TWAS hub - RPAP3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0444	0.0228	0.0260	0.034	0.011	0.035	0.022	0.026	7.3e-06	8.1e-03	4.2e-06	2.3e-04	6.9e-05
2	NTR	Blood	0.0208	0.0089	0.0048	-0.001	0.003	0.000	0.003	-0.001	6.1e-01	3.6e-02	4.1e-01	2.3e-02	7.8e-01
3	YFS	Blood	0.1645	0.0280	0.0000	0.123	0.095	0.114	0.124	0.122	3.9e-38	1.5e-29	2.8e-35	3.0e-38	7.5e-38

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Exposure to tobacco smoke at home	5.1	5.7	8.9	-3.0	-0.2	-2.9
Myopia	4.4	6.3	8.2	-2.3	-2.9	-2.4
Vascular/heart problems diagnosed by doctor	4.0	10.8	18.2	-3.6	1.2	-4.3
Blood Red Count	3.7	35.4	71.7	3.0	8.5	5.0
Alcohol intake versus 10 years previously	3.7	5.5	5.8	2.4	-2.3	2.4
Medication: Allopurinol	3.6	4.8	5.7	2.3	-1.8	2.4
Diabetes (mother)	3.5	4.5	8.1	2.8	-0.3	2.3
Medication: Simvastatin	3.4	5.1	13.2	1.4	-3.6	-0.0
Gout (self-reported)	3.4	4.7	6.6	2.0	-1.8	2.6
High blood pressure	3.3	9.2	16.1	3.3	-0.6	4.0
Medication: Aspirin	3.3	4.4	12.9	0.2	-3.6	-0.5
Cardiovascular Disease	3.1	10.2	14.9	3.9	-1.7	3.6
Medication: Cholesterol lowering	2.9	4.5	8.9	2.1	-3.0	0.2
Medication: Aspirin	2.9	3.8	10.0	-0.7	-3.2	-1.0
Miserableness	2.9	5.0	5.5	-2.3	-2.1	-2.4
Tinnitus: Yes, now most or all of the time	2.9	3.4	4.4	-2.1	1.7	-1.6
Hypertension (Self-reported)	2.8	7.7	13.3	3.1	-0.6	3.6
Ever taken oral contraceptive pill	2.8	3.1	7.6	-1.3	-0.1	-2.8
Blood Platelet Count	2.7	31.7	94.9	-0.0	-9.7	0.6
Medication for cholesterol	2.6	4.0	10.7	-1.0	3.3	-0.6
Eye problems/disorders: None of the above	2.5	2.9	7.8	0.6	-2.8	0.6
Qualifications: nursing, teaching	2.5	3.9	4.8	-2.2	-1.5	-2.2
Medication for hormone replacement therapy	2.4	2.7	6.8	1.0	-2.6	0.5
Medication for cholesterol, blood pressure or diabetes	2.4	4.0	6.5	-2.1	2.6	-0.9
Mineral and other dietary supplements	2.4	3.2	6.9	2.6	0.8	1.5
High blood pressure (mother)	2.3	3.3	9.3	0.7	-3.0	-0.2
Medication: Blood pressure	2.3	4.1	8.2	1.7	-2.9	1.1
Medication: Lisinopril	2.3	3.0	3.6	1.4	-1.9	1.9
Supplements: Fish oil (including cod liver oil)	2.2	2.8	5.6	-2.4	-0.2	-1.7
Average weekly beer plus cider intake	2.2	3.2	5.1	2.1	-0.3	2.3
Supplements: Calcium	2.2	2.4	3.4	-1.5	-1.8	-1.2
Reaction Time	2.1	4.0	6.8	-2.6	0.1	-2.3
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	3.4	1.8	0.4	1.8
Qualifications: A levels/AS levels or equivalent	2.1	4.6	7.7	-2.5	-0.0	-2.8
Chest pain or discomfort	2.1	3.0	5.5	1.7	-0.9	2.3
Medication: Bendroflumethiazide	2.1	3.2	4.6	-2.0	-2.1	-1.1
Alzheimer’s Disease (in mother)	2.0	2.4	7.0	0.0	2.6	0.2
Ever used hormone-replacement therapy (HRT)	2.0	2.5	4.4	2.1	-0.5	1.7
Had major operations	2.0	2.3	4.8	-1.3	-0.8	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	5.8	2.4	-0.5	1.0
Fractured/broken bones in last 5 years	2.0	2.6	3.8	-1.9	-0.5	-1.9
