Hub : Genes

RPAP3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0444	0.0228	0.0260	0.034	0.011	0.035	0.022	0.026	7.3e-06	8.1e-03	4.2e-06	2.3e-04	6.9e-05
2	NTR	Blood	0.0208	0.0089	0.0048	-0.001	0.003	0.000	0.003	-0.001	6.1e-01	3.6e-02	4.1e-01	2.3e-02	7.8e-01
3	YFS	Blood	0.1645	0.0280	0.0000	0.123	0.095	0.114	0.124	0.122	3.9e-38	1.5e-29	2.8e-35	3.0e-38	7.5e-38

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.0	1.6	3.5	-1.1	0.3	-1.9
Bipolar Disorder or Schizophrenia	0.3	0.7	0.9	-0.9	0.7	-0.8
Depressed Affect (Nagel 2018)	0.9	1.8	2.8	-1.1	-1.7	-1.2
Depression (Nagel 2018)	0.2	0.3	0.6	-0.4	-0.1	-0.8
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.7	-0.6	1.9	-1.2
Neuroticism (Nagel 2018)	0.3	0.6	1.4	-0.0	-1.2	-0.8
Schizophrenia (2018)	0.1	0.2	0.4	-0.3	0.6	0.4
Schizophrenia vs Biploar Disorder	0.4	0.6	1.0	-0.9	-1.0	-0.3
Worry (Nagel 2018)	0.2	0.5	0.6	0.6	-0.8	0.7
Alzheimer’s Disease (in mother)	2.0	2.4	7.0	0.0	2.6	0.2
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.4	0.4	0.3
Alzheimer’s Disease (including proxy)	1.4	2.1	6.0	-0.0	2.4	0.5
Crohns Disease (2017)	0.1	0.2	0.6	0.0	0.2	-0.8
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	0.9	-0.3	0.2
Ulcerative Colitis (UC)	0.3	0.5	1.0	1.0	-0.6	0.5
Major Depression (MDD)	1.5	1.8	4.7	-0.7	2.2	-0.4
Reaction Time	2.1	4.0	6.8	-2.6	0.1	-2.3
Verbal and Numeric Reasoning (VNR)	0.7	1.7	2.9	-0.2	1.7	-1.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.8	1.1	1.9	-1.4	-0.7	-0.9
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.2	0.2	0.7	-0.0	-0.1	-0.8
Bipolar Disorder (2011)	1.9	1.9	3.7	-1.9	-1.0	-1.0
Body Mass Index (BMI) (2010)	0.5	0.7	0.9	0.7	1.0	0.7
Coronary Artery Disease (CAD)	0.6	0.8	1.8	-0.4	-1.4	0.5
Crohns Disease (2012)	0.2	0.3	0.7	-0.3	-0.2	-0.8
Mean Putamen Volume	1.7	2.0	3.1	-1.7	1.8	-0.2
Fasting Glucose	1.4	1.7	2.7	1.6	1.5	0.1
HbA1C	1.3	1.5	1.8	-1.0	-1.3	-1.3
HDL Cholesterol	0.2	0.4	1.1	0.3	0.1	1.0
LDL Cholesterol	0.8	1.2	1.8	0.7	-1.3	-1.2
Lupus	0.6	0.8	1.5	1.2	0.7	0.7
Neuroticism (2016)	1.3	1.9	3.7	-1.0	-1.0	-1.9
Primary Biliary Cirrhosis	0.6	0.9	1.1	0.9	0.9	1.1
Rheumatoid Arthritis	0.8	1.2	2.0	-1.4	1.1	-0.5
Schizophrenia (2014)	0.1	0.3	0.5	-0.7	0.6	0.3
Triglycerides	0.4	0.7	1.6	-0.0	-1.3	-0.6
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	-0.2	0.2	-0.5
Ulcerative Colitis	1.4	2.1	2.8	1.7	-0.9	1.6
Blood Eosinophil Count	0.2	1.6	4.2	-0.0	-2.0	-0.9
Blood Platelet Count	2.7	31.7	94.9	-0.0	-9.7	0.6
Blood Red Count	3.7	35.4	71.7	3.0	8.5	5.0
Blood White Count	0.0	0.4	0.9	0.4	0.9	0.1
Heel T-Score	0.2	1.4	2.9	1.1	0.3	1.7
BMI	0.2	1.2	2.2	1.0	0.7	1.5
Height	0.1	1.3	2.4	-1.0	-1.5	-0.6
Waist Hip Ratio (WHR)	0.0	0.1	0.3	-0.1	-0.3	-0.6
Systolic Blood Pressure	0.9	4.7	5.8	2.4	-1.8	2.3
