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chr12:52,990,150-55,391,259

Best TWAS P=9.34e-42 · Best GWAS P=6.7e-42 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
38	GTEx	Esophagus Muscularis	SP1	0.15	0.22	lasso	3	0.21	5.9e-13	13.56	13.5	9.3e-42	1.00	0.00	1.00	TRUE
5	GTEx	Adipose Visceral Omentum	PRR13	0.09	0.09	lasso	2	0.06	4.2e-04	11.40	-11.2	3.8e-29	-0.86	0.11	0.66	TRUE
43	GTEx	Lung	SP1	0.17	0.04	enet	33	0.08	1.3e-06	11.40	8.6	9.2e-18	0.74	0.03	0.97	TRUE
67	YFS	Blood	NFE2	0.02	0.02	bslmm	400	0.09	1.6e-28	5.89	8.2	2.0e-16	-0.01	0.30	0.65	TRUE
26	GTEx	Cells Transformed fibroblasts	PFDN5	0.19	0.14	lasso	5	0.16	7.8e-12	-7.10	-7.6	3.2e-14	-0.37	1.00	0.00	TRUE
80	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ESPL1	0.10	0.12	blup	43	0.13	1.6e-06	-6.89	5.4	6.8e-08	0.16	0.10	0.90	TRUE
68	YFS	Blood	SP1	0.22	0.17	bslmm	398	0.18	1.4e-56	13.51	13.5	2.2e-41	0.95	0.00	1.00	FALSE
65	METSIM	Adipose	PRR13	0.08	0.06	bslmm	395	0.06	3.0e-09	12.73	-13.2	8.2e-40	-0.94	0.02	0.98	FALSE
44	GTEx	Lung	PRR13	0.06	0.06	lasso	2	0.03	1.6e-03	13.10	-13.1	4.5e-39	-0.99	0.02	0.97	FALSE
27	GTEx	Cells Transformed fibroblasts	SP1	0.07	0.04	lasso	5	0.03	1.2e-03	12.71	12.9	3.3e-38	0.98	0.02	0.97	FALSE
25	GTEx	Breast Mammary Tissue	SP1	0.12	0.13	lasso	5	0.08	9.5e-05	12.55	12.9	6.4e-38	0.93	0.02	0.98	FALSE
11	GTEx	Artery Coronary	SP1	0.17	0.12	lasso	4	0.12	8.6e-05	13.56	12.8	1.9e-37	0.93	0.01	0.98	FALSE
6	GTEx	Adrenal Gland	SP1	0.27	0.35	lasso	3	0.34	4.4e-13	12.55	12.8	2.6e-37	0.97	0.01	0.99	FALSE
85	The Cancer Genome Atlas	Thyroid Carcinoma	PRR13	0.11	0.14	blup	28	0.15	2.9e-14	12.72	-12.7	6.4e-37	-0.95	0.03	0.97	FALSE
58	GTEx	Testis	PRR13	0.21	0.19	lasso	2	0.18	2.9e-08	12.61	-12.7	1.0e-36	-0.93	0.04	0.96	FALSE
9	GTEx	Artery Aorta	SP1	0.14	0.14	lasso	8	0.14	2.2e-08	13.51	12.6	1.7e-36	0.97	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	SP1	0.09	0.13	lasso	3	0.11	4.1e-09	12.55	12.6	2.5e-36	0.96	0.58	0.42	FALSE
71	The Cancer Genome Atlas	Breast Invasive Carcinoma	PRR13	0.01	0.02	lasso	5	0.01	1.2e-03	12.58	-12.6	2.9e-36	-0.95	0.01	0.94	FALSE
30	GTEx	Colon Transverse	SP1	0.10	0.09	lasso	1	0.06	7.7e-04	12.55	12.6	3.9e-36	0.96	0.01	0.99	FALSE
35	GTEx	Esophagus Mucosa	SP1	0.35	0.46	lasso	3	0.45	2.6e-33	12.55	12.4	2.5e-35	0.96	0.56	0.44	FALSE
63	GTEx	Vagina	SP1	0.36	0.12	lasso	12	0.16	1.3e-04	12.58	12.4	4.0e-35	0.87	0.02	0.94	FALSE
