhosis 0.5 0.7 1.6 0.9 -0.6 -1.3 -0.5
Rheumatoid Arthritis 1.8 2.5 7.4 -0.8 -0.7 2.7 1.1
Schizophrenia (2014) 0.8 1.7 5.2 -2.3 -0.1 -1.3 0.1
Triglycerides 0.2 0.2 0.7 0.3 0.4 0.8 -0.2
Type 2 Diabetes (T2D) (2012) 1.2 1.3 3.6 1.3 -0.2 -1.9 0.2
Ulcerative Colitis 1.3 1.9 3.1 -1.7 -1.1 -1.5 -1.1
Blood Eosinophil Count 0.2 1.3 2.2 1.5 -1.1 -0.3 1.4
Blood Platelet Count 0.6 7.3 19.3 0.5 -2.1 2.2 -4.4
Blood Red Count 2.5 24.4 42.4 -5.3 5.2 -0.4 6.5
Blood White Count 0.3 2.2 3.4 1.8 1.0 1.3 1.8
Heel T-Score 0.9 7.1 21.8 -4.7 -0.7 1.2 2.1
BMI 0.1 0.4 0.4 0.6 0.6 0.6 0.5
Height 0.1 2.4 4.2 1.9 2.0 -0.1 -1.4
Waist Hip Ratio (WHR) 0.2 0.8 2.6 1.6 -0.7 0.2 -0.2
Systolic Blood Pressure 2.2 10.9 31.8 3.3 0.1 0.9 -5.6
Smoking Status 2.9 6.9 14.2 -1.4 -3.8 -3.2 -1.1
Allergy or Eczema 0.2 0.6 1.4 0.6 0.2 -0.8 -1.2
Cardiovascular Disease 1.6 5.4 10.8 3.2 0.6 -0.6 -3.3
Hypothyroidism (self reported) 0.2 0.5 1.1 0.4 0.3 1.0 0.7
Respiratory disease 0.2 0.4 1.0 0.6 0.6 1.0 -0.0
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.3 1.1 -0.9 -0.1 -0.7
Lung FEV1/FVC ratio 0.5 2.6 6.9 -2.6 -1.3 -1.3 0.6
Lung FVC 1.3 6.4 12.7 -3.6 0.2 -0.5 3.5
Neuroticism 0.5 1.1 3.6 1.9 0.2 -0.2 -0.9
Chronotype (morning person) 1.0 2.3 6.2 -0.6 2.5 0.6 1.5
Hair Pigment 0.0 0.7 1.4 1.2 0.0 1.2 0.3
Tanning 0.1 0.9 1.8 -0.9 -0.8 -0.4 -1.3
Hand grip strength (left) 1.9 5.0 14.9 -3.9 0.2 0.8 2.0
Number of treatments/medications taken 1.0 1.7 3.0 1.3 1.7 -1.3 -0.9
Average weekly spirits intake 0.8 1.0 2.4 1.5 -0.8 1.0 -0.3
Sensitivity / hurt feelings 0.3 0.4 1.3 1.1 -0.3 -0.2 -0.6
Frequency of depressed mood in last 2 weeks 0.7 0.9 1.5 1.2 -0.5 -1.1 -0.9
Hearing difficulty/problems: Yes 0.0 0.1 0.2 0.3 -0.1 0.5 -0.1
Relative age of first facial hair 1.1 2.3 5.0 -0.5 1.8 1.0 2.2
Other serious medical condition/disability diagnosed by doctor 0.7 1.0 3.0 -1.7 -0.6 -0.6 0.5
Ever used hormone-replacement therapy (HRT) 2.8 3.6 7.3 -1.2 2.3 0.5 2.7
Ever had hysterectomy (womb removed) 0.3 0.4 0.6 0.7 0.4 -0.7 -0.5
Systolic blood pressure, automated reading 1.3 3.7 5.2 1.9 1.7 1.8 -2.3
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 1.7 -1.3 -0.9 -1.3 -0.1
Angina 0.3 0.4 1.1 1.0 0.4 0.0 -0.5
Medication for hormone replacement therapy 0.4 0.4 1.2 1.1 -0.2 0.7 -0.2
Vitamin and mineral supplements 0.9 1.3 2.3 0.9 -1.4 1.5 -0.3
Supplements: Zinc 1.0 1.1 2.3 0.1 -0.2 -1.5 -1.4
Medication: Co-codamol 1.3 1.5 4.8 -0.6 2.2 0.5 -0.7
Medication: Metformin 1.2 1.7 3.7 1.0 -1.9 -1.0 -1.1
Diabetes (father) 0.3 0.4 0.9 -0.8 0.3 -1.0 -0.2
Diabetes (mother) 1.0 1.3 3.3 0.5 1.8 0.9 1.0
Severe depression (siblings) 1.2 1.3 2.5 0.8 1.6 -0.3 1.4