Diastolic blood pressure, automated reading	2.0	6.1	10.5	2.0	2.0	3.2
Bipolar Disorder (2011)	1.9	1.9	3.7	-1.9	-1.0	-1.0
Had menopause	1.8	2.3	4.7	2.2	-0.2	1.4
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	6.7	-2.6	0.1	-1.4
Angina (self-reported)	1.8	2.4	6.4	0.4	-2.5	-0.8
Average weekly champagne plus white wine intake	1.8	2.5	4.7	-1.3	1.1	-2.2
Mean Putamen Volume	1.7	2.0	3.1	-1.7	1.8	-0.2
Allergy or Eczema	1.7	4.5	7.0	2.6	1.8	1.9
Systolic blood pressure, automated reading	1.7	4.9	7.7	2.8	0.5	2.6
Angina	1.7	2.2	5.9	0.3	-2.4	-0.8
Fed-up feelings	1.7	3.1	5.6	-1.8	-2.4	-0.7
Hair/balding pattern: Pattern 3	1.7	2.5	5.7	-2.4	-0.1	-1.4
Mouth/teeth dental problems: Dentures	1.7	2.8	4.9	1.6	2.2	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	5.1	-0.7	-2.3	-1.0
Heart disease (mother)	1.7	2.1	4.9	0.5	-2.2	1.0
Number of self-reported non-cancer illnesses	1.7	2.9	4.2	2.0	-1.6	1.3
High cholesterol (Self-reported)	1.7	3.0	4.9	1.9	-2.2	-0.8
Number of operations (self-reported)	1.7	2.5	6.9	-0.2	-2.6	-0.8
Multivitamins +/- minerals	1.6	2.0	3.9	-2.0	-0.3	-1.4
Noisy workplace	1.6	2.0	4.9	2.2	-0.4	1.0
Medication: Lansoprazole	1.6	1.9	3.5	1.9	-0.3	1.4
Back pain experienced in last month	1.6	2.4	3.6	-1.9	-0.5	-1.8
Major Depression (MDD)	1.5	1.8	4.7	-0.7	2.2	-0.4
Hayfever, allergic rhinitis or eczema	1.5	3.3	4.9	2.2	1.7	1.4
Hair/balding pattern: Pattern 2	1.5	1.9	3.1	1.8	1.2	1.0
Basal cell carcinoma (self-reported)	1.5	1.7	2.0	-1.4	-1.3	-1.2
Alzheimer’s Disease (including proxy)	1.4	2.1	6.0	-0.0	2.4	0.5
Fasting Glucose	1.4	1.7	2.7	1.6	1.5	0.1
Ulcerative Colitis	1.4	2.1	2.8	1.7	-0.9	1.6
Average weekly spirits intake	1.4	1.8	3.0	1.7	-1.4	-0.7
Townsend deprivation index at recruitment	1.4	1.9	3.1	1.2	-1.8	1.1
Length of working week for main job	1.4	1.6	2.4	-1.5	-1.1	-1.1
Suffer from ‘nerves’	1.4	2.2	5.4	-0.9	-2.3	-0.7
Smoking status: Previous	1.4	2.0	2.4	-1.5	-1.3	-1.5
HbA1C	1.3	1.5	1.8	-1.0	-1.3	-1.3
Neuroticism (2016)	1.3	1.9	3.7	-1.0	-1.0	-1.9
Chronic bronchitis/emphysema (father)	1.3	1.5	2.9	-1.7	1.3	-0.1
Alcohol usually taken with meals	1.3	2.1	4.7	-1.1	2.2	-0.5
Illnesses of siblings	1.3	1.8	3.8	-1.1	1.9	-0.7
Lung cancer (father)	1.3	1.6	4.5	-0.1	-2.1	-0.4
Medication: Amlodipine	1.3	1.8	3.7	0.8	-1.9	1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.7	-1.2	1.6	-0.4
Breast cancer (self-reported)	1.3	1.5	3.3	-1.8	-0.6	-0.9
Medication: Gliclazide	1.3	1.5	2.3	1.5	-1.0	1.1
Hand grip strength (left)	1.2	3.2	9.2	-0.4	3.0	0.5
Maternal smoking around birth	1.2	1.8	3.7	1.9	-0.8	1.0
Medication: Atenolol	1.2	1.5	3.9	-0.7	-2.0	-0.4
Past tobacco smoking	1.2	2.1	4.3	1.1	0.9	2.1
Financial difficulties in last 2 years	1.2	1.6	2.8	0.3	-1.3	1.7
