Hub : Genes

VDR

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.2160	0.0490	5.5e-09	0.166	NA	0.144	NA	0.162	1.9e-12	NA	5.9e-11	NA	3.3e-12
2	NTR	Blood	0.0543	0.0155	3.4e-07	0.021	0.019	0.025	0.023	0.022	2.2e-07	4.7e-07	1.6e-08	4.1e-08	7.1e-08
3	TCGA	Ovarian Serous Cystadenocarcinoma	0.1200	0.0490	2.2e-03	0.063	0.016	0.014	NA	0.045	4.5e-05	2.6e-02	3.5e-02	NA	5.4e-04
4	TCGA	Thyroid Carcinoma	0.0640	0.0310	2.0e-03	0.034	0.019	0.033	NA	0.023	2.8e-04	5.2e-03	3.1e-04	NA	2.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.1	1.6	1.1	-1.3	-1.1	-0.7
Bipolar Disorder or Schizophrenia	0.6	1.5	2.9	-1.2	-1.2	-1.7	-0.4
Depressed Affect (Nagel 2018)	0.9	1.9	4.0	2.0	-0.2	-0.4	-1.9
Depression (Nagel 2018)	0.5	0.7	1.7	1.3	0.3	-0.3	-0.9
Intelligence (Savage-Jansen 2018)	0.6	1.7	4.0	-0.8	1.3	-0.7	2.0
Neuroticism (Nagel 2018)	0.5	1.1	3.6	1.9	0.6	0.5	-0.4
Schizophrenia (2018)	0.8	1.6	5.8	-2.4	-0.5	-0.7	0.2
Schizophrenia vs Biploar Disorder	0.4	0.5	1.3	-1.1	0.5	0.7	0.1
Worry (Nagel 2018)	1.1	2.2	3.5	1.5	1.8	0.0	1.9
Alzheimer’s Disease (in mother)	0.5	0.6	1.5	0.6	1.2	0.6	0.2
Alzheimer’s Disease (in father)	0.7	0.8	1.7	-0.8	-0.4	1.3	0.8
Alzheimer’s Disease (including proxy)	0.3	0.5	1.9	0.1	0.1	1.4	0.0
Crohns Disease (2017)	0.3	0.6	2.3	0.2	0.5	-0.1	-1.5
Irritable Bowel Disease (IBD)	0.6	1.4	2.9	-1.3	-0.4	-0.9	-1.7
Ulcerative Colitis (UC)	1.0	1.8	2.9	-1.7	-1.0	-1.4	-1.1
Major Depression (MDD)	0.6	0.7	2.5	0.4	0.5	-1.6	0.0
Reaction Time	0.7	1.2	3.9	-0.4	0.9	-2.0	0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.8	-0.9	0.4	-0.0	0.9
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.8	1.1	2.9	1.7	0.3	0.3	-1.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.2	1.7	4.1	-1.4	-2.0	-0.1	-0.7
Bipolar Disorder (2011)	0.7	0.7	1.4	-1.2	-1.0	-0.7	-0.1
Body Mass Index (BMI) (2010)	0.4	0.6	1.7	-0.7	0.4	0.3	1.3
Coronary Artery Disease (CAD)	0.7	0.9	1.5	-1.0	-0.8	0.4	-1.2
Crohns Disease (2012)	0.2	0.3	0.8	0.1	0.3	-0.4	-0.9
Mean Putamen Volume	0.4	0.4	1.0	-0.1	0.7	0.5	-1.0
Fasting Glucose	0.5	0.6	1.7	0.4	0.4	-0.5	-1.3
HbA1C	0.4	0.4	1.1	0.4	-1.1	-0.1	0.6
HDL Cholesterol	0.4	0.6	2.3	-1.5	-0.2	-0.2	-0.1
LDL Cholesterol	0.8	1.3	3.3	0.5	-1.8	0.3	-1.3
Lupus	1.3	2.0	4.0	-2.0	0.7	1.5	1.2
Neuroticism (2016)	0.2	0.3	0.6	0.6	0.8	-0.5	0.2
Primary Biliary Cirrhosis	0.5	0.7	1.6	0.9	-0.6	-1.3	-0.5
Rheumatoid Arthritis	1.8	2.5	7.4	-0.8	-0.7	2.7	1.1
Schizophrenia (2014)	0.8	1.7	5.2	-2.3	-0.1	-1.3	0.1
Triglycerides	0.2	0.2	0.7	0.3	0.4	0.8	-0.2
Type 2 Diabetes (T2D) (2012)	1.2	1.3	3.6	1.3	-0.2	-1.9	0.2
Ulcerative Colitis	1.3	1.9	3.1	-1.7	-1.1	-1.5	-1.1