Pack years adult smoking proportion 0.6 0.9 1.6 1.2 -0.9 -0.1 -1.2
Impedance of leg (right) 1.0 4.7 13.3 3.6 -0.0 -2.3 -0.3
Leg fat-free mass (left) 0.3 1.7 3.1 -1.2 -0.0 1.8 -1.5
Trunk fat percentage 0.6 2.6 6.3 2.5 1.9 0.6 0.1
Hand grip strength (right) 1.1 2.9 10.4 -3.2 0.3 0.3 1.0
Townsend deprivation index at recruitment 0.9 1.3 2.3 0.7 -1.5 -1.3 -0.8
Current tobacco smoking 0.7 1.1 1.8 -0.6 -1.3 -0.8 -1.3
Average weekly fortified wine intake 0.3 0.4 1.0 -0.0 -0.6 -1.0 -0.5
Maternal smoking around birth 0.5 0.8 1.3 1.0 1.1 -0.9 0.0
Fed-up feelings 1.0 1.8 3.5 1.5 -0.3 -1.0 -1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 2.5 1.5 -1.4 -0.3 -1.6
Relative age voice broke 0.7 1.0 2.2 -0.5 1.5 0.4 1.3
Taking other prescription medications 0.4 0.7 1.4 1.2 0.5 -1.0 -0.3
Age when periods started (menarche) 1.0 2.3 5.3 2.3 1.7 0.7 0.8
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 2.9 -0.0 -1.2 -1.7 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.8 -1.7 0.0 0.9 0.1
Tinnitus: Yes, but not now, but have in the past 1.8 1.9 4.2 -2.1 1.1 -0.3 1.4
Qualifications: CSEs or equivalent 2.1 2.8 5.9 1.4 -2.4 -0.4 -1.8
Serious illness, injury or assault to yourself 1.2 1.4 2.8 1.7 0.5 -1.4 -0.8
High blood pressure 2.3 6.5 11.6 3.4 2.0 0.3 -3.2
Hayfever, allergic rhinitis or eczema 0.7 1.6 3.8 1.0 -0.5 -1.1 -1.9
Multivitamins +/- minerals 1.3 1.6 5.0 -0.5 0.8 -2.2 0.7
Stomach or abdominal pain in last month 1.0 1.3 2.9 -0.7 -1.1 -0.6 -1.7
Supplements: Glucosamine 1.0 1.3 4.5 -2.1 -0.3 0.6 -0.3
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.7 0.3 0.8 -0.1 -0.2
Medication: Atenolol 1.0 1.2 4.4 0.0 2.1 0.7 0.4
Medication: Levothyroxine sodium 0.5 0.8 1.3 1.1 1.1 0.6 -0.8
Sitting height 0.3 2.3 5.6 0.5 1.7 0.4 -2.4
Chronic bronchitis/emphysema (father) 0.3 0.3 1.2 -0.1 0.3 1.1 -0.2
High blood pressure (mother) 5.3 7.5 13.4 3.0 -0.7 -2.6 -3.7
Body mass index (BMI) 0.2 0.7 2.6 -0.1 0.2 1.6 -0.0
Impedance of leg (left) 0.7 3.5 9.9 3.1 -0.1 -2.0 0.4
Leg predicted mass (left) 0.3 1.7 3.0 -1.1 -0.1 1.7 -1.6
Trunk fat mass 0.4 1.8 3.6 1.9 1.5 1.0 -0.4
Waist circumference 0.3 1.2 3.2 1.2 0.0 1.8 -0.2
Number of incorrect matches in round 1.4 2.3 7.6 -0.7 0.7 0.9 2.8
Past tobacco smoking 0.7 1.2 2.2 -0.3 1.4 1.5 -0.9
Alcohol usually taken with meals 0.6 1.0 1.9 -0.7 -1.2 0.0 -1.4
Nervous feelings 0.9 1.7 3.5 1.6 0.9 -0.1 1.9
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.0 3.5 1.8 -0.5 -1.9 -0.9
Hearing difficulty/problems with background noise 1.1 1.7 3.3 -0.5 1.7 0.4 1.8
Hair/balding pattern: Pattern 2 2.3 2.9 4.8 -2.2 -1.0 -1.8 -1.7
Had menopause 1.6 2.0 2.9 1.3 1.7 1.3 1.4