Mouth/teeth dental problems	1.2	1.8	3.5	-1.0	-1.9	-0.9
Medication: Ibuprofen	1.2	1.4	2.5	-0.8	-1.6	-1.0
Long-standing illness, disability or infirmity	1.2	1.9	5.2	0.7	-2.3	-0.2
Friendships satisfaction	1.2	1.4	2.1	0.8	-1.4	1.2
Heart disease (siblings)	1.2	1.4	2.9	1.2	-1.7	-0.2
Hand grip strength (right)	1.1	3.0	8.1	-0.0	2.9	1.0
Stomach or abdominal pain in last month	1.1	1.4	2.7	1.6	0.7	1.0
Time employed in main current job	1.1	1.2	1.4	1.1	-1.2	1.1
Pulse wave Arterial Stiffness index	1.1	1.2	1.6	0.9	1.1	1.3
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.0	0.9	0.0	1.7
Pulse wave peak to peak time	1.1	1.4	1.7	-0.9	-1.3	-1.2
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.0	1.4	0.2	1.3
Bipolar Disorder (2018)	1.0	1.6	3.5	-1.1	0.3	-1.9
Smoking Status	1.0	2.4	5.1	-1.2	-0.9	-2.3
Supplements: Zinc	1.0	1.1	2.2	-1.0	-1.5	0.3
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	1.6	1.3	1.1	1.1
Medication: Ramipril	1.0	1.3	2.3	0.7	-1.5	1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.0	-1.4	0.5	-1.2
Medication for pain relief, constipation, heartburn	1.0	1.8	4.5	0.0	2.1	0.9
Leg pain on walking	1.0	1.3	2.1	1.5	-1.0	0.9
Osteoporosis (self-reported)	1.0	1.3	2.3	-1.2	-0.1	-1.5
Depressed Affect (Nagel 2018)	0.9	1.8	2.8	-1.1	-1.7	-1.2
Systolic Blood Pressure	0.9	4.7	5.8	2.4	-1.8	2.3
Taking other prescription medications	0.9	1.3	4.0	0.1	-2.0	0.2
Heart attack	0.9	1.2	1.8	1.2	-1.4	-0.3
Happiness	0.9	1.0	2.7	-1.6	-0.5	-0.4
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.7	0.5	-0.7	1.7
Illness, injury, bereavement, stress in last 2 years	0.9	1.0	3.0	1.7	-0.2	0.3
Eye problems/disorders: Cataract	0.9	1.1	2.9	-0.4	1.7	-0.5
Medication: Blood pressure	0.9	1.7	2.6	0.6	-1.4	1.6
Age started oral contraceptive pill	0.9	1.1	1.5	1.2	-0.6	1.2
Commuting to job workplace: Cycle	0.9	1.1	2.0	0.5	-1.0	1.4
Cholesterol lowering medication	0.9	1.3	2.2	1.2	-1.5	0.1
Heart attack/myocardial infarction (self-reported)	0.9	1.1	1.9	1.4	-1.2	-0.0
Ovarian Cancer	0.8	1.1	1.9	-1.4	-0.7	-0.9
LDL Cholesterol	0.8	1.2	1.8	0.7	-1.3	-1.2
Rheumatoid Arthritis	0.8	1.2	2.0	-1.4	1.1	-0.5
Chronotype (morning person)	0.8	1.9	3.9	1.0	-2.0	0.9
Severe depression (siblings)	0.8	0.8	1.9	0.1	-0.8	1.4
Age when periods started (menarche)	0.8	1.9	3.6	-1.1	-1.9	-0.8
Number of incorrect matches in round	0.8	1.3	1.9	-1.4	0.9	-1.2
Father’s age at death	0.8	1.0	2.6	-1.6	-0.4	-0.5
Worry too long after embarrassment	0.8	1.4	3.7	-0.2	-1.9	-0.6
Age at first live birth	0.8	1.5	2.2	-0.4	-1.5	-1.5
Mean time to correctly identify matches	0.8	1.4	2.1	-1.5	1.0	-1.1
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.1	-0.7	0.5	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.3	0.5	1.5	0.5
Mood swings	0.8	1.5	4.4	-0.2	-2.1	-0.1