Blood Eosinophil Count	0.2	1.3	2.2	1.5	-1.1	-0.3	1.4
Blood Platelet Count	0.6	7.3	19.3	0.5	-2.1	2.2	-4.4
Blood Red Count	2.5	24.4	42.4	-5.3	5.2	-0.4	6.5
Blood White Count	0.3	2.2	3.4	1.8	1.0	1.3	1.8
Heel T-Score	0.9	7.1	21.8	-4.7	-0.7	1.2	2.1
BMI	0.1	0.4	0.4	0.6	0.6	0.6	0.5
Height	0.1	2.4	4.2	1.9	2.0	-0.1	-1.4
Waist Hip Ratio (WHR)	0.2	0.8	2.6	1.6	-0.7	0.2	-0.2
Systolic Blood Pressure	2.2	10.9	31.8	3.3	0.1	0.9	-5.6
Smoking Status	2.9	6.9	14.2	-1.4	-3.8	-3.2	-1.1
Allergy or Eczema	0.2	0.6	1.4	0.6	0.2	-0.8	-1.2
Cardiovascular Disease	1.6	5.4	10.8	3.2	0.6	-0.6	-3.3
Hypothyroidism (self reported)	0.2	0.5	1.1	0.4	0.3	1.0	0.7
Respiratory disease	0.2	0.4	1.0	0.6	0.6	1.0	-0.0
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.3	1.1	-0.9	-0.1	-0.7
Lung FEV1/FVC ratio	0.5	2.6	6.9	-2.6	-1.3	-1.3	0.6
Lung FVC	1.3	6.4	12.7	-3.6	0.2	-0.5	3.5
Neuroticism	0.5	1.1	3.6	1.9	0.2	-0.2	-0.9
Chronotype (morning person)	1.0	2.3	6.2	-0.6	2.5	0.6	1.5
Hair Pigment	0.0	0.7	1.4	1.2	0.0	1.2	0.3
Tanning	0.1	0.9	1.8	-0.9	-0.8	-0.4	-1.3
Hand grip strength (left)	1.9	5.0	14.9	-3.9	0.2	0.8	2.0
Number of treatments/medications taken	1.0	1.7	3.0	1.3	1.7	-1.3	-0.9
Average weekly spirits intake	0.8	1.0	2.4	1.5	-0.8	1.0	-0.3
Sensitivity / hurt feelings	0.3	0.4	1.3	1.1	-0.3	-0.2	-0.6
Frequency of depressed mood in last 2 weeks	0.7	0.9	1.5	1.2	-0.5	-1.1	-0.9
Hearing difficulty/problems: Yes	0.0	0.1	0.2	0.3	-0.1	0.5	-0.1
Relative age of first facial hair	1.1	2.3	5.0	-0.5	1.8	1.0	2.2
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	3.0	-1.7	-0.6	-0.6	0.5
Ever used hormone-replacement therapy (HRT)	2.8	3.6	7.3	-1.2	2.3	0.5	2.7
Ever had hysterectomy (womb removed)	0.3	0.4	0.6	0.7	0.4	-0.7	-0.5
Systolic blood pressure, automated reading	1.3	3.7	5.2	1.9	1.7	1.8	-2.3
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.7	-1.3	-0.9	-1.3	-0.1
Angina	0.3	0.4	1.1	1.0	0.4	0.0	-0.5
Medication for hormone replacement therapy	0.4	0.4	1.2	1.1	-0.2	0.7	-0.2
Vitamin and mineral supplements	0.9	1.3	2.3	0.9	-1.4	1.5	-0.3
Supplements: Zinc	1.0	1.1	2.3	0.1	-0.2	-1.5	-1.4
Medication: Co-codamol	1.3	1.5	4.8	-0.6	2.2	0.5	-0.7
Medication: Metformin	1.2	1.7	3.7	1.0	-1.9	-1.0	-1.1
Diabetes (father)	0.3	0.4	0.9	-0.8	0.3	-1.0	-0.2
Diabetes (mother)	1.0	1.3	3.3	0.5	1.8	0.9	1.0
Severe depression (siblings)	1.2	1.3	2.5	0.8	1.6	-0.3	1.4
Pack years adult smoking proportion	0.6	0.9	1.6	1.2	-0.9	-0.1	-1.2
Impedance of leg (right)	1.0	4.7	13.3	3.6	-0.0	-2.3	-0.3
Leg fat-free mass (left)	0.3	1.7	3.1	-1.2	-0.0	1.8	-1.5
Trunk fat percentage	0.6	2.6	6.3	2.5	1.9	0.6	0.1
Hand grip strength (right)	1.1	2.9	10.4	-3.2	0.3	0.3	1.0