Had other major operations 0.1 0.1 0.1 -0.1 0.1 -0.4 -0.3
Forced vital capacity (FVC) 0.7 2.9 8.4 -2.9 -1.4 -0.5 0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 2.0 -1.3 0.7 1.4 0.4
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 5.4 0.7 0.3 -2.3 0.2
Qualifications: None of the above 0.6 1.2 3.5 0.9 1.9 -0.0 0.8
Financial difficulties in last 2 years 0.9 1.3 1.8 1.0 -1.3 -0.7 -1.4
Mouth/teeth dental problems 0.7 1.0 1.5 -1.1 -1.1 -1.2 -0.5
Heart attack 0.4 0.5 1.3 -0.1 0.3 1.1 0.7
Allergy 0.2 0.5 1.1 -0.6 0.2 0.6 1.1
Pain all over the body in last month 0.7 0.7 1.4 -1.2 -0.7 -0.8 -0.5
Diabetes (self-reported) 0.8 1.2 2.1 1.1 -1.5 -0.9 -0.8
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.0 -0.4 0.1 -1.0 -0.7
Medication: Ramipril 2.1 2.8 4.6 2.1 -0.9 -1.2 -2.0
Medication: Simvastatin 0.9 1.3 4.6 2.1 -0.0 -0.2 -0.9
Fluid intelligence score 0.6 1.2 3.6 -0.4 0.9 0.2 1.9
Illnesses of siblings 0.3 0.4 1.3 -0.1 -1.2 -0.2 -0.0
Neuroticism score 0.4 0.8 2.6 1.6 0.1 -0.6 -0.5
Weight 0.2 1.0 3.1 0.2 0.0 1.8 -1.0
Impedance of arm (right) 1.5 6.9 14.0 3.7 2.6 -2.4 1.2
Arm fat percentage (right) 0.3 1.3 2.9 1.7 1.4 0.4 0.4
Trunk fat-free mass 0.5 2.6 5.0 -1.8 -0.6 2.2 -1.4
Hip circumference 0.3 1.1 2.3 0.8 0.1 1.5 -1.2
Time employed in main current job 0.5 0.6 1.8 0.4 1.3 -0.5 -0.2
Alcohol intake versus 10 years previously 1.2 1.8 4.1 2.0 1.3 -1.1 -0.6
Father’s age at death 0.0 0.0 0.1 -0.2 -0.3 0.1 0.1
Worrier / anxious feelings 0.9 1.7 3.5 1.6 1.9 -0.5 0.6
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 3.8 1.3 -0.2 -0.9 -2.0
Falls in the last year 1.2 1.6 4.7 2.2 -0.9 0.6 -0.8
Hair/balding pattern: Pattern 3 1.4 2.0 3.5 1.9 1.5 -1.5 0.5
Number of live births 0.4 0.6 0.8 0.6 0.9 0.7 0.9
Forced expiratory volume in 1-second (FEV1) 1.2 4.1 12.6 -3.6 -1.5 -0.3 1.2
Pulse rate 0.5 0.8 1.5 1.2 0.3 -0.9 1.0
Happiness 0.5 0.6 1.4 1.0 0.3 -1.2 0.1
Noisy workplace 0.7 0.9 2.1 -1.4 -0.5 -0.6 -1.0
Qualifications: A levels/AS levels or equivalent 0.5 1.0 3.1 -0.5 -1.8 0.2 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.8 1.0 2.3 0.0 -1.5 -0.8 -0.9
Mouth/teeth dental problems: Dentures 0.6 1.0 1.9 0.4 1.3 -0.4 1.4
Asthma 0.1 0.2 0.3 -0.2 -0.5 0.4 -0.5
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 2.7 1.6 1.6 0.2 0.6
Medication: Cholesterol lowering 2.0 3.0 6.9 1.6 -1.6 -0.4 -2.6
Depression (self-reported) 1.1 1.4 2.9 1.2 1.1 -0.2 1.7
Medication: Lansoprazole 0.2 0.2 0.3 0.4 0.5 0.1 0.5
Prospective memory result 0.2 0.2 0.7 0.1 0.4 0.9 -0.2
Lung cancer (father) 2.2 2.6 6.8 1.0 2.6 0.4 1.6
Illnesses of mother 2.4 2.9 6.2 -2.5 -1.2 0.7 1.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.1 10.1 -3.2 -1.3 -0.6 0.6