Smoking Status	1.0	2.4	5.1	-1.2	-0.9	-2.3
Allergy or Eczema	1.7	4.5	7.0	2.6	1.8	1.9
Cardiovascular Disease	3.1	10.2	14.9	3.9	-1.7	3.6
Hypothyroidism (self reported)	0.7	1.6	3.3	-0.4	1.8	-1.1
Respiratory disease	0.2	0.5	1.3	-1.2	0.3	-0.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	0.8	0.6	-0.9	-0.7
Lung FEV1/FVC ratio	0.2	1.2	1.8	1.4	1.3	0.4
Lung FVC	0.0	0.2	0.6	-0.1	-0.8	-0.0
Neuroticism	0.1	0.4	1.0	0.1	-1.0	-0.2
Chronotype (morning person)	0.8	1.9	3.9	1.0	-2.0	0.9
Hair Pigment	0.1	2.6	6.9	-0.8	-2.6	-0.5
Tanning	0.0	0.2	0.6	-0.1	0.8	-0.0
Hand grip strength (left)	1.2	3.2	9.2	-0.4	3.0	0.5
Number of treatments/medications taken	0.7	1.2	3.6	0.2	-1.9	-0.2
Average weekly spirits intake	1.4	1.8	3.0	1.7	-1.4	-0.7
Sensitivity / hurt feelings	0.1	0.1	0.2	-0.0	-0.4	-0.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	-0.5	-0.0	-0.7
Hearing difficulty/problems: Yes	0.4	0.6	1.3	-0.3	-0.6	-1.1
Relative age of first facial hair	0.1	0.2	0.3	0.4	0.6	0.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.2	0.5	0.2
Ever used hormone-replacement therapy (HRT)	2.0	2.5	4.4	2.1	-0.5	1.7
Ever had hysterectomy (womb removed)	0.4	0.4	1.3	-1.1	0.2	0.0
Systolic blood pressure, automated reading	1.7	4.9	7.7	2.8	0.5	2.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	0.6	-0.2	0.8
Angina	1.7	2.2	5.9	0.3	-2.4	-0.8
Medication for hormone replacement therapy	2.4	2.7	6.8	1.0	-2.6	0.5
Vitamin and mineral supplements	0.7	0.9	1.3	1.2	0.5	1.0
Supplements: Zinc	1.0	1.1	2.2	-1.0	-1.5	0.3
Medication: Co-codamol	0.1	0.2	0.5	0.7	-0.0	0.1
Medication: Metformin	0.6	0.8	1.4	1.2	-0.9	0.5
Diabetes (father)	0.2	0.2	0.6	-0.3	-0.8	0.2
Diabetes (mother)	3.5	4.5	8.1	2.8	-0.3	2.3
Severe depression (siblings)	0.8	0.8	1.9	0.1	-0.8	1.4
Pack years adult smoking proportion	0.2	0.3	0.7	0.0	-0.9	-0.1
Impedance of leg (right)	0.5	2.3	5.4	0.9	-2.3	-0.8
Leg fat-free mass (left)	0.2	0.9	2.4	-1.6	-0.4	0.1
Trunk fat percentage	0.2	0.8	2.0	0.3	-1.4	0.6
Hand grip strength (right)	1.1	3.0	8.1	-0.0	2.9	1.0
Townsend deprivation index at recruitment	1.4	1.9	3.1	1.2	-1.8	1.1
Current tobacco smoking	0.6	1.0	2.0	-0.7	0.7	-1.4
Average weekly fortified wine intake	0.0	0.0	0.0	0.2	-0.1	0.1
Maternal smoking around birth	1.2	1.8	3.7	1.9	-0.8	1.0
Fed-up feelings	1.7	3.1	5.6	-1.8	-2.4	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	-0.2	-0.1	0.1
Relative age voice broke	0.3	0.5	0.7	0.5	0.8	0.8
Taking other prescription medications	0.9	1.3	4.0	0.1	-2.0	0.2
Age when periods started (menarche)	0.8	1.9	3.6	-1.1	-1.9	-0.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.7	-0.4	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	1.0	0.3	-1.0	0.7
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	3.4	1.8	0.4	1.8