Illnesses of father: None of the above (group 1)	0.8	0.9	1.9	-0.8	-0.5	-1.4
Financial situation satisfaction	0.8	1.0	2.1	1.5	-0.9	0.3
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.8	1.1	-0.0	1.3
Ever smoked	0.8	1.4	3.2	-0.3	-1.0	-1.8
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.7	-1.3	0.5	-0.9
Verbal and Numeric Reasoning (VNR)	0.7	1.7	2.9	-0.2	1.7	-1.5
Hypothyroidism (self reported)	0.7	1.6	3.3	-0.4	1.8	-1.1
Number of treatments/medications taken	0.7	1.2	3.6	0.2	-1.9	-0.2
Vitamin and mineral supplements	0.7	0.9	1.3	1.2	0.5	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.3	0.8	-2.1	0.4
Neuroticism score	0.7	1.6	3.1	-1.0	-1.8	-0.8
Health satisfaction	0.7	0.9	2.2	1.5	0.3	0.5
Neck or shoulder pain in last month	0.7	1.0	2.7	-0.1	-1.6	-0.6
Migraine (self-reported)	0.7	0.9	1.4	1.1	-0.2	1.2
Pulse rate, automated reading	0.7	2.2	2.9	1.7	1.0	1.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.3	-0.8	-1.1	0.7
Asthma (self-reported)	0.7	1.3	3.0	-1.7	0.2	-1.0
Smoking status: Current	0.7	1.1	2.0	-0.6	0.9	-1.4
Eye problems/disorders: Glaucoma	0.7	0.8	1.3	-1.0	1.1	-0.4
Medication: Atorvastatin	0.7	0.8	1.8	0.5	-0.7	-1.3
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.7	-0.6	1.9	-1.2
Coronary Artery Disease (CAD)	0.6	0.8	1.8	-0.4	-1.4	0.5
Lupus	0.6	0.8	1.5	1.2	0.7	0.7
Primary Biliary Cirrhosis	0.6	0.9	1.1	0.9	0.9	1.1
Medication: Metformin	0.6	0.8	1.4	1.2	-0.9	0.5
Current tobacco smoking	0.6	1.0	2.0	-0.7	0.7	-1.4
Qualifications: CSEs or equivalent	0.6	0.8	1.7	0.9	-1.3	0.3
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.0	-0.2	-1.4	-0.2
Nervous feelings	0.6	1.1	1.5	-0.9	-1.1	-1.2
Asthma	0.6	1.3	2.8	-1.7	0.1	-1.0
Illnesses of mother	0.6	0.7	1.7	-0.4	1.3	-0.5
Breastfed as a baby	0.6	0.8	1.6	1.3	0.0	0.8
Number of children fathered	0.6	0.6	1.5	1.2	0.6	-0.2
Shortness of breath walking on level ground	0.6	0.7	0.9	1.0	0.8	0.6
Qualifications: College or University degree	0.6	1.8	3.1	-0.8	1.3	-1.8
Medication: Seretide 50 evohaler	0.6	0.7	1.1	1.1	0.7	0.7
Supplements: Vitamin C	0.6	0.7	1.5	-0.4	1.2	0.7
Osteoarthritis (self-reported)	0.6	0.8	1.2	1.1	-0.0	1.1
Wears glasses or contact lenses	0.6	0.7	1.5	1.2	0.2	0.7
Body Mass Index (BMI) (2010)	0.5	0.7	0.9	0.7	1.0	0.7
Impedance of leg (right)	0.5	2.3	5.4	0.9	-2.3	-0.8
Hearing difficulty/problems with background noise	0.5	0.8	1.8	-0.8	-1.3	-0.2
Allergy	0.5	1.3	2.2	-0.9	-1.5	-0.9
Pain all over the body in last month	0.5	0.6	1.7	-0.2	-1.3	0.1
Diabetes (self-reported)	0.5	0.7	1.7	1.3	-0.6	0.2
Impedance of arm (right)	0.5	2.3	5.2	0.2	-2.3	-1.3
Falls in the last year	0.5	0.7	1.9	-0.3	0.3	-1.4
Number of live births	0.5	0.7	1.9	-0.3	1.4	0.1
Pulse rate	0.5	0.9	2.0	-0.0	1.4	0.8
Hair/balding pattern: Pattern 4	0.5	1.1	2.0	1.4	-1.0	0.7