Pulse wave Arterial Stiffness index 1.4 1.6 5.3 -0.7 0.3 2.3 -0.8
Impedance of arm (left) 1.2 5.7 10.1 3.2 2.1 -2.8 0.8
Arm fat mass (right) 0.2 0.7 1.2 1.0 1.1 0.8 -0.1
Trunk predicted mass 0.5 2.6 4.9 -1.8 -0.5 2.2 -1.4
Standing height 0.1 1.0 3.6 0.3 0.1 0.3 -1.9
Length of working week for main job 0.4 0.4 1.3 0.2 1.1 0.6 -0.3
Exposure to tobacco smoke at home 1.9 2.1 4.1 1.8 -2.0 -0.4 -1.0
Breastfed as a baby 1.6 2.0 6.2 -2.5 -0.9 0.9 0.0
Tense / ‘highly strung’ 0.8 1.4 3.3 -0.1 1.8 -0.2 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.4 0.6 -0.3 0.0 0.6
Hair/balding pattern: Pattern 4 0.3 0.8 1.4 -1.2 -0.5 0.4 -1.2
Birth weight of first child 0.2 0.4 0.9 0.8 -0.2 1.0 -0.2
Peak expiratory flow (PEF) 2.6 6.0 17.5 -4.2 -2.6 0.0 0.2
Pulse wave reflection index 3.0 3.7 6.5 -1.6 -1.0 2.5 -2.2
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.1 0.2 -1.1 -0.9 -0.6
Loud music exposure frequency 0.4 0.4 1.0 1.0 -0.7 -0.1 -0.5
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 3.2 0.8 -1.6 -0.8 -1.8
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 2.6 1.6 0.2 1.1 -1.0
Blood clot in the leg (DVT) 0.5 0.6 0.8 0.2 -0.8 0.9 -0.9
Medication: Paracetamol 1.1 1.9 3.1 1.6 1.8 -1.3 0.1
Headache pain in last month 1.8 3.1 6.2 2.3 -0.8 -0.4 -2.5
Medication for cholesterol, blood pressure or diabetes 2.4 3.9 10.2 -3.2 -0.3 -0.6 2.3
Glaucoma (self-reported) 0.7 0.9 2.7 1.6 -0.3 0.4 -0.7
Gout (self-reported) 1.5 2.1 6.6 -0.2 2.6 -0.3 1.2
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.7 0.5 0.8 0.8 0.4
Medication: Amlodipine 3.5 4.9 9.9 2.8 -0.3 1.3 -3.1
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.3 -0.4 0.5 0.0 0.3
Birth weight 0.3 0.7 1.8 -0.7 0.6 0.3 1.3
Chronic bronchitis/emphysema (mother) 1.0 1.1 1.7 1.3 0.8 1.1 0.9
High blood pressure (siblings) 0.5 0.7 2.0 0.8 1.4 0.4 -0.1
Forced vital capacity (FVC), Best measure 0.5 2.0 5.8 -2.4 -1.1 -0.7 0.6
Body fat percentage 0.4 1.7 4.7 2.2 1.4 0.5 0.1
Leg fat percentage (right) 0.3 1.2 3.9 2.0 0.7 0.5 -0.0
Arm fat-free mass (right) 0.6 2.9 4.6 -1.9 -1.0 2.1 -1.6
Exposure to tobacco smoke outside home 0.3 0.4 1.1 1.0 -0.3 -0.4 0.3
Comparative body size at age 10 0.6 1.7 5.3 -0.8 -0.2 0.7 2.3
Number of full brothers 0.6 0.8 1.9 0.7 -0.6 -1.4 0.7
Worry too long after embarrassment 0.3 0.6 1.1 1.1 0.9 0.2 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.6 0.2 0.7 -1.2 0.3
Wheeze or whistling in the chest in last year 1.1 2.0 4.3 2.1 -0.4 -1.5 -1.1
Number of children fathered 1.5 1.6 2.9 -1.2 -1.7 1.4 0.6
Reason for reducing amount of alcohol drunk: Health precaution 2.2 2.6 7.2 0.1 1.5 1.1 2.7
Age at first live birth 0.5 0.8 2.1 -0.4 -1.0 1.5 -0.1