Townsend deprivation index at recruitment	0.9	1.3	2.3	0.7	-1.5	-1.3	-0.8
Current tobacco smoking	0.7	1.1	1.8	-0.6	-1.3	-0.8	-1.3
Average weekly fortified wine intake	0.3	0.4	1.0	-0.0	-0.6	-1.0	-0.5
Maternal smoking around birth	0.5	0.8	1.3	1.0	1.1	-0.9	0.0
Fed-up feelings	1.0	1.8	3.5	1.5	-0.3	-1.0	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	2.5	1.5	-1.4	-0.3	-1.6
Relative age voice broke	0.7	1.0	2.2	-0.5	1.5	0.4	1.3
Taking other prescription medications	0.4	0.7	1.4	1.2	0.5	-1.0	-0.3
Age when periods started (menarche)	1.0	2.3	5.3	2.3	1.7	0.7	0.8
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.9	-0.0	-1.2	-1.7	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.8	-1.7	0.0	0.9	0.1
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	4.2	-2.1	1.1	-0.3	1.4
Qualifications: CSEs or equivalent	2.1	2.8	5.9	1.4	-2.4	-0.4	-1.8
Serious illness, injury or assault to yourself	1.2	1.4	2.8	1.7	0.5	-1.4	-0.8
High blood pressure	2.3	6.5	11.6	3.4	2.0	0.3	-3.2
Hayfever, allergic rhinitis or eczema	0.7	1.6	3.8	1.0	-0.5	-1.1	-1.9
Multivitamins +/- minerals	1.3	1.6	5.0	-0.5	0.8	-2.2	0.7
Stomach or abdominal pain in last month	1.0	1.3	2.9	-0.7	-1.1	-0.6	-1.7
Supplements: Glucosamine	1.0	1.3	4.5	-2.1	-0.3	0.6	-0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.7	0.3	0.8	-0.1	-0.2
Medication: Atenolol	1.0	1.2	4.4	0.0	2.1	0.7	0.4
Medication: Levothyroxine sodium	0.5	0.8	1.3	1.1	1.1	0.6	-0.8
Sitting height	0.3	2.3	5.6	0.5	1.7	0.4	-2.4
Chronic bronchitis/emphysema (father)	0.3	0.3	1.2	-0.1	0.3	1.1	-0.2
High blood pressure (mother)	5.3	7.5	13.4	3.0	-0.7	-2.6	-3.7
Body mass index (BMI)	0.2	0.7	2.6	-0.1	0.2	1.6	-0.0
Impedance of leg (left)	0.7	3.5	9.9	3.1	-0.1	-2.0	0.4
Leg predicted mass (left)	0.3	1.7	3.0	-1.1	-0.1	1.7	-1.6
Trunk fat mass	0.4	1.8	3.6	1.9	1.5	1.0	-0.4
Waist circumference	0.3	1.2	3.2	1.2	0.0	1.8	-0.2
Number of incorrect matches in round	1.4	2.3	7.6	-0.7	0.7	0.9	2.8
Past tobacco smoking	0.7	1.2	2.2	-0.3	1.4	1.5	-0.9
Alcohol usually taken with meals	0.6	1.0	1.9	-0.7	-1.2	0.0	-1.4
Nervous feelings	0.9	1.7	3.5	1.6	0.9	-0.1	1.9
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	3.5	1.8	-0.5	-1.9	-0.9
Hearing difficulty/problems with background noise	1.1	1.7	3.3	-0.5	1.7	0.4	1.8
Hair/balding pattern: Pattern 2	2.3	2.9	4.8	-2.2	-1.0	-1.8	-1.7
Had menopause	1.6	2.0	2.9	1.3	1.7	1.3	1.4
Had other major operations	0.1	0.1	0.1	-0.1	0.1	-0.4	-0.3
Forced vital capacity (FVC)	0.7	2.9	8.4	-2.9	-1.4	-0.5	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.0	-1.3	0.7	1.4	0.4
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	5.4	0.7	0.3	-2.3	0.2