Qualifications: CSEs or equivalent	0.6	0.8	1.7	0.9	-1.3	0.3
Serious illness, injury or assault to yourself	0.2	0.3	0.5	-0.0	-0.6	-0.7
High blood pressure	3.3	9.2	16.1	3.3	-0.6	4.0
Hayfever, allergic rhinitis or eczema	1.5	3.3	4.9	2.2	1.7	1.4
Multivitamins +/- minerals	1.6	2.0	3.9	-2.0	-0.3	-1.4
Stomach or abdominal pain in last month	1.1	1.4	2.7	1.6	0.7	1.0
Supplements: Glucosamine	0.3	0.4	1.3	-1.1	-0.0	0.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.0	-0.2	-1.4	-0.2
Medication: Atenolol	1.2	1.5	3.9	-0.7	-2.0	-0.4
Medication: Levothyroxine sodium	0.0	0.1	0.1	-0.2	-0.2	-0.3
Sitting height	0.3	1.9	2.5	-1.3	-1.6	-1.2
Chronic bronchitis/emphysema (father)	1.3	1.5	2.9	-1.7	1.3	-0.1
High blood pressure (mother)	2.3	3.3	9.3	0.7	-3.0	-0.2
Body mass index (BMI)	0.1	0.2	0.6	-0.1	0.2	0.8
Impedance of leg (left)	0.2	1.0	1.8	1.3	-1.1	0.1
Leg predicted mass (left)	0.2	0.8	2.3	-1.5	-0.5	0.2
Trunk fat mass	0.1	0.6	1.6	-0.3	-1.3	0.4
Waist circumference	0.0	0.1	0.1	-0.4	0.1	0.3
Number of incorrect matches in round	0.8	1.3	1.9	-1.4	0.9	-1.2
Past tobacco smoking	1.2	2.1	4.3	1.1	0.9	2.1
Alcohol usually taken with meals	1.3	2.1	4.7	-1.1	2.2	-0.5
Nervous feelings	0.6	1.1	1.5	-0.9	-1.1	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.2	0.3	1.1	0.3
Hearing difficulty/problems with background noise	0.5	0.8	1.8	-0.8	-1.3	-0.2
Hair/balding pattern: Pattern 2	1.5	1.9	3.1	1.8	1.2	1.0
Had menopause	1.8	2.3	4.7	2.2	-0.2	1.4
Had other major operations	0.4	0.5	1.2	-0.4	-1.1	-0.1
Forced vital capacity (FVC)	0.4	1.5	1.6	-1.2	-1.2	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.3	0.8	-2.1	0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	0.1	0.4	0.7
Qualifications: None of the above	0.2	0.4	1.1	1.0	-0.1	0.5
Financial difficulties in last 2 years	1.2	1.6	2.8	0.3	-1.3	1.7
Mouth/teeth dental problems	1.2	1.8	3.5	-1.0	-1.9	-0.9
Heart attack	0.9	1.2	1.8	1.2	-1.4	-0.3
Allergy	0.5	1.3	2.2	-0.9	-1.5	-0.9
Pain all over the body in last month	0.5	0.6	1.7	-0.2	-1.3	0.1
Diabetes (self-reported)	0.5	0.7	1.7	1.3	-0.6	0.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	1.6	1.3	1.1	1.1
Medication: Ramipril	1.0	1.3	2.3	0.7	-1.5	1.0
Medication: Simvastatin	3.4	5.1	13.2	1.4	-3.6	-0.0
Fluid intelligence score	0.4	0.9	2.3	0.2	1.5	-0.6
Illnesses of siblings	1.3	1.8	3.8	-1.1	1.9	-0.7
Neuroticism score	0.7	1.6	3.1	-1.0	-1.8	-0.8
Weight	0.1	0.5	1.2	-1.1	-0.5	0.2
Impedance of arm (right)	0.5	2.3	5.2	0.2	-2.3	-1.3
Arm fat percentage (right)	0.1	0.4	0.9	0.2	-0.9	0.4
Trunk fat-free mass	0.2	1.1	3.1	-1.8	0.1	-0.3
Hip circumference	0.1	0.2	0.3	-0.5	-0.5	0.4
Time employed in main current job	1.1	1.2	1.4	1.1	-1.2	1.1
Alcohol intake versus 10 years previously	3.7	5.5	5.8	2.4	-2.3	2.4
Father’s age at death	0.8	1.0	2.6	-1.6	-0.4	-0.5