Pulse wave peak to peak time 1.5 1.7 5.6 0.9 -0.4 -2.4 0.6
Health satisfaction 1.4 1.9 4.7 2.2 -0.4 0.5 -1.5
Shortness of breath walking on level ground 2.4 2.9 5.5 2.2 -1.2 0.0 -2.3
Qualifications: College or University degree 0.1 0.4 0.8 -0.9 -0.3 0.6 -0.7
Eye problems/disorders: None of the above 0.2 0.2 0.4 -0.7 0.5 -0.3 -0.3
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.6 -0.1 -0.2 -0.6 -0.8
Emphysema/chronic bronchitis 0.9 1.0 1.6 1.3 0.8 -0.8 1.0
Medication for pain relief, constipation, heartburn 1.4 2.3 4.0 -2.0 -1.9 1.3 0.2
Neck or shoulder pain in last month 0.6 0.8 1.4 -0.2 -1.0 -1.0 -1.2
Medication: Blood pressure 2.3 4.1 10.1 3.2 1.2 0.2 -2.2
Angina (self-reported) 0.3 0.4 1.2 1.1 0.2 0.3 -0.5
Migraine (self-reported) 1.4 1.7 6.0 2.5 0.3 0.7 -0.6
Medication: Ibuprofen 1.3 1.5 3.4 1.3 1.8 0.4 0.9
Medication: Allopurinol 1.0 1.3 4.8 0.2 2.2 -0.7 -0.0
Medication: Omeprazole 0.5 0.6 1.2 -0.0 0.9 -1.1 0.6
Medication: Seretide 50 evohaler 0.5 0.6 1.7 -0.2 -0.5 -0.7 1.3
Mean time to correctly identify matches 1.7 3.3 5.6 -0.8 2.4 -2.4 1.2
Heart disease (mother) 0.4 0.5 1.1 0.0 0.5 -0.8 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.5 1.5 0.7 -1.2 0.5 -0.2
Whole body fat mass 0.3 1.1 1.7 1.3 1.1 1.1 -0.4
Leg fat mass (right) 0.2 0.9 1.9 1.4 0.5 0.9 -0.7
Arm predicted mass (right) 0.5 2.8 5.1 -1.5 -1.0 2.2 -1.7
Pulse rate, automated reading 0.8 2.5 3.7 1.9 1.9 -1.5 0.6
Alcohol intake frequency. 0.6 1.5 2.4 1.5 0.1 -1.0 -1.6
Comparative height size at age 10 0.1 0.4 1.2 -1.1 -0.0 0.4 0.3
Number of full sisters 1.5 1.8 4.0 0.5 2.0 0.4 1.6
Suffer from ‘nerves’ 0.6 1.0 3.5 1.9 -0.3 0.4 -0.2
Overall health rating 3.4 7.3 13.4 3.7 -1.7 -0.8 -3.5
Chest pain or discomfort 1.8 2.6 6.1 2.5 -0.2 -1.2 -1.7
Had major operations 0.5 0.6 1.4 0.8 0.3 1.2 0.5
Age at last live birth 0.3 0.5 0.7 0.8 -0.9 0.8 0.2
Family relationship satisfaction 0.3 0.3 0.8 -0.7 -0.9 0.1 0.1
Leg pain on walking 0.9 1.1 2.3 1.5 0.1 0.1 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.0 -1.0 -1.0 -0.1 0.5
Commuting to job workplace: Car/motor vehicle 2.0 2.3 5.5 -0.7 1.6 1.0 2.3
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 2.3 -0.5 1.0 1.5 1.2
Medication: Aspirin 0.5 0.6 1.3 1.1 -0.1 -0.1 -1.1
Supplements: Vitamin C 1.0 1.2 3.7 -0.4 0.7 -1.9 -0.6
Knee pain experienced in last month 3.0 4.7 7.5 2.7 -1.6 -1.2 -2.7
Hypertension (Self-reported) 2.1 5.9 10.8 3.3 2.0 0.5 -2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.3 -0.5 0.3 0.4 0.2
Illnesses of father: Heart disease 2.3 3.2 6.1 -2.5 -1.2 -1.5 -1.8
Illnesses of siblings: Diabetes 0.1 0.1 0.2 -0.1 -0.3 -0.5 0.2