Qualifications: None of the above	0.6	1.2	3.5	0.9	1.9	-0.0	0.8
Financial difficulties in last 2 years	0.9	1.3	1.8	1.0	-1.3	-0.7	-1.4
Mouth/teeth dental problems	0.7	1.0	1.5	-1.1	-1.1	-1.2	-0.5
Heart attack	0.4	0.5	1.3	-0.1	0.3	1.1	0.7
Allergy	0.2	0.5	1.1	-0.6	0.2	0.6	1.1
Pain all over the body in last month	0.7	0.7	1.4	-1.2	-0.7	-0.8	-0.5
Diabetes (self-reported)	0.8	1.2	2.1	1.1	-1.5	-0.9	-0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.0	-0.4	0.1	-1.0	-0.7
Medication: Ramipril	2.1	2.8	4.6	2.1	-0.9	-1.2	-2.0
Medication: Simvastatin	0.9	1.3	4.6	2.1	-0.0	-0.2	-0.9
Fluid intelligence score	0.6	1.2	3.6	-0.4	0.9	0.2	1.9
Illnesses of siblings	0.3	0.4	1.3	-0.1	-1.2	-0.2	-0.0
Neuroticism score	0.4	0.8	2.6	1.6	0.1	-0.6	-0.5
Weight	0.2	1.0	3.1	0.2	0.0	1.8	-1.0
Impedance of arm (right)	1.5	6.9	14.0	3.7	2.6	-2.4	1.2
Arm fat percentage (right)	0.3	1.3	2.9	1.7	1.4	0.4	0.4
Trunk fat-free mass	0.5	2.6	5.0	-1.8	-0.6	2.2	-1.4
Hip circumference	0.3	1.1	2.3	0.8	0.1	1.5	-1.2
Time employed in main current job	0.5	0.6	1.8	0.4	1.3	-0.5	-0.2
Alcohol intake versus 10 years previously	1.2	1.8	4.1	2.0	1.3	-1.1	-0.6
Father’s age at death	0.0	0.0	0.1	-0.2	-0.3	0.1	0.1
Worrier / anxious feelings	0.9	1.7	3.5	1.6	1.9	-0.5	0.6
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.8	1.3	-0.2	-0.9	-2.0
Falls in the last year	1.2	1.6	4.7	2.2	-0.9	0.6	-0.8
Hair/balding pattern: Pattern 3	1.4	2.0	3.5	1.9	1.5	-1.5	0.5
Number of live births	0.4	0.6	0.8	0.6	0.9	0.7	0.9
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	12.6	-3.6	-1.5	-0.3	1.2
Pulse rate	0.5	0.8	1.5	1.2	0.3	-0.9	1.0
Happiness	0.5	0.6	1.4	1.0	0.3	-1.2	0.1
Noisy workplace	0.7	0.9	2.1	-1.4	-0.5	-0.6	-1.0
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.1	-0.5	-1.8	0.2	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	2.3	0.0	-1.5	-0.8	-0.9
Mouth/teeth dental problems: Dentures	0.6	1.0	1.9	0.4	1.3	-0.4	1.4
Asthma	0.1	0.2	0.3	-0.2	-0.5	0.4	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.7	1.6	1.6	0.2	0.6
Medication: Cholesterol lowering	2.0	3.0	6.9	1.6	-1.6	-0.4	-2.6
Depression (self-reported)	1.1	1.4	2.9	1.2	1.1	-0.2	1.7
Medication: Lansoprazole	0.2	0.2	0.3	0.4	0.5	0.1	0.5
Prospective memory result	0.2	0.2	0.7	0.1	0.4	0.9	-0.2
Lung cancer (father)	2.2	2.6	6.8	1.0	2.6	0.4	1.6
Illnesses of mother	2.4	2.9	6.2	-2.5	-1.2	0.7	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	10.1	-3.2	-1.3	-0.6	0.6
Pulse wave Arterial Stiffness index	1.4	1.6	5.3	-0.7	0.3	2.3	-0.8
Impedance of arm (left)	1.2	5.7	10.1	3.2	2.1	-2.8	0.8
Arm fat mass (right)	0.2	0.7	1.2	1.0	1.1	0.8	-0.1