Birth weight of first child	0.5	1.0	1.9	0.9	0.4	1.4
Glaucoma (self-reported)	0.5	0.6	1.1	-1.0	-0.4	-0.8
Birth weight	0.5	1.2	3.1	0.7	0.2	1.8
Forced vital capacity (FVC), Best measure	0.5	1.6	1.9	-1.3	-1.2	-1.4
Comparative body size at age 10	0.5	1.4	3.5	-1.9	-0.6	-0.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.0	-0.9	1.0	0.1
Ever had bowel cancer screening	0.5	0.6	1.0	-0.8	-1.0	-0.2
Diabetes diagnosed by doctor	0.5	0.9	1.8	1.3	-0.8	0.4
Risk taking	0.5	0.7	1.5	-0.6	-1.2	-0.5
Schizophrenia vs Biploar Disorder	0.4	0.6	1.0	-0.9	-1.0	-0.3
Triglycerides	0.4	0.7	1.6	-0.0	-1.3	-0.6
Hearing difficulty/problems: Yes	0.4	0.6	1.3	-0.3	-0.6	-1.1
Ever had hysterectomy (womb removed)	0.4	0.4	1.3	-1.1	0.2	0.0
Had other major operations	0.4	0.5	1.2	-0.4	-1.1	-0.1
Forced vital capacity (FVC)	0.4	1.5	1.6	-1.2	-1.2	-1.3
Fluid intelligence score	0.4	0.9	2.3	0.2	1.5	-0.6
Exposure to tobacco smoke outside home	0.4	0.5	0.8	-0.9	-0.2	-0.9
Alcohol intake frequency.	0.4	1.0	2.2	0.8	-0.2	1.5
Illnesses of father: Heart disease	0.4	0.6	1.2	0.5	0.6	1.1
Illnesses of siblings: Diabetes	0.4	0.5	0.9	0.0	-0.9	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.2	-1.1	-0.9	-0.8
Loneliness, isolation	0.4	0.6	1.3	-1.2	-0.5	-0.5
Alcohol drinker status: Never	0.4	0.4	1.0	-0.5	1.0	-0.2
Bipolar Disorder or Schizophrenia	0.3	0.7	0.9	-0.9	0.7	-0.8
Neuroticism (Nagel 2018)	0.3	0.6	1.4	-0.0	-1.2	-0.8
Ulcerative Colitis (UC)	0.3	0.5	1.0	1.0	-0.6	0.5
Type 2 Diabetes (T2D) (2018)	0.3	0.6	0.8	0.6	-0.9	-0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	0.6	-0.2	0.8
Relative age voice broke	0.3	0.5	0.7	0.5	0.8	0.8
Supplements: Glucosamine	0.3	0.4	1.3	-1.1	-0.0	0.0
Sitting height	0.3	1.9	2.5	-1.3	-1.6	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.2	0.3	1.1	0.3
Depression (self-reported)	0.3	0.3	0.9	0.0	-0.9	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.4	-0.5	-1.1	-1.2
Standing height	0.3	2.7	5.0	-2.2	-1.2	-1.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	0.4	0.3	0.9
Medication: Paracetamol	0.3	0.5	0.8	0.6	-0.7	0.9
Headache pain in last month	0.3	0.6	1.2	-1.1	-0.4	-0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.3	-0.0	0.7	-1.1
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.8	-0.4	0.9	0.5
High blood pressure (siblings)	0.3	0.4	0.7	0.8	-0.4	0.6
Number of full brothers	0.3	0.4	0.8	-0.0	-0.6	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.8	-0.1	0.7	0.9
Medication: Omeprazole	0.3	0.4	0.8	0.9	0.1	0.5
Number of full sisters	0.3	0.3	0.9	-0.3	0.2	0.9
Commuting to job workplace: Walk	0.3	0.3	0.5	-0.2	-0.7	0.7
Hearing aid user	0.3	0.3	0.7	-0.2	-0.8	-0.4
Medication: Paracetamol	0.3	0.5	0.7	0.8	-0.7	0.6
Leg fat percentage (left)	0.3	1.0	2.1	0.9	0.1	1.4
Irritability	0.3	0.6	0.9	-0.4	-0.8	-0.9