Worrier / anxious feelings	0.2	0.5	1.2	0.0	0.5	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.2	-0.0	-0.5	0.0
Falls in the last year	0.5	0.7	1.9	-0.3	0.3	-1.4
Hair/balding pattern: Pattern 3	1.7	2.5	5.7	-2.4	-0.1	-1.4
Number of live births	0.5	0.7	1.9	-0.3	1.4	0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.1	-0.5	-1.1	-0.8
Pulse rate	0.5	0.9	2.0	-0.0	1.4	0.8
Happiness	0.9	1.0	2.7	-1.6	-0.5	-0.4
Noisy workplace	1.6	2.0	4.9	2.2	-0.4	1.0
Qualifications: A levels/AS levels or equivalent	2.1	4.6	7.7	-2.5	-0.0	-2.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	0.4	0.4	0.5
Mouth/teeth dental problems: Dentures	1.7	2.8	4.9	1.6	2.2	1.0
Asthma	0.6	1.3	2.8	-1.7	0.1	-1.0
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	5.1	-0.7	-2.3	-1.0
Medication: Cholesterol lowering	2.9	4.5	8.9	2.1	-3.0	0.2
Depression (self-reported)	0.3	0.3	0.9	0.0	-0.9	-0.3
Medication: Lansoprazole	1.6	1.9	3.5	1.9	-0.3	1.4
Prospective memory result	0.2	0.2	0.7	0.1	0.8	-0.2
Lung cancer (father)	1.3	1.6	4.5	-0.1	-2.1	-0.4
Illnesses of mother	0.6	0.7	1.7	-0.4	1.3	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.4	-0.5	-1.1	-1.2
Pulse wave Arterial Stiffness index	1.1	1.2	1.6	0.9	1.1	1.3
Impedance of arm (left)	0.2	1.0	2.2	0.2	-1.5	-0.9
Arm fat mass (right)	0.1	0.4	0.8	-0.2	-0.9	0.5
Trunk predicted mass	0.2	1.0	2.9	-1.7	0.0	-0.3
Standing height	0.3	2.7	5.0	-2.2	-1.2	-1.3
Length of working week for main job	1.4	1.6	2.4	-1.5	-1.1	-1.1
Exposure to tobacco smoke at home	5.1	5.7	8.9	-3.0	-0.2	-2.9
Breastfed as a baby	0.6	0.8	1.6	1.3	0.0	0.8
Tense / ‘highly strung’	0.2	0.4	0.7	-0.1	-0.7	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.2	-0.1	0.6
Hair/balding pattern: Pattern 4	0.5	1.1	2.0	1.4	-1.0	0.7
Birth weight of first child	0.5	1.0	1.9	0.9	0.4	1.4
Peak expiratory flow (PEF)	0.1	0.3	0.9	0.0	0.9	0.2
Pulse wave reflection index	0.1	0.1	0.2	-0.2	0.4	-0.2
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.0	0.9	0.0	1.7
Loud music exposure frequency	0.2	0.3	0.6	-0.1	-0.4	-0.8
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	6.7	-2.6	0.1	-1.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	0.4	0.3	0.9
Blood clot in the leg (DVT)	0.1	0.1	0.1	0.3	-0.4	-0.2
Medication: Paracetamol	0.3	0.5	0.8	0.6	-0.7	0.9
Headache pain in last month	0.3	0.6	1.2	-1.1	-0.4	-0.6
Medication for cholesterol, blood pressure or diabetes	2.4	4.0	6.5	-2.1	2.6	-0.9
Glaucoma (self-reported)	0.5	0.6	1.1	-1.0	-0.4	-0.8
Gout (self-reported)	3.4	4.7	6.6	2.0	-1.8	2.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.3	-0.0	0.7	-1.1
Medication: Amlodipine	1.3	1.8	3.7	0.8	-1.9	1.0
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.7	0.5	-0.7	1.7
Birth weight	0.5	1.2	3.1	0.7	0.2	1.8