Trunk predicted mass	0.5	2.6	4.9	-1.8	-0.5	2.2	-1.4
Standing height	0.1	1.0	3.6	0.3	0.1	0.3	-1.9
Length of working week for main job	0.4	0.4	1.3	0.2	1.1	0.6	-0.3
Exposure to tobacco smoke at home	1.9	2.1	4.1	1.8	-2.0	-0.4	-1.0
Breastfed as a baby	1.6	2.0	6.2	-2.5	-0.9	0.9	0.0
Tense / ‘highly strung’	0.8	1.4	3.3	-0.1	1.8	-0.2	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	0.6	-0.3	0.0	0.6
Hair/balding pattern: Pattern 4	0.3	0.8	1.4	-1.2	-0.5	0.4	-1.2
Birth weight of first child	0.2	0.4	0.9	0.8	-0.2	1.0	-0.2
Peak expiratory flow (PEF)	2.6	6.0	17.5	-4.2	-2.6	0.0	0.2
Pulse wave reflection index	3.0	3.7	6.5	-1.6	-1.0	2.5	-2.2
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.1	0.2	-1.1	-0.9	-0.6
Loud music exposure frequency	0.4	0.4	1.0	1.0	-0.7	-0.1	-0.5
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.2	0.8	-1.6	-0.8	-1.8
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.6	1.6	0.2	1.1	-1.0
Blood clot in the leg (DVT)	0.5	0.6	0.8	0.2	-0.8	0.9	-0.9
Medication: Paracetamol	1.1	1.9	3.1	1.6	1.8	-1.3	0.1
Headache pain in last month	1.8	3.1	6.2	2.3	-0.8	-0.4	-2.5
Medication for cholesterol, blood pressure or diabetes	2.4	3.9	10.2	-3.2	-0.3	-0.6	2.3
Glaucoma (self-reported)	0.7	0.9	2.7	1.6	-0.3	0.4	-0.7
Gout (self-reported)	1.5	2.1	6.6	-0.2	2.6	-0.3	1.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.7	0.5	0.8	0.8	0.4
Medication: Amlodipine	3.5	4.9	9.9	2.8	-0.3	1.3	-3.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	-0.4	0.5	0.0	0.3
Birth weight	0.3	0.7	1.8	-0.7	0.6	0.3	1.3
Chronic bronchitis/emphysema (mother)	1.0	1.1	1.7	1.3	0.8	1.1	0.9
High blood pressure (siblings)	0.5	0.7	2.0	0.8	1.4	0.4	-0.1
Forced vital capacity (FVC), Best measure	0.5	2.0	5.8	-2.4	-1.1	-0.7	0.6
Body fat percentage	0.4	1.7	4.7	2.2	1.4	0.5	0.1
Leg fat percentage (right)	0.3	1.2	3.9	2.0	0.7	0.5	-0.0
Arm fat-free mass (right)	0.6	2.9	4.6	-1.9	-1.0	2.1	-1.6
Exposure to tobacco smoke outside home	0.3	0.4	1.1	1.0	-0.3	-0.4	0.3
Comparative body size at age 10	0.6	1.7	5.3	-0.8	-0.2	0.7	2.3
Number of full brothers	0.6	0.8	1.9	0.7	-0.6	-1.4	0.7
Worry too long after embarrassment	0.3	0.6	1.1	1.1	0.9	0.2	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.6	0.2	0.7	-1.2	0.3
Wheeze or whistling in the chest in last year	1.1	2.0	4.3	2.1	-0.4	-1.5	-1.1
Number of children fathered	1.5	1.6	2.9	-1.2	-1.7	1.4	0.6
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.6	7.2	0.1	1.5	1.1	2.7
Age at first live birth	0.5	0.8	2.1	-0.4	-1.0	1.5	-0.1
Pulse wave peak to peak time	1.5	1.7	5.6	0.9	-0.4	-2.4	0.6
Health satisfaction	1.4	1.9	4.7	2.2	-0.4	0.5	-1.5