36	GTEx	Esophagus Mucosa	PRR13	0.08	0.05	lasso	4	0.04	8.3e-04	12.61	-12.3	1.6e-34	-0.92	0.03	0.87	FALSE
48	GTEx	Nerve Tibial	PRR13	0.17	0.21	lasso	3	0.20	2.7e-14	11.82	-12.1	8.6e-34	-0.90	0.36	0.64	FALSE
66	METSIM	Adipose	SP1	0.09	0.09	bslmm	405	0.08	5.0e-12	12.50	12.0	2.7e-33	0.91	0.54	0.46	FALSE
61	GTEx	Thyroid	PRR13	0.22	0.18	lasso	9	0.24	4.8e-18	12.61	-11.9	7.3e-33	-0.93	0.08	0.92	FALSE
74	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PRR13	0.03	0.03	blup	28	0.04	4.6e-05	12.61	-11.7	9.9e-32	-0.93	0.01	0.98	FALSE
79	The Cancer Genome Atlas	Brain Lower Grade Glioma	SP1	0.03	0.01	lasso	2	0.02	1.1e-03	13.25	11.5	1.1e-30	0.92	0.01	0.85	FALSE
39	GTEx	Esophagus Muscularis	PRR13	0.13	0.15	lasso	2	0.14	9.2e-09	11.82	-11.5	1.3e-30	-0.87	0.42	0.58	FALSE
3	GTEx	Adipose Subcutaneous	PRR13	0.13	0.10	lasso	7	0.09	9.2e-08	11.82	-11.4	5.4e-30	-0.88	0.01	0.99	FALSE
53	GTEx	Skin Sun Exposed Lower leg	SP1	0.13	0.10	lasso	3	0.13	1.1e-10	12.50	11.2	4.2e-29	0.90	0.71	0.29	FALSE
47	GTEx	Nerve Tibial	SP1	0.27	0.31	enet	29	0.31	1.7e-22	12.55	11.1	8.6e-29	0.89	0.92	0.08	FALSE
31	GTEx	Colon Transverse	PRR13	0.13	0.01	enet	15	0.01	1.0e-01	11.82	-11.0	3.0e-28	-0.82	0.04	0.80	FALSE
76	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PRR13	0.08	0.05	blup	28	0.07	6.3e-08	12.58	-11.0	5.9e-28	-0.84	0.04	0.96	FALSE
17	GTEx	Brain Cerebellum	PRR13	0.19	0.02	enet	5	0.03	4.6e-02	10.34	10.8	3.9e-27	0.85	0.04	0.74	FALSE
52	GTEx	Skin Not Sun Exposed Suprapubic	PRR13	0.17	0.09	lasso	4	0.09	1.6e-05	11.40	-10.6	2.3e-26	-0.86	0.22	0.77	FALSE
60	GTEx	Thyroid	SP1	0.11	0.05	lasso	7	0.04	8.2e-04	10.20	10.6	3.6e-26	0.86	0.05	0.93	FALSE
77	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PRR13	0.05	0.03	blup	28	0.04	4.1e-03	11.82	-10.3	4.8e-25	-0.85	0.02	0.42	FALSE
28	GTEx	Cells Transformed fibroblasts	RP11-680A11.5	0.10	0.03	lasso	4	0.03	1.3e-03	9.60	-10.2	1.5e-24	-0.74	0.02	0.94	FALSE
51	GTEx	Skin Not Sun Exposed Suprapubic	SP1	0.08	0.02	enet	7	0.05	1.6e-03	12.50	10.1	9.0e-24	0.76	0.03	0.92	FALSE
23	GTEx	Brain Putamen basal ganglia	RP11-793H13.11	0.29	0.05	lasso	7	0.05	2.6e-02	11.82	-9.9	4.4e-23	-0.72	0.03	0.55	FALSE
33	GTEx	Esophagus Gastroesophageal Junction	PRR13	0.22	0.16	lasso	4	0.18	3.2e-07	11.82	-9.8	7.9e-23	-0.81	0.14	0.53	FALSE
54	GTEx	Skin Sun Exposed Lower leg	PRR13	0.22	0.08	lasso	5	0.17	6.5e-14	11.40	-9.7	2.4e-22	-0.81	0.02	0.98	FALSE