Depression (Nagel 2018)	0.2	0.3	0.6	-0.4	-0.1	-0.8
Worry (Nagel 2018)	0.2	0.5	0.6	0.6	-0.8	0.7
Age at First Birth	0.2	0.2	0.7	-0.0	-0.1	-0.8
Crohns Disease (2012)	0.2	0.3	0.7	-0.3	-0.2	-0.8
HDL Cholesterol	0.2	0.4	1.1	0.3	0.1	1.0
Blood Eosinophil Count	0.2	1.6	4.2	-0.0	-2.0	-0.9
Heel T-Score	0.2	1.4	2.9	1.1	0.3	1.7
BMI	0.2	1.2	2.2	1.0	0.7	1.5
Respiratory disease	0.2	0.5	1.3	-1.2	0.3	-0.3
Lung FEV1/FVC ratio	0.2	1.2	1.8	1.4	1.3	0.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	-0.5	-0.0	-0.7
Diabetes (father)	0.2	0.2	0.6	-0.3	-0.8	0.2
Pack years adult smoking proportion	0.2	0.3	0.7	0.0	-0.9	-0.1
Leg fat-free mass (left)	0.2	0.9	2.4	-1.6	-0.4	0.1
Trunk fat percentage	0.2	0.8	2.0	0.3	-1.4	0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.7	-0.4	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	1.0	0.3	-1.0	0.7
Serious illness, injury or assault to yourself	0.2	0.3	0.5	-0.0	-0.6	-0.7
Impedance of leg (left)	0.2	1.0	1.8	1.3	-1.1	0.1
Leg predicted mass (left)	0.2	0.8	2.3	-1.5	-0.5	0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	0.1	0.4	0.7
Qualifications: None of the above	0.2	0.4	1.1	1.0	-0.1	0.5
Trunk fat-free mass	0.2	1.1	3.1	-1.8	0.1	-0.3
Worrier / anxious feelings	0.2	0.5	1.2	0.0	0.5	1.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.1	-0.5	-1.1	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	0.4	0.4	0.5
Prospective memory result	0.2	0.2	0.7	0.1	0.8	-0.2
Impedance of arm (left)	0.2	1.0	2.2	0.2	-1.5	-0.9
Trunk predicted mass	0.2	1.0	2.9	-1.7	0.0	-0.3
Tense / ‘highly strung’	0.2	0.4	0.7	-0.1	-0.7	0.8
Loud music exposure frequency	0.2	0.3	0.6	-0.1	-0.4	-0.8
Body fat percentage	0.2	0.7	1.2	0.5	-1.1	0.8
Wheeze or whistling in the chest in last year	0.2	0.4	1.1	-1.1	-0.4	0.1
Emphysema/chronic bronchitis	0.2	0.2	0.6	-0.1	-0.2	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.4	0.5	-0.5	-0.6
Whole body fat mass	0.2	0.7	1.8	-0.2	-1.4	0.5
Leg fat mass (right)	0.2	0.7	1.3	0.0	-1.1	0.9
Overall health rating	0.2	0.5	1.0	-0.5	-1.0	-0.1
Age at last live birth	0.2	0.3	0.7	-0.0	-0.4	-0.9
Family relationship satisfaction	0.2	0.3	0.5	-0.5	0.1	0.7
Average weekly red wine intake	0.2	0.3	0.5	-0.7	0.4	-0.2
Whole body water mass	0.2	0.9	2.8	-1.7	-0.2	-0.1
Commuting to job workplace: Public transport	0.2	0.2	0.5	0.7	0.3	0.1
Ever depressed for a whole week	0.2	0.3	0.4	-0.5	0.7	0.4
Pain experienced in last month	0.2	0.4	0.5	0.6	0.7	0.5
Impedance of whole body	0.2	0.9	2.0	0.8	-1.4	-0.5
Leg fat mass (left)	0.2	0.7	1.6	0.3	-0.6	1.3
Schizophrenia (2018)	0.1	0.2	0.4	-0.3	0.6	0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.4	0.4	0.3
Crohns Disease (2017)	0.1	0.2	0.6	0.0	0.2	-0.8
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	0.9	-0.3	0.2