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.8	-0.4	0.9	0.5
High blood pressure (siblings)	0.3	0.4	0.7	0.8	-0.4	0.6
Forced vital capacity (FVC), Best measure	0.5	1.6	1.9	-1.3	-1.2	-1.4
Body fat percentage	0.2	0.7	1.2	0.5	-1.1	0.8
Leg fat percentage (right)	0.1	0.5	0.8	0.5	-0.8	0.9
Arm fat-free mass (right)	0.1	0.5	1.2	-1.1	0.2	0.4
Exposure to tobacco smoke outside home	0.4	0.5	0.8	-0.9	-0.2	-0.9
Comparative body size at age 10	0.5	1.4	3.5	-1.9	-0.6	-0.5
Number of full brothers	0.3	0.4	0.8	-0.0	-0.6	-0.9
Worry too long after embarrassment	0.8	1.4	3.7	-0.2	-1.9	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.8	-0.1	0.7	0.9
Wheeze or whistling in the chest in last year	0.2	0.4	1.1	-1.1	-0.4	0.1
Number of children fathered	0.6	0.6	1.5	1.2	0.6	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.0	-1.4	0.5	-1.2
Age at first live birth	0.8	1.5	2.2	-0.4	-1.5	-1.5
Pulse wave peak to peak time	1.1	1.4	1.7	-0.9	-1.3	-1.2
Health satisfaction	0.7	0.9	2.2	1.5	0.3	0.5
Shortness of breath walking on level ground	0.6	0.7	0.9	1.0	0.8	0.6
Qualifications: College or University degree	0.6	1.8	3.1	-0.8	1.3	-1.8
Eye problems/disorders: None of the above	2.5	2.9	7.8	0.6	-2.8	0.6
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.0	1.4	0.2	1.3
Emphysema/chronic bronchitis	0.2	0.2	0.6	-0.1	-0.2	0.8
Medication for pain relief, constipation, heartburn	1.0	1.8	4.5	0.0	2.1	0.9
Neck or shoulder pain in last month	0.7	1.0	2.7	-0.1	-1.6	-0.6
Medication: Blood pressure	2.3	4.1	8.2	1.7	-2.9	1.1
Angina (self-reported)	1.8	2.4	6.4	0.4	-2.5	-0.8
Migraine (self-reported)	0.7	0.9	1.4	1.1	-0.2	1.2
Medication: Ibuprofen	1.2	1.4	2.5	-0.8	-1.6	-1.0
Medication: Allopurinol	3.6	4.8	5.7	2.3	-1.8	2.4
Medication: Omeprazole	0.3	0.4	0.8	0.9	0.1	0.5
Medication: Seretide 50 evohaler	0.6	0.7	1.1	1.1	0.7	0.7
Mean time to correctly identify matches	0.8	1.4	2.1	-1.5	1.0	-1.1
Heart disease (mother)	1.7	2.1	4.9	0.5	-2.2	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.4	0.5	-0.5	-0.6
Whole body fat mass	0.2	0.7	1.8	-0.2	-1.4	0.5
Leg fat mass (right)	0.2	0.7	1.3	0.0	-1.1	0.9
Arm predicted mass (right)	0.1	0.5	1.4	-1.2	-0.0	0.3
Pulse rate, automated reading	0.7	2.2	2.9	1.7	1.0	1.6
Alcohol intake frequency.	0.4	1.0	2.2	0.8	-0.2	1.5
Comparative height size at age 10	0.1	0.3	0.6	-0.7	-0.4	0.4
Number of full sisters	0.3	0.3	0.9	-0.3	0.2	0.9
Suffer from ‘nerves’	1.4	2.2	5.4	-0.9	-2.3	-0.7
Overall health rating	0.2	0.5	1.0	-0.5	-1.0	-0.1
Chest pain or discomfort	2.1	3.0	5.5	1.7	-0.9	2.3
Had major operations	2.0	2.3	4.8	-1.3	-0.8	-2.2
Age at last live birth	0.2	0.3	0.7	-0.0	-0.4	-0.9
Family relationship satisfaction	0.2	0.3	0.5	-0.5	0.1	0.7
Leg pain on walking	1.0	1.3	2.1	1.5	-1.0	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.3	-0.8	-1.1	0.7