Shortness of breath walking on level ground	2.4	2.9	5.5	2.2	-1.2	0.0	-2.3
Qualifications: College or University degree	0.1	0.4	0.8	-0.9	-0.3	0.6	-0.7
Eye problems/disorders: None of the above	0.2	0.2	0.4	-0.7	0.5	-0.3	-0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	-0.1	-0.2	-0.6	-0.8
Emphysema/chronic bronchitis	0.9	1.0	1.6	1.3	0.8	-0.8	1.0
Medication for pain relief, constipation, heartburn	1.4	2.3	4.0	-2.0	-1.9	1.3	0.2
Neck or shoulder pain in last month	0.6	0.8	1.4	-0.2	-1.0	-1.0	-1.2
Medication: Blood pressure	2.3	4.1	10.1	3.2	1.2	0.2	-2.2
Angina (self-reported)	0.3	0.4	1.2	1.1	0.2	0.3	-0.5
Migraine (self-reported)	1.4	1.7	6.0	2.5	0.3	0.7	-0.6
Medication: Ibuprofen	1.3	1.5	3.4	1.3	1.8	0.4	0.9
Medication: Allopurinol	1.0	1.3	4.8	0.2	2.2	-0.7	-0.0
Medication: Omeprazole	0.5	0.6	1.2	-0.0	0.9	-1.1	0.6
Medication: Seretide 50 evohaler	0.5	0.6	1.7	-0.2	-0.5	-0.7	1.3
Mean time to correctly identify matches	1.7	3.3	5.6	-0.8	2.4	-2.4	1.2
Heart disease (mother)	0.4	0.5	1.1	0.0	0.5	-0.8	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.5	0.7	-1.2	0.5	-0.2
Whole body fat mass	0.3	1.1	1.7	1.3	1.1	1.1	-0.4
Leg fat mass (right)	0.2	0.9	1.9	1.4	0.5	0.9	-0.7
Arm predicted mass (right)	0.5	2.8	5.1	-1.5	-1.0	2.2	-1.7
Pulse rate, automated reading	0.8	2.5	3.7	1.9	1.9	-1.5	0.6
Alcohol intake frequency.	0.6	1.5	2.4	1.5	0.1	-1.0	-1.6
Comparative height size at age 10	0.1	0.4	1.2	-1.1	-0.0	0.4	0.3
Number of full sisters	1.5	1.8	4.0	0.5	2.0	0.4	1.6
Suffer from ‘nerves’	0.6	1.0	3.5	1.9	-0.3	0.4	-0.2
Overall health rating	3.4	7.3	13.4	3.7	-1.7	-0.8	-3.5
Chest pain or discomfort	1.8	2.6	6.1	2.5	-0.2	-1.2	-1.7
Had major operations	0.5	0.6	1.4	0.8	0.3	1.2	0.5
Age at last live birth	0.3	0.5	0.7	0.8	-0.9	0.8	0.2
Family relationship satisfaction	0.3	0.3	0.8	-0.7	-0.9	0.1	0.1
Leg pain on walking	0.9	1.1	2.3	1.5	0.1	0.1	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.0	-1.0	-1.0	-0.1	0.5
Commuting to job workplace: Car/motor vehicle	2.0	2.3	5.5	-0.7	1.6	1.0	2.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.3	-0.5	1.0	1.5	1.2
Medication: Aspirin	0.5	0.6	1.3	1.1	-0.1	-0.1	-1.1
Supplements: Vitamin C	1.0	1.2	3.7	-0.4	0.7	-1.9	-0.6
Knee pain experienced in last month	3.0	4.7	7.5	2.7	-1.6	-1.2	-2.7
Hypertension (Self-reported)	2.1	5.9	10.8	3.3	2.0	0.5	-2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	-0.5	0.3	0.4	0.2
Illnesses of father: Heart disease	2.3	3.2	6.1	-2.5	-1.2	-1.5	-1.8
Illnesses of siblings: Diabetes	0.1	0.1	0.2	-0.1	-0.3	-0.5	0.2
Smoking status: Previous	1.1	1.7	4.8	-0.3	-0.9	-2.2	1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	7.2	0.7	-2.7	0.3	-2.0