Smoking status: Previous 1.1 1.7 4.8 -0.3 -0.9 -2.2 1.1
Forced expiratory volume in 1-second (FEV1), predicted 1.4 2.9 7.2 0.7 -2.7 0.3 -2.0
Whole body fat-free mass 0.4 2.4 4.8 -1.7 -0.4 2.2 -1.3
Leg fat-free mass (right) 0.4 1.9 4.0 -1.7 -0.1 2.0 -1.0
Arm fat percentage (left) 0.3 1.0 2.1 1.5 1.3 0.2 0.3
Average weekly red wine intake 1.4 2.1 7.5 -2.7 -0.7 -0.5 0.2
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.7 0.2 -0.4 0.9 0.4
Mood swings 0.5 0.8 1.9 1.4 -0.0 0.4 -1.1
Loneliness, isolation 3.1 4.3 10.1 1.1 -1.6 -1.8 -3.2
Long-standing illness, disability or infirmity 0.5 0.7 2.2 0.5 -0.5 -0.3 -1.5
Ever had bowel cancer screening 0.9 1.1 3.0 1.1 1.7 -0.5 0.1
Diabetes diagnosed by doctor 0.6 1.0 2.1 1.0 -1.4 -0.6 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 1.5 -1.1 -1.2 0.0 -0.9
Friendships satisfaction 0.6 0.8 1.5 1.2 0.3 -1.2 0.0
Qualifications: nursing, teaching 0.3 0.5 1.4 -1.2 0.2 0.7 -0.4
Commuting to job workplace: Walk 1.1 1.1 2.0 -0.6 -1.4 -1.4 -0.7
Eye problems/disorders: Cataract 0.1 0.1 0.4 0.3 -0.6 -0.1 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.5 0.4 0.2 0.4 0.7
Medication for cholesterol 1.0 1.6 3.2 -1.8 -0.1 0.4 1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 3.2 1.8 -0.1 -1.1 -0.5
Back pain experienced in last month 1.5 2.2 4.6 -0.5 -2.0 0.1 -2.1
Mineral and other dietary supplements 0.8 1.0 3.4 1.8 -0.7 0.5 -0.1
Breast cancer (self-reported) 0.4 0.5 1.4 -0.0 -0.4 -0.6 -1.2
Asthma (self-reported) 0.1 0.1 0.2 -0.2 -0.3 0.5 -0.5
Osteoporosis (self-reported) 2.2 2.8 8.8 -0.4 -3.0 -1.2 -0.8
Osteoarthritis (self-reported) 0.3 0.4 1.1 0.7 0.3 0.1 -1.0
Medication: Aspirin 0.4 0.5 1.0 1.0 -0.6 -0.1 -0.7
Medication: Gliclazide 0.9 1.0 3.1 1.8 -0.4 0.0 -0.8
Illnesses of father: None of the above (group 1) 1.0 1.2 4.0 0.9 0.2 -0.2 2.0
Smoking status: Current 0.7 1.1 2.2 -0.8 -1.5 -0.4 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.7 7.3 -2.7 0.2 -1.3 1.3
Whole body water mass 0.4 2.5 4.7 -1.6 -0.4 2.2 -1.5
Leg predicted mass (right) 0.4 1.9 3.8 -1.6 -0.1 1.9 -1.1
Arm fat mass (left) 0.2 0.7 1.1 0.9 1.0 0.8 -0.2
Number of self-reported non-cancer illnesses 1.2 2.0 5.5 2.3 1.3 -0.3 -1.0
Average weekly champagne plus white wine intake 0.8 1.1 3.7 0.5 -0.5 1.9 0.1
Miserableness 0.6 1.0 3.5 1.9 -0.5 0.1 -0.6
Guilty feelings 1.0 1.4 4.0 0.8 -0.7 -2.0 -0.7
Wears glasses or contact lenses 2.7 3.1 10.5 0.8 3.2 0.0 1.1
Ever taken oral contraceptive pill 0.8 0.9 2.2 0.6 1.5 -1.0 -0.3
Hearing aid user 2.5 2.8 7.3 1.6 0.8 2.7 0.7
Mother’s age at death 1.6 2.1 3.2 1.1 1.5 1.3 1.8
Financial situation satisfaction 0.4 0.6 1.0 0.7 0.2 -0.8 -1.0