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.1	-0.7	0.5	-1.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.0	3.0	1.7	-0.2	0.3
Medication: Aspirin	3.3	4.4	12.9	0.2	-3.6	-0.5
Supplements: Vitamin C	0.6	0.7	1.5	-0.4	1.2	0.7
Knee pain experienced in last month	0.1	0.1	0.3	-0.3	-0.5	0.1
Hypertension (Self-reported)	2.8	7.7	13.3	3.1	-0.6	3.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.3	0.5	1.5	0.5
Illnesses of father: Heart disease	0.4	0.6	1.2	0.5	0.6	1.1
Illnesses of siblings: Diabetes	0.4	0.5	0.9	0.0	-0.9	0.9
Smoking status: Previous	1.4	2.0	2.4	-1.5	-1.3	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.2	-1.1	-0.9	-0.8
Whole body fat-free mass	0.1	0.8	2.3	-1.5	-0.1	0.0
Leg fat-free mass (right)	0.1	0.8	2.0	-1.4	0.1	0.5
Arm fat percentage (left)	0.1	0.3	0.5	0.1	-0.7	0.6
Average weekly red wine intake	0.2	0.3	0.5	-0.7	0.4	-0.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.0	-0.9	1.0	0.1
Mood swings	0.8	1.5	4.4	-0.2	-2.1	-0.1
Loneliness, isolation	0.4	0.6	1.3	-1.2	-0.5	-0.5
Long-standing illness, disability or infirmity	1.2	1.9	5.2	0.7	-2.3	-0.2
Ever had bowel cancer screening	0.5	0.6	1.0	-0.8	-1.0	-0.2
Diabetes diagnosed by doctor	0.5	0.9	1.8	1.3	-0.8	0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.7	-1.2	1.6	-0.4
Friendships satisfaction	1.2	1.4	2.1	0.8	-1.4	1.2
Qualifications: nursing, teaching	2.5	3.9	4.8	-2.2	-1.5	-2.2
Commuting to job workplace: Walk	0.3	0.3	0.5	-0.2	-0.7	0.7
Eye problems/disorders: Cataract	0.9	1.1	2.9	-0.4	1.7	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	0.1	-0.4	0.0
Medication for cholesterol	2.6	4.0	10.7	-1.0	3.3	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	5.8	2.4	-0.5	1.0
Back pain experienced in last month	1.6	2.4	3.6	-1.9	-0.5	-1.8
Mineral and other dietary supplements	2.4	3.2	6.9	2.6	0.8	1.5
Breast cancer (self-reported)	1.3	1.5	3.3	-1.8	-0.6	-0.9
Asthma (self-reported)	0.7	1.3	3.0	-1.7	0.2	-1.0
Osteoporosis (self-reported)	1.0	1.3	2.3	-1.2	-0.1	-1.5
Osteoarthritis (self-reported)	0.6	0.8	1.2	1.1	-0.0	1.1
Medication: Aspirin	2.9	3.8	10.0	-0.7	-3.2	-1.0
Medication: Gliclazide	1.3	1.5	2.3	1.5	-1.0	1.1
Illnesses of father: None of the above (group 1)	0.8	0.9	1.9	-0.8	-0.5	-1.4
Smoking status: Current	0.7	1.1	2.0	-0.6	0.9	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	0.6	0.3	0.4
Whole body water mass	0.2	0.9	2.8	-1.7	-0.2	-0.1
Leg predicted mass (right)	0.1	0.8	1.9	-1.4	0.1	0.6
Arm fat mass (left)	0.1	0.5	1.2	-0.4	-1.1	0.3
Number of self-reported non-cancer illnesses	1.7	2.9	4.2	2.0	-1.6	1.3
Average weekly champagne plus white wine intake	1.8	2.5	4.7	-1.3	1.1	-2.2
Miserableness	2.9	5.0	5.5	-2.3	-2.1	-2.4
Guilty feelings	0.0	0.1	0.1	-0.3	0.1	-0.3