Whole body fat-free mass	0.4	2.4	4.8	-1.7	-0.4	2.2	-1.3
Leg fat-free mass (right)	0.4	1.9	4.0	-1.7	-0.1	2.0	-1.0
Arm fat percentage (left)	0.3	1.0	2.1	1.5	1.3	0.2	0.3
Average weekly red wine intake	1.4	2.1	7.5	-2.7	-0.7	-0.5	0.2
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.7	0.2	-0.4	0.9	0.4
Mood swings	0.5	0.8	1.9	1.4	-0.0	0.4	-1.1
Loneliness, isolation	3.1	4.3	10.1	1.1	-1.6	-1.8	-3.2
Long-standing illness, disability or infirmity	0.5	0.7	2.2	0.5	-0.5	-0.3	-1.5
Ever had bowel cancer screening	0.9	1.1	3.0	1.1	1.7	-0.5	0.1
Diabetes diagnosed by doctor	0.6	1.0	2.1	1.0	-1.4	-0.6	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.5	-1.1	-1.2	0.0	-0.9
Friendships satisfaction	0.6	0.8	1.5	1.2	0.3	-1.2	0.0
Qualifications: nursing, teaching	0.3	0.5	1.4	-1.2	0.2	0.7	-0.4
Commuting to job workplace: Walk	1.1	1.1	2.0	-0.6	-1.4	-1.4	-0.7
Eye problems/disorders: Cataract	0.1	0.1	0.4	0.3	-0.6	-0.1	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	0.4	0.2	0.4	0.7
Medication for cholesterol	1.0	1.6	3.2	-1.8	-0.1	0.4	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.2	1.8	-0.1	-1.1	-0.5
Back pain experienced in last month	1.5	2.2	4.6	-0.5	-2.0	0.1	-2.1
Mineral and other dietary supplements	0.8	1.0	3.4	1.8	-0.7	0.5	-0.1
Breast cancer (self-reported)	0.4	0.5	1.4	-0.0	-0.4	-0.6	-1.2
Asthma (self-reported)	0.1	0.1	0.2	-0.2	-0.3	0.5	-0.5
Osteoporosis (self-reported)	2.2	2.8	8.8	-0.4	-3.0	-1.2	-0.8
Osteoarthritis (self-reported)	0.3	0.4	1.1	0.7	0.3	0.1	-1.0
Medication: Aspirin	0.4	0.5	1.0	1.0	-0.6	-0.1	-0.7
Medication: Gliclazide	0.9	1.0	3.1	1.8	-0.4	0.0	-0.8
Illnesses of father: None of the above (group 1)	1.0	1.2	4.0	0.9	0.2	-0.2	2.0
Smoking status: Current	0.7	1.1	2.2	-0.8	-1.5	-0.4	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	7.3	-2.7	0.2	-1.3	1.3
Whole body water mass	0.4	2.5	4.7	-1.6	-0.4	2.2	-1.5
Leg predicted mass (right)	0.4	1.9	3.8	-1.6	-0.1	1.9	-1.1
Arm fat mass (left)	0.2	0.7	1.1	0.9	1.0	0.8	-0.2
Number of self-reported non-cancer illnesses	1.2	2.0	5.5	2.3	1.3	-0.3	-1.0
Average weekly champagne plus white wine intake	0.8	1.1	3.7	0.5	-0.5	1.9	0.1
Miserableness	0.6	1.0	3.5	1.9	-0.5	0.1	-0.6
Guilty feelings	1.0	1.4	4.0	0.8	-0.7	-2.0	-0.7
Wears glasses or contact lenses	2.7	3.1	10.5	0.8	3.2	0.0	1.1
Ever taken oral contraceptive pill	0.8	0.9	2.2	0.6	1.5	-1.0	-0.3
Hearing aid user	2.5	2.8	7.3	1.6	0.8	2.7	0.7
Mother’s age at death	1.6	2.1	3.2	1.1	1.5	1.3	1.8
Financial situation satisfaction	0.4	0.6	1.0	0.7	0.2	-0.8	-1.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.3	-0.5	-0.6	0.2	1.1