32	GTEx	Esophagus Gastroesophageal Junction	ATP5G2	0.14	0.01	lasso	5	0.02	5.0e-02	8.23	9.7	3.4e-22	0.80	0.09	0.62	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	PRR13	0.07	0.04	blup	28	0.05	4.7e-06	11.82	-9.6	9.9e-22	-0.79	0.05	0.90	FALSE
10	GTEx	Artery Aorta	PRR13	0.23	0.28	enet	39	0.30	4.3e-17	11.82	-9.3	2.2e-20	-0.76	0.19	0.81	FALSE
13	GTEx	Artery Tibial	PRR13	0.15	0.18	enet	21	0.22	5.4e-17	11.82	-9.2	2.7e-20	-0.76	0.54	0.46	FALSE
45	GTEx	Muscle Skeletal	RP11-793H13.11	0.07	0.04	lasso	3	0.06	1.2e-06	-7.27	-9.2	5.0e-20	-0.59	0.34	0.63	FALSE
12	GTEx	Artery Coronary	PRR13	0.20	0.10	lasso	4	0.09	6.8e-04	9.35	-9.0	1.5e-19	-0.77	0.03	0.80	FALSE
1	GTEx	Adipose Subcutaneous	ATP5G2	0.06	0.02	lasso	3	0.02	1.1e-02	8.77	8.4	6.7e-17	0.67	0.28	0.12	FALSE
70	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PRR13	0.13	0.04	blup	28	0.07	3.3e-06	13.25	-8.2	2.6e-16	-0.74	0.01	0.90	FALSE
18	GTEx	Brain Cortex	ATP5G2	0.37	0.38	enet	28	0.37	4.3e-11	5.81	8.1	3.8e-16	0.64	0.75	0.24	FALSE
24	GTEx	Breast Mammary Tissue	ATP5G2	0.13	0.17	enet	17	0.13	3.3e-07	5.81	8.0	8.4e-16	0.58	0.48	0.51	FALSE
64	METSIM	Adipose	ATP5G2	0.07	0.02	lasso	8	0.03	9.5e-05	5.83	8.0	1.1e-15	0.65	0.87	0.03	FALSE
40	GTEx	Heart Left Ventricle	RP11-793H13.11	0.12	0.00	enet	17	0.05	1.6e-03	6.00	-8.0	1.4e-15	-0.49	0.27	0.06	FALSE
55	GTEx	Skin Sun Exposed Lower leg	RP11-793H13.11	0.05	0.03	lasso	6	0.02	6.1e-03	-6.73	-7.8	7.8e-15	-0.36	0.59	0.13	FALSE
83	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ATP5G2	0.21	0.04	enet	11	0.09	1.5e-04	8.08	-7.2	6.4e-13	-0.65	0.01	0.93	FALSE
75	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ESPL1	0.05	0.08	lasso	2	0.07	5.5e-08	-7.08	7.1	1.7e-12	0.32	0.37	0.63	FALSE
84	The Cancer Genome Atlas	Rectum Adenocarcinoma	PCBP2	0.25	0.04	blup	36	0.10	2.3e-03	0.29	-7.0	3.5e-12	-0.65	0.01	0.12	FALSE
14	GTEx	Brain Caudate basal ganglia	ATP5G2	0.46	0.46	lasso	7	0.46	7.5e-15	5.83	6.9	3.7e-12	0.60	0.99	0.01	FALSE
7	GTEx	Adrenal Gland	PRR13	0.18	0.02	lasso	10	0.04	1.3e-02	-0.83	6.9	4.3e-12	0.41	0.03	0.72	FALSE
81	The Cancer Genome Atlas	Lung Adenocarcinoma	AMHR2	0.06	0.00	enet	13	0.02	7.0e-04	7.26	6.9	7.4e-12	0.35	0.00	0.07	FALSE
21	GTEx	Brain Putamen basal ganglia	ATP5G2	0.26	0.26	lasso	6	0.21	1.0e-05	6.84	6.7	1.7e-11	0.55	0.26	0.20	FALSE
22	GTEx	Brain Putamen basal ganglia	RP11-793H13.3	0.29	-0.01	enet	49	0.02	1.0e-01	1.12	6.7	1.7e-11	0.40	0.05	0.11	FALSE