Wears glasses or contact lenses	0.6	0.7	1.5	1.2	0.2	0.7
Ever taken oral contraceptive pill	2.8	3.1	7.6	-1.3	-0.1	-2.8
Hearing aid user	0.3	0.3	0.7	-0.2	-0.8	-0.4
Mother’s age at death	0.1	0.1	0.3	0.3	-0.5	0.2
Financial situation satisfaction	0.8	1.0	2.1	1.5	-0.9	0.3
Tinnitus: Yes, now most or all of the time	2.9	3.4	4.4	-2.1	1.7	-1.6
Commuting to job workplace: Public transport	0.2	0.2	0.5	0.7	0.3	0.1
Eye problems/disorders: Glaucoma	0.7	0.8	1.3	-1.0	1.1	-0.4
Medication: Blood pressure	0.9	1.7	2.6	0.6	-1.4	1.6
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.8	1.1	-0.0	1.3
Supplements: Fish oil (including cod liver oil)	2.2	2.8	5.6	-2.4	-0.2	-1.7
High cholesterol (Self-reported)	1.7	3.0	4.9	1.9	-2.2	-0.8
Medication: Bendroflumethiazide	2.1	3.2	4.6	-2.0	-2.1	-1.1
Medication: Paracetamol	0.3	0.5	0.7	0.8	-0.7	0.6
Medication: Lisinopril	2.3	3.0	3.6	1.4	-1.9	1.9
Medication: Atorvastatin	0.7	0.8	1.8	0.5	-0.7	-1.3
Illnesses of father: High blood pressure	0.0	0.0	0.1	0.0	-0.4	-0.1
Alcohol drinker status: Never	0.4	0.4	1.0	-0.5	1.0	-0.2
Ever smoked	0.8	1.4	3.2	-0.3	-1.0	-1.8
Basal metabolic rate	0.1	0.7	2.2	-1.5	-0.2	0.1
Leg fat percentage (left)	0.3	1.0	2.1	0.9	0.1	1.4
Arm fat-free mass (left)	0.1	0.5	1.3	-1.1	-0.2	0.3
Number of operations (self-reported)	1.7	2.5	6.9	-0.2	-2.6	-0.8
Average weekly beer plus cider intake	2.2	3.2	5.1	2.1	-0.3	2.3
Irritability	0.3	0.6	0.9	-0.4	-0.8	-0.9
Risk taking	0.5	0.7	1.5	-0.6	-1.2	-0.5
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.7	-1.3	0.5	-0.9
Fractured/broken bones in last 5 years	2.0	2.6	3.8	-1.9	-0.5	-1.9
Age started oral contraceptive pill	0.9	1.1	1.5	1.2	-0.6	1.2
Diastolic blood pressure, automated reading	2.0	6.1	10.5	2.0	2.0	3.2
Ever depressed for a whole week	0.2	0.3	0.4	-0.5	0.7	0.4
Unable to work because of sickness or disability	0.1	0.1	0.1	-0.2	-0.3	-0.2
Commuting to job workplace: Cycle	0.9	1.1	2.0	0.5	-1.0	1.4
Myopia	4.4	6.3	8.2	-2.3	-2.9	-2.4
Vascular/heart problems diagnosed by doctor	4.0	10.8	18.2	-3.6	1.2	-4.3
Cholesterol lowering medication	0.9	1.3	2.2	1.2	-1.5	0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.5	0.1	0.5
Pain experienced in last month	0.2	0.4	0.5	0.6	0.7	0.5
Supplements: Calcium	2.2	2.4	3.4	-1.5	-1.8	-1.2
Basal cell carcinoma (self-reported)	1.5	1.7	2.0	-1.4	-1.3	-1.2
Heart attack/myocardial infarction (self-reported)	0.9	1.1	1.9	1.4	-1.2	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.4	0.0	-0.0
Heart disease (siblings)	1.2	1.4	2.9	1.2	-1.7	-0.2
Alcohol drinker status: Previous	0.1	0.1	0.3	0.1	-0.3	-0.6
Pack years of smoking	0.0	0.0	0.1	0.0	-0.3	-0.0
Impedance of whole body	0.2	0.9	2.0	0.8	-1.4	-0.5
Leg fat mass (left)	0.2	0.7	1.6	0.3	-0.6	1.3
Arm predicted mass (left)	0.1	0.6	1.6	-1.3	-0.3	-0.0