Schizophrenia (2014)	0.1	0.3	0.5	-0.7	0.6	0.3
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	-0.2	0.2	-0.5
Height	0.1	1.3	2.4	-1.0	-1.5	-0.6
Neuroticism	0.1	0.4	1.0	0.1	-1.0	-0.2
Hair Pigment	0.1	2.6	6.9	-0.8	-2.6	-0.5
Sensitivity / hurt feelings	0.1	0.1	0.2	-0.0	-0.4	-0.2
Relative age of first facial hair	0.1	0.2	0.3	0.4	0.6	0.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.2	0.5	0.2
Medication: Co-codamol	0.1	0.2	0.5	0.7	-0.0	0.1
Body mass index (BMI)	0.1	0.2	0.6	-0.1	0.2	0.8
Trunk fat mass	0.1	0.6	1.6	-0.3	-1.3	0.4
Weight	0.1	0.5	1.2	-1.1	-0.5	0.2
Arm fat percentage (right)	0.1	0.4	0.9	0.2	-0.9	0.4
Hip circumference	0.1	0.2	0.3	-0.5	-0.5	0.4
Arm fat mass (right)	0.1	0.4	0.8	-0.2	-0.9	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.2	-0.1	0.6
Peak expiratory flow (PEF)	0.1	0.3	0.9	0.0	0.9	0.2
Pulse wave reflection index	0.1	0.1	0.2	-0.2	0.4	-0.2
Blood clot in the leg (DVT)	0.1	0.1	0.1	0.3	-0.4	-0.2
Leg fat percentage (right)	0.1	0.5	0.8	0.5	-0.8	0.9
Arm fat-free mass (right)	0.1	0.5	1.2	-1.1	0.2	0.4
Arm predicted mass (right)	0.1	0.5	1.4	-1.2	-0.0	0.3
Comparative height size at age 10	0.1	0.3	0.6	-0.7	-0.4	0.4
Knee pain experienced in last month	0.1	0.1	0.3	-0.3	-0.5	0.1
Whole body fat-free mass	0.1	0.8	2.3	-1.5	-0.1	0.0
Leg fat-free mass (right)	0.1	0.8	2.0	-1.4	0.1	0.5
Arm fat percentage (left)	0.1	0.3	0.5	0.1	-0.7	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	0.6	0.3	0.4
Leg predicted mass (right)	0.1	0.8	1.9	-1.4	0.1	0.6
Arm fat mass (left)	0.1	0.5	1.2	-0.4	-1.1	0.3
Mother’s age at death	0.1	0.1	0.3	0.3	-0.5	0.2
Basal metabolic rate	0.1	0.7	2.2	-1.5	-0.2	0.1
Arm fat-free mass (left)	0.1	0.5	1.3	-1.1	-0.2	0.3
Unable to work because of sickness or disability	0.1	0.1	0.1	-0.2	-0.3	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.5	0.1	0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.4	0.0	-0.0
Alcohol drinker status: Previous	0.1	0.1	0.3	0.1	-0.3	-0.6
Arm predicted mass (left)	0.1	0.6	1.6	-1.3	-0.3	-0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.4	0.9	0.4	0.9	0.1
Waist Hip Ratio (WHR)	0.0	0.1	0.3	-0.1	-0.3	-0.6
Lung FVC	0.0	0.2	0.6	-0.1	-0.8	-0.0
Tanning	0.0	0.2	0.6	-0.1	0.8	-0.0
Average weekly fortified wine intake	0.0	0.0	0.0	0.2	-0.1	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	-0.2	-0.1	0.1
Medication: Levothyroxine sodium	0.0	0.1	0.1	-0.2	-0.2	-0.3
Waist circumference	0.0	0.1	0.1	-0.4	0.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.2	-0.0	-0.5	0.0
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	0.1	-0.4	0.0
Guilty feelings	0.0	0.1	0.1	-0.3	0.1	-0.3
Illnesses of father: High blood pressure	0.0	0.0	0.1	0.0	-0.4	-0.1
Pack years of smoking	0.0	0.0	0.1	0.0	-0.3	-0.0

Hub : Genes

RPAP3

Models

Trait associations