69	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ATP5G2	0.06	0.04	lasso	6	0.06	7.1e-06	-5.82	6.6	5.2e-11	0.41	0.37	0.29	FALSE
72	The Cancer Genome Atlas	Colon Adenocarcinoma	ATP5G2	0.07	0.06	lasso	2	0.06	4.0e-04	6.84	6.5	8.0e-11	0.53	0.37	0.11	FALSE
49	GTEx	Ovary	ATP5G2	0.41	0.29	lasso	12	0.28	1.7e-07	5.83	6.5	1.1e-10	0.53	0.65	0.08	FALSE
50	GTEx	Pituitary	ATP5G2	0.18	0.18	lasso	12	0.15	1.1e-04	4.48	6.4	1.3e-10	0.52	0.17	0.51	FALSE
34	GTEx	Esophagus Mucosa	ATP5G2	0.29	0.39	lasso	9	0.42	5.3e-30	5.81	6.4	1.7e-10	0.49	1.00	0.00	FALSE
57	GTEx	Testis	ATP5G2	0.22	0.29	lasso	3	0.29	2.1e-13	5.81	6.4	1.7e-10	0.57	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	ATP5G2	0.20	0.10	lasso	7	0.12	9.4e-07	5.81	6.3	2.2e-10	0.50	0.97	0.00	FALSE
46	GTEx	Nerve Tibial	ATP5G2	0.26	0.31	lasso	6	0.30	2.1e-21	5.81	6.3	3.6e-10	0.54	1.00	0.00	FALSE
41	GTEx	Liver	RP11-793H13.11	0.22	0.10	lasso	4	0.03	6.4e-02	5.83	-6.2	4.3e-10	-0.51	0.16	0.21	FALSE
56	GTEx	Stomach	ATP5G2	0.16	0.18	lasso	4	0.14	3.4e-07	5.83	6.2	7.2e-10	0.55	0.98	0.01	FALSE
73	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ATP5G2	0.09	0.11	lasso	2	0.10	1.5e-11	5.83	6.1	9.5e-10	0.52	1.00	0.00	FALSE
62	GTEx	Vagina	ATP5G2	0.38	0.37	lasso	7	0.36	4.2e-09	6.15	6.1	1.3e-09	0.52	0.65	0.04	FALSE
82	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ATP5G2	0.02	0.03	blup	67	0.02	4.5e-03	5.83	6.1	1.4e-09	0.52	0.17	0.22	FALSE
15	GTEx	Brain Cerebellar Hemisphere	ATP5G2	0.52	0.33	lasso	6	0.29	3.0e-08	5.81	6.0	2.5e-09	0.49	0.76	0.07	FALSE
16	GTEx	Brain Cerebellum	ATP5G2	0.38	0.50	lasso	5	0.50	6.4e-17	5.81	5.9	3.1e-09	0.52	1.00	0.00	FALSE
37	GTEx	Esophagus Muscularis	ATP5G2	0.23	0.34	lasso	6	0.32	2.9e-20	5.83	5.9	3.9e-09	0.52	1.00	0.00	FALSE
59	GTEx	Thyroid	ATP5G2	0.10	0.13	lasso	4	0.10	8.8e-08	5.81	5.8	5.2e-09	0.52	1.00	0.00	FALSE
42	GTEx	Lung	ATP5G2	0.18	0.20	lasso	2	0.20	7.6e-15	5.83	5.8	5.6e-09	0.52	1.00	0.00	FALSE
8	GTEx	Artery Aorta	ATP5G2	0.09	0.12	lasso	1	0.11	1.3e-06	5.81	5.8	6.2e-09	0.52	0.88	0.02	FALSE
29	GTEx	Colon Transverse	ATP5G2	0.16	0.19	lasso	4	0.18	9.3e-09	5.83	5.8	8.1e-09	0.52	0.98	0.01	FALSE
19	GTEx	Brain Frontal Cortex BA9	ATP5G2	0.24	0.20	lasso	5	0.13	3.2e-04	5.83	5.7	9.2e-09	0.50	0.18	0.18	FALSE
20	GTEx	Brain Hippocampus	ATP5G2	0.18	0.10	enet	21	0.05	2.3e-02	6.31	5.6	2.5e-08	0.35	0.09	0.06	FALSE