Commuting to job workplace: Public transport	3.2	3.8	8.7	3.0	-1.6	-1.4	-1.4
Eye problems/disorders: Glaucoma	0.8	0.9	2.1	1.5	-0.2	1.1	-0.7
Medication: Blood pressure	1.7	3.2	8.0	2.1	0.5	-0.2	-2.8
Pain type(s) experienced in last month: Hip pain	0.4	0.6	1.3	-0.5	-0.6	0.6	-1.1
Supplements: Fish oil (including cod liver oil)	2.3	3.0	6.3	-2.5	1.7	0.4	1.6
High cholesterol (Self-reported)	0.5	0.8	2.1	1.4	-0.5	-0.7	-0.8
Medication: Bendroflumethiazide	1.6	2.4	7.5	0.5	-0.8	-1.1	-2.7
Medication: Paracetamol	1.4	2.1	5.5	1.3	2.4	-1.0	0.4
Medication: Lisinopril	1.4	1.8	4.1	1.2	1.3	0.3	-2.0
Medication: Atorvastatin	0.5	0.7	1.3	-0.8	-1.1	-0.8	-0.1
Illnesses of father: High blood pressure	1.8	2.2	6.0	2.4	1.0	0.6	-1.3
Alcohol drinker status: Never	0.5	0.5	1.5	0.4	0.5	1.2	0.5
Ever smoked	0.6	1.0	3.3	0.0	-1.8	-0.8	0.3
Basal metabolic rate	0.3	1.8	3.9	-1.2	-0.3	2.0	-1.4
Leg fat percentage (left)	0.3	0.9	1.8	1.4	1.0	0.7	0.6
Arm fat-free mass (left)	0.5	2.5	6.0	-1.2	-0.6	2.5	-1.6
Number of operations (self-reported)	0.0	0.0	0.1	-0.2	0.0	-0.1	-0.3
Average weekly beer plus cider intake	0.3	0.4	0.8	0.9	-0.2	0.9	0.1
Irritability	0.2	0.4	0.9	-0.9	-0.8	-0.2	0.2
Risk taking	1.4	2.1	7.2	-2.7	0.0	-0.7	0.8
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.9	1.7	-0.1	-0.9	-0.9
Fractured/broken bones in last 5 years	0.6	0.7	2.8	1.7	0.2	0.3	-0.1
Age started oral contraceptive pill	3.5	4.4	10.1	0.3	3.2	-0.6	2.6
Diastolic blood pressure, automated reading	0.7	2.1	5.0	1.1	2.2	1.0	-1.0
Ever depressed for a whole week	0.5	0.6	1.1	0.4	-0.0	-1.0	1.1
Unable to work because of sickness or disability	0.4	0.5	1.4	1.2	-0.2	-0.7	-0.4
Commuting to job workplace: Cycle	2.3	2.8	8.9	-0.7	-1.3	0.4	-3.0
Myopia	0.5	0.8	1.1	1.0	-1.1	0.0	-1.0
Vascular/heart problems diagnosed by doctor	2.2	6.0	14.2	-3.8	-1.5	-0.0	2.8
Cholesterol lowering medication	0.8	1.1	2.7	1.6	1.0	-0.3	0.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.2	0.3	1.5	-0.6	1.4
Pain experienced in last month	1.4	2.3	3.1	-1.4	1.5	1.4	1.8
Supplements: Calcium	1.9	2.1	3.8	-1.6	-1.0	-1.9	-1.1
Basal cell carcinoma (self-reported)	1.5	1.8	5.0	-2.2	-0.3	0.4	-1.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	-0.5	-0.1	1.1	0.6
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.3	-0.1	-1.1	1.2	-0.9
Heart disease (siblings)	1.0	1.2	3.8	-0.6	2.0	0.4	0.8
Alcohol drinker status: Previous	0.8	0.9	2.4	0.8	0.2	-0.8	-1.5
Pack years of smoking	0.2	0.3	0.7	0.8	-0.2	0.1	-0.8
Impedance of whole body	1.0	5.0	12.2	3.5	1.0	-2.6	0.4
Leg fat mass (left)	0.2	0.6	1.0	0.9	0.7	1.0	-0.3
Arm predicted mass (left)	0.5	2.6	6.0	-1.3	-0.8	2.5	-1.5