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.3 -0.5 -0.6 0.2 1.1
Commuting to job workplace: Public transport 3.2 3.8 8.7 3.0 -1.6 -1.4 -1.4
Eye problems/disorders: Glaucoma 0.8 0.9 2.1 1.5 -0.2 1.1 -0.7
Medication: Blood pressure 1.7 3.2 8.0 2.1 0.5 -0.2 -2.8
Pain type(s) experienced in last month: Hip pain 0.4 0.6 1.3 -0.5 -0.6 0.6 -1.1
Supplements: Fish oil (including cod liver oil) 2.3 3.0 6.3 -2.5 1.7 0.4 1.6
High cholesterol (Self-reported) 0.5 0.8 2.1 1.4 -0.5 -0.7 -0.8
Medication: Bendroflumethiazide 1.6 2.4 7.5 0.5 -0.8 -1.1 -2.7
Medication: Paracetamol 1.4 2.1 5.5 1.3 2.4 -1.0 0.4
Medication: Lisinopril 1.4 1.8 4.1 1.2 1.3 0.3 -2.0
Medication: Atorvastatin 0.5 0.7 1.3 -0.8 -1.1 -0.8 -0.1
Illnesses of father: High blood pressure 1.8 2.2 6.0 2.4 1.0 0.6 -1.3
Alcohol drinker status: Never 0.5 0.5 1.5 0.4 0.5 1.2 0.5
Ever smoked 0.6 1.0 3.3 0.0 -1.8 -0.8 0.3
Basal metabolic rate 0.3 1.8 3.9 -1.2 -0.3 2.0 -1.4
Leg fat percentage (left) 0.3 0.9 1.8 1.4 1.0 0.7 0.6
Arm fat-free mass (left) 0.5 2.5 6.0 -1.2 -0.6 2.5 -1.6
Number of operations (self-reported) 0.0 0.0 0.1 -0.2 0.0 -0.1 -0.3
Average weekly beer plus cider intake 0.3 0.4 0.8 0.9 -0.2 0.9 0.1
Irritability 0.2 0.4 0.9 -0.9 -0.8 -0.2 0.2
Risk taking 1.4 2.1 7.2 -2.7 0.0 -0.7 0.8
Ever had prostate specific antigen (PSA) test 1.0 1.1 2.9 1.7 -0.1 -0.9 -0.9
Fractured/broken bones in last 5 years 0.6 0.7 2.8 1.7 0.2 0.3 -0.1
Age started oral contraceptive pill 3.5 4.4 10.1 0.3 3.2 -0.6 2.6
Diastolic blood pressure, automated reading 0.7 2.1 5.0 1.1 2.2 1.0 -1.0
Ever depressed for a whole week 0.5 0.6 1.1 0.4 -0.0 -1.0 1.1
Unable to work because of sickness or disability 0.4 0.5 1.4 1.2 -0.2 -0.7 -0.4
Commuting to job workplace: Cycle 2.3 2.8 8.9 -0.7 -1.3 0.4 -3.0
Myopia 0.5 0.8 1.1 1.0 -1.1 0.0 -1.0
Vascular/heart problems diagnosed by doctor 2.2 6.0 14.2 -3.8 -1.5 -0.0 2.8
Cholesterol lowering medication 0.8 1.1 2.7 1.6 1.0 -0.3 0.9
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.2 0.3 1.5 -0.6 1.4
Pain experienced in last month 1.4 2.3 3.1 -1.4 1.5 1.4 1.8
Supplements: Calcium 1.9 2.1 3.8 -1.6 -1.0 -1.9 -1.1
Basal cell carcinoma (self-reported) 1.5 1.8 5.0 -2.2 -0.3 0.4 -1.4
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.2 -0.5 -0.1 1.1 0.6
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.3 -0.1 -1.1 1.2 -0.9
Heart disease (siblings) 1.0 1.2 3.8 -0.6 2.0 0.4 0.8
Alcohol drinker status: Previous 0.8 0.9 2.4 0.8 0.2 -0.8 -1.5
Pack years of smoking 0.2 0.3 0.7 0.8 -0.2 0.1 -0.8
Impedance of whole body 1.0 5.0 12.2 3.5 1.0 -2.6 0.4
Leg fat mass (left) 0.2 0.6 1.0 0.9 0.7 1.0 -0.3
Arm predicted mass (left) 0.5 2.6 6.0 -1.3 -0.8 2.5 